Medicinal and edible traditional Chinese medicine ointment for treating infantile diarrhea and preparation method of medicinal and edible traditional Chinese medicine ointment

Abstract

The invention discloses a medicinal and edible traditional Chinese medicine ointment formula for treating infantile diarrhea and a preparation method thereof. The traditional Chinese medicine ointment formula is prepared from the following raw materials in parts by weight: 5-7 parts of poria cocos, 5-7 parts of semen euryales and 5-7 parts of semen coicis. According to the traditional Chinese medicine ointment formula for treating infantile spleen and stomach weakness type diarrhea, the poria cocos which can promote diuresis, excrete dampness, invigorate the spleen and calm the heart is used as the monarch drug, the semen euryales which can tonify the kidney, secure essence, tonify the spleen, stop diarrhea, eliminate dampness and stop leucorrhea is used as the ministerial drug, and the semen coicis which can promote diuresis, excrete dampness, invigorate the spleen, stop diarrhea, eliminate arthralgia, expel pus, detoxify and dissipate stagnation is used as the adjuvant drug, so that the effects of invigorating the spleen, excrete dampness, stop diarrhea and induce astringency Therefore, the improvement degree of clinical symptoms of the infantile spleen-stomach deficiency type diarrhea is effectively improved.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a Chinese medicine paste prescription with both medicinal and edible properties for treating diarrhea in children and a preparation method thereof. Background Art

[0002] Diarrhea is the second leading cause of death in children under five worldwide, with more than 500,000 children dying from diarrheal diseases each year. The situation is even more serious in developing countries. Diarrhea in children may also cause dehydration, electrolyte imbalance, malnutrition, and even irreversible damage such as convulsions and brain damage. Long-term and repeated diarrhea will affect children's absorption of nutrients, leading to problems such as weight loss and height stunting, hindering their normal growth and development, and will also have a long-term negative impact on the development of their physical and cognitive functions.

[0003] Spleen and stomach deficiency type diarrhea is more common in children and is a manifestation of spleen and stomach dysfunction. Traditional Chinese medicine believes that it is related to congenital spleen and stomach deficiency and acquired malnutrition. The core pathogenesis of children's spleen and stomach deficiency type diarrhea is the dysfunction of the spleen and stomach, and the inability to digest food and water. When the spleen and stomach are weak, their ability to transport food and water is weakened, food cannot be fully digested and absorbed, stagnates in the intestines, mixes with water, forms loose stools and is excreted from the body. Weak spleen and stomach, insufficient middle qi, and dysfunctional intestinal conduction can also lead to increased bowel movements and soft stools. Therefore, traditional Chinese medicine aims to achieve the purpose of stopping diarrhea by strengthening the spleen and stomach function and restoring its ability to transport food and water, while promoting the growth and development of children's bodies and their healthy recovery. Summary of the invention

[0004] The object of the present invention is to design a Chinese medicine paste prescription for treating diarrhea in children and a preparation method thereof. By selecting raw materials of the same origin as medicine and food, the prepared Chinese medicine paste prescription has the characteristics of being green and safe, and the dosage form of the paste prescription makes the effective ingredients of the medicine more easily absorbed by children, and the taste is relatively good and easy for children to accept. By taking this paste prescription for a long time, the spleen and stomach function of children can be gradually enhanced, the condition of spleen and stomach weakness can be improved, thereby effectively alleviating diarrhea symptoms and promoting the healthy growth of children.

[0005] In order to achieve the above object, the technical solution adopted by the present invention is as follows:

[0006] A Chinese medicinal paste prescription for treating diarrhea in children, characterized in that the Chinese medicinal paste prescription is composed of the following raw materials in parts by weight: 5 to 7 parts of Poria cocos, 5 to 7 parts of Euryale ferox, and 5 to 7 parts of Coix seeds.

[0007] The pharmacological effects of each Chinese medicine component in the present invention are as follows:

[0008] Poria cocos is the dried sclerotium of the Polyporaceae fungus Poria cocos. It tastes sweet and light, is neutral in nature, and enters the heart, lung, spleen, and kidney meridians. It has the effects of promoting water and dampness, strengthening the spleen, and calming the mind. Poria cocos can enhance the function of the spleen and stomach and help the spleen and stomach to transport and transform water and dampness. It can restore the disordered metabolism of water and dampness to normal, and enhance the spleen and stomach's ability to transport and transform water and grain by strengthening the spleen. Modern research shows that Poria cocos can regulate the intestinal flora, affect the intestinal absorption and secretion function, and thus achieve the purpose of stopping diarrhea.

[0009] Gorgon fruit is the dried mature seed kernel of Gorgon gorgonii, a plant of the Nymphaeaceae family. It tastes sweet and astringent, is neutral in nature, and enters the spleen and kidney meridians. It has the effects of benefiting the kidney and consolidating essence, tonifying the spleen and stopping diarrhea, and removing dampness and stopping leukorrhea. Gorgon fruit can nourish the spleen and stomach, strengthen the transportation and transformation function of the spleen and stomach, and has a good therapeutic effect on diarrhea caused by weak spleen and stomach. At the same time, the astringent nature of Gorgon fruit can reduce loose stools, and prevent the stool from slipping by consolidating the intestines. Modern research shows that Gorgon fruit helps to restore the stability of intestinal function, regulate the digestion and absorption function of the intestines, and has a certain anti-inflammatory effect, thereby relieving diarrhea symptoms.

[0010] Coix seed is the dried mature seed of the Gramineae plant Coix. It tastes sweet and light, is cool in nature, and enters the spleen, stomach, and lung meridians. It has the effects of promoting water and eliminating dampness, strengthening the spleen and stopping diarrhea, removing numbness, draining pus, and detoxifying and dispersing knots. Coix seed has the effect of strengthening the spleen and eliminating dampness. By enhancing the transportation and transformation power of the spleen and stomach, it can make the metabolites such as water and dampness be discharged normally, and avoid the accumulation of dampness in the spleen and stomach and cause diarrhea. Modern research shows that the ingredients such as coix ester and coix seed oil contained in coix seed can regulate the function of intestinal mucosa, repair and protect the intestinal mucosa. It can also regulate the motor function of the intestine to play a role in diarrhea.

[0011] A method for preparing the Chinese medicinal ointment prescription for treating diarrhea in children as claimed in claim 1, characterized in that the method is as follows:

[0012] S1: Preparation of clear paste: taking Poria cocos, Euryale ferox and Coix seeds according to weight proportions, extracting and filtering, and concentrating the filtrate to obtain a clear paste;

[0013] S2: Syrup treatment: Heat the sucrose until it is completely dissolved, turn to low heat after boiling, and stir continuously until most of the water in the syrup evaporates. When large bubbles appear, add cold water and continue to heat until boiling, then pour out while hot, filter to remove impurities, and the sucrose syrup is obtained;

[0014] S3: Preparation of paste formula: Add the syrup from step S2 to the clear paste from step S1, simmer over low heat and stir continuously until the liquid medicine is concentrated to the point where it forms "fish-eye bubbles" and can be pulled into flags or dropped into water to form beads.

[0015] Furthermore, in S1, the filtrate is concentrated to a relative density of 1.1 to 1.2.

[0016] Furthermore, in S1, the extraction is performed 3 times in total, 10 times the volume of water is added each time, and each extraction lasts 100 minutes.

[0017] Furthermore, in S2, 10% to 20% volume of cold water is added to the syrup.

[0018] Furthermore, in S2, impurities are removed by filtering with an 80-mesh sieve.

[0019] Furthermore, in S3, the mass ratio of the clear paste to the syrup is 1:2.

[0020] The following beneficial effects can be obtained through the above technical solution:

[0021] The Chinese medicine paste prescription for treating diarrhea of ​​spleen and stomach deficiency type provided by the present invention takes the effects of Poria cocos in promoting diuresis and eliminating dampness, invigorating the spleen and calming the mind as the main ingredient, Euryale ferox invigorating the kidney and consolidating essence, tonifying the spleen and stopping diarrhea, removing dampness and stopping leukorrhea as the secondary ingredient, and Coix lachryma-jobi invigorating dampness and eliminating dampness, invigorating the spleen and stopping diarrhea, removing numbness, discharging pus, and detoxifying and dispersing knots as the adjuvant. All the medicines are used together to fully exert the effects of invigorating the spleen and eliminating dampness, stopping diarrhea and consolidating astringency, thereby effectively improving the improvement degree of clinical symptoms of diarrhea of ​​spleen and stomach deficiency type in children. At the same time, the Chinese medicine paste prescription of the present invention has suitable taste, is easy for children to accept, is convenient to take, has good patient compliance, has no drug toxicity and side effects, is beneficial to promoting the recovery of spleen and stomach function in children, and provides a medicine that is convenient to take, has definite efficacy, is safe and reliable, and is suitable for use by children for the clinical treatment of diarrhea of ​​spleen and stomach deficiency type in children, and has high application value and promotion prospects.

[0022] In general, the present invention has the following advantages:

[0023] (1) Innovative TCM legislation: In the treatment of diarrhea caused by spleen and stomach deficiency in children, the present invention proposes the concept of "strengthening the spleen and stopping diarrhea, strengthening the foundation and nourishing the essence" based on the principle that the spleen and stomach function is not complete and the transportation and transformation disorder causes diarrhea in children, and treats diarrhea caused by spleen and stomach deficiency in children and its related symptoms from the two aspects of "strengthening the spleen and eliminating dampness, and consolidating and stopping diarrhea". Therefore, the Chinese medicine composition of the present invention can not only effectively improve the diarrhea condition of children, but also promote the recovery and improvement of the overall digestion and absorption function of children by regulating the spleen and stomach function.

[0024] (2) The Chinese medicine composition of the present invention is relatively safe: Poria cocos, Euryale ferox and Coix seed are all Chinese medicines that can be used as both medicine and food. They are safe and have no toxic side effects. They are suitable for conditioning and treating the delicate constitution of children and have no adverse effects on the growth and development of children.

[0025] (3) Innovation in dosage form: The present invention adopts a paste dosage form, which has the advantages of good taste, easy control of dosage, good absorption, no need for complicated decoction, convenient administration and high compliance, and easy storage, which is convenient for children to take and parents to operate.

[0026] (4) Diversification of evaluation indicators: The present invention selects multiple evaluation indicators during the preparation process optimization process, which can more comprehensively evaluate the extraction process, ensure the effectiveness and stability of the drug, and comprehensively consider multiple aspects such as drug quality and production efficiency, which is conducive to optimizing the best extraction process. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 UV scanning spectra of reference and test samples;

[0028] Figure 2 is the standard curve of D-anhydrous glucose reference substance;

[0029] Figure 3 The HPLC chromatogram of the extract of the Chinese medicine paste prescription (the peak 1 in the figure represents pachymic acid; A is the reference sample chromatogram; B is the test sample chromatogram; C is the blank control chromatogram);

[0030] Figure 4 This is the standard curve of Pachycolic acid reference substance. DETAILED DESCRIPTION

[0031] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0032] Example 1: A Chinese medicinal ointment formula that is both medicinal and edible

[0033] The Chinese medicine paste recipe includes the following raw materials in parts by weight: 5-7 parts of Poria cocos, 5-7 parts of Euryale ferox, and 5-7 parts of Coix seeds. Subsequent examples or experimental examples are further studied with a Chinese medicine prescription of 6 parts of Poria cocos, 6 parts of Euryale ferox, and 6 parts of Coix seeds.

[0034] The preparation method of the Chinese medicine paste prescription comprises the following steps:

[0035] (1) Preparation of clear paste: Take slices of Poria cocos, Euryale ferox and Coix seed according to the prescription ratio, extract for 100 min, extract 3 times, add 10 times the amount of water each time, combine the filtrates, filter, and concentrate the filtrate to a relative density of 1.1-1.2 to obtain a clear paste.

[0036] (2) Processing method of syrup: Place sucrose in a pot and heat it until it is completely dissolved. After boiling, turn to low heat and stir continuously. When boiling, use a mesh sieve or silk sieve to remove the floating foam on the surface. Wait until most of the water in the syrup evaporates and large bubbles appear. Add about 10% of the volume of cold water and continue to heat until it boils. Then pour out while it is hot and filter with an 80-mesh sieve to remove impurities. This will make syrup.

[0037] (3) Preparation of paste formula: Take the syrup from step (2) and add it to the clear paste at a mass ratio of 1:2. Slowly simmer over low heat and stir continuously with a spatula until the liquid medicine is concentrated to the point where it forms "fish-eye bubbles" and can be pulled into flags or dropped into water to form beads (drop the paste into clear water to condense into beads without dispersing).

[0038] Example 2: Optimization of the best preparation process of a Chinese medicine paste recipe with both medicinal and edible properties

[0039] The determination of total polysaccharide content can reflect the efficacy of the drug to a certain extent. Pachycolic acid is the effective component of the main drug Poria cocos in the prescription, and the dry paste rate can directly reflect the dissolution of other components. Therefore, the total polysaccharide content, Pachycolic acid content and dry paste rate were selected as the evaluation indicators of the optimal preparation process of the Lingyi Chinese medicine paste prescription for children.

[0040] The specific test includes the following steps:

[0041] (1) Establishment of a method for determining the total polysaccharide content in traditional Chinese medicine ointments:

[0042] 1.1 Preparation of reference solution

[0043] Take about 5.55 mg of D-anhydrous glucose reference substance, accurately weigh it, put it in a 50 mL volumetric flask, add pure water to dissolve and dilute to the scale, shake well, and you will get the D-anhydrous glucose reference substance solution (111 μg / mL).

[0044] 1.2 Preparation of test solution

[0045] Weigh the medicinal materials according to the prescription, add 10 times of water, decoct for 100 minutes, extract 3 times, filter through 8 layers of gauze and concentrate under reduced pressure (60°C) to about 200 mL, add ultrapure water to make up to 250 mL. Accurately measure 1 mL of the concentrate, place it in a 250 mL volumetric flask, add pure water to make up to the scale, shake well and filter through a 0.45 μm filter membrane to obtain the test solution.

[0046] 1.3 Selection of detection wavelength

[0047] Accurately pipette 1 mL of the reference solution under "1.1" and the test solution under "1.2" into two 10 mL colorimetric tubes of the same specifications, add 1 mL of pure water, and then add 8 mL of anthrone solution for color development, heat in a boiling water bath for 15 minutes, leave at room temperature, and ice bath for 10 minutes for color development. Use the blank solution as the blank and perform a full scan in the wavelength range of 400-900 nm. The results showed that the maximum absorption of the D-anhydrous glucose reference solution was at 627 nm, and the maximum absorption of the test solution was at 628 nm, so the ultraviolet maximum absorption wavelength was selected as 627 nm. The ultraviolet scanning spectra of the reference and test samples are shown in Figure 3 .

[0048] 1.4 Investigation of linear relationship

[0049] Accurately pipette 0, 0.5, 0.8, 1.0, 1.2, and 1.5 mL of the reference solution into different 10 mL colorimetric tubes, and measure the absorbance of different linear solutions according to the method in "1.3". Use the absorbance (Abs) as the ordinate and the solution concentration (μg / mL) as the abscissa to draw a linear graph, such as Figure 4 The linear equation was y=0.0414x+0.0865 (r=0.9991), indicating that the D-anhydrous glucose reference solution had a good linear relationship in the range of 0 to 16.65 μg / mL.

[0050] 1.5 Precision test

[0051] The same reference solution was sampled and measured 6 times in succession, the absorbance was recorded and the RSD was calculated. The results showed that the RSD of total polysaccharide content was 0.078%, indicating that the method had good precision.

[0052] 1.6 Repeatability test

[0053] Prepare 6 test solutions according to the preparation method of the test solution in step 3.2, place them in 10mL stoppered colorimetric tubes, record the absorbance and calculate the RSD. The results showed that the RSD of the total polysaccharide content was 0.244%, indicating that the method had good repeatability.

[0054] 1.7 Stability study

[0055] Accurately pipette 1 mL of the reference solution, and measure it after standing at room temperature for 0, 30, 60, 90, 120, and 150 minutes, record the absorbance, and calculate the RSD. The results show that the RSD is 0.09%, indicating that the method has good stability within 150 minutes after color development at room temperature.

[0056] 1.8 Sample recovery test

[0057] Accurately measure 0.5mL of the test solution with known content, add 0.5mL of the reference solution to make a 100% spiked test solution, repeat 6 times, continuously inject and analyze, calculate the recovery rate and average recovery rate. The results show that the average value of the total polysaccharide recovery rate is 103%, and the RSD is 1.53%, indicating that this method is feasible.

[0058] (2) Establish a method for determining the content of pachymic acid in Poria cocos, the main ingredient of traditional Chinese medicine ointment:

[0059] 2.1 Chromatographic conditions: Shimadzu high performance liquid chromatograph LC-20ADxr. Chromatographic column: Waters C18 5μm (4.6×250mm). Mobile phase: acetonitrile: phosphoric acid water (75:25). Flow rate: 0.6mL / min, column temperature: 30℃, detection wavelength: 210nm.

[0060] 2.2 Preparation of reference solution: Accurately weigh 2.06 mg of Pachycolic acid reference substance and place it in a 10 mL volumetric flask. Add methanol to dilute to the mark. Accurately transfer 1 mL and place it in a 5 mL volumetric flask. Dilute to the mark with methanol to obtain the reference solution (41.2 μg / mL).

[0061] 2.3 Preparation of test solution: Accurately measure 2.5 mL of sample, place in a 10 mL volumetric flask, add methanol to dilute to the scale, shake well, and filter through a 0.45 μm microporous membrane to obtain the test solution.

[0062] 2.4 Investigation of linear relationship: Accurately measure 50%, 80%, 100%, 120%, and 150% of the reference solution in step 2.2 and place them in injection vials. Then inject 0.6 μL of the solution according to the chromatographic conditions described in step 1.1 and draw a standard curve with the reference concentration as the horizontal axis (X) and the peak area as the vertical axis (Y). Figure 2 The standard curve of pachymic acid was y=5912.6x-4061.5 (r=0.9995), and the linear range was 20-61.8 μg / mL.

[0063] 2.5 Stability test: Take the same test solution and inject it at 0, 4, 8, 12, 16 and 24 hours respectively, record the peak area and calculate the RSD. The results show that the RSD of the pachymic acid peak area is 2.32%, and the sample solution is stable within 24 hours.

[0064] 2.6 Precision test: Take the same reference solution, inject it 6 times continuously, record the peak area and calculate the RSD. The results show that the RSD of the peak area of ​​pachymic acid is 0.18%, indicating that the precision of this method is good.

[0065] 2.7 Repeatability test: Prepare 6 test solutions according to the preparation method of the test solution in step 2.3, inject and measure them respectively, record the peak area and calculate the content of pachymic acid and RSD. The results show that the RSD of pachymic acid is 1.87%, indicating that the method has good repeatability.

[0066] 2.8 Sample recovery test: Accurately measure 0.5mL of the test solution with known content, add 0.5mL of the reference solution to make a 100% spiked test solution, parallel 6 times, continuously inject and analyze, calculate the recovery rate and average recovery rate. The results show that the average value of the recovery rate of pachymic acid is 102%, and the RSD is 2.33%. This shows that the method is feasible.

[0067] (3) Establish a method for determining the dry paste rate of traditional Chinese medicine ointment formulas: accurately measure 10 mL of sample and place it in an evaporating dish of known mass (W1). First, evaporate it in a water bath and then dry it at 105°C for 3 h. Weigh the total mass (W2) and calculate the dry paste rate according to the following formula (V is the fixed volume).

[0068]

[0069] (4) Orthogonal test

[0070] In this experiment, three levels of material-liquid ratio, extraction time and extraction times were selected for orthogonal experiment. The factor level design is shown in Table 1. According to the prescription ratio, 9 portions of Poria cocos, Euryale ferox and Coix seed were weighed and the mixture was added according to L9(3 3 ) were extracted according to the conditions of the orthogonal table, filtered, the filtrate was concentrated and fixed to 250 mL, and the total polysaccharide content, pachymic acid content and dry extract rate were determined.

[0071] Table 1. Table of factors and levels of orthogonal test for extraction process

[0072] level A B C 1 10 80 1 2 12 100 2 3 14 120 3

[0073] Table 2 Intuitive analysis table of orthogonal experiment of water extraction process

[0074]

[0075]

[0076] Table 3 Analysis of variance of total polysaccharide content

[0077] source SS f Mean Square F-number P-value A 370.07 2 185.03 1.36 P>0.05 B 598.02 2 299.01 2.19 P>0.05 C 5714.81 2 2857.41 20.96 P<0.05 D 272.61 2 136.31 1.00 P>0.05

[0078] Table 4 Analysis of variance of pachymic acid content

[0079] A SS f Mean Square F-number P-value B 121.05 2 60.52 0.46 P>0.05 C 1160.44 2 580.22 4.38 P>0.05 D 6223.77 2 3111.88 23.49 P<0.05 A 264.94 2 132.47 1.00 P>0.05

[0080] Table 5 Analysis of variance table of dry paste rate

[0081] source SS f Mean Square F-number P-value A 0.24 2 0.12 0.16 P>0.05 B 7.63 2 3.81 5.04 P>0.05 C 30.87 2 15.44 20.41 P<0.05 D 1.51 2 0.76 1.00 P>0.05

[0082] As shown in Table 2, the intuitive analysis table of total polysaccharide, the intuitive analysis table of pachymic acid content and the intuitive analysis table of dry paste rate show that the influence of the extraction process of Xiaoer Lingyi Gao is C>B>D>A. As shown in Tables 3, 4 and 5, the variance analysis table shows that factors A and B have no significant effect on the total polysaccharide content, pachymic acid content and dry paste rate, and factor C has a significant effect on the total polysaccharide content, pachymic acid content and dry paste rate. Combining the above optimal extraction conditions, and considering the extraction amount of effective ingredients and energy saving in production, the optimal extraction process of Xiaoer Lingyi Gao is finally determined to be A1B2C3, that is, the solid-liquid ratio is 10 times the water volume, the extraction time is 100min, and the number of extractions is 3 times.

[0083] Optimal preparation process verification test and results:

[0084] According to the prescription ratio, 3 portions of Poria cocos, Euryale ferox, and Coix seed slices were weighed, extracted and filtered according to the preferred process conditions, the filtrate was concentrated and fixed to 250 mL, and the total polysaccharide content, pachymic acid content, and dry cream rate were determined according to the above method. The results are shown in Table 6. The results showed that the average total polysaccharide content of three parallel verifications was 94.23 mg / g, the average pachymic acid content was 84.12 μg / mL, and the average dry cream rate was 9.17%, which was not much different from the maximum value of the orthogonal test comprehensive score, indicating that the screened preparation process conditions were basically stable.

[0085] Table 6 Optimal preparation process verification results

[0086] Serial number Total polysaccharide content mg / g Pachymic acid content μg / mL Dry paste rate % 1 93.47 87.12 8.38 2 94.98 80.90 9.70 3 94.23 84.35 9.43 average value 94.23 84.12 9.17

[0087] In short, the present invention provides a Chinese medicine paste for treating diarrhea in children. Poria strengthens the spleen and eliminates dampness, regulates intestinal function, Euryale ferox invigorates the kidney and consolidates essence, tonifies the spleen and stops diarrhea, and Coix seed promotes water and eliminates dampness, strengthens the spleen and stops diarrhea. These three medicines are compatible with each other, Poria and Coix seed focus on removing dampness, and Euryale ferox is biased towards astringent and stops diarrhea, and they play the role of strengthening the spleen and eliminating dampness, astringent intestines and stop diarrhea together, and are suitable for diarrhea caused by spleen deficiency and dampness, and have a good effect for treating diarrhea caused by spleen and stomach deficiency in children. At the same time, the Chinese medicine paste of the present invention is convenient to take, has good patient compliance, and has no drug toxicity and side effects, is conducive to overall conditioning of children's spleen and stomach function, in addition to stopping diarrhea, it can also improve the spleen and stomach damaged by diarrhea in children, enhance digestion and absorption capacity, improve children's physical fitness and resistance, and reduce the recurrence probability of diarrhea. Provide a convenient to take, reliable efficacy, no toxic side effects, suitable for long-term use of medicine for the clinical treatment of diarrhea caused by spleen and stomach deficiency, with high practical value.

[0088] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A Chinese medicinal ointment for treating diarrhea in children, characterized by: The Chinese medicine paste recipe is composed of the following raw materials in parts by weight: 5-7 parts of Poria cocos, 5-7 parts of Euryale ferox, and 5-7 parts of Coix seeds.

2. A method for preparing the Chinese medicinal ointment prescription for treating diarrhea in children according to claim 1, characterized in that: The method is as follows: S1: Preparation of clear paste: taking Poria cocos, Euryale ferox and Coix seeds according to weight proportions, extracting and filtering, and concentrating the filtrate to obtain a clear paste; S2: Syrup treatment: Heat the sucrose until it is completely dissolved, turn to low heat after boiling, and stir continuously until most of the water in the syrup evaporates. When large bubbles appear, add cold water and continue to heat until boiling, then pour out while hot, filter to remove impurities, and the sucrose syrup is obtained; S3: Preparation of paste prescription: Add the syrup from step S2 to the clear paste from step S1, simmer over low heat and stir continuously until the liquid medicine is concentrated to the point where it forms "fish-eye bubbles" and can be pulled into flags or dropped into water to form beads.

3. The method for preparing a Chinese medicinal ointment for treating diarrhea in children according to claim 2, characterized in that: In S1, the filtrate is concentrated to a relative density of 1.1 to 1.

2.

4. The method for preparing a Chinese medicinal ointment for treating diarrhea in children according to claim 2, characterized in that: In S1, the extraction was performed 3 times in total, 10 times the volume of water was added each time, and each extraction lasted 100 min.

5. The method for preparing a Chinese medicinal ointment for treating diarrhea in children according to claim 2, characterized in that: In the S2, 10% to 20% volume of cold water of the syrup is added.

6. The method for preparing a Chinese medicinal ointment for treating diarrhea in children according to claim 2, characterized in that: In the S2, impurities are removed by filtering with an 80-mesh sieve.

7. The method for preparing a Chinese medicinal ointment for treating diarrhea in children according to claim 2, characterized in that: In S3, the mass ratio of the clear paste to the syrup is 1:2.

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