Extraction process and method for extracting platycodin D from platycodon grandiflorum

Abstract

The invention relates to the technical field of medicinal material treatment equipment, in particular to an extraction process and method for extracting platycodin D. The extraction process comprises extraction equipment for extracting platycodin D of platycodon grandiflorum, the extraction equipment further comprises an ultrasonic extraction tank, and a plurality of ultrasonic oscillators are fixedly connected to the lower portion of the inner surface of the ultrasonic extraction tank. The left side of the upper end of the ultrasonic extraction tank is fixedly connected with a feeding port, the right side of the upper end of the ultrasonic extraction tank is fixedly connected with a water injection port, the middle of the upper end of the ultrasonic extraction tank is fixedly connected with a first motor, and the output end of the first motor penetrates through the upper end of the ultrasonic extraction tank and is fixedly connected with a stirring mechanism. According to the extraction process and method for extracting platycodin D from platycodon grandiflorum, the deslagging mechanism is arranged at the lower part of the ultrasonic extraction tank, and after the device is used, a second motor in the deslagging mechanism can be started to drive an auger blade to rotate, so that residues accumulated in the tank can be discharged outwards through the rotation of the auger blade; and internal cleaning of the device is more convenient.

Description

Technical Field

[0001] The invention relates to the technical field of medicinal material processing equipment, and in particular to an extraction process and method for extracting platycodon saponin D from platycodon grandiflorum. Background Art

[0002] With the rapid development of modern medicine and health care products industry, the demand for natural plant extracts is growing. Platycodon grandiflorum, as a common Chinese herbal medicine, is widely used in medicine and health care products because of its effects of clearing lung, relieving throat, removing phlegm, and draining pus. Platycodon grandiflorum saponin D, as the main chemical component of Platycodon grandiflorum, has significant biological activity, and its extraction and purification technology has become a hot topic of research;

[0003] In the ultrasonic extraction method, the extraction of Platycodon grandiflorum completely relies on the ultrasonic wave to break the wall of Platycodon grandiflorum cells so that they are combined with the solvent, which makes the operation efficiency low. After the extraction is completed, there will be residues inside the ultrasonic extraction tank, and it is very inconvenient to clean the remaining residues through the feeding port. Therefore, we introduced a new extraction process and method for extracting Platycodon saponin D from Platycodon grandiflorum. Summary of the invention

[0004] The main purpose of the present invention is to provide an extraction process and method for extracting platycodon saponin D from platycodon grandiflorum, which can effectively solve the problems in the background technology.

[0005] To achieve the above object, the technical solution adopted by the present invention is:

[0006] The invention discloses an extraction process and method for extracting platycoside D from platycodon grandiflorum, comprising an extraction device for extracting platycoside D from platycodon grandiflorum, the extraction device also comprising an ultrasonic extraction tank, a plurality of ultrasonic oscillators are fixedly connected to the lower part of the inner surface of the ultrasonic extraction tank, a feeding port is fixedly connected to the left side of the upper end of the ultrasonic extraction tank, a water injection port is fixedly connected to the right side of the upper end of the ultrasonic extraction tank, a first motor is fixedly connected to the middle part of the upper end of the ultrasonic extraction tank, an output end of the first motor passes through the upper end of the ultrasonic extraction tank and is fixedly connected to a stirring mechanism, a slag discharge mechanism and three supporting legs are fixedly connected to the lower part of the outer surface of the ultrasonic extraction tank, and an external pipe is fixedly connected to the middle part of the lower end of the ultrasonic extraction tank.

[0007] Preferably, the plurality of ultrasonic oscillators and the three supporting legs are equidistantly distributed in a circular array and do not contact each other, the stirring mechanism is located inside the ultrasonic extraction tank and does not contact the ultrasonic extraction tank and the plurality of ultrasonic oscillators, and the slag discharge mechanism and the external pipe are located between the three supporting legs and do not contact each other.

[0008] Preferably, the stirring mechanism comprises a fixed rod, and six stirring blades are fixedly connected to the lower portion of the outer surface of the fixed rod, and the six stirring blades are each provided with a first through groove and a second through groove at the traveling ends.

[0009] By adopting the above technical solution: the stirring mechanism can stir the extract and the solution in the tank so that they can be more fully blended.

[0010] Preferably, the fixing rod is fixedly connected to the output end of the first motor, the six stirring blades are distributed in an equidistant circular array and do not contact each other, and the six second through grooves are respectively located inside the six first through grooves and do not contact each other.

[0011] By adopting the above technical solution, the two through grooves opened in the stirring blade can generate a swirling flow when stirring the liquid, so that the liquid can be blended more thoroughly.

[0012] Preferably, the slag discharge mechanism includes a collecting pipe, a discharge pipe is fixedly connected to the rear left portion of the outer surface of the collecting pipe, a sealing cover is threadedly connected to the rear portion of the outer surface of the discharge pipe, a collecting groove is provided at the upper right portion of the outer surface of the collecting pipe, a second motor is fixedly connected to the left end of the collecting pipe, the output end of the second motor passes through the collecting pipe and is fixedly connected to an auger blade, an installation groove is provided at the lower left portion of the outer surface of the ultrasonic extraction tank, a drainage hole is provided in the middle portion of the lower side of the inner surface of the installation groove, and a filter valve is fixedly installed at the upper portion of the inner surface of the drainage hole.

[0013] By adopting the above technical solution: the slag discharge mechanism can discharge the residue accumulated in the tank through the rotation of the auger blades, which is convenient for the cleaning operation after the use of the device.

[0014] Preferably, the collecting tube is interlaced and fixedly connected with the mounting groove, the discharge pipe is located outside the ultrasonic extraction tank and does not contact the ultrasonic extraction tank, the collecting tank is located inside the ultrasonic extraction tank, and the auger blades are located inside the collecting tube.

[0015] By adopting the above technical solution: the collection groove in the collection pipe is located at the lower side of the installation groove, which facilitates the residue in the tank to slide directly into the collection groove, thereby facilitating the collection and discharge of the residue.

[0016] Preferably, the filter valve is located at the lower part of the collecting pipe and does not contact the collecting pipe, and there is a flow gap between the collecting pipe and the installation groove at the position of the drainage hole.

[0017] By adopting the above technical solution, the filter valve inside the liquid discharge hole can filter the discharged liquid, thereby improving the purity of the discharged liquid.

[0018] A method for extracting platycodon saponin D from platycodon grandiflorum comprises the following steps:

[0019] Step S1, crushing: placing the washed and dried Platycodon grandiflorum in a crusher for sieving and filtering;

[0020] Step S2, extraction: extracting the crushed platycodon grandiflorum in step S1, at 35-75° C., the first motor can drive the stirring mechanism to rotate, so that the extract inside the ultrasonic extraction tank can be more thoroughly blended with the solvent, which can accelerate the reaction between the platycodon grandiflorum cells and the solvent, and extracting 2-3 times with an ethanol solution with a concentration of 75-90%, and then filtering to obtain an extract;

[0021] Step S3, waste residue discharge: the second motor drives the auger blade to rotate, so that the residue accumulated in the tank can be discharged outward through the rotation of the auger blade to clean the inside;

[0022] Step S4, first filtration: ultrafiltration, using a membrane to separate the extract obtained in step S2, and collecting the ultrafiltrate and the concentrated solution;

[0023] Step S5, second filtration: Second nanofiltration: The ultrafiltrate in step S2 is separated by membrane, the obtained nanofiltrate and concentrated solution are collected again, and the concentrated solution is dried to obtain a dry product;

[0024] Step S6, extraction of platycoside D: recrystallization: add solvent to the dried product of step S5 at 60-120°C to dissolve it, add activated carbon for decolorization for 1-2h, filter, add 0.1-0.5 times the amount of acetone solution of the solvent, crystallize, filter, and obtain a white powdery substance, which is platycoside D.

[0025] Compared with the prior art, the present invention has the following beneficial effects:

[0026] 1. The present invention provides a stirring mechanism inside the ultrasonic extraction tank. When the device is used, the first motor can drive the stirring mechanism to rotate, so that the extract inside the ultrasonic extraction tank can be more thoroughly blended with the solvent, which can accelerate the reaction of the Platycodon grandiflorum cells and the solvent. The two through grooves provided in the stirring blades of the stirring mechanism can make the liquid pass through the through grooves to form a vortex flow during the stirring process, further accelerating the blending of the Platycodon grandiflorum cells and the solvent, and greatly improving the extraction operation efficiency of the Platycodon grandiflorum cells.

[0027] 2. The present invention provides a slag discharge mechanism at the bottom of the ultrasonic extraction tank. After the device is used, the second motor in the slag discharge mechanism can be started to drive the auger blades to rotate, so that the residue accumulated in the tank can be discharged outward through the rotation of the auger blades, which is more convenient for internal cleaning of the device. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 It is a schematic diagram of the overall structure of an extraction process and method of platycodon saponin D from platycodon grandiflorum according to the present invention;

[0029] Figure 2 A schematic diagram of the internal structure of an ultrasonic extraction tank for extracting platycodon saponin D from platycodon grandiflorum according to the present invention;

[0030] Figure 3 It is a schematic diagram of the overall structure of a stirring mechanism of an extraction process and method for extracting platycodon saponin D from platycodon grandiflorum according to the present invention;

[0031] Figure 4 The present invention is a schematic diagram of the overall structure of a slag discharge mechanism of an extraction process and method for extracting platycodon saponin D from platycodon grandiflorum.

[0032] In the figure: 1. ultrasonic extraction tank; 2. ultrasonic oscillator; 3. feeding port; 4. water injection port; 5. first motor; 6. stirring mechanism; 7. slag discharge mechanism; 8. supporting legs; 9. external pipe; 61. fixing rod; 62. stirring blade; 63. first through groove; 64. second through groove; 71. collecting pipe; 72. discharge pipe; 73. sealing cover; 74. collecting tank; 75. second motor; 76. auger blade; 77. mounting groove; 78. drainage hole; 79. filter valve. DETAILED DESCRIPTION

[0033] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further explained below in conjunction with specific implementation methods.

[0034] In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "front end", "rear end", "two ends", "one end", "the other end" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first" and "second" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance.

[0035] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "provided with", "connected", etc. should be understood in a broad sense. For example, "connected" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0036] See also Figure 1-4 , the present invention provides a technical solution:

[0037] The invention discloses an extraction process and method for extracting platycoside D from platycodon grandiflorum, comprising an extraction device for extracting platycoside D from platycodon grandiflorum. The extraction device also comprises an ultrasonic extraction tank 1, wherein a plurality of ultrasonic oscillators 2 are fixedly connected to the lower part of the inner surface of the ultrasonic extraction tank 1, a feeding port 3 is fixedly connected to the left side of the upper end of the ultrasonic extraction tank 1, a water injection port 4 is fixedly connected to the right side of the upper end of the ultrasonic extraction tank 1, a first motor 5 is fixedly connected to the middle part of the upper end of the ultrasonic extraction tank 1, an output end of the first motor 5 passes through the upper end of the ultrasonic extraction tank 1 and is fixedly connected to a stirring mechanism 6, a slag discharge mechanism 7 and three supporting legs 8 are fixedly connected to the lower part of the outer surface of the ultrasonic extraction tank 1, an external pipe 9 is fixedly connected to the middle part of the lower end of the ultrasonic extraction tank 1, the plurality of ultrasonic oscillators 2 and the three supporting legs 8 are evenly distributed in a circular array and do not contact each other, the stirring mechanism 6 is located inside the ultrasonic extraction tank 1 and does not contact the ultrasonic extraction tank 1 and the plurality of ultrasonic oscillators 2, and the slag discharge mechanism 7 and the external pipe 9 are both located between the three supporting legs 8 and do not contact each other.

[0038] In this embodiment, the stirring mechanism 6 includes a fixed rod 61, and six stirring blades 62 are fixedly connected to the lower part of the outer surface of the fixed rod 61. The six stirring blades 62 are provided with a first through groove 63 and a second through groove 64 at the moving ends. The fixed rod 61 is fixedly connected to the output end of the first motor 5. The six stirring blades 62 are distributed in an equidistant circular array and do not contact each other. The six second through grooves 64 are respectively located inside the six first through grooves 63 and do not contact each other.

[0039] Through the above scheme: by arranging a stirring mechanism 6 inside the ultrasonic extraction tank 1, when the device is used, the first motor 5 can drive the stirring mechanism 6 to rotate, so that the extract inside the ultrasonic extraction tank 1 can be more thoroughly blended with the solvent, which can accelerate the reaction of Platycodon grandiflorum cells and the solvent.

[0040] In this embodiment, the slag discharge mechanism 7 includes a collecting pipe 71, a discharge pipe 72 is fixedly connected to the rear left portion of the outer surface of the collecting pipe 71, a sealing cover 73 is threadedly connected to the rear portion of the outer surface of the discharge pipe 72, a collecting groove 74 is provided on the upper right portion of the outer surface of the collecting pipe 71, a second motor 75 is fixedly connected to the left end of the collecting pipe 71, the output end of the second motor 75 passes through the collecting pipe 71 and is fixedly connected to an auger blade 76, a mounting groove 77 is provided on the lower left portion of the outer surface of the ultrasonic extraction tank 1, a drainage hole 78 is provided in the middle portion of the lower side of the inner surface of the mounting groove 77, a filter valve 79 is fixedly installed on the upper portion of the inner surface of the drainage hole 78, the collecting pipe 71 is fixedly connected with the mounting groove 77 through insertion, the discharge pipe 72 is located outside the ultrasonic extraction tank 1 and does not contact the ultrasonic extraction tank 1, the collecting groove 74 is located inside the ultrasonic extraction tank 1, the auger blade 76 is located inside the collecting pipe 71, the filter valve 79 is located at the lower portion of the collecting pipe 71 and does not contact, and there is a flow gap between the collecting pipe 71 and the mounting groove 77 at the position of the drainage hole 78.

[0041] Through the above scheme: by arranging a slag discharge mechanism 7 at the lower part of the ultrasonic extraction tank 1, after the use of the device, the second motor 75 in the slag discharge mechanism 7 can be started to drive the auger blade 76 to rotate, so that the residue accumulated in the tank can be discharged outwardly through the rotation of the auger blade 76, which is more convenient for the internal cleaning of the device.

[0042] like Figure 1-4 As shown, an extraction method of extracting platycodon saponin D from platycodon grandiflorum comprises the following steps:

[0043] Step S1, crushing: placing the washed and dried Platycodon grandiflorum in a crusher for sieving and filtering;

[0044] Step S2, extraction: extracting the ground Platycodon grandiflorum in step S1, at 35-75° C., the first motor 5 can drive the stirring mechanism 6 to rotate, so that the extract inside the ultrasonic extraction tank 1 can be more thoroughly blended with the solvent, which can accelerate the reaction between Platycodon grandiflorum cells and the solvent, and extracting 2-3 times with an ethanol solution with a concentration of 75-90%, and then filtering to obtain an extract;

[0045] Step S3, waste residue discharge: the second motor 75 drives the auger blade 76 to rotate, so that the residue accumulated in the tank can be discharged outward through the rotation of the auger blade 76 to clean the interior;

[0046] Step S4, first filtration: ultrafiltration, using a membrane to separate the extract obtained in step S2, and collecting the ultrafiltrate and the concentrated solution;

[0047] Step S5, second filtration: Second nanofiltration: The ultrafiltrate in step S2 is separated by membrane, the obtained nanofiltrate and concentrated solution are collected again, and the concentrated solution is dried to obtain a dry product;

[0048] Step S6, extraction of platycoside D: recrystallization: add solvent to the dried product of step S5 at 60-120°C to dissolve it, add activated carbon for decolorization for 1-2h, filter, add 0.1-0.5 times the amount of acetone solution of the solvent, crystallize, filter, and obtain a white powdery substance, which is platycoside D.

[0049] It should be noted that the present invention is an extraction process and method for extracting platycodon saponin D from platycodon grandiflorum. The equipment significantly improves the reaction efficiency of platycodon grandiflorum cells and solvent and the purity of the extract by integrating ultrasonic extraction and stirring functions.

[0050] Specifically, the device is mainly composed of an ultrasonic extraction tank 1, which is designed with a unique stirring mechanism 6 inside. When the device is running, the first motor 5 will drive the stirring mechanism 6 to rotate. This action promotes the extract and solvent in the ultrasonic extraction tank 1 to be mixed more fully. This mixing not only speeds up the reaction rate of Platycodon grandiflorum cells and solvent, but also ensures the thoroughness of the extraction process.

[0051] It is worth noting that the stirring blades 62 in the stirring mechanism 6 are designed with through grooves. The two through grooves can make the liquid form a vortex flow during the stirring process. This vortex flow further enhances the mixing effect of Platycodon grandiflorum cells and the solvent, thereby greatly improving the extraction efficiency of Platycodon grandiflorum cells.

[0052] In addition, a slag discharge mechanism 7 is provided at the bottom of the ultrasonic extraction tank 1. When the extraction process is completed, the second motor 75 will drive the auger blade 76 in the slag discharge mechanism 7 to rotate, thereby smoothly discharging the residue accumulated in the tank. This design not only facilitates the internal cleaning of the equipment, but also ensures the cleanliness and efficiency of the equipment when it is used next time.

[0053] A drainage hole 78 is provided at the lower part of the inner surface of the mounting groove 77 for fixing the slag discharge mechanism 7 on the inner lower wall of the ultrasonic extraction tank 1. When the drainage operation is performed, the liquid will flow into the drainage hole 78 through the gap between the slag discharge mechanism 7 and the mounting groove 77, and be filtered by the filter valve 79, thereby ensuring the purity of the discharged liquid.

[0054] The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited to the above embodiments. The above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention to be protected. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A process for extracting platycodon saponin D from Platycodon grandiflorum, characterized in that: The invention relates to an extraction device for extracting platycodon saponin D from platycodon grandiflorum. The extraction device also comprises an ultrasonic extraction tank (1), wherein a plurality of ultrasonic oscillators (2) are fixedly connected to the lower part of the inner surface of the ultrasonic extraction tank (1), a feeding port (3) is fixedly connected to the left side of the upper end of the ultrasonic extraction tank (1), a water injection port (4) is fixedly connected to the right side of the upper end of the ultrasonic extraction tank (1), a first motor (5) is fixedly connected to the middle part of the upper end of the ultrasonic extraction tank (1), an output end of the first motor (5) passes through the upper end of the ultrasonic extraction tank (1) and is fixedly connected to a stirring mechanism (6), a slag discharge mechanism (7) and three supporting legs (8) are fixedly connected to the lower part of the outer surface of the ultrasonic extraction tank (1), and an external pipe (9) is fixedly connected to the middle part of the lower end of the ultrasonic extraction tank (1); The stirring mechanism (6) comprises a fixed rod (61), six stirring blades (62) are fixedly connected to the lower portion of the outer surface of the fixed rod (61), and the six stirring blades (62) are each provided with a first through groove (63) and a second through groove (64) at the travel ends.

2. The extraction equipment for extracting platycodon saponin D from Platycodon grandiflorum according to claim 1, characterized in that: The plurality of ultrasonic oscillators (2) and the three supporting legs (8) are evenly spaced and distributed in a circular array and do not contact each other; the stirring mechanism (6) is located inside the ultrasonic extraction tank (1) and does not contact the ultrasonic extraction tank (1) and the plurality of ultrasonic oscillators (2); and the slag discharge mechanism (7) and the external pipe (9) are located between the three supporting legs (8) and do not contact each other.

3. The extraction equipment for extracting platycoside D from Platycodon grandiflorum according to claim 1, characterized in that: The fixing rod (61) is fixedly connected to the output end of the first motor (5); the six stirring blades (62) are distributed in an equidistant circular array and do not contact each other; and the six second through slots (64) are respectively located inside the six first through slots (63) and do not contact each other.

4. The extraction equipment for extracting platycodon saponin D from Platycodon grandiflorum according to claim 1, characterized in that: The slag discharge mechanism (7) comprises a collecting pipe (71), a discharge pipe (72) is fixedly connected to the rear left side of the outer surface of the collecting pipe (71), a sealing cover (73) is threadedly connected to the rear part of the outer surface of the discharge pipe (72), a collecting groove (74) is provided at the upper right side of the outer surface of the collecting pipe (71), a second motor (75) is fixedly connected to the left end of the collecting pipe (71), an output end of the second motor (75) passes through the collecting pipe (71) and is fixedly connected to an auger blade (76), a mounting groove (77) is provided at the lower left side of the outer surface of the ultrasonic extraction tank (1), a drainage hole (78) is provided at the middle part of the lower side of the inner surface of the mounting groove (77), and a filter valve (79) is fixedly installed at the upper part of the inner surface of the drainage hole (78).

5. The extraction equipment for extracting platycoside D from Platycodon grandiflorum according to claim 4, characterized in that: The collecting pipe (71) is interlaced and fixedly connected with the mounting groove (77); the discharge pipe (72) is located outside the ultrasonic extraction tank (1) and does not contact the ultrasonic extraction tank (1); the collecting tank (74) is located inside the ultrasonic extraction tank (1); and the auger blade (76) is located inside the collecting pipe (71).

6. The extraction equipment for extracting platycoside D from Platycodon grandiflorum according to claim 4, characterized in that: The filter valve (79) is located at the lower part of the collecting pipe (71) and is not in contact with the collecting pipe (71), and there is a flow gap between the collecting pipe (71) and the installation groove (77) at the position of the drainage hole (78).

7. The method for extracting platycodon saponin D from platycodon grandiflorum according to any one of claims 1 to 7, characterized in that: The following steps are involved: Step S1, crushing: placing the washed and dried Platycodon grandiflorum in a crusher for sieving and filtering; Step S2, extraction: extracting the ground Platycodon grandiflorum in step S1, at 35-75° C., the first motor (5) can drive the stirring mechanism (6) to rotate, so that the extract inside the ultrasonic extraction tank (1) can be more thoroughly blended with the solvent, which can accelerate the reaction between Platycodon grandiflorum cells and the solvent, extracting 2-3 times with an ethanol solution with a concentration of 75-90%, and then filtering to obtain an extract; Step S3, waste residue discharge: the second motor (75) drives the auger blade (76) to rotate, so that the residue accumulated in the tank can be discharged outward through the rotation of the auger blade (76) to clean the interior; Step S4, first filtration: ultrafiltration, using a membrane to separate the extract obtained in step S2, and collecting the ultrafiltrate and the concentrated solution; Step S5, second filtration: Second nanofiltration: The ultrafiltrate in step S2 is separated by membrane, the obtained nanofiltrate and concentrated solution are collected again, and the concentrated solution is dried to obtain a dry product; Step S6, extraction of platycoside D: recrystallization: add solvent to the dried product of step S5 at 60-120°C to dissolve it, add activated carbon for decolorization for 1-2h, filter, add 0.1-0.5 times the amount of acetone solution of the solvent, crystallize, filter, and obtain a white powdery substance, which is platycoside D.

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