The invention relates to a life-cycle water-free cooling solution which is characterized by comprising the following components in percent by weight: 10-50 percent of propylene glycol, 50-80 percent of ethylene glycol, 0.1-10 percent of triazole compounds, 0.5-3.0 percent of sebacic acid, 0.2-1.0 percent of adipic acid, 0.5-1.5 percent of sodium benzoate, 0.3-5 percent of inorganic base, 0.01-0.1 percent of antifoaming agent and 0.01-0.1 percent of colouring agent. The cooling solution has a freezing point of below -50 DEG C and a boiling point of 166-191 DEG C; and because the cooling solution does not contain water, problems of boiling, gas etching, evaporating, scaling, rusting and the like caused by water existing in the cooling solution are thoroughly eliminated, a steam air resistance layer seriously influencing heat radiation is avoided from generating, power of an engine can be effectively improved and fuel is saved. Because the cooling solution does not contain water and has a reasonable corrosion inhibition system, the problem of corrosion is thoroughly solved; and the cooling solution has a service life of reaching up to 8 hundred thousand kilometers, is added once without replacement, is a life-cycle cooling solution, is especially suitable for military vehicles, high-end vehicles and high-power heavy-loading trucks and passenger cars, and can ensure that the vehicles safely run under extremely hot weather, severe cold weather, and severe environments such as desert, plateau, snowfield and the like.