Stem cell sample incubator for biopharmacy

Abstract

The stem cell sample constant-temperature box comprises a box body, a sealing cover is hinged to one side of the top of the box body, the interior of the box body is divided into a storage cavity and a transmission cavity through a partition plate fixedly installed at the bottom, a transmission rotating shaft is rotatably installed at the center of the partition plate, and one ends of a plurality of placement plates are slidably connected to the transmission rotating shaft; the placing plate is movably arranged in the storage cavity, the other end of the placing plate is slidably connected with a plurality of guide sliding rails, the guide sliding rails are fixedly installed on the inner wall of the bottom of the storage cavity, a first dovetail sliding groove is formed in the inner wall of one side of the storage cavity, one side of a lifting assembly is slidably clamped in the first dovetail sliding groove, and the other side of the lifting assembly is slidably clamped to the other end of the placing plate; the bottom of the lifting assembly is connected with a threaded rod through a threaded structure, the threaded rod is rotationally installed in the first dovetail sliding groove, the bottom end of the threaded rod is in transmission connection with a transmission switching assembly, and the transmission switching assembly is slidably arranged on one side of the bottom of the box body.

Description

Technical Field

[0001] The invention relates to the technical field of medical devices, and in particular to a constant temperature box for stem cell samples used in biopharmaceuticals. Background Art

[0002] Biopharmaceuticals are an important pillar of the modern pharmaceutical industry. Stem cell samples are commonly used samples in the biopharmaceutical process. Stem cells are usually placed in test tubes for storage, and then the stem cell test tubes are placed in a freezing preservation device to increase the storage time of the stem cells.

[0003] A Chinese utility model patent with announcement number CN216018774U discloses a constant temperature box for stem cell samples used for biopharmaceuticals, including a constant temperature box body, the right side of which is rotatably connected to a box door via two hinges, a sliding hole is provided on the upper side of the constant temperature box body, a sliding rod is movably sleeved in the sliding hole, both ends of the sliding rod extend out of the sliding hole, a sealing plate is fixedly connected to the lower end of the sliding rod, and a first sealing ring is fixedly connected to the upper side of the sealing plate.

[0004] Although the above-mentioned prior art effectively improves the safety of stem cell sample storage in a constant temperature box and effectively improves the convenience of cleaning the constant temperature box, the preservation box must be opened when the stem cell test tubes are taken out and placed. When the preservation box is opened, the internal cold air will be released, thereby increasing the internal temperature. When it is closed, it takes a while to restore the internal temperature, which will have a certain impact on the cryopreservation of stem cells. For this reason, we propose a constant temperature box for stem cell samples used in biopharmaceuticals to solve the above problems. Summary of the invention

[0005] The object of the present invention is to provide a constant temperature box for stem cell samples used in biopharmaceuticals to solve the problems raised in the above background technology.

[0006] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: a constant temperature box for stem cell samples for biopharmaceuticals, comprising a box body, a sealing cover is hingedly connected to one side of the top of the box body, a storage chamber and a transmission chamber are separated in the box body by a partition fixedly installed at the bottom, a transmission shaft is rotatably installed at the center of the partition, one end of a plurality of placement plates is slidably connected to the transmission shaft, the placement plates are movably arranged in the storage chamber, the other end of the placement plates is slidably connected to a plurality of guide rails, the guide rails are fixedly installed on the bottom inner wall of the storage chamber, a dovetail slot is provided on the inner wall of one side of the storage chamber, one side of the dovetail slot is slidably engaged with a lifting component, and the other side of the lifting component is slidably engaged with the other end of the placement plate, the bottom of the lifting component is connected to a threaded rod through a threaded structure, the threaded rod is rotatably installed in the dovetail slot, the bottom end of the threaded rod is transmission-connected to a transmission switching component, the transmission switching component is slidably arranged on one side of the bottom of the box body, one side of the transmission switching component is movably arranged in the transmission chamber and the transmission switching component is slidably engaged with the transmission component, and the transmission component is fixedly connected to the bottom of the transmission shaft.

[0007] Preferably, the shaft body of the transmission shaft is provided with a plurality of dovetail grooves 2, the dovetail grooves 2 are located in the storage cavity, and four dovetail grooves 2 are evenly distributed around the circumference.

[0008] Preferably, four groups of placement plates are evenly distributed around the circumference and three placement plates are arranged in each group from bottom to top, and a single placement plate is penetrated with a plurality of placement holes, and both ends of a single placement plate are respectively fixedly connected to one end of the connecting part and one end of the clamping part, and the other end of the connecting part is fixedly connected with an arc-shaped bar, and the arc-shaped bar is respectively slidably clamped to two dovetail slide grooves, and the other end of the clamping part is respectively slidably clamped to the guide rail and the lifting assembly.

[0009] Preferably, the lifting assembly includes a movable cylindrical pin, an upper connecting rod 1, a long connecting rod 1, a long connecting rod 2, a lower connecting rod 1, a lower connecting rod 2, a long connecting rod 3, a long connecting rod 4, an upper connecting rod 2, and a fixed cylindrical pin, wherein the fixed cylindrical pin is fixedly connected to the bottom inner wall of the storage cavity and the fixed cylindrical pin is located at the bottom of the dovetail slide groove 1, and the fixed cylindrical pin is respectively hinged to one end of the lower connecting rod 1 and the lower connecting rod 2, the other end of the lower connecting rod 1 is hinged to one end of the long connecting rod 3, and the other end of the long connecting rod 3 is hinged to the long connecting rod One end of the long connecting rod one, the other end of the long connecting rod one is hinged to the other end of the upper connecting rod two, the other end of the upper connecting rod two is hinged to one end of the upper connecting rod one, the other end of the upper connecting rod one is hinged to one end of the long connecting rod four, the other end of the long connecting rod four is hinged to one end of the long connecting rod two, and the other end of the long connecting rod two is hinged to the other end of the lower connecting rod two, wherein the ends of the upper connecting rod one and the upper connecting rod two, the middle parts of the long connecting rod one and the long connecting rod four, and the middle parts of the long connecting rod two and the long connecting rod three are hingedly arranged by movable cylindrical pins.

[0010] Preferably, one end of the movable cylindrical pin is recessed with an insert hole, and the insert hole is slidably engaged with the end of the clamping part. The other end of the movable cylindrical pin is fixedly connected with an anti-slip slider, and the anti-slip slider at the bottom is connected to the threaded rod through a threaded structure, and the remaining anti-slip sliders are slidably sleeved on the threaded rod.

[0011] Preferably, the upper connecting rod 1, the long connecting rod 1, the long connecting rod 2 and the lower connecting rod 1 are arranged parallel to each other, the lower connecting rod 2, the long connecting rod 3, the long connecting rod 4 and the upper connecting rod 2 are arranged parallel to each other, the lengths of the long connecting rod 1, the long connecting rod 2, the long connecting rod 3 and the long connecting rod 4 are equal, the lengths of the upper connecting rod 1, the lower connecting rod 1, the lower connecting rod 2 and the upper connecting rod 2 are equal, and the length of the long connecting rod 1 is twice the length of the upper connecting rod 1.

[0012] Preferably, the transmission assembly includes a transmission part, an active part, a supporting shaft, a worm wheel, a worm, an active connecting rod, and a toggle block. The transmission part is fixedly sleeved on the bottom of the transmission shaft, one side of the transmission part slides against the active part, the active part is fixedly sleeved on the middle part of the supporting shaft, the supporting shaft is rotatably installed in the transmission cavity, one side of the supporting shaft is fixedly connected to one end of the active connecting rod, the other end of the active connecting rod is rotatably connected to the toggle block, the other side of the supporting shaft is fixedly sleeved on the worm wheel, the worm wheel is meshedly connected to the worm, the worm is rotatably installed in the transmission cavity, and the worm is slidably engaged with the transmission switching assembly.

[0013] Preferably, a plurality of limit openings are provided on the edge of the transmission part, the limit openings are arc-shaped structures and are slidably engaged with the active part, a toggle opening is provided between two adjacent limit openings, the toggle opening is slidably engaged with the toggle block, a fan-shaped opening is provided on one side edge of the active part, the active connecting rod is arranged in the middle position of the fan-shaped opening, and a second slot is provided at one end of the worm.

[0014] Preferably, the transmission switching assembly includes a handwheel, a movable shaft, a sleeve cylinder, a transmission bevel gear, and an active bevel gear. The sleeve cylinder is rotatably installed on one side of the bottom of the casing, and the movable shaft is slidably sleeved in the sleeve cylinder. One end of the movable shaft is fixedly connected to the handwheel, and the handwheel is rotatably arranged outside the casing. The other side of the movable shaft is slidably sleeved in a worm gear, and the active bevel gear is fixedly sleeved outside the sleeve cylinder. The active bevel gear is meshed and connected to the transmission bevel gear, and the transmission bevel gear is fixedly connected to the bottom end of the threaded rod. The transmission bevel gear and the active bevel gear are respectively rotatably arranged in an active cavity hollow at the bottom of the casing.

[0015] Preferably, a first card slot is formed at one end of the sleeve tube close to the worm, and a card block is fixedly sleeved outside the movable shaft. The card block is located between the sleeve tube and the worm, and the card block is slidably engaged with the first card slot and the second card slot respectively.

[0016] Compared with the prior art, the beneficial effects of the present invention are as follows: by operating the transmission switching component, the power switching of the lifting component and the transmission component can be realized respectively, and then both can be operated separately by one power source, thereby reducing the complexity of parts and components; a group of placement plates are driven by the lifting component to realize lifting and lowering, thereby facilitating the placement and taking of stem cell sample tubes on the placement plates, while the placement plates of the remaining groups are still located at the bottom of the box body, thereby preventing the remaining stem cell samples from being affected, and making the temperature change inside the box body smaller. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the structure of the present invention;

[0018] Figure 2 It is a schematic diagram of the internal structure of the box body of the present invention;

[0019] Figure 3 This is a schematic diagram of the structure of the interior of the box from a side perspective of the present invention;

[0020] Figure 4 This is a schematic diagram of the internal structure of the box body of the present invention when viewed from above;

[0021] Figure 5 It is a schematic diagram of the cross-sectional structure of the present invention;

[0022] Figure 6 For the present invention Figure 5 A schematic diagram of the structure enlargement in the middle;

[0023] Figure 7 This is a schematic diagram of the structure of the lifting assembly of the present invention after working;

[0024] Figure 8 It is a schematic diagram of the planar structure of the lifting component in the present invention.

[0025] In the figure: box 1, storage chamber 101, dovetail slide 102, transmission chamber 103, sealing cover 2, transmission switching assembly 3, hand wheel 31, movable shaft 32, sleeve 33, card slot 1331, transmission bevel gear 34, active bevel gear 35, card block 36, placement plate 4, placement hole 41, connecting part 42, arc strip 43, card connection part 44, guide rail 5, lifting assembly 6, movable cylindrical pin 60, plug hole 601, upper connecting rod 61, long connecting rod 1 62, long connecting rod 2 63, lower connecting rod 1 64, lower connecting rod 2 65, long connecting rod 3 66, long connecting rod 4 67, upper connecting rod 2 68, fixed cylindrical pin 69, transmission shaft 7, dovetail slide groove 2 71, threaded rod 8, transmission assembly 9, transmission part 91, toggle opening 911, limit opening 912, active part 92, fan-shaped opening 921, support shaft 93, worm wheel 94, worm 95, slot 2 951, active connecting rod 96, toggle block 97, partition 10. DETAILED DESCRIPTION

[0026] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0027] Example 1

[0028] Reference Figure 1-8 , which is the first embodiment of the present invention, and provides a constant temperature box for stem cell samples for biopharmaceuticals, including a box body 1, a sealing cover 2 is hingedly connected to one side of the top of the box body 1, and a storage chamber 101 and a transmission chamber 103 are separated in the box body 1 by a partition 10 fixedly installed at the bottom, and a transmission shaft 7 is rotatably installed at the center of the partition 10, and one end of a plurality of placement plates 4 is slidably connected to the transmission shaft 7, and the placement plates 4 are movably arranged in the storage chamber 101, and the other end of the placement plates 4 is slidably connected to a plurality of guide rails 5, and the guide rails 5 are fixedly installed on the bottom inner wall of the storage chamber 101, and the storage chamber 101 A dovetail groove 102 is provided on the inner wall of one side, and one side of the lifting component 6 is slidably engaged in the dovetail groove 102, and the other side of the lifting component 6 is slidably engaged in the other end of the placement plate 4. The bottom of the lifting component 6 is connected to the threaded rod 8 through a threaded structure, and the threaded rod 8 is rotatably installed in the dovetail groove 102. The bottom end of the threaded rod 8 is transmission-connected to the transmission switching component 3, and the transmission switching component 3 is slidingly arranged on one side of the bottom of the box body 1. One side of the transmission switching component 3 is movably arranged in the transmission cavity 103 and the transmission switching component 3 is slidably engaged with the transmission component 9, and the transmission component 9 is fixedly connected to the bottom of the transmission shaft 7.

[0029] The box body 1 is filled with liquid nitrogen or a constant temperature box body in the prior art is used to store stem cell samples placed in the box body 1. A handle is fixedly installed on the top of the sealing cover 2 to facilitate the opening and closing operation of the sealing cover 2. At the same time, a lock is arranged on the sealing cover 2 and the box body 1 to lock and close the sealing cover 2. A circular opening is opened on the top of the box body 1, and the circular opening is closed by the sealing cover 2. When in use, the sealing cover 2 is opened, and the transmission switching component 3 is operated. The transmission switching component 3 cooperates with the threaded rod 8. The transmission switching component 3 is manually operated to drive the threaded rod 8 to rotate. The threaded rod 8 drives the lifting component 6 to work through the threaded structure, and then through the cooperation of various components, a group of placement plates 4 are driven to be lifted in sequence. After the placement plates 4 are lifted to the top, a shape as shown in the figure is formed. Figure 7In the structure shown, the placement plate 4 protrudes from the circular opening at the top of the box body 1, and then the stem cell sample tubes are respectively placed in the placement holes 41, the placement holes 41 of the top placement plate 4 are interference fit with the test tubes, and the test tubes are limited and fixed, and the two placement plates 4 at the bottom support and limit the test tubes. After the placement of this group of placement plates 4 is completed, the transmission switching component 3 is rotated in the opposite direction to drive the lifting component 6 to descend, and the lifting component 6 drives the placement plate 4 to descend, and the placement plate 4 then drives the test tube to be stored at the bottom of the box body 1, and then the transmission switching component 3 is pushed, and the transmission switching component 3 is engaged with the transmission component 9, and the transmission switching component 3 is operated to drive the transmission component 9 to work , the transmission component 9 drives the placement plate 4 to rotate synchronously by 90 degrees, and the placement plate 4 moves from the guide slide rail 5 of the annular structure to the position of the lifting component 6, and then the rectangular card block is separated from the guide slide rail 5 and inserted into the plug hole 601, so that a new group of placement plates 4 are placed in the stem cell sample tube. After the tube is placed, the sealing cover 2 is closed to seal the box 1, and the lifting component 6 drives a group of placement plates 4 to be lifted and lowered, so as to facilitate the placement and removal of the stem cell sample tube on the placement plate 4. At the same time, the placement plates 4 of the remaining groups are still located at the bottom of the box 1 to avoid the remaining stem cell samples from being affected, so that the temperature change inside the box 1 is small.

[0030] Example 2

[0031] Reference Figure 1-8 , which is the second embodiment of the present invention, and this embodiment is based on the previous embodiment. Specifically, the shaft body of the transmission shaft 7 is provided with a plurality of dovetail grooves 71, and the dovetail grooves 71 are located in the storage cavity 101. Four dovetail grooves 71 are evenly distributed around the circumference. The setting of the dovetail grooves 71 facilitates the support for the lifting and lowering of the placement plate 4.

[0032] Specifically, four groups of placement plates 4 are evenly distributed on the circumference with the transmission shaft 7 as the center, and three placement plates 4 are arranged in each group from bottom to top. A single placement plate 4 is penetrated by a plurality of placement holes 41, and the placement holes 41 on each group of placement plates 4 are arranged one by one. The two ends of a single placement plate 4 are respectively fixedly connected to one end of the connecting part 42 and one end of the clamping part 44, and the other end of the connecting part 42 is fixedly connected with an arc strip 43, and the arc strip 43 is respectively slidably clamped to the dovetail slide groove 71, and the other end of the clamping part 44 is respectively slidably clamped to the guide rail 5 and the lifting assembly 6.

[0033] When inserting the stem cell sample tube, the placement plate 4 protrudes from the circular opening at the top of the box body 1, and then the stem cell sample tube is inserted into the placement holes 41 respectively. The placement holes 41 of the top placement plate 4 are interference fit with the test tube to limit and fix the test tube, and the two bottom placement plates 4 support and limit the test tube.

[0034] Specifically, the lifting assembly 6 includes a movable cylindrical pin 60, an upper connecting rod 1 61, a long connecting rod 1 62, a long connecting rod 2 63, a lower connecting rod 1 64, a lower connecting rod 2 65, a long connecting rod 3 66, a long connecting rod 4 67, an upper connecting rod 2 68, and a fixed cylindrical pin 69. The fixed cylindrical pin 69 is fixedly connected to the bottom inner wall of the storage cavity 101 and is located at the bottom of the dovetail slide 1 102. The fixed cylindrical pin 69 is respectively hinged to one end of the lower connecting rod 1 64 and the lower connecting rod 2 65. The other end of the lower connecting rod 1 64 is hinged to one end of the long connecting rod 3 66. The other end of the long connecting rod 3 66 is hinged to the bottom inner wall of the storage cavity 101. One end of the long link 62 is connected, the other end of the long link 62 is hinged to the other end of the upper link 68, the other end of the upper link 68 is hinged to one end of the upper link 61, the other end of the upper link 61 is hinged to one end of the long link four 67, the other end of the long link four 67 is hinged to one end of the long link two 63, and the other end of the long link two 63 is hinged to the other end of the lower link two 65, wherein the ends of the upper link 61 and the upper link two 68, the middle parts of the long link 62 and the long link four 67, and the middle parts of the long link two 63 and the long link three 66 are hingedly arranged by a movable cylindrical pin 60.

[0035] Furthermore, one end of the movable cylindrical pin 60 is recessed with an insert hole 601, and the insert hole 601 is slidably engaged with the end of the clamping portion 44. The other end of the movable cylindrical pin 60 is fixedly connected with an anti-slip slider, and the anti-slip slider at the bottom is connected to the threaded rod 8 through a threaded structure, and the remaining anti-slip sliders are slidably sleeved on the threaded rod 8.

[0036] Furthermore, the upper connecting rod 61, the long connecting rod 1 62, the long connecting rod 2 63 and the lower connecting rod 1 64 are arranged parallel to each other, the lower connecting rod 2 65, the long connecting rod 3 66, the long connecting rod 4 67 and the upper connecting rod 2 68 are arranged parallel to each other, the lengths of the long connecting rod 1 62, the long connecting rod 2 63, the long connecting rod 3 66 and the long connecting rod 4 67 are equal, the lengths of the upper connecting rod 1 61, the lower connecting rod 1 64, the lower connecting rod 2 65 and the upper connecting rod 2 68 are equal, and the length of the long connecting rod 1 62 is twice the length of the upper connecting rod 1 61.

[0037] The threaded rod 8 drives the lifting assembly 6 to work through the threaded structure, and the anti-slip slider located at the bottom is threadedly matched with the threaded rod 8, and then through the cooperation of various components, the movable cylindrical pins 60 are driven to lift up in sequence, and the movable cylindrical pins 60 drive a group of clamped placement plates 4 to lift up in sequence, and the end of the clamping part 44 slides to clamp the rectangular clamping block, and the rectangular clamping block is fixed with a spring, which is movably arranged inside the clamping part 44. Through the elastic force of the spring, the rectangular clamping block is clamped into the plug-in hole 601, and the placement plate 4 is lifted to the top to form a Figure 7In the structure shown, the placement plate 4 protrudes from the circular opening at the top of the box body 1, and then the stem cell sample tubes are respectively placed in the placement holes 41. The placement holes 41 of the top placement plate 4 are interference fit with the test tubes to limit and fix the test tubes. The two bottom placement plates 4 support and limit the test tubes. After the placement of this group of placement plates 4 is completed, the hand wheel 31 is rotated in the opposite direction to drive the lifting assembly 6 to descend. The lifting assembly 6 drives the placement plate 4 to descend, and the placement plate 4 then drives the test tubes to be stored at the bottom of the box body 1.

[0038] Specifically, the transmission assembly 9 includes a transmission part 91, an active part 92, a supporting shaft 93, a worm wheel 94, a worm 95, an active connecting rod 96, and a toggle block 97. The transmission part 91 is fixedly sleeved on the bottom of the transmission shaft 7, one side of the transmission part 91 slides against the active part 92, the active part 92 is fixedly sleeved on the middle part of the supporting shaft 93, the supporting shaft 93 is rotatably installed in the transmission cavity 103, one side of the supporting shaft 93 is fixedly connected to one end of the active connecting rod 96, the other end of the active connecting rod 96 is rotatably connected to the toggle block 97, the other side of the supporting shaft 93 is fixedly sleeved on the worm wheel 94, the worm wheel 94 is meshedly connected to the worm 95, the worm 95 is rotatably installed in the transmission cavity 103, and the worm 95 slides and engages with the transmission switching assembly 3.

[0039] Furthermore, a plurality of limit openings 912 are provided on the edge of the transmission part 91. The limit openings 912 are arc-shaped structures and are slidably engaged with the active part 92. A toggle opening 911 is provided between two adjacent limit openings 912. The toggle opening 911 is slidably engaged with the toggle block 97. A fan-shaped opening 921 is provided on one side edge of the active part 92. The active connecting rod 96 is arranged in the middle position of the fan-shaped opening 921. A slot 2 951 is provided at one end of the worm gear 95.

[0040] Furthermore, the transmission switching assembly 3 includes a handwheel 31, a movable shaft 32, a sleeve tube 33, a transmission bevel gear 34, and an active bevel gear 35. The sleeve tube 33 is rotatably installed on one side of the bottom of the housing 1, and the movable shaft 32 is slidably sleeved in the sleeve tube 33. One end of the movable shaft 32 is fixedly connected to the handwheel 31. The handwheel 31 is rotatably arranged outside the housing 1, and the other side of the movable shaft 32 is slidably sleeved in the worm 95. The active bevel gear 35 is fixedly sleeved outside the sleeve tube 33, and the active bevel gear 35 is meshed and connected to the transmission bevel gear 34. The transmission bevel gear 34 is fixedly connected to the bottom end of the threaded rod 8, and the transmission bevel gear 34 and the active bevel gear 35 are respectively rotatably arranged in the hollow movable cavity at the bottom of the housing 1.

[0041] Furthermore, a slot 1 331 is formed at one end of the sleeve 33 close to the worm 95 , and a block 36 is fixedly sleeved on the outside of the movable shaft 32 . The block 36 is located between the sleeve 33 and the worm 95 , and the block 36 is slidably engaged with the slot 1 331 and the slot 2 951 .

[0042] To operate the transmission switching assembly 3, manually pull the handwheel 31 to drive the movable shaft 32 to move, and the movable shaft 32 drives the fixed block 36 to move, and the block 36 is engaged with the first slot 331, and then turn the handwheel 31 to drive the movable shaft 32 to rotate, and the movable shaft 32 drives the engaged sleeve tube 33 to rotate, and the sleeve tube 33 drives the fixed active bevel gear 35 to rotate, and the active bevel gear 35 drives the meshing transmission bevel gear 34 to rotate, and the transmission bevel gear 34 drives the fixed threaded rod 8 to rotate, and the threaded rod 8 drives the lifting assembly 6 to work through the threaded structure; push the handwheel 31 of the transmission switching assembly 3 to drive the movable shaft 32 to move, and the movable shaft 32 drives the block 36 to engage with the second slot 951, and then turn the handwheel 31 to drive the movable shaft 32 to rotate, and the movable shaft 32 drives the worm 95 of the transmission assembly 9 to rotate, thereby realizing the operation of the transmission assembly 9.

[0043] The hand wheel 31 is turned to drive the movable shaft 32 to rotate, and the movable shaft 32 drives the worm 95 of the transmission assembly 9 to rotate, the worm 95 drives the worm wheel 94 to rotate, the worm wheel 94 drives the supporting shaft 93 to rotate, the supporting shaft 93 drives the active connecting rod 96 to rotate, the active connecting rod 96 drives the toggle block 97 to rotate in a circle, the toggle block 97 cooperates with the toggle opening 911 to drive the transmission part 91 to rotate 90 degrees, the transmission part 91 drives the transmission shaft 7 to rotate 90 degrees, the transmission shaft 7 then drives the arc bar 43 to rotate synchronously, the arc bar 43 drives the placement plate 4 to rotate synchronously, the placement plate 4 rotates from the guide rail 5 of the annular structure to the lifting assembly 6 position, and then the rectangular block is separated from the guide rail 5 and inserted into the plug hole 601, so that a new group of placement plates 4 can be placed in the stem cell sample tube.

[0044] Example 3

[0045] Reference Figure 1-8, which is the third embodiment of the present invention. This embodiment is based on the above two embodiments. Liquid nitrogen is filled into the box body 1 or a constant temperature box body in the prior art is used to store the stem cell samples placed in the box body 1. A handle is fixedly installed on the top of the sealing cover 2 to facilitate the opening and closing operation of the sealing cover 2. At the same time, a lock is arranged on the sealing cover 2 and the box body 1 to lock and close the sealing cover 2. A circular opening is opened on the top of the box body 1, and the circular opening is closed by the sealing cover 2. When in use, the sealing cover 2 is opened, the transmission switching component 3 is operated, the hand wheel 31 is manually pulled to drive the movable shaft 32 to move, and the movable shaft 32 drives the fixed block 36 to move, and the block 36 is engaged with the card slot 1 331, and then the hand wheel 31 is rotated to drive the movable shaft 32 to rotate, and the movable shaft 32 is driven to move. The movable shaft 32 drives the connected sleeve tube 33 to rotate, the sleeve tube 33 drives the fixed active bevel gear 35 to rotate, the active bevel gear 35 drives the meshing transmission bevel gear 34 to rotate, the transmission bevel gear 34 drives the fixed threaded rod 8 to rotate, the threaded rod 8 drives the lifting assembly 6 to work through the threaded structure, the anti-slip slider located at the bottom is threadedly matched with the threaded rod 8, and then through the cooperation of various components, the movable cylindrical pins 60 are driven to lift in sequence, and the movable cylindrical pins 60 drive a group of connected placement plates 4 to lift in sequence, the end of the clamping part 44 slides and clamps the rectangular clamping block, and the rectangular clamping block is fixed with a spring, the spring is movably arranged inside the clamping part 44, and the rectangular clamping block is clamped into the plug-in hole 601 through the elastic force of the spring, and the placement plate 4 is lifted to the top to form a position as shown in the figure. Figure 7In the structure shown, the placement plate 4 protrudes from the circular opening at the top of the box body 1, and then the stem cell sample tubes are respectively placed in the placement holes 41, the placement holes 41 of the top placement plate 4 are interference fit with the test tubes, and the test tubes are limited and fixed, and the two placement plates 4 at the bottom support and limit the test tubes. After the placement of this group of placement plates 4 is completed, the hand wheel 31 is rotated in the opposite direction to drive the lifting assembly 6 to descend, and the lifting assembly 6 drives the placement plate 4 to descend, and the placement plate 4 then drives the test tube to be stored at the bottom of the box body 1, and then the hand wheel 31 of the transmission switching assembly 3 is pushed to drive the movable shaft 32 to move, and the movable shaft 32 drives the clamping block 36 to engage with the second clamping slot 951, and then the hand wheel 31 is rotated to drive the movable shaft 32 to rotate, and the movable shaft 32 drives the worm 95 of the transmission assembly 9 to rotate, and the worm 95 drives the worm wheel 94 to rotate, and the worm wheel 94 drives the supporting shaft 93 to rotate, and the supporting shaft 93 drives the active connecting rod 96 Rotate, the active connecting rod 96 drives the toggle block 97 to rotate in a circle, the toggle block 97 cooperates with the toggle mouth 911, drives the transmission part 91 to rotate 90 degrees, the transmission part 91 drives the transmission shaft 7 to rotate 90 degrees, the transmission shaft 7 then drives the arc strip 43 to rotate synchronously, the arc strip 43 drives the placement plate 4 to rotate synchronously, the placement plate 4 is transferred from the guide rail 5 of the annular structure to the position of the lifting component 6, and then the rectangular card block is separated from the guide rail 5 and inserted into the plug hole 601, so that a new group of placement plates 4 are placed in the stem cell sample tube. After the test tube is placed, the sealing cover 2 is closed to seal the box 1, and a group of placement plates 4 are driven by the lifting component 6 to achieve lifting, so as to facilitate the placement of the stem cell sample tube on the placement plate 4. At the same time, the placement plates 4 of the remaining groups are still located at the bottom of the box 1 to avoid the remaining stem cell samples from being affected, so that the temperature change inside the box 1 is small.

[0046] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A constant temperature box for stem cell samples used in biopharmaceuticals, comprising a box body (1), a sealing cover (2) being hingedly connected to one side of the top of the box body (1), characterized in that: The box body (1) is divided into a storage chamber (101) and a transmission chamber (103) by a partition (10) fixedly installed at the bottom. A transmission shaft (7) is rotatably installed at the center of the partition (10). One end of a plurality of placement plates (4) is slidably connected to the transmission shaft (7). The placement plates (4) are movably arranged in the storage chamber (101). The other end of the placement plates (4) is slidably connected to a plurality of guide rails (5). The guide rails (5) are fixedly installed on the bottom inner wall of the storage chamber (101). A dovetail slide groove (102) is provided on one inner wall of the storage chamber (101). A sliding engagement is provided in the dovetail slide groove (102). One side of the lifting component (6), the other side of the lifting component (6) is slidably engaged with the other end of the placement plate (4), the bottom of the lifting component (6) is connected to a threaded rod (8) through a threaded structure, the threaded rod (8) is rotatably installed in a dovetail slide groove (102), the bottom end of the threaded rod (8) is transmission-connected to a transmission switching component (3), the transmission switching component (3) is slidably arranged on one side of the bottom of the box body (1), one side of the transmission switching component (3) is movably arranged in the transmission cavity (103) and the transmission switching component (3) is slidably engaged with a transmission component (9), and the transmission component (9) is fixedly connected to the bottom of the transmission shaft (7).

2. The stem cell sample incubator for biopharmaceuticals according to claim 1, characterized in that: The shaft body of the transmission shaft (7) is provided with a plurality of dovetail slide grooves (71), the dovetail slide grooves (71) are located in the storage cavity (101), and four dovetail slide grooves (71) are evenly distributed around the circumference.

3. The stem cell sample incubator for biopharmaceuticals according to claim 2, characterized in that: The placement plates (4) are evenly distributed in four groups around the circumference, and each group of placement plates (4) has three placement plates (4) arranged from bottom to top. A plurality of placement holes (41) are penetrated on each of the placement plates (4). The two ends of each of the placement plates (4) are respectively fixedly connected to one end of the connecting portion (42) and one end of the clamping portion (44). The other end of the connecting portion (42) is fixedly connected to an arc strip (43). The arc strip (43) is respectively slidably clamped to the second dovetail slide groove (71). The other end of the clamping portion (44) is respectively slidably clamped to the guide rail (5) and the lifting assembly (6).

4. The stem cell sample incubator for biopharmaceuticals according to claim 3, characterized in that: The lifting assembly (6) comprises a movable cylindrical pin (60), an upper connecting rod 1 (61), a long connecting rod 1 (62), a long connecting rod 2 (63), a lower connecting rod 1 (64), a lower connecting rod 2 (65), a long connecting rod 3 (66), a long connecting rod 4 (67), an upper connecting rod 2 (68), and a fixed cylindrical pin (69). The fixed cylindrical pin (69) is fixedly connected to the bottom inner wall of the storage cavity (101) and the fixed cylindrical pin (69) is located at the bottom of the dovetail slide groove 1 (102). The fixed cylindrical pin (69) is respectively hinged to one end of the lower connecting rod 1 (64) and the lower connecting rod 2 (65). The other end of the lower connecting rod 1 (64) is hinged to one end of the long connecting rod 3 (66). The other end of the long connecting rod 3 (66) is hinged to one end of the storage cavity (101). One end of the long connecting rod 1 (62) is hinged, the other end of the long connecting rod 1 (62) is hinged to the other end of the upper connecting rod 2 (68), the other end of the upper connecting rod 2 (68) is hinged to one end of the upper connecting rod 1 (61), the other end of the upper connecting rod 1 (61) is hinged to one end of the long connecting rod 4 (67), the other end of the long connecting rod 4 (67) is hinged to one end of the long connecting rod 2 (63), and the other end of the long connecting rod 2 (63) is hinged to the other end of the lower connecting rod 2 (65), wherein the ends of the upper connecting rod 1 (61) and the upper connecting rod 2 (68), the middle parts of the long connecting rod 1 (62) and the long connecting rod 4 (67), and the middle parts of the long connecting rod 2 (63) and the long connecting rod 3 (66) are hingedly arranged by a movable cylindrical pin (60).

5. The stem cell sample incubator for biopharmaceuticals according to claim 4, characterized in that: One end of the movable cylindrical pin (60) is recessed with an inserting hole (601), and the inserting hole (601) is slidably engaged with the end of the clamping portion (44). The other end of the movable cylindrical pin (60) is fixedly connected with an anti-slipping slider, and the anti-slipping slider at the bottom is connected to the threaded rod (8) through a threaded structure, and the remaining anti-slipping sliders are slidably sleeved on the threaded rod (8).

6. The stem cell sample incubator for biopharmaceuticals according to claim 5, characterized in that: The upper connecting rod 1 (61), the long connecting rod 1 (62), the long connecting rod 2 (63) and the lower connecting rod 1 (64) are arranged parallel to each other; the lower connecting rod 2 (65), the long connecting rod 3 (66), the long connecting rod 4 (67) and the upper connecting rod 2 (68) are arranged parallel to each other; the lengths of the long connecting rod 1 (62), the long connecting rod 2 (63), the long connecting rod 3 (66) and the long connecting rod 4 (67) are equal; the lengths of the upper connecting rod 1 (61), the lower connecting rod 1 (64), the lower connecting rod 2 (65) and the upper connecting rod 2 (68) are equal; the length of the long connecting rod 1 (62) is twice the length of the upper connecting rod 1 (61).

7. The stem cell sample incubator for biopharmaceuticals according to claim 1, characterized in that: The transmission assembly (9) comprises a transmission part (91), an active part (92), a supporting shaft (93), a worm wheel (94), a worm (95), an active connecting rod (96), and a toggle block (97). The transmission part (91) is fixedly sleeved on the bottom of the transmission shaft (7), one side of the transmission part (91) slides against the active part (92), the active part (92) is fixedly sleeved on the middle part of the supporting shaft (93), the supporting shaft (93) is rotatably mounted in the transmission cavity (103), one side of the supporting shaft (93) is fixedly connected to one end of the active connecting rod (96), the other end of the active connecting rod (96) is rotatably connected to the toggle block (97), the other side of the supporting shaft (93) is fixedly sleeved on the worm wheel (94), the worm wheel (94) is meshedly connected to the worm (95), the worm (95) is rotatably mounted in the transmission cavity (103), and the worm (95) is slidably engaged with the transmission switching assembly (3).

8. The stem cell sample incubator for biopharmaceuticals according to claim 7, characterized in that: The edge of the transmission part (91) is provided with a plurality of limiting openings (912), the limiting openings (912) are of an arc-shaped structure and the limiting openings (912) are slidably contacted with the active part (92), a shifting opening (911) is provided between two adjacent limiting openings (912), the shifting opening (911) is slidably sleeved with a shifting block (97), a fan-shaped opening (921) is provided on one side edge of the active part (92), the active connecting rod (96) is arranged in the middle of the fan-shaped opening (921), and a second clamping groove (951) is provided at one end of the worm (95).

9. The stem cell sample incubator for biopharmaceuticals according to claim 8, characterized in that: The transmission switching assembly (3) comprises a hand wheel (31), a movable shaft (32), a sleeve (33), a transmission bevel gear (34), and an active bevel gear (35). The sleeve (33) is rotatably mounted on one side of the bottom of the housing (1). The movable shaft (32) is slidably sleeved inside the sleeve (33). One end of the movable shaft (32) is fixedly connected to the hand wheel (31). The hand wheel (31) is rotatably arranged outside the housing (1). The other side of the movable shaft (32) is slidably sleeved to a worm (95). The active bevel gear (35) is fixedly sleeved outside the sleeve (33). The active bevel gear (35) is meshedly connected to the transmission bevel gear (34). The transmission bevel gear (34) is fixedly connected to the bottom end of the threaded rod (8). The transmission bevel gear (34) and the active bevel gear (35) are rotatably arranged in an active cavity hollow at the bottom of the housing (1).

10. The stem cell sample constant temperature box for biopharmaceuticals according to claim 9, characterized in that: A first clamping groove (331) is provided at one end of the sleeve tube (33) close to the worm (95); a clamping block (36) is fixedly sleeved outside the movable shaft (32); the clamping block (36) is located between the sleeve tube (33) and the worm (95); and the clamping block (36) is slidably clamped with the first clamping groove (331) and the second clamping groove (951) respectively.

Images