Podophyllotoxin separation and purification device

Abstract

The invention relates to the technical field of podophyllotoxin extraction, in particular to a podophyllotoxin separation and purification device which comprises a juicing mechanism, and the juicing mechanism is used for squeezing juice in cut rhizomes and floral leaves. According to the device, a root pressing circular plate can rotate in a positioning ring when descending, so that an arc-shaped cutter at the bottom of the root pressing circular plate can perform two-section cutting when squeezing plant rhizomes, the uncut rhizomes can be cut again, and the juicing and extracting effect of the plant rhizomes can be improved; by means of the operation, medicinal juice can be synchronously subjected to filter-pressing extraction on the podophyllotoxin leaves and rhizomes of podophyllum plants, podophyllotoxin can be separated from the obtained liquid medicine through a decoction method, and due to the fact that the liquid medicine obtained through filter-pressing contains few impurities, medicinal substances obtained after decoction are convenient to filter, the podophyllotoxin separation speed is increased, and the podophyllotoxin separation efficiency is improved. Medicinal substances in floral leaves and rhizomes of plants can be synchronously extracted through the juicing mechanism, so that the waste of effective medicinal resources is avoided.

Description

Technical Field

[0001] The invention relates to the technical field of podophyllotoxin extraction, in particular to a podophyllotoxin separation and purification device. Background Art

[0002] Podophyllotoxin is a lignin anti-tumor ingredient extracted from the roots and stems of Podophyllum plants. It is a white crystalline powder, odorless and hygroscopic. Podophyllotoxin extracted from Podophyllum sinensis can be made into ointments and tinctures. Podophyllotoxin can effectively inhibit herpes viruses and inhibit mitosis in the middle stage of cells, and is used for toxic diseases. Podophyllotoxin can inhibit the division and proliferation of epithelial cells caused by human papillomavirus infection, causing necrosis and shedding of infected epithelial cells, thereby achieving the effect of treating genital warts.

[0003] At present, the separation and purification of podophyllotoxin mostly uses plant materials containing podophyllotoxin, such as the rhizomes of Podophyllum indica and Polygonum multiflorum. These plant rhizomes are crushed and extracted with organic solvents such as methanol and ethanol. Such solvents can dissolve podophyllotoxin and separate it from the plant materials. The main method is to grind the plant roots into powder and then dissolve them with the solvent. However, the juice in the flowers and leaves of plant medicinal materials also contains podophyllotoxin. The current separation and purification equipment is difficult to extract medicinal substances from the rhizomes and flowers and leaves of Podophyllum plants at the same time, thus resulting in a waste of effective medicinal resources. The crushing and drying degree of the rhizomes of plant medicinal materials will affect the solubility of the materials and solvents. When the water content in the powder is too high, it is easy to cause solvent dilution, which reduces the extraction rate of medicinal substances in the plant medicinal materials. Summary of the invention

[0004] The object of the present invention is to provide a podophyllotoxin separation and purification device to solve the problems raised in the above background technology.

[0005] To achieve the above object, the present invention provides the following technical solutions: A podophyllotoxin separation and purification device, comprising: A chopping centrifugal mechanism, wherein the chopping centrifugal mechanism is used to chop the rhizomes and flowers and leaves of the Podophyllum plant; A juice pressing mechanism, which is used for pressing juice from chopped rhizomes and flower leaves, and comprises a fixed ring plate, a mounting frame is fixedly connected to the top of the fixed ring plate, a reciprocating spiral groove is provided on the inner wall of the fixed ring plate, an embedded slider is slidably embedded in the reciprocating spiral groove, an L-shaped rod is fixedly connected to the end of the embedded slider, a juice pressing ring plate is fixedly connected to the bottom end of the L-shaped rod, a limited position cavity is provided inside the juice pressing ring plate, a limited position ring is rotatably sleeved in the limited position cavity, a sliding rod is fixedly connected to the inner wall of the limiting ring, a positioning ring is fixedly connected to the end of the sliding rod, a root pressing circular plate is rotatably sleeved in the positioning ring, and a plurality of arc-shaped cutters are fixedly connected to the bottom of the root pressing circular plate in an annular manner at equal distances; The powder drying mechanism is used to crush plant rhizomes into powder and perform cyclic drying treatment on the powder.

[0006] Furthermore, the shredding centrifugal mechanism includes a tank body fixedly connected to the mounting frame, a rotating tank is rotatably sleeved at the inner center position of the tank body, a filter press plate is screwed and sleeved at the bottom end of the rotating tank, a drainage pipe connected to the interior of the tank body is fixedly connected to the bottom of the tank body, a support frame is fixedly provided on the outside of the tank body, a gear ring is fixedly sleeved on the outer wall of the rotating tank, a spur gear is meshedly connected to one side of the gear ring, an output end of a driving motor is fixedly connected at the center position of the spur gear, and the driving motor is fixedly connected to the inner wall of the tank body.

[0007] Furthermore, a plurality of centrifugal shells are fixedly connected in an annular manner at equal distances inside the rotating tank, and a centrifugal filter plate is fixedly connected to each of the plurality of centrifugal shells.

[0008] Furthermore, a plurality of leaf cutting blades are fixedly connected at equal distances on the inner walls of the plurality of centrifugal shells, a fixed cylinder is sleeved at the center position of the rotating tank, the top of the fixed cylinder is fixedly connected to the bottom of the mounting frame, a plurality of fixed cutting blades are fixedly connected at equal distances in an annular manner on the outer wall of the fixed cylinder, and a plurality of sweeping blades are fixedly connected at equal distances in an annular manner on the bottom end of the fixed cylinder.

[0009] Furthermore, a rotating shaft is provided at the center position of the fixed cylinder, a plurality of root cutting blades are fixedly connected in an annular manner at equal distances on the outer wall of the rotating shaft, a plurality of fixed cutting blades 2 are fixedly connected in an annular manner at equal distances on the inner wall of the fixed cylinder, the top end of the rotating shaft is fixedly connected to the output end of a servo motor 1, the bottom end of the rotating shaft is fixedly connected to a linkage shaft, and the root pressing circular plate is slidably sleeved with the linkage shaft.

[0010] Furthermore, two limiting grooves are symmetrically provided on the inner wall of the rotating tank, and the juice pressing ring plate is slidably engaged with the limiting grooves.

[0011] Furthermore, the bottom of the fixed cylinder is fixedly connected to a flaring cylinder connected to the interior thereof, the rooting circular plate is slidably sleeved in the flaring cylinder, a vertical groove is provided on the flaring cylinder, the sliding rod is slidably connected to the vertical groove, and a plurality of filter holes are equidistantly provided in an annular shape on the outer wall of the flaring cylinder.

[0012] Furthermore, a frustum is fixedly sleeved on the outer wall of the expanding tube.

[0013] Furthermore, the powder drying mechanism includes a connecting cylinder fixedly connected to the bottom end of the expanding cylinder, the bottom end of the connecting cylinder is fixedly connected to a crushing cylinder, the end of the crushing cylinder is fixedly connected to a servo motor 2, the output end of the servo motor 2 is fixedly connected to a crushing knife shaft, the side wall of the crushing cylinder is fixedly connected to the output end of a hot air blower, the end of the crushing cylinder is fixedly connected to a circulation pipe connected to the interior thereof, the circulation pipe is fixedly connected to a powder outlet pipe, the powder outlet pipe is fixedly provided with an electromagnetic valve 1, and the circulation pipe is fixedly provided with an electromagnetic valve 2.

[0014] Furthermore, a sealing round block is arranged at the top of the connecting tube, and two extrusion springs fixedly connected to the inner wall of the connecting tube are symmetrically fixedly connected to the bottom of the sealing round block.

[0015] Compared with the prior art, the present invention has the following beneficial effects: 1. The rhizome of Podophyllum sphaerocephalum is put into a fixed cylinder, and its flowers and leaves are put into a chopping cavity between the fixed cylinder and the rotating tank. Then, the spur gear is driven to rotate by the output end of the driving motor, thereby driving the gear ring and the rotating tank to rotate. The multiple leaf cutting blades inside the rotating tank are used to rotate rapidly around the fixed cylinder, so that the leaf cutting blade and the fixed cutting blade rotate and stagger to chop the plant flowers and leaves. At the same time, the output end of the servo motor drives the rotating shaft and the root cutting blade to rotate, so that the multiple root cutting blades and the fixed cutting blade rotate and stagger to cut the plant rhizome. The juice flowing out during the chopping of flowers and leaves will flow along the surface of the centrifugal shell, and the chopped plant flowers and leaves will be centrifuged by the rotating tank. Then, the plant juice generated by centrifugation is filtered by the centrifugal filter plate, and the filtered plant medicinal liquid material will be centrifuged into the tank body, which is conducive to centrifugal extraction of the medicinal liquid in the flowers and leaves of the Podophyllum plant.

[0016] 2. The juice pressing ring plate is driven to rotate synchronously by the rotating tank, thereby driving the embedded slider at the end of the L-shaped rod to slide in the reciprocating spiral groove, and then the juice pressing ring plate can be driven to rise and fall reciprocally through the L-shaped rod. Since the multiple sweeping blades on the outer wall of the fixed cylinder will rotate relative to the rotating tank, it is convenient to sweep the centrifuged flower and leaf medicine residue between the juice pressing ring plate and the truncated cone. The flower and leaf medicine residue rolls down to the top of the filter press plate along the truncated cone. When the juice pressing ring plate is pressed down, the centrifuged flower and leaf medicine residue is filtered, and the pressed plant medicine liquid drips into the tank body through the filter press plate. During the descent of the juice pressing ring plate, the gap between the juice pressing ring plate and the truncated cone gradually decreases. Therefore, on the one hand, a closed condition can be formed to improve the compactness during filtration. On the other hand, when the juice pressing ring plate rises, new flower and leaf medicine residue will be swept into the pressing space again. The reciprocatingly lifted juice pressing ring plate can fully extract the medicine liquid in the flower and leaf medicine residue.

[0017] 3. After the rhizomes of the Podophyllum plants are cut into particles, they will fall into the expanding tube. Since the limited position cavity is arranged inside the juice pressing ring plate to limit the sliding rod, the sliding rod can drive the positioning ring to rise and fall synchronously with the juice pressing ring plate. When the positioning ring descends, it drives the root pressing circular plate to squeeze the rhizomes inside the expanding tube, so that the medicinal liquid in the rhizomes of the Podophyllum plants can also be squeezed out, and the medicinal liquid is filtered through the filter holes on the outer wall of the expanding tube. Since the linkage shaft and the root pressing circular plate are slidably sleeved, the root pressing circular plate will also rotate in the positioning ring when it descends, so the arc-shaped cutter at the bottom of the root pressing circular plate can squeeze the plant. The rhizomes of plants are cut into two sections, which is convenient for chopping the uncut rhizomes again, thereby facilitating improving the effect of squeezing and extracting the juice from the rhizomes of plants. Through the above operation, the medicinal juice of the flowers, leaves and rhizomes of the genus Podophyllum can be simultaneously squeezed and filtered to extract the medicinal juice, and the obtained medicinal liquid can be used to separate podophyllotoxin by decoction. Since the medicinal liquid obtained by filtration has less impurities, the medicinal substance obtained after decoction is convenient to filter, which speeds up the separation of podophyllotoxin. The medicinal substances in the flowers, leaves and rhizomes of plants can be extracted simultaneously by the juice squeezing mechanism, thereby avoiding the waste of effective medicinal resources.

[0018] 4. When the root pressing circular plate descends to gradually approach the sealing circular block, the two extrusion springs gradually shrink under the action of pressure, and then the granular plant rhizomes can be squeezed and dropped from the opening between the sealing circular block and the connecting tube, and then the servo motor 2 drives the crushing knife shaft to rotate rapidly to perform the third step of crushing the granular plant rhizomes, so that the rhizomes can be broken into powder, and at the same time, hot air is introduced into the crushing cylinder through the hot air blower, and the rhizome powder is dried by the hot air. The circulation pipe is provided to facilitate the circulation of hot air in it to dry the powder, so as to facilitate the rapid removal of moisture in the powder. The inclined upward end of the circulation pipe can reversely cut the rhizomes that have not been completely crushed and cut again under the action of gravity. After drying, the solenoid valve 2 is closed, and the dried rhizome powder is quickly discharged under the action of airflow after opening the solenoid valve 1. The fully dried plant rhizome powder can improve the dissolution effect of the powder and the solvent when combined with solvents such as methanol or ethanol, so it is beneficial to increase the separation amount of podophyllotoxin medicinal materials in the plant rhizomes. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the overall structure of the present invention; Figure 2 It is a schematic diagram of the overall top view structure of the present invention; Figure 3 It is a schematic diagram of the internal cross-sectional structure of the tank body in the present invention; Figure 4 It is a schematic diagram of the structure of the chopping centrifugal mechanism in the present invention; Figure 5 It is a schematic diagram of the connection structure of the fixed cylinder in the present invention; Figure 6 It is a schematic diagram of the bottom structure of the rotating tank in the present invention; Figure 7 It is a schematic diagram of the structure of the juice pressing mechanism in the present invention; Figure 8 It is a schematic diagram of the rotating shaft connection structure of the present invention; Fig. 9 It is a schematic diagram of the internal structure of the expanded tube in the present invention; Fig.10 It is a schematic diagram of the structure of the powder drying mechanism in the present invention; Fig.11 It is a schematic diagram of the cross-sectional structure of the grinding cylinder in the present invention.

[0020] In the figure: 100, chopping centrifugal mechanism; 101, tank body; 102, rotating tank; 103, support frame; 104, filter plate; 105, gear ring; 106, spur gear; 107, drive motor; 108, centrifugal shell; 109, centrifugal filter plate; 110, leaf cutting blade; 111, fixed cylinder; 112, fixed cutting blade 1; 113, sweeping blade; 114, fixed cutting blade 2; 115, limit groove; 200, juice pressing mechanism; 201, fixed ring plate; 202, mounting frame; 203, reciprocating spiral groove; 204, servo motor 1; 205, rotating shaft; 206, root cutting blade; 207, coupling Moving shaft; 208, embedded slider; 209, L-shaped rod; 210, juice pressing ring plate; 211, limiting cavity; 212, sliding rod; 213, positioning ring; 214, rooting circular plate; 215, arc-shaped cutter; 216, expanding cylinder; 217, filter hole; 218, vertical groove; 219, frustum; 300, powder drying mechanism; 301, connecting cylinder; 302, crushing cylinder; 303, servo motor 2; 304, crushing knife shaft; 305, hot air blower; 306, circulation pipe; 307, powder outlet pipe; 308, solenoid valve 1; 309, solenoid valve 2; 310, sealing round block; 311, extrusion spring. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0022] See also Figure 1-11In an embodiment of the present invention, a podophyllotoxin separation and purification device includes: a chopping centrifugal mechanism 100, a juice pressing mechanism 200, and a powder drying mechanism 300. The chopping centrifugal mechanism 100 is used to chop the rhizomes and flowers and leaves of the genus Podophyllum; the juice pressing mechanism 200 is used to squeeze the juice in the chopped rhizomes and flowers and leaves, and the juice pressing mechanism 200 includes a fixed ring plate 201, and the top of the fixed ring plate 201 is fixedly connected to a mounting frame 202. A reciprocating spiral groove 203 is provided on the inner wall of the fixed ring plate 201, and an embedded slider 208 is slidably embedded in the reciprocating spiral groove 203. The embedded slider 208 slides in the reciprocating spiral groove 203, and then can pass through The L-shaped rod 209 drives the juice pressing ring plate 210 to move up and down, the end of the embedded slider 208 is fixedly connected to the L-shaped rod 209, the bottom end of the L-shaped rod 209 is fixedly connected to the juice pressing ring plate 210, a limited cavity 211 is provided inside the juice pressing ring plate 210, a limited ring is rotatably sleeved in the limited cavity 211, a slide rod 212 is fixedly connected to the inner wall of the limited ring, a positioning ring 213 is fixedly connected to the end of the slide rod 212, a root pressing circular plate 214 is rotatably sleeved in the positioning ring 213, a plurality of arc-shaped cutters 215 are fixedly connected to the bottom of the root pressing circular plate 214 at equal distances, and the arc-shaped cutters 215 at the bottom of the root pressing circular plate 214 can perform two-stage cutting when squeezing plant roots and stems; A rotating shaft 205 is provided at the center of the fixed cylinder 111, and a plurality of root cutting blades 206 are fixedly connected to the outer wall of the rotating shaft 205 at equal intervals in an annular manner, and a plurality of fixed cutting blades 2 114 are fixedly connected to the inner wall of the fixed cylinder 111 at equal intervals in an annular manner, and an output end of a servo motor 1 204 is fixedly connected to the top of the rotating shaft 205, and a linkage shaft 207 is fixedly connected to the bottom of the rotating shaft 205, and a root pressing circular plate 214 is slidably connected to the linkage shaft 207. Two limiting grooves 115 are symmetrically provided on the inner wall of the rotating tank 102, and a juice pressing ring plate 210 is slidably connected to the limiting grooves 115. The bottom of the fixed cylinder 111 is fixedly connected with a flared cylinder 216 connected to the inside thereof, and a truncated cone 219 is fixedly sleeved on the outer wall of the flared cylinder 216. During the descent of the juice pressing ring plate 210, the gap between the truncated cone 219 gradually decreases, so on the one hand, a closed condition can be formed to improve the compactness during the filter pressing, and on the other hand, when the juice pressing ring plate 210 rises, new flower and leaf medicine residues will be swept into the pressing space again, and the root pressing circular plate 214 is slidably sleeved in the flared cylinder 216, and a vertical groove 218 is provided on the flared cylinder 216, and the sliding rod 212 is slidably connected with the vertical groove 218, and a plurality of filter holes 217 are equidistantly provided in an annular manner on the outer wall of the flared cylinder 216. The powder drying mechanism 300 is used to crush plant rhizomes into powder and perform a cyclic drying process on the powder.

[0023] Specifically, the rotating tank 102 drives the juice pressing ring plate 210 to rotate synchronously, thereby driving the embedded slider 208 at the end of the L-shaped rod 209 to slide in the reciprocating spiral groove 203, and then the juice pressing ring plate 210 can be driven to rise and fall reciprocatingly through the L-shaped rod 209. Since the multiple sweeping blades 113 on the outer wall of the fixed cylinder 111 rotate relative to the rotating tank 102, it is convenient to sweep the centrifuged flower and leaf medicine residue to between the juice pressing ring plate 210 and the truncated cone 219, and the flower and leaf medicine residue rolls along the truncated cone 219 to the filter press plate 104. At the top, the centrifuged flower and leaf medicine residue is filtered by the downward pressure of the juice pressing ring plate 210, and the squeezed plant medicine liquid drips into the tank body 101 through the filter pressing plate 104. During the downward process of the juice pressing ring plate 210, the gap between the juice pressing ring plate 210 and the truncated cone 219 gradually decreases. Therefore, on the one hand, a closed condition can be formed to improve the compactness during the filtration. On the other hand, when the juice pressing ring plate 210 rises, new flower and leaf medicine residue will be swept into the squeezing space again. The reciprocating lifting and lowering juice pressing ring plate 210 can fully extract the medicine liquid in the flower and leaf medicine residue. After the rhizomes of the Podophyllum plant are cut into particles, they will fall into the expanding tube 216. Since the limited position cavity 211 is set inside the juice pressing ring plate 210 to limit the sliding rod 212, the sliding rod 212 can drive the positioning ring 213 to rise and fall synchronously with the juice pressing ring plate 210. When the positioning ring 213 descends, it drives the root pressing circular plate 214 to squeeze the rhizomes inside the expanding tube 216, so that the medicinal liquid in the rhizomes of the Podophyllum plant can also be squeezed out, and the medicinal liquid is filtered through the filter holes 217 on the outer wall of the expanding tube 216. Since the linkage shaft 207 and the root pressing circular plate 214 are slidably connected, the root pressing circular plate 214 will also rotate in the positioning ring 213 when it descends. Therefore, the arc-shaped cutter 215 at the bottom of the root pressing circular plate 214 can cut the plant rhizomes into two sections when squeezing them, which is convenient for re-chopping the uncut rhizomes, thereby helping to improve the effect of squeezing and extracting the plant rhizomes. Through the above operation, the medicinal juice of the flowers, leaves and rhizomes of the genus Podophyllum can be simultaneously filtered and extracted, and the obtained medicinal liquid can be used to separate podophyllotoxin by decoction. Since the medicinal liquid obtained by filtration has less impurities, the medicinal substance obtained after decoction is convenient to filter, which speeds up the separation of podophyllotoxin. The medicinal substances in the flowers, leaves and rhizomes of the plant can be extracted simultaneously through the juice pressing mechanism 200, thereby avoiding the waste of effective medicinal resources. Embodiment 1

[0024] like Figure 4-6As shown, in this embodiment, the shredding centrifugal mechanism 100 includes a tank body 101 fixedly connected to the mounting frame 202, a rotating tank 102 is rotatably sleeved at the center position of the tank body 101, a filter press plate 104 is screwed and sleeved at the bottom end of the rotating tank 102, a drain pipe connected to the inside of the tank body 101 is fixedly connected at the bottom, a support frame 103 is fixedly arranged on the outside of the tank body 101, a gear ring 105 is fixedly sleeved on the outer wall of the rotating tank 102, a spur gear 106 is meshed and connected to one side of the gear ring 105, an output end of a drive motor 107 is fixedly connected at the center position of the spur gear 106, and the drive motor 107 is fixedly connected to the inner wall of the tank body 101. A plurality of centrifugal shells 108 are fixedly connected to the inner ring of the rotating tank 102 at equal distances, and a centrifugal filter plate 109 is fixedly connected to each of the plurality of centrifugal shells 108. A plurality of leaf cutting blades 110 are fixedly connected at equal distances on the inner walls of the plurality of centrifugal shells 108. The leaf cutting blades 110 and the fixed cutting blades 112 rotate and alternately to chop the plant leaves and flowers. A fixed cylinder 111 is sleeved at the center position of the rotating tank 102. The top of the fixed cylinder 111 is fixedly connected to the bottom of the mounting frame 202. A plurality of fixed cutting blades 112 are fixedly connected at equal distances in an annular manner on the outer wall of the fixed cylinder 111. A plurality of sweeping blades 113 are fixedly connected at equal distances in an annular manner on the bottom end of the fixed cylinder 111. The plurality of sweeping blades 113 on the outer wall of the fixed cylinder 111 will rotate relative to the rotating tank 102, so as to facilitate sweeping the flower and leaf residues after centrifugation to between the juice pressing ring plate 210 and the frustum 219.

[0025] In this embodiment, the rhizome of Podophyllum spp. is put into the fixed cylinder 111, and the flower and leaves are put into the chopping cavity between the fixed cylinder 111 and the rotating tank 102, and then the spur gear 106 is driven to rotate by the output end of the driving motor 107, thereby driving the gear ring 105 and the rotating tank 102 to rotate, and the multiple leaf cutting blades 110 inside the rotating tank 102 are used to rotate rapidly around the fixed cylinder 111, so that the leaf cutting blades 110 and the fixed cutting blades 112 rotate alternately to chop the flower and leaves of the plant, and at the same time, the servo motor 12 is used to rotate the spur gear 106. The output end 04 drives the rotating shaft 205 and the root cutting blade 206 to rotate, so that the multiple root cutting blades 206 and the fixed cutting blade 114 rotate and stagger to cut the plant rhizomes. The juice flowing out during the chopping process of the flowers and leaves will flow along the surface of the centrifugal shell 108, and the chopped plant flowers and leaves will be centrifuged by the rotating tank 102, and then the plant juice produced by the centrifugation will be filtered through the centrifugal filter plate 109. The filtered plant medicinal liquid material will be centrifuged into the tank body 101, which is conducive to the centrifugal extraction of the medicinal liquid in the flowers and leaves of the Podophyllum plant. Embodiment 2

[0026] like Figure 10-11As shown, in this embodiment, the powder drying mechanism 300 includes a connecting cylinder 301 fixedly connected to the bottom end of the expanding cylinder 216, a crushing cylinder 302 fixedly connected to the bottom end of the connecting cylinder 301, a servo motor 2 303 fixedly connected to the end of the crushing cylinder 302, a crushing knife shaft 304 fixedly connected to the output end of the servo motor 2 303, an output end of a hot air blower 305 fixedly connected to the side wall of the crushing cylinder 302, and an end of the crushing cylinder 302 fixedly connected to a circulation pipe 306 connected to the interior thereof, and hot air can be used to dry the rhizome powder, and the circulation pipe 306 is provided to facilitate the circulation of hot air therein to dry the powder, a powder outlet pipe 307 is fixedly connected to the circulation pipe 306, an electromagnetic valve 1 308 is fixedly provided in the powder outlet pipe 307, and an electromagnetic valve 2 309 is fixedly provided in the circulation pipe 306. A sealing block 310 is provided at the top of the connecting tube 301, and two extrusion springs 311 fixedly connected to the inner wall of the connecting tube 301 are symmetrically fixedly connected to the bottom of the sealing block 310. Under the action of pressure, the two extrusion springs 311 gradually shrink, and then the granular plant roots can be squeezed and dropped from the opening between the sealing block 310 and the connecting tube 301.

[0027] In specific implementation, when the root pressing circular plate 214 descends to gradually approach the sealing circular block 310, the two squeezing springs 311 gradually shrink under the action of pressure, and then the granular plant rhizomes can be squeezed and dropped from the opening between the sealing circular block 310 and the connecting cylinder 301, and then the servo motor 2 303 drives the crushing knife shaft 304 to rotate rapidly to perform the third step of crushing treatment on the granular plant rhizomes, so that the rhizomes can be broken into powder, and at the same time, hot air is introduced into the crushing cylinder 302 through the hot air blower 305, and the rhizome powder is dried by the hot air energy, and the rhizome powder is dried by the provision of The circulation pipe 306 can facilitate hot air circulation therein to dry the powder, thereby facilitating the rapid removal of moisture from the powder. The inclined upward end of the circulation pipe 306 can reversely flow and re-cut the rhizomes that have not been completely crushed and cut under the action of gravity. After drying, the solenoid valve 2 309 is closed, and the solenoid valve 1 308 is opened to allow the dried rhizome powder to be quickly discharged under the action of airflow. The fully dried plant rhizome powder can be combined with solvents such as methanol or ethanol, thereby improving the dissolution effect of the powder and the solvent, thereby facilitating the increase in the separation amount of podophyllotoxin medicinal materials in the plant rhizomes.

[0028] It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above and that the invention can be implemented in other specific forms without departing from the spirit or essential features of the invention. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations falling within the meaning and scope of the equivalent elements of the claims be included in the invention. Any reference numeral in a claim should not be considered as limiting the claim to which it relates.

[0029] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A podophyllotoxin separation and purification device, characterized in that: include: A chopping centrifugal mechanism (100), wherein the chopping centrifugal mechanism (100) is used to chop the rhizomes and flowers and leaves of a plant of the genus Podophyllum; A juice pressing mechanism (200) is used to squeeze juice from chopped rhizomes and flower leaves, and comprises a fixed ring plate (201), the top of which is fixedly connected to a mounting frame (202), an inner wall of which is provided with a reciprocating spiral groove (203), an embedded slider (208) slidably embedded in the reciprocating spiral groove (203), an end of which is fixedly connected to an L-shaped rod (209), and the inner wall of the embedded slider (208) is provided with a reciprocating spiral groove (203). The bottom end of the L-shaped rod (209) is fixedly connected to a juice pressing ring plate (210), a limiting cavity (211) is provided inside the juice pressing ring plate (210), a limiting ring is rotatably sleeved in the limiting cavity (211), a sliding rod (212) is fixedly connected to the inner wall of the limiting ring, a positioning ring (213) is fixedly connected to the end of the sliding rod (212), a rooting circular plate (214) is rotatably sleeved in the positioning ring (213), and a plurality of arc-shaped cutting knives (215) are fixedly connected to the bottom of the rooting circular plate (214) at equal intervals. A powder drying mechanism (300) is used to crush plant rhizomes into powder and perform a cyclic drying process on the powder.

2. A podophyllotoxin separation and purification device according to claim 1, characterized in that: The chopping centrifugal mechanism (100) comprises a tank body (101) fixedly connected to a mounting frame (202); a rotating tank (102) is rotatably sleeved at the center position of the tank body (101); a filter press plate (104) is screwed sleeved at the bottom end of the rotating tank (102); a liquid discharge pipe connected to the inside of the tank body (101) is fixedly connected to the bottom of the tank body (101); a support frame (103) is fixedly arranged on the outside of the tank body (101); a gear ring (105) is fixedly sleeved on the outer wall of the rotating tank (102); a spur gear (106) is meshedly connected to one side of the gear ring (105); an output end of a drive motor (107) is fixedly connected at the center position of the spur gear (106); and the drive motor (107) is fixedly connected to the inner wall of the tank body (101).

3. A podophyllotoxin separation and purification device according to claim 2, characterized in that: A plurality of centrifugal shells (108) are fixedly connected to the inner ring of the rotating tank (102) at equal distances, and a centrifugal filter plate (109) is fixedly connected to each of the plurality of centrifugal shells (108).

4. A podophyllotoxin separation and purification device according to claim 3, characterized in that: A plurality of leaf cutting blades (110) are fixedly connected at equal distances on the inner walls of the plurality of centrifugal shells (108); a fixed cylinder (111) is sleeved at the center of the rotating tank (102); the top of the fixed cylinder (111) is fixedly connected to the bottom of the mounting frame (202); a plurality of fixed cutting blades (112) are fixedly connected at equal distances in an annular manner on the outer wall of the fixed cylinder (111); and a plurality of sweeping blades (113) are fixedly connected at equal distances in an annular manner at the bottom end of the fixed cylinder (111).

5. A podophyllotoxin separation and purification device according to claim 4, characterized in that: A rotating shaft (205) is provided at the center of the fixed cylinder (111); a plurality of root cutting blades (206) are fixedly connected in an annular manner at equal intervals on the outer wall of the rotating shaft (205); a plurality of fixed cutting blades (114) are fixedly connected in an annular manner at equal intervals on the inner wall of the fixed cylinder (111); the top end of the rotating shaft (205) is fixedly connected to the output end of a servo motor (204); the bottom end of the rotating shaft (205) is fixedly connected to a linkage shaft (207); and the root pressing circular plate (214) is slidably sleeved with the linkage shaft (207).

6. A podophyllotoxin separation and purification device according to claim 4, characterized in that: Two limiting grooves (115) are symmetrically provided on the inner wall of the rotating tank (102), and the juice pressing ring plate (210) is slidably engaged with the limiting grooves (115).

7. A podophyllotoxin separation and purification device according to claim 4, characterized in that: The bottom of the fixed cylinder (111) is fixedly connected to a flaring cylinder (216) which is in communication with the interior thereof; the rooting circular plate (214) is slidably sleeved in the flaring cylinder (216); a vertical groove (218) is provided on the flaring cylinder (216); the sliding rod (212) is slidably connected to the vertical groove (218); and a plurality of filter holes (217) are equidistantly provided in an annular shape on the outer wall of the flaring cylinder (216).

8. A podophyllotoxin separation and purification device according to claim 7, characterized in that: A truncated cone (219) is fixedly sleeved on the outer wall of the flaring tube (216).

9. A podophyllotoxin separation and purification device according to claim 8, characterized in that: The powder drying mechanism (300) comprises a connecting cylinder (301) fixedly connected to the bottom end of the expanding cylinder (216); a pulverizing cylinder (302) fixedly connected to the bottom end of the connecting cylinder (301); a servo motor 2 (303) fixedly connected to the end of the pulverizing cylinder (302); a pulverizing blade shaft (304) fixedly connected to the output end of the servo motor 2 (303); an output end of a hot air blower (305) fixedly connected to the side wall of the pulverizing cylinder (302); an end of the pulverizing cylinder (302) fixedly connected to a circulation pipe (306) connected to the inside of the pulverizing cylinder (302); a powder outlet pipe (307) fixedly connected to the circulation pipe (306); a solenoid valve 1 (308) fixedly arranged in the powder outlet pipe (307); and a solenoid valve 2 (309) fixedly arranged in the circulation pipe (306).

10. A podophyllotoxin separation and purification device according to claim 9, characterized in that: A sealing round block (310) is arranged at the top of the connecting cylinder (301), and two extrusion springs (311) fixedly connected to the inner wall of the connecting cylinder (301) are symmetrically fixedly connected to the bottom of the sealing round block (310).

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