Honeysuckle flower and pear syrup buccal tablet and preparation method thereof

Abstract

The invention discloses a honeysuckle flower and pear syrup buccal tablet and a preparation method thereof, and belongs to the field of food processing, and the honeysuckle flower and pear syrup buccal tablet comprises honeysuckle flowers, lily bulbs, radix ophiopogonis, bulbus fritillariae cirrhosae, pears, honey, fresh ginger, sorbitol, natural menthol, amomum tsao-ko, crystal sugar, water and auxiliary materials. The honeysuckle flower and pear syrup buccal tablet prepared by the invention becomes an ideal choice for conditioning the health of the respiratory system and enhancing the immunity of modern people by virtue of a unique formula, a scientific preparation process and a remarkable treatment effect of the honeysuckle flower and pear syrup buccal tablet. The traditional Chinese medicine composition has extremely high application value in adjuvant therapy of respiratory diseases such as cough and pharyngitis and maintenance of daily respiratory systems. According to the invention, natural herbaceous plants and fruit essence are carefully proportioned, so that an efficient, safe and excellent-taste scheme for relieving cough, moistening lung and treating pharyngitis is provided for consumers.

Description

Technical Field

[0001] The invention relates to the technical field of food processing, in particular to a honeysuckle pear paste lozenge and a preparation method thereof. Background Art

[0002] Pharyngitis is a non-specific inflammation of the pharynx. It is a general term for inflammation caused by various microorganisms infecting the pharynx. It can exist alone, coexist with rhinitis, tonsillitis and laryngitis, or be a prodromal symptom of certain diseases. It can be divided into acute pharyngitis and chronic pharyngitis. Acute pharyngitis is an acute inflammation of the pharyngeal mucosa and submucosal tissue. The pharyngeal lymphoid tissue is often involved. The inflammation can be localized in the early stage. As the disease progresses, it can often involve the entire pharyngeal cavity. It is more common in autumn and winter and winter and spring. The main manifestations are dryness, burning, pain, obvious pain when swallowing, congestion and swelling of the pharynx. Chronic pharyngitis can be divided into chronic simple pharyngitis, chronic hypertrophic pharyngitis and atrophic pharyngitis. Among them, chronic simple pharyngitis is more common. The lesions are mainly in the mucosal layer, manifested as chronic congestion of the pharyngeal mucosa, hyperplasia of the mucosal and submucosal connective tissue, hypertrophy of the mucous glands, hypersecretion, and increased mucus secretion. Patients often cough up sticky pharyngeal pharynx, or feel a foreign body sensation in the pharynx, which cannot be coughed up or swallowed. It is more common in adults, with a long course of disease, easy relapse, stubborn symptoms and difficulty in cure.

[0003] At present, for the treatment of pharyngitis, Western medicine mainly uses drug intervention and symptomatic treatment, and the main means of application are antibacterial and anti-inflammatory, etc. Commonly used drug preparations for the treatment of pharyngitis include compound dequalinium chloride, metronidazole gargle, chlorhexidine gargle, etc. Long-term use of one or more antibiotics in combination and alternation causes microorganisms to develop resistance to antibiotics and easily leads to respiratory flora disorders. Therefore, it often fails to achieve the ideal intervention effect, is difficult to use for a long time, and has poor patient tolerance.

[0004] Therefore, it is a technical problem that technicians in this field need to solve urgently to provide a lozenge of honeysuckle and pear paste that has a therapeutic effect on pharyngitis and can relieve cough and moisten the lungs using traditional Chinese medicine and a preparation method thereof. Summary of the invention

[0005] In view of this, the present invention provides a honeysuckle pear paste lozenge with cough relieving and lung moistening effects and a preparation method thereof.

[0006] In order to achieve the above object, the present invention adopts the following technical solution:

[0007] A honeysuckle and pear paste lozenge comprises the following raw materials in parts by weight: 5-15 parts of honeysuckle, 8-12 parts of lily, 5-10 parts of ophiopogon japonicus, 1-3 parts of fritillaria cirrhosa, 500-1500 parts of pears, 70-100 parts of honey, 6-10 parts of ginger, 2-5 parts of sorbitol, 10-20 parts of natural menthol, 2-5 parts of tsaoko, 1-10 parts of crystal sugar, 900-1300 parts of water and 500-1000 parts of auxiliary materials.

[0008] In the scheme of the present invention, honeysuckle, as a commonly used Chinese medicine, has the effects of clearing away heat and detoxicating, evacuating wind-heat, can effectively relieve cough symptoms, and reduce respiratory inflammation. Fritillaria cirrhosa, with its special effects of moistening the lungs and relieving cough, resolving phlegm and relieving asthma, goes deep into the lungs, relieves the discomfort caused by cough, and the combination of the two can significantly enhance the antitussive effect. Pear (especially the autumn pear and duck pear adopted by the present invention) is rich in multivitamins, has the effects of promoting body fluid and moistening dryness, clearing away heat and detoxicating, and has obvious relief effects on symptoms such as cough and dry throat. Lily and Ophiopogon japonicus can not only moisten the lungs, but also nourish the lungs, enhance the self-repair ability of the lungs, and promote respiratory health. In addition, menthol in the present invention has the characteristics of cooling and detoxicating, relieving throat pain, and can quickly relieve the symptoms such as sore throat, dryness, and foreign body sensation caused by pharyngitis, and alleviate the pain of patients. Amomum villosum is widely used in traditional medicine to treat sore throat, and the effective ingredients it contains can inhibit bacterial growth, reduce inflammatory reactions, and accelerate the recovery process of pharyngitis. Ginger has the effects of warming the middle and dispelling cold, promoting blood circulation, improving the body's overall resistance, and playing a positive role in preventing respiratory diseases such as colds and coughs. The raw materials of the present invention can achieve better effects of relieving coughs, moistening the lungs and treating pharyngitis through combination.

[0009] Furthermore, the auxiliary materials include maltodextrin, maltose, white sugar, mannitol and citric acid.

[0010] Furthermore, the mass ratio of the maltodextrin, maltose, white sugar, mannitol and citric acid is 100:15-25:80-120:50-150:2-10.

[0011] The beneficial effect of adopting the above further scheme is that auxiliary materials such as maltodextrin, maltose, white sugar, mannitol and citric acid not only provide the lozenges with a good taste, but also can regulate the acid-base balance in the body, promote metabolism, and enhance the body's immunity.

[0012] Furthermore, the pear is autumn pear or duck pear.

[0013] The present invention also provides a method for preparing the honeysuckle pear paste lozenge, comprising the following steps:

[0014] (1) Weigh the raw materials according to the above weight parts;

[0015] (2) Divide the water into two parts, cut the pear into small pieces of 1 cm square, then mix the small pieces with honeysuckle, lily, ophiopogon japonicus, Fritillaria cirrhosa, ginger and the first part of water, heat and boil for 20-30 minutes, filter with gauze to obtain a filtrate and a filter residue, squeeze the filter residue to obtain a filter residue liquid, combine the filtrate and the filter residue liquid, and then concentrate under reduced pressure to obtain a paste;

[0016] (3) mixing the paste obtained in step (2) with honey, sorbitol and natural menthol, adding the second portion of water, stirring evenly, and then sealing and storing for fermentation to obtain a fermented product;

[0017] (4) sterilizing the fermented product and then mixing it evenly with the auxiliary materials, and then pressing the product into tablets to obtain honeysuckle pear paste lozenges.

[0018] Furthermore, in step (2), the weight proportion of the first part of water is 800-1200 parts, and the remainder is the second part of water.

[0019] Furthermore, the relative density of the paste obtained by the reduced pressure concentration in step (2) at 50°C is 1.3-1.4 g / cm 3 .

[0020] Furthermore, in step (3), the stirring rate is 100-150 r / min, and the stirring time is 30-50 min;

[0021] Furthermore, in step (3), the fermentation temperature is 30-40° C. and the fermentation time is 3-5 days.

[0022] Furthermore, the sterilization in step (4) is pasteurization;

[0023] The tableting pressure is 1-5 kg / cm 2 , the tableting time is 10-30s.

[0024] Furthermore, the lozenge is a cylindrical lozenge with a thickness of 3 mm and a diameter of 1.5 cm.

[0025] The beneficial effects of the present invention are:

[0026] All ingredients of the present invention are natural plant and fruit extracts, do not contain any chemical additives and preservatives, and ensure the safety and health of the product. Through reduced pressure concentration, sealed fermentation and pasteurization, the sanitary quality and retention of nutrients of the product are ensured, making it safer and more reliable. The lozenge of the present invention combines the sweetness of pears with the sweetness of honey, and is supplemented with the cool taste of menthol, so that the product of the present invention not only has a significant therapeutic effect, but also has a good taste experience, and is suitable for people of all ages to take.

[0027] The honeysuckle pear paste lozenge prepared by the present invention has become an ideal choice for modern people to regulate respiratory health and enhance immunity with its unique formula, scientific preparation process and remarkable therapeutic effect. It has extremely high application value for auxiliary treatment of respiratory diseases such as cough and pharyngitis, as well as for daily maintenance of the respiratory system. The present invention provides consumers with an efficient, safe and excellent-tasting solution for relieving cough and moistening the lungs and treating pharyngitis through careful proportioning of natural herbal plants and fruit essences. DETAILED DESCRIPTION

[0028] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0029] In the embodiments of the present invention, the auxiliary materials are obtained by mixing maltodextrin, maltose, white sugar, mannitol and citric acid in a mass ratio of 100:20:100:80:5.

[0030] Example 1

[0031] A preparation method of honeysuckle pear paste lozenges:

[0032] (1) Weigh 15 parts of honeysuckle, 8 parts of lily, 5 parts of ophiopogon, 3 parts of Fritillaria cirrhosa, 1500 parts of pear, 70 parts of honey, 6 parts of ginger, 5 parts of sorbitol, 10 parts of natural menthol, 5 parts of tsaoko, 1 part of crystal sugar, 900 parts of water, and 1000 parts of auxiliary materials;

[0033] (2) Divide the water into two parts, the weight of the first part of the water is 800 parts, and the rest is the second part of the water. Cut the autumn pear into small pieces of 1 cm square, and then mix it with honeysuckle, lily, ophiopogon, Fritillaria cirrhosa, ginger and the first part of the water, heat and boil for 30 minutes, filter with gauze to obtain a filtrate and a filter residue, and then squeeze the filter residue to obtain a filter residue liquid, combine the filtrate and the filter residue liquid, and then reduce the pressure and concentrate them to obtain a paste. The relative density of the paste at 50° C. is 1.37 g / cm 3 ;

[0034] (3) mixing the paste obtained in step (2) with honey, sorbitol and natural menthol, adding the second portion of water, stirring at 150 r / min for 30 min, and then sealing and storing at 40° C. for fermentation for 3 days to obtain a fermentation product;

[0035] (4) After the fermentation product is pasteurized, mix it evenly with the auxiliary materials and then heat it at 5 kg / cm 2 The tablets were compressed for 10 seconds to obtain honeysuckle pear paste lozenges.

[0036] Example 2

[0037] A preparation method of honeysuckle pear paste lozenges:

[0038] (1) Weigh 5 parts of honeysuckle, 12 parts of lily, 10 parts of ophiopogon, 1 part of Fritillaria cirrhosa, 500 parts of pear, 100 parts of honey, 10 parts of ginger, 2 parts of sorbitol, 20 parts of natural menthol, 2 parts of tsaoko, 10 parts of crystal sugar, 1300 parts of water, and 500 parts of auxiliary materials;

[0039] (2) Divide the water into two parts, the weight of the first part of the water is 1200 parts, and the rest is the second part of the water. Cut the autumn pear into small pieces of 1 cm square, and then mix it with honeysuckle, lily, ophiopogon japonicus, Fritillaria cirrhosa, ginger and the first part of the water, heat and boil for 20 minutes, filter with gauze to obtain a filtrate and a filter residue, and then squeeze the filter residue to obtain a filter residue liquid, combine the filtrate and the filter residue liquid, and then reduce the pressure and concentrate them to obtain a paste. The relative density of the paste at 50° C. is 1.37 g / cm 3 ;

[0040] (3) mixing the paste obtained in step (2) with honey, sorbitol and natural menthol, adding the second portion of water, stirring at 100 r / min for 30 min, and then sealing and storing at 30° C. for fermentation for 5 days to obtain a fermentation product;

[0041] (4) After the fermentation product is pasteurized, mix it evenly with the auxiliary materials and then heat it at 1kg / cm 2 Compress the tablets for 30 seconds to obtain honeysuckle pear paste lozenges.

[0042] Example 3

[0043] A preparation method of honeysuckle pear paste lozenges:

[0044] (1) Weigh 12 parts of honeysuckle, 10 parts of lily, 8 parts of ophiopogon, 2 parts of Fritillaria cirrhosa, 1200 parts of pear, 80 parts of honey, 7 parts of ginger, 3 parts of sorbitol, 15 parts of natural menthol, 3 parts of tsaoko, 6 parts of crystal sugar, 1100 parts of water, and 700 parts of auxiliary materials;

[0045] (2) Divide the water into two parts, the weight of the first part of the water is 1000 parts, and the rest is the second part of the water. Cut the autumn pear into small pieces of 1 cm square, and then mix it with honeysuckle, lily, ophiopogon japonicus, Fritillaria cirrhosa, ginger and the first part of the water, heat and boil for 15 minutes, filter with gauze to obtain a filtrate and a filter residue, and then squeeze the filter residue to obtain a filter residue liquid, combine the filtrate and the filter residue liquid, and then reduce the pressure and concentrate them to obtain a paste. The relative density of the paste at 50° C. is 1.37 g / cm 3 ;

[0046] (3) mixing the paste obtained in step (2) with honey, sorbitol and natural menthol, adding the second portion of water, stirring at 125 r / min for 45 min, and then sealing and storing at 35° C. for fermentation for 4 days to obtain a fermentation product;

[0047] (4) After the fermentation product is pasteurized, mix it evenly with the auxiliary materials and then heat it at 3kg / cm 2 The tablets were compressed for 15 seconds to obtain honeysuckle pear paste lozenges.

[0048] Example 4

[0049] A preparation method of honeysuckle pear paste lozenges:

[0050] (1) Weigh 8 parts of honeysuckle, 11 parts of lily, 9 parts of ophiopogon, 3 parts of Fritillaria cirrhosa, 1300 parts of pear, 100 parts of honey, 6 parts of ginger, 3 parts of sorbitol, 12 parts of natural menthol, 4 parts of tsaoko, 5 parts of crystal sugar, 1000 parts of water, and 800 parts of auxiliary materials;

[0051] (2) Divide the water into two parts, the weight of the first part of the water is 900 parts, and the rest is the second part of the water. Cut the autumn pear into small pieces of 1 cm square, and then mix it with honeysuckle, lily, ophiopogon japonicus, Fritillaria cirrhosa, ginger and the first part of the water, heat and boil for 25 minutes, filter with gauze to obtain a filtrate and a filter residue, and then squeeze the filter residue to obtain a filter residue liquid, combine the filtrate and the filter residue liquid, and then reduce the pressure and concentrate them to obtain a paste. The relative density of the paste at 50° C. is 1.37 g / cm 3 ;

[0052] (3) mixing the paste obtained in step (2) with honey, sorbitol and natural menthol, adding the second portion of water, stirring at 130 r / min for 40 min, and then sealing and storing at 40° C. for fermentation for 3 days to obtain a fermentation product;

[0053] (4) After the fermentation product is pasteurized, mix it evenly with the auxiliary materials and then heat it at 5 kg / cm 2 The tablets were compressed for 10 seconds to obtain honeysuckle pear paste lozenges.

[0054] Test Example 1

[0055] The single piece of honeysuckle pear paste lozenge (single piece weighs about 1g) prepared in Example 4 was crushed, then dissolved in 20ml of water, stirred evenly, and a dispersion was obtained as a high-dose group. The single piece of honeysuckle pear paste lozenge (single piece weighs about 1g) prepared in Example 4 was crushed, then dissolved in 40ml of water, stirred evenly, and a dispersion was obtained as a medium-dose group. The single piece of honeysuckle pear paste lozenge (single piece weighs about 1g) prepared in Example 4 was crushed, then dissolved in 60ml of water, stirred evenly, and a dispersion was obtained as a low-dose group. 1g of a certain brand of commercially available autumn pear paste was dissolved in 20ml of water as a control group.

[0056] Fifty SPF Kunming mice were evenly divided into a blank group (feeding amount: 20 ml distilled water / kg), a control group (feeding amount: 20 ml / kg), a low-dose group (feeding amount: 20 ml / kg), a medium-dose group (feeding amount: 20 ml / kg) and a high-dose group (feeding amount: 20 ml / kg).

[0057] The drug was administered by intragastric administration. One hour after the administration, each mouse was sprayed with 0.5 ml of 15% ammonia water. The coughing time caused by the spraying of ammonia water was then calculated. The results are shown in Table 1.

[0058] Table 1

[0059]

[0060] The results show that the honeysuckle pear paste lozenges prepared by the present invention can significantly prolong the coughing time of mice after spraying ammonia water, and have an excellent cough-relieving effect.

[0061] Test Example 2

[0062] 50 volunteers with a history of pharyngitis were selected, including 32 males and 18 females, aged 12-50 years old. They were randomly divided into 5 groups, wherein groups 1-4 took 1 tablet of honeysuckle pear paste prepared by embodiments 1-4 of the present invention daily, and groups 5 took 1g of a commercially available brand of autumn pear paste daily. After continuous use for 90 days, they were revisited to judge the recurrence of pharyngitis, and the results are shown in Table 2.

[0063] Table 2

[0064] project Significant effect (people) Effective (person) Invalid (person) 1 group 6 3 1 2 groups 7 1 2 3 groups 6 4 0 4 groups 8 2 0 5 groups 2 2 6

[0065] Among them, marked effect means no symptoms of pharyngitis occurred within 90 days, effective means mild symptoms of pharyngitis occurred within 90 days, and ineffective means almost no change compared with previous years.

[0066] The experimental results show that the effective honeysuckle pear paste lozenges prepared by the present invention can effectively inhibit the recurrence of pharyngitis, have a good cough-relieving and lung-moistening effect, have an obvious auxiliary therapeutic effect on respiratory diseases such as cough and pharyngitis, and play a significant positive role in the maintenance of the daily respiratory system.

[0067] Although the embodiments of the present invention have been shown and described above, it is to be understood that the above embodiments are exemplary and are not to be construed as limitations of the present invention. A person skilled in the art may change, modify, replace and vary the above embodiments within the scope of the present invention.

Claims

1. A honeysuckle pear paste lozenge, characterized in that: The invention comprises the following raw materials in parts by weight: 5-15 parts of honeysuckle, 8-12 parts of lily, 5-10 parts of ophiopogon, 1-3 parts of Fritillaria cirrhosa, 500-1500 parts of pear, 70-100 parts of honey, 6-10 parts of ginger, 2-5 parts of sorbitol, 10-20 parts of natural menthol, 2-5 parts of tsaoko, 1-10 parts of crystal sugar, 900-1300 parts of water and 500-1000 parts of auxiliary materials.

2. A honeysuckle pear paste lozenge according to claim 1, characterized in that: The auxiliary materials include maltodextrin, maltose, white sugar, mannitol and citric acid.

3. A honeysuckle pear paste buccal tablet according to claim 2, characterized in that, The mass ratio of the maltodextrin, maltose, white sugar, mannitol and citric acid is 100:15-25:80-120:50-150:2-10.

4. The honeysuckle pear paste lozenge according to claim 1, characterized in that: The pear is autumn pear or duck pear.

5. A method for preparing honeysuckle pear paste tablets, characterized in that: The following steps are involved: (1) Weighing each raw material according to the weight proportions described in any one of claims 1 to 4; (2) Divide the water into two parts, cut the pear into small pieces of 1 cm square, then mix the small pieces with honeysuckle, lily, ophiopogon japonicus, Fritillaria cirrhosa, ginger and the first part of water, heat and boil for 20-30 minutes, filter with gauze to obtain a filtrate and a filter residue, squeeze the filter residue to obtain a filter residue liquid, combine the filtrate and the filter residue liquid, and then concentrate under reduced pressure to obtain a paste; (3) mixing the paste obtained in step (2) with honey, sorbitol and natural menthol, adding the second portion of water, stirring evenly, and then sealing and storing for fermentation to obtain a fermented product; (4) sterilizing the fermented product and then mixing it evenly with the auxiliary materials, and then pressing the product into tablets to obtain honeysuckle pear paste lozenges.

6. The method for preparing the honeysuckle pear paste buccal tablet according to claim 5, characterized in that: In step (2), the weight proportion of the first part of water is 800-1200 parts, and the remainder is the second part of water.

7. The method for preparing the honeysuckle pear paste buccal tablet according to claim 5, characterized in that: The relative density of the paste obtained by the reduced pressure concentration in step (2) at 50°C is 1.3-1.4 g / cm 3 .

8. The method for preparing the honeysuckle pear paste buccal tablet according to claim 5, characterized in that: The stirring rate in step (3) is 100-150 r / min, and the stirring time is 30-50 min.

9. The method for preparing the honeysuckle pear paste buccal tablet according to claim 5, characterized in that: The fermentation temperature in step (3) is 30-40° C. and the fermentation time is 3-5 days.

10. The method for preparing the honeysuckle pear paste buccal tablet according to claim 5, characterized in that: The sterilization in step (4) is pasteurization; The tableting pressure is 1-5 kg / cm 2 , the tableting time is 10-30s.

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