Microneedle patch having improved deformability and microneedle patch kit comprising same

Abstract

The present invention relates to a microneedle patch comprising: a microneedle array comprising a central portion and a plurality of peripheral portions connected to the central portion and surrounding the central portion, the peripheral portions comprising adjacent peripheral portions arranged at intervals, the microneedle array comprising a planar hard base material and a plurality of microneedles located on the hard base material, according to the present invention, a gap between adjacent peripheral parts is folded, so that the adhesive tape can be attached with high adhesive force even at a curved affected part.

Description

Technical Field

[0001] The present invention relates to a microneedle patch with improved deformability and a microneedle patch set comprising the same. Background Art

[0002] Skin problems are caused by various factors such as stress, eating habits, seasonal changes, wearing masks, etc., so products that alleviate the problems are being developed. The problem is that too much sebum is secreted from the sebaceous glands inside the pores, which clogs the pores, where bacteria proliferate and cause inflammation, and a protruding surface like a bump is formed and generated toward the outside of the skin. Since this problem mostly occurs on the face, there is an increasing demand for a treatment method that is quick, reliable, and easy for anyone to apply from a beauty perspective.

[0003] As products for improving skin problems, there are various types of products such as skin care products, facial cleansers, patches, and ointments. Among them, patches include multiple microneedles, so they can provide the effect of delivering drugs and regenerating skin to local parts. However, most microneedle patches are relatively soft, so when the patches are attached to the face with large movements, the patches may easily fall off the skin surface. In addition, when the patches are attached to curved parts with skin problems such as acne, the adhesion and bonding strength of the patches are reduced, and only a part of the microneedles contained in the patches are inserted into the affected area, so there is a problem that the treatment effect of skin problems is significantly reduced.

[0004] Therefore, it is necessary to develop a microneedle patch that can be attached with high adhesion even to a curved affected area. Summary of the invention

[0005] Technical issues

[0006] The object of the present invention is to solve the problems of the prior art and to provide a microneedle patch having improved deformability and capable of being attached with high adhesion even to a curved affected area, and a microneedle patch set including the same.

[0007] Another object of the present invention is to provide a microneedle patch in which microneedles can be uniformly inserted into the central part and the peripheral part of a protruding affected part, and a microneedle patch set including the same.

[0008] Solution to the problem

[0009] The microneedle patch according to the present invention comprises: a microneedle array, the microneedle array comprising: a planar hard substrate; a plurality of microneedles located on the hard substrate, the microneedle array comprising a central portion, and a plurality of peripheral portions connected to and surrounding the central portion, the peripheral portions being arranged at intervals from adjacent peripheral portions, and being folded through the gaps between the adjacent peripheral portions.

[0010] The microneedle patch according to the present invention may further include a soft substrate located below the microneedle array.

[0011] According to the microneedle patch of the present invention, the gap may be a plane portion having a step difference with the microneedle array.

[0012] According to the microneedle patch of the present invention, the gap can expose the upper surface of the soft substrate.

[0013] According to the microneedle patch of the present invention, the upper surface of the soft substrate may be adhesive.

[0014] According to the microneedle patch of the present invention, the area of ​​the peripheral portion may be larger than the area of ​​the gap between the adjacent peripheral portions.

[0015] According to the microneedle patch of the present invention, the outer peripheral surface of the central portion adjoining the gap may be rounded.

[0016] The microneedle patch according to the present invention may further include a protective film located on the microneedle patch.

[0017] According to the microneedle patch of the present invention, the soft substrate may include a hydrocolloid layer.

[0018] According to the microneedle patch of the present invention, the microneedle array may contain a biocompatible polymer.

[0019] According to the microneedle patch of the present invention, the microneedle array may contain an active ingredient.

[0020] According to the microneedle patch of the present invention, the central portion is in contact with the protruding affected area, and the peripheral portion wraps around and is in contact with the peripheral portion of the affected area.

[0021] The present invention includes a microneedle patch kit containing the above-mentioned microneedle patch.

[0022] The microneedle patch kit according to the present invention comprises: a release film; and a plurality of microneedle patches spaced apart on the release film.

[0023] The microneedle patch kit according to the present invention may further include a protective film that covers and protects the plurality of release films and the plurality of microneedle patches.

[0024] According to the microneedle patch kit of the present invention, the release film may include a dividing line formed along one direction.

[0025] According to the microneedle patch kit of the present invention, a plurality of microneedle patches may be located on the dividing line.

[0026] According to the microneedle patch kit of the present invention, the release film further comprises a plurality of microneedle patch accommodating portions positioned at intervals from the dividing line, and a plurality of microneedle patches can be individually packaged by the microneedle patch accommodating portions.

[0027] Effects of the Invention

[0028] The microneedle patch according to the present invention can be attached with high adhesion even to a curved affected area.

[0029] In addition, a microneedle patch and a microneedle patch set including the same can be provided, wherein the microneedles are uniformly inserted into the center and the periphery of the affected area, thereby improving the treatment effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 1 is a plan view and a side view showing a microneedle patch according to a first embodiment of the present invention;

[0031] Figure 2 2 are a plan view and a side view showing a microneedle patch according to a second embodiment of the present invention;

[0032] Figure 3 is a schematic diagram showing the application of a microneedle patch according to a first embodiment of the present invention to a human body;

[0033] Figure 4 is a plan view showing a microneedle patch according to third and fourth embodiments of the present invention;

[0034] Figure 5 is a plan view showing a microneedle patch kit according to an embodiment of the present invention;

[0035] Figure 6 is a plan view showing a microneedle patch kit according to another embodiment of the present invention;

[0036] Figure 7 It is shown Figure 1 The schematic diagram of the cross section of the microneedle patch when attached to the protruding affected area;

[0037] Figure 8 It is measured Figure 1 Confocal image of the fluorescent material delivery distribution of the microneedle patch is shown. DETAILED DESCRIPTION

[0038] The microneedle patch with improved deformability of the present invention and the microneedle patch kit including the same will be described in detail below. The terms used in this specification are general terms that are currently used as widely as possible while considering the functions of the present invention, but this may change according to the intentions of technicians working in related fields or precedents, the emergence of new technologies. Unless otherwise defined, the technical and scientific terms used may have the meanings commonly understood by technicians in the technical field to which the present invention belongs.

[0039] As used in this specification and the appended claims, singular expressions include plural expressions unless the context clearly indicates the singular. In addition, plural expressions include singular expressions unless the context clearly indicates the plural.

[0040] In this specification and the appended claims, terms such as “comprising” or “having” mean the presence of features or components described in the specification, and, unless specifically limited, do not exclude the possibility of adding one or more other features or components.

[0041] In addition, the numerical range used in this specification includes the lower limit and the upper limit and all values ​​within the range, the increment theoretically derived from the form and width of the defined range, all values ​​of the double definition, and all possible combinations of the upper limit and the lower limit of the numerical range defined in different forms. Unless otherwise specified in the present specification, values ​​outside the numerical range that may appear due to experimental errors or rounding of numerical values ​​are also included in the defined numerical range.

[0042] In this specification and the appended claims, the terms "about" and the like are used in a sense that when there is a permissible error, the permissible error is included.

[0043] Since the microneedle patch including a plurality of microneedles in the prior art has poor softness, when the microneedle patch is attached to a protruding curved affected part, as only a portion of the microneedles are inserted into the affected part, there is a problem that the amount of drug delivered to the affected part is reduced and the therapeutic effect is reduced. In addition, when the microneedle patch is attached to the face with greater mobility, there is a problem that the adhesion is low and the microneedle patch is easily detached from the skin.

[0044] Based on this, the applicant has conducted in-depth research and developed a microneedle patch that can evenly insert microneedles into the center and periphery of a protruding affected area through a microneedle patch with high deformability, thereby improving adhesion and providing excellent drug delivery effect and inflammation relief effect.

[0045] Figure 1 A microneedle patch 100 according to an embodiment of the present invention is shown.

[0046] Reference Figure 1The microneedle patch 100 according to the present invention may include a microneedle array 10 and a soft substrate located at the bottom of the microneedle array, wherein the microneedle array 10 includes a hard substrate 14 and a plurality of microneedles 13 located on the hard substrate 14.

[0047] The microneedle array 10 includes a central portion 11 and a plurality of peripheral portions 12 connected to and surrounding the central portion 11. The peripheral portion 12 is characterized in that adjacent peripheral portions 121, 122 are arranged at intervals from each other and are folded through gaps 20 between the adjacent peripheral portions 121, 122.

[0048] like Figure 1 As shown, by providing a gap 20 between the peripheral portion 121 of the microneedle array 10 and the adjacent peripheral portion 122, the deformability of the microneedle patch 100 can be improved. When the microneedle patch 100 is attached to a curved affected area, the microneedle array 10 with low flexibility can be easily folded through the gap 20 to improve the adhesion. The microneedle array 10 can be folded and attached to the affected area due to its high deformability, and the number of microneedles 13 inserted into the protruding affected area can be increased. As a result, the active ingredients contained in the microneedle array 10 are evenly delivered to the entire affected area through the microneedles 13, which can improve the treatment effect.

[0049] The so-called active ingredient is an ingredient that provides direct or indirect effects by showing the pharmacological effects of the ingredient, and the active ingredient can provide the effects of reducing sebum secretion, antibacterial, anti-inflammatory, and wound treatment. When the microneedle 13 is inserted into the affected area, the active ingredient can be quickly delivered to the local area through the microneedle 13, thereby manufacturing a microneedle patch 100 with excellent treatment effects on the affected area.

[0050] In a specific example, the number of the peripheral portions 20 may be 2 to 20 or 2 to 10, preferably 2 to 6. Within the above range, the microneedle patch 100 exhibits high deformability and can wrap the affected area with excellent adhesion, but the present invention is not limited thereto.

[0051] The area of ​​the peripheral portion 12 may be larger than the area of ​​the gap 20 between the adjacent peripheral portions 12. The area of ​​the peripheral portion 12 is larger than the area of ​​the gap 20, so that the microneedle 13 can be inserted as a whole while wrapping the peripheral portion of the affected area. The area of ​​the peripheral portion 12 refers to the area separated from the central portion by a straight line connecting the innermost end of the gap 20 and the innermost end of the adjacent gap 20. In addition, the area of ​​the gap 20 refers to the area of ​​a closed curve formed by the shortest distance connecting the outermost circumferential surface of the peripheral portion 12 and the outermost circumferential surface of the adjacent peripheral portions 12 with a straight line.

[0052] like Figure 1As shown, the soft substrate 30 is located below the microneedle array 10, thereby imparting flexibility to the microneedle patch 100. In addition, since the upper surface of the soft substrate 30 is sticky, the microneedle patch 100 including the microneedle array 10 with low flexibility can also be attached to a curved affected area for a long time.

[0053] The gap 20 is a plane portion having a step difference with the hard substrate 14 of the microneedle array 10, and can expose the upper surface of the soft substrate 30. The soft substrate 30 having adhesiveness is exposed in the gap 20 between the adjacent peripheral portions 12 of the microneedle patch 100, thereby improving the adhesion of the microneedle patch 100.

[0054] Specifically, the central portion 11 of the microneedle array 10 is connected to the protruding affected part, and the peripheral portion 12 of the microneedle array 10 can wrap and connect to the peripheral portion of the affected part. As the number of microneedles 13 inserted into the affected part increases, the delivery effect of the active ingredient through the microneedles 13 and the treatment effect of the affected part can be improved.

[0055] In particular, the central portion 11 of the microneedle array 10 includes microneedles 13, and the microneedles 13 can be inserted into the central portion of the affected part while the central portion of the protruding affected part is in contact with the central portion 11 of the microneedle array 10. By inserting the microneedles 13 into the central portion of the affected part where the amount of exudate discharged is large, exudates such as sore water and pus can be quickly absorbed, thereby further improving the effect of relieving inflammation of the affected part.

[0056] The plurality of microneedles 13 may be arranged at intervals on the hard substrate 14. Specifically, the microneedle 13 is a needle-like structure whose width decreases as it moves away from the hard substrate 14, and can be inserted into the affected area through a sharp tip at the end of the microneedle 13. Without limitation, the length of the microneedle 13 may be 100 to 1000 μm or 200 to 800 μm, and may be 300 to 600 μm in practical terms.

[0057] Figure 2 A microneedle patch 200 according to another embodiment of the present invention is shown.

[0058] Reference Figure 2 The outer peripheral surface 11a of the central portion 11 of the microneedle patch 200 that is connected to the gap 20 can be rounded. During the manufacturing process of the microneedle patch 100 or when the microneedle patch 100 is used, the problem of cracking and damage of the hard microneedle array 10 can be minimized.

[0059] According to a non-limiting embodiment, the manufacturing method of the microneedle patch 100 is: after manufacturing the microneedle array 10 of a shape corresponding to the central portion 11, a portion of the microneedle array 10 is cut from the peripheral surface of the central portion 11 along the direction of the peripheral surface of the microneedle array 10, so that the gap 20 can be formed. As a more specific example, in the case of manufacturing the microneedle patch 100 in which the central portion 11 is circular, after using a mold to manufacture a hard substrate 14 and a circular microneedle array 10 including a plurality of microneedles 13 located on the hard substrate 14, a portion of the microneedle array 10 other than the central portion 11 is cut with a blade or a laser, so that the gap 20 and the plurality of peripheral portions 12 can be formed. The peripheral surface of the central portion 11 connected to the gap 20 can be sharply cut into a V shape or cut into a U shape and rounded, so that the microneedle patch 100 can be manufactured.

[0060] According to another non-limiting embodiment, a pattern corresponding to the microneedle array 10 is formed in the mold, and a microneedle patch 100 including a gap 20 between the peripheral portion 122 adjacent to the peripheral portion 121 can be manufactured. Specifically, the mold may include a plurality of concave grooves corresponding to the microneedles 13 and a convex pattern corresponding to the gap 20. The microneedle array 10 is formed using the mold, and after the soft substrate 30 is attached to the microneedle array 10, the microneedle array 10 is separated from the mold, and a microneedle patch 100 including a gap 20 between the peripheral portion 122 adjacent to the peripheral portion 121 can be manufactured.

[0061] Figure 3 Schematic diagram showing the microneedle patch 100 according to one embodiment of the present invention being attached to an affected area of ​​facial skin of a human body.

[0062] Reference Figure 3 The microneedle patch 100 of the present invention is formed with the upper surface of the microneedle array 10 in contact with the human skin, and the microneedles are inserted into the affected part and attached. At this time, the lower surface of the microneedle patch 100 where the soft substrate 30 is located is exposed to the outside. When the microneedle patch 100 is attached to the affected part, the microneedle array 10 is deformed into a shape corresponding to the surface of the affected part as the gap 20 is formed, and can be closely attached to the affected part. That is, the gap 20 can play the role of a gap of the microneedle array 10.

[0063] Reference Figure 3 The upper surface of the microneedle patch 100 in contact with the affected part has both the area where the microneedle array 10 is located and the area of ​​the soft substrate 30 exposed through the gaps 20 of the microneedle array 10. In addition, in order to improve the adhesion of the microneedle patch 100 to the affected part, the soft substrate 30 with adhesiveness on the upper surface has an area larger than the microneedle array 10, so that a portion of the upper surface with adhesiveness of the soft substrate can be exposed along the edge of the microneedle array 10.

[0064] Figure 4Various shapes of the central portion 11 and the peripheral portion 12 of the central portion 11 are shown as microneedle patches 300 and 400 according to still another embodiment of the present invention.

[0065] The shape of the center portion 11 of the microneedle patch 100 is not particularly limited as long as it can be attached to the affected area. The center portion 11 of the microneedle patch 100 may be a plane shape with curved edges such as a circle or an ellipse. Alternatively, it may be a plane shape with straight edges such as a triangle, a quadrilateral or a rectangle. Alternatively, Figure 4 That is, the shape of the microneedle patch 100 is not particularly limited, as long as the central portion 11 and the peripheral portion 12 are formed, and according to the location where the microneedle patch 100 is attached, the microneedle patch 100 with the central portion 11 and the peripheral portion 12 having appropriate shapes can be used to improve the adhesion.

[0066] In order to prevent the unused microneedle patch 100 from being exposed to pollutants, a protective film 40 may be further included on the microneedle patch 100. By preventing pollutants such as foreign matter, bacteria and viruses from entering from the outside from penetrating into the microneedle patch 100, the risk of contamination of the affected area and secondary infection is prevented, so that the microneedle patch 100 can be used more hygienically.

[0067] In one embodiment, the soft substrate 30 may include a hydrocolloid layer. The soft substrate 30 including the hydrocolloid layer seals the affected area, prevents foreign matter such as bacteria from penetrating into the affected area, absorbs exudates, and can protect and seal the affected area.

[0068] In one embodiment, the microneedle array 10 may contain biocompatible polymers. Biocompatible polymers may include hyaluronic acid, lipids, chitosan, proteins, DNA, collagen, alginic acid, gelatin, silk fibroin, poly(lactic-co-glycolic acid) copolymer (PLGA), polylactic acid (PLA), polyvinyl polypyrrolidone (PVP), polyvinyl alcohol (PVA), sucrose, maltose, polyethylene, SU-8, polymethylmethacrylate (PMMA), polycarbonate, poly(methyl vinyl ether-co maleic anhydride, PMVE / MA), sodium chondroitin sulfate, sulfate), polycaprolactone (PCL), polyethylene glycol polymer (Poly (ethylene glycol)), polyacrylic acid (Poly acrylic acid, PAA), γ-polyglutamic acid (Poly-γ-glutamic acid), etc., preferably, hyaluronic acid (hyaluronic acid). As a specific example, the microneedles 13 and the hard substrate 14 included in the microneedle array 10 may include the same or different substances, preferably the same substance.

[0069] The present invention provides a microneedle patch set 1 including the microneedle patch 100 described above.

[0070] The microneedle patch set 1 according to the present invention comprises: a release film 50; and a plurality of microneedle patches 100 spaced apart from each other on the release film 50. Since the microneedle patches are the same as those described above, a detailed description thereof will be omitted.

[0071] like Figure 5As shown, the release film 50 may include a dividing line 60 formed in one direction, and a plurality of microneedle patches 100 are arranged on the dividing line 60, so that the microneedle patches 100 are separated from the release film 50 and can be conveniently used. When the microneedle patch 100 is peeled off from the release film 50, the microneedle patch 100 may not come into contact with a contaminated hand. By preventing contamination of the patch, infection of the affected area caused by the microneedle patch 100 can be prevented.

[0072] In order to prevent the microneedle patch 100 from being exposed to contamination, a protective film 40 may be further included to cover and protect the release film 50 and the plurality of microneedle patches 100. As described above, the protective film 40 may hygienically and safely protect the microneedle patch 100 from external contaminants such as foreign matter, bacteria, and viruses.

[0073] In one embodiment, the release film 50 and the protective film 40 may include a transparent plastic film such as polyethylene terephthalate (PET), polypropylene (PP) or polyethylene (PE), and preferably may include polyethylene terephthalate (PET), but the present invention is not limited thereto.

[0074] In another aspect of the present invention, referring to Figure 6 The microneedle patch set 2 further includes a plurality of microneedle patch receiving portions 70 spaced apart from the dividing line 60, and a plurality of microneedle patches 100 can be individually packaged according to the dividing line 60. The microneedle patch set 2 in which the microneedle patches 100 are individually packaged is sealed by the recessed microneedle patch receiving portions 70, so that the unused microneedle patches 100 are not exposed to the external environment, thereby facilitating the prevention of the penetration of pollutants and moisture.

[0075] Specifically, the individually packaged microneedle patch 100 has a release paper attached to the upper surface of the soft substrate 30, that is, the adhesive surface, so that the microneedle patch 100 can be used hygienically while maintaining the adhesive force of the soft substrate 30. The release paper has a separation line cut in one direction, so that when the microneedle patch 100 is used, the release paper can be easily separated from the soft substrate 30.

[0076] The present invention will be described in more detail below by way of examples.

[0077] (Example 1)

[0078] Polydimethylsiloxane (PDMS) is molded in an aluminum master mold to produce a mold including a plurality of concave grooves corresponding to the microneedles. Subsequently, hyaluronic acid is molded in the PDMS mold and a microneedle array is produced by curing. A hydrocolloid layer is attached to the microneedle array as a soft substrate. At this time, the adhesive surface of the hydrocolloid layer is positioned so as to be in contact with the microneedle array. Then, the microneedle array including the soft substrate is separated from the PDMS mold, and the peripheral portion of the microneedle array is cut with a laser to form a gap to produce a microneedle array such as Figure 1 The microneedle patch shown.

[0079] (Example 2)

[0080] The microneedle array was manufactured in the same manner as in Example 1 except that a blade was used for cutting.

[0081] (Example 3)

[0082] The microneedle patch was prepared in the same manner as in Example 1, but when the microneedle array was cut, the outer peripheral surface of the central portion connected to the gap was rounded to prepare a microneedle patch. Figure 2 The microneedle patch shown.

[0083] (Comparative Example 1)

[0084] A microneedle patch was prepared in the same manner as in Example 1 except that the microneedle array was not cut.

[0085] Figure 7 1 is a view showing a cross section when the microneedle patch manufactured by the method of Example 1 and Comparative Example 1 is attached to the protruding problem. The microneedle patch of Example 1 is easily folded by the gap between the peripheral portion and the adjacent peripheral portion. The deformability of the microneedle patch is improved, so that the microneedle is inserted not only in the center of the affected part, but also in the peripheral portion. However, the microneedle patch of Comparative Example 1 does not prepare a space for the microneedle array to be folded, so the deformability is reduced, and only a part of the microneedles included in the microneedle array is inserted into the affected part, and the microneedle is not inserted into the peripheral portion of the affected part, so the adhesion is reduced.

[0086] Figure 8 The images are for evaluating the drug delivery effects of the microneedle patches manufactured by the methods of Example 1 and Comparative Example 1. The microneedle patches injected with the fluorescent dye rhodamine B were attached to pig skin simulating a protruding affected area, and the effects were compared by confocal imaging.

[0087] like Figure 8As shown, in the case of the microneedle patch of Comparative Example 1, it can be seen that the fluorescent material is only delivered to the center and a portion of the peripheral portion of the protruding affected part, and the drug is unevenly delivered to the protruding part. On the contrary, in the case where the fluorescent microneedle patch of Example 1 is attached to the protruding affected part, the fluorescent material is uniformly delivered to the center and the peripheral portion of the affected part. Not only the center of the protruding affected part is wrapped, but also the peripheral portion is wrapped and tightly attached, so that all the microneedles included in the microneedle array are uniformly inserted into the affected part. It can be determined that by improving the deformability of the microneedle patch, the microneedles are uniformly inserted into the center and the peripheral portion of the affected part, thereby realizing a microneedle patch that effectively delivers active ingredients to the local part.

[0088] As described above, the present invention has been described through specific details, limited embodiments and drawings, but they are only provided to help a more comprehensive understanding of the present invention, and the present invention is not limited to the above embodiments, and technicians in the technical field to which the present invention belongs can make various modifications and variations to this specification.

[0089] Therefore, the idea of ​​the present invention should not be limited to the described embodiments, and not only the claims described below, but also all matters having equivalent or equivalent modifications to the scope of the claims fall within the scope of the present invention.

Claims

1. A microneedle patch, comprising a microneedle array, The microneedle array comprises: Flat hard substrate; A plurality of microneedles are located on the hard substrate. The microneedle array includes a central portion and a plurality of peripheral portions connected to and surrounding the central portion. The peripheral portion is spaced apart from adjacent peripheral portions and is folded through a gap between the adjacent peripheral portions.

2. The microneedle patch according to claim 1, further comprising: The soft substrate is located below the microneedle array.

3. The microneedle patch according to claim 1, wherein The gap is a plane portion having a step difference with the microneedle array.

4. The microneedle patch according to claim 2, wherein: The gap exposes the upper surface of the soft substrate.

5. The microneedle patch according to claim 2, wherein: The upper surface of the soft substrate is sticky.

6. The microneedle patch according to claim 1, wherein: The area of ​​the peripheral portion is larger than the area of ​​a gap between the peripheral portions adjacent to each other.

7. The microneedle patch according to claim 1, wherein The outer peripheral surface of the center portion adjoining the gap is rounded.

8. The microneedle patch according to claim 1, further comprising: A protective film is located on the microneedle patch.

9. The microneedle patch according to claim 5, wherein: The soft substrate includes a hydrocolloid layer.

10. The microneedle patch according to claim 1, wherein: The microneedle array contains biocompatible polymers.

11. The microneedle patch according to claim 1, wherein: The microneedle array contains an active ingredient.

12. The microneedle patch according to claim 1, wherein: The central portion is connected to the protruding affected area, and the peripheral portion wraps around and is connected to the peripheral portion of the affected area.

13. A microneedle patch kit, comprising: Release film; as well as A plurality of microneedle patches are spaced apart on the release film. The microneedle patch includes the microneedle patch according to any one of claims 1 to 12.

14. The microneedle patch kit according to claim 13, further comprising: A protective film covers and protects the multiple release films and the multiple microneedle patches.

15. The microneedle patch kit according to claim 13, wherein: The release film includes a dividing line formed along a direction.

16. The microneedle patch kit according to claim 15, wherein: A plurality of microneedle patches are located on the dividing line.

17. The microneedle patch kit according to claim 15, wherein: The release film further comprises: A plurality of microneedle patch receiving portions are positioned at intervals from the dividing line, A plurality of microneedle patches are individually packaged by the microneedle patch housing.

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