Portable automatic blood purification system

Abstract

The invention relates to a portable automatic blood purification system, and belongs to the technical field of blood purification medical equipment. The system comprises an artificial kidney unit, an artificial liver unit, a flushing unit, a weighing unit, a blood inlet tube and a blood outlet tube. The artificial kidney unit comprises a first peristaltic pump, a second peristaltic pump, a first dialyzer, a fourth peristaltic pump, an anticoagulant container and an injection pump; the artificial liver unit comprises a second dialyzer, a hemoperfusion device, an albumin storage container and a third peristaltic pump; the device is characterized by further comprising an artificial lung unit composed of an oxygen container, and the oxygen container is connected between the second outlet of the second compartment of the first dialyzer and the inlet of the second peristaltic pump in parallel through two switches. The device is provided with an emergency life maintenance function device combining the artificial kidney, the artificial liver and the artificial lung, the artificial lung unit is additionally arranged, and when a patient is in a coma condition, timely treatment is achieved by conveying oxygen. The invention is suitable for war, serious injury, burn, poisonous snake and insect bites, pesticide poisoning and other occasions.

Description

Technical Field

[0001] The invention belongs to the technical field of blood purification medical equipment, and in particular relates to blood purification equipment for artificial kidneys and artificial livers. Background Art

[0002] In some serious and critical situations, such as snake and insect bites and pesticide poisoning, artificial liver technology is urgently needed to remove water-insoluble toxins from the body; war, serious injuries, large-area burns, etc. can also lead to kidney failure and artificial kidneys are urgently needed to maintain life. However, these situations are often accompanied by coma of the patient, and oxygen needs to be delivered at the same time.

[0003] In addition, the existing blood purification system needs to manually fill the pipeline with dialysate and remove bubbles before use. This process requires extremely high operator experience. At the same time, after use, the pipeline still filled with dialysate or even patient blood is often directly discarded, which easily causes medical waste pollution. Therefore, there is an urgent need for a blood purification system that can automatically pre-fill the system pipeline before use and automatically clean the pipeline after use.

[0004] In summary, there is an urgent need for a blood purification system that has both artificial kidney and artificial liver functions as well as artificial lung functions. Such a device can achieve emergency rescue. Summary of the invention

[0005] In order to realize emergency rescue, the blood purification medical equipment has both artificial kidney and artificial liver functions and artificial lung functions. The present invention provides a portable automatic blood purification system.

[0006] The portable automated blood purification system comprises an artificial kidney unit, an artificial liver unit, a flushing unit, a weighing unit, a blood inlet tube 101 and a blood outlet tube 102; The artificial kidney unit includes a first peristaltic pump 128, a second peristaltic pump 142, a first dialyzer 104, a fourth peristaltic pump 108, an anticoagulant container 123 and a syringe pump 122; The artificial liver unit includes a second dialyzer 802, and also includes a blood perfusion device 808, an albumin storage container 812 and a third peristaltic pump 810 connected in series with the second dialyzer 802 to form a loop; The flushing unit includes a third weighing sensor 114, a first perfusion backwashing tube 107, and a second perfusion backwashing tube 105; The weighing unit includes a first weighing sensor 118 and a second weighing sensor 116; It also includes an artificial lung unit; the artificial lung unit includes an oxygen container 902, the inlet and outlet of the oxygen container 902 are connected in parallel to the second outlet of the second compartment 150 of the first dialyzer 104 and the inlet of the second peristaltic pump 142 through a switch.

[0007] The further technical solution is as follows: The inlet of the first peristaltic pump 128 of the artificial kidney unit is connected in series with the blood inlet tube 101; The inlet of the second peristaltic pump 142 is connected to the replacement supplement tank 125 through the first weighing sensor 118, and the first weighing sensor 118 is also connected to one end of the first perfusion backwash tube 107 and one end of the second perfusion backwash tube 105 respectively; the other end of the first perfusion backwash tube 107 is connected to the blood outlet tube 102 through the fourth optional switch 1212 and the three-way tube connected in series; the other end of the second perfusion backwash tube 105 is connected to the blood inlet tube 103 through the third optional switch 1208 and the three-way tube connected in series; The inlet of the injection pump 122 is connected in series with the anticoagulant container 123; The outlet of the first peristaltic pump 128, the outlet of the second peristaltic pump 142 and the outlet of the syringe pump 122 are connected to the inlet of the first compartment 148 of the first dialyzer 104 through a four-way pipe; the outlet of the first compartment 148 of the first dialyzer 104 is connected to the blood outlet tube 102 through the first optional switch 820, the second optional switch 821 and the bubble eliminator 134 connected in series; The inlet of the fourth peristaltic pump 108 is connected to the first outlet of the second compartment 150 of the first dialyzer 104 , and the outlet of the fourth peristaltic pump 108 is connected to the first load cell 118 or the second load cell 116 via the fifth optional switch 1204 .

[0008] The artificial lung unit also includes a first switch 911 and a second switch 910; the first switch 911 is connected in series between the second outlet of the second compartment 150 of the first dialyzer 104 and the outlet of the oxygen container 902, and the second switch 910 is connected in series between the inlet of the second peristaltic pump 142 and the inlet of the oxygen container 902.

[0009] The first switch 911 and the second switch 910 are both two-input and one-output switching valves.

[0010] The oxygen container 902 is a bubbling oxygenator.

[0011] The beneficial technical effects of the present invention are embodied in the following aspects: 1. The present invention provides an artificial lung structure to deliver oxygen to patients in a coma. The present invention has an emergency life-sustaining function that combines artificial kidneys, artificial livers and artificial lungs. When used for emergency rescue, it is portable, efficient and flexible, and has great practical significance for rescuing the wounded in wars, serious injuries, burns, snake and insect bites, pesticide poisoning and other situations. 2. The portable automated blood purification system of the present invention has a high degree of automation, and has the function of automatically pre-filling the pipeline and removing bubbles before use, and can automatically clean the pipeline after use. All operation processes have a high degree of automation. The system is also small and portable. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 It is a schematic diagram of the overall functions of the portable automated blood purification system.

[0013] Figure 2 This is a schematic diagram of the workflow of an artificial kidney unit that removes water-soluble toxins from the blood.

[0014] Figure 3 This is a schematic diagram of the workflow of the artificial liver unit.

[0015] Figure 4 is a schematic diagram of the workflow with an artificial liver unit and an artificial lung unit.

[0016] Figure 5 It is a schematic diagram of the workflow of automatic perfusion.

[0017] Figure 6 This is a schematic diagram of the workflow of automatic recoil.

[0018] Figure 1-6Sequence number: blood outlet tube 102, blood inlet tube 103, first dialyzer 104, second perfusion backwash tube 105, first perfusion backwash tube 107, dialysis membrane 106, fourth peristaltic pump 108, pipeline 110, third weighing sensor 114, second weighing sensor 116, first weighing sensor 118, medical fluid warmer 120, injection pump 122, anticoagulant container 123, fourth temperature and pressure sensor 124, replacement replenishment tank 125, second bubble detection sensor 126, first peristaltic pump 128, clamping tube solenoid valve 130, first bubble detection sensor 132, bubble eliminator 134, second temperature and pressure sensor 136, blood leakage detection sensor Sensor 138, third temperature and pressure sensor 140, second peristaltic pump 142, first temperature and pressure sensor 144, second dialyzer 802, blood perfusion device 808, third peristaltic pump 810, albumin storage container 812, first optional switch 820, second optional switch 821, fifth optional switch 1204, third optional switch 1208, fourth optional switch 1212, oxygen container 902, second switch 910, first switch 911; the first dialyzer 104 includes: dialysis membrane 106, first compartment 148, second compartment 150; the second dialyzer 802 includes: first compartment 804, second compartment 806, second dialysis membrane 818. DETAILED DESCRIPTION

[0019] The present invention will be further described in detail below through embodiments in conjunction with the accompanying drawings. Example

[0020] See also Figure 1 The portable automated blood purification system includes an artificial kidney unit, an artificial liver unit, a flushing unit, a weighing unit, a blood inlet tube 101, a blood outlet tube 102 and an artificial lung unit.

[0021] The artificial kidney unit includes a first peristaltic pump 128 , a second peristaltic pump 142 , a first dialyzer 104 , a fourth peristaltic pump 108 , an anticoagulant container 123 , and a syringe pump 122 .

[0022] The inlet of the first peristaltic pump 128 of the artificial kidney unit is connected in series with the blood inlet tube 101; the inlet of the second peristaltic pump 142 is connected to the replacement supplement tank 125 through the first weighing sensor 118, and the first weighing sensor 118 is also connected to one end of the first perfusion backwash tube 107 and one end of the second perfusion backwash tube 105 respectively; the other end of the first perfusion backwash tube 107 is connected to the blood outlet tube 102 through the fourth optional switch 1212 and the three-way tube connected in series; the other end of the second perfusion backwash tube 105 is connected to the blood inlet tube 103 through the third optional switch 1208 and the three-way tube connected in series.

[0023] The inlet of the syringe pump 122 is connected in series with the anticoagulant container 123 .

[0024] The outlet of the first peristaltic pump 128, the outlet of the second peristaltic pump 142 and the outlet of the injection pump 122 are connected to the inlet of the first compartment 148 of the first dialyzer 104 through a four-way tube; the outlet of the first compartment 148 of the first dialyzer 104 is connected to the blood outlet tube 102 through the first optional switch 820, the second optional switch 821 and the bubble eliminator 134 connected in series.

[0025] The inlet of the fourth peristaltic pump 108 is connected to the first outlet of the second compartment 150 of the first dialyzer 104 , and the outlet of the fourth peristaltic pump 108 is connected to the first load cell 118 or the second load cell 116 via the fifth selectable switch 1204 .

[0026] The artificial liver unit includes a second dialyzer 802 , and also includes a blood perfusion device 808 , an albumin storage container 812 , and a third peristaltic pump 810 connected in series with the second dialyzer 802 to form a loop.

[0027] The flushing unit includes a third weighing sensor 114 , a first irrigation backwashing tube 107 , and a second irrigation backwashing tube 105 .

[0028] The weighing unit includes a first load cell 118 and a second load cell 120 .

[0029] The artificial lung unit includes an oxygen container 902, which is a bubbling oxygenator. The inlet and outlet of the oxygen container 902 are connected in parallel to the second outlet of the second compartment 150 of the first dialyzer 104 and the inlet of the second peristaltic pump 142 through switches, respectively. The specific structure is as follows: the first switch 911 is connected in series between the second outlet of the second compartment 150 of the first dialyzer 104 and the outlet of the oxygen container 902, and the second switch 910 is connected in series between the inlet of the second peristaltic pump 142 and the inlet of the oxygen container 902.

[0030] The first switch 911 and the second switch 910 are both two-input and one-output switching valves.

[0031] The detailed description of each workflow of the present invention is as follows: 1. Artificial kidney unit workflow (main function) See also Figure 2 , place the first optional switch 820 in position "A", the second optional switch 821 in position "A", the third optional switch 1208 in position "B", the fourth optional switch 1212 in position "A", and the fifth optional switch 1204 in position "B", and disconnect the first switch 911 and the second switch 910.

[0032] At this time, the system is driven by the first peristaltic pump 128, and the blood drawn from the patient's vein enters through the blood inlet tube 103 in sequence through the fourth temperature and pressure sensor 124 (and the weight of the blood is weighed by the third weighing sensor 114 at the same time), the second bubble detection sensor 126, and the first peristaltic pump 128, and enters the first dialyzer 104 through the first temperature and pressure sensor 144, flows out after passing through the first compartment 148 divided by the dialysis membrane 106 of the first dialyzer 104, passes through the second temperature and pressure sensor 136, and then passes through the first optional switch 820, the second optional switch 821, the bubble eliminator 134, the first bubble detection sensor 132, and the tube clamping solenoid valve 130 (which is in the on state at this time), so that the blood returns to the patient's artery through the blood outlet tube 102.

[0033] When the blood enters the first dialyzer 104, the dialysis membrane 106 will filter out part of the blood, which is driven by the fourth peristaltic pump 108, passes through the third temperature and pressure sensor 140, the blood leakage detection sensor 138, and the fourth peristaltic pump 108, and is weighed by the second weighing sensor 116 before being discarded.

[0034] When the blood enters the first temperature and pressure sensor 144 through the first peristaltic pump 128, the syringe pump 122 can add the anticoagulant in the anticoagulation container 123 to the blood. At the same time, driven by the second peristaltic pump 142, the dialysate in the replacement supplement tank 125 is heated by the medical fluid heater 120, weighed by the first weighing sensor 118, and then injected into the blood of the first dialyzer 104 through the pipeline 110 by the second peristaltic pump 142.

[0035] 2. Artificial liver unit workflow (optional function) See also Figure 3 The artificial liver unit is based on the artificial kidney unit, with the first optional switch 820 placed in position "B" and the second optional switch 821 placed in position "B". The blood flowing out of the first dialyzer 104 flows into the second dialyzer 802 through the second temperature and pressure sensor 136, flows out through the first compartment 804 separated by the second dialyzer membrane 818 of the second dialyzer 802, and enters the bubble eliminator 134 through the second optional switch 821; then passes through the first bubble detection sensor 132 and the clamping solenoid valve 130 (which is in the on state at this time), and then returns to the patient's artery through the blood outlet tube 102.

[0036] When the blood enters the second dialyzer 802, the second dialysis membrane 818 will filter out part of the blood, which is driven by the third peristaltic pump 810 and flows through the blood perfusion device 808 to remove non-water-soluble toxins such as bilirubin in the blood, and replenishes the albumin in the blood when flowing through the albumin storage container 812.

[0037] 3. Artificial Lung Unit Workflow (Optional Function) See also Figure 4 The artificial lung unit is based on the artificial kidney unit or the artificial liver unit, and the first switch 911 is closed and the second switch 910 is closed. When the blood enters the first dialyzer 104, the dialysis membrane 106 filters out part of the blood, passes through the oxygen container 902, and then flows back to the pipeline 110 through the second switch 910, and then the second peristaltic pump 142 drives the first temperature and pressure sensor 144 to re-inject the blood with increased oxygen content into the first dialyzer 104.

[0038] 4. Automated infusion workflow See also Figure 5 , the first optional switch 820 is placed in position "A", the second optional switch 821 is placed in position "A", the third optional switch 1208 is placed in position "B", the fourth optional switch 1212 is placed in position "A", and the fifth optional switch 1204 is placed in position "B", and the first switch 911 and the second switch 910 are disconnected. At the same time, the first peristaltic pump 128 and the second peristaltic pump 142 rotate in the opposite direction and output in the opposite direction.

[0039] The dialysate in the replacement supplement tank 125 passes through the medical fluid heater 120 (the heating function is not turned on at this time) and the first weighing sensor 118 and is divided into two paths: One of the paths passes through the first perfusion backflush tube 107, the fourth optional switch 1212, the tube clamping solenoid valve 130, the first bubble detection sensor 132, the bubble eliminator 134, and then passes through the second optional switch 821 and the first optional switch 820, the second temperature and pressure sensor 136 to enter the first dialyzer 104, and perfuse and fill the first compartment 148 and the second compartment 150 on both sides of the dialysis membrane 106 of the first dialyzer 104.

[0040] After filling the first compartment 148, the dialysate flows through the first temperature and pressure sensor 144, and then is driven by the first peristaltic pump 128, flows through the second bubble detection sensor 126, the fourth temperature and pressure sensor 124, the third optional switch 1208, the second perfusion backwash tube 105, the first weighing sensor 118, and the medical fluid heater 120, and then flows back to the replacement replenishment tank 125. After filling the first compartment 150, the dialysate is driven by the fourth peristaltic pump 108 to flow through the third temperature and pressure sensor 140, the blood leakage detector 138, and then flows back to the replacement replenishment tank 125 through the fifth optional switch 1204, the first weighing sensor 118, and the medical fluid heater 120.

[0041] The other route is driven by the second peristaltic pump 142 and directly enters the first temperature and pressure sensor 144 through the pipeline 110 .

[0042] 5. Automatic backflush workflow See also Figure 6, adjust the first peristaltic pump 128 and the second peristaltic pump 142 to rotate in opposite directions, so as to realize the main circuit and Figure 5 Cleaning pipeline process in the opposite direction.

[0043] The portable automated blood purification system of the present invention is a portable box-shaped complete machine, the dimensions of which are less than 55 cm×40 cm×20 cm, and the weight of which is less than 12 kg.

Claims

1. A portable automated blood purification system, comprising an artificial kidney unit, an artificial liver unit, a flushing unit, a weighing unit, a blood inlet tube (101) and a blood outlet tube (102); The artificial kidney unit comprises a first peristaltic pump (128), a second peristaltic pump (142), a first dialyzer (104), a fourth peristaltic pump (108), an anticoagulant container (123) and a syringe pump (122); The artificial liver unit comprises a second dialyzer (802), and also comprises a blood perfusion device (808) connected in series with the second dialyzer (802) to form a loop, an albumin storage container (812) and a third peristaltic pump (810); The flushing unit comprises a third weighing sensor (114), a first perfusion backwashing tube (107), and a second perfusion backwashing tube (105); The weighing unit comprises a first weighing sensor (118) and a second weighing sensor (116); Features: It also includes an artificial lung unit; the artificial lung unit includes an oxygen container (902), the inlet and outlet of the oxygen container (902) are respectively connected in parallel through a switch to the second outlet of the second compartment (150) of the first dialyzer (104) and the inlet of the second peristaltic pump (142).

2. The portable automated blood purification system according to claim 1, characterized in that: The inlet of the first peristaltic pump (128) of the artificial kidney unit is connected in series with the blood inlet tube (101); The inlet of the second peristaltic pump (142) is connected to the replacement supplement tank (125) via the first weighing sensor (118), and the first weighing sensor (118) is also connected to one end of the first perfusion backwash tube (107) and one end of the second perfusion backwash tube (105) respectively; the other end of the first perfusion backwash tube (107) is connected to the blood outlet tube (102) via the fourth optional switch (1212) and the three-way tube connected in series; the other end of the second perfusion backwash tube (105) is connected to the blood inlet tube (103) via the third optional switch (1208) and the three-way tube connected in series; The inlet of the injection pump (122) is connected in series with the anticoagulant container (123); The outlet of the first peristaltic pump (128), the outlet of the second peristaltic pump (142) and the outlet of the injection pump (122) are connected to the inlet of the first compartment (148) of the first dialyzer (104) via a four-way tube; the outlet of the first compartment (148) of the first dialyzer (104) is connected to the blood outlet tube (102) via a first optional switch (820), a second optional switch (821) and a bubble eliminator (134) connected in series; The inlet of the fourth peristaltic pump (108) is connected to the first outlet of the second compartment (150) of the first dialyzer (104), and the outlet of the fourth peristaltic pump (108) is connected to the first weighing sensor (118) or the second weighing sensor (116) through the fifth optional switch (1204).

3. The portable automated blood purification system according to claim 1, characterized in that: The artificial lung unit further comprises a first switch (911) and a second switch (910); the first switch (911) is connected in series between the second outlet of the second compartment (150) of the first dialyzer (104) and the outlet of the oxygen container (902); the second switch (910) is connected in series between the inlet of the second peristaltic pump (142) and the inlet of the oxygen container (902).

4. The portable automated blood purification system according to claim 1, characterized in that: The first switch (911) and the second switch (910) are both two-input and one-output switching valves.

5. The portable automated blood purification system according to claim 1, characterized in that: The oxygen container (902) is a bubbling oxygenator.

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