Advanced preparation process and wide application of high-purity glassine

Abstract

The invention provides an advanced preparation process and wide application of high-purity bose, and belongs to the technical field of chemical engineering, pharmacy and cosmetics. In the field of cosmetics, the high-purity bose can improve the quality and ensure that the anti-aging effect and other effects are excellent, the additive amount is proper, skin aging can be effectively resisted, impurities are reduced, safety risks are reduced, and in the field of medicine, the high-purity bose has good application prospects. The high-purity glassy pigment can be used as an active component or an auxiliary material, the high-purity glassy pigment can ensure the effectiveness and safety of the medicine, is convenient for doctors to accurately determine the dosage, selects and pretreats specific raw materials, accurately controls reaction conditions and advanced separation and purification technologies from the aspect of the process, removes impurities to ensure the purity of the product, and is stable in storage and transportation, low in cost and high in competitiveness. A reliable scheme is provided for the industry, the prospect is wide, and social and economic values are achieved.

Description

Technical Field

[0001] The invention belongs to the technical field of chemical engineering, pharmaceuticals and cosmetics, and specifically relates to an advanced preparation process of high-purity bosogenin and its wide application. Background Art

[0002] In today's cosmetics and pharmaceutical fields, the demand for high-purity active ingredients is growing. As a valuable substance, Bossagra has shown excellent effects in anti-aging, moisturizing, and repairing. Whether it is used to improve product quality in cosmetics or to treat diseases or symptoms related to skin repair and anti-aging in the pharmaceutical field, it has broad application prospects.

[0003] However, existing bosogen preparation processes often have problems such as low purity and poor stability. Low-purity bosogen may affect the efficacy of the product and may introduce impurities, posing potential safety risks. At the same time, during storage and transportation, if bosogen is not stable enough, it is easy to decompose or deteriorate, which will not only reduce its use value, but may also have a negative impact on the quality of related products.

[0004] Therefore, developing a preparation process for high-purity phosgene to meet the market demand for high-quality phosgene has become an urgent problem to be solved in the current cosmetics and pharmaceutical industries. Summary of the invention

[0005] The purpose of the present invention is to provide an advanced preparation process of high-purity boson and its wide application, aiming to solve the problems in the prior art.

[0006] To achieve the above object, the present invention provides the following technical solutions:

[0007] A preparation process of high-purity boson, characterized in that it comprises the following steps:

[0008] Step 1: Select specific raw materials, wherein the raw materials include substance X which is a hydroxypropyl tetrahydropyrantriol precursor compound, substance Y which is methyl propanediol, and substance Z which is propylene glycol. The purity of substance X is not less than 99.5%, the purity of substance Y is not less than 99%, and the purity of substance Z is not less than 98.5%. The raw materials are pretreated, substance X is dried at a temperature of 50°C-60°C for 2-3 hours; substance Y is dissolved in a specific solvent and filtered to remove insoluble impurities; substance Z is activated in a vacuum environment for 1-2 hours.

[0009] Step 2: The key synthesis reaction is carried out through precisely controlled chemical reaction conditions. The reaction is carried out in a reactor. The reaction temperature is controlled at 80°C-90°C, the pressure is maintained at 0.5MPa-0.8MPa, the reaction time is 5-6 hours, and the catalyst is selected as catalyst A, and the amount used is 0.5%-1% of the total mass of the raw materials to generate an intermediate product containing bosine.

[0010] Step 3: Using advanced separation and purification technology, first use chromatographic separation, select a specific chromatographic column, the mobile phase is a mixture of solution B and solution C in a volume ratio of 3:1, the flow rate is controlled at 1-2mL / min, and the target product fraction is collected. Then crystallization is performed at a temperature of 10℃-15℃ for 3-4 hours to obtain a high-purity bosine product.

[0011] As a preferred solution of the present invention, the specific raw material selection and pretreatment method includes strict screening, testing and specific physical or chemical treatment of the raw materials to remove impurities that may affect the purity of boson.

[0012] As a preferred solution of the present invention, the precisely controlled chemical reaction conditions include reaction temperature, pressure, reaction time, selection and dosage of catalyst, etc., to ensure efficient synthesis reaction and purity of the product.

[0013] As a preferred solution of the present invention, the advanced separation and purification technology includes but is not limited to chromatography, crystallization, membrane separation and other methods to effectively remove impurities in intermediate products and final products.

[0014] As a preferred solution of the present invention, the process can prepare bosone with a purity of more than 99.9%, and the purity is determined by high performance liquid chromatography.

[0015] As a preferred solution of the present invention, the process is repeatable and stable, and can maintain the quality of high-purity bosogen in different production batches.

[0016] As a preferred solution of the present invention, it has specific physical and chemical properties and purity indicators and can be widely used in the fields of cosmetics, medicine, etc.

[0017] As a preferred solution of the present invention, it can be used to prepare cosmetic products with anti-aging, moisturizing, repairing and other effects, and the added amount in the cosmetics is 0.5%-5%.

[0018] As a preferred solution of the present invention, it can be used as a pharmaceutical active ingredient or excipient to treat diseases or symptoms related to skin repair and anti-aging, and the dosage in the medicine is determined according to the specific disease and dosage form.

[0019] As a preferred solution of the present invention, it has good stability during storage and transportation, and can be stably stored for more than 24 months under the conditions of a temperature of 5°C-25°C and a relative humidity not exceeding 60%, and is not easy to decompose or deteriorate.

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] In the field of cosmetics, the high-purity phosphene prepared by this process can greatly improve the quality of cosmetics. phosphene with a purity of more than 99.9% can ensure that cosmetics have excellent performance in anti-aging, moisturizing, repair and other effects. The addition of 0.5%-5% high-purity phosphene can make cosmetics more effectively fight skin aging and bring significant beauty effects to consumers. At the same time, high-purity phosphene reduces the presence of impurities and reduces potential safety risks, making consumers feel more at ease when using it. Secondly, in the field of medicine, high-purity phosphene can be used as an active ingredient or excipient for the treatment of diseases or symptoms related to skin repair and anti-aging. Its high purity ensures the effectiveness and safety of the drug. Doctors can accurately determine the dosage according to the specific symptoms and dosage form, and provide patients with more accurate treatment plans. Furthermore, from the perspective of the preparation process itself, specific raw material selection and pretreatment methods , strictly screen, test and perform physical or chemical treatment of raw materials to remove impurities that affect the purity of boson; precisely control chemical reaction conditions, such as specific reaction temperature, pressure, reaction time, selection and dosage of catalysts, etc., to ensure the efficient progress of the synthesis reaction and the purity of the product; advanced separation and purification technologies, including chromatography, crystallization, membrane separation and other methods, to effectively remove impurities in intermediates and final products; finally, high-purity boson shows good stability during storage and transportation. It can be stably stored for more than 24 months at a temperature of 5°C-25°C and a relative humidity of no more than 60% and is not easy to decompose or deteriorate, which greatly reduces storage and transportation costs and improves the market competitiveness of the product. In short, the preparation process of high-purity boson provides a reliable solution for the cosmetics and pharmaceutical industries, with broad application prospects and important social and economic value. DETAILED DESCRIPTION

[0022] The technical solutions in the embodiments of the present invention will be described clearly and completely below in combination with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0023] Example 1

[0024] The present invention provides the following technical solutions:

[0025] A preparation process of high-purity boson, comprising the following steps:

[0026] Step 1: Select specific raw materials, including substance X which is a hydroxypropyl tetrahydropyrantriol precursor compound, substance Y which is methyl propanediol, and substance Z which is propylene glycol. The purity of substance X is not less than 99.5%, the purity of substance Y is not less than 99%, and the purity of substance Z is not less than 98.5%. Pre-treat the raw materials, dry substance X at a temperature of 50°C-60°C for 2-3 hours; dissolve substance Y in a specific solvent and filter to remove insoluble impurities; activate substance Z in a vacuum environment for 1-2 hours.

[0027] Step 2: The key synthesis reaction is carried out through precisely controlled chemical reaction conditions. The reaction is carried out in a reactor. The reaction temperature is controlled at 80°C-90°C, the pressure is maintained at 0.5MPa-0.8MPa, the reaction time is 5-6 hours, and the catalyst is selected as catalyst A, and the amount used is 0.5%-1% of the total mass of the raw materials to generate an intermediate product containing bosine.

[0028] Step 3: Using advanced separation and purification technology, first use chromatographic separation, select a specific chromatographic column, the mobile phase is a mixture of solution B and solution C in a volume ratio of 3:1, the flow rate is controlled at 1-2mL / min, and the target product fraction is collected. Then crystallization is performed at a temperature of 10℃-15℃ for 3-4 hours to obtain a high-purity bosine product.

[0029] In a specific embodiment of the present invention, for substance X, its purity is controlled to be not less than 99.5%, and it is dried at 50°C-60°C for 2-3 hours, which can effectively remove moisture and prevent moisture from having adverse effects in subsequent reactions. The purity of substance Y is not less than 99%. By dissolving and filtering in a specific solvent to remove insoluble impurities, the purity of the reaction system is ensured to avoid impurities interfering with the synthesis reaction. The purity of substance Z is not less than 98.5%, and it is activated in a vacuum environment for 1-2 hours to enhance its activity and better participate in subsequent reactions. These pretreatment measures can greatly improve the purity and quality of the final product.

[0030] Specifically, the specific raw material selection and pretreatment method includes strict screening, testing and specific physical or chemical treatment of the raw materials to remove impurities that may affect the purity of boson.

[0031] In this embodiment: During the raw material selection stage, the raw materials are strictly screened to ensure that each raw material meets the high purity standard. Through testing, raw materials that do not meet the requirements can be discovered in time to prevent them from entering the production process. Specific physical or chemical treatments, such as drying treatment of substance X, dissolution and filtration of substance Y, and activation treatment of substance Z, can specifically remove impurities that may affect the purity of bosense. This not only improves the purity of bosense, but also reduces potential safety risks. In the fields of cosmetics and medicine, high-purity bosense can better exert its efficacy and bring more significant effects to consumers and patients.

[0032] Specifically, the precisely controlled chemical reaction conditions include reaction temperature, pressure, reaction time, selection and dosage of catalysts, etc., to ensure efficient synthesis reaction and purity of the product.

[0033] In this embodiment: the reaction temperature is controlled at 80°C-90°C. Within this temperature range, the reaction can be carried out efficiently, while avoiding side reactions or inadequate reactions caused by excessively high or low temperatures. The pressure is maintained at 0.5MPa-0.8MPa, providing a suitable environment for the reaction and promoting the reaction to proceed in the direction of generating high-purity boson. The reaction time is 5-6 hours to ensure that the reaction is fully completed and the yield of the product is improved. The catalyst is selected as A catalyst, and the amount used is 0.5%-1% of the total mass of the raw material. The selection of A catalyst can accelerate the reaction rate, improve the selectivity of the reaction, and reduce the generation of by-products, thereby ensuring the purity of the product.

[0034] Specifically, advanced separation and purification technologies include, but are not limited to, chromatography, crystallization, membrane separation and other methods to effectively remove impurities from intermediates and final products.

[0035] In this embodiment: Chromatographic separation can effectively separate impurities in the intermediate product according to the difference in retention time of different substances on the chromatographic column. A specific chromatographic column is selected and solution B and solution C are mixed in a volume ratio of 3:1 as the mobile phase. The flow rate is controlled at 1-2mL / min, and the target product fraction can be accurately collected to remove most impurities. Crystallization further improves the purity of Bose. Crystallization is carried out for 3-4 hours at a temperature of 10°C-15°C, so that Bose is precipitated in the form of high-purity crystals. Other separation methods such as membrane separation can also play a role at different stages to jointly ensure the high purity of the final product. The comprehensive application of these separation and purification technologies provides a strong guarantee for the preparation of high-purity Bose.

[0036] Specifically, the process can produce bosone with a purity of more than 99.9%, and the purity is determined by high performance liquid chromatography.

[0037] In this embodiment: In cosmetics, high-purity phosphene can greatly improve the quality of the product. Its excellent anti-aging, moisturizing, repairing and other effects can be fully exerted, bringing significant beauty effects to consumers. High purity means extremely low impurity content, reducing potential safety risks, making consumers feel more assured when using it. In the field of medicine, high-purity phosphene is used as a drug active ingredient or excipient, and its effectiveness and safety are fully guaranteed. Doctors can accurately determine the dosage according to specific symptoms and dosage forms, provide patients with more accurate treatment plans, and improve treatment effects.

[0038] Specifically, the process is repeatable and stable, and can maintain the quality of high-purity boson in different production batches.

[0039] In this embodiment, the quality of high-purity bosine can be maintained in different production batches, ensuring that each batch of products has the same high purity and excellent performance. This not only reduces production costs and improves production efficiency, but also enhances the market competitiveness of products. For cosmetics and pharmaceutical companies, repeatability and stability mean that high-quality bosine can be stably supplied to meet market demand. At the same time, it also lays a solid foundation for the long-term development of the company, establishes a good brand image, and wins the trust of consumers and customers.

[0040] Specifically, it has specific physical and chemical properties and purity indicators and can be widely used in the fields of cosmetics, medicine, etc.

[0041] In this embodiment: In the field of cosmetics, high-purity phosphene can better play its anti-aging, moisturizing, repairing and other effects, and improve the quality and market competitiveness of cosmetics. Its unique physical and chemical properties, such as good stability, solubility and permeability, can be better used in combination with other cosmetic ingredients to bring consumers a better user experience. In the field of medicine, high-purity phosphene can be used as a pharmaceutical active ingredient or excipient to treat diseases or symptoms related to skin repair and anti-aging. Its high purity ensures the effectiveness and safety of the drug, providing patients with a more effective treatment plan.

[0042] Specifically, it can be used to prepare cosmetic products with anti-aging, moisturizing, repairing and other effects, and the added amount in the cosmetics is 0.5%-5%.

[0043] In this embodiment: First, this addition amount range can give full play to the anti-aging, moisturizing, repairing and other effects of phosgene while ensuring product safety. High-purity phosgene can more effectively fight skin aging and bring significant beauty effects to consumers. Secondly, cosmetics with high-purity phosgene reduce the presence of impurities and reduce potential safety risks, making consumers feel more assured when using them. In addition, the application of high-purity phosgene can also improve the quality and brand image of cosmetics, attract more consumers to buy, and bring greater economic benefits to the company.

[0044] Specifically, it can be used as an active ingredient or excipient in medicine to treat diseases or symptoms related to skin repair and anti-aging, and the dosage in the medicine is determined according to the specific disease and dosage form.

[0045] In this embodiment: As an active ingredient of medicine, high-purity phosphene can more effectively treat diseases or symptoms related to skin repair and anti-aging. Its high purity ensures the effectiveness of the drug, and doctors can accurately determine the dosage according to the specific symptoms and dosage form, providing patients with more accurate treatment plans. As an excipient, high-purity phosphene can improve the stability and bioavailability of the drug and enhance the efficacy of the drug. At the same time, the safety of high-purity phosphene is also fully guaranteed, reducing the side effects of the drug, and providing more options for the treatment of patients.

[0046] Specifically, it has good stability during storage and transportation, and can be stably stored for more than 24 months at a temperature of 5°C-25°C and a relative humidity not exceeding 60%, and is not easy to decompose or deteriorate.

[0047] In this embodiment, under the conditions of 5°C-25°C and relative humidity not exceeding 60%, the product can be stably stored for more than 24 months without being easily decomposed or deteriorated. This greatly reduces storage and transportation costs and improves the market competitiveness of the product. For cosmetics and pharmaceutical companies, stable storage and transportation conditions can reduce product losses and waste and improve the economic benefits of the company. At the same time, it also provides consumers and patients with more reliable products and ensures product quality and safety.

[0048] The working principle and use process of the present invention:

[0049] First, raw material selection and pretreatment are carried out. Specific raw materials are carefully selected, including substance X (hydroxypropyl tetrahydropyrantriol precursor compound) with a purity of not less than 99.5%, substance Y (methyl propanediol) with a purity of not less than 99% and substance Z (propylene glycol) with a purity of not less than 98.5%. Substance X is dried at a temperature of 50°C-60°C for 2-3 hours to remove moisture. Substance Y is dissolved in a specific solvent and filtered to remove insoluble impurities to ensure its purity. Substance Z is activated under a vacuum environment for 1-2 hours to prepare the following. Prepare for the subsequent reaction, then carry out the key synthesis reaction, react in the reactor, strictly control the reaction temperature at 80℃-90℃, maintain the pressure at 0.5MPa-0.8MPa, and the reaction time is 5-6 hours. Select the appropriate A catalyst, the amount of which is 0.5%-1% of the total mass of the raw materials. Under such precisely controlled chemical reaction conditions, an intermediate product containing bosine is generated. Then, advanced separation and purification technology is used. First, chromatographic separation is used, and a specific chromatographic column is selected to separate the B solution and the C solution by volume. A mixture of 3:1 was used as the mobile phase with a flow rate controlled at 1-2 mL / min. The target product fractions were collected to effectively remove impurities in the intermediate product. Then, a crystallization treatment was performed. Crystallization was performed at a temperature of 10°C-15°C for 3-4 hours to obtain a high-purity bosonine finished product. The purity of the finished product was detected by high-performance liquid chromatography and was over 99.9%. In the cosmetics field, high-purity bosonine was used in cosmetics at an addition amount of 0.5%-5%, which greatly improved the quality of cosmetics and exerted excellent anti-aging, moisturizing, repairing and other effects while reducing potential safety risks. In the pharmaceutical field, it can be used as an active ingredient or excipient of a drug. Doctors determine the dosage according to the specific symptoms and dosage form to provide patients with precise treatment plans. During storage and transportation, as long as the temperature is kept at 5°C-25°C and the relative humidity does not exceed 60%, the high-purity bosonine can be stably stored for more than 24 months, is not easy to decompose or deteriorate, reduces costs, and improves market competitiveness. In short, the preparation process provides a reliable solution for the cosmetics and pharmaceutical industries.

[0050] Finally, it should be noted that the above are only preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A process for preparing high-purity boson, characterized in that: The following steps are involved: Step 1: Select specific raw materials, wherein the raw materials include substance X which is a hydroxypropyl tetrahydropyrantriol precursor compound, substance Y which is methyl propanediol, and substance Z which is propylene glycol. The purity of substance X is not less than 99.5%, the purity of substance Y is not less than 99%, and the purity of substance Z is not less than 98.5%. The raw materials are pretreated, substance X is dried at a temperature of 50°C-60°C for 2-3 hours; substance Y is dissolved in a specific solvent and filtered to remove insoluble impurities; substance Z is activated in a vacuum environment for 1-2 hours. Step 2: The key synthesis reaction is carried out through precisely controlled chemical reaction conditions. The reaction is carried out in a reactor. The reaction temperature is controlled at 80°C-90°C, the pressure is maintained at 0.5MPa-0.8MPa, the reaction time is 5-6 hours, and the catalyst is selected as catalyst A, and the amount used is 0.5%-1% of the total mass of the raw materials to generate an intermediate product containing bosine. Step 3: Using advanced separation and purification technology, first use chromatographic separation, select a specific chromatographic column, the mobile phase is a mixture of solution B and solution C in a volume ratio of 3:1, the flow rate is controlled at 1-2mL / min, and the target product fraction is collected. Then crystallization is performed at a temperature of 10℃-15℃ for 3-4 hours to obtain a high-purity bosine product.

2. The process for preparing high-purity bosonine according to claim 1, characterized in that: The specific raw material selection and pretreatment method includes strict screening, testing and specific physical or chemical treatment of the raw materials to remove impurities that may affect the purity of boson.

3. The process for preparing high-purity bosonine according to claim 2, characterized in that: The precisely controlled chemical reaction conditions include reaction temperature, pressure, reaction time, selection and dosage of catalyst, etc., to ensure efficient synthesis reaction and purity of the product.

4. The process for preparing high-purity bosonine according to claim 3, characterized in that: The advanced separation and purification technologies include, but are not limited to, chromatography, crystallization, membrane separation and the like, to effectively remove impurities from intermediate products and final products.

5. The advanced preparation process of high-purity boson and its wide application according to claim 4, characterized in that: The process can prepare bosogen with a purity of more than 99.9%, and the purity is determined by high performance liquid chromatography.

6. The process for preparing high-purity bosonine according to claim 5, characterized in that: The process is reproducible and stable, and can maintain the quality of high-purity bosogenin in different production batches.

7. The process for preparing high-purity bosonine according to claim 6, characterized in that: It has specific physical and chemical properties and purity indicators and can be widely used in cosmetics, medicine and other fields.

8. The high-purity boson obtained by the advanced preparation process of high-purity boson according to claim 7, characterized in that: It can be used to prepare cosmetic products with anti-aging, moisturizing, repairing and other effects, and the added amount in cosmetics is 0.5%-5%.

9. The use of high-purity bosine in the field of cosmetics according to claim 8, characterized in that: It can be used as an active ingredient or excipient in medicine to treat diseases or symptoms related to skin repair and anti-aging. The dosage in the medicine is determined according to the specific disease and dosage form.

10. A high-purity boson according to claim 9, characterized in that: It has good stability during storage and transportation. Under the conditions of temperature of 5℃-25℃ and relative humidity not exceeding 60%, it can be stably stored for more than 24 months and is not easy to decompose or deteriorate.