Polypeptide solid-phase reaction kettle

Abstract

The invention relates to a polypeptide solid-phase reaction kettle, and belongs to the technical field of polypeptide preparation equipment, the polypeptide solid-phase reaction kettle comprises a kettle body and a stirring shaft arranged in the kettle body, the side surface of the bottom of the kettle body is provided with an adapter, the stirring shaft is provided with a stirring plate, and the top of the kettle body is provided with a stirring motor for driving the stirring shaft to rotate; a scraping plate is hinged to the inner side of the kettle body, the initial position of the scraping plate is horizontal, a notch is formed in the end, facing the hinged end, of the scraping plate, the stirring shaft is located in the notch, and a first driving piece used for driving the scraping plate to rotate to be attached to the inner wall of the kettle body is arranged in the kettle body; a spraying pipe is arranged on the inner side of the kettle body and is used for conveying cleaning water to wash the inner side of the kettle body; the stirring plate is movably arranged on the stirring shaft, when the stirring plate performs stirring operation, the stirring surface of the stirring plate is parallel to the stirring shaft, when the stirring plate is cleaned, the stirring surface of the stirring plate is perpendicular to the stirring shaft, and the first driving device is used for driving the stirring plate to move. The cleaning device has the effect of improving the cleaning efficiency of the reaction kettle.

Description

Technical Field

[0001] The present application relates to the technical field of polypeptide preparation equipment, and in particular to a polypeptide solid phase reaction kettle. Background Art

[0002] Peptides are widely present in organisms. So far, tens of thousands of peptides have been found in organisms. They are widely involved in and regulate the functional activities of various systems, organs, tissues and cells in the body. They have the characteristics of small dosage, strong biological activity, significant therapeutic effect and wide application, and play an important role in life activities. With the rapid development of molecular biology and biochemical technology, the research on peptides has made amazing and epoch-making progress. At present, there is a broad space for development in the fields of therapeutic drugs, diagnostic drugs, vaccines, drug carriers or antibody coupling, health products, cosmetics, etc.

[0003] Reactor is a commonly used reaction equipment in peptide solid phase synthesis. It mainly realizes the heating, evaporation, cooling and low-speed mixing functions required by the process through the structural design and parameter configuration of the container. The reactor usually includes a reactor body, the upper end of which is connected to an upper cover, on which are provided a feeding and exhaust port, a reaction liquid inlet, a sight glass and a spray washing port, and a stirring motor is provided in the middle of the upper cover; the spray washing port is connected to the spray pipe; the stirring motor is fixedly connected to the stirring paddle; a filter screen plate 1 is provided below the stirring paddle, and a load-bearing support plate is provided at the bottom of the filter screen plate 1; the lower end of the reactor body is connected to a lower cover, on which are provided a spare port, a reaction liquid outlet and a nitrogen inlet; a heat exchange jacket is coaxially provided on the outside of the reactor body, and external circulation ports extending to the outside of the heat exchange jacket are symmetrically provided on both sides of the reactor body, and a filter screen plate 2 is provided on the external circulation port; the external circulation ports on both sides of the reactor body are connected through an external circulation pipeline, and the external circulation pipeline is connected to an external circulation pump and a plate heat exchanger.

[0004] However, after the polypeptide is synthesized in the reactor, the reactor body and the stirring paddle need to be disassembled for cleaning, resulting in a relatively low cleaning efficiency of the reactor. Summary of the invention

[0005] In order to improve the cleaning efficiency of a reaction kettle, the present application provides a polypeptide solid phase reaction kettle.

[0006] The polypeptide solid phase reactor provided in this application adopts the following technical solution: A polypeptide solid phase reaction kettle, comprising a kettle body and a stirring shaft arranged in the kettle body, a transfer interface is arranged on the side of the bottom of the kettle body, the transfer interface is used to connect a delivery pipe, and transfer the mixed solution in the kettle body to a drying tank through a delivery pump, a stirring plate is arranged on the stirring shaft, and a stirring motor for driving the stirring shaft to rotate is arranged on the top of the kettle body; a scraper is hingedly arranged on the inner side of the kettle body, the scraper is initially horizontal, a notch is opened at the end of the scraper toward the hinged end, the stirring shaft is located in the notch, a first driving member for driving the scraper to rotate and attached to the inner wall of the kettle body is arranged in the kettle body; a spray pipe is arranged on the inner side of the kettle body, and the spray pipe is used to transport cleaning water to wash the inner side of the kettle body; the stirring plate is movably arranged on the stirring shaft, when the stirring plate is in stirring operation, the stirring surface of the stirring plate is parallel to the stirring shaft, and when the stirring plate is cleaned, the stirring surface of the stirring plate is perpendicular to the stirring shaft, and also includes a first driving device for driving the stirring plate to move.

[0007] Optionally, the spray pipe includes multiple tube bodies, which are arc-shaped and consistent with the curvature of the inner side of the kettle body. Connecting rods are arranged between adjacent tube bodies to connect adjacent tube bodies. The connecting rods are rotatably connected to the tube bodies. The tube bodies are rotatably arranged in the kettle body, and the tube bodies rotate along their axial directions. The tube bodies are slidably arranged in the kettle body, and the tube bodies slide along their axial directions. A second driving device for driving the tube bodies to rotate and slide is arranged in the kettle body.

[0008] Optionally, a mounting ring is provided inside the kettle body, a mounting seat is fixedly provided on the mounting ring, the scraper is hingedly provided on the mounting seat, the mounting seat includes a mounting block fixedly provided on the mounting ring and a rotating block rotatably provided on the mounting block, the rotating axis of the rotating block is perpendicular to the mounting block, the scraper is hingedly provided on the rotating block, and the first driving member is used to drive the rotating block to rotate and to drive the scraper to rotate.

[0009] Optionally, a mounting shaft is rotatably provided on the stirring shaft, the mounting shaft is perpendicular to the stirring shaft, a rotating shaft is rotatably provided on the mounting shaft, the rotating shaft is perpendicular to the mounting shaft, the stirring plate is fixedly provided on the rotating shaft, and the first driving device is used to drive the mounting shaft to rotate and to drive the rotating shaft to rotate.

[0010] Optionally, the first driving device includes a first micro motor embedded in the mounting shaft, and the rotating shaft is coaxially arranged on the output shaft of the first micro motor; the first driving device also includes a first electric push rod arranged on the stirring shaft, and a driving plate is coaxially arranged on the output shaft of the first electric push rod, the mounting shaft is perpendicular to the driving plate and abuts against the driving plate, and the first electric push rod pulls the driving plate to move and drives the mounting shaft to rotate.

[0011] Optionally, a rack is provided on the driving plate, and a gear meshing with the rack is sleeved on the mounting shaft.

[0012] Optionally, a mounting groove is provided on the stirring shaft, and the mounting groove is provided along the length direction of the stirring shaft. The driving plate and the mounting shaft are both located in the mounting groove, and the bottom of the mounting groove is inclined toward the bottom of the kettle body and connected with the outer wall of the stirring shaft.

[0013] Optionally, a water inlet hole is opened on the side wall of the stirring shaft, and the water inlet hole is connected to the mounting groove. The cleaning water sprayed by the spray pipe enters the mounting groove through the water inlet hole to rinse the rack and the rack.

[0014] Optionally, flow channels are provided on both sides of the stirring surface of the stirring plate, and the flow channels penetrate the stirring plate along the length direction of the stirring plate. The flow channels face the gears, and the cleaning water on the stirring plate flows along the flow channels to flush the gears and racks.

[0015] Optionally, the mounting ring is rotatably disposed in the kettle body, and the mounting ring slides along the axial direction of the kettle body. The rotation of the mounting ring drives the mounting seat to move and drives the scraper to move to scrape the inner wall of the kettle body.

[0016] In summary, the present application includes at least one of the following beneficial technical effects: After the polypeptide is prepared in the kettle, the resin mixed solution is transferred to the filter bag of the drying tank through the pump system. The solvent after the resin mixed solution is filtered through the filter bag and filter plate in the drying tank can be returned to the reactor through the pump system; After the material in the kettle body is transferred, cleaning water is sprayed out through the spray pipe, the cleaning water is sprayed into the kettle body, and the inner wall of the kettle body and the stirring shaft are washed to improve the cleaning efficiency of the kettle body; at the same time, the scraper is driven by the first driving member to move and fit the inner wall of the kettle body, and the scraper is driven to move along the inner wall of the kettle body, and the scraper scrapes off the residue attached to the inner wall of the kettle body, and the scraped residue is discharged from the kettle body driven by the cleaning water; at the same time, when the spray pipe sprays cleaning water, the stirring plate is driven by the first driving device to move, and the stirring plate rotates to face the inner wall of the kettle body and the spray pipe, and the sprayed cleaning water is washed to the stirring plate, and the residue attached to the stirring plate is washed, thereby improving the cleaning effect of the stirring plate; when the stirring plate plays a stirring role, the first driving device drives the stirring plate to move parallel to the stirring shaft, so as to facilitate the stirring of the material; When the stirring plate is flushed, the stirring plate is moved so as to face the spray pipe to the maximum extent, which further improves the cleaning effect of the stirring plate and thus improves the cleaning efficiency of the reactor. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is a schematic diagram of the connection between a polypeptide solid phase reaction kettle and a drying tank in an embodiment of the present application; Figure 2 This is a cross-sectional view of a kettle body in a polypeptide solid phase reaction kettle according to an embodiment of the present application; Figure 3 This is a side view of a polypeptide solid phase reaction kettle in an embodiment of the present application; Figure 4 It is a cross-sectional view of a mounting seat in a polypeptide solid phase reaction kettle according to an embodiment of the present application; Figure 5 It is a cross-sectional view of a stirring shaft in a polypeptide solid phase reaction kettle according to an embodiment of the present application; Figure 6 yes Figure 5 Enlarged schematic diagram of part A.

[0018] Description of reference numerals: 1, kettle body; 2, stirring shaft; 3, adapter; 4, delivery pipe; 5, delivery pump; 6, drying tank; 7, stirring plate; 8, stirring motor; 9, scraper; 10, notch; 11. first driving member; 111. second motor; 12. Sprinkler pipe; 121. Pipe body; 122. Sprinkler head; 123. Connecting rod; 13. first driving device; 131. first micro motor; 132. first electric push rod; 133. driving plate; 134. rack; 135. gear; 14. Mounting shaft; 15. Rotating shaft; 16. Mounting groove; 17. Water inlet hole; 18. Flow channel; 19. second driving device; 191. first motor; 192. first driving wheel; 193. second electric push rod; 20. Mounting ring; 21. Mounting seat; 211. Mounting block; 212. Rotating block; 22. Fourth motor; 23. Second drive wheel. DETAILED DESCRIPTION

[0019] The following is combined with Figure 1 -Attached Figure 6 This application is described in further detail.

[0020] The present application example discloses a polypeptide solid phase reaction kettle. Figure 1 and Figure 2The polypeptide solid phase reaction kettle comprises a kettle body 1 and a stirring shaft 2 arranged in the kettle body 1. A transfer port 3 is arranged on the side of the bottom of the kettle body 1. The transfer port 3 is used to connect a delivery pipe 4 and transfer the mixed solution in the kettle body 1 to a drying tank 6 through a delivery pump 5. A stirring plate 7 is arranged on the stirring shaft 2. A stirring motor 8 for driving the stirring shaft 2 to rotate is arranged on the top of the kettle body 1. The resin mixed solution in the kettle body 1 drives the stirring shaft 2 to rotate through the stirring motor 8, and the stirring shaft 2 drives the stirring plate 7 to rotate to stir the mixed material. The mixed material after stirring is transferred to the filter bag of the drying tank 6 through the transfer port 3 through the pump system. The solvent after the resin mixed solution is filtered through the filter bag and the filter plate in the drying tank 6 can be returned to the reactor through the pump system. Reference Figure 3 and Figure 4 In order to facilitate the cleaning of the inside of the kettle body 1, a scraper 9 is hingedly provided on the inner side of the kettle body 1. The initial position of the scraper 9 is horizontal. A notch 10 is provided at the end of the scraper 9 toward the hinged end. The stirring shaft 2 is located in the notch 10. A first driving member 11 is provided in the kettle body 1 for driving the scraper 9 to rotate and is attached to the inner wall of the kettle body 1; a spray pipe 12 is provided on the inner side of the kettle body 1, and the spray pipe 12 is used to transport cleaning water to rinse the inner side of the kettle body 1; a stirring plate 7 is movably provided on the stirring shaft 2. When the stirring plate 7 is stirring, the stirring surface of the stirring plate 7 is parallel to the stirring shaft 2. When the stirring plate 7 is cleaning, the stirring surface of the stirring plate 7 is perpendicular to the stirring shaft 2. A first driving device 13 for driving the stirring plate 7 to move is also included.

[0021] After the material in the kettle body 1 is transferred, the cleaning water is sprayed out through the spray pipe 12, the cleaning water is sprayed into the kettle body 1, and the inner wall of the kettle body 1 and the stirring shaft 2 are washed to improve the cleaning efficiency of the kettle body 1; at the same time, the scraper 9 is driven by the first driving member 11 to move and fit to the inner wall of the kettle body 1, and the scraper 9 is driven to move along the inner wall of the kettle body 1, and the scraper 9 scrapes off the residue attached to the inner wall of the kettle body 1, and the scraped residue is discharged from the kettle body 1 under the drive of the cleaning water; at the same time, when the spray pipe 12 sprays the cleaning water, the stirring plate 7 is driven to move by the first driving device 13, and the stirring plate 7 rotates to face the inner wall of the kettle body 1 and the spray pipe 12, and the sprayed cleaning water is washed to the stirring plate 7, and the residue attached to the stirring plate 7 is washed, thereby improving the cleaning effect of the stirring plate 7; when the stirring plate 7 plays a stirring role, the first driving device 13 drives the stirring plate 7 to move parallel to the stirring shaft 2, so as to facilitate the stirring of the material.

[0022] Reference Figure 4 , Figure 5 and Figure 6In the embodiment of the present application, a mounting shaft 14 is rotatably provided on the stirring shaft 2, the mounting shaft 14 is perpendicular to the stirring shaft 2, the rotation axis of the mounting shaft 14 is perpendicular to the length direction of the stirring shaft 2, a rotating shaft 15 is rotatably provided on the mounting shaft 14, the rotating shaft 15 is perpendicular to the mounting shaft 14, and the stirring plate 7 is fixedly provided on the rotating shaft 15. Further, the first driving device 13 is used to drive the mounting shaft 14 to rotate and to drive the rotating shaft 15 to rotate. The first driving device 13 includes a first micro motor 131 embedded in the mounting shaft 14, the rotating shaft 15 is coaxially provided on the output shaft of the first micro motor 131, the first micro motor 131 drives the rotating shaft 15 to rotate, and the rotating shaft 15 drives the stirring plate 7 to rotate to adjust the direction of the stirring surface of the stirring plate 7; the first driving device 13 also includes The first electric push rod 132 is arranged on the stirring shaft 2, and a driving plate 133 is coaxially arranged on the output shaft of the first electric push rod 132. The mounting shaft 14 is perpendicular to the driving plate 133 and abuts against the driving plate 133. The first electric push rod 132 pulls the driving plate 133 to move and drives the mounting shaft 14 to rotate; start the first electric push rod 132, the first electric push rod 132 pulls the driving plate 133 to slide back and forth along the stirring shaft 2, the sliding of the driving plate 133 drives the mounting shaft 14 to rotate back and forth, and the reciprocating rotation of the mounting shaft 14 drives the stirring plate 7 to swing, so that the stirring plate 7 is facing the spray pipe 12; at the same time, when the stirring shaft 2 drives the stirring plate 7 to stir the material, the first electric push rod 132 drives the stirring plate 7 to swing back and forth, thereby improving the stirring effect on the material.

[0023] Reference Figure 5 and Figure 6 In order to facilitate the driving plate 133 to drive the installation shaft 14 to rotate, a rack 134 is provided on the driving plate 133, and a gear 135 meshing with the rack 134 is sleeved on the installation shaft 14; the driving plate 133 drives the rack 134 to move, and the movement of the rack 134 drives the gear 135 to rotate, and the gear 135 drives the installation shaft 14 to rotate, thereby facilitating the driving plate 133 to drive the installation shaft 14 to rotate.

[0024] Reference Figure 5 and Figure 6In order to facilitate the installation of the mounting shaft 14 on the stirring shaft 2, a mounting groove 16 is provided on the stirring shaft 2, and the mounting groove 16 is provided along the length direction of the stirring shaft 2. The driving plate 133 and the mounting shaft 14 are both located in the mounting groove 16, and the bottom of the mounting groove 16 is inclined toward the bottom of the kettle body 1 and connected with the outer wall of the stirring shaft 2; both ends of the mounting shaft 14 are rotatably arranged on the inner wall of the mounting groove 16, so as to facilitate the installation of the mounting shaft 14, and the driving plate 133 is located in the mounting groove 16 and fits the bottom wall of the mounting groove 16 to reduce the possibility of materials entering between the stirring plate 7 and the bottom wall of the mounting groove 16, thereby reducing the difficulty of cleaning the kettle body 1; after the spray water is sprayed into the mounting groove 16, the spray water rinses the gear 135 and the rack 134, and the washing water after rinsing is removed through the inclined surface at the bottom of the mounting groove 16, thereby reducing the possibility of washing water remaining in the mounting groove 16.

[0025] Reference Figure 4 and Figure 5 In the embodiment of the present application, a water inlet hole 17 is opened on the side wall of the stirring shaft 2, and the water inlet hole 17 is connected to the mounting groove 16. The cleaning water sprayed from the spray pipe 12 enters the mounting groove 16 through the water inlet hole 17 to rinse the rack 134 and the gear 134; when the cleaning water is sprayed to the stirring shaft 2, part of the cleaning water enters the mounting groove 16 through the water inlet hole 17. The cleaning water that enters the mounting groove 16 through the water inlet hole 17 rinses the rack 134 and the gear 135, and rinses the gap between the driving plate 133 and the bottom wall of the mounting groove 16, thereby improving the flushing effect of the stirring shaft 2.

[0026] Reference Figure 4 and Figure 5 In order to further improve the cleaning effect of the gear 135 and the rack 134, flow channels 18 are provided on the stirring surfaces on both sides of the stirring plate 7. The flow channels 18 penetrate the stirring plate 7 along the length direction of the stirring plate 7. The flow channels 18 are directly opposite to the gear 135. The cleaning water on the stirring plate 7 flows along the flow channels 18 to wash the gear 135 and the rack 134; after the stirring plate 7 is tilted toward the inner wall of the kettle body 1, the spray water is sprayed to the stirring plate 7, and the stirring plate 7 blocks the spray water, making it difficult for the spray water to wash the gear 135. At this time, the spray water flows along the flow channels 18 and washes the gear 135, thereby improving the cleaning effect of the gear 135.

[0027] Reference Figure 2In the embodiment of the present application, the spray pipe 12 includes a plurality of pipe bodies 121, a spray head 122 is connected to the pipe body 121, the pipe body 121 is connected to the spray water delivery pipe 4, the plurality of pipe bodies 121 are arranged in a circular ring shape, the pipe body 121 is arc-shaped and has the same arc as the inner side of the kettle body 1, and a connecting rod 123 is provided between adjacent pipe bodies 121 to connect the adjacent pipe bodies 121, the connecting rod 123 is rotatably connected to the pipe body 121, the pipe body 121 is rotatably arranged in the kettle body 1, and the pipe The body 121 rotates along its axial direction, the body 121 is slidably arranged in the kettle body 1, and the body 121 slides along its axial direction. A second driving device 19 for driving the body 121 to rotate and slide is arranged in the kettle body 1. The second driving device 19 includes a second driving member for rotating the body 121 and a third driving member for driving the body 121 to slide. The second driving member includes a first motor 191 arranged on the inner wall of the kettle body 1 and a third driving member arranged on the output of the first motor 191. The first drive wheel 192 of the output shaft, the axis of the first drive wheel 192 is parallel to the tube body 121, the first drive wheel 192 is in contact with the tube body 121, the first motor 191 drives the first drive wheel 192 to rotate, the rotation of the first drive wheel 192 drives the tube body 121 to rotate, and the rotation of the tube body 121 adjusts the direction of the spray head 122. Further, the first motor 191 and the first drive wheel 192 correspond to the tube body 121 one by one, and the connecting rod 123 is rotatably connected to the tube body 121, so as to facilitate the first motor 191 to drive the tube body 121 to rotate; the third driving member includes a second electric push rod 193 arranged in the kettle body 1, any one of the connecting rods 123 is fixedly arranged on the output shaft of the second electric push rod 193, the second electric push rod 193 is started, the second electric push rod 193 pushes the connecting rod 123 to move, and the movement of the connecting rod 123 drives the tube body 121 to move, thereby adjusting the position of the tube body 121 to reduce the blank area of ​​the spray water.

[0028] Reference Figure 2 and Figure 3In the implementation of the present application, a mounting ring 20 is provided inside the kettle body 1, a mounting seat 21 is fixedly provided on the mounting ring 20, the scraper 9 is hingedly provided on the mounting seat 21, the mounting seat 21 includes a mounting block 211 fixedly provided on the mounting ring 20 and a rotating block 212 rotatably provided on the mounting block 211, the rotating block 212 is located below the mounting block 211, the rotating axis of the rotating block 212 is perpendicular to the mounting block 211, the scraper 9 is hingedly provided on the rotating block 212, the first driving member 11 is used to drive the rotating block 212 to rotate and to rotate the scraper 9, and the first driving member 11 includes a second motor 11 provided in the mounting block 211 1, the length direction of the output shaft of the second motor 111 is parallel to the depth direction of the kettle body 1, and the rotating block 212 is coaxially arranged on the output shaft of the second motor 111; further, the first driving member 11 also includes a third motor arranged on the rotating block 212, and the hinge shaft of the scraper 9 is coaxially arranged on the output shaft of the third motor; when adjusting the position of the scraper 9, the scraper 9 is first driven by the hinge shaft driven by the third motor to rotate, so that the scraper 9 is separated from the stirring shaft 2, and then the second motor 111 is started, and the second motor 111 drives the rotating block 212 to rotate, and the rotating block 212 rotates to drive the scraper 9 to abut against the inner wall of the kettle body 1, so as to facilitate the scraping of the inner wall of the kettle body 1.

[0029] Reference Figure 2 and Figure 3 Further, in the implementation of the present application, the mounting ring 20 is rotatably arranged in the kettle body 1, and the mounting ring 20 slides along the axial direction of the kettle body 1. The rotation of the mounting ring 20 drives the mounting seat 21 to move and drives the scraper 9 to move to scrape the inner wall of the kettle body 1. A fourth motor 22 is fixedly arranged on the inner wall of the kettle body 1, and a second driving wheel 23 is fixedly arranged on the output shaft of the fourth motor 22. The second driving wheel 23 is crimped on the upper part of the mounting ring 20, and the output shaft of the fourth motor 22 is perpendicular to the mounting ring 20; start the fourth motor 22, the fourth motor 22 drives the second driving wheel 23 to rotate, the second driving wheel 23 drives the mounting ring 20 to move, the movement of the mounting ring 20 drives the mounting seat 21 to move, the movement of the mounting seat 21 drives the scraper 9 to move, the scraper 9 moves to scrape the inner wall of the kettle body 1, and it is convenient to clean the inner wall of the kettle body 1.

[0030] The implementation principle of a polypeptide solid phase reaction kettle in the present application example is: After the material in the kettle body 1 is transferred, cleaning water is sprayed out through the spray pipe 12, the cleaning water is sprayed into the kettle body 1, and the inner wall of the kettle body 1 and the stirring shaft 2 are rinsed to improve the cleaning efficiency of the kettle body 1; at the same time, the scraper 9 is driven to rotate by the third motor to drive the articulated shaft, so that the scraper 9 is separated from the stirring shaft 2, and then the second motor 111 is started, and the second motor 111 drives the rotating block 212 to rotate, and the rotating block 212 rotates to drive the scraper 9 to abut against the inner wall of the kettle body 1, and then the fourth motor 22 is started, and the fourth motor 22 drives the second driving wheel 23 to rotate, and the second driving wheel 23 drives the mounting ring 20 to move, and the movement of the mounting ring 20 drives the mounting seat 21 to move, and the movement of the mounting seat 21 drives the scraper 9 to move, and the scraper 9 moves to scrape the inner wall of the kettle body 1.

[0031] The spray pipe 12 sprays cleaning water and drives the stirring plate 7 to move through the first micro motor 131. The stirring plate 7 rotates to face the inner wall of the kettle body 1 and the spray pipe 12. The sprayed cleaning water is flushed to the stirring plate 7 to flush the residue attached to the stirring plate 7, thereby improving the cleaning effect of the stirring plate 7.

[0032] At the same time, the first electric push rod 132 is started, and the first electric push rod 132 pulls the driving plate 133 to slide back and forth along the stirring shaft 2. The sliding of the driving plate 133 drives the mounting shaft 14 to rotate back and forth. The reciprocating rotation of the mounting shaft 14 drives the stirring plate 7 to swing, thereby facilitating the stirring plate 7 to face the spray pipe 12; at the same time, when the stirring shaft 2 drives the stirring plate 7 to stir the material, the first electric push rod 132 drives the stirring plate 7 to swing back and forth up and down, thereby improving the stirring effect on the material.

[0033] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. A polypeptide solid phase reaction kettle, characterized in that: The invention comprises a kettle body (1) and a stirring shaft (2) arranged in the kettle body (1); a transfer port (3) is arranged on the side of the bottom of the kettle body (1); the transfer port (3) is used to connect a delivery pipe (4) and transfer the mixed solution in the kettle body (1) to a drying tank (6) through a delivery pump (5); a stirring plate (7) is arranged on the stirring shaft (2); a stirring motor (8) for driving the stirring shaft (2) to rotate is arranged on the top of the kettle body (1); a scraper (9) is hingedly arranged on the inner side of the kettle body (1); the scraper (9) is initially horizontal; a notch (10) is provided at the end of the scraper (9) toward the hinged end; the stirring shaft (2) is located at a position The kettle (1) is provided with a first driving member (11) for driving a scraper (9) to rotate and fit against the inner wall of the kettle (1) in the notch (10); a spray pipe (12) is provided on the inner side of the kettle (1), and the spray pipe (12) is used to transport cleaning water to wash the inner side of the kettle (1); the stirring plate (7) is movably arranged on the stirring shaft (2); when the stirring plate (7) is stirring, the stirring surface of the stirring plate (7) is parallel to the stirring shaft (2); when the stirring plate (7) is cleaning, the stirring surface of the stirring plate (7) is perpendicular to the stirring shaft (2); and a first driving device (13) for driving the stirring plate (7) to move is also included.

2. A polypeptide solid phase reaction kettle according to claim 1, characterized in that: The spray pipe (12) comprises a plurality of tube bodies (121), the tube bodies (121) are arc-shaped and have the same arc as the inner side of the kettle body (1), connecting rods (123) are arranged between adjacent tube bodies (121) to connect adjacent tube bodies (121), the connecting rods (123) are rotatably connected to the tube bodies (121), the tube bodies (121) are rotatably arranged in the kettle body (1), the tube bodies (121) rotate along their axial direction, the tube bodies (121) are slidably arranged in the kettle body (1), the tube bodies (121) slide along their axial direction, and a second driving device (19) for driving the tube bodies (121) to rotate and slide is arranged in the kettle body (1).

3. A polypeptide solid phase reaction kettle according to claim 1, characterized in that: A mounting ring (20) is arranged inside the kettle body (1), a mounting seat (21) is fixedly arranged on the mounting ring (20), the scraper (9) is hingedly arranged on the mounting seat (21), the mounting seat (21) comprises a mounting block (211) fixedly arranged on the mounting ring (20) and a rotating block (212) rotatably arranged on the mounting block (211), the rotating axis of the rotating block (212) is perpendicular to the mounting block (211), the scraper (9) is hingedly connected to the rotating block (212), and the first driving member (11) is used to drive the rotating block (212) to rotate and to drive the scraper (9) to rotate.

4. A polypeptide solid phase reaction kettle according to claim 1, characterized in that: The stirring shaft (2) is rotatably provided with a mounting shaft (14), the mounting shaft (14) being perpendicular to the stirring shaft (2); the mounting shaft (14) is rotatably provided with a rotating shaft (15), the rotating shaft (15) being perpendicular to the mounting shaft (14); the stirring plate (7) is fixedly provided on the rotating shaft (15); and the first driving device (13) is used for driving the mounting shaft (14) to rotate and for driving the rotating shaft (15) to rotate.

5. A polypeptide solid phase reaction kettle according to claim 4, characterized in that: The first driving device (13) comprises a first micro motor (131) embedded in the mounting shaft (14), and the rotating shaft (15) is coaxially arranged on the output shaft of the first micro motor (131); the first driving device (13) further comprises a first electric push rod (132) arranged on the stirring shaft (2), a driving plate (133) is coaxially arranged on the output shaft of the first electric push rod (132), the mounting shaft (14) is perpendicular to the driving plate (133) and abuts against the driving plate (133), and the first electric push rod (132) pulls the driving plate (133) to move and drives the mounting shaft (14) to rotate.

6. A polypeptide solid phase reaction kettle according to claim 5, characterized in that: The driving plate (133) is provided with a rack (134), and the mounting shaft (14) is sleeved with a gear (135) meshing with the rack (134).

7. A polypeptide solid phase reaction kettle according to claim 6, characterized in that: The stirring shaft (2) is provided with a mounting groove (16), the mounting groove (16) being provided along the length direction of the stirring shaft (2), the driving plate (133) and the mounting shaft (14) being both located in the mounting groove (16), and the bottom of the mounting groove (16) being inclined toward the bottom of the kettle body (1) and connected with the outer wall of the stirring shaft (2).

8. A polypeptide solid phase reaction kettle according to claim 6, characterized in that: A water inlet hole (17) is provided on the side wall of the stirring shaft (2), and the water inlet hole (17) is connected to the mounting groove (16). The cleaning water sprayed by the spray pipe (12) enters the mounting groove (16) through the water inlet hole (17) to wash the rack (134) and the rack (134).

9. A polypeptide solid phase reaction kettle according to claim 6, characterized in that: The stirring surfaces on both sides of the stirring plate (7) are provided with flow channels (18), the flow channels (18) penetrate the stirring plate (7) along the length direction of the stirring plate (7), the flow channels (18) are directly opposite to the gear (135), and the cleaning water on the stirring plate (7) flows along the flow channels (18) to wash the gear (135) and the rack (134).

10. A polypeptide solid phase reaction kettle according to claim 3, characterized in that: The mounting ring (20) is rotatably arranged in the kettle body (1), and the mounting ring (20) slides along the axial direction of the kettle body (1). The rotation of the mounting ring (20) drives the mounting seat (21) to move, thereby driving the scraper (9) to move to scrape the inner wall of the kettle body (1).

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