Oil-control shampoo and preparation method thereof

Abstract

The invention relates to the technical field of cosmetics, in particular to oil-control shampoo and a preparation method thereof. The oil control shampoo is prepared from the following components in parts by weight: 10 to 35 parts of a surfactant, 0.8 to 15 parts of a hair conditioner, 0.02 to 0.35 part of a cationic conditioner, 0.05 to 0.2 part of a chelating agent, 0.1 to 1 part of a rheology regulator and 50 to 70 parts of water, the hair conditioner is prepared from the following components in parts by weight: 0.3 to 5 parts of herba dendrobii sodium hyaluronate extract and 0.5 to 10 parts of platycladus orientalis extract. The dendrobe sodium hyaluronate extract and the platycladus orientalis extract are adopted and can achieve a synergistic effect with the cationic conditioner, so that the addition amount of the cationic polymer conditioner is reduced, the dry and wet combability of the shampoo during use is improved, and a long-acting oil control effect is achieved.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetics, and in particular to an oil-control shampoo and a preparation method thereof. Background Art

[0002] At present, silicone-free shampoo is a high-end hair care product. After removing silicone from the shampoo ingredients, a series of problems will occur during use, such as uneven rinsing, tangled hair, and dry hair. Commercially available silicone-free shampoo uses cationic polymer conditioning agents to replace silicone oil to achieve a softening effect. In order to achieve a softening effect, the amount of cationic polymer conditioning agents added is relatively high, and some contents are as high as about 0.5%. However, due to the stronger adsorption of cationic polymers, cations and the chemicals they carry are easily accumulated on the scalp and hair, causing the pores of the scalp to be blocked, affecting the oxygen permeability of the scalp and causing the hair papilla to gradually shrink, which in turn leads to a series of problems such as hair loss, increased oil production, itchy scalp, and dandruff.

[0003] In view of this, the present invention is proposed. Summary of the invention

[0004] One object of the present invention is to provide an oil-control shampoo that can ensure smoothness and long-lasting oil control while improving its wet and dry combing properties during use.

[0005] Another object of the present invention is to provide a method for preparing the oil-control shampoo.

[0006] In order to achieve the above-mentioned object of the present invention, the present invention provides an oil-control shampoo on one hand, comprising the following components in parts by weight:

[0007] 10-35 parts of surfactant, 0.8-15 parts of hair conditioning agent, 0.02-0.35 parts of cationic conditioning agent, 0.05-0.2 parts of chelating agent, 0.1-1 parts of rheology modifier and 50-70 parts of water;

[0008] The hair conditioning agent comprises 0.3-5 parts of sodium hyaluronate extract of dendrobium and 0.5-10 parts of orientalis extract by weight.

[0009] In a specific embodiment of the present invention, the Dendrobium sodium hyaluronate extract comprises Dendrobium stem extract, sodium hyaluronate and hydrolyzed sodium hyaluronate.

[0010] In a specific embodiment of the present invention, the mass ratio of the sodium hyaluronate to the hydrolyzed sodium hyaluronate and to the Dendrobium stem extract is (0.1-1):(25-50); the mass ratio of the sodium hyaluronate to the hydrolyzed sodium hyaluronate is (3-15):(5-12). Wherein, the molecular weight of the hydrolyzed sodium hyaluronate is less than 1wDa.

[0011] In a specific embodiment of the present invention, the sodium hyaluronate comprises a high molecular weight sodium hyaluronate of 100w-180wDa and a low molecular weight sodium hyaluronate of 20w-40wDa. Further, the sodium hyaluronate comprises a high molecular weight sodium hyaluronate and a low molecular weight sodium hyaluronate in a mass ratio of (1-5):(2-10).

[0012] In a specific embodiment of the present invention, the Platycladus orientalis extract includes isoquercetin, afudamidin, aconitum biflavonoids, koreanolide and dextrorotatory quinic acid;

[0013] The mass ratio of the isoquercetin, the afusadrin, the aconitum biflavonoids, the koreanolide and the dextrorotatory quinic acid is 1:(2-2.7):(3.5-5):(2-2.6):(650-890).

[0014] In a specific embodiment of the present invention, in the Platycladus orientalis extract, the percentages of isoquercetin, afudamidin and aconitum biflavonoids in the total flavonoids are 0.30% to 1.00%, 0.20% to 1.90% and 3.50% to 3.90% respectively.

[0015] In a specific embodiment of the present invention, the Platycladus orientalis extract further comprises at least one of propylene glycol and butylene glycol. Further, the Platycladus orientalis extract further comprises PEG-40 hydrogenated castor oil and / or disodium EDTA.

[0016] In a specific embodiment of the present invention, in the Platycladus orientalis extract, the mass fraction of the PEG-40 hydrogenated castor oil is 0.2% to 0.6%, and the mass fraction of the disodium EDTA is 0.1% to 0.2%.

[0017] In a specific embodiment of the present invention, the preparation of the Platycladus orientalis extract comprises:

[0018] (a) using ethanol aqueous solution as the extraction solvent, with a solid-liquid ratio of 1:10 to 1:30, and extracting Platycladus orientalis leaves at 25 to 85°C for 1 to 3 hours;

[0019] (b) adjusting the pH of the extract obtained by the extraction to 8.3-9.5, stirring the extract, filtering the extract, and then adjusting the pH to 7.0±0.5.

[0020] In a specific embodiment of the present invention, the preparation of the Platycladus orientalis extract further comprises: concentrating the material adjusted to pH 7.0±0.5, and re-dissolving it with a propylene glycol aqueous solution or a butylene glycol aqueous solution. Further, adding PEG-40 hydrogenated castor oil and / or disodium EDTA to the re-dissolved material.

[0021] In a specific embodiment of the present invention, the mass ratio of the Dendrobium officinale sodium hyaluronate extract to the Platycladus orientalis extract is 1:(1-6).

[0022] In a specific embodiment of the present invention, the oil-control shampoo further comprises at least one of a pH regulator, a fragrance and a preservative. Further, the oil-control shampoo further comprises the following components by weight: 0 to 0.5 parts of a pH regulator, 0 to 1.5 parts of a fragrance and 0.1 to 0.8 parts of a preservative.

[0023] In a specific embodiment of the present invention, the surfactant comprises the following components by weight: 10 to 25 parts of a main surfactant and 0 to 10 parts of an auxiliary surfactant. Further, the main surfactant comprises sodium laureth sulfate and / or ammonium laureth sulfate; the auxiliary surfactant comprises at least one of lauryl hydroxysulfobetaine, cocamidopropyl betaine, sodium cocoamphoacetate and cocamide MEA.

[0024] In a specific embodiment of the present invention, the cationic conditioning agent includes at least one of guar hydroxypropyltrimonium chloride, polyquaternium-10 and polyquaternium-39. Furthermore, in the oil-control shampoo, the mass fraction of the cationic conditioning agent is 0.02% to 0.35%.

[0025] In a specific embodiment of the present invention, the chelating agent includes at least one of disodium EDTA, trisodium EDTA, tetrasodium EDTA and sodium glucoheptonate.

[0026] In a specific embodiment of the present invention, the rheology modifier includes at least one of sodium chloride, trihydroxystearin, carbomer 2020, acrylic copolymer, trihydroxystearin, ammonium xylene sulfonate, polyethylene glycol-14M and silica.

[0027] In a specific embodiment of the present invention, the pH adjuster includes at least one of citric acid, sodium citrate and sodium hydroxide.

[0028] In a specific embodiment of the present invention, the preservative includes at least one of phenoxyethanol, ethylhexylglycerin, chlorphenesin, methylchloroisothiazolinone, methylisothiazolinone and sodium benzoate.

[0029] Another aspect of the present invention provides a method for preparing any one of the above-mentioned oil-control shampoos, comprising the following steps: mixing the components in proportion.

[0030] In a specific embodiment of the present invention, the following steps are included:

[0031] (A) mixing water, a chelating agent and a cationic conditioning agent in proportion and dissolving them, then adding a surfactant, heating to 80-85° C. and stirring until dissolved;

[0032] (B) Cooling the material obtained in step (A) to below 45°C, adding the remaining materials and stirring evenly.

[0033] Compared with the prior art, the present invention has the following beneficial effects:

[0034] (1) The present invention uses the sodium hyaluronate extract of Dendrobium officinale and the Platycladus orientalis extract to achieve a synergistic softening and synergistic effect with the cationic conditioning agent, thereby reducing the amount of cationic polymer conditioning agent added, improving the dry and wet combing properties of the shampoo when used, and achieving a long-lasting oil control effect; and the sodium hyaluronate extract of Dendrobium officinale can act on the scalp to moisturize the scalp, preventing excessive cleaning of the scalp from causing dry hair and dandruff;

[0035] (2) The preparation method of the oil-control shampoo of the present invention is simple to operate, requires mild conditions, and the obtained product has good stability. DETAILED DESCRIPTION

[0036] The technical scheme of the present invention will be clearly and completely described below in conjunction with specific embodiments, but it will be appreciated by those skilled in the art that the following described embodiments are part of embodiments of the present invention, rather than all embodiments, and are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative work, all belong to the scope of protection of the present invention. If specific conditions are not indicated in the embodiments, they are carried out according to normal conditions or conditions recommended by the manufacturer. If the manufacturer is not indicated in the reagents or instruments used, they are all conventional products that can be purchased commercially.

[0037] In one aspect, the present invention provides an oil-control shampoo comprising the following components in parts by weight:

[0038] 10-35 parts of surfactant, 0.8-15 parts of hair conditioning agent, 0.02-0.35 parts of cationic conditioning agent, 0.05-0.2 parts of chelating agent, 0.1-1 parts of rheology modifier and 50-70 parts of water;

[0039] The hair conditioning agent comprises 0.3-5 parts of sodium hyaluronate extract of dendrobium and 0.5-10 parts of orientalis extract by weight.

[0040] The present invention uses the sodium hyaluronate extract of dendrobium and the arborvitae extract to achieve a synergistic softening and synergistic effect with the cationic conditioner, thereby reducing the amount of cationic polymer conditioner added, improving the wet and dry combing properties of the shampoo when used, and achieving a long-lasting oil control effect; in addition, the sodium hyaluronate extract of dendrobium can act on the scalp to moisturize the scalp, preventing excessive cleaning of the scalp from causing dry hair and dandruff.

[0041] For example, in different embodiments, the amounts of the components in the oil control shampoo can be as follows by weight:

[0042] The amount of the surfactant can be 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts or a range consisting of any two of them;

[0043] The amount of the Dendrobium sodium hyaluronate extract can be 0.3 parts, 0.5 parts, 1 parts, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts or a range consisting of any two of them;

[0044] The amount of the Platycladus orientalis extract can be 0.5 parts, 1 parts, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts or a range consisting of any two of them;

[0045] The amount of the cationic conditioning agent can be 0.02 parts, 0.05 parts, 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, 0.3 parts, 0.35 parts or a range consisting of any two thereof;

[0046] The amount of the chelating agent can be 0.05 parts, 0.1 parts, 0.15 parts, 0.2 parts or a range consisting of any two of them;

[0047] The amount of the rheology modifier can be 0.1 part, 0.2 part, 0.5 part, 0.8 part, 1 part or a range consisting of any two thereof;

[0048] The amount of water can be 50 parts, 55 parts, 60 parts, 65 parts, 70 parts or a range consisting of any two of them.

[0049] In a specific embodiment of the present invention, the Dendrobium sodium hyaluronate extract includes Dendrobium stem extract, sodium hyaluronate and hydrolyzed sodium hyaluronate.

[0050] In a specific embodiment of the present invention, the mass ratio of sodium hyaluronate to hydrolyzed sodium hyaluronate and to Dendrobium stem extract is (0.1-1):(25-50); the mass ratio of sodium hyaluronate to hydrolyzed sodium hyaluronate is (3-15):(5-12). The molecular weight of hydrolyzed sodium hyaluronate is <1wDa.

[0051] For example, in different embodiments, the mass ratio of sodium hyaluronate to hydrolyzed sodium hyaluronate and to the stem extract of Dendrobium can be 0.1:25, 0.5:25, 1:25, 0.1:40, 0.5:40, 1:40, 0.1:50, 0.5:50 or any two of them. It should be noted that the mass ratio of sodium hyaluronate to hydrolyzed sodium hyaluronate and to the stem extract of Dendrobium refers to the ratio of sodium hyaluronate, hydrolyzed sodium hyaluronate and the stem extract of Dendrobium used to prepare the sodium hyaluronate extract of Dendrobium.

[0052] In a specific embodiment of the present invention, sodium hyaluronate includes high-molecular sodium hyaluronate with a molecular weight of 100w-180wDa and low-molecular sodium hyaluronate with a molecular weight of 20w-40wDa. Further, sodium hyaluronate includes high-molecular sodium hyaluronate and low-molecular sodium hyaluronate in a mass ratio of (1-5):(2-10). By using sodium hyaluronate with different molecular weights, it is helpful to form a tighter supramolecular structure with the dendrobium extract, further improving the moisture retention.

[0053] For example, in different embodiments, the molecular weight of high molecular weight sodium hyaluronate may be 100wDa, 120wDa, 150wDa, 180wDa, or a range consisting of any two thereof; the molecular weight of low molecular weight sodium hyaluronate may be 20wDa, 25wDa, 300wDa, 35wDa, 40wDa, or a range consisting of any two thereof;

[0054] The mass ratio of high molecular sodium hyaluronate to low molecular sodium hyaluronate may be 1:2, 1:5, 1:8, 1:10, 1:1, 2:5, 3:2, 3:5, 3:8, 3:10, 5:2, 5:8 or a range consisting of any two of them.

[0055] The combination of Dendrobium extract and sodium hyaluronate can form a supramolecular structure with good skin feel and small molecular weight, and also has excellent moisturizing effects.

[0056] In a specific embodiment of the present invention, the Dendrobium Sodium Hyaluronate Extract further comprises an alcohol solvent and a preservative. Further, in the Dendrobium Sodium Hyaluronate Extract, the mass fraction of the alcohol solvent is 7% to 11%, and the preservative comprises 1,2-pentanediol and p-hydroxyacetophenone, with mass fractions of 4.0% and 0.3%, respectively.

[0057] For example, in different embodiments, the mass fraction of the alcohol solvent can be 7%, 8%, 9%, 10%, 11% or a range consisting of any two of them. The alcohol solvent may include but is not limited to glycerol. The type and amount of the preservative can be adjusted and selected according to actual needs.

[0058] In a specific embodiment of the present invention, the dendrobium extract includes a dendrobium extract and / or a dendrobium polysaccharide solution. Further, the preparation of the dendrobium extract includes: using water as an extraction solvent, the solid-liquid ratio is 1: (50-100), extracting the dendrobium stem at 55-70°C for 1-3 hours, decolorizing and deodorizing, and filtering. The preparation of the dendrobium polysaccharide solution includes: mixing dendrobium polysaccharide and water in proportion to obtain a dendrobium polysaccharide solution with a mass fraction of 0.01wt% to 0.04wt%.

[0059] In actual operation, in the preparation of the dendrobium extract, the solid-liquid ratio can be 1:50 (m / m), 1:60 (m / m), 1:70 (m / m), 1:80 (m / m), 1:90 (m / m), 1:100 (m / m) or a range consisting of any two thereof, the extraction temperature can be 55°C, 60°C, 65°C, 70°C or a range consisting of any two thereof, and the extraction time can be 1h, 2h, 3h or a range consisting of any two thereof. Before extraction, the dendrobium stem to be extracted is crushed. The dendrobium species used in the present invention can include Dendrobium officinale.

[0060] The decolorization and deodorization treatment can be carried out by adding activated carbon to the extracted liquid, wherein the amount of activated carbon added can be 0.2wt% of the mass of the liquid to be treated, and the treatment time can be 5 to 10 minutes.

[0061] For example, in different embodiments, the mass fraction of the Dendrobium polysaccharide solution can be 0.01wt%, 0.02wt%, 0.03wt%, 0.04wt% or a range consisting of any two of them.

[0062] In a specific embodiment of the present invention, the preparation of the Dendrobium sodium hyaluronate extract comprises: extracting the Dendrobium extract, sodium hyaluronate and hydrolyzed sodium hyaluronate at a gauge pressure of 0.05 to 0.13 MPa and 110 to 125° C. for 1 to 3 hours.

[0063] For example, in different embodiments, in the preparation of the sodium hyaluronate extract of Dendrobium officinale, the gauge pressure can be 0.05MPa, 0.06MPa, 0.08MPa, 0.1MPa, 0.12MPa, 0.13MPa or a range consisting of any two thereof, the temperature can be 110°C, 115°C, 120°C, 125°C or a range consisting of any two thereof, and the extraction time can be 1h, 2h, 3h or a range consisting of any two thereof.

[0064] The above treatment method is more helpful to utilize the hydrogen bonding effect of the dendrobium extract and sodium hyaluronate to form a supramolecular structure and achieve excellent moisturizing effect.

[0065] In a specific embodiment of the present invention, the Platycladus orientalis extract includes isoquercetin, afudamidin, aconitum biflavonoids, koreanolide and dextrorotatory quinic acid;

[0066] The mass ratio of isoquercetin, afusadrin, aconitum biflavonoids, scutellariae lactone and dextrorotatory quinic acid is 1:(2-2.7):(3.5-5):(2-2.6):(650-890).

[0067] For example, in different embodiments, the mass ratios of afudamidin, aconitum biflavonoids, koreanolide and dextrorotatory quinic acid to isoquercetin in the Platycladus orientalis extract can be exemplified as follows:

[0068] The mass ratio of afudamirin to isoquercetin can be 2, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7 or a range consisting of any two thereof;

[0069] The mass ratio of aconitum biflavonoids to isoquercetin can be 3.5, 3.8, 4, 4.2, 4.5, 4.8, 5 or a range consisting of any two thereof;

[0070] The mass ratio of koreanolide to isoquercetin may be 2, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6 or a range consisting of any two of them;

[0071] The mass ratio of dextrorotatory quinic acid to isoquercetin can be 650, 660, 680, 700, 750, 800, 850, 890 or a range consisting of any two of them.

[0072] In a specific embodiment of the present invention, in the Platycladus orientalis extract, the percentages of isoquercetin, afudamidin and aconitum biflavonoids in the total flavonoids are 0.30% to 1.00%, 0.60% to 1.90% and 3.50% to 3.90% respectively.

[0073] For example, in different embodiments, in the Platycladus orientalis extract, the percentage of isoquercetin in the total flavonoids can be 0.3%, 0.4%, 0.5%, 0.6%, 0.8%, 1% or a range consisting of any two thereof; the percentage of afusadrin in the total flavonoids can be 0.6%, 0.8%, 1%, 1.2%, 1.5%, 1.8%, 1.9% or a range consisting of any two thereof; the percentage of aconitum bisflavonoids in the total flavonoids can be 3.5%, 3.6%, 3.7%, 3.8%, 3.9% or a range consisting of any two thereof.

[0074] The total flavonoids refer to all flavonoid components in the Platycladus orientalis extract.

[0075] In a specific embodiment of the present invention, the Platycladus orientalis extract further comprises at least one of propylene glycol and butylene glycol. The propylene glycol may comprise 1,2-propylene glycol and / or 1,3-propylene glycol; and the butylene glycol may comprise at least one of 1,2-butylene glycol, 1,3-butylene glycol and 1,4-butylene glycol.

[0076] In a specific embodiment of the present invention, the Platycladus orientalis extract further comprises PEG-40 hydrogenated castor oil and / or disodium EDTA. Further, in the Platycladus orientalis extract, the mass fraction of PEG-40 hydrogenated castor oil is 0.2% to 0.6%, and the mass fraction of disodium EDTA is 0.1% to 0.2%.

[0077] For example, in different embodiments, in the Platycladus orientalis extract, the mass fraction of PEG-40 hydrogenated castor oil can be 0.2%, 0.3%, 0.4%, 0.5%, 0.6% or a range consisting of any two thereof, and the mass fraction of disodium EDTA can be 0.1%, 0.12%, 0.15%, 0.18%, 0.2% or a range consisting of any two thereof.

[0078] In a specific embodiment of the present invention, the preparation of the Platycladus orientalis extract comprises:

[0079] (a) using ethanol aqueous solution as the extraction solvent, with a solid-liquid ratio of 1:10 to 1:30, and extracting Platycladus orientalis leaves at 25 to 85°C for 1 to 3 hours;

[0080] (b) adjusting the pH of the extract obtained by the extraction to 8.3-9.5, stirring the extract, filtering the extract, and then adjusting the pH to 7.0±0.5.

[0081] Sodium hydroxide and / or citric acid can be used to adjust the pH. The specific addition form of sodium hydroxide and / or sodium citrate is not limited, such as aqueous solution, the mass fraction of the aqueous solution can be 10%, but not limited thereto.

[0082] In a specific embodiment of the present invention, the preparation of the Platycladus orientalis extract further includes: concentrating the material adjusted to pH 7.0±0.5, and re-dissolving it with a propylene glycol aqueous solution or a butylene glycol aqueous solution. Further, adding PEG-40 hydrogenated castor oil and / or disodium EDTA to the re-dissolved material. Adding PEG-40 hydrogenated castor oil and / or disodium EDTA makes the PEG-40 hydrogenated castor oil and / or disodium EDTA in the material reach the target mass fraction.

[0083] In a specific embodiment of the present invention, the mass ratio of the sodium hyaluronate extract of Dendrobium officinale to the Platycladus orientalis extract is 1:(1-6).

[0084] For example, in different embodiments, the mass ratio of the Dendrobium sodium hyaluronate extract to the Platycladus orientalis extract can be 1:1, 1:2, 1:3, 1:4, 1:5, 1:6 or a range consisting of any two of them.

[0085] By controlling the mass ratio of the sodium hyaluronate extract of Dendrobium officinale and the Platycladus orientalis extract within the above range, the synergistic softening, oil-controlling and synergistic effects of the two can be further improved.

[0086] In a specific embodiment of the present invention, the oil-control shampoo further comprises at least one of a pH regulator, a fragrance and a preservative. Further, the oil-control shampoo further comprises the following components by weight: 0 to 0.5 parts of a pH regulator, 0 to 1.5 parts of a fragrance and 0.1 to 0.8 parts of a preservative.

[0087] In a specific embodiment of the present invention, the surfactant includes the following components by weight: 10 to 25 parts of a main surfactant and 0 to 10 parts of an auxiliary surfactant. Further, the main surfactant includes sodium laureth sulfate and / or ammonium laureth sulfate; the auxiliary surfactant includes at least one of lauryl hydroxysulfobetaine, cocamidopropyl betaine, sodium cocoamphoacetate and cocamide MEA.

[0088] For example, in different embodiments, among the surfactants, the amount of the main surfactant can be 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 22 parts, 25 parts or a range consisting of any two thereof by weight; the amount of the auxiliary surfactant can be 0 parts, 2 parts, 5 parts, 8 parts, 10 parts or a range consisting of any two thereof.

[0089] In a specific embodiment of the present invention, the cationic conditioning agent includes at least one of guar hydroxypropyltrimonium chloride, polyquaternium-10 and polyquaternium-39. Further, in the oil control shampoo, the mass fraction of the cationic conditioning agent is 0.02% to 0.35%.

[0090] For example, in different embodiments, the mass fraction of the cationic conditioning agent in the oil control shampoo can be 0.02%, 0.05%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35% or a range consisting of any two of them. The present invention can reduce the amount of cationic conditioning agent in the oil control shampoo by adjusting the types of components, and cooperate with other components to improve the problems of softness, increased oil production, dandruff, etc.

[0091] In a specific embodiment of the present invention, the chelating agent includes at least one of disodium EDTA, trisodium EDTA, tetrasodium EDTA and sodium glucoheptonate. The amount of the chelating agent can be 0.05 parts, 0.1 parts, 0.15 parts, 0.2 parts or a range consisting of any two of them.

[0092] In a specific embodiment of the present invention, the rheology modifier includes at least one of sodium chloride, trihydroxystearin, carbomer 2020, acrylic copolymer, trihydroxystearin, ammonium xylene sulfonate, polyethylene glycol-14M and silica. The amount of the rheology modifier can be 0.1 part, 0.2 part, 0.5 part, 0.8 part, 1 part or any two thereof.

[0093] For example, in different embodiments, the amount of water can be 50 parts, 55 parts, 60 parts, 65 parts, 70 parts, or a range consisting of any two of them.

[0094] In a specific embodiment of the present invention, the pH regulator includes at least one of citric acid, sodium citrate and sodium hydroxide. The amount of the pH regulator can be 0 part, 0.1 part, 0.2 part, 0.4 part, 0.5 part or a range consisting of any two of them.

[0095] In a specific embodiment of the present invention, the preservative includes at least one of phenoxyethanol, ethylhexylglycerin, chlorphenesin, methylchloroisothiazolinone, methylisothiazolinone and sodium benzoate. The amount of the preservative can be 0.1 part, 0.2 part, 0.5 part, 0.8 part or a range consisting of any two of them.

[0096] In actual operation, the type of flavor can be adjusted according to actual needs, and various flavors in the cosmetics field can be used, such as rosewood flavor, etc. The amount of flavor can be 0 part, 0.2 part, 0.5 part, 0.8 part, 1 part, 1.2 parts, 1.5 parts or a range consisting of any two of them.

[0097] Another aspect of the present invention provides a method for preparing any one of the above-mentioned oil-control shampoo, comprising the following steps: mixing the components in proportion.

[0098] In a specific embodiment of the present invention, the following steps are included:

[0099] (A) mixing water, a chelating agent and a cationic conditioning agent in proportion and dissolving them, then adding a surfactant, heating to 80-85° C. and stirring until dissolved;

[0100] (B) Cooling the material obtained in step (A) to below 45°C, adding the remaining materials and stirring evenly.

[0101] Among them, the remaining materials include hair conditioners, rheology regulators, pH regulators, fragrances and preservatives, if any, which are also added.

[0102] Embodiments 1 to 5

[0103] Examples 1 to 5 provide oil-control shampoos, respectively, and their raw materials and amounts are shown in Table 1.

[0104] Table 1 Formula of the oil control shampoo of Examples 1 to 5

[0105]

[0106] Note: The mass ratio of phenoxyethanol to ethylhexylglycerin is 9:1, and the mass ratio of methylchloroisothiazolinone to methylisothiazolinone is 3:1.

[0107] The preparation method of the oil-control shampoo of Examples 1 to 5 comprises the following steps:

[0108] (1) Stir the raw materials of phase A until they are completely dissolved;

[0109] (2) Add the raw materials of phase B to the materials of step (1) in sequence, heat to 80-85° C. and stir until completely dissolved;

[0110] (3) Cooling the material obtained in step (2) to below 45° C., then sequentially adding the raw materials of phase C and phase D, and stirring thoroughly;

[0111] (4) Cooling the material obtained in step (3) to below 38° C. and discharging the material after passing the inspection. The preparation method of the sodium hyaluronate extract of Dendrobium officinale in Examples 1 to 5 comprises the following steps:

[0112] (1) Weigh 20 g of Dendrobium officinale stem, crush it through an 80-mesh sieve, mix it with water at a solid-liquid ratio of 1:80 (m / m), stir and extract at 65° C. for 2 h, let it stand, filter it with 170-mesh gauze and F100 paperboard in turn, add 0.2 wt% of activated carbon by weight of the filtrate to decolorize it for 5 min, then filter it with F100 paperboard, and adjust the pH value of the decolorized solution to 4.8-5.2 with 20% citric acid aqueous solution or 10% sodium hydroxide aqueous solution to obtain Dendrobium officinale extract;

[0113] (2) The Dendrobium officinale extract and total sodium hyaluronate were mixed in a mass ratio of 85:1.5, and then extracted at a gauge pressure of 0.07 MPa and 115°C for 1 hour to obtain the Dendrobium officinale sodium hyaluronate extract; wherein the total sodium hyaluronate includes high molecular weight sodium hyaluronate (molecular weight 100w~180wDa), low molecular weight sodium hyaluronate (molecular weight 20w~40wDa) and hydrolyzed sodium hyaluronate (molecular weight <1wDa) in a mass ratio of 2:7:6.

[0114] The preparation method of the Platycladus orientalis extract in Examples 1 to 5 comprises the following steps:

[0115] (1) Crush the Platycladus orientalis leaves, take the material on a 10-mesh sieve, use a 50% by volume ethanol aqueous solution as an extraction solvent, add the extraction solvent at a solid-liquid ratio of 1:15 (m / V), and soak for 0.5 h; then extract at 85°C for 1 h, and coarsely filter the extracted material to obtain an extract.

[0116] (2) The extract obtained in step (1) is adjusted to a pH of 9.3 to 9.5, stirred for 0.5 h to remove impurities, and then finely filtered to control the turbidity to ≤ 3, and the fine filtrate is collected; the pH of the fine filtrate is adjusted to 7.0 ± 0.1.

[0117] (3) The material obtained in step (2) is concentrated until the amount of crude drug reaches ±5%, and a 20% by mass fraction of 1,3-propylene glycol aqueous solution is added according to 9 times the amount of crude drug for redissolution, mechanically stirred at room temperature for 30 minutes, and 0.5% PEG-40 hydrogenated castor oil (the mass fraction of PEG-40 hydrogenated castor oil in the whole solution is 0.5%) is added for solubilization; then 0.1% (the mass fraction of disodium EDTA in the product) of disodium EDTA is added for color protection, and a clear solution is obtained by filtering; and then sterilized at 85° C. for 40 minutes to obtain a Platycladus orientalis extract.

[0118] Example 6

[0119] This example refers to the oil-control shampoo and preparation method thereof of Example 1, with the only difference being that a different Platycladus orientalis extract is used.

[0120] The preparation method of the Platycladus orientalis extract of this embodiment comprises the following steps:

[0121] (1) Crush the Platycladus orientalis leaves, take the material on a 10-mesh sieve, use a 50% by volume ethanol aqueous solution as an extraction solvent, add the extraction solvent at a solid-liquid ratio of 1:15 (m / V), and soak for 0.5 h; then extract at 85°C for 1 h, and coarsely filter the extracted material to obtain an extract.

[0122] (2) The material obtained in step (1) is concentrated until the amount reaches ±5% of the crude drug amount, and a 20% by mass fraction of 1,3-propylene glycol aqueous solution is added according to 9 times the amount of the crude drug for redissolution, mechanically stirred at room temperature for 30 minutes, and 0.5% PEG-40 hydrogenated castor oil (the mass fraction of PEG-40 hydrogenated castor oil in the whole solution is 0.5%) is added for solubilization; then 0.1% (the mass fraction of disodium EDTA in the product) of disodium EDTA is added for color protection, and a clear solution is obtained by filtering; and then sterilized at 85° C. for 40 minutes to obtain a Platycladus orientalis extract.

[0123] Example 7

[0124] This example refers to the oil-control shampoo and preparation method thereof of Example 1, with the only difference being that a different Platycladus orientalis extract is used.

[0125] The preparation method of the Platycladus orientalis extract of this embodiment comprises the following steps:

[0126] (1) Crush Platycladus orientalis leaves into fine powder (under 30 mesh sieve, on 50 mesh sieve), add 50% by volume ethanol aqueous solution as extraction solvent at a solid-liquid ratio of 1:15 (m / V), and soak for 0.5 h; then extract at 85°C for 1 h, and coarsely filter the extracted material to obtain an extract.

[0127] (2) The extract obtained in step (1) is adjusted to a pH of 9.3 to 9.5, stirred for 0.5 h to remove impurities, and then finely filtered to control the turbidity to ≤ 3, and the fine filtrate is collected; the pH of the fine filtrate is adjusted to 7.0 ± 0.1.

[0128] (3) The material obtained in step (2) is concentrated until the amount of crude drug reaches ±5%, and a 20% by mass fraction of 1,3-propylene glycol aqueous solution is added according to 9 times the amount of crude drug for redissolution, mechanically stirred at room temperature for 30 minutes, and 0.5% PEG-40 hydrogenated castor oil (the mass fraction of PEG-40 hydrogenated castor oil in the whole solution is 0.5%) is added for solubilization; then 0.1% (the mass fraction of disodium EDTA in the product) of disodium EDTA is added for color protection, and a clear solution is obtained by filtering; and then sterilized at 85° C. for 40 minutes to obtain a Platycladus orientalis extract.

[0129] Example 8

[0130] This embodiment refers to the oil-control shampoo and preparation method thereof of Example 1, with the only difference being that different amounts of the Dendrobium hyaluronate sodium extract and Platycladus orientalis extract are used.

[0131] The dosages of the Dendrobium officinale sodium hyaluronate extract and the Platycladus orientalis extract in this embodiment are 7.5% and 7.5% respectively.

[0132] Example 9

[0133] This embodiment refers to the oil-control shampoo and preparation method thereof of Example 1, with the only difference being that different amounts of the Dendrobium hyaluronate sodium extract and Platycladus orientalis extract are used.

[0134] The dosages of the Dendrobium officinale sodium hyaluronate extract and the Platycladus orientalis extract in this embodiment are 2.2% and 12.8% respectively.

[0135] Example 10

[0136] This embodiment refers to the oil-control shampoo and preparation method thereof of Example 1, with the only difference being that different amounts of the Dendrobium hyaluronate sodium extract and Platycladus orientalis extract are used.

[0137] The dosages of the Dendrobium officinale sodium hyaluronate extract and the Platycladus orientalis extract in this embodiment are 9% and 6% respectively.

[0138] Embodiment 11

[0139] This embodiment refers to the oil-control shampoo and preparation method thereof of Example 1, with the only difference being that different amounts of the Dendrobium hyaluronate sodium extract and Platycladus orientalis extract are used.

[0140] The dosages of the Dendrobium officinale sodium hyaluronate extract and the Platycladus orientalis extract in this embodiment are 1.5% and 13.5% respectively.

[0141] Example 12

[0142] This embodiment refers to the oil-control shampoo and preparation method thereof of Example 1, with the only difference being that in the Dendrobium sodium hyaluronate extract used, the mass ratio of the Dendrobium officinale extract and the total sodium hyaluronate is different, and the mass ratios of high-molecular sodium hyaluronate (molecular weight 100w~180wDa), low-molecular sodium hyaluronate (molecular weight 20w~40wDa) and hydrolyzed sodium hyaluronate (molecular weight <1wDa) are different.

[0143] In this embodiment, the mass ratio of Dendrobium officinale extract to total sodium hyaluronate is 25:1, and the mass ratio of high molecular sodium hyaluronate (molecular weight 100w~180wDa), low molecular sodium hyaluronate (molecular weight 20w~40wDa) and hydrolyzed sodium hyaluronate (molecular weight <1wDa) is 1:10:12.

[0144] Embodiment 13

[0145] This embodiment refers to the oil-control shampoo and preparation method thereof of Example 1, with the only difference being that in the Dendrobium sodium hyaluronate extract used, the mass ratio of the Dendrobium officinale extract and the total sodium hyaluronate is different, and the mass ratios of high-molecular sodium hyaluronate (molecular weight 100w~180wDa), low-molecular sodium hyaluronate (molecular weight 20w~40wDa) and hydrolyzed sodium hyaluronate (molecular weight <1wDa) are different.

[0146] In this embodiment, the mass ratio of Dendrobium officinale extract to total sodium hyaluronate is 50:0.1, and the mass ratio of high molecular sodium hyaluronate (molecular weight 100w~180wDa), low molecular sodium hyaluronate (molecular weight 20w~40wDa) and hydrolyzed sodium hyaluronate (molecular weight <1wDa) is 5:2:5.

[0147] Comparative Examples 1 to 6

[0148] Comparative Examples 1 to 6 refer to the shampoo and preparation method of Example 1, except that the raw materials and amounts are different. The raw materials and amounts of Comparative Examples 1 to 6 are shown in Table 2.

[0149] Table 2 Formulas of shampoos of Comparative Examples 1 to 6

[0150]

[0151] Experimental Example 1

[0152] The composition of the Platycladus orientalis extract used in Example 1 and Example 6 was analyzed. Since the Platycladus orientalis extract used in Example 1 and Example 6 is a liquid, and contains additional components such as a reconstitution solvent, PEG-40, and disodium EDTA, in order to reduce interference with component detection, the material obtained in step (2) of the preparation of the Platycladus orientalis extract in Example 1 and the material obtained in step (1) of the preparation of the Platycladus orientalis extract in Example 6 were processed into solid powders, and then the full component analysis was performed and the percentage of flavonoids in the total flavonoids was detected to reduce interference.

[0153] The method for processing into solid powder includes: concentrating the corresponding material at 60±5℃ under negative pressure to remove ethanol until the solid content of the concentrate reaches 8% to 10%; placing the concentrate in a spray dryer, controlling the inlet temperature to 140℃, drying for about 1h, collecting the powder, and conducting subsequent testing. Among them, the full component analysis is identified using HPLC-MS / MS (high performance liquid chromatography mass spectrometry). The test results are shown in Tables 3 and 4.

[0154] Table 3 Full component analysis results of Example 1 and Example 6 (mg / g)

[0155] serial number Isoquercetin Afudamicin Aconitum biflavonoids rosin lactone D-quinic acid Example 1 0.850 1.925 3.981 1.834 560.61 Example 6 0.321 1.203 3.320 0.120 709.44

[0156] Table 4 The percentage of flavonoids in Example 1 and Example 6 to total flavonoids

[0157] serial number Isoquercetin Afudamicin Aconitum biflavonoids Example 1 0.80％ 1.82％ 3.76％ Example 6 0.35％ 1.31％ 3.60％

[0158] For the convenience of testing, the solid powder corresponding to Example 1 prepared by the above method (i.e., the solid powder sample of full component analysis) was subjected to 5α-reductase inhibition test, Malassezia inhibition test and zebrafish embryo blood circulation promotion efficacy test. The test methods and results are as follows.

[0159] 5α-Reductase Inhibition Assay

[0160] (1) Test drug: solid powder corresponding to Example 1 prepared by the above method.

[0161] (2) Positive control drug: finasteride, a product of Merck Sharp & Dohme Limited; Properties: film-coated tablets, white after removal of the coating; Specification: 5 mg / tablet; Batch number: 0022050. Storage conditions: light-shielded, airtight, and stored at room temperature.

[0162] (3) Drug preparation: The test drug was tested at 10 concentrations: 35 mg / mL (solute is the solid powder of Example 1, solvent is 20% ethanol aqueous solution) was used as the initial concentration, and 9 2.5-fold gradient dilutions were made using 20% ​​ethanol aqueous solution; the positive control finasteride was diluted 5 times by 2 using anhydrous ethanol.

[0163] (4) Reagents: reduced coenzyme II (NADPH), product of Sigma, catalog number N7505, batch number: 041939; testosterone (T), product of Merck, catalog number T-037, batch number: FE03112002; Tris buffer: Shanghai Yuanye Biotechnology Co., Ltd., batch number J17HR10516A.

[0164] (5) Testing instrument: ZDN microplate reader, product of BioTek.

[0165] Test method:

[0166] Mouse liver was dissected and homogenized by adding Tris buffer at a ratio of 1:5 at 0°C, centrifuged at 4°C and 10,000 g for 15 minutes, and the supernatant was centrifuged at 0°C and 55,000 g for 1 hour and then taken out and placed at 4°C for later use. Reagents and samples were added according to the reaction system. Example 1 Solid powder and finasteride samples of each dilution were added 4 times. After incubation at 37°C for 60 minutes, the decrease in absorbance at 340 nm was measured.

[0167]

[0168] The 5α-reductase reaction system is shown in Table 5:

[0169] Table 5 Reagent dosage of reaction system (μL)

[0170] Substance name Addition volume μL Final concentration μmol / L 5α-Reductase Solution 10 - T 5 25 NADPH 10 100 Drugs to be tested 5 PBS 220

[0171] Test results:

[0172] Inhibition rate and IC of 5α-reductase in different concentration gradients of finasteride and tested drugs 50 The results are shown in Table 6.

[0173] Table 6 Inhibition rate and IC of 5α-reductase of the tested drugs and finasteride in Example 1 50

[0174]

[0175] From the above results, it can be seen that the Platycladus orientalis extract of Example 1 has an inhibitory effect on the activity of 5α-reductase, IC 50 The IC value of Platycladus orientalis extract in the reaction system was 3.78 mg / mL.50 The concentration of the crude drug is 0.076 mg / mL, which is equivalent to 0.72 mg / mL. In summary, the solid powder of Example 1 of the Platycladus orientalis extract of the present invention has a significant 5α-reductase inhibitory effect at a low concentration.

[0176] Malassezia antibacterial test

[0177] Test Materials:

[0178] (1) Experimental instruments

[0179] The main instruments used in this experiment are shown in Table 7.

[0180] Table 7 Main instruments of the experiment

[0181] Instrument Name model Manufacturer ELISA reader infinite M200 PRO Tecan Centrifuge Centrifuge 5430R Eppendorf Ultra clean workbench / /

[0182] (2) Experimental reagents

[0183] The main reagents used in this experiment are shown in Table 8.

[0184] Table 8 Main reagents for the experiment

[0185] Reagent name Manufacturer Malt extract medium Obostar Sterile PBS Gibco

[0186] (3) Sample information table

[0187] The sample information of this experiment is shown in Table 9.

[0188] Table 9 Experimental sample information

[0189]

[0190] Note: The solid powder of Example 7 is prepared using the material obtained in step (2) during the preparation of Platycladus orientalis extract in Example 7 as raw material.

[0191] Test method:

[0192] Cultivation of Malassezia

[0193] Shake the culture medium and Malassezia until there is no sediment at the bottom. Use a sterile syringe to transfer 200-800 μL of bacterial solution into the new culture medium and culture it in a biochemical incubator at 38°C. After 2-3 days of culture, subculture.

[0194] Micro-broth method to test the antibacterial activity of samples

[0195] 1. Prepare fresh culture medium

[0196] Transfer the sterile malt extract medium into a sterile 50 mL centrifuge tube. Centrifuge the sterile malt extract medium for 10 min at 25°C and 3500 rpm. Take the supernatant and place it in another sterile 50 mL centrifuge tube for later use.

[0197] Each sample was diluted with fresh culture medium to 50 mg / mL, 40 mg / mL, 30 mg / mL, 20 mg / mL, 10 mg / mL, and 5 mg / mL.

[0198] 2. Extraction of Malassezia

[0199] Gently shake the culture medium and Malassezia, transfer to a sterile 50 mL centrifuge tube, centrifuge at 25°C and 1000 rpm for 30 seconds, transfer the supernatant to a sterile 50 mL centrifuge tube, and centrifuge at 25°C and 3500 rpm for 10 minutes.

[0200] 3. Determination of bacterial solution concentration

[0201] Turn on the microplate reader and set the wavelength to 600nm. Take 400μL of the bacterial solution and place it in a 1.5mL sterile centrifuge tube. Add 1mL PBS and take 200μL of the bacterial solution from the 1.5mL centrifuge tube containing 400μL of bacterial solution and place it in a regular 96-well plate. Measure the OD of the bacterial solution at 600nm. 600 If OD 600 When the OD value is > 1, dilute with sterile PBS. (You can explore from 2 times, 4 times, 6 times, and 8 times) When the OD value is equal to 1, you can proceed to the next step of the experiment.

[0202] 4. Dilution of bacterial solution

[0203] Calculate the volume of bacterial suspension required. 600 =1) Dilute 160 times with fresh culture medium.

[0204] 5. Paving

[0205] In a sterile 96-well culture plate, add 100 μL of diluted bacterial suspension to each test well, then add 100 μL of samples of different concentrations, 100 μL of samples of different concentrations + 100 μL of malt medium as the control group, 200 μL of malt medium without bacteria as the blank control, 100 μL of diluted bacterial suspension + 100 μL of malt medium as the negative control, 100 μL of diluted bacterial suspension + 100 μL of 4 μg / mL ketoconazole as the positive control, and make 3 duplicate wells for each.

[0206] A sterile 96-well culture plate was placed in a 38°C incubator. After 72 hours of incubation, the absorbance was measured at 600 nm.

[0207] 6. Malassezia inhibition rate

[0208]

[0209]

[0210] Test results: See Table 10.

[0211] Table 10 Test results

[0212]

[0213] From the above results, it can be seen that the solid powder samples of Examples 6 and 7 have no Malassezia inhibitory effect at a concentration below 50 mg / mL, and the solid powder sample of Example 1 has a Malassezia inhibitory effect at a concentration above 10 mg / mL. In summary, the Platycladus orientalis extract of Example 1 has a significant Malassezia inhibitory effect at a low concentration.

[0214] Zebrafish embryos promote blood circulation

[0215] Test method:

[0216] Pick healthy 3-day-post-fertilization (DPF) zebrafish embryos.

[0217] 1. Test grouping:

[0218] The test requires setting up a blank control group (fish embryo culture medium / solvent solution), a positive control group (caffeine solution) and a test substance group (solid powder sample corresponding to Example 1).

[0219] 2. Blank control group setting:

[0220] 40 fish embryos were randomly selected, transferred to a 6 cm culture dish, and 8 mL of fish embryo culture medium was added.

[0221] 3. Positive control group setting:

[0222] 40 fish embryos were randomly selected and transferred to a 6 cm culture dish, and 8 mL of 0.05 g / L caffeine solution was added (the working solution was 0.05 g / L caffeine solution prepared with fish embryo culture medium).

[0223] 4. Handling of test substances:

[0224] 40 fish embryos were randomly selected and transferred to a 6 cm culture dish, and 8 mL of the test substance solution was added (the test substance was directly dissolved in the fish embryo culture medium to prepare the test solution). The dish was placed in a 28±1°C incubator and cultured for 2±0.5 h.

[0225] 5. Microscopic analysis of samples:

[0226] Use tricaine working solution (weigh 200 mg tricaine (analytical grade) and dissolve it in 48.95 mL water to prepare the storage solution. Refrigerate. It is valid within 30 days. The working solution is diluted to 0.04% with fish embryo culture medium and freshly prepared before use) to anesthetize the fish embryo for 2 minutes, and the dorsal aorta of the fish embryo is photographed for 20 seconds under a microscope.

[0227] 6. Data and result calculation:

[0228] Use software such as DanioScope to measure the relative blood flow velocity in the dorsal aorta of each fish embryo and take the average value.

[0229] Calculation results:

[0230] Calculate the blood circulation promotion rate: promotion rate = (TC) / C×100%;

[0231] In the above formula:

[0232] T—the average relative velocity of blood flow in the dorsal aorta of fish embryos in the test substance treatment group;

[0233] C—The average relative velocity of blood flow in the dorsal aorta of fish embryos in the blank control group.

[0234] A two-tailed T test was performed on the relative blood flow velocity of the dorsal aorta of fish embryos in the test substance treatment group and the relative blood flow of the dorsal aorta of the blank control group to obtain the p value.

[0235] Test results: The test results are shown in Table 11.

[0236] Table 11 Test results

[0237]

[0238] From the above results, it can be seen that the solid powder corresponding to Example 1 of the present invention has a significant effect of promoting blood circulation at low concentrations, which to a certain extent proves that the Platycladus orientalis extract of Example 1 has a nourishing and anti-hair loss effect.

[0239] Experimental Example 2

[0240] During the preparation of shampoo products, if the raw materials are still not dissolved after stirring for more than 2 hours, it means that this formula cannot be converted into a finished product and is not feasible. After the production is completed, observe the offline status and then test its performance. Observe whether the offline products have unstable phenomena such as stratification, precipitation, too thin or too thick. If not, the status is good; if the product is too thin or too thick, without stratification or precipitation, the status is average; if the product has stratification or precipitation, the status is poor. Then take an appropriate amount of shampoo for shampooing test to examine its cleaning power and the feeling of use during shampooing. The cleaning power is judged as strong, strong, average, weak, and weak. The feeling of use is judged as good, good, average, poor, and poor.

[0241] The preparation feasibility and shampoo test results of the shampoo products of different embodiments and comparative examples are shown in Table 12.

[0242] Table 12 Preparation feasibility and shampoo test results of different shampoo products

[0243]

[0244]

[0245] During the experiment, it was found that in Comparative Example 2, the formula contained less water, and the sodium laureth sulfate was not completely dissolved in 2 hours, so the process was not feasible. In Comparative Example 5, the high content of guar gum hydroxypropyltrimethylammonium chloride affected the dissolution of sodium laureth sulfate, and it was not completely dissolved in 2 hours, so the process was not feasible. In Comparative Example 6, the product was too dilute and inconvenient for normal use.

[0246] Experimental Example 3

[0247] 1. Comparison of combing effects

[0248] The dry and wet combing performance tests were conducted on Examples 1 to 2, Comparative Examples 1 and 3. The test method included: after washing the hair bundle, squeezing out excess water, taking an appropriate amount (0.2 mL of the test sample per gram of hair) of the sample and applying it evenly from the middle to the ends of the hair, gently massaging for 3 minutes, and rinsing with warm water. The dry combing work and wet combing work of the hair bundle before and after using the sample were measured. The test results are shown in Tables 13 to 13.

[0249] Table 13 Dry combing test results of different shampoo products

[0250]

[0251] Table 14 Wet combing test results of different shampoo products

[0252]

[0253] From the above test results, it can be seen that the dry and wet combing properties of the shampoos of Examples 1 and 2 are good, and Example 1 has the best effect. By comparing Example 1 with Comparative Example 1 and Comparative Example 3, it can be seen that Example 1 of the present invention produces a supramolecular structure by adding the sodium hyaluronate extract of Dendrobium officinale and guar hydroxypropyltrimethylammonium chloride, so that the sodium hyaluronate extract of Dendrobium officinale can be better attached to the hair with guar hydroxypropyltrimethylammonium chloride, thereby obtaining better dry and wet combing properties. Example 1 adds 0.15% less guar hydroxypropyltrimethylammonium chloride than Example 2, but the effect of dry and wet combing properties of Example 1 is better than that of Example 2. It can be seen that Example 1 reduces the use content of guar hydroxypropyltrimethylammonium chloride by adding the sodium hyaluronate extract of Dendrobium officinale. The above results prove that the sodium hyaluronate extract of Dendrobium officinale and the cationic conditioner in Example 1 synergistically improve the dry and wet combing properties of the shampoo.

[0254] 2. Comparison of scalp moisturizing effects

[0255] 90 volunteers (18-55 years old, both male and female) were selected to evaluate the moisturizing effect of the product by testing the scalp moisture content before and after 2 weeks of use. One sample was tested on each volunteer's head, and a total of 9 samples including Examples 1-5, Comparative Examples 1, 3, 5, and 6 were selected for the scalp moisture content test. The technicians used the test samples to wash the volunteers' hair, dried their hair with a hair dryer in the same way, and waited for 45 minutes in a constant temperature and humidity environment ((22±1)℃, (50±5)%), and then measured using a Corneometer to evaluate the moisturizing effect of the samples.

[0256] During the 2-week test period, the tester used the test sample once every 2 days for 2 consecutive weeks. Before use and after 2 weeks of use, the scalp was tested for skin moisture content, and the hair was not washed within 24 hours before the test. The test results are shown in Table 15.

[0257] Table 15 Scalp moisture content test results (n=10)

[0258]

[0259] It can be seen from the above test results that under the same test time, the scalp moisture content after using the shampoo of Examples 1 to 5 is significantly increased compared with Comparative Examples 1, 3, 5, and 6. Among Examples 1 to 5, Example 1 has the best effect.

[0260] 3. Comparison of long-term effects of scalp oil control

[0261] 30 volunteers (18-55 years old, both male and female) were selected for scalp oil test. The volunteers did not wash their hair the night before the test. The test time points were before sample application, immediately after sample application, and 8 hours after sample application. The test site was the temporal part of the top of the head. The test sample was used to wash the hair. The oil content was tested three times at the test site for analysis. When washing the hair, the same person used the same method to wash the volunteers' hair and used a hair dryer with medium-speed hot air until the volunteers' hair was dry. The volunteers went to the constant temperature and humidity chamber (((22±1)℃, (50±5)%)) 30 minutes before the test time and sat quietly waiting for the measurement. The test results are shown in Table 16.

[0262] Table 16 Scalp oil content at different time periods after using the sample (ug / cm 2 , n = 10)

[0263] Time Example 1 Comparative Example 1 Comparative Example 3 Before using 112 118 100 Immediately after using the sample 24 48 31 8 hours after use 62 82 65 The mean difference between before and after the sample 88 70 69 The mean difference between before and 8 hours after using the sample 50 36 35

[0264] From the above test results, it can be seen that Example 1 has a better long-term oil control effect than Comparative Examples 1 and 3. Compared with the formulas of Comparative Examples 1 and 3, the Dendrobium Sodium Hyaluronate Extract and Guar Gum Hydroxypropyltrimethylammonium Chloride in Example 1 produce a supramolecular structure, so that the effective ingredients of the Platycladus orientalis extract are slowly released to exert the oil control effect, and a better long-term oil control effect has been achieved.

[0265] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. Oil-control shampoo, characterized in that: It includes the following components by weight: 10-35 parts of surfactant, 0.8-15 parts of hair conditioning agent, 0.02-0.35 parts of cationic conditioning agent, 0.05-0.2 parts of chelating agent, 0.1-1 parts of rheology modifier and 50-70 parts of water; The hair conditioning agent comprises 0.3-5 parts of sodium hyaluronate extract of dendrobium and 0.5-10 parts of orientalis extract by weight.

2. The oil-control shampoo according to claim 1, characterized in that: The Dendrobium sodium hyaluronate extract comprises Dendrobium stem extract, sodium hyaluronate and hydrolyzed sodium hyaluronate; Preferably, the mass ratio of the sodium hyaluronate to the hydrolyzed sodium hyaluronate and to the Dendrobium stem extract is (0.1-1):(25-50); Preferably, the mass ratio of the sodium hyaluronate to the hydrolyzed sodium hyaluronate is (3-15):(5-12).

3. The oil-control shampoo according to claim 1, characterized in that: The sodium hyaluronate includes high-molecular sodium hyaluronate with a molecular weight of 100w-180wDa and low-molecular sodium hyaluronate with a molecular weight of 20w-40wDa; Preferably, the sodium hyaluronate comprises high molecular sodium hyaluronate and low molecular sodium hyaluronate in a mass ratio of (1-5) : (2-10).

4. The oil-control shampoo according to claim 1, characterized in that: The Platycladus orientalis extract comprises isoquercetin, afudamidin, aconitum biflavonoids, koreanolide and dextrorotatory quinic acid; The mass ratio of the isoquercetin, the afusadrin, the aconitum biflavonoids, the koreanolide and the dextrorotatory quinic acid is 1:(2-2.7):(3.5-5):(2-2.6):(650-890); Preferably, in the Platycladus orientalis extract, the percentages of isoquercetin, afudamirin and aconitum biflavonoids in the total flavonoids are 0.30% to 1.00%, 0.60% to 1.90% and 3.50% to 3.90%, respectively.

5. The oil-control shampoo according to claim 1, characterized in that: The Platycladus orientalis extract further comprises at least one of propylene glycol and butylene glycol; Preferably, the Platycladus orientalis extract further comprises PEG-40 hydrogenated castor oil and / or disodium EDTA; Preferably, in the Platycladus orientalis extract, the mass fraction of the PEG-40 hydrogenated castor oil is 0.2% to 0.6%, and the mass fraction of the disodium EDTA is 0.1% to 0.2%.

6. The oil-control shampoo according to claim 1, characterized in that: The preparation of the Platycladus orientalis extract comprises: (a) using ethanol aqueous solution as the extraction solvent, with a solid-liquid ratio of 1:10 to 1:30, and extracting Platycladus orientalis leaves at 25 to 85°C for 1 to 3 hours; (b) adjusting the pH of the extract obtained by the extraction to 8.3-9.5, stirring and filtering, and then adjusting the pH to 7.0±0.5; Preferably, the method further comprises: concentrating the material whose pH is adjusted to 7.0±0.5, and re-dissolving the material with a propylene glycol aqueous solution or a butylene glycol aqueous solution; Preferably, PEG-40 hydrogenated castor oil and / or disodium EDTA are added to the re-dissolved material.

7. The oil-control shampoo according to claim 1, characterized in that: The mass ratio of the Dendrobium officinale sodium hyaluronate extract to the Platycladus orientalis extract is 1:(1-6); Preferably, in the oil-control shampoo, the mass fraction of the cationic conditioning agent is 0.02% to 0.35%.

8. The oil-control shampoo according to claim 1, characterized in that: The oil-control shampoo further comprises at least one of a pH regulator, a fragrance and a preservative; Preferably, the oil-control shampoo further comprises the following components in parts by weight: 0 to 0.5 parts of a pH adjuster, 0 to 1.5 parts of a fragrance, and 0.1 to 0.8 parts of a preservative.

9. The oil-control shampoo according to claim 1, characterized in that: The surfactant comprises the following components by weight: 10 to 25 parts of a main surfactant and 0 to 10 parts of an auxiliary surfactant; Preferably, the main surfactant includes sodium laureth sulfate and / or ammonium laureth sulfate; the auxiliary surfactant includes at least one of lauryl hydroxysulfobetaine, cocamidopropyl betaine, sodium cocoamphoacetate and cocamide MEA; Preferably, the cationic conditioning agent includes at least one of guar hydroxypropyltrimonium chloride, polyquaternium-10 and polyquaternium-39; Preferably, the chelating agent includes at least one of disodium EDTA, trisodium EDTA, tetrasodium EDTA and sodium glucoheptonate; The rheology modifier includes at least one of sodium chloride, trihydroxystearin, carbomer 2020, acrylic copolymer, trihydroxystearin, ammonium xylene sulfonate, polyethylene glycol-14M and silica.

10. The method for preparing the oil-control shampoo according to any one of claims 1 to 9, characterized in that: The method comprises the following steps: mixing the components in proportion; Preferably, including: (A) mixing water, a chelating agent and a cationic conditioning agent in proportion and dissolving them, then adding a surfactant, heating to 80-85° C. and stirring until dissolved; (B) Cooling the material obtained in step (A) to below 45°C, adding the remaining materials and stirring evenly.

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