Biomarkers for drug-related jawbone necrosis and uses thereof

Abstract

The invention relates to the field of oral cavities, in particular to a biomarker for drug-related jawbone necrosis and application of the biomarker. The invention provides application of a biomarker to preparation of a drug-related jawbone necrosis detection product. The biomarker comprises an oral metabolite and an oral flora, the oral metabolite comprises one or a combination of more of spermine, 7-methylguanine, hypoxanthine, quinoline and taurine. And the oral flora comprises bacteria of bacteroides, peptostreptococcaceae, porphyrinomonas, butyric acid vibrio, micromonas and moniliaceae, and the oral flora comprises bacteria of bacteroides, peptostreptococcaceae, porphyrinomonas, butyric acid vibrio. According to the application, metabolite and microorganisms which are characteristic-changed in an MRONJ microenvironment are discovered, the pathogenesis that the metabolite and the microorganisms possibly participate in the MRONJ is predicted, the risk that an individual suffers from the MRONJ is expected to be judged in an early stage through oral metabolite and microorganism marker screening, occurrence of the MRONJ is prevented by adjusting a medication strategy or modifying oral flora in time, and the MRONJ is prevented from being damaged by the oral metabolite and the microorganism. Therefore, the method is of great significance to formulating a new osteoporosis clinical prevention and treatment strategy.

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