Dry sensitive skin repairing composition and application thereof

Abstract

The invention particularly relates to a dry sensitive skin repairing composition and application thereof. The composition is prepared from blue copper peptide, a plant soothing agent and 4-butyl cyclohexanol, the weight ratio of the copper-blue peptide to the plant soothing agent to the 4-butyl cyclohexanol is (0.1 to 0.6) to (1 to 6) to (0.2 to 1.2). The dry and sensitive skin repairing composition is provided for solving the problems that an existing sensitive skin repairing product is not high in pertinence, long in product effective period, not remarkable in effect and the like, a barrier is effectively repaired through scientific and reasonable compounding and a specific target spot, the skin inflammation reaction is effectively reduced, the skin sensory nerves are reasonably adjusted, and the skin repairing effect is good. The traditional Chinese medicine composition can improve the skin state of dry sensitive skin, is prepared into repairing essence, has a remarkable repairing effect on the dry sensitive skin, and achieves the effects of strongly repairing the dry sensitive skin within 3 days and completely improving the sensitive symptom within 7 days.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics, and particularly relates to a dry sensitive skin repairing composition and application thereof. Background Art

[0002] At present, the main causes involved in the research on sensitive skin include: impaired skin barrier function, inflammatory state of the epidermis, abnormal skin sensory nervous system, etc. Among them, excessive cleaning, use of irritating skin care products, environmental factors (such as ultraviolet rays, dry climate), etc. are likely to lead to impaired skin barrier function, which is mainly manifested in thinning of the skin stratum corneum, easy loss of skin moisture, and susceptibility to external environmental irritants; and long-term inflammation will destroy the normal structure of the skin, making the skin sensitive. After being stimulated, the skin is prone to inflammatory reactions, such as redness, swelling, itching, etc.; the skin sensory nerves are responsible for transmitting the sensory information of the skin. When these nerves are abnormal, they may amplify the skin's response to stimulation. These causes often promote and interfere with each other, causing sensitive skin problems to fall into a vicious cycle and are not easy to transform into normal skin.

[0003] Different types of skin have different skin conditions when they are sensitive. The Baumann Skin Type Indicator (BSTI) is a skin type classification system proposed by Leslie Baumann, a professor of dermatology at the University of Miami. According to different combinations of four binary parameters (i.e. oily or dry, stable or sensitive, pigmented or non-pigmented, loose or tight), 16 different skin types can be obtained. Each type has its own specific skin characteristics and care needs. Dry sensitive skin is a combination of "dry" and "sensitive" in the Baumann skin classification. This skin type is characterized by a lack of oil in the skin, poor moisturizing function, and is very sensitive to external stimuli.

[0004] There are many repair products on the market. For example, Chinese patent document CN115813812A discloses a dry sensitive skin repair composition and its application, and discloses that the dry sensitive skin repair composition includes C13-16 isoparaffin, European bilberry seed oil, golden jojoba oil, N-palmitoyl hydroxyproline cetyl ester, sunflower seed oil unsaponifiable matter and white meadowfoam seed oil and other ingredients. Its repair mechanism is not comprehensive. The subjects only have a repair effect after 14 days of use. The area of ​​the basal red zone is reduced by 15% to 40%, the transepidermal water loss rate is reduced by 21% to 60%, the skin water content is increased by 23% to 42%, and the pore area ratio is reduced by 5% to 27%. Chinese patent document CN116421513A discloses a skin care product composition with sensitive skin soothing and repairing effects and its preparation method, and discloses that the skin care product composition with sensitive skin repairing effects contains the following raw material components by mass percentage: 1-10 parts of carboxymethyl deacetylated chitosan, 1-5 parts of 1,2-hexanediol, 20-60 parts of water, 1-5 parts of hydroxyphenyl propionamide benzoic acid, 10-30 parts of 1,3-propylene glycol, 1-10 parts of phospholipids, 0.1-1 parts of tocopherol acetate, 10-30 parts of butylene glycol, and 0.1-1 parts of kava extract, but the formula needs to use high-purity phospholipids to encapsulate the active ingredients, and the particle size is about 45nm through the multi-liposome technology process. The selection of the preparation process and formula system is complicated, the product ingredients are generalized, the pertinence is not strong, the repair mechanism is not comprehensive, and the effect is not significant. It can be seen that the existing sensitive skin repair products have problems such as weak pertinence, long effective period, and insignificant effect. Summary of the invention

[0005] In view of the deficiencies in the prior art, the present invention aims to provide a dry sensitive skin repair composition and its application. In view of the problems that the existing sensitive skin repair products are not targeted, the product has a long effective period, and the effect is not significant, a repair product for dry sensitive skin with a short effective period and significant effect is provided, starting from three dimensions: peroxisome proliferator receptor (PPAR) agonists, which are key factors in repairing the skin barrier; interleukins and tumor necrosis factors, which are key cytokines for relieving skin inflammatory reactions; transient receptor potential vanilloid 1 (TRPV1), which regulates the sensitization of key receptors of skin sensory nerves, to regulate and maintain dry sensitive skin from multiple angles and with scientific basis, so as to solve the discomfort symptoms of dry sensitive skin from the root.

[0006] In order to achieve the above object, the present invention adopts the following technical solutions:

[0007] The first object of the present invention is to provide a dry sensitive skin repairing composition, the composition comprising blue copper peptide, plant soothing agent and 4-butyl cyclohexanol;

[0008] The weight ratio of the blue copper peptide, the plant soothing agent and 4-butyl cyclohexanol is (0.1-0.6): (1-6): (0.2-1.2).

[0009] Preferably, the preparation method of the plant soothing agent comprises:

[0010] (1) Preparation of birch bark extract: pulverize birch bark into powder of 30-50 mesh, use 60-85% ethanol solution as solvent, mix at a mass ratio of solvent to powder of (10-15):1, extract birch bark at 60-80°C using 300-400W microwave extraction for 20-30 minutes, repeat 2-3 times, and then distill and crystallize under reduced pressure to obtain a mixture of betulin and betulic acid, which is then dissolved in dipropylene glycol to obtain a birch bark extract solution with a concentration of 25-35%;

[0011] (2) Preparation of the extract of Scrophularia ningpoensis: using hot water at 50-70°C as a solvent, with a solid-liquid ratio of 1:(5-10), extracting at 500-700W, 30-50HZ ultrasonic cycle for 40-50 minutes, repeating 2-3 times, concentrating and separating to obtain an cycloterpene mixture, and then dissolving it in dipropylene glycol to obtain a Scrophularia ningpoensis extract solution with an cycloterpene concentration of 5-15%;

[0012] (3) Preparation of a plant soothing agent: The birch bark extract of step (1) and the Scrophularia ningpoensis extract of step (2) are mixed to prepare a plant soothing agent with a content of 3-6%.

[0013] The second object of the present invention is to provide a use of the above composition in preparing cosmetics for improving sensitive skin.

[0014] Another object of the present invention is to provide a repair essence for dry sensitive skin, the repair essence comprising the repair composition according to claim 1, cosmetically acceptable excipients and cosmetically acceptable solvents.

[0015] Preferably, in the repair essence, in terms of mass percentage, the repair composition is 2.2-11%, the auxiliary material is 6.5-35%, and the balance is the solvent.

[0016] Preferably, the auxiliary materials include moisturizers, thickeners, emulsifiers, emollients and pH regulators;

[0017] In the repair essence, the humectant is 5-15%, the thickener is 0.1-1%, the emulsifier is 0.5-2.0%, the emollient is 1-10%, and the pH regulator is 0.01-2%, calculated by mass percentage.

[0018] Preferably, the humectant includes one or more of glycerol, propylene glycol, butylene glycol, sorbitol, and 1,2-hexanediol;

[0019] The thickener includes one or more of polyacrylate crosspolymer-6, ammonium acryloyldimethyltaurate / VP copolymer, ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymer, and hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer;

[0020] The emulsifier includes one or more of hydrogenated lecithin, isohexadecane, polysorbate-60, sorbitan isostearate, polyacrylate-13, polyisobutylene, polysorbate-20, polyacrylamide, C13-14 isoparaffin, and laureth-7;

[0021] The emollient comprises one or more of avocado butter, coconut oil alcohol-caprylate / caprate, polydimethylsiloxane, triglyceride, and isononyl isononanoate;

[0022] The pH regulator includes one or more of lactic acid, arginine, citric acid, sodium hydroxide, potassium hydroxide, aminomethyl propanol, and tromethamine.

[0023] Preferably, in the repair essence, the components are, by mass percentage, 0.1-0.6% blue copper peptide, 1-6% plant soothing agent, 0.2-1.2% 4-butyl cyclohexanol, 2-8% glycerol, 3-8% 1,3-butanediol, 0.1-2% 1,2-hexanediol, 1-5% polyacrylate cross-linked polymer-6, 0.5-2% emulsifier, 0.01-0.5% citric acid, and the balance is solvent.

[0024] Another object of the present invention is to provide a cosmetic for improving sensitive skin, which is prepared from the above-mentioned repair essence.

[0025] Preferably, the sensitive skin is dry sensitive skin; and the cosmetics are used to prevent or relieve skin allergies.

[0026] Compared with the prior art, the present invention has the following beneficial effects:

[0027] The present invention provides a repairing composition for dry and sensitive skin. The composition is prepared by using a specific plant soothing agent, blue copper peptide and 4-butyl cyclohexanol as main ingredients, and through scientific and reasonable compounding and specific target strong repair barrier, the skin inflammatory response is effectively reduced, the skin sensory nerves are reasonably regulated, and the skin condition of dry and sensitive skin is improved. The composition is prepared into a repairing essence, which has a significant repairing effect on dry and sensitive skin, achieves the effect of strong repair for 3 days and the effect of completely improving sensitive symptoms for 7 days, and solves the problems of existing sensitive skin repair products having low pertinence, long product effect period, and insignificant effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 This is a VISIA CR facial photography result of a subject using the dry and sensitive skin repair essence prepared by adding the repair composition of Example 1 of the present invention;

[0029] Figure 2 The VISIA CR facial photography results of the test subject using the dry and sensitive skin repair essence prepared by adding the repair composition of Example 2 of the present invention;

[0030] Figure 3 The VISIA CR facial photography results of the test subject using the dry and sensitive skin repair essence prepared by adding the repair composition of Example 3 of the present invention;

[0031] Figure 4 The VISIA CR facial photography results of the test subject using the dry and sensitive skin repair essence prepared by adding the repair composition of Example 4 of the present invention;

[0032] Figure 5 The VISIA CR facial photography results of the test subject using the dry and sensitive skin repair essence prepared by adding the repair composition of Example 5 of the present invention;

[0033] Figure 6 The VISIA CR facial photography results of the subjects who were experimented with the dry and sensitive skin repair essence prepared by adding the repair composition of Comparative Example 1 of the present invention;

[0034] Figure 7 The VISIA CR facial photography results of the subjects who were experimented with the dry and sensitive skin repair essence prepared by adding the repair composition of Comparative Example 2 of the present invention;

[0035] Figure 8 The VISIA CR facial photography results of the test subjects using the dry and sensitive skin repair essence prepared by adding the repair composition of Comparative Example 3 of the present invention;

[0036] Fig. 9 The VISIA CR facial photography results of the subjects who were experimented with the dry and sensitive skin repair essence prepared by adding the repair composition of Comparative Example 4 of the present invention;

[0037] Fig.10 The VISIA CR facial photography results of the subjects who were experimented with the dry and sensitive skin repair essence prepared by adding the repair composition of Comparative Example 5 of the present invention;

[0038] Fig.11The VISIA CR facial photography results of a test subject using the dry and sensitive skin repair essence prepared by adding the repair composition of Comparative Example 6 of the present invention are shown. DETAILED DESCRIPTION

[0039] The above contents of the present invention are further described in detail below by means of specific implementation methods in the form of examples, but this should not be understood as the scope of the above subject matter of the present invention being limited to the following examples.

[0040] 1. Raw materials:

[0041] Table 1

[0042]

[0043]

[0044] 2. Design principle or inventive concept of the present invention:

[0045] The main raw materials of the dry sensitive skin repair composition provided by the present invention include blue copper peptide, plant soothing agent and 4-butyl cyclohexanol, wherein:

[0046] (1) Mechanism of action of blue copper peptide:

[0047] Blue copper peptide, also known as tripeptide-1 copper or GHK-Cu, is a small molecule human copper peptide conjugate naturally present in human plasma, urine, saliva, and cerebrospinal fluid. It is composed of a tripeptide and its high-affinity divalent copper ion. It was originally discovered by Pickart et al., separated from human plasma, and described as a growth factor for a variety of differentiated cells and a regulator of the extracellular matrix. As a polypeptide component, blue copper peptide has a variety of skin care and repair functions. For example, it has PPAR agonist properties and can promote keratinocyte proliferation, angiogenesis, fibroblast proliferation, and extracellular matrix expression. Therefore, in the dry sensitive skin repair composition of the present invention, blue copper peptide is used as a peroxisome proliferator receptor (PPAR) agonist, which mainly plays a role in repairing the skin barrier by regulating and promoting the differentiation of keratinocytes and promoting the synthesis of epidermal fat.

[0048] (2) Mechanism of action of plant soothing agents:

[0049] Phytosoothing is an active ingredient refined and refined by combining molecular modeling, traditional Chinese medicine and modern bioinformatics. It is composed of 4.75% SCROPH ULARIA NODOSA extract and 4.75% BETULAALBA bark extract dissolved in 90.5% dipropylene glycol. Existing studies have shown that dendritic cells that were previously exposed to UVB have significantly restored the expression of tumor necrosis factor TNF-α after being treated with phytosoothing. This finding strongly proves the protective and repairing effect of phytosoothing on damaged skin cells. Further in vitro testing, phytosoothing also showed excellent soothing and immunomodulatory functions at the macrophage level. It significantly inhibited the release of interleukin-1α by UV-irradiated cells, a cytokine that plays a key role in skin inflammatory responses. Therefore, phytosoothing has a significant effect in reducing skin inflammatory responses, relieving redness, swelling and discomfort. Based on the above research, the inventors of the present invention have specially added a plant soothing agent to the dry and sensitive skin repairing composition of the present invention, which can relieve skin discomfort by reducing the release of inflammatory factors, while promoting the repair and regeneration of damaged skin cells, bringing a comprehensive and effective care experience to people with dry and sensitive skin.

[0050] (3) Mechanism of action of 4-butyl cyclohexanol:

[0051] 4-Butylcyclohexanol is a sensory modulator that focuses on the cellular level. It shows a significant effect in regulating the sensory nerves of the skin. In normal skin, specific nerve receptors on the cell membrane are responsible for regulating the flow of calcium to ensure that it is in a stable state. However, in sensitive skin, more TRPV1 (transient receptor potential vanilloid subfamily member 1) nerve receptors are activated, resulting in uncontrolled calcium flux, which in turn causes symptoms such as skin irritation and inflammation. 4-Butylcyclohexanol can specifically regulate the activity of TRPV1 nerve receptors, and through its mechanism of action, it quickly restores calcium flow to normal levels, thereby effectively regulating the sensory nerves of the skin. This is of great significance for alleviating symptoms of sensitive skin, such as burning, stinging, and itching. TRPV1 receptors can be activated at physiological or subphysiological temperatures (lower than their normal activation temperature), and this temperature change may cause a series of uncomfortable symptoms in sensitive skin. When the TRPV1 receptor channel is activated, it opens a non-selective cation channel to allow Ca 2+ and Na +Enter the cell. The depolarization produced by this ion flow is sensed and amplified by the voltage-gated sodium channel, which then initiates the action potential, transduces the pain signal to the dorsal horn of the spinal cord, and finally transmits it to the brain. Therefore, in the dry sensitive skin repairing composition of the present invention, 4-butyl cyclohexanol mainly regulates the activity of TRPV1 nerve receptors, reduces the abnormal flow of calcium ions, thereby alleviating the symptoms of sensitive skin and effectively repairing dry sensitive skin. This mechanism of action makes 4-butyl cyclohexanol an ideal choice for repairing dry sensitive skin.

[0052] To sum up, firstly, the present invention screens blue copper peptide, plant soothing agent and 4-butyl cyclohexanol as a combination of ingredients with synergistic effects, wherein blue copper peptide, plant soothing agent and 4-butyl cyclohexanol are taken as core components, and the components of the composition of the present invention are combined according to different proportions of each component, and finally the content ratio composition with the best effect is determined. It can be seen that the present invention provides a dry and sensitive skin repairing composition suitable for people with dry and sensitive skin, which adopts blue copper peptide, plant soothing agent and 4-butyl cyclohexanol as main formula raw materials, starting from three dimensions: peroxisome proliferator-activated receptor (PPAR) agonist, a key factor in repairing skin barrier, interleukin and tumor necrosis factor, a key cytokine for alleviating skin inflammatory response, and transient receptor potential vanilloid subfamily member 1 (TRPV1), which regulates the sensitization of key receptors of skin sensory nerves, to carry out multi-angle, scientific and well-founded conditioning and maintenance for dry and sensitive skin, solve the discomfort symptoms of dry and sensitive skin from the root, achieve the effect of 3 days of strong repair and 7 days of complete improvement of sensitive symptoms, and have a significant repair effect on dry and sensitive skin.

[0053] Example 1 Preparation of plant soothing agent

[0054] The preparation process of the plant soothing agent specifically includes:

[0055] (1) Preparation of birch bark extract: pulverize birch bark into 40 mesh powder, use 7:3 ethanol and water as solvent, and mix them in a mass ratio of 12:1 between the solvent and the powder. Extract the birch bark at 70° C. using 350W microwave extraction for 25 minutes. Repeat this process three times, and then perform vacuum distillation and crystallization to obtain a mixture of betulin and betulic acid, which is then dissolved in dipropylene glycol to obtain a 30% birch bark extract solution.

[0056] (2) Preparation of Scrophularia ningpoensis extract: Using 60°C hot water as solvent, the solid-liquid ratio is 1:8, and ultrasonic cyclic extraction is performed at 600W, 40HZ for 45 minutes. After repeating twice, the mixture is concentrated and separated to obtain an iridoid mixture, which is then dissolved in dipropylene glycol to obtain a Scrophularia ningpoensis extract solution with an iridoid concentration of 10%;

[0057] (3) Preparation of plant soothing agent: The birch bark extract of step (1) and the Scrophularia ningpoensis extract of step (2) are mixed to prepare a plant soothing agent with a content of 4.75% for both.

[0058] Example 2 Preparation of plant soothing agent

[0059] The preparation process of the plant soothing agent specifically includes:

[0060] (1) Preparation of birch bark extract: pulverize birch bark into 50 mesh powder, use 7:3 ethanol and water as solvent, and mix them in a mass ratio of 10:1 between the solvent and the powder. Extract the birch bark at 70° C. using a 400 W microwave extraction method for 25 minutes. Repeat this for 3 times, and then perform vacuum distillation and crystallization to obtain a mixture of betulin and betulic acid, which is then dissolved in dipropylene glycol to obtain a 30% birch bark extract solution.

[0061] (2) Preparation of Scrophularia ningpoensis extract: Using 60°C hot water as solvent, the solid-liquid ratio is 1:5, and ultrasonic cyclic extraction is performed at 600W, 40HZ for 45 minutes. After repeating twice, the mixture is concentrated and separated to obtain an iridoid mixture, which is then dissolved in dipropylene glycol to obtain a Scrophularia ningpoensis extract solution with an iridoid concentration of 10%;

[0062] (3) Preparation of plant soothing agent: The birch bark extract of step (1) and the Scrophularia ningpoensis extract of step (2) are mixed to prepare a plant soothing agent with a content of 4.75% for both.

[0063] Example 3 Preparation of plant soothing agent

[0064] The preparation process of the plant soothing agent specifically includes:

[0065] (1) Preparation of birch bark extract: pulverize birch bark into 30 mesh powder, use 7:3 ethanol and water as solvent, and mix them in a mass ratio of 15:1 between the solvent and the powder. Extract the birch bark at 70° C. using a 300 W microwave extraction method for 25 minutes. Repeat this for 3 times, and then perform vacuum distillation and crystallization to obtain a mixture of betulin and betulic acid, which is then dissolved in dipropylene glycol to obtain a 30% birch bark extract solution.

[0066] (2) Preparation of Scrophularia ningpoensis extract: Using 60°C hot water as solvent, the solid-liquid ratio is 1:10, and ultrasonic cyclic extraction is performed at 600W, 40HZ for 45 minutes. After repeating twice, the cyclopentane mixture is concentrated and separated to obtain the cyclopentane mixture, which is then dissolved in dipropylene glycol to obtain a Scrophularia ningpoensis extract solution with an cyclopentane concentration of 10%;

[0067] (3) Preparation of plant soothing agent: The birch bark extract of step (1) and the Scrophularia ningpoensis extract of step (2) are mixed to prepare a plant soothing agent with a content of 4.75% for both.

[0068] Preparation of dry sensitive skin repairing compositions of Examples 4 to 5 and Comparative Examples 1 to 6

[0069] The plant soothing agent prepared in Example 1 is used to prepare the dry sensitive skin repairing composition. The formula composition is shown in the following table by weight ratio:

[0070] Table 2

[0071]

[0072] Application Example 1 Preparation of Essence Containing Dry Sensitive Skin Repairing Composition

[0073] The essence containing the dry sensitive skin repairing composition comprises the following raw materials in terms of mass percentage:

[0074] Table 3

[0075]

[0076] The method for preparing the above-mentioned essence containing the dry sensitive skin repairing composition comprises the following steps:

[0077] (1) Mix the humectant, thickener and water under stirring until they are uniform, and stir at 85° C. for 1 h to prepare phase A;

[0078] (2) adding the emollient and the emulsifier in sequence and mixing them until they are uniform, and then stirring them at 85° C. for 1 h to obtain phase B;

[0079] (3) Add phase A to phase B and homogenize at medium speed to obtain phase C base material;

[0080] (4) When the temperature is lowered to 45° C. while stirring, add the repair composition of Examples 4 to 8 or Comparative Examples 1 to 6 to the phase C base material and stir evenly to obtain phase D;

[0081] (5) After the phase D is stirred evenly and cooled to 35-40° C., flavor is added, and the pH is adjusted to 5.5-6.5 with a pH adjuster to obtain the dry sensitive skin repair essence.

[0082] Experiment 1 Patch Test

[0083] 1. Test substance: The dry and sensitive skin repair essence prepared in Example 1 and added with the repair compositions of Examples 4 to 8 were placed in blank filter papers respectively.

[0084] 2. Blank control: blank filter paper control

[0085] 3. Subjects: A total of 175 subjects, including 45 males and 130 females; aged 23 to 37 years old, with an average age of 28 years old, met the voluntary selection criteria for subjects, with specific reference to the human skin patch test in the "Technical Specifications for Safety of Cosmetics" (2015).

[0086] 4. Patch test method: Use the closed patch test method to place about 0.020-0.025 mL of the test substance in the chamber of the patch tester (purchased from Beijing Baiyi Yida Technology Development Co., Ltd., model skin allergy tester), and the control well is a blank control (blank filter paper). The patch tester with the test substance is applied to the curved side of the subject's forearm with a low-allergenic tape, and the palm is gently pressed to evenly apply it to the skin. After 24 hours, the patch tester is removed. Observe the skin reaction 0.5 hour after the removal of the patch tester (after the indentation disappears), 24 hours, and 48 hours, and record the results according to the skin reaction grading standards in the current effective technical specifications.

[0087] 5. Skin reaction classification standards (refer to "Cosmetic Safety Technical Specifications" (2015)):

[0088] Table 4 Skin occlusive patch test skin reaction grading standard

[0089]

[0090] 6. Patch test results

[0091] Table 5

[0092]

[0093] Explanation of experimental results: It can be seen from the data in the above table that the test results of the skin patch test of the dry and sensitive skin repair essence added with the repair composition of Examples 4 to 8 are all negative reactions, indicating that the repair essence prepared in Examples 4 to 8 of the present invention has no potential adverse reactions to human skin, is highly safe, mild, and suitable for people with sensitive skin.

[0094] Experiment 2: Human testing

[0095] 180 people with dry skin and obvious sensitive symptoms (average water content: 30-40, lactic acid stimulation: ≥4) were recruited and randomly divided into groups of 15 people each. Each group of volunteers used blank moisturizing water + (with the repair composition of Examples 4 to 8 or Comparative Examples 1 to 6) dry and sensitive skin repair essence, which was used every morning and evening for 7 days. The moisture content of the stratum corneum of the volunteers' skin, the transepidermal water loss TEWL value of the skin, the hemoglobin content (EI) of the skin, the a value of the skin, Visia-7 shooting image analysis, lactic acid stinging test, and self-assessment of the subjects were measured at the 3rd and 7th day time points to evaluate the repair, moisturizing, and soothing effects of the test samples, various sensory indicators and product safety. The improvement trend is compared by the rate of change, which is obtained by subtracting the initial value before the product is used from the value measured after the product is used. Among them, each test item randomly selects one side of the face for measurement 3 times.

[0096] (1) Testing of skin stratum corneum moisture content, skin transepidermal water loss TEWL value, skin hemoglobin content (EI), skin a value and lactic acid sting test, including the following steps:

[0097] 1) After washing the face, the subjects rested for 15 to 20 minutes in a constant temperature and humidity chamber (ambient temperature was (21±1)°C, relative humidity was (45±5%)), and facial images were collected using a facial high-definition imager VISIA-7. Then, one cheek was randomly selected to measure the subjects' initial transepidermal water loss TEWL value, skin stratum corneum moisture content, a value (skin redness), EI value (skin hemoglobin content), and lactic acid stimulation score.

[0098] 2) Distribute test samples and inform the subjects of how to use the products. The subjects should take the samples home and use them once a day in the morning for 2 consecutive weeks.

[0099] 3) Regularly conduct return visits and fill in questionnaires; after using the product for a certain period of time, measure the moisture content of the skin stratum corneum, the transepidermal water loss TEWL value, the EI value (skin hemoglobin content), the skin a value (skin redness) and conduct a lactic acid sting test. The experimental results are shown in Tables 6 to 10 below.

[0100] Table 6 Water content of skin stratum corneum

[0101] Group / Moisture content (%) Day 0 3 days 7 days Rate of change (7 days) Example 4 35.47 40.95 48.12 35.66％ Example 5 35.33 37.11 40.11 13.53％ Example 6 32.55 35.24 39.19 20.40％ Example 7 38.71 40.98 45.73 18.13％ Example 8 36.45 39.36 40.74 11.77％ Comparative Example 1 38.14 35.36 40.28 5.61％ Comparative Example 2 36 39.34 41.77 16.03％ Comparative Example 3 33.65 36.63 39.14 16.32％ Comparative Example 4 34.32 36.96 37.87 10.34％ Comparative Example 5 36 39.64 40.32 12.00％ Comparative Example 6 37.39 39.33 42.55 13.80％ Blank moisturizing water group 36.01 36.10 35.38 1.75％

[0102] Among them, the increased moisture content of the skin's stratum corneum indicates that the skin's moisture content is higher and the repair effect is better, that is, the higher the rate of change.

[0103] Table 7 Transepidermal Water Loss TEWL Values

[0104]

[0105]

[0106] Among them, a lower TEWL value indicates less transepidermal water loss per unit time and unit cross-sectional area, that is, better skin repair and a greater negative value of the rate of change.

[0107] Table 8 Skin hemoglobin content (EI)

[0108] Group / EI Day 0 3 days 7 days Rate of change (7 days) Example 1 313.33 255.25 248.81 -20.59％ Example 2 298.87 278.35 250.38 -16.22％ Example 3 303.15 289.12 258.33 -14.78％ Example 4 284.21 269.45 254.11 -10.59％ Example 5 294.46 276.54 259.78 -11.78％ Comparative Example 1 274.54 267.44 245.56 -10.56％ Comparative Example 2 281.77 269.55 257.54 -8.60％ Comparative Example 3 291.49 277.55 267.44 -8.25％ Comparative Example 4 283.61 268.44 260.15 -8.27％ Comparative Example 5 300.14 280.77 265.45 -11.56％ Comparative Example 6 275.94 261 248.09 -10.09％ Blank moisturizing water group 298.63 297.81 297.37 -0.42％

[0109] Among them, the lower the EI value, the lower the skin hemoglobin content, that is, the better the skin repair, and the greater the negative value of the change rate.

[0110] Table 9 Skin a value

[0111]

[0112]

[0113] Among them, the lower the a value, the better the skin redness is improved, and the greater the negative value of the change rate.

[0114] Table 10 Lactic acid sting test results

[0115]

[0116] Among them, the lower the test value of lactic acid stinging, the better the skin condition, that is, the better the skin repair effect, and the greater the negative value of the change rate.

[0117] (2) Analysis of images captured by Visia-7

[0118] The dry and sensitive skin repair essence prepared by adding the repair compositions of Examples 4 to 8 of the present invention and Comparative Examples 1 to 6 was used for an experiment. After using the test sample for one week, the facial high-definition imager (purchased from the United States) was used to The image of the left and right sides of the face was collected by the company manufacturer, model VISIA-7).

[0119] The analysis results of the images taken by Visia-7 are as follows Figures 1 to 11 As shown, the subjects used the dry and sensitive skin repair essence of the present invention, and on the 3rd and 7th days, the skin repair effect was relatively obvious, indicating that the dry and sensitive skin repair essence prepared by the present invention has a good repair effect.

[0120] (3) Volunteer Questionnaire Survey

[0121] A questionnaire survey was conducted on each group of volunteers in the above experiment to collect feedback on moisturizing effect, improvement of burning sensation, and improvement of redness. A very obvious effect was scored 5 points, a relatively obvious effect was scored 4 points, an average effect was scored 3 points, a slight improvement was scored 2 points, and no improvement was scored 1 point. The average score for each item was calculated and the results are shown in the table.

[0122] Table 11 Volunteer Questionnaire Survey Results

[0123] Experimental Group Moisturizing effect Improved burning sensation Redness Improvement Overall Rating Example 1 4.78 4.81 4.74 4.9 Example 2 3.89 4.12 4.05 4.45 Example 3 4.68 4.03 4.46 4.00 Example 4 3.99 4.65 4.06 4.05 Example 5 4.16 4.05 4.65 4.7 Comparative Example 1 1.96 1.33 1.42 1.92 Comparative Example 2 3.13 2.67 2.35 2.86 Comparative Example 3 2.94 2.25 2.0 2.35 Comparative Example 4 3.21 2.79 2.4 2.56 Comparative Example 5 2.06 1.43 1.30 1.76 Comparative Example 6 3.03 2.43 2.26 2.46 Comparative Example 7 2.99 2.10 2.03 1.98 Comparative Example 8 2.67 1.99 1.67 1.62 Blank moisturizing water group 1.20 0.22 0.34 0.82

[0124] It can be seen from the above experiment that compared with Example 4, Comparative Examples 1 to 6 respectively adjust the mass ratio of blue copper peptide, plant soothing agent and 4-butyl cyclohexanol, and the effects of Comparative Examples 1 to 6 are all worse than those of the embodiments of the present invention. It can be seen that the three main components of the dry sensitive skin repair composition of the present invention are complementary and indispensable. The present invention measures the moisture content of the stratum corneum of volunteers' skin, the transepidermal water loss TEWL value of the skin, the hemoglobin content (EI) of the skin, the a value of the skin, the image analysis of Visia-7, the lactic acid stinging test, and the self-assessment of the subjects. It can be seen that among them, Example 4 of the present invention shows the best 7-day change rate, showing a significant effect of repairing from three dimensions of barrier repair, inflammation improvement, and regulation of sensory nerve conduction in a short time.

[0125] In summary, the dry and sensitive skin repairing composition provided by the present invention is prepared into a repair essence through scientific and reasonable compounding, which can effectively repair the barrier through specific targets, effectively reduce skin inflammatory response, reasonably regulate skin sensory nerves, and improve the skin condition of dry and sensitive skin. It has a significant repairing effect on dry and sensitive skin, achieving the effect of 3 days of strong repair and 7 days of complete improvement of sensitive symptoms.

[0126] The above embodiments are merely illustrative of the principles and effects of the present invention, and are not intended to limit the present invention. Anyone familiar with the art may modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by a person of ordinary skill in the art without departing from the spirit and technical concept disclosed by the present invention shall still be covered by the claims of the present invention.

Claims

1. A composition for repairing dry and sensitive skin, characterized in that: The composition includes blue copper peptide, plant soothing agent and 4-butyl cyclohexanol; The weight ratio of the blue copper peptide, the plant soothing agent and 4-butyl cyclohexanol is (0.1-0.6): (1-6): (0.2-1.2).

2. The composition for repairing dry sensitive skin according to claim 1, characterized in that: The preparation method of the plant soothing agent comprises: (1) Preparation of birch bark extract: pulverize birch bark into powder of 30-50 mesh, use 60-85% ethanol solution as solvent, mix at a mass ratio of solvent to powder of (10-15):1, extract birch bark at 60-80°C using 300-400W microwave extraction for 20-30 minutes, repeat 2-3 times, and then distill and crystallize under reduced pressure to obtain a mixture of betulin and betulic acid, which is then dissolved in dipropylene glycol to obtain a birch bark extract solution with a concentration of 25-35%; (2) Preparation of the extract of Scrophularia ningpoensis: using hot water at 50-70°C as a solvent, with a solid-liquid ratio of 1:(5-10), extracting at 500-700W, 30-50HZ ultrasonic cycle for 40-50 minutes, repeating 2-3 times, concentrating and separating to obtain an cycloterpene mixture, and then dissolving it in dipropylene glycol to obtain a Scrophularia ningpoensis extract solution with an cycloterpene concentration of 5-15%; (3) Preparation of a plant soothing agent: The birch bark extract of step (1) and the Scrophularia ningpoensis extract of step (2) are mixed to prepare a plant soothing agent with a content of 3-6%.

3. Use of the composition as claimed in claim 1 in preparing cosmetics for improving sensitive skin.

4. A dry and sensitive skin repair essence, characterized in that: The repair essence comprises the repair composition according to claim 1, cosmetically acceptable auxiliary materials and cosmetically acceptable solvents.

5. The repair essence according to claim 4, characterized in that: In the repair essence, the repair composition accounts for 2.2-11% by weight, the auxiliary material accounts for 6.5-35% by weight, and the balance is the solvent.

6. The repair essence according to claim 5, characterized in that: The auxiliary materials include moisturizers, thickeners, emulsifiers, emollients and pH regulators; In the repair essence, the humectant is 5-15%, the thickener is 0.1-1%, the emulsifier is 0.5-2.0%, the emollient is 1-10%, and the pH regulator is 0.01-2%, calculated by mass percentage.

7. The repair essence according to claim 5, characterized in that The humectant includes one or more of glycerol, propylene glycol, butylene glycol, sorbitol, and 1,2-hexanediol; The thickener includes one or more of polyacrylate crosspolymer-6, ammonium acryloyldimethyltaurate / VP copolymer, ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymer, and hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer; The emulsifier includes one or more of hydrogenated lecithin, isohexadecane, polysorbate-60, sorbitan isostearate, polyacrylate-13, polyisobutylene, polysorbate-20, polyacrylamide, C13-14 isoparaffin, and laureth-7; The emollient comprises one or more of avocado butter, coconut oil alcohol-caprylate / caprate, polydimethylsiloxane, triglyceride, and isononyl isononanoate; The pH regulator includes one or more of lactic acid, arginine, citric acid, sodium hydroxide, potassium hydroxide, aminomethyl propanol, and tromethamine.

8. The repair essence according to claim 5, characterized in that The repair essence contains, by mass percentage, the following components: 0.1-0.6% blue copper peptide, 1-6% plant soothing agent, 0.2-1.2% 4-butyl cyclohexanol, 2-8% glycerol, 3-8% 1,3-butylene glycol, 0.1-2% 1,2-hexanediol, 1-5% polyacrylate cross-linked polymer-6, 0.5-2% emulsifier, 0.01-0.5% citric acid, and the balance is solvent.

9. A cosmetic for improving sensitive skin, which is prepared from the repair essence according to claim 4.

10. The cosmetic according to claim 9, characterized in that: The sensitive skin is dry sensitive skin; the cosmetics are used to prevent or alleviate skin allergies.

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