Amine-gold-yellow sensitive particles and production process thereof

Abstract

The invention provides ammonia-gold-yellow sensitive particles and a production process thereof. The paracetamol, chlorpheniramine maleate and amantadine hydrochloride granules are prepared from the following raw materials in parts by weight: 100 to 160 parts of paracetamol, 1.8 to 2.2 parts of chlorpheniramine maleate, 9 to 11 parts of calculus bovis factitius, 45 to 55 parts of amantadine hydrochloride, 500 to 1700 parts of cane sugar, 100 to 150 parts of pulping cane sugar, 14 to 18 parts of corn starch and 5 to 7 parts of strawberry essence. Secondly, the invention also provides an ammonia-gold-yellow sensitive particle, which is prepared by adding composite sugar or / and a composite extract on the basis of the prescription. The complex sugar is prepared from xylooligosaccharide, L-arabinose and yeast beta-glucan according to the mass ratio of (18 to 22) to (25 to 35) to (45 to 55); the compound plant extract is prepared from radix astragali, rhizoma atractylodis macrocephalae and radix paeoniae rubra in a mass ratio of (30-40): (50-60): (10-20). The ammonia-gold-yellow sensitive particles prepared by adopting the specific process conditions have a certain inhibition effect on influenza viruses, the anti-influenza effect is good, and the stability of the ammonia-gold-yellow sensitive particles prepared by adopting the preparation method is good.

Description

Technical Field

[0001] The invention relates to the field of pharmaceutical preparations, and in particular to a kind of aminoacid gold sensitive granules and a production process thereof. Background Art

[0002] Aminogen Glucoside Granules are a compound preparation, and the raw materials contain acetaminophen, amantadine hydrochloride, artificial bezoar and chlorpheniramine maleate. It is suitable for relieving fever, headache, limb pain, sneezing, runny nose, nasal congestion, sore throat and other symptoms caused by common cold and influenza in children. Influenza is caused by influenza virus, which includes influenza A virus, influenza B virus and influenza C virus. The existing Aminogen Glucoside Granules have poor therapeutic effect on colds caused by influenza viruses. Therefore, in order to improve its therapeutic effect, it is of great significance to further study the prescription and process of Aminogen Glucoside Granules. Summary of the invention

[0003] In view of this, the present invention proposes an ammonia gold sensitive granule and a production process thereof.

[0004] The technical solution of the present invention is achieved as follows: a production process of ammonia golden yellow sensitive granules, the ammonia golden yellow sensitive granules comprising the following raw materials in parts by weight: 100-160 parts of acetaminophen, 1.8-2.2 parts of chlorpheniramine maleate, 9-11 parts of artificial bezoar, 45-55 parts of amantadine hydrochloride, 500-1700 parts of sucrose, 100-150 parts of pulped sucrose, 14-18 parts of corn starch, and 5-7 parts of strawberry essence; the production process of the ammonia golden yellow sensitive granules comprises the following steps:

[0005] (1) adding slurry sucrose to purified water in a sandwich pot, boiling, filtering, adding purified water to prepare a syrup adhesive, cooling, and setting aside;

[0006] (2) artificial bezoar and chlorpheniramine maleate are mixed evenly, and corn starch, amantadine hydrochloride, and acetaminophen are added respectively according to the principle of equal amounts, and each material is shaken and sieved to mix evenly;

[0007] (3) crushing sucrose into sucrose powder, adding the mixed materials and sucrose powder into a wet granulator, turning on the stirring and cutting blades to mix the raw and auxiliary materials evenly;

[0008] (4) Add the syrup binder into the wet granulator, mix at a low speed first, then turn on the cutter and cut at a high speed to make a soft material;

[0009] (5) Pour the soft material into a swing granulator or a double-roll swing granulator for granulation;

[0010] (6) placing the granules after swing granulation in a high-efficiency fluidized bed dryer for drying, cooling, and discharging;

[0011] (7) sieving and sizing the dried granules, and collecting the sizing granules;

[0012] (8) Pour the whole granules and strawberry essence into a mixer and start mixing.

[0013] Furthermore, the mass concentration of the syrup adhesive in step (1) is 65-75%.

[0014] Furthermore, in step (4), the rotation speed of the low-speed mixing is 20-30 rpm, and the time of the low-speed mixing is 100-150 seconds; the rotation speed of the high-speed cutting is 200-300 rpm, and the time of the high-speed cutting is 40-60 seconds.

[0015] Furthermore, in step (6), the drying temperature is 55-65° C. and the drying time is 10-20 minutes. In step (8), the mixing speed is set to 30-50 Hz and the mixing time is set to 15-25 minutes.

[0016] The present invention also provides a production process of ammonia golden yellow sensitive granules comprising the following steps:

[0017] (1) Adding slurry sucrose to purified water in a sandwich pot, boiling for 15-25 minutes, filtering with a 200-mesh screen, adding purified water to prepare a syrup adhesive with a concentration of 65-75%wt, cooling to below 40°C, and setting aside;

[0018] (2) artificial bezoar and chlorpheniramine maleate are mixed evenly, and corn starch, amantadine hydrochloride, and acetaminophen are added respectively according to the principle of equal amounts, and each material is shaken through an 80-mesh sieve to mix evenly;

[0019] (3) crushing sucrose into sucrose powder, adding the mixed materials and sucrose powder into a wet granulator, turning on the stirring and cutting knife for 8-12 minutes to mix the raw materials and auxiliary materials evenly;

[0020] (4) Add the syrup binder into the wet granulator, mix at a low speed for 100-150 seconds, then turn on the cutter and cut at a high speed for 40-60 seconds to make a soft material;

[0021] (5) The soft material is poured into a swing granulator or a double-roll swing granulator and granulated by swinging through a 24-mesh sieve;

[0022] (6) The granules after swing granulation are placed in a high-efficiency fluidized bed dryer for drying at a temperature of 55-65° C. for 10-20 minutes. During the drying process, the bags are shaken once every 1.5-2.5 minutes. The granules are discharged when the temperature drops below 40° C.;

[0023] (7) The dried granules are sieved through a linear sieve with an upper layer of 20 mesh and a lower layer of 60 mesh. The coarse granules that cannot pass through are put into a swing granulator and sized using a 22-mesh sieve, and the sized granules are collected;

[0024] (8) After granulation, the qualified granules and strawberry essence are poured into a square cone mixer, the mixing speed is set to 30-50 Hz, the mixing time is set to 15-25 minutes, and the mixer is started for mixing.

[0025] Furthermore, the invention also contains complex sugar, which is composed of oligoxylose, L-arabinose and yeast β-glucan in a mass ratio of 18-22:25-35:45-55; in parts by weight, the invention comprises 145-155 parts of acetaminophen, 1.8-2.2 parts of chlorpheniramine maleate, 9-11 parts of artificial bezoar, 45-55 parts of amantadine hydrochloride, 500-700 parts of sucrose, 100-150 parts of pulping sucrose, 14-18 parts of corn starch, 5-7 parts of strawberry essence and 150-250 parts of complex sugar.

[0026] Furthermore, the invention also contains a composite plant extract, which is prepared from astragalus, atractylodes and red peony root in a mass ratio of 30-40:50-60:10-20; in parts by weight, the extract comprises 100-120 parts of acetaminophen, 1.8-2.2 parts of chlorpheniramine maleate, 9-11 parts of artificial bezoar, 45-55 parts of amantadine hydrochloride, 500-700 parts of sucrose, 100-150 parts of pulping sucrose, 14-18 parts of corn starch, 5-7 parts of strawberry essence, 150-250 parts of complex sugar and 10-20 parts of composite extract.

[0027] Furthermore, the preparation method of the composite extract includes the following steps: taking astragalus, atractylodes, and red peony root medicinal materials, adding purified water to extract twice, the solid-liquid ratio kg / L is 1:15-25, the first extraction temperature is 80-90°C, and the extraction time is 1.5-2.5h; the second extraction temperature is 95-100°C, and the extraction time is 0.8-1.2h; combining the extracts, filtering, and concentrating at 55-65°C to a thick paste with a relative density of 1.25-1.35 to obtain a composite plant extract.

[0028] The present invention also provides a production process of ammonia golden yellow sensitive granules, comprising the following steps: (1) adding slurry sucrose to purified water in a sandwich pot, boiling for 15-25 minutes, filtering with a 200-mesh screen, adding purified water to prepare a syrup adhesive with a concentration of 65-75%wt, cooling to below 40°C, and setting aside;

[0029] (2) artificial bezoar and chlorpheniramine maleate are mixed evenly, and corn starch, amantadine hydrochloride, acetaminophen and the composite extract are added respectively according to the principle of equal amounts, and each material is shaken through an 80-mesh sieve to mix evenly;

[0030] (3) crushing sucrose into sucrose powder, adding the mixed materials, sucrose powder and complex sugar into a wet granulator, turning on the stirring and cutting knife for 8-12 minutes to mix the raw materials and auxiliary materials evenly;

[0031] (4) Add the syrup binder into the wet granulator, mix at a low speed for 100-150 seconds, then turn on the cutter and cut at a high speed for 40-60 seconds to make a soft material;

[0032] (5) The soft material is poured into a swing granulator or a double-roll swing granulator and granulated by swinging through a 24-mesh sieve;

[0033] (6) The granules after swing granulation are placed in a high-efficiency fluidized bed dryer for drying at a temperature of 55-65° C. for 10-20 minutes. During the drying process, the bags are shaken once every 1.5-2.5 minutes. The granules are discharged when the temperature drops below 40° C.;

[0034] (7) The dried granules are sieved through a linear sieve with an upper layer of 20 mesh and a lower layer of 60 mesh. The coarse granules that cannot pass through are put into a swing granulator and sized using a 22-mesh sieve, and the sized granules are collected;

[0035] (8) After granulation, the qualified granules and strawberry essence are poured into a square cone mixer, the mixing speed is set to 30-50 Hz, the mixing time is set to 15-25 minutes, and the mixer is started for mixing.

[0036] Compared with the prior art, the present invention has the following beneficial effects:

[0037] (1) The ammonia golden yellow sensitive particles prepared by the specific process conditions of the present invention have a certain inhibitory effect on influenza A (H1N1) virus and a good anti-influenza effect. In addition, the ammonia golden yellow sensitive particles prepared by the present invention have good stability.

[0038] (2) The present invention adds a small amount of complex sugars composed of oligoxylose, L-arabinose, and yeast β-glucan in a certain proportion to enhance the efficacy of acetaminophen, chlorpheniramine maleate, artificial bezoar, and amantadine hydrochloride. The prepared ammonia golden yellow sensitive granules not only help to improve the inhibitory effect on influenza virus, but also significantly reduce the amount of sucrose added, improve the taste of the medicine, and also help to enhance immunity.

[0039] (3) The present invention adds a composite plant extract made from astragalus, atractylodes and red peony root, which can reduce the base amount of acetaminophen and play the roles of strengthening the spleen and replenishing qi, clearing the lungs and dispersing evil, soothing the liver and regulating qi, etc., and can further enhance the efficacy of the aminojinjinmin granules. Astragalus, atractylodes and red peony root are medicinal materials that are both medicinal and edible, which is beneficial to reducing the side effects of the drugs. DETAILED DESCRIPTION

[0040] In order to better understand the technical content of the present invention, specific embodiments are provided below to further illustrate the present invention.

[0041] Unless otherwise specified, the experimental methods used in the embodiments of the present invention are all conventional methods.

[0042] Unless otherwise specified, the materials, reagents, etc. used in the embodiments of the present invention can be obtained from commercial sources.

[0043] Example 1

[0044] Ammonia golden yellow sensitive granules include the following raw materials in parts by weight: 150 parts of acetaminophen, 2 parts of chlorpheniramine maleate, 10 parts of artificial bezoars, 50 parts of amantadine hydrochloride, 1638 parts of sucrose, 133.3 parts of pulped sucrose, 16.7 parts of corn starch, and 6.1 parts of strawberry flavor.

[0045] The production process of the above-mentioned ammonia golden yellow sensitive granules comprises the following steps:

[0046] (1) Adding slurry sucrose to purified water in a sandwich pot, boiling for 20 minutes, filtering with a 200-mesh screen, adding purified water to prepare a syrup adhesive with a concentration of 70%wt, cooling to below 40°C, and setting aside;

[0047] (2) artificial bezoar and chlorpheniramine maleate are mixed evenly, and corn starch, amantadine hydrochloride, and acetaminophen are added respectively according to the principle of equal amounts, and each material is shaken through an 80-mesh sieve to mix evenly;

[0048] (3) crushing sucrose into sucrose powder, adding the mixed materials and sucrose powder into a wet granulator, turning on the stirring and cutting knife for 10 minutes to mix the raw materials and auxiliary materials evenly;

[0049] (4) Add the syrup binder into the wet granulator, mix at low speed (25 rpm) for 120 seconds, then turn on the cutter and cut at high speed (250 rpm) for 50 seconds to make a soft material;

[0050] (5) The soft material is poured into a swing granulator or a double-roll swing granulator and granulated by swinging through a 24-mesh sieve;

[0051] (6) The granules after swing granulation are placed in a high-efficiency fluidized bed dryer for drying at 60° C. for 15 minutes. During the drying process, the bags are shaken once every 2 minutes. The granules are discharged when the temperature drops below 40° C.;

[0052] (7) The dried granules are sieved through a linear sieve with an upper layer of 20 mesh and a lower layer of 60 mesh. The coarse granules that cannot pass through are put into a swing granulator and sized using a 22-mesh sieve, and the sized granules are collected;

[0053] (8) After granulation, the qualified granules and strawberry essence are poured into a square cone mixer, the mixing speed is set to 40 Hz, the mixing time is set to 20 minutes, and the mixing is started.

[0054] Example 2

[0055] A kind of aminoacid golden yellow sensitive granules, comprising the following raw materials in parts by weight: 150 parts of acetaminophen, 2 parts of chlorpheniramine maleate, 10 parts of artificial bezoar, 50 parts of amantadine hydrochloride, 638 parts of sucrose, 133.3 parts of pulping sucrose, 16.7 parts of corn starch, 6.1 parts of strawberry flavor, and 200 parts of complex sugar, wherein the complex sugar is composed of oligoxylose, L-arabinose, and yeast β-glucan in a mass ratio of 20:30:50;

[0056] The production process of the above-mentioned ammonia golden yellow sensitive granules comprises the following steps:

[0057] (1) Adding slurry sucrose to purified water in a sandwich pot, boiling for 20 minutes, filtering with a 200-mesh screen, adding purified water to prepare a syrup adhesive with a concentration of 70%wt, cooling to below 40°C, and setting aside;

[0058] (2) artificial bezoar and chlorpheniramine maleate are mixed evenly, and corn starch, amantadine hydrochloride, and acetaminophen are added respectively according to the principle of equal amounts, and each material is shaken through an 80-mesh sieve to mix evenly;

[0059] (3) crushing sucrose into sucrose powder, adding the mixed materials, sucrose powder and complex sugar into a wet granulator, turning on the stirring and cutting knife for 10 minutes to mix the raw materials and auxiliary materials evenly;

[0060] (4) Add the syrup binder into the wet granulator, mix at low speed (25 rpm) for 120 seconds, then turn on the cutter and cut at high speed (250 rpm) for 50 seconds to make a soft material;

[0061] (5) The soft material is poured into a swing granulator or a double-roll swing granulator and granulated by swinging through a 24-mesh sieve;

[0062] (6) The granules after swing granulation are placed in a high-efficiency fluidized bed dryer for drying at 60° C. for 15 minutes. During the drying process, the bags are shaken once every 2 minutes. The granules are discharged when the temperature drops below 40° C.;

[0063] (7) The dried granules are sieved through a linear sieve with an upper layer of 20 mesh and a lower layer of 60 mesh. The coarse granules that cannot pass through are put into a swing granulator and sized using a 22-mesh sieve, and the sized granules are collected;

[0064] (8) After granulation, the qualified granules and strawberry essence are poured into a square cone mixer, the mixing speed is set to 40 Hz, the mixing time is set to 20 minutes, and the mixing is started.

[0065] Example 3

[0066] A kind of aminoacid golden yellow sensitive granules, comprising the following raw materials in parts by weight: 100 parts of acetaminophen, 2 parts of chlorpheniramine maleate, 10 parts of artificial bezoar, 50 parts of amantadine hydrochloride, 1638 parts of sucrose, 133.3 parts of pulping sucrose, 16.7 parts of corn starch, 6.1 parts of strawberry flavor, 200 parts of complex sugar, and 15 parts of complex extract;

[0067] The complex sugar is composed of oligoxylose, L-arabinose and yeast beta-glucan in a mass ratio of 20:30:50;

[0068] The composite plant extract is prepared from astragalus, atractylodes macrocephala and red peony root in a mass ratio of 35:55:15;

[0069] The preparation method of the composite extract comprises the following steps: taking astragalus, atractylodes and red peony root medicinal materials, adding purified water for extraction twice, the material-liquid ratio kg / L is 1:20, the first extraction temperature is 85°C, the extraction time is 2.0h; the second extraction temperature is 95°C, the extraction time is 1.0h; combining the extracts, filtering, and concentrating at 60°C to a thick paste with a relative density of 1.30 to obtain the composite plant extract;

[0070] The production process of the above-mentioned ammonia golden yellow sensitive granules comprises the following steps:

[0071] (1) Adding slurry sucrose to purified water in a sandwich pot, boiling for 20 minutes, filtering with a 200-mesh screen, adding purified water to prepare a syrup adhesive with a concentration of 70%wt, cooling to below 40°C, and setting aside;

[0072] (2) artificial bezoar and chlorpheniramine maleate are mixed evenly, and corn starch, amantadine hydrochloride, acetaminophen and the composite extract are added respectively according to the principle of equal amounts, and each material is shaken through an 80-mesh sieve to mix evenly;

[0073] (3) crushing sucrose into sucrose powder, adding the mixed materials, sucrose powder and complex sugar into a wet granulator, turning on the stirring and cutting knife for 10 minutes to mix the raw materials and auxiliary materials evenly;

[0074] (4) Add the syrup binder into the wet granulator, mix at low speed (25 rpm) for 120 seconds, then turn on the cutter and cut at high speed (250 rpm) for 50 seconds to make a soft material;

[0075] (5) The soft material is poured into a swing granulator or a double-roll swing granulator and granulated by swinging through a 24-mesh sieve;

[0076] (6) The granules after swing granulation are placed in a high-efficiency fluidized bed dryer for drying at 60° C. for 15 minutes. During the drying process, the bags are shaken once every 2 minutes. The granules are discharged when the temperature drops below 40° C.;

[0077] (7) The dried granules are sieved through a linear sieve with an upper layer of 20 mesh and a lower layer of 60 mesh. The coarse granules that cannot pass through are put into a swing granulator and sized using a 22-mesh sieve, and the sized granules are collected;

[0078] (8) After granulation, the qualified granules and strawberry essence are poured into a square cone mixer, the mixing speed is set to 40 Hz, the mixing time is set to 20 minutes, and the mixing is started.

[0079] Comparative Example 1

[0080] The difference from Example 1 is that the production process conditions are different:

[0081] The production process of the above-mentioned ammonia golden yellow sensitive granules comprises the following steps:

[0082] (1) Adding sucrose pulp to purified water in a sandwich pot, boiling for 20 minutes, filtering with a 200-mesh screen, adding purified water to prepare a syrup adhesive with a concentration of 80%wt, cooling to below 40°C, and setting aside;

[0083] (2) artificial bezoar and chlorpheniramine maleate are mixed evenly, and corn starch, amantadine hydrochloride, and acetaminophen are added respectively according to the principle of equal amounts, and each material is shaken through an 80-mesh sieve to mix evenly;

[0084] (3) crushing sucrose into sucrose powder, adding the mixed materials and sucrose powder into a wet granulator, turning on the stirring and cutting knife for 10 minutes to mix the raw materials and auxiliary materials evenly;

[0085] (4) Add the syrup binder into the wet granulator, mix at low speed (50 rpm) for 120 seconds, then turn on the cutter and cut at high speed (500 rpm) for 50 seconds to make a soft material;

[0086] (5) The soft material is poured into a swing granulator or a double-roll swing granulator and granulated by swinging through a 24-mesh sieve;

[0087] (6) The granules after swing granulation are placed in a high-efficiency fluidized bed dryer for drying at 70° C. for 15 minutes. During the drying process, the bags are shaken once every 2 minutes. The granules are discharged when the temperature drops below 40° C.;

[0088] (7) The dried granules are sieved through a linear sieve with an upper layer of 20 mesh and a lower layer of 60 mesh. The coarse granules that cannot pass through are put into a swing granulator and sized using a 22-mesh sieve, and the sized granules are collected;

[0089] (8) After granulation, the qualified granules and strawberry essence are poured into a square cone mixer, the mixing speed is set to 20 Hz, the mixing time is set to 40 minutes, and the mixing is started.

[0090] Comparative Example 2

[0091] The difference from Example 2 is that the complex sugar does not contain yeast β-glucan, and is composed of oligoxylose and L-arabinose in a mass ratio of 20:30. Other raw materials and auxiliary materials are the same as those in Example 2.

[0092] Comparative Example 3

[0093] The difference from Example 2 is that the complex sugar is composed of oligoxylose, L-arabinose and yeast β-glucan in a mass ratio of 1:1:1. Other raw materials and auxiliary materials are the same as those in Example 2.

[0094] Comparative Example 4

[0095] The difference from Example 3 is that the composite extract does not contain red peony root, and is prepared from astragalus and atractylodes in a mass ratio of 35:55. Other raw materials and auxiliary materials are the same as those in Example 3.

[0096] Comparative Example 5

[0097] The difference from Example 3 is that the composite extract is prepared from Astragalus, Atractylodes macrocephala and Paeonia lactiflora in a mass ratio of 3:2:1. Other raw materials and auxiliary materials are the same as those in Example 3.

[0098] 1. Efficacy Test

[0099] 180 BALB / c mice weighing 25±5g were selected, anesthetized with 3-bromoethanol, and infected with 20μL of 4LD50 H1N1 mouse lung adapted strain virus solution by nasal drops; the mice were randomly divided into groups, each with 20 mice, including test groups 1 to 8 and a control group, and the control group was given 15% ethanol + PBS buffer; administration began 3 hours after infection, and the test groups 1 to 8 were respectively given the aminoglycine granules of Examples 1 to 3 and Comparative Examples 1 to 5, with a dosage of 10mg / kg / d, and the administration method was: after the drug was mixed with PBS, it was immediately administered, administered by oral gavage, once a day, and continuously administered for 7d; after 20d of infection, the number of surviving mice was counted, and the percentage of mortality reduction was calculated. The results are shown in Table 1.

[0100] Mortality reduction percentage (%) = (number of mice killed in the control group - number of mice killed in the experimental group) / number of mice killed in the control group * 100%

[0101] Table 1 Inhibition of influenza virus

[0102]

[0103]

[0104] The results show that, compared with the control group, each example and comparative example has a certain inhibitory effect on the H1N1 virus. Among them, Example 3 has the best inhibitory effect on the H1N1 virus.

[0105] 2. Stability inspection

[0106] The stability of Examples 1-3 was investigated under the following conditions: sealed at 30°C ± 2°C, 65% ± 5%, and the investigation period was 6 months.

[0107] Table 2 Inspection criteria

[0108]

[0109] The results showed that the inspection / test results at 0 months, 1 month, 2 months, 3 months and 6 months all met the standard requirements, and there was no significant difference between the results at 1 month, 2 months, 3 months and 6 months and the results at 0 month, indicating good stability.

[0110] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A production process of ammonia golden yellow sensitive granules, characterized in that: The aminoacid gold-sensitive granules include the following raw materials in parts by weight: 100-160 parts of acetaminophen, 1.8-2.2 parts of chlorpheniramine maleate, 9-11 parts of artificial bezoar, 45-55 parts of amantadine hydrochloride, 500-1700 parts of sucrose, 100-150 parts of pulped sucrose, 14-18 parts of corn starch, and 5-7 parts of strawberry flavor; The production process of the ammonia golden yellow sensitive granules comprises the following steps: (1) adding slurry sucrose to purified water in a sandwich pot, boiling, filtering, adding purified water to prepare a syrup adhesive, cooling, and setting aside; (2) artificial bezoar and chlorpheniramine maleate are mixed evenly, and corn starch, amantadine hydrochloride, and acetaminophen are added respectively according to the principle of equal amounts, and each material is shaken and sieved to mix evenly; (3) crushing sucrose into sucrose powder, adding the mixed materials in step (2) and the sucrose powder into a wet granulator, turning on the stirring and cutting blades to mix the raw and auxiliary materials evenly; (4) adding the syrup binder from step (1) into a wet granulator, mixing at a low speed first, then turning on the cutter and cutting at a high speed to make a soft material; (5) Pour the soft material into a swing granulator or a double-roll swing granulator for granulation; (6) placing the granules after swing granulation in a high-efficiency fluidized bed dryer for drying, cooling, and discharging; (7) sieving and sizing the dried granules, and collecting the sizing granules; (8) Pour the whole granules and strawberry essence into a mixer and start mixing.

2. The production process of ammonia golden yellow sensitive granules according to claim 1, characterized in that: In step (1), the mass concentration of the syrup binder is 65-75%.

3. The production process of ammonia golden yellow sensitive granules according to claim 1, characterized in that: In step (4), the rotation speed of the low-speed mixing is 20-30 rpm, and the time of the low-speed mixing is 100-150 seconds; the rotation speed of the high-speed cutting is 200-300 rpm, and the time of the high-speed cutting is 40-60 seconds.

4. The production process of ammonia golden yellow sensitive granules according to claim 1, characterized in that: In step (6), the drying temperature is 55-65° C. and the drying time is 10-20 minutes. In step (8), the mixing speed is set to 30-50 Hz and the mixing time is set to 15-25 minutes.

5. The production process of ammonia golden yellow sensitive granules according to claim 1, characterized in that: The following steps are involved: (1) Adding slurry sucrose to purified water in a sandwich pot, boiling for 15-25 minutes, filtering with a 200-mesh screen, adding purified water to prepare a syrup adhesive with a concentration of 65-75%wt, cooling to below 40°C, and setting aside; (2) artificial bezoar and chlorpheniramine maleate are mixed evenly, and corn starch, amantadine hydrochloride, and acetaminophen are added respectively according to the principle of equal amounts, and each material is shaken through an 80-mesh sieve to mix evenly; (3) crushing sucrose into sucrose powder, adding the mixed materials and sucrose powder into a wet granulator, turning on the stirring and cutting knife for 8-12 minutes to mix the raw materials and auxiliary materials evenly; (4) Add the syrup binder into the wet granulator, mix at a low speed of 20-30 rpm for 100-150 seconds, then start the cutter, and cut at a high speed of 200-300 rpm for 40-60 seconds to make a soft material; (5) The soft material is poured into a swing granulator or a double-roll swing granulator and granulated by swinging through a 24-mesh sieve; (6) The granules after swing granulation are placed in a high-efficiency fluidized bed dryer for drying at a temperature of 55-65° C. for 10-20 minutes. During the drying process, the bags are shaken once every 1.5-2.5 minutes, and the granules are discharged when the temperature drops below 40° C.; (7) The dried granules are sieved through a linear sieve with an upper layer of 20 mesh and a lower layer of 60 mesh. The coarse granules that cannot pass through are put into a swing granulator and sized using a 22-mesh sieve, and the sized granules are collected; (8) After granulation, the qualified granules and strawberry essence are poured into a square cone mixer, the mixing speed is set to 30-50 Hz, the mixing time is set to 15-25 minutes, and the mixer is started for mixing.

6. The production process of ammonia golden yellow sensitive granules according to claim 1, characterized in that: The invention also contains complex sugar, which is composed of oligoxylose, L-arabinose and yeast beta-glucan in a mass ratio of 18-22:25-35:45-55; in parts by weight, the invention comprises 145-155 parts of acetaminophen, 1.8-2.2 parts of chlorpheniramine maleate, 9-11 parts of artificial bezoar, 45-55 parts of amantadine hydrochloride, 500-700 parts of sucrose, 100-150 parts of pulping sucrose, 14-18 parts of corn starch, 5-7 parts of strawberry essence and 150-250 parts of complex sugar.

7. The production process of ammonia golden yellow sensitive granules according to claim 1 or 6, characterized in that: The invention also contains a composite plant extract, which is prepared from astragalus, atractylodes macrocephala and red peony root in a mass ratio of 30-40:50-60:10-20; and contains, by weight, 100-120 parts of acetaminophen, 1.8-2.2 parts of chlorpheniramine maleate, 9-11 parts of artificial bezoars, 45-55 parts of amantadine hydrochloride, 500-700 parts of sucrose, 100-150 parts of pulping sucrose, 14-18 parts of corn starch, 5-7 parts of strawberry essence, 150-250 parts of complex sugar and 10-20 parts of the composite extract.

8. The production process of ammonia golden yellow sensitive granules according to claim 1, characterized in that: The preparation method of the composite extract comprises the following steps: taking astragalus, atractylodes and red peony root medicinal materials, adding purified water for extraction twice, the solid-liquid ratio kg / L is 1:15-25, the first extraction temperature is 80-90°C, and the extraction time is 1.5-2.5h; the second extraction temperature is 95-100°C, and the extraction time is 0.8-1.2h; combining the extracts, filtering, and concentrating at 55-65°C to a thick paste with a relative density of 1.25-1.35 to obtain the composite plant extract.

9. The production process of ammonia golden yellow sensitive granules according to claim 1, characterized in that: The following steps are involved: (1) Adding slurry sucrose to purified water in a sandwich pot, boiling for 15-25 minutes, filtering with a 200-mesh screen, adding purified water to prepare a syrup adhesive with a concentration of 65-75%wt, cooling to below 40°C, and setting aside; (2) artificial bezoar and chlorpheniramine maleate are mixed evenly, and corn starch, amantadine hydrochloride, acetaminophen and the composite extract are added respectively according to the principle of equal amounts, and each material is shaken through an 80-mesh sieve to mix evenly; (3) crushing sucrose into sucrose powder, adding the mixed materials, sucrose powder and complex sugar into a wet granulator, turning on the stirring and cutting knife for 8-12 minutes to mix the raw materials and auxiliary materials evenly; (4) Add the syrup binder into the wet granulator, mix at a low speed of 20-30 rpm for 100-150 seconds, then start the cutter, and cut at a high speed of 200-300 rpm for 40-60 seconds to make a soft material; (5) The soft material is poured into a swing granulator or a double-roll swing granulator and granulated by swinging through a 24-mesh sieve; (6) The granules after swing granulation are placed in a high-efficiency fluidized bed dryer for drying at a temperature of 55-65° C. for 10-20 minutes. During the drying process, the bags are shaken once every 1.5-2.5 minutes, and the granules are discharged when the temperature drops below 40° C.; (7) The dried granules are sieved through a linear sieve with an upper layer of 20 mesh and a lower layer of 60 mesh. The coarse granules that cannot pass through are put into a swing granulator and sized using a 22-mesh sieve, and the sized granules are collected; (8) After granulation, the qualified granules and strawberry essence are poured into a square cone mixer, the mixing speed is set to 30-50 Hz, the mixing time is set to 15-25 minutes, and the mixer is started for mixing.

10. Ammonia golden yellow sensitive granule, characterized in that: The invention is prepared by the production process described in claims 1 to 9.

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