Composition with melanin inhibiting and anti-aging effects and application thereof

Abstract

The invention discloses a composition with melanin inhibiting and anti-aging effects and application thereof. The composition is prepared from the following components: nano zinc oxide, calamine, sodium ascorbyl phosphate, tocopheryl acetate, a polypeptide compound and coenzyme. By reducing the influence of exogenous factors, the generation of melanin is inhibited, free radicals in the body are removed in time, the polypeptide and NAD + coenzyme which have the function of improving the skin are supplemented, and the anti-aging effect is very good. The raw materials provided by the invention are environment-friendly and healthy, have no toxic or side effects and no dependence, can be used for a long time, have better effects on inhibiting skin melanin and resisting skin aging, and can be used independently or used in cooperation with other skin care products as an emulsion, a solution, a paste, a gel or a spray.

Description

Technical Field

[0001] The present application relates to the technical field of cosmetics, and in particular to a composition having melanin inhibition and anti-aging effects and its application. Background Art

[0002] As we all know, skin aging is a multi-step biological process, which is the result of the combined effects of endogenous physiological factors and exogenous environmental factors. Endogenous factors are mainly determined by genetics and are an aging process that occurs over time, mainly related to genes, age, hormones, etc. Exogenous factors mainly come from the adverse effects of environmental factors, including ultraviolet radiation, visible light radiation, ambient temperature, smoking, air pollution, etc.

[0003] The characteristics of the endogenous skin aging process are mainly functional changes rather than morphological changes. During this process, the skin gradually becomes dry and pale, and small fine lines appear. The characteristics of the exogenous skin aging process are obvious morphological and physiological changes, such as the appearance of rough wrinkles, decreased skin elasticity and pigmentation, etc., and further accelerate the aging of the skin. Among them, sunlight radiation is the most important factor causing skin aging. Sunlight exposure and the human body's own mitochondrial respiratory chain produce excessive free radicals. Free radicals act on the enzyme system in the human body, causing the release of collagenase and elastase. These enzymes act on the collagen and elastin in the skin and cause these two proteins to be excessively cross-linked and degraded. As a result, the skin loses elasticity, becomes loose and weak, and even wrinkles and vesicles appear. It also activates the proliferation of epidermal melanocytes, enhances the dopamine response, and causes excessive pigment deposition in the illuminated area. Long-term light exposure can cause various biochemical changes in skin cells, damage skin cells, reduce skin immune function, and lead to various benign and malignant skin tumors.

[0004] Therefore, it is necessary to provide a product that can inhibit the production of melanin by reducing the influence of exogenous factors, remove free radicals in the body in a timely manner, further supplement active substances that improve skin function, and better play an anti-aging effect on the skin. Summary of the invention

[0005] In order to solve the above problems, the present invention provides a composition with melanin inhibition and anti-aging effects and its application. The present invention selects nano zinc oxide, calamine, ascorbyl phosphate, tocopherol acetate, nicotinamide adenine dinucleotide (hereinafter referred to as NAD + The multifunctional nanoemulsion is mixed with coenzyme) and polypeptide complexes to form a multifunctional nanoemulsion with the effect of inhibiting melanin production and anti-aging. The multifunctional nanoemulsion can greatly increase the transdermal absorption capacity of the functional substances through the solubilization of the core oil phase and surfactant, inhibit the activity of tyrosinase, inhibit the formation of melanin, and restore melanin to colorless, thereby achieving the effect of whitening the skin. At the same time, the polypeptide and NAD+ The coenzyme complex provides energy for cell differentiation, promotes cell proliferation, is beneficial to skin metabolism, and has anti-wrinkle and anti-aging functions.

[0006] To achieve the above object, the present invention provides a composition with melanin inhibition and anti-aging effects, the components of which include: nano zinc oxide, calamine, sodium ascorbyl phosphate, tocopherol acetate, polypeptide complex and coenzyme.

[0007] Optionally, the composition comprises, by weight, 0.05-2 parts of nano zinc oxide, 1-10 parts of calamine, 0.1-2 parts of sodium ascorbyl phosphate, 0.05-2 parts of tocopherol acetate, 0.013-0.89 parts of polypeptide complex, and 0.05-2 parts of coenzyme.

[0008] Preferably, the composition comprises, by weight, 0.1-1 parts of nano zinc oxide, 3-8 parts of calamine, 0.5-1.5 parts of sodium ascorbyl phosphate, 0.1-1 parts of tocopherol acetate, 0.06-0.64 parts of polypeptide complex, and 0.1-1 parts of coenzyme;

[0009] Preferably, the composition comprises, by weight, 0.4 parts of nano zinc oxide, 5 parts of calamine, 1 part of sodium ascorbyl phosphate, 0.5 parts of tocopherol acetate, 0.5175 parts of polypeptide complex, and 0.5 parts of coenzyme.

[0010] Optionally, the polypeptide complex comprises, by weight, 0.001-0.05 parts of nonapeptide-1, 0.001-0.02 parts of palmitoyl tripeptide-1, 0.001-0.02 parts of palmitoyl tetrapeptide-7 and 0.01-0.8 parts of glutathione;

[0011] Preferably, the polypeptide complex comprises, by weight, 0.005-0.02 parts of nonapeptide-1, 0.003-0.01 parts of palmitoyl tripeptide-1, 0.002-0.01 parts of palmitoyl tetrapeptide-7 and 0.05-0.6 parts of glutathione.

[0012] Preferably, the polypeptide complex comprises, by weight, 0.01 parts of nonapeptide-1, 0.005 parts of palmitoyl tripeptide-1, 0.0025 parts of palmitoyl tetrapeptide-7 and 0.5 parts of glutathione.

[0013] Optionally, the coenzyme is any one of nicotinamide adenine dinucleotide and nicotinamide mononucleotide;

[0014] Preferably, the coenzyme is nicotinamide adenine dinucleotide.

[0015] The present invention also provides a method for preparing an emulsion having melanin inhibition and anti-aging effects, the method comprising the following steps:

[0016] S1. Stirring the oil-soluble silicone oil, the humectant and the thickener to obtain phase A;

[0017] S2. Stir nano zinc oxide, calamine, coenzyme, sodium ascorbyl phosphate, carbomer, triethanolamine and water to obtain phase B;

[0018] S3. stirring the tocopherol acetate, the polypeptide complex, and the emulsifier to obtain phase C;

[0019] S4. Mix phases A, B and C to obtain a composite.

[0020] Optionally, in step S1, the oil-soluble silicone oil is composed of at least one of phenyl trimethylsiloxane and polydimethylsiloxane; the moisturizer is composed of at least one of hyaluronic acid and sodium hyaluronate; and the thickener is acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer.

[0021] Optionally, in step S4, the pH value of the composition is adjusted to 7.6 using a pH adjuster, and the mixture is mixed in a water bath at 40° C. for 30 minutes to obtain the mixture.

[0022] The present invention also provides the use of any of the above-mentioned compositions in cosmetics, health products, and medicines, wherein the use includes the composition being made into an emulsion, solution, paste, gel, or spray formulation.

[0023] The synergistic effect mechanism between the components in this application:

[0024] The nano zinc oxide in this application is an astringent drug that has mild antibacterial, oil absorption, astringent, moisturizing and protective effects on the skin. It can treat symptoms such as eczema and skin itching. In addition, nano zinc oxide has ultraviolet shielding ability and can effectively resist long-wave ultraviolet rays (UVA) and medium-wave ultraviolet rays (UVB).

[0025] The main component of calamine in this application is zinc carbonate (ZnCO3), which is widely used in dermatology as a moderate antiseptic, astringent, and protective agent to treat skin inflammation or surface trauma. The calamine used in this application can help calm, soothe, and repair damaged skin, and at the same time improve the skin's glossiness through the principle of light reflection, and has the effect of correcting skin color in terms of efficacy and appearance.

[0026] The sodium ascorbyl phosphate in the present application has the functions of promoting collagen production, blocking melanin synthesis, scavenging free radicals, and preventing skin aging.

[0027] The tocopherol acetate in the present application has a good antioxidant effect in cosmetics. The tocopherol acetate in the present application is a good nutrient moisturizer for the skin, which can maintain skin moisture and make the skin soft to the touch, promote wound healing, prevent inflammation, prevent skin roughness and cracking, and improve skin dark spots.

[0028] The polypeptide complex used in the present application includes nonapeptide-1, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7 and glutathione, among which nonapeptide-1 can reduce the formation of melanin by inhibiting melanocyte-stimulating hormone, thereby achieving the effect of whitening the skin; palmitoyl tripeptide-1 is a signal peptide that can regulate the expression of wound healing proteins and produce more skin repair proteins and collagen; palmitoyl tetrapeptide-7 is a messenger peptide that can promote the synthesis of collagen and elastin; Glutathione is a tripeptide containing thiol groups, which is a combination of glutamic acid, cysteine ​​and glycine, and can scavenge free radicals, and has antioxidant and integrated detoxification effects.

[0029] NAD in this application + On the one hand, coenzymes can effectively activate DNA repair enzymes, effectively prevent skin aging and reduce wrinkles. On the other hand, they can also activate "glutathione", inhibit melanin production, reduce pigmentation, and avoid skin keratinization and skin cancer caused by UV and light.

[0030] The beneficial effects of the present invention include but are not limited to:

[0031] 1. The present invention uses nano zinc oxide, calamine, ascorbyl phosphate, tocopherol acetate, nonapeptide-1, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7 and glutathione with NAD + The coenzyme mixed system, including sodium ascorbyl phosphate and tocopherol acetate, can easily penetrate into the skin base, effectively fight free radicals, prevent melanocytes from being stimulated by free radicals and become excited, and can also reduce dopaquinone to further reduce the production of melanin; nonapeptide-1 competitively binds to melanocortin receptor 1 (hereinafter referred to as MC1R receptor) to prevent tyrosinase from being further activated to produce melanin; glutathione can effectively capture hydroxyl free radicals, single oxygen and hydrogen peroxide free radicals, thereby achieving the purpose of scavenging free radicals and inhibiting Liposome oxidation can stably protect cell membranes, inhibit the glycosylation of structural proteins, and protect collagen and elastin; the combination of palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7 can promote the synthesis of collagen and glucosamine in fibroblasts, strengthen connective tissue, increase skin firmness, promote cell activity, replenish collagen for the skin, enhance its elasticity, and reduce wrinkles; the mixture of nano zinc oxide and calamine can resist UVA and UVB, and has both smooth and moisturizing effects and antibacterial and anti-inflammatory effects while highly controlling oil; NAD +Coenzyme activates DNA repair enzymes, effectively preventing skin aging and reducing wrinkles. It can also activate "glutathione", inhibit melanin production and reduce pigmentation.

[0032] 2. The present invention can inhibit the activity of tyrosinase, inhibit the formation of melanin, and restore melanin to colorless, thereby achieving the effect of whitening the skin; the present invention uses polypeptides and NAD + The coenzyme compound provides energy for cell differentiation, promotes cell proliferation, is beneficial to skin metabolism, and has anti-wrinkle and anti-aging functions; the present invention reduces the influence of exogenous factors, inhibits the production of melanin, promptly removes free radicals in the body, and supplements peptides and NAD that have skin function improvement + Coenzyme, has a good anti-aging effect.

[0033] 3. The raw materials provided by the present invention are environmentally friendly, healthy, non-toxic, non-addictive, can be used for a long time, have good effects on inhibiting skin melanin and anti-aging, and can be used alone or in combination with other skin care products in the form of emulsions, solutions, pastes, gels or sprays. DETAILED DESCRIPTION

[0034] In order to more clearly illustrate the overall concept of the present invention, a detailed description is given below by way of examples.

[0035] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Therefore, the protection scope of the present invention is not limited to the specific embodiments disclosed below.

[0036] Unless otherwise specified, the raw materials, reagents or devices used in the following examples can be obtained from conventional commercial sources or can be obtained by existing known methods; unless otherwise specified, the methods used in the examples of the present invention are methods known to those skilled in the art.

[0037] Hereinafter, the composition with melanin inhibition and anti-aging effects and its application in the present invention will be described in detail in conjunction with exemplary embodiments.

[0038] In order to better reflect the efficacy of the composition, the specific implementation methods of the present application are to prepare the composition into an emulsion form for experimental testing. However, in specific applications, it is not limited to an emulsion product form. For example, the composition in the present application can also be prepared into a solution, paste, gel or spray product form.

[0039] Example 1 Preparation of product

[0040] The preparation method of product 1# comprises the following steps:

[0041] 1. Stir and disperse 20g of phenyl trimethylsiloxane, 35g of polydimethylsiloxane, 10g of acrylate cross-linked polymer, and 10g of hyaluronic acid to obtain phase A;

[0042] 2. Mix 1g nano zinc oxide, 30g calamine, 1g NAD + , 5g sodium ascorbyl phosphate, 2g carbomer, 2g triethanolamine, 700g water, stir and disperse evenly to obtain phase B;

[0043] 3. Stir and disperse 1g tocopherol acetate, 0.05g nonapeptide-1, 0.03g palmitoyl tripeptide-1, 0.02g palmitoyl tetrapeptide-7, 0.5g glutathione, 50g glycerin, 80g propylene glycol, and 10g phenoxyethanol / ethylhexylglycerin to obtain phase C;

[0044] 4. Mix phases A, B, and C, add sodium carbonate aqueous solution to adjust the pH value to 7.6, place in a water bath at 40°C for 30 minutes and stir to obtain an emulsion.

[0045] The emulsion prepared above with the effects of inhibiting melanin and anti-aging is recorded as product 1#.

[0046] According to the preparation method of product 1#, the dosage of components was adjusted to prepare products 1#-10# and products D1#-D4#. The specific formulas are shown in Table 1. Products 1#-10# are the experimental group, and products D1#-D4# are the control group.

[0047]

[0048]

[0049]

[0050] Example 2

[0051] The emulsion product prepared by the method of Reference Example 1 is different in that Example 2 is set according to the parameter conditions of Product 2# in Table 1, and other conditions are the same as Example 1, to prepare Product 2#.

[0052] Example 3

[0053] The emulsion product prepared by the method of Reference Example 1 is different in that Example 3 is set according to the parameter conditions of Product 3# in Table 1, and other conditions are the same as Example 1, to prepare Product 3#.

[0054] Example 4

[0055] The emulsion product prepared by the method of Reference Example 1 is different in that Example 4 is set according to the parameter conditions of Product 4# in Table 1, and other conditions are the same as Example 1, to prepare Product 4#.

[0056] Example 5

[0057] The emulsion product prepared by the method of Reference Example 1 is different in that Example 5 is set according to the parameter conditions of Product 5# in Table 1, and other conditions are the same as Example 1, to prepare Product 5#.

[0058] Example 6

[0059] The emulsion product was prepared by the method of Reference Example 1, except that Example 6 was set according to the parameter conditions of Product 6# in Table 1, and oligopeptide-1 was used instead of nonapeptide-1. The other conditions were the same as those of Example 1, and Product 6# was prepared.

[0060] Example 7

[0061] The emulsion product was prepared by the method of Reference Example 1, except that Example 7 was set according to the parameter conditions of Product 7# in Table 1, and palmitoyl tripeptide 5 was used instead of palmitoyl tripeptide-1. The other conditions were the same as those of Example 1, and Product 7# was prepared.

[0062] Example 8

[0063] The emulsion product was prepared by the method of Reference Example 1, except that Example 8 was set according to the parameter conditions of Product 8# in Table 1, and acetyl octapeptide-3 was used instead of palmitoyl tetrapeptide-7. The other conditions were the same as those of Example 1, and Product 8# was prepared.

[0064] Example 9

[0065] The emulsion product was prepared by the method of Reference Example 1, except that Example 9 was set according to the parameter conditions of Product 9# in Table 1, and glutathione was replaced by carnosine. Other conditions were the same as those of Example 1, and Product 9# was prepared.

[0066] Example 10

[0067] The emulsion product prepared by the method of Reference Example 1 is different in that Example 10 is set according to the parameter conditions of Product 10# in Table 1, and the products are directly physically mixed. Other conditions are the same as those of Example 1, to prepare Product 10#.

[0068] Comparative Example D1

[0069] The emulsion product prepared by the method of reference Example 1 is different in that the comparative example D1 is set according to the parameter conditions of product D1# in Table 1, and deoxynucleotides are used instead of NAD + Coenzyme and other conditions were the same as in Example 1 to prepare product D1#.

[0070] Comparative Example D2

[0071] The emulsion product prepared by the method of reference Example 1 is different in that comparative example D2 is set according to the parameter conditions of product D2# in Table 1, and nano-zinc oxide and calamine are replaced by nano-titanium dioxide and pearl powder. Other conditions are the same as those of Example 1, and product D2# is prepared.

[0072] Comparative Example D3

[0073] The emulsion product was prepared by the method of reference Example 1, except that the comparative example D3 was set according to the parameter conditions of product D3# in Table 1, and carnosine, oligopeptide-1, acetyl hexapeptide-3, and palmitoyl hexapeptide-1 were used to replace the polypeptide composition. The other conditions were the same as in Example 1 to prepare product D3#.

[0074] Comparative Example D4

[0075] The emulsion product was prepared by the method of Reference Example 1, except that the comparative example D4 was set according to the parameter conditions of the product D4# in Table 1, and ascorbyl tetraisopalmitate and tocopherol phosphate were used instead of sodium ascorbyl phosphate and tocopherol acetate. The other conditions were the same as those in Example 1, and product D4# was prepared.

[0076] Experimental example

[0077] The above groups of products were tested for melanin inhibition, melanin reduction, melanin blocking, and anti-aging performance. The test methods and results are as follows:

[0078] 1. Melanin inhibition performance test

[0079] Experimental conditions: A certain number of healthy volunteers, 60 in total, aged between 20 and 45 years old, half male and half female, were recruited and randomly divided into 15 groups, 4 people in each group; groups 1-10 used products 1-10#, groups 11-14 used products D1-D4#, and group 15 used ordinary skin care products available on the market.

[0080] Test method: The test site is the skin of the subject's left and right arms, 5 cm away from the base of the palm, with a test area of ​​3×3 cm. Before the test, each experimental group used the Mexameter MX 16 skin melanin and hemoglobin tester to measure the pigment content and skin color of the test site skin, and tested it three times in a row to take the average value. After the test started, groups 1-10 used 1-10# product samples for 4 consecutive weeks, groups 11-14 used D1-D4# product samples for 4 consecutive weeks, and group 15 used ordinary skin care products on the market, once in the morning and evening every day, and tested the melanin value of the test site of the subject every 7 days; before the test, the subject was required to sit quietly for 30 minutes in an environment with an indoor temperature of 21±1℃ and a relative humidity of 50±10%, and 3 parallel data were measured each time, and the average value was taken.

[0081]

[0082] The melanin inhibition rate results obtained from the test are shown in Table 2 below.

[0083] Table 2 Melanin inhibition rate

[0084] Group Inhibition rate / % Product 1# 83.5 Product 2# 73.6 Product 3# 73.2 Product 4# 71.2 Product 5# 71.7 Product 6# 66.5 Product 7# 67.2 Product 8# 66.9 Product 9# 67.3 Product 10# 68.2 Product D1# 55.8 Product D2# 57.6 Product D3# 43.2 Product D4# 65.4 Common skin care products on the market 13.8

[0085] Experimental conclusion: From the experimental results, it can be seen that products 1#-10# can inhibit melanin, and the inhibitory effect of products 1-5# is more obvious, especially product 1# has the best inhibitory effect, which shows that the nano zinc oxide, calamine, sodium ascorbyl phosphate, tocopherol acetate, NAD + When nonapeptide-1, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, and glutathione are mixed in a certain proportion, the inhibitory effect is more significant, indicating that there is a synergistic effect among the components, which can better inhibit the formation of melanin and prevent pigment deposition.

[0086] 2. Melanin reduction experiment

[0087] Experimental conditions: 60 female volunteers aged between 18 and 50 were recruited and randomly divided into 15 groups, with 4 people in each group. After being exposed to the sun for 3 hours, the human epidermal tissues were collected, and the color of the epidermal tissues was obviously deepened. The melanocytes were marked with fluorescent labeling. Then, the epidermal tissues taken from groups 1-10 were smeared with 1-10# products, the epidermal tissues taken from groups 11-14 were smeared with D1-D4# products, and the epidermal tissues taken from group 15 were smeared with commercially available ordinary skin care products. Under the conditions of ambient temperature of 25±1℃ and humidity of 50±5%, the MEXAMETER MX 16 skin pigmentation analyzer was used to observe the reduction of melanin.

[0088]

[0089] The melanin reduction rate results obtained from the test are shown in Table 3 below:

[0090] Table 3 Melanin reduction rate

[0091] Group Reduction rate / % Product 1# 84.7 Product 2# 73.5 Product 3# 72.8 Product 4# 70.6 Product 5# 71.4 Product 6# 67.5 Product 7# 66.2 Product 8# 67.1 Product 9# 67.3 Product 10# 66.4 Product D1# 53.9 Product D2# 51.7 Product D3# 40.6 Product D4# 62.5 Common skin care products on the market 10.6

[0092] Experimental conclusion: From the experimental results, it can be seen that products 1#-10# can improve skin whiteness and skin color uniformity, skin spots and dullness, and the improvement effect of products 1-5# is more obvious, especially product 1# has the best improvement effect. This shows that the nano zinc oxide, calamine, sodium ascorbyl phosphate, tocopherol acetate, NAD +Coenzyme, nonapeptide-1, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7 and glutathione can work synergistically with each other to achieve better whitening effects.

[0093] 3. Melanin blocking experiment

[0094] Experimental conditions: 60 female volunteers aged between 18 and 50 were recruited and randomly divided into 15 groups, with 4 people in each group. Groups 1-10 were applied with products 1-10# on their back skin, groups 11-14 were applied with products D1-D4# on their back skin, and group 15 was applied with ordinary commercially available skin care products on their back skin. After the back skin was exposed to the sun for 3 hours, the increase of melanin was observed using MEXAMETER MX 16 skin pigmentation analyzer at an ambient temperature of 25±1℃ and a humidity of 50±5%.

[0095]

[0096] The melanin blocking rate results obtained from the test are shown in Table 4 below:

[0097] Table 4 Melanin blocking rate

[0098]

[0099]

[0100] Experimental conclusion: From the experimental results, it can be seen that products 1-10# can promote the blocking of melanin, and the promotion effect of products 1-5# is more obvious, especially product 1# has the best promotion effect. This is because the products used in this application can reduce the melanin on the skin surface to colorless melanin precursors, while removing free radicals, thereby reducing the damage of free radicals to skin cells, maintaining the skin's own metabolic capacity, and reducing the deposition of pigments, thereby achieving the effect of whitening, brightening and lightening spots. + Coenzyme, nonapeptide-1, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7 and glutathione can work synergistically with each other to achieve better whitening effects.

[0101] 4. Anti-aging performance test

[0102] 80 healthy female testers aged 25 to 35 with similar indicators were selected. The above melanin-inhibiting and anti-aging products and ordinary commercial skin care products were applied to the back skin, and applied to the face after washing with water every morning and evening for 30 consecutive days. The wrinkles at the corners of the eyes and skin elasticity were observed every day. At the end, the testers scored the wrinkles and skin elasticity weighted averagely, and the scoring results are recorded in Table 5.

[0103] Wrinkle scoring standard: 1 to 9 rating standard (7-9 points indicate no wrinkles or slight wrinkles, 4-6 points indicate superficial wrinkles or moderate wrinkles, 1-3 indicates severe wrinkles);

[0104] Skin elasticity scoring standard: 1 to 9 rating standard (7-9 points indicate that the skin is smooth, firm, delicate and elastic, 4-6 points indicate that the skin has a certain elasticity and is relatively stable, 1-3 points indicate that the skin is dry, loose and lacks elasticity).

[0105] Table 5 Product anti-aging test results

[0106]

[0107]

[0108] Experimental conclusion: The larger the value, the greater the degree of wrinkle reduction and the better the skin elasticity. From the above results, it can be seen that products 1-10# can help reduce wrinkles and improve skin elasticity, and the improvement effect of products 1-5# is more obvious, especially product 1# has the best anti-aging effect in reducing wrinkles and improving skin elasticity. This shows that the nano zinc oxide, calamine, sodium ascorbyl phosphate, tocopherol acetate, NAD + Coenzyme, nonapeptide-1, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7 and glutathione can work synergistically with each other to achieve better anti-aging effects.

[0109] The above is only the embodiment of the present application, and the protection scope of the present application is not limited by these specific embodiments, but is determined by the claims of the present application. For those skilled in the art, the present application can have various changes and variations. Any modification, equivalent replacement, improvement, etc. made within the technical ideas and principles of the present application should be included in the protection scope of the present application.

Claims

1. A composition having melanin inhibition and anti-aging effects, characterized in that: The components of the composition include: nano zinc oxide, calamine, sodium ascorbyl phosphate, tocopherol acetate, polypeptide complex and coenzyme.

2. The composition according to claim 1, characterized in that Calculated by weight, the composition comprises 0.05-2 parts of nano zinc oxide, 1-10 parts of calamine, 0.1-2 parts of sodium ascorbyl phosphate, 0.05-2 parts of tocopherol acetate, 0.013-0.89 parts of polypeptide complex and 0.05-2 parts of coenzyme.

3. The composition according to claim 1, characterized in that The composition comprises, by weight, 0.1-1 parts of nano zinc oxide, 3-8 parts of calamine, 0.5-1.5 parts of sodium ascorbyl phosphate, 0.1-1 parts of tocopherol acetate, 0.06-0.64 parts of polypeptide complex, and 0.1-1 parts of coenzyme; Preferably, the composition comprises, by weight, 0.4 parts of nano zinc oxide, 5 parts of calamine, 1 part of sodium ascorbyl phosphate, 0.5 parts of tocopherol acetate, 0.5175 parts of polypeptide complex, and 0.5 parts of coenzyme.

4. The composition according to claim 1, characterized in that By weight, the polypeptide complex comprises 0.001-0.05 parts of nonapeptide-1, 0.001-0.02 parts of palmitoyl tripeptide-1, 0.001-0.02 parts of palmitoyl tetrapeptide-7 and 0.01-0.8 parts of glutathione.

5. The composition according to claim 1, characterized in that By weight, the polypeptide complex comprises 0.005-0.02 parts of nonapeptide-1, 0.003-0.01 parts of palmitoyl tripeptide-1, 0.002-0.01 parts of palmitoyl tetrapeptide-7 and 0.05-0.6 parts of glutathione. Preferably, the polypeptide complex comprises, by mass, 0.01 parts of nonapeptide-1, 0.005 parts of palmitoyl tripeptide-1, 0.0025 parts of palmitoyl tetrapeptide-7 and 0.5 parts of glutathione.

6. The composition according to claim 1, characterized in that The coenzyme is any one of nicotinamide adenine dinucleotide and nicotinamide mononucleotide; Preferably, the coenzyme is nicotinamide adenine dinucleotide.

7. A method for preparing an emulsion having melanin inhibition and anti-aging effects, characterized in that: The following steps are involved: S1. Stirring the oil-soluble silicone oil, the humectant and the thickener to obtain phase A; S2. Stir nano zinc oxide, calamine, coenzyme, sodium ascorbyl phosphate, carbomer, triethanolamine and water to obtain phase B; S3. stirring the tocopherol acetate, the polypeptide complex, and the emulsifier to obtain phase C; S4. Mix phases A, B and C to obtain a composite.

8. The method for preparing the emulsion according to claim 7, characterized in that: In step S1, the oil-soluble silicone oil is composed of at least one of phenyl trimethylsiloxane and polydimethylsiloxane; the moisturizer is composed of at least one of hyaluronic acid and sodium hyaluronate; and the thickener is acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer.

9. The method for preparing the emulsion according to claim 7, characterized in that: In the step S4, the pH value of the composition is adjusted to 7.6 by using a pH adjuster, and the mixture is mixed in a water bath at 40° C. for 30 minutes to obtain the mixture.

10. Use of the composition according to any one of claims 1 to 6 in cosmetics, health products, and medicines, wherein the composition can be made into an emulsion, solution, paste, gel, or spray form.

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