Composition for treating Alzheimer's disease and preparation method thereof

Abstract

The invention provides a composition for treating Alzheimer's disease and a preparation method thereof, and relates to the field of traditional Chinese medicinal materials. The food comprises the following raw materials in parts by weight: 5-10 parts of kelp, 5-20 parts of concha haliotidis, 3-12 parts of polygala tenuifolia, 3-15 parts of poria cocos, 5-20 parts of salvia miltiorrhiza, 5-15 parts of fructus alpiniae oxyphyllae, 5-15 parts of fructus lycii, 1-5 parts of ginseng, 1-5 parts of rhizoma acori graminei, 2-3 parts of gastrodia elata, 5-10 parts of astragalus membranaceus, 1-2 parts of lactic acid bacteria and 5-10 parts of wall material auxiliary materials. In the composition, ginseng is used as a monarch drug, astragalus membranaceus is used as a ministerial drug, and concha haliotidis, polygala tenuifolia, poria cocos, salvia miltiorrhiza, fructus alpiniae oxyphyllae, fructus lycii, rhizoma acori graminei and gastrodia elata are used as assistants to cooperate with the monarch drug and the ministerial drug, so that multiple effects of reducing phlegm, softening hard mass, removing stasis, diminishing swelling, soothing the nerves, promoting intelligence, promoting blood circulation, removing blood stasis, improving brain circulation and the like are achieved; the memory and the learning ability of the patient are jointly improved.

Description

Technical Field

[0001] The present invention relates to the field of Chinese medicinal materials, and in particular to a composition for treating Alzheimer's disease and a preparation method thereof. Background Art

[0002] Alzheimer's disease is a serious neurodegenerative disease whose main pathological features include senile plaques formed by the deposition of β-amyloid protein, neurofibrillary tangles and neuronal loss. Its clinical manifestations include memory loss, cognitive impairment, abnormal behavior and personality changes.

[0003] As the global population ages, Alzheimer's disease has become a major challenge in the field of public health. At present, Western medicine drugs for treating Alzheimer's disease mainly focus on cholinesterase inhibitors and NMDA receptor antagonists, but their efficacy is limited, and long-term use may lead to drug resistance and side effects. From a holistic perspective, Chinese medicine believes that Alzheimer's disease is related to kidney deficiency and marrow loss, phlegm blocking the orifices, and blood stasis blocking the collaterals. Through the conditioning of Chinese medicine compound prescriptions, it is expected to achieve the purpose of treating both the symptoms and the root causes.

[0004] Patent 202311077918.1 discloses a traditional Chinese medicine composition for treating Alzheimer's disease, which uses 15-28 parts of kelp, 5-17 parts of selengensis, and 8-20 parts of beet as raw materials. The composition can reduce the activity of acetylcholinesterase and enhance the activity of acetyltransferase, and can effectively treat Alzheimer's disease.

[0005] Patent 201810762110.X discloses a Chinese medicine composition for preventing and treating Alzheimer's disease, which uses ginseng or ginseng total saponins; coptis chinensis or coptis chinensis total alkaloids; and chuanxiong or chuanxiong alcohol extract as raw materials, and can effectively prevent and treat Alzheimer's disease.

[0006] However, the current traditional Chinese medicine preparations for treating Alzheimer's disease all have disadvantages such as low drug utilization rate, which leads to unsatisfactory treatment effects and slow effects. Summary of the invention

[0007] The object of the present invention is to provide a composition for treating Alzheimer's disease, which has good efficacy on Alzheimer's disease and is easy to absorb.

[0008] Another object of the present invention is to provide a method for preparing a composition for treating Alzheimer's disease, wherein different raw materials are separated by multi-layer packaging, sustained release is achieved in vivo, and the effective ingredients of the raw materials are fully utilized.

[0009] The present invention solves the technical problem by adopting the following technical solutions.

[0010] On the one hand, an embodiment of the present invention provides a composition for treating Alzheimer's disease, comprising the following raw materials by weight: 5-10 parts of kelp, 5-20 parts of cassia bark, 3-12 parts of polygala, 3-15 parts of poria, 5-20 parts of salvia miltiorrhiza, 5-15 parts of alpinia oxyphylla, 5-15 parts of wolfberry, 1-5 parts of ginseng, 1-5 parts of calamus, 2-3 parts of gastrodia elata, 5-10 parts of astragalus, 1-2 parts of lactic acid bacteria and 5-10 parts of wall material auxiliary materials.

[0011] In some embodiments of the present invention, the wall material auxiliary materials include cyclodextrin, gelatin and starch.

[0012] In some embodiments of the present invention, the mass ratio of cyclodextrin, gelatin and starch is 0.1-0.2:1:1.

[0013] In some embodiments of the present invention, the following raw materials are included by weight: 5 parts of kelp, 10 parts of cassia bark, 8 parts of polygala, 8 parts of poria, 10 parts of salvia miltiorrhiza, 10 parts of alpinia oxyphylla, 8 parts of wolfberry, 5 parts of ginseng, 1 part of calamus, 2 parts of gastrodia elata, 5 parts of astragalus, 2 parts of lactic acid bacteria and 8 parts of wall material auxiliary materials.

[0014] In some embodiments of the present invention, the following raw materials are included by weight: 15 parts of kelp, 20 parts of cassia bark, 3 parts of polygala, 3 parts of poria, 20 parts of salvia miltiorrhiza, 5 parts of alpinia oxyphylla, 5 parts of wolfberry, 1 part of ginseng, 1 part of calamus, 2 parts of gastrodia elata, 10 parts of astragalus, 2 parts of lactic acid bacteria and 8 parts of wall material auxiliary materials.

[0015] On the other hand, an embodiment of the present invention provides a method for preparing a composition for treating Alzheimer's disease, comprising the following steps:

[0016] S1, mixing ginseng and astragalus, crushing, and sieving to obtain a first mixture;

[0017] S2, mixing Cassiae oleifera, Polygala tenuifolia, Poria cocos, Salvia miltiorrhiza, Alpinia oxyphylla, Lycium barbarum, Acorus calamus, and Gastrodia elata uniformly, crushing, and sieving to obtain a second mixture;

[0018] S3, mixing cyclodextrin and water, stirring evenly, adding the first mixture, performing ultrasonic vibration, stirring evenly, and spraying granulation to obtain first particles;

[0019] S4, mixing starch with water, stirring evenly, then adding the first particulate matter and the second mixture, stirring evenly, and spraying granulation to obtain second particulate matter;

[0020] S5, heating and stirring the gelatin until it becomes liquid, then adding the second particulate matter and lactic acid bacteria, stirring evenly, vacuum drying, grinding and crushing to obtain the composition.

[0021] In some embodiments of the present invention, in the steps S1 and S2, the particle size of the first mixture and the second mixture is 100-200 um.

[0022] In some embodiments of the present invention, in step S3, the frequency of ultrasonic oscillation is 20-30 KHz.

[0023] In some embodiments of the present invention, in step S3, the mass volume ratio of cyclodextrin to water is 1:(1-1.5).

[0024] In some embodiments of the present invention, in step S4, the mass volume ratio of starch to water is 1:(1-1.5).

[0025] Compared with the prior art, the embodiments of the present invention have at least the following advantages or beneficial effects:

[0026] The composition provided by the present invention uses ginseng as the main medicine, plays a major therapeutic role, replenishes qi and nourishes blood, calms the nerves and improves intelligence. Astragalus is used as the ministerial medicine, and ginseng is assisted to enhance the effect of replenishing qi and nourishing blood. With Semen Cassiae, Polygala, Poria, Salvia miltiorrhiza, Alpinia oxyphylla, Lycium barbarum, Acorus gramineus, and Gastrodia elata as adjuvants, the main medicine and ministerial medicine are coordinated to play multiple effects such as resolving phlegm and softening hard masses, dispersing nodules and reducing swelling, calming the nerves and improving intelligence, promoting blood circulation and removing blood stasis, and improving cerebral circulation. With lactic acid bacteria as the messenger, intestinal flora is regulated, immunity is enhanced, and the absorption and metabolism of traditional Chinese medicine are promoted, which is conducive to the overall efficacy. Secondly, Acorus gramineus, Alpinia oxyphylla, ginseng, etc. have the effect of calming the nerves and improving intelligence, and jointly improve the patient's memory and learning ability by regulating neurotransmitters and the endocrine system. Poria, etc. have anti-inflammatory and antioxidant effects, and jointly protect nerve cells from damage by reducing brain inflammation and oxidative stress damage.

[0027] The preparation method provided by the present invention wraps the main drug and the auxiliary drug together, then wraps the adjuvant drug on the outside, and finally wraps the serving drug, separates different medicinal materials with wall materials and auxiliary materials, and forms a multi-layer microcapsule. As a result, when taking the microcapsule, the gelatin of the outermost layer is broken and digested in the body, and lactic acid bacteria are released. The lactic acid bacteria regulate the stomach and intestines, provide a good intestinal environment for the subsequent release of Chinese medicinal materials, are beneficial to the absorption of effective ingredients of the Chinese medicinal materials, and improve the therapeutic effect. DETAILED DESCRIPTION

[0028] In order to make the purpose, technical scheme and advantages of the embodiments of the present invention clearer, the technical scheme in the embodiments of the present invention will be described clearly and completely below. If the specific conditions are not specified in the embodiments, they are carried out according to conventional conditions or conditions recommended by the manufacturer. If the manufacturer of the reagents or instruments used is not specified, they are all conventional products that can be purchased commercially.

[0029] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments may be combined with each other. The present invention will be described in detail below with reference to specific embodiments.

[0030] The embodiment of the present invention provides a composition for treating Alzheimer's disease, which includes the following raw materials in parts by weight: 5-10 parts of kelp, 5-20 parts of cassia bark, 3-12 parts of polygala, 3-15 parts of poria, 5-20 parts of salvia miltiorrhiza, 5-15 parts of alpinia oxyphylla, 5-15 parts of wolfberry, 1-5 parts of ginseng, 1-5 parts of calamus, 2-3 parts of gastrodia, 5-10 parts of astragalus, 1-2 parts of lactic acid bacteria and 5-10 parts of wall material auxiliary materials.

[0031] Ginseng, nature and flavor: sweet, slightly bitter, slightly warm. It enters the spleen, lung, and heart meridians. It greatly replenishes vital energy, nourishes the spleen and lungs, produces body fluids, calms the mind and improves intelligence. It is used for qi deficiency and impotence, weak pulse, spleen deficiency, sinking of middle qi, lung deficiency, wheezing and coughing, shortness of breath and fatigue, thirst due to loss of body fluids, thirst due to deficiency heat, insomnia and forgetfulness, palpitations, blood deficiency and sallow complexion, impotence and cold uterus, etc. Ginseng, as the main drug, is the core of the combination prescription and plays a leading therapeutic role. Its main effects are to replenish qi and blood, calm the mind and improve intelligence. Ginseng can replenish the body's vital energy, improve the condition of qi and blood deficiency, and at the same time help to calm the mind and improve intelligence and memory.

[0032] Astragalus, nature and flavor: sweet, warm. Return to the spleen and lung meridians. Invigorate qi and raise yang, consolidate the exterior and stop sweating, promote diuresis and reduce swelling, promote the production of body fluids and nourish blood, relieve stagnation and relieve arthralgia, support toxins and discharge pus, and promote the growth of ulcers and muscles. Used for qi deficiency and fatigue, poor appetite and loose stools, sinking of qi in the middle, chronic diarrhea and prolapse of the anus, blood in the stool and metrorrhagia, spontaneous sweating due to deficiency of the exterior, edema due to qi deficiency, internal heat and thirst, sallow complexion due to blood deficiency, hemiplegia, numbness and numbness of arthralgia, carbuncle is difficult to ulcerate, and ulcers are not ulcerated for a long time. As a ministerial drug, Astragalus mainly assists ginseng to enhance its effect of invigorating qi and nourishing blood. Astragalus also has the effects of invigorating qi and consolidating the exterior, promoting diuresis and reducing swelling, and supporting toxins and promoting the growth of ulcers, and complements ginseng to jointly enhance the overall qi-invigorating effect of the prescription. The addition of Astragalus makes the composition prescription of the present invention more comprehensive and powerful in terms of invigorating qi and nourishing blood.

[0033] Kelp: Nature and flavor: salty, cold. Enters the liver, stomach, and kidney meridians. It can dissolve phlegm and soften hard masses, and helps to dissipate phlegm and nodules in the body.

[0034] Semen Cassiae: Nature and flavor: salty, cold. Enters the liver meridian. Calms the liver and suppresses yang, clears the liver and improves eyesight, and has a relieving effect on symptoms such as excessive liver fire, dizziness, and vertigo.

[0035] Polygala: It calms the mind and improves intelligence, improves memory, and works together with ginseng on the nervous system.

[0036] Poria: It promotes diuresis and eliminates dampness, strengthens the spleen and calms the mind, helps regulate water balance in the body and improves sleep.

[0037] Salvia miltiorrhiza: It can promote blood circulation and remove blood stasis, and has a good therapeutic effect on symptoms such as poor blood circulation and blood stasis.

[0038] Alpinia oxyphylla: warms the spleen and stops diarrhea, warms the kidneys and consolidates essence and reduces urination, and also helps to calm the mind and improve intelligence.

[0039] Lycium barbarum: nourishes the liver and kidneys, improves eyesight and blood, and enhances immunity.

[0040] Acorus calamus: It can eliminate dampness, stimulate the appetite, open the orifices and eliminate phlegm. It has a therapeutic effect on symptoms such as phlegm and dampness obscuring the orifices.

[0041] Gastrodia elata: calms the liver and extinguishes wind, dispels wind and unclogs the meridians, and has an relieving effect on symptoms such as headache, dizziness, and limb numbness.

[0042] The above drugs are adjuvant drugs, which cooperate with the main drugs and the auxiliary drugs to jointly exert multiple functions such as resolving phlegm and softening hard masses, dispersing nodules and reducing swelling, calming the mind and improving intelligence, promoting blood circulation and removing blood stasis, and improving cerebral circulation, thereby improving the therapeutic effect of the combination.

[0043] Lactobacillus, as a drug adjuvant, regulates intestinal flora, enhances immunity, and promotes the absorption and metabolism of traditional Chinese medicine, thereby contributing to the overall efficacy of the drug. The addition of lactobacillus not only improves the utilization of traditional Chinese medicine, but also enhances the overall therapeutic effect of the composition.

[0044] In some embodiments of the present invention, the wall material auxiliary materials include cyclodextrin, gelatin and starch.

[0045] In some embodiments of the present invention, the mass ratio of cyclodextrin, gelatin and starch is 0.1-0.2:1:1.

[0046] In some embodiments of the present invention, the following raw materials are included by weight: 5 parts of kelp, 10 parts of cassia bark, 8 parts of polygala, 8 parts of poria, 10 parts of salvia miltiorrhiza, 10 parts of alpinia oxyphylla, 8 parts of wolfberry, 5 parts of ginseng, 1 part of calamus, 2 parts of gastrodia elata, 5 parts of astragalus, 2 parts of lactic acid bacteria and 8 parts of wall material auxiliary materials.

[0047] In some embodiments of the present invention, the following raw materials are included by weight: 15 parts of kelp, 20 parts of cassia bark, 3 parts of polygala, 3 parts of poria, 20 parts of salvia miltiorrhiza, 5 parts of alpinia oxyphylla, 5 parts of wolfberry, 1 part of ginseng, 1 part of calamus, 2 parts of gastrodia elata, 10 parts of astragalus, 2 parts of lactic acid bacteria and 8 parts of wall material auxiliary materials.

[0048] On the other hand, an embodiment of the present invention provides a method for preparing a composition for treating Alzheimer's disease, comprising the following steps:

[0049] S1, mixing ginseng and astragalus, crushing, sieving, selecting particles with a particle size of 100-200 um, and obtaining a first mixture;

[0050] S2, mixing Cassiae glabra, Polygala tenuifolia, Poria cocos, Salvia miltiorrhiza, Alpinia oxyphylla, Lycium barbarum, Acorus calamus, and Gastrodia elata uniformly, crushing, sieving, selecting particles with a particle size of 100-200 um, and obtaining a second mixture;

[0051] S3, mixing cyclodextrin and water in a mass volume ratio of 1:(1-1.5), stirring evenly, adding the first mixture, ultrasonically vibrating at a frequency of 20-30 kHz, stirring evenly, and spraying granulation to obtain first particles;

[0052] S4, mixing starch and water in a mass volume ratio of 1:(1-1.5), stirring evenly, then adding the first particulate matter and the second mixture, stirring evenly, and spray granulating to obtain the second particulate matter;

[0053] S5, heating and stirring the gelatin until it becomes liquid, then adding the second particulate matter and lactic acid bacteria, stirring evenly, vacuum drying, grinding and crushing to obtain the composition.

[0054] The composition prepared by the above method can be prepared into dosage forms such as pills, tablets or capsules.

[0055] The features and performance of the present invention are further described in detail below in conjunction with the embodiments.

[0056] Example 1

[0057] Prepare the raw materials according to the following ratio:

[0058] 5 parts of kelp, 10 parts of cassia bark, 8 parts of polygala, 8 parts of tuckahoe, 10 parts of salvia miltiorrhiza, 10 parts of alpinia oxyphylla, 8 parts of wolfberry, 5 parts of ginseng, 1 part of calamus, 2 parts of gastrodia elata, 5 parts of astragalus, 2 parts of lactic acid bacteria, 0.4 parts of cyclodextrin, 3.8 parts of gelatin, and 3.8 parts of starch.

[0059] The composition of this embodiment was prepared as follows:

[0060] S1, mixing ginseng and astragalus, crushing, sieving, selecting particles with a particle size of 100-200 um, and obtaining a first mixture;

[0061] S2, mixing Cassiae glabra, Polygala tenuifolia, Poria cocos, Salvia miltiorrhiza, Alpinia oxyphylla, Lycium barbarum, Acorus calamus, and Gastrodia elata uniformly, crushing, sieving, selecting particles with a particle size of 100-200 um, and obtaining a second mixture;

[0062] S3, mixing cyclodextrin and water at a mass volume ratio of 1:1, stirring evenly, adding the first mixture, ultrasonically vibrating at a frequency of 30 kHz, stirring evenly, and spraying granulation to obtain first particles;

[0063] S4, mixing starch with water, stirring evenly, then adding the first particulate matter and the second mixture, stirring evenly, and spraying granulation to obtain second particulate matter;

[0064] S5, heating the gelatin to 40° C., stirring until it becomes liquid, adding the second particulate matter and lactic acid bacteria, stirring evenly, vacuum drying, grinding and crushing to obtain the composition.

[0065] Example 2

[0066] Prepare the raw materials according to the following ratio:

[0067] 15 parts of kelp, 20 parts of cassia bark, 3 parts of polygala, 3 parts of tuckahoe, 20 parts of salvia miltiorrhiza, 5 parts of alpinia oxyphylla, 5 parts of wolfberry, 1 part of ginseng, 1 part of calamus, 2 parts of gastrodia elata, 10 parts of astragalus, 2 parts of lactic acid bacteria, 0.4 parts of cyclodextrin, 3.8 parts of gelatin, and 3.8 parts of starch.

[0068] The composition of this embodiment was prepared as follows:

[0069] S1, mixing ginseng and astragalus, crushing, sieving, selecting particles with a particle size of 100-200 um, and obtaining a first mixture;

[0070] S2, mixing Cassiae glabra, Polygala tenuifolia, Poria cocos, Salvia miltiorrhiza, Alpinia oxyphylla, Lycium barbarum, Acorus calamus, and Gastrodia elata uniformly, crushing, sieving, selecting particles with a particle size of 100-200 um, and obtaining a second mixture;

[0071] S3, mixing cyclodextrin and water at a mass volume ratio of 1:1, stirring evenly, adding the first mixture, ultrasonically vibrating at a frequency of 30 kHz, stirring evenly, and spraying granulation to obtain first particles;

[0072] S4, mixing starch and water at a mass volume ratio of 1:1, stirring evenly, then adding the first particulate matter and the second mixture, stirring evenly, and spraying granulation to obtain second particulate matter;

[0073] S5, heating the gelatin to 40° C., stirring until it becomes liquid, adding the second particulate matter and lactic acid bacteria, stirring evenly, vacuum drying, grinding and crushing to obtain the composition.

[0074] Example 3

[0075] Prepare the raw materials according to the following ratio:

[0076] 10 parts of kelp, 10 parts of cassia bark, 10 parts of polygala, 8 parts of tuckahoe, 10 parts of salvia miltiorrhiza, 8 parts of alpinia oxyphylla, 10 parts of wolfberry, 5 parts of ginseng, 5 parts of calamus, 2 parts of gastrodia elata, 5 parts of astragalus, 2 parts of lactic acid bacteria, 0.4 parts of cyclodextrin, 5 parts of gelatin, and 4.6 parts of starch.

[0077] The composition of this embodiment was prepared as follows:

[0078] S1, mixing ginseng and astragalus, crushing, sieving, selecting particles with a particle size of 100-200 um, and obtaining a first mixture;

[0079] S2, mixing Cassiae glabra, Polygala tenuifolia, Poria cocos, Salvia miltiorrhiza, Alpinia oxyphylla, Lycium barbarum, Acorus calamus, and Gastrodia elata uniformly, crushing, sieving, selecting particles with a particle size of 100-200 um, and obtaining a second mixture;

[0080] S3, mixing cyclodextrin and water at a mass volume ratio of 1:1.5, stirring evenly, adding the first mixture, ultrasonically vibrating at a frequency of 30 kHz, stirring evenly, and spraying granulation to obtain first particles;

[0081] S4, mixing starch and water at a mass volume ratio of 1:1.5, stirring evenly, then adding the first particulate matter and the second mixture, stirring evenly, and spray granulating to obtain the second particulate matter;

[0082] S5, heating the gelatin to 40° C., stirring until it becomes liquid, adding the second particulate matter and lactic acid bacteria, stirring evenly, vacuum drying, grinding and crushing to obtain the composition.

[0083] Example 4

[0084] Prepare the raw materials according to the following ratio:

[0085] 10 parts of kelp, 5 parts of cassia bark, 12 parts of polygala, 15 parts of tuckahoe, 10 parts of salvia miltiorrhiza, 8 parts of alpinia oxyphylla, 10 parts of wolfberry, 5 parts of ginseng, 5 parts of calamus, 2 parts of gastrodia elata, 10 parts of astragalus, 2 parts of lactic acid bacteria, 0.5 parts of cyclodextrin, 2 parts of gelatin, and 2.5 parts of starch.

[0086] The composition of this embodiment was prepared as follows:

[0087] S1, mixing ginseng and astragalus, crushing, sieving, selecting particles with a particle size of 100-200 um, and obtaining a first mixture;

[0088] S2, mixing Cassiae glabra, Polygala tenuifolia, Poria cocos, Salvia miltiorrhiza, Alpinia oxyphylla, Lycium barbarum, Acorus calamus, and Gastrodia elata uniformly, crushing, sieving, selecting particles with a particle size of 100-200 um, and obtaining a second mixture;

[0089] S3, mixing cyclodextrin and water at a mass volume ratio of 1:1.5, stirring evenly, adding the first mixture, ultrasonically vibrating at a frequency of 20 kHz, stirring evenly, and spraying granulation to obtain first particles;

[0090] S4, mixing starch and water at a mass volume ratio of 1:1.5, stirring evenly, then adding the first particulate matter and the second mixture, stirring evenly, and spray granulating to obtain the second particulate matter;

[0091] S5, heating the gelatin to 40° C., stirring until it becomes liquid, adding the second particulate matter and lactic acid bacteria, stirring evenly, vacuum drying, grinding and crushing to obtain the composition.

[0092] Typical Cases

[0093] Case 1: Male, 72 years old, suffering from mild Alzheimer's disease. He took the composition of Example 1 once a day, 5 g each time. After 3 months, his memory was significantly improved and his cognitive ability was improved.

[0094] Case 2: Female, 68 years old, suffering from moderate Alzheimer's disease. After taking the composition of Example 1, 5 g twice a day, for 6 months, her anxiety was relieved and her sleep quality was improved.

[0095] Case 3: Male, 75 years old, suffering from severe Alzheimer's disease. He took the composition of Example 2, 3 times a day, 5g each time. After 3 months, his memory improved. After 6 months of continued use, his personality cognition improved. After 9 months, his daily living ability improved and he no longer needed round-the-clock care.

[0096] Case 4: Female, 70 years old, suffering from mild Alzheimer's disease and constipation. Taking the composition of Example 2, 5g once a day, after 15 days, the constipation symptoms were relieved, after 1 month, the memory improved, after 3 months, the cognitive ability also improved, no special care was needed.

[0097] In summary, the composition provided by the embodiment of the present invention, which uses ginseng as the main medicine, plays a major therapeutic role, replenishes qi and nourishes blood, calms the nerves and improves intelligence. With Astragalus as the minister, ginseng is assisted to enhance the effect of replenishing qi and nourishing blood. With Semen Cassiae, Polygala, Poria, Salvia miltiorrhiza, Alpinia oxyphylla, Lycium barbarum, Acorus gramineus, Gastrodia elata as adjuvants, the main medicine and minister are coordinated to play multiple effects such as resolving phlegm and softening hard masses, dispersing nodules and reducing swelling, calming the nerves and improving intelligence, promoting blood circulation and removing blood stasis, and improving cerebral circulation. With lactic acid bacteria as the messenger, intestinal flora is regulated, immunity is enhanced, and the absorption and metabolism of traditional Chinese medicine are promoted, which is conducive to the overall efficacy. Secondly, Acorus gramineus, Alpinia oxyphylla, ginseng, etc. have the effect of calming the nerves and improving intelligence, and jointly improve the patient's memory and learning ability by regulating neurotransmitters and endocrine systems. Poria, etc. have anti-inflammatory and antioxidant effects, and jointly protect nerve cells from damage by reducing brain inflammation and oxidative stress damage.

[0098] After the patient takes the composition provided in this embodiment, the drug enters the body through the mouth, the outermost layer of gelatin begins to soften, and is decomposed under the action of digestive juice, releasing lactic acid bacteria, regulating intestinal flora, and improving the intestinal environment; then, under the action of digestive juice, starch and cyclodextrin are gradually decomposed, and Chinese medicinal materials are released, and under the action of digestive juice, their effective ingredients enter the blood and produce medicinal effects.

[0099] The embodiments described above are part of the embodiments of the present invention, rather than all of the embodiments. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

Claims

1. A composition for treating Alzheimer's disease, characterized in that: The following raw materials are included by weight: 5-10 parts of kelp, 5-20 parts of cassia bark, 3-12 parts of polygala, 3-15 parts of poria, 5-20 parts of salvia miltiorrhiza, 5-15 parts of alpinia oxyphylla, 5-15 parts of wolfberry, 1-5 parts of ginseng, 1-5 parts of calamus, 2-3 parts of gastrodia elata, 5-10 parts of astragalus, 1-2 parts of lactic acid bacteria and 5-10 parts of wall material auxiliary materials.

2. The composition for treating Alzheimer's disease according to claim 1, characterized in that: The wall material auxiliary materials include cyclodextrin, gelatin and starch.

3. The composition for treating Alzheimer's disease according to claim 2, characterized in that: The mass ratio of the cyclodextrin, gelatin and starch is 0.1-0.2:1:

1.

4. The composition for treating Alzheimer's disease according to claim 1, characterized in that: The following raw materials are included by weight: 5 parts of kelp, 10 parts of cassia bark, 8 parts of polygala, 8 parts of tuckahoe, 10 parts of salvia miltiorrhiza, 10 parts of alpinia oxyphylla, 8 parts of wolfberry, 5 parts of ginseng, 1 part of calamus, 2 parts of gastrodia elata, 5 parts of astragalus, 2 parts of lactic acid bacteria and 8 parts of wall material auxiliary materials.

5. The composition for treating Alzheimer's disease according to claim 1, characterized in that: The following raw materials are included by weight: 15 parts of kelp, 20 parts of cassia bark, 3 parts of polygala, 3 parts of poria, 20 parts of salvia miltiorrhiza, 5 parts of alpinia oxyphylla, 5 parts of wolfberry, 1 part of ginseng, 1 part of calamus, 2 parts of gastrodia elata, 10 parts of astragalus, 2 parts of lactic acid bacteria and 8 parts of wall material auxiliary materials.

6. A method for preparing a composition for treating Alzheimer's disease according to any one of claims 1 to 5, characterized in that: The following steps are involved: S1, mixing ginseng and astragalus, crushing, and sieving to obtain a first mixture; S2, mixing Cassiae oleifera, Polygala tenuifolia, Poria cocos, Salvia miltiorrhiza, Alpinia oxyphylla, Lycium barbarum, Acorus calamus, and Gastrodia elata uniformly, crushing, and sieving to obtain a second mixture; S3, mixing cyclodextrin and water, stirring evenly, adding the first mixture, performing ultrasonic vibration, stirring evenly, and spraying granulation to obtain first particles; S4, mixing starch with water, stirring evenly, then adding the first particulate matter and the second mixture, stirring evenly, and spraying granulation to obtain second particulate matter; S5, heating and stirring the gelatin until it becomes liquid, then adding the second particulate matter and lactic acid bacteria, stirring evenly, vacuum drying, grinding and crushing to obtain the composition.

7. The method for preparing the composition for treating Alzheimer's disease according to claim 6, characterized in that: In the steps S1 and S2, the particle sizes of the first mixture and the second mixture are 100-200 um.

8. The method for preparing the composition for treating Alzheimer's disease according to claim 6, characterized in that: In step S3, the frequency of ultrasonic oscillation is 20-30 KHz.

9. The method for preparing the composition for treating Alzheimer's disease according to claim 6, characterized in that: In step S3, the mass volume ratio of cyclodextrin to water is 1:(1-1.5).

10. The method for preparing the composition for treating Alzheimer's disease according to claim 6, characterized in that: In step S4, the mass volume ratio of starch to water is 1:(1-1.5).