Veterinary fluralan solution
By using N,N-dimethylacetamide, N,N-dimethylformamide, nonylphenol polyoxyethylene ether and lauriazole ketone in veterinary medicine, a type of cerebrosina is formed. The use of Frerana solution has solved the problems of dissolution difficulties, safety hazards and low bioavailability, and achieved higher stability, safety and rapid effect.
Patent Information
- Application Number
- CN202411761756.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-03
- Publication Date
- 2025-02-11
AI Technical Summary
The existing veterinary dosage forms of Frerana have problems with dissolution difficulties, solvent safety risks and low bioavailability.
N,N-dimethylacetamide and/or N,N-dimethylformamide as co-solvent, nonylphenol polyoxyethylene ether and/or laurazole ketone as penetration agent to form a kind of animal Use Frerana solution.
It improves the boiling point of the solvent and the stability and safety of the preparation, ensures the safety of the drug on animal skin and hair, and improves the bioavailability of the flurerana drug, so that the drug can take effect quickly.
Abstract
Description
Technical Field
[0001] The invention relates to the technical field of veterinary drugs, and in particular to a veterinary flurellan solution. Background Art
[0002] Fluoranab is a broad-spectrum insecticide with good insecticidal activity against pests such as Ticks, Siphonaptera, Pediculus, Hemiptera and Diptera, and its toxicity is higher than or equivalent to that of commonly used insecticides. Fluoranab not only has no significant cross-resistance with existing insecticides, but also has good insecticidal activity against some resistant pests. Fluoranab is insoluble in water, and the current dosage form is mostly chewable tablets, which makes it difficult to administer to pets. At present, some imported products have adopted acetone low-boiling point solvents. If this solvent leaks during production, storage and transportation, there are great safety hazards. In addition, acetone is a controlled material in my country, so it is not easy to obtain. Summary of the invention
[0003] The invention provides a veterinary flurellan solution, which improves the boiling point of the solvent and the stability and safety of the preparation, and its usage and dosage are safe and do not damage the skin and hair of animals, and the drug can take effect quickly and improve the bioavailability of the flurellan drug in the flurellan solution.
[0004] In order to achieve the above object, the present invention provides the following technical solution: a veterinary flurellan solution, comprising a co-solvent and a penetrant; the co-solvent is composed of N,N-dimethylacetamide and / or N,N-dimethylformamide.
[0005] Preferably, the penetrant is composed of nonylphenol polyoxyethylene ether and / or laurocapram.
[0006] Preferably, the co-solvent accounts for 25-78% of the total weight of the veterinary flurellan solution.
[0007] Preferably, the osmotic agent accounts for 1%-30% of the total weight of the veterinary flurellan solution.
[0008] Preferably, the penetrant is composed of nonylphenol polyoxyethylene ether and laurocapram, and the amount of the nonylphenol polyoxyethylene ether is 1%-20%, and the amount of the laurocapram is 0.5%-10%.
[0009] Preferably, it comprises at least three components of the N,N-dimethylacetamide, the N,N-dimethylformamide, the nonylphenol polyoxyethylene ether and laurocapram.
[0010] The beneficial effects of the present invention are as follows: N,N-dimethylacetamide and N,N-dimethylformamide in the formula solve the problem of dissolution of the drug flurellan, and can prepare a solution preparation, thereby improving the boiling point of the solvent in the preparation and the stability and safety of the preparation; the usage and dosage of the solvent in the formula are safe for animal skin and hair and are not damaged; at the same time, the usage and dosage of the auxiliary agents nonylphenol polyoxyethylene ether and laurocapram solve the problem of wettability and permeability of the flurellan drug in the flurellan solution to the animal skin, thereby enabling the drug to take effect quickly and improving the bioavailability of the flurellan drug in the flurellan solution. DETAILED DESCRIPTION
[0011] The technical solution of the present invention is described clearly and completely below. Obviously, the described embodiments are only a part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
[0012] A veterinary flurellan solution comprises a cosolvent and a penetrant; the cosolvent is composed of N,N-dimethylacetamide and / or N,N-dimethylformamide; and the penetrant is composed of nonylphenol polyoxyethylene ether and / or laurocapram.
[0013] The N,N-dimethylacetamide and N,N-dimethylformamide in the formula solve the problem of dissolution of the drug flurana, and can prepare a solution preparation, thereby improving the boiling point of the solvent in the preparation and the stability and safety of the preparation. The usage and dosage of the solvent in this formula are safe for animal skin and hair without damaging them. At the same time, the usage and dosage of the auxiliary agents nonylphenol polyoxyethylene ether and laurocapram solve the problem of wettability and permeability of the flurana drug in the flurana solution to animal skin, so that the drug can take effect quickly and improve the bioavailability of the flurana drug in the flurana solution.
[0014] The co-solvent accounts for 25-78% of the total weight of the veterinary flurellana solution, and the penetrant accounts for 1%-30% of the total weight of the veterinary flurellana solution. The penetrant is composed of nonylphenol polyoxyethylene ether and laurocapram, and the amount of the nonylphenol polyoxyethylene ether is 1%-20%, and the amount of the laurocapram is 0.5%-10%.
[0015] As a preferred solution, the veterinary flurellana solution can also be prepared using the following mass ratio:
[0016] 1. N,N-dimethylacetamide and N,N-dimethylformamide 25-78%, plus nonylphenol polyoxyethylene ether 1-20%.
[0017] 2. N,N-dimethylacetamide and N,N-dimethylformamide 25-78%, plus lauryl nitrogen Ketone 0.5-10%.
[0018] 3. N,N-dimethylacetamide 25-78%, nonylphenol polyoxyethylene ether 1-20%, plus lauryl nitrogen Ketone 0.5-10%.
[0019] 4. N,N-dimethylformamide 25-78%, nonylphenol polyoxyethylene ether 1-20%, lauryl nitrogen Ketone 0.5-10%.
[0020] Through the above-mentioned matching scheme, the veterinary flurana solution can also meet certain technical requirements in terms of increasing the boiling point and increasing the safety.
[0021] The above is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art can easily think of changes or substitutions within the technical scope disclosed by the present invention, which should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.
Claims
1. A veterinary flurellan solution, characterized in that: The invention comprises a co-solvent and a penetrant; the co-solvent is composed of N,N-dimethylacetamide and / or N,N-dimethylformamide.
2. The veterinary flurellan solution according to claim 1, characterized in that: The penetrant is composed of nonylphenol polyoxyethylene ether and / or laurocapram.
3. The veterinary flurellan solution according to claim 1, characterized in that: The co-solvent accounts for 25-78% of the total weight of the veterinary flurellan solution.
4. The veterinary flurellan solution according to claim 2, characterized in that: The osmotic agent accounts for 1%-30% of the total weight of the veterinary flurellan solution.
5. The veterinary flurellan solution according to claim 1, characterized in that: The penetrant is composed of nonylphenol polyoxyethylene ether and laurocapram, and the dosage of the nonylphenol polyoxyethylene ether is 1%-20%, and the dosage of the laurocapram is 0.5%-10%.
6. The veterinary flurellan solution according to claim 2, characterized in that: It comprises at least three components of the N,N-dimethylacetamide, the N,N-dimethylformamide, the nonylphenol polyoxyethylene ether and laurocapram.