Ingredient adding equipment and ingredient adding method for valsartan production

Abstract

The invention discloses valsartan production ingredient adding equipment and an ingredient adding method.The valsartan production ingredient adding equipment comprises an infiltration mechanism, an auxiliary mechanism, a cover plate and a feeding pipe, atomization nozzles are annularly and evenly distributed in an infiltration ring, and therefore water mist in an infiltration tank body and a mechanism tank body is distributed more evenly; the material distributing baffle can scatter powder entering the infiltrating tank body and the mechanism tank body, meanwhile, the material distributing baffle is matched with the powder raising fan to raise the distributed materials in the mechanism tank body and the infiltrating tank body, and the powder flying in the infiltrating tank body is combined with water mist in the infiltrating tank body, so that the infiltrating effect on the powder is improved; the infiltrating rings and the inner walls of the infiltrating tanks on the two sides are in smooth transition to form inclined planes, and water mist can smoothly flow along with the surfaces of the infiltrating rings, the surfaces of the inner walls of the infiltrating tanks and the inclined planes between the infiltrating rings and the infiltrating tanks after being condensed on the surfaces of the infiltrating rings and the surfaces of the infiltrating tanks. Flying dust and water mist in the infiltrating tank body can be effectively prevented from caking on the surface of the infiltrating tank body.

Description

Technical Field

[0001] The invention relates to the technical field of pharmaceutical production equipment, and in particular to a valsartan production ingredient adding device and an ingredient adding method. Background Art

[0002] Valsartan levamlodipine is used to treat essential hypertension and is used for patients whose blood pressure cannot be adequately controlled by monotherapy. Valsartan levamlodipine is made of valsartan and levamlodipine besylate as raw materials and auxiliary materials, and then sprayed with liquid for wet granulation.

[0003] The existing device usually includes a tank body, in which an atomizing nozzle and a spiral tube are arranged. Liquid is sprayed into the tank body through the atomizing nozzle to form water mist, and an induced draft fan is connected to the spiral tube. The airflow of the induced draft fan guides the powdered material through the spiral tube and sprays it out through the nozzle on the side wall of the spiral tube. At the same time, it combines with the water mist sprayed by the atomizing nozzle in a suspended state to form a wet material. However, due to the design of the spiral tube, the wet material is easy to agglomerate on the spiral tube, which makes it difficult to maintain the device. Summary of the invention

[0004] The object of the present invention is to provide a valsartan production ingredient adding device and ingredient adding method, so as to solve the technical problem in the prior art that due to the design of the spiral tube, the wet material is easy to agglomerate on the spiral tube, causing difficulty in device maintenance work.

[0005] The technical problem to be solved by the present invention can be achieved by the following technical solutions:

[0006] A valsartan production ingredient adding device and ingredient adding method, comprising:

[0007] The infiltration mechanism comprises an infiltration tank body arranged horizontally, a plurality of infiltration rings are evenly distributed from bottom to top along the length direction of the infiltration tank body, the plurality of infiltration rings are fixedly connected to the inner wall of the infiltration tank body, atomizing nozzles are evenly distributed in annular shapes on the infiltration rings and are provided, a feeding tank body is arranged above the infiltration tank body, a guide tank body is arranged between the infiltration tank body and the feeding tank body, a material distribution baffle plate for breaking up the material powder and a material distribution motor for driving the material distribution baffle plate to rotate are arranged in the feeding tank body;

[0008] The auxiliary mechanism comprises a mechanism tank body, an opening is provided at the upper end of the mechanism tank body, a docking ring is fixedly connected to the edge of the opening of the mechanism tank body, a docking groove is provided on the docking ring, a powder raising fan is provided in the mechanism tank body, a powder raising motor for driving the powder raising fan to rotate is provided on the bottom surface of the mechanism tank body, and the infiltration tank body is sleeved on the docking groove on the docking ring;

[0009] The cover plate is arranged at the feeding place of the feeding tank body, and a feeding pipe is embedded through the end surface of the cover plate.

[0010] As a further solution of the present invention: an on-off valve 1 for controlling the on-off of the feed pipe is fixedly installed on the feed pipe, and an on-off valve 2 for controlling the on-off of the drain pipe is fixedly installed on the drain pipe.

[0011] As a further solution of the present invention: the infiltration tank body is cylindrical as a whole, the infiltration ring is protruded on the inner wall surface of the infiltration tank body, the cross-section of the infiltration ring is trapezoidal, the two ends of the protrusion of the infiltration ring and the inner wall surface of the infiltration tank body smoothly transition to form a slope, the pipe diameter of the feeding tank body is smaller than the pipe diameter of the infiltration tank body, and the guide tank body is an inclined truncated cone tubular tank body arranged between the infiltration tank body and the feeding tank body.

[0012] As a further solution of the present invention: water inlet pipes are evenly distributed in a ring on the outer end surface of the infiltration tank body, and water distribution pipes are embedded on the inner wall of the infiltration tank body. The water distribution pipes are connected to the atomizing nozzles on the infiltration ring, and the water inlet pipes are connected to the water distribution pipes.

[0013] As a further solution of the present invention: a fixed bracket is fixedly connected to the inner wall of the water inlet pipe, a material distribution motor is fixedly connected to the fixed bracket, an adapter is fixedly connected to the driving end of the material distribution motor, a material distribution baffle is evenly distributed in an annular shape and fixedly connected to the side end face of the adapter, and a connecting plate 1 is fixedly connected to the outer end face of the infiltration tank body.

[0014] As a further solution of the present invention: a connecting plate 2 corresponding to the connecting plate 1 is fixedly connected to the mechanism tank body, a connecting through hole is opened on the connecting plate 1, a threaded through hole is opened through the connecting plate 2, a bolt is threadedly connected between the connecting plate 1 and the connecting plate 2, and the bolt passes through the connecting through hole on the connecting plate 1 and is threadedly connected with the threaded through hole on the connecting plate 2.

[0015] As a further solution of the present invention: the powder raising motor is embedded through and fixedly connected to the bottom surface of the mechanism tank body, the driving end of the powder raising motor is coaxially fixedly connected with a driving shaft, and the powder raising fan is coaxially fixedly connected with the driving shaft.

[0016] A method for adding ingredients to valsartan production comprises the following steps

[0017] Step 1: Open the on-off valve 1 on the feed pipe, add various raw material powders into the infiltration tank through the feed pipe, and start the material distribution motor to drive the distribution baffle to rotate. The distribution baffle rotates to break up the raw material powder entering from the feed pipe. After the powder adding work is completed, close the on-off valve 1 on the feed pipe to make the mechanism tank and the infiltration tank airtight.

[0018] Step 2: Start the powder raising motor to drive the powder raising fan to rotate. The powder raising fan rotates to raise all the raw material powder in the infiltration tank and the mechanism tank, so that the raw material powder in the infiltration tank and the mechanism tank floats.

[0019] Step 3: Connect the water source to the water inlet pipe evenly distributed on the outside of the infiltration tank. The water flows through the water inlet pipe and then through the water distribution pipe to the atomizing nozzles evenly distributed in an annular shape on the infiltration ring, and then is atomized and sprayed out, so that the atomized water mist is evenly combined with the floating powder in the infiltration tank and the mechanism tank.

[0020] Step 4: The infiltration ring and the inner wall surface of the infiltration tank are smoothly transitioned and provided with an inclined surface, so that the water flow can flow smoothly between the infiltration ring and the surface of the infiltration tank to prevent the powder and water mist from agglomerating on the surface of the infiltration tank.

[0021] Beneficial effects of the present invention:

[0022] 1. When the present invention is in use, the water inlet pipe on the surface of the infiltration tank is connected to the water source, and the water flows through the water inlet pipe and reaches the atomizing nozzle on the infiltration ring after passing through the water distribution pipe. The infiltration ring is evenly distributed on the inner wall of the infiltration tank from bottom to top. At the same time, the atomizing nozzle is evenly distributed in an annular shape on the infiltration ring, so that the water mist distribution in the infiltration tank and the mechanism tank is more even. At the same time, the material distribution baffle is driven to rotate by the material distribution motor, and the material distribution baffle can break up the powder sent into the infiltration tank and the mechanism tank, and at the same time, the powder raising fan is used to raise the material in the mechanism tank and the infiltration tank, and the powder flying in the infiltration tank is combined with the water mist in the infiltration tank, thereby improving the infiltration effect of the powder;

[0023] 2. The infiltration ring of the present invention and the inner wall of the infiltration tank on both sides form an inclined surface in a smooth transition. After the water mist condenses on the surface of the infiltration ring and the surface of the infiltration tank, it will flow smoothly along the surface of the infiltration ring, the inner wall surface of the infiltration tank and the inclined surface between the infiltration ring and the infiltration tank, which can effectively prevent the flying dust in the infiltration tank and the agglomeration of water mist on the surface of the infiltration tank. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] The present invention will be further described below in conjunction with the accompanying drawings.

[0025] Figure 1 It is a schematic diagram of the three-dimensional structure of the present invention;

[0026] Figure 2 It is a schematic diagram of the cross-sectional structure of the infiltration mechanism of the present invention;

[0027] Figure 3 The present invention Figure 2 The enlarged structural diagram at A in the middle;

[0028] Figure 4 It is a schematic diagram of the three-dimensional structure of the auxiliary mechanism of the present invention;

[0029] Figure 5 It is a schematic cross-sectional structural diagram of the auxiliary mechanism of the present invention.

[0030] In the figure: 1. Wetting mechanism; 11. Wetting tank body; 12. Wetting ring; 13. Atomizing nozzle; 14. Water inlet pipe; 15. Water distribution pipe; 16. Diversion tank body; 17. Feed tank body; 18. Fixed bracket; 19. Distributing motor; 110. Adapter; 111. Distributing baffle; 112. Connecting plate 1; 2. Auxiliary mechanism; 21. Mechanism tank body; 22. Docking ring; 23. Docking groove; 24. Connecting plate 2; 25. Powder raising motor; 26. Powder raising fan; 27. Drain pipe; 3. Cover plate; 4. Feed pipe. DETAILED DESCRIPTION

[0031] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0032] like Figure 1-Figure 5 As shown, a valsartan production ingredient adding device and ingredient adding method include: an infiltration mechanism 1, an auxiliary mechanism 2 and a cover plate 3, the infiltration mechanism 1 includes a horizontally arranged infiltration tank body 11, a plurality of infiltration rings 12 are evenly distributed from bottom to top along the length direction of the infiltration tank body 11, the plurality of infiltration rings 12 are fixedly connected to the inner wall of the infiltration tank body 11, and atomizing nozzles 13 are evenly distributed in an annular shape and opened on the infiltration ring 12, a feeding tank body 17 is arranged above the infiltration tank body 11, a guide tank body 16 is arranged between the infiltration tank body 11 and the feeding tank body 17, and a nozzle 13 for breaking up the powder is arranged in the feeding tank body 17 The auxiliary mechanism 2 includes a mechanism tank body 21, an opening is provided on the mechanism tank body 21, a docking ring 22 is fixedly connected to the edge of the opening of the mechanism tank body 21, a docking groove 23 is provided on the docking ring 22, a powder raising fan 26 is provided in the mechanism tank body 21, and a powder raising motor 25 for driving the powder raising fan 26 to rotate is provided on the bottom surface of the mechanism tank body 21, the infiltration tank body 11 is sleeved on the docking groove 23 on the docking ring 22, the cover plate 3 is provided at the feeding place of the feed tank body 17, and a feed pipe 4 is embedded and penetrated on the end surface of the cover plate 3.

[0033] In some specific embodiments, an on-off valve 1 for controlling the on-off of the feed pipe 4 is fixedly installed on the feed pipe 4 , and an on-off valve 2 for controlling the on-off of the drain pipe 27 is fixedly installed on the drain pipe 27 .

[0034] The infiltration tank body 11 is cylindrical as a whole. For the convenience of description, the section passing through the central axis of the infiltration tank body 11 is defined as the cross section. The infiltration ring 12 protrudes on the inner wall surface of the infiltration tank body 11. The cross section of the infiltration ring 12 is trapezoidal. The two ends of the protruding part of the infiltration ring 12 smoothly transition to the inner wall surface of the infiltration tank body 11 to form a slope. The diameter of the feed tank body 17 is smaller than the diameter of the infiltration tank body 11. The guide tank body 16 is an inclined truncated cone tubular tank body arranged between the infiltration tank body 11 and the feed tank body 17.

[0035] A water inlet pipe 14 is evenly distributed in a ring on the outer end surface of the infiltration tank body 11, and a water distribution pipe 15 is embedded in the inner wall of the infiltration tank body 11. The water distribution pipes 15 are connected to the atomizing nozzles 13 on the infiltration ring 12, and the water inlet pipe 14 and the water distribution pipe 15 are connected. A fixed bracket 18 is fixedly connected to the inner wall of the water inlet pipe 14, a material distribution motor 19 is fixedly connected to the fixed bracket 18, an adapter 110 is fixedly connected to the driving end of the material distribution motor 19, material distribution baffles 111 are evenly distributed in a ring and fixedly connected to the side end surface of the adapter 110, and a connecting plate 112 is fixedly connected to the outer end surface of the infiltration tank body 11.

[0036] A connecting plate 24 corresponding to the connecting plate 1 112 is fixedly connected to the mechanism tank body 21, a connecting through hole is opened on the connecting plate 1 112, a threaded through hole is opened through the connecting plate 2 24, a bolt is threadedly connected between the connecting plate 1 112 and the connecting plate 2 24, and the bolt passes through the connecting through hole on the connecting plate 1 112 and is threadedly connected with the threaded through hole on the connecting plate 2 24.

[0037] In some specific implementation schemes, the powder raising motor 25 is embedded through and fixedly connected to the bottom surface of the mechanism tank 21, the driving end of the powder raising motor 25 is coaxially fixedly connected with a driving shaft, and the powder raising fan 26 is coaxially fixedly connected with the driving shaft.

[0038] In some specific implementation schemes, a drain pipe 27 is fixedly connected to the bottom of the mechanism tank body 21 , and the drain pipe 27 is connected to the interior of the mechanism tank body 21 .

[0039] A method for adding ingredients to valsartan production comprises the following steps:

[0040] Step 1: Open the on-off valve 1 on the feed pipe 4, add various raw material powders into the infiltration tank body 11 through the feed pipe 4, and start the material distribution motor 19 to drive the material distribution baffle 111 to rotate. The material distribution baffle 111 rotates to break up the raw material powder entering from the feed pipe 4. After the powder adding work is completed, close the on-off valve 1 on the feed pipe 4, so that the mechanism tank body 21 and the infiltration tank body 11 are airtightly arranged;

[0041] Step 2: Start the powder raising motor 25 to drive the powder raising fan 26 to rotate. The powder raising fan 26 rotates to raise all the raw material powder in the infiltration tank 11 and the mechanism tank 21, so that the raw material powder in the infiltration tank 11 and the mechanism tank 21 floats;

[0042] Step 3: Connect the water source to the water inlet pipe 14 evenly distributed on the outside of the infiltration tank 11, and the water flows through the water inlet pipe 14 and then through the water distribution pipe 15 to be dispersed to the atomizing nozzles 13 evenly distributed in an annular manner on the infiltration ring 12, and then sprayed out after being atomized, so as to evenly combine the atomized water mist with the floating powder in the infiltration tank 11 and the mechanism tank 21;

[0043] Step 4: A smooth transition is provided between the infiltration ring 12 and the inner wall surface of the infiltration tank body 11 and an inclined surface is provided so that the water flow can flow smoothly between the infiltration ring 12 and the surface of the infiltration tank body 11 to prevent the powder and water mist from agglomerating on the surface of the infiltration tank body 11.

[0044] In order to facilitate the understanding of the embodiments of this solution by those skilled in the art, the working principle of this solution is briefly described in combination with specific application scenarios:

[0045] When in use, the water inlet pipe 14 on the surface of the infiltration tank body 11 is connected to the water source, and the water flows through the water inlet pipe 14 and reaches the atomizing nozzle 13 on the infiltration ring 12 after passing through the water distribution pipe 15. The infiltration ring 12 is evenly distributed on the inner wall of the infiltration tank body 11 from bottom to top. At the same time, the atomizing nozzle 13 is evenly distributed in an annular shape on the infiltration ring 12, so that the water mist in the infiltration tank body 11 and the mechanism tank body 21 is more evenly distributed. At the same time, the material distribution baffle 111 is driven to rotate by the material distribution motor 19, and the material distribution baffle 111 can break up the powder sent into the infiltration tank body 11 and the mechanism tank body 21, and cooperate with the powder raising wind The fan 26 lifts up the divided materials in the mechanism tank body 21 and the infiltration tank body 11, and improves the infiltration effect of the powder by combining the flying powder in the infiltration tank body 11 with the water mist in the infiltration tank body 11. The infiltration ring 12 and the inner walls of the infiltration tank body 11 on both sides form an inclined surface by a smooth transition. After the water mist condenses on the surface of the infiltration ring 12 and the surface of the infiltration tank body 11, it will flow smoothly along the surface of the infiltration ring 12, the inner wall surface of the infiltration tank body 11 and the inclined surface between the infiltration ring 12 and the infiltration tank body 11, which can effectively prevent the flying dust in the infiltration tank body 11 and the water mist from agglomerating on the surface of the infiltration tank body 11.

[0046] Several embodiments of the present invention are described in detail above, but the embodiments of the present invention are not limited thereto and cannot be considered to limit the scope of implementation of the present invention. All equivalent changes and improvements made within the scope of the present invention should still fall within the scope of the patent coverage of the present invention.

Claims

1. A valsartan production ingredient adding device, characterized in that, include: The infiltration mechanism (1) comprises an infiltration tank (11) arranged horizontally, a plurality of infiltration rings (12) being evenly distributed from bottom to top along the length direction of the infiltration tank (11), the plurality of infiltration rings (12) being fixedly connected to the inner wall of the infiltration tank (11), atomizing nozzles (13) being evenly distributed in annular shapes on the infiltration rings (12), a feeding tank (17) being arranged above the infiltration tank (11), a flow guide tank (16) being arranged between the infiltration tank (11) and the feeding tank (17), a material distribution baffle (111) for dispersing material powder and a material distribution motor (19) for driving the material distribution baffle (111) to rotate being arranged in the feeding tank (17); The auxiliary mechanism (2) comprises a mechanism tank body (21), the upper end of the mechanism tank body (21) is provided with an opening, a docking ring (22) is fixedly connected to the edge of the opening of the mechanism tank body (21), a docking groove (23) is provided on the docking ring (22), a powder raising fan (26) is arranged in the mechanism tank body (21), a powder raising motor (25) for driving the powder raising fan (26) to rotate is arranged on the bottom surface of the mechanism tank body (21), and the infiltration tank body (11) is sleeved on the docking groove (23) on the docking ring (22); The cover plate (3) is arranged at the feeding place of the feeding tank body (17), and a feeding pipe (4) is embedded through the end surface of the cover plate (3).

2. A valsartan production ingredient adding equipment according to claim 1, characterized in that, An on-off valve 1 for controlling the on-off of the feed pipe (4) is fixedly mounted on the feed pipe (4), and an on-off valve 2 for controlling the on-off of the drain pipe (27) is fixedly mounted on the drain pipe (27).

3. A valsartan production ingredient adding equipment according to claim 1, characterized in that, The infiltration tank body (11) is cylindrical in shape as a whole, the infiltration ring (12) is protrudingly arranged on the inner wall surface of the infiltration tank body (11), the cross section of the infiltration ring (12) is trapezoidal, the two ends of the protruding part of the infiltration ring (12) and the inner wall surface of the infiltration tank body (11) smoothly transition to form a slope, the pipe diameter of the feed tank body (17) is smaller than the pipe diameter of the infiltration tank body (11), and the guide tank body (16) is an inclined truncated cone-shaped tubular tank body arranged between the infiltration tank body (11) and the feed tank body (17).

4. A valsartan production ingredient adding equipment according to claim 1, characterized in that, A water inlet pipe (14) is evenly distributed in a ring shape on the outer end surface of the infiltration tank body (11), and a water distribution pipe (15) is embedded on the inner wall of the infiltration tank body (11). The water distribution pipe (15) is connected to the atomizing nozzle (13) on the infiltration ring (12), and the water inlet pipe (14) and the water distribution pipe (15) are connected to each other.

5. A valsartan production ingredient adding device according to claim 4, characterized in that, A fixed bracket (18) is fixedly connected to the inner wall of the water inlet pipe (14), a material distribution motor (19) is fixedly connected to the fixed bracket (18), an adapter (110) is fixedly connected to the driving end of the material distribution motor (19), material distribution baffles (111) are evenly distributed in an annular shape and fixedly connected to the side end surface of the adapter (110), and a connecting plate 1 (112) is fixedly connected to the outer end surface of the infiltration tank body (11).

6. A valsartan production ingredient adding equipment according to claim 5, characterized in that, A second connecting plate (24) corresponding to the first connecting plate (112) is fixedly connected to the mechanism tank body (21); a connecting through hole is provided on the first connecting plate (112); a threaded through hole is provided through the second connecting plate (24); a bolt is threadedly connected between the first connecting plate (112) and the second connecting plate (24); the bolt passes through the connecting through hole on the first connecting plate (112) and is threadedly connected to the threaded through hole on the second connecting plate (24).

7. A valsartan production ingredient adding equipment according to claim 1, characterized in that, The powder raising motor (25) is embedded through and fixedly connected to the bottom surface of the mechanism tank (21), the driving end of the powder raising motor (25) is coaxially fixedly connected to a driving shaft, and the powder raising fan (26) is coaxially fixedly connected to the driving shaft.

8. A method for adding ingredients to a valsartan production equipment according to any one of claims 1 to 7, characterized in that: The steps include: Step 1: Open the on-off valve 1 on the feed pipe (4), add various raw material powders into the infiltration tank body (11) through the feed pipe (4), and at the same time start the material distribution motor (19) to drive the material distribution baffle (111) to rotate, so that the material distribution baffle (111) rotates to break up the raw material powder entering from the feed pipe (4). After the powder adding work is completed, close the on-off valve 1 on the feed pipe (4), so that the mechanism tank body (21) and the infiltration tank body (11) are sealed. Step 2: starting the powder raising motor (25) to drive the powder raising fan (26) to rotate, and the powder raising fan (26) rotates to raise all the raw material powder in the infiltration tank (11) and the mechanism tank (21), so that the raw material powder in the infiltration tank (11) and the mechanism tank (21) floats; Step 3: Connect a water source to the water inlet pipe (14) evenly distributed outside the infiltration tank (11), and the water flows through the water inlet pipe (14) and then through the water distribution pipe (15) to the atomizing nozzles (13) evenly distributed in an annular shape on the infiltration ring (12), and then sprayed out after being atomized, so that the atomized water mist is evenly combined with the floating powder in the infiltration tank (11) and the mechanism tank (21); Step 4: A smooth transition is formed between the infiltration ring (12) and the inner wall surface of the infiltration tank body (11) and an inclined surface is provided, so that water can flow smoothly between the infiltration ring (12) and the surface of the infiltration tank body (11), thereby preventing powder and water mist from agglomerating on the surface of the infiltration tank body (11).

Images