Reaction kettle for chemical synthesis of bulk drugs

Abstract

The invention discloses a reaction kettle for chemical synthesis of bulk drugs, and belongs to the technical field of reaction kettles.The reaction kettle comprises a kettle body, a partition cylinder, a first driving assembly, a first stirring assembly and a second stirring assembly, the lower end of the partition cylinder is connected with the inner bottom wall of the kettle body through a supporting rod, and an annular channel is formed between the lower end of the partition cylinder and the inner bottom wall of the kettle body; the first stirring assembly comprises a first stirring paddle, and the first stirring paddle is located in the separation barrel and drives liquid in the separation barrel to move upwards. The separation barrel is arranged in the kettle body, the first stirring assembly drives liquid to move upwards, liquid materials in the kettle body are subjected to three-dimensional circulation, and precipitation is avoided; the material liquid has axial flow, radial flow and turbulent flow, so that the material mixing effect is good; the blocking assembly is arranged, the space inside the partition cylinder and the space outside the partition cylinder can be separated, precipitation of the materials is reduced through separated pre-stirring mixing and final overall stirring mixing, the materials fully react, and the quality of finished raw material medicine is improved.

Description

Technical Field

[0001] The invention belongs to the technical field of reactors, and in particular relates to a reactor used for chemical synthesis of raw materials. Background Art

[0002] The reactor realizes the heating, evaporation, cooling and low-speed mixing functions required by the process through the structural design and parameter configuration of the container. The API reactor is widely used in synthetic reactions. The materials are generally carbon manganese steel, stainless steel, zirconium, nickel-based (Hastelloy, Monel, Inconel) alloys and other composite materials.

[0003] Existing reactors need to be stirred to accelerate mixing during mixing reactions, but the existing stirring is just a simple rotation stirring, which not only causes the liquid to rotate regularly along with the rotation during stirring, but also the internal materials cannot be stirred disorderly, reducing the stirring efficiency. At the same time, during the rotation stirring, the materials will gradually settle from the center, resulting in incomplete reaction. Summary of the invention

[0004] In view of the above problems existing in the prior art, the technical problem to be solved by the present invention is to provide a reaction kettle for chemical synthesis of raw materials to avoid material precipitation and improve the mixing effect.

[0005] Technical solution: In order to solve the above technical problems, the technical solution adopted by the present invention is as follows:

[0006] A reaction kettle for chemical synthesis of raw materials, comprising a kettle body, a partition cylinder arranged in the kettle body, a first drive assembly arranged on the kettle body, a first stirring assembly connected to the first drive assembly, and a second stirring assembly connected to the first drive assembly, the lower end of the partition cylinder is connected to the bottom wall of the kettle body through a support rod, an annular channel is formed between the lower end of the partition cylinder and the bottom wall of the kettle body, the first stirring assembly comprises a first stirring paddle, the first stirring paddle is located in the partition cylinder, and the first stirring paddle drives the liquid in the partition cylinder upward.

[0007] Preferably, the second stirring assembly is connected to the first driving assembly through a transmission assembly, the first driving assembly includes a first driving motor, a driving shaft connected to the first driving motor, and a driving gear arranged on the driving shaft, and the transmission assembly includes a first gear corresponding to the driving gear and a second gear coaxially connected to the first driven gear.

[0008] Preferably, the second stirring assembly includes a mounting plate, a first annular gear ring arranged on the mounting plate and corresponding to the second gear, a second stirring rod connected to the mounting plate, and a second stirring paddle arranged on the second stirring rod, an annular slide rail is provided on the top wall of the kettle body, a sliding block corresponding to the annular slide rail is provided on the mounting plate, and the mounting plate is rotatably connected to the kettle body via the annular slide rail.

[0009] Preferably, the second stirring rod is rotatably connected to the mounting plate, a third gear is provided at the top end of the second stirring rod, and a third gear and a second annular gear ring corresponding to the third gear are provided on the top wall of the kettle body.

[0010] Preferably, a sealing assembly for sealing the annular channel is provided on the bottom wall of the kettle body, the sealing assembly includes a second driving assembly and a sealing ring connected to the second driving assembly, the bottom wall of the kettle body includes a first wall body located outside the sealing ring and a second wall body located inside the sealing ring, the second wall body is connected to the sealing ring, and the second driving assembly drives the sealing ring to move upward to seal the annular channel.

[0011] Preferably, the second driving assembly includes a second base, a second driving motor disposed on the second base, a second lead screw connected to the second drive motor, and a second slider movably connected to the second lead screw, and the second slider is connected to the sealing ring.

[0012] Preferably, the first stirring assembly further comprises a first stirring rod connected to the driving shaft, the first stirring paddle is arranged on the first stirring rod, and the mounting plate is provided with a through hole for the first stirring rod to penetrate.

[0013] Preferably, a first feed pipe and a second feed pipe are provided on the kettle body, a discharge pipe is provided on the bottom wall of the kettle body, the discharge port at the lower end of the second feed pipe is located above the partition cylinder, the material entering through the second feed pipe directly falls into the partition cylinder, and the discharge pipe is located below the partition cylinder.

[0014] Preferably, an annular slope with high sides and low center is provided on the inner bottom wall of the kettle body, and the height of the annular slope gradually decreases from the inner wall of the kettle body toward the annular channel.

[0015] Beneficial effects: Compared with the prior art, the present invention has the following advantages:

[0016] 1. A partition is arranged in the kettle body to form an annular channel between the partition and the bottom wall of the kettle body, and a first stirring assembly and a second stirring assembly are arranged to stir the inside and outside of the partition respectively. The first stirring assembly drives the liquid upward, and the liquid material in the kettle body is circulated three-dimensionally to avoid precipitation;

[0017] 2. The same driving component drives the first stirring component and the second stirring component to work, which reduces costs. The first stirring paddle drives the liquid to flow axially, the second stirring rod revolves to drive the liquid to flow radially, and the second stirring rod rotates to drive the second stirring paddle to rotate to form turbulence. The material liquid has both axial flow and radial flow and turbulence, and the material mixing effect is good;

[0018] 3. A sealing component is provided to separate the space inside and outside the partition tube, so that stirring and mixing can be performed separately. By coordinating the position settings of the two feed pipes, multiple materials of the raw materials can be pre-stirred and mixed separately inside and outside the partition tube. After preliminary mixing, the sealing ring is moved down to connect the inside and outside of the partition tube for further mixing. Through separate pre-stirring and mixing and final overall stirring and mixing, the precipitation of materials can be reduced, the materials can be fully reacted, and the quality of the finished raw materials can be improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the structure of a reactor according to an embodiment of the present invention;

[0020] Figure 2 2. It is a schematic diagram of the structure of the separator cylinder in the embodiment;

[0021] Figure 3 is a schematic structural diagram of a first driving assembly and a first stirring assembly in an embodiment;

[0022] Figure 4 It is a schematic diagram of the upper structure of the kettle;

[0023] Figure 5 is a schematic diagram of the three-dimensional structure of the first stirring component and the second stirring component;

[0024] Figure 6 It is a schematic diagram of the structure at the plugging component;

[0025] Figure 7 is a schematic diagram of the structure of the second drive assembly;

[0026] Figure 8 It is a structural schematic diagram of the blocking component when it is working. DETAILED DESCRIPTION

[0027] The present invention is further illustrated below in conjunction with specific examples. The examples are implemented based on the technical solutions of the present invention. It should be understood that these examples are only used to illustrate the present invention and are not used to limit the scope of the present invention.

[0028] like Figure 1 , Figure 2 , Figure 3 and Figure 4As shown, a reactor for chemical synthesis of raw materials includes a reactor body 1, a partition 2, a first drive component 3, a first stirring component 4, a second stirring component 5 and a transmission component 6. The reactor body 1 is generally in a hollow cylindrical shape. The partition 2 is arranged in the reactor body 1 and is coaxial with the reactor body 1. The partition 2 is a cylinder with upper and lower openings. A plurality of support rods 21 are connected to the lower end of the partition 2. The plurality of support rods 21 are distributed in an array at the lower end of the partition 2. The partition 2 is connected to the inner bottom wall of the reactor body 1 through the support rods 21. An annular channel is formed between the lower end of the partition 2 and the inner bottom wall of the reactor body 1. The material in the reactor body 1 enters the partition 2 through the annular channel. The upper end of the partition 2 is at a certain distance from the inner top wall of the reactor body 1. When the material is higher than the upper end of the partition 2, the material returns from the partition 2 to the reactor body 1. The first drive assembly 3 is arranged on the kettle body 1, and the first drive assembly 3 includes a first drive motor 31, a drive shaft 32 and a drive gear 33. The first drive motor 31 is arranged at the center position on the outer top wall of the kettle body 1. The first drive motor 31 adopts an existing AC motor and reducer combination. The drive shaft 32 is connected to the first drive motor 31 and passes through the top wall of the kettle body 1. The drive gear 33 is arranged on the drive shaft 32. The first stirring assembly 4 is connected to the first driving assembly 3. The first stirring assembly 4 includes a first stirring paddle 41 and a first stirring rod 42. The upper end of the first stirring rod 42 is connected to the driving shaft 32. The first stirring rod 42 extends downward into the partition 2. The first stirring paddle 41 is arranged at the lower end of the first stirring rod 42 and is located in the partition 2. When the first driving motor 31 is working, the first stirring paddle 41 is driven to rotate by the first stirring rod 42. The first stirring paddle 41 adopts the existing axial flow stirring paddle, which drives the liquid to move axially. In this embodiment, when the first stirring paddle 41 is working, it drives the liquid in the partition 2 to move upward. The liquid moving upward exceeds the upper end of the partition 2 and returns to the kettle body 1. The liquid in the kettle body 1 enters the lower end of the partition 2 through the annular channel and continues to be driven upward by the first stirring paddle 41, thereby completing the cycle. An annular slope 16 with high sides and low middle is provided on the inner bottom wall of the kettle body 1. The height of the annular slope 16 gradually decreases from the inner side wall of the kettle body 1 to the annular channel. The annular slope 16 can guide the liquid in the kettle body 1 to pass through the annular channel.

[0029] like Figure 1 , Figure 2 , Figure 3 , Figure 4 and Figure 5As shown, the second stirring assembly 5 is connected to the first driving assembly 3 through the transmission assembly 6. The transmission assembly 6 includes a first gear 61 and a second gear 62. The second gear 62 is arranged on the side of the driving gear 33 and meshes with the driving gear 33. An intermediate shaft is fixedly connected in the middle of the second gear 62. The top end of the intermediate shaft is rotatably connected to the top wall of the kettle body 1, and the lower end of the intermediate shaft is connected to the second gear 62, so that the second gear 62 is coaxially connected to the first driven gear 61. When the driving gear 33 drives the first gear 61 to rotate, the first gear 61 drives the second gear 62 to rotate synchronously through the intermediate shaft. The second stirring assembly 5 includes a mounting plate 51, a first annular gear ring 52, a second stirring rod 53 and a second stirring paddle 54. The mounting plate 51 is a circular plate and is arranged coaxially with the inner side of the kettle body 1. An annular slide rail 14 is arranged on the inner top wall of the kettle body 1. The cross section of the annular slide rail 14 is T-shaped. A plurality of sliders 55 corresponding to the annular slide rail 14 are arranged on the mounting plate 51. The sliders 55 are provided with T-shaped grooves corresponding to the annular slide rail 14, so that the sliders 55 can slide along the annular slide rail 14. The plurality of sliders 55 are distributed in an annular array on the upper end surface of the mounting plate 51. The mounting plate 51 is rotatably connected to the inner top wall of the kettle body 1 through the plurality of sliders 55. A circular through hole 511 is provided in the middle of the mounting plate 51, and the first stirring rod 42 passes through the through hole 511 from below and is connected to the driving shaft 32. The first annular gear ring 52 is provided on the upper end surface of the mounting plate 51, and a circle of teeth is provided on the inner side of the first annular gear ring 52. The position of the first annular gear ring 52 corresponds to the second gear 62, and the inner teeth of the first annular gear ring 52 are meshed with the second gear 62. When the second gear 62 rotates, the second gear 62 drives the mounting plate 51 to rotate through the first annular gear ring 52. A plurality of second stirring rods 53 are connected to the outer circumferential side of the mounting plate 51, and the plurality of second stirring rods 53 are distributed in a circular array, and the second stirring rods 53 extend downward between the outer wall of the partition cylinder 2 and the inner wall of the kettle body 1, and a plurality of second stirring paddles 54 are arranged on the outer circumferential wall of the second stirring rod 53, and four of the plurality of second stirring paddles 54 are symmetrically arranged in a group, and a plurality of groups of second stirring paddles 54 are equidistantly arranged on the second stirring rod 53, and when the mounting plate 51 rotates, the second stirring rod 53 is driven to rotate around the rotating partition cylinder 2, and the rotating second stirring rod 53 and the second stirring paddle 54 drive the liquid in the kettle body 1 to rotate.The top of the second stirring rod 53 passes through the mounting plate 51, and a bearing corresponding to the second stirring rod 53 is provided on the mounting plate 51. The second stirring rod 53 is rotatably connected to the mounting plate 51 through the bearing. A third gear 531 is provided at the top of the second stirring rod 53. A second annular gear ring 15 is provided on the inner top wall of the kettle body 1. A circle of teeth is provided on the outer circumferential side of the second annular gear ring 15. One circle of teeth of the second annular gear ring 15 meshes with the third gear 531. When the mounting plate 51 rotates, it drives the second stirring rod 53 to rotate around the partition tube 2. At the same time, the third gear 531 rotates around the second annular gear ring 15. When the third gear 531 rotates around the second annular gear ring 15, due to the action of a circle of teeth on the outer side of the second annular gear ring 15, the third gear 531 also rotates by itself, thereby driving the second stirring rod 53 to rotate by itself. When the second stirring rod 53 rotates by itself, it also drives the second stirring paddle 54 to rotate around the second stirring rod 53. The second stirring paddle 54 further stirs the liquid in the kettle body 1.

[0030] like Figure 1 , Figure 6 , Figure 7 and Figure 8As shown, a plugging component 7 is provided on the bottom wall of the kettle body 1, and the plugging component 7 is used to plug the annular channel. The plugging component 7 includes a second driving component 71 and a plugging ring 72. The two second driving components 71 are symmetrically arranged on the outer bottom wall of the kettle body 1. The plugging ring 72 is an annular plate. The inner ring diameter of the plugging ring 72 is equal to the inner ring diameter of the partition 2. The outer wall of the lower end of the plugging ring 72 is connected to the two second driving components 71 and moves up and down under the drive of the second driving component 71. The bottom wall of the kettle body 1 includes a first wall body 101 and a second wall body 102. The first wall body 101 is located outside the plugging ring 72 and is annular. The first wall body 101 is fixedly connected to the side wall of the kettle body 1, and the second wall body 102 is located inside the plugging ring 72 and is circular. The inner side of the upper end of the blocking ring 72 is connected, and when the blocking ring 72 moves upward, it drives the second wall 102 to move upward. After the blocking ring 72 moves upward driven by the second driving assembly 71, the blocking ring 72 is located on the inner side of the multiple support rods 21, and the top of the blocking ring 72 contacts the lower end of the partition tube 2, so that the blocking ring 72 blocks the annular channel, and the second wall 102 is located at the bottom of the partition tube 2 as the bottom wall of the partition tube 2. At this time, since the annular channel is closed, the liquid in the kettle body 1 cannot enter the partition tube 2 through the annular channel, and the liquid in the partition tube 2 and the liquid in the kettle body 1 can be stirred separately. The liquid in the partition tube 2 is stirred by the first stirring rod 42 and the first stirring paddle 41, and the liquid in the kettle body 1 is stirred by the second stirring paddle 54 and the second stirring rod 53. The second drive assembly 71 adopts a single-axis slide, and the second drive assembly 71 includes a second base 711, a second drive motor 712, a second lead screw 713 and a second slider 714. The second base 711 is connected to the outer bottom wall of the first wall body 101, and the second drive motor 712 is arranged on the lower end of the second base 711. The second lead screw 713 is rotatably connected to the second base 711 and is connected to the second drive motor 712. The second slider 714 is rotatably connected to the second lead screw 713. When the second drive motor 712 is working, it drives the second lead screw 713 to rotate, thereby driving the second slider 714 to move up and down. The second slider 714 is connected to the sealing ring 72, and is used to drive the sealing ring 72 to move up and down.

[0031] like Figure 1 , Figure 6 and Figure 8As shown, a first feed pipe 11 and a second feed pipe 12 are provided on the top wall of the kettle body 1, and the first feed pipe 11 is located above the space between the outer wall of the partition tube 2 and the inner wall of the kettle body 1, so that the material entering through the first feed pipe 11 falls outside the partition tube 2. The discharge port at the lower end of the second feed pipe 12 passes through the through hole 511, so that the discharge port at the lower end of the second feed pipe 12 is located above the partition tube 2, and the material entering through the second feed pipe 12 directly falls into the partition tube 2. A discharge pipe 13 is provided on the bottom wall of the kettle body 1, and the discharge pipe 13 is arranged on the second wall body 102, so that the discharge pipe 13 is located below the partition tube 2, and the liquid material in the kettle body 1 is discharged through the discharge pipe 13. When the various materials entering the kettle body need to be stirred separately, the second driving assembly 71 drives the sealing ring 72 to move upward, and the sealing ring 72 blocks the annular channel. At this time, the space inside the partition 2 is separated from the space outside the partition 2. At this time, the first part of the various materials that need to be stirred are put into the kettle body 1 through the first feeding pipe 11, and the first part of the materials that need to be stirred falls into the space outside the partition 2. The material liquid level height does not exceed the upper end of the partition 2, and is mixed under the stirring action of the second stirring paddle 54 and the second stirring rod 53; the second part of the various materials that need to be stirred are put into the kettle body 1 through the second feeding pipe 12, and the second part of the materials that need to be stirred falls into the space inside the partition 2. The material liquid level height does not exceed the upper end of the partition 2, and is mixed under the stirring action of the first stirring rod 42 and the first stirring paddle 41; thereby completing the separate mixing of different parts of the materials. When the materials are mixed , the sealing ring 72 is driven downward by the second driving component 71, and the annular channel is opened. The first part of the material preliminarily mixed outside the partition 2 enters the bottom of the partition 2 through the annular channel, and moves upward under the axial flow stirring action of the first stirring paddle 41 to mix with the second part of the material. At this time, the required material continues to be added to the kettle body 1 through the first feed pipe 11 or the second feed pipe 12. The material level height in the kettle body 1 exceeds the upper end of the partition 2. Under the axial flow stirring action of the first stirring paddle 41, the material in the kettle body 1 circulates three-dimensionally, and there is no sedimentation in the central part. Under the stirring action of the second stirring paddle 54 and the second stirring rod 53 revolution and rotation, the material liquid has both axial flow (driven by the first stirring paddle 41) and radial flow (driven by the revolution of the second stirring rod 53) and turbulence (the rotation of the second stirring rod 53 drives the second stirring paddle 54 to rotate), and the material mixing effect is good.

[0032] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A reactor for chemical synthesis of raw materials, characterized in that: The invention comprises a kettle body (1), a partition cylinder (2) arranged in the kettle body (1), a first driving assembly (3) arranged on the kettle body (1), a first stirring assembly (4) connected to the first driving assembly (3), and a second stirring assembly (5) connected to the first driving assembly (3); the lower end of the partition cylinder (2) is connected to the inner bottom wall of the kettle body (1) through a support rod (21); an annular channel is formed between the lower end of the partition cylinder (2) and the inner bottom wall of the kettle body (1); the first stirring assembly (4) comprises a first stirring paddle (41); the first stirring paddle (41) is located in the partition cylinder (2); and the first stirring paddle (41) drives the liquid in the partition cylinder (2) upward.

2. The reactor for chemical synthesis of raw materials according to claim 1, characterized in that: The second stirring assembly (5) is connected to the first driving assembly (3) via a transmission assembly (6); the first driving assembly (3) comprises a first driving motor (31), a driving shaft (32) connected to the first driving motor (31), and a driving gear (33) arranged on the driving shaft (32); the transmission assembly (6) comprises a first gear (61) corresponding to the driving gear (33) and a second gear (62) coaxially connected to the first driven gear (61).

3. The reactor for chemical synthesis of raw materials according to claim 2, characterized in that: The second stirring assembly (5) comprises a mounting plate (51), a first annular gear ring (52) arranged on the mounting plate (51) and corresponding to the second gear (62), a second stirring rod (53) connected to the mounting plate (51), and a second stirring paddle (54) arranged on the second stirring rod (53); an annular slide rail (14) is arranged on the inner top wall of the kettle body (1); a sliding block (55) corresponding to the annular slide rail (14) is arranged on the mounting plate (51); and the mounting plate (51) is rotatably connected to the kettle body (1) via the annular slide rail (14).

4. The reactor for chemical synthesis of raw materials according to claim 3, characterized in that: The second stirring rod (53) is rotatably connected to the mounting plate (51); a third gear (531) is provided at the top end of the second stirring rod (53); and a third gear (531) and a second annular gear ring (15) corresponding to the third gear (531) are provided on the inner top wall of the kettle body (1).

5. The reactor for chemical synthesis of raw materials according to claim 1, characterized in that: A blocking component (7) for blocking the annular channel is provided on the bottom wall of the kettle body (1); the blocking component (7) comprises a second driving component (71) and a blocking ring (72) connected to the second driving component (71); the bottom wall of the kettle body (1) comprises a first wall body (101) located outside the blocking ring (72) and a second wall body (102) located inside the blocking ring (72); the second wall body (102) is connected to the blocking ring (72); the second driving component (71) drives the blocking ring (72) to move upwards to block the annular channel.

6. The reactor for chemical synthesis of raw materials according to claim 5, characterized in that: The second driving assembly (71) comprises a second base (711), a second driving motor (712) arranged on the second base (711), a second lead screw (713) connected to the second driving motor (712), and a second slider (714) movably connected to the second lead screw (713), and the second slider (714) is connected to the sealing ring (72).

7. The reactor for chemical synthesis of raw materials according to claim 3, characterized in that: The first stirring assembly (4) further comprises a first stirring rod (42) connected to the driving shaft (32); the first stirring paddle (41) is arranged on the first stirring rod (42); and the mounting plate (51) is provided with a through hole (511) for the first stirring rod (42) to pass through.

8. The reactor for chemical synthesis of raw materials according to claim 7, characterized in that: The kettle body (1) is provided with a first feed pipe (11) and a second feed pipe (12), and the bottom wall of the kettle body (1) is provided with a discharge pipe (13). The discharge port at the lower end of the second feed pipe (12) is located above the partition cylinder (2), and the material entering through the second feed pipe (12) directly falls into the partition cylinder (2). The discharge pipe (13) is located below the partition cylinder (2).

9. The reactor for chemical synthesis of raw materials according to claim 1, characterized in that: An annular slope (16) with high sides and low center is provided on the inner bottom wall of the kettle body (1), and the height of the annular slope (16) gradually decreases from the inner side wall of the kettle body (1) toward the annular channel.

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