Processing technology of vitamin, ginseng and zinc capsules

Abstract

The invention relates to the field of medicine preparation, and particularly discloses a processing technology of vitamin, ginseng and zinc capsules, which comprises the following steps: uniformly mixing vitamin, ginseng composition, zinc sulfate, pollen, bromelain and bonding liquid to obtain a core material; uniformly mixing the cellulose acetate solution and dietary fibers according to a mass ratio of 100: (2-5) to obtain a compound solution; weighing glutamine, oat polypeptide, polysaccharide and water according to a mass ratio of 1: (1-3): (2-8): (90-120), and uniformly mixing to obtain a mixed solution; preparing a glue solution with the concentration of 0.5-1%; uniformly mixing the compound solution, the mixed solution and the glue solution according to a mass ratio of 100: (30-50): (20-50) to obtain a film forming solution; pouring the film forming liquid into a mold, drying and forming to obtain a capsule shell; filling the capsule shell with the core material to obtain a finished product; the composition has the advantages of being released in intestinal tracts, promoting effective components to rapidly enter blood circulation, improving the absorption efficiency and utilization rate of the effective components by bodies and being suitable for middle-aged and elderly people.

Description

Technical Field

[0001] The present application relates to the field of drug preparation, and more specifically, to a processing technology of vitamin C zinc capsules. Background Art

[0002] Red ginseng zinc capsule is a health care medicine. It contains a variety of active ingredients and is covered with a capsule body. The existence of the capsule body ensures that the active ingredients can achieve a sustained release effect. The zinc and vitamins in the active ingredients can enhance the body's immunity and resistance, and help reduce the prosperity of diseases. Red ginseng can regulate cardiopulmonary function, and can also regulate visual acuity and hearing. At the same time, the active ingredients also have the function of regulating the endocrine system, which helps to alleviate endocrine disorders.

[0003] Weishen Zinc Capsules are generally taken by middle-aged and elderly people, but their gastrointestinal regulatory function is weakened, and their absorption efficiency and utilization rate of active ingredients are also low; the active ingredients in Weishen Zinc Capsules are easily irritated to the gastric mucosa when released in the stomach, which can easily cause stomach discomfort symptoms such as nausea and vomiting, and when the active ingredients are exposed to gastric acid for a long time, the drug ingredients are easily lost, thereby affecting the absorption efficiency and utilization rate of the active ingredients; while release in the intestine can not only reduce stomach irritation, but also the vitamins and minerals in Weishen Zinc Capsules are more easily absorbed in the intestine. The intestinal mucosal layer is rich in blood vessels and lymphatic vessels, which helps the active ingredients to quickly enter the blood circulation, thereby improving the absorption efficiency and utilization rate of the active ingredients in Weishen Zinc Capsules in the middle-aged and elderly population.

[0004] Therefore, how to prepare a new vitamin C zinc capsule so that it is not easy to release the active ingredients in the stomach but release them in the intestines, promote the rapid entry of the active ingredients into the blood circulation, improve the body's absorption efficiency and utilization rate of the active ingredients, and be suitable for middle-aged and elderly people is a problem to be solved. Summary of the invention

[0005] In order to prepare a new vitamin C zinc capsule, which is not easy to release the active ingredients in the stomach but is released in the intestine, promotes the active ingredients to quickly enter the blood circulation, improves the body's absorption efficiency and utilization rate of the active ingredients, and is suitable for middle-aged and elderly people, the present application provides a processing technology for vitamin C zinc capsules.

[0006] The present application provides a processing technology for vitamin C zinc capsules, which adopts the following technical solution: A processing technology of Weishen Zinc Capsules comprises the following steps: S1, mixing vitamins, ginseng composition, zinc sulfate, pollen, bromelain, and adhesive liquid uniformly to obtain a core material; S2. Mix the cellulose acetate solution and dietary fiber at a mass ratio of 100:2-5 to obtain a composite solution; weigh glutamine, oat polypeptide, polysaccharide, and water at a mass ratio of 1:1-3:2-8:90-120 and mix them evenly to obtain a mixed solution; add water to the colloid, heat it up and stir until it is completely dissolved to obtain a glue solution with a concentration of 0.5-1%; mix the composite solution, the mixed solution, and the glue solution at a mass ratio of 100:30-50:20-50 and stir them evenly to obtain a film-forming solution; S3, pouring the film-forming liquid into a mold, drying and molding to obtain a capsule shell; S4, pouring the core material into the capsule shell to obtain the finished product.

[0007] By adopting the above technical scheme, the good acid resistance of cellulose acetate and glue is utilized to make the vitamin ginseng zinc capsule not easily decomposed in the stomach, thereby ensuring that the vitamin ginseng zinc capsule is decomposed in the intestine; utilizing the dispersion and filling effect of dietary fiber, the digestive enzymes such as protease and polysaccharidase in the intestine are promoted to quickly decompose the substances around the dietary fiber, so that the capsule shell is quickly decomposed, and the glutamine, oat polypeptide, polysaccharide and dietary fiber in the decomposed large-particle capsule shell are further released, thereby increasing the contact area between glutamine, oat polypeptide, polysaccharide and dietary fiber and the digestive enzymes in the intestine, the polysaccharide can be gradually decomposed by the polysaccharidase in the intestine, and the protein can be decomposed by the protease in the intestine, thereby realizing the rapid decomposition of the capsule shell; in the process of gradual decomposition of the capsule shell, the core material is gradually released, and the nutrients in the vitamins, ginseng composition, zinc sulfate and pollen can be gradually absorbed and utilized by the intestine, and the raw materials containing protein are further decomposed by bromelain and the protease in the intestine, thereby promoting the rapid entry of the effective ingredients into the blood circulation, and improving the body's absorption efficiency and utilization rate of the effective ingredients in the vitamin ginseng zinc capsule.

[0008] Dietary fiber, oat peptides and glutamine are combined. Dietary fiber and oat peptides can promote intestinal peristalsis and regulate intestinal function in the elderly. Oat peptides can promote the growth and reproduction of beneficial bacteria in the intestine, increase intestinal flora, and further improve the intestinal decomposition efficiency of nutrients in the core material. Combined with glutamine, it can protect the intestinal mucosal structure, enhance intestinal cell vitality, promote intestinal absorption of water, and increase intestinal absorption of chloride and sodium, further promoting the nutrients in the core material of the Weishen Zinc Capsule to quickly enter the blood circulation, and improve the absorption efficiency and utilization rate of the effective ingredients in the Weishen Zinc Capsule for the middle-aged and elderly.

[0009] Preferably, the core material comprises the following raw materials in parts by weight: 10-15 parts of vitamins, 40-60 parts of ginseng composition, 0.5-1 part of zinc sulfate, 10-15 parts of pollen, 0.5-1 part of bromelain, and 20-40 parts of a binder; the binder is composed of starch liquid and fucoidan liquid in a mass ratio of 1:0.5-1.

[0010] By adopting the above technical scheme, vitamins, ginseng composition and pollen are coordinated to ensure that the vitamin ginseng zinc capsule can enhance cardiopulmonary function and improve body immunity. The release of bromelain in the core material can increase the content of intestinal protease, further promote the decomposition of proteins in colloids, ginseng composition and other substances, and improve the intestinal absorption rate and utilization rate of nutrients in the vitamin ginseng zinc capsule.

[0011] The starch liquid and fucoidan liquid have a certain viscosity, which can bond the ingredients in the core material together to form small particles. The small particles are filled in the capsule shell to realize the preparation of the vitamin C zinc capsule. During the release of the core material, the ingredients in the core material are evenly distributed, thereby ensuring the uniformity of digestion and absorption; combined with the digestion effect of amylase on starch and the digestion effect of polysaccharidase on fucoidan, it is further ensured that the nutrients in the core material are quickly absorbed by the intestines and transported throughout the body with the blood, thereby improving the intestinal absorption rate and utilization rate of the nutrients in the vitamin C zinc capsules.

[0012] Preferably, the vitamins consist of vitamin E and vitamin C in a mass ratio of 1:0.2-0.5.

[0013] By adopting the above technical scheme, vitamin C can enhance the body's immunity, improve the metabolism of fats and lipids, and prevent cardiovascular diseases; vitamin E has the effect of promoting blood circulation, further promoting the effective ingredients in the core material of the vitamin C zinc capsule to quickly enter the blood circulation, and improve the body's absorption efficiency and utilization rate of the effective ingredients, which is suitable for middle-aged and elderly people.

[0014] Preferably, the ginseng composition is prepared from ginseng powder and polyethylene glycol 2000 in a mass ratio of 1:0.1-0.2.

[0015] By adopting the above technical scheme and utilizing the better pore-forming effect of polyethylene glycol 2000, the rapid decomposition and absorption of ginseng powder in the intestine can be promoted, and the extraction rate of nutrients in ginseng can be increased, thereby ensuring the absorption efficiency and utilization rate of nutrients in the finished ginseng zinc capsule, which is suitable for middle-aged and elderly people.

[0016] Preferably, the pollen is pine pollen.

[0017] By adopting the above technical scheme, pine pollen contains a variety of antioxidant ingredients, such as superoxide dismutase, vitamin E, carotene and trace element selenium, etc. These substances can resist the erosion of external ultraviolet rays, enhance the body's metabolic capacity, maintain the vitality of cell regeneration, thereby achieving the effect of delaying aging; pine pollen is rich in nutrients such as polysaccharides and flavonoids, which can provide the body with necessary nutrition, enhance the function of the immune system, and improve resistance; pine pollen is rich in vitamins and dietary fiber, which can effectively promote gastrointestinal motility, help digestion and absorption of food, play a role in moisturizing the intestines and promoting bowel movements, and help improve gastrointestinal function, so that Weishen Zinc Capsules can be suitable for middle-aged and elderly people and are not prone to discomfort.

[0018] Preferably, the dietary fiber consists of citrus dietary fiber and white kidney bean dietary fiber in a mass ratio of 1:0.2-0.5.

[0019] By adopting the above technical scheme, citrus dietary fiber can regulate blood sugar and cholesterol levels in the intestine and balance the sugar content, while white kidney bean dietary fiber can slow down the absorption rate of carbohydrates to ensure that too much sugar is not easily produced in the blood; the presence of sugar in the capsule shell can increase the decomposition rate of the capsule shell, while excessive sugar will increase the osmotic pressure in the intestine, causing water to flow into the intestinal cavity, affecting the absorption of nutrients in the core material of the vitamin zinc capsule in the intestine, and sugar may also stimulate blood circulation and accelerate the excretion of drugs through the circulatory system, thereby reducing the residence time and concentration of the drug in the blood and reducing the efficacy of the drug.

[0020] Citrus dietary fiber and white kidney bean dietary fiber can promote intestinal peristalsis, speed up the decomposition and digestion rate of the core material in the intestine, and improve discomfort symptoms such as constipation. At the same time, it can also promote the growth and reproduction of bacteria, improve the intestinal environment, and enable middle-aged and elderly people with poor intestinal function to take vitamin zinc capsules without easily causing discomfort.

[0021] Preferably, the average particle size of the dietary fiber is 20-80 μm.

[0022] By adopting the above technical solution, the size of dietary fiber is limited, which is not easy to affect the digestion and absorption rate due to being too large, nor is it easy to be unable to accelerate the decomposition rate of the vitamin ginseng zinc capsule due to being too small, thereby ensuring the absorption rate and utilization rate of the vitamin ginseng zinc capsule in the intestine.

[0023] Preferably, the glutamine is L-glutamine.

[0024] By adopting the above technical solution, L-glutamine can promote the intestinal absorption of nutrients, help improve malnutrition caused by intestinal dysfunction or disease, and L-glutamine can improve intestinal peristalsis and relieve intestinal symptoms such as diarrhea and constipation; it can also promote the proliferation and repair of intestinal epithelial cells and maintain the integrity of the intestinal barrier function, thereby protecting the intestine from harmful substances and pathogens; at the same time, L-glutamine can improve the intestinal environment, enhance the intestinal absorption capacity of drugs, and help the drugs to work better.

[0025] Preferably, the polysaccharide consists of maltose and fucoidan in a mass ratio of 1:0.2-0.5.

[0026] By adopting the above technical solution, maltose can promote the production of digestive enzymes, help food to be better decomposed in the digestive tract, and thus promote digestion. Maltose can improve the intestinal microbial community and enhance the body's disease resistance. Combined with fucoidan, fucoidan has the effects of removing Helicobacter pylori, protecting gastric mucosa and treating gastric ulcers, creating favorable conditions for intestinal absorption of drugs. At the same time, fucoidan can enhance the body's immune function and promote the activation and proliferation of macrophages. This helps to enhance the immune barrier function of the intestine and prevent pathogens from interfering with drug absorption.

[0027] Preferably, the colloid consists of gum arabic and linseed gum in a mass ratio of 1:0.5-1.

[0028] By adopting the above technical scheme, gum arabic and flaxseed gum can increase the viscosity of the film-forming liquid and improve the stability of the capsule shell. In addition, gum arabic and flaxseed gum help to increase the contact between the drug and the intestinal mucosa and promote the absorption of the drug. Flaxseed gum can also combine with cholesterol and heavy metal ions in the intestine to reduce their absorption rate, which helps to maintain intestinal health.

[0029] In summary, this application has the following beneficial effects: 1. Utilizing the good acid resistance of cellulose acetate and glue, the vitamin ginseng zinc capsule is not easily decomposed in the stomach, ensuring that the vitamin ginseng zinc capsule is decomposed in the intestine; combined with dietary fiber, glutamine, oat polypeptide, and polysaccharide, the capsule shell is promoted to be decomposed in the intestine, and the core material is gradually released. The nutrients in vitamins, ginseng composition, zinc sulfate, and pollen can be gradually absorbed and utilized by the intestine, promoting the effective ingredients to quickly enter the blood circulation, and improving the body's absorption efficiency and utilization of the effective ingredients in the vitamin ginseng zinc capsule.

[0030] 2. Dietary fiber, oat peptides and glutamine work together. Dietary fiber and oat peptides can promote intestinal peristalsis, regulate intestinal function of middle-aged and elderly people, and oat peptides can promote the growth and reproduction of beneficial bacteria in the intestine; combined with glutamine, it can enhance the vitality of intestinal cells, increase the intestinal absorption of chloride and sodium, and further promote the nutrients in the core material of the Weishen Zinc Capsule to quickly enter the blood circulation, thereby improving the absorption efficiency and utilization rate of the effective ingredients in the Weishen Zinc Capsule by the middle-aged and elderly.

[0031] 3. Citrus dietary fiber and white kidney bean dietary fiber can promote intestinal peristalsis, speed up the decomposition and digestion rate of the core material in the intestine, and improve discomfort symptoms such as constipation. At the same time, it can also promote the growth and reproduction of bacteria, improve the intestinal environment, and enable middle-aged and elderly people with poor intestinal function to take vitamin zinc capsules without easily causing discomfort. DETAILED DESCRIPTION

[0032] The present application is further described in detail below with reference to the embodiments. Example

[0033] Among the following raw materials, oat peptides were purchased from Xi'an Ruierli Bioengineering Co., Ltd. and are food grade; ginseng powder was purchased from Xi'an Youshuo Biotechnology Co., Ltd. and are food grade; pine pollen was purchased from Shandong Gushuo Biotechnology Co., Ltd. and are food grade; fucoidan was purchased from Guangdong Mingcheng Biotechnology Co., Ltd. and are food grade; cellulose acetate was purchased from Wuhan Lanabai Pharmaceutical Chemical Co., Ltd. and are pharmaceutical grade, cellulose diacetate; citrus dietary fiber was purchased from Xi'an Youshuo Biotechnology Co., Ltd. and are food grade; white kidney bean dietary fiber was purchased from Jiangsu Caiwei Biotechnology Co., Ltd. and are food grade; gum arabic and flaxseed gum were purchased from Jiangsu Caiwei Biotechnology Co., Ltd. and are food grade; other raw materials and equipment are commercially available.

[0034] Embodiment 1: A processing technology of Weishen Zinc Capsule: S1. Weigh 12kg of vitamins, 50kg of ginseng composition, 1kg of zinc sulfate, 12kg of pollen, and 1kg of bromelain, mix and stir evenly to obtain a mixture, add 30kg of binding liquid to the mixture at a uniform speed, stir the mixture continuously at a speed of 120r / min during the addition process, mix and stir evenly to obtain a core material; the vitamins are composed of vitamin E and vitamin C in a mass ratio of 1:0.4; 0.2kg of polyethylene glycol 2000 is evenly sprayed on the surface of 1kg of ginseng powder, and the ginseng composition is obtained by drying and dispersing until the ginseng powder does not stick to each other and agglomerate; the pollen is pine pollen; the binding liquid is composed of starch liquid and fucoidan liquid in a mass ratio of 1:1, the starch liquid is a starch aqueous solution with a mass fraction of 2%, the dissolution temperature of the starch aqueous solution is 60°C, and the fucoidan liquid is a fucoidan aqueous solution with a mass fraction of 2%; S2, placing cellulose acetate in acetone and stirring until the cellulose acetate is completely dissolved to obtain a cellulose acetate solution with a mass fraction of 2%, and uniformly adding 4 kg of dietary fiber to 100 kg of the cellulose acetate solution, wherein the dietary fiber is composed of citrus dietary fiber and white kidney bean dietary fiber in a mass ratio of 1:0.4, and the average particle size of the dietary fiber is 60 μm. The dietary fiber is added at a rate of 200 g / min. During the addition process, the cellulose acetate solution is continuously stirred at a speed of 200 r / min and mixed evenly to obtain a composite solution; weighing 1 kg Glutamine, 2kg oat polypeptide, 5kg polysaccharide and 100kg water are mixed, wherein the glutamine is L-glutamine, and the polysaccharide is composed of maltose and fucoidan in a mass ratio of 1:0.4, and stirred at a speed of 200r / min for 30min to obtain a mixed solution; water is added to the colloid, the temperature is raised to 70°C and stirred until the colloid is completely dissolved to obtain a 1% colloid solution, wherein the colloid is composed of gum arabic and flaxseed gum in a mass ratio of 1:1; 100kg of the composite solution, 40kg of the mixed solution and 30kg of the colloid solution are mixed and stirred evenly to obtain a film-forming solution; S3, pouring the film-forming liquid into a mold, drying and molding to obtain a capsule shell; S4. Pour the core material into the capsule shell, with the core material occupying 1 / 3 of the internal volume of the capsule shell, to obtain a finished product.

[0035] Embodiment 2: This embodiment differs from Embodiment 1 in that: S1. Weigh 10kg of vitamins, 40kg of ginseng composition, 0.5kg of zinc sulfate, 10kg of pollen, and 0.5kg of bromelain, mix and stir evenly to obtain a mixture, add 20kg of binding liquid to the mixture at a uniform speed, stir the mixture continuously at a speed of 120r / min during the addition process, mix and stir evenly to obtain a core material; the vitamins are composed of vitamin E and vitamin C in a mass ratio of 1:0.2; 0.1kg of polyethylene glycol 2000 is evenly sprayed on the surface of 1kg of ginseng powder, and the ginseng composition is obtained by drying and dispersing until the ginseng powder does not stick to each other and agglomerate; the pollen is pine pollen; the binding liquid is composed of starch liquid and fucoidan liquid in a mass ratio of 1:0.5, the starch liquid is a starch aqueous solution with a mass fraction of 2%, and the fucoidan liquid is a fucoidan aqueous solution with a mass fraction of 2%; S2, placing cellulose acetate in acetone and stirring until the cellulose acetate is completely dissolved to obtain a cellulose acetate solution with a mass fraction of 2%, and uniformly adding 2 kg of dietary fiber to 100 kg of the cellulose acetate solution, wherein the dietary fiber is composed of citrus dietary fiber and white kidney bean dietary fiber in a mass ratio of 1:0.2, and the average particle size of the dietary fiber is 20 μm. The dietary fiber is added at a rate of 200 g / min. During the addition process, the cellulose acetate solution is continuously stirred at a speed of 200 r / min and mixed evenly to obtain a composite solution; weighing 1 k g glutamine, 1kg oat polypeptide, 2kg polysaccharide, and 90kg water are mixed, wherein the glutamine is L-glutamine, and the polysaccharide is composed of maltose and fucoidan in a mass ratio of 1:0.2, and stirred at a speed of 200r / min for 30min to obtain a mixed solution; water is added to the colloid, the temperature is raised to 70°C, and stirred until it is completely dissolved to obtain a 1% colloid solution, wherein the colloid is composed of gum arabic and flaxseed gum in a mass ratio of 1:0.5; 100kg of the composite solution, 30kg of the mixed solution, and 20kg of the colloid solution are mixed and stirred evenly to obtain a film-forming solution; S3, pouring the film-forming liquid into a mold, drying and molding to obtain a capsule shell; S4. Pour the core material into the capsule shell, with the core material occupying 1 / 3 of the internal volume of the capsule shell, to obtain a finished product.

[0036] Embodiment 3: This embodiment differs from Embodiment 1 in that: S1. Weigh 15kg of vitamins, 60kg of ginseng composition, 1kg of zinc sulfate, 15kg of pollen, and 1kg of bromelain, mix and stir evenly to obtain a mixture, add 40kg of binding liquid to the mixture at a uniform speed, stir the mixture continuously at a speed of 120r / min during the addition process, mix and stir evenly to obtain a core material; the vitamins are composed of vitamin E and vitamin C in a mass ratio of 1:0.5; 0.2kg of polyethylene glycol 2000 is evenly sprayed on the surface of 1kg of ginseng powder, and the ginseng composition is obtained by drying and dispersing until the ginseng powder does not stick to each other and agglomerate; the pollen is pine pollen; the binding liquid is composed of starch liquid and fucoidan liquid in a mass ratio of 1:1, the starch liquid is a starch aqueous solution with a mass fraction of 2%, and the fucoidan liquid is a fucoidan aqueous solution with a mass fraction of 2%; S2, placing cellulose acetate in acetone and stirring until the cellulose acetate is completely dissolved to obtain a cellulose acetate solution with a mass fraction of 2%, and uniformly adding 5 kg of dietary fiber to 100 kg of the cellulose acetate solution, wherein the dietary fiber is composed of citrus dietary fiber and white kidney bean dietary fiber in a mass ratio of 1:0.5, and the average particle size of the dietary fiber is 80 μm. The dietary fiber is added at a rate of 200 g / min. During the addition process, the cellulose acetate solution is continuously stirred at a speed of 200 r / min and mixed evenly to obtain a composite solution; weighing 1 k g glutamine, 3kg oat polypeptide, 8kg polysaccharide, and 120kg water are mixed, wherein the glutamine is L-glutamine, and the polysaccharide is composed of maltose and fucoidan in a mass ratio of 1:0.5, and stirred at a speed of 200r / min for 30min to obtain a mixed solution; water is added to the colloid, the temperature is raised to 70°C, and stirred until it is completely dissolved to obtain a 1% colloid solution, wherein the colloid is composed of gum arabic and flaxseed gum in a mass ratio of 1:1; 100kg of the composite solution, 50kg of the mixed solution, and 50kg of the colloid solution are mixed and stirred evenly to obtain a film-forming solution; S3, pouring the film-forming liquid into a mold, drying and molding to obtain a capsule shell; S4. Pour the core material into the capsule shell, with the core material occupying 1 / 3 of the internal volume of the capsule shell, to obtain a finished product.

[0037] Embodiment 4: This embodiment differs from Embodiment 1 in that: The ginseng composition in the S1 core material does not contain polyethylene glycol 2000.

[0038] Embodiment 5: This embodiment differs from Embodiment 1 in that: S2 dietary fiber is citrus dietary fiber.

[0039] Comparative Example Comparative Example 1: The difference between this comparative example and Example 1 is that: No bromelain was added to the S1 core.

[0040] Comparative Example 2: The difference between this comparative example and Example 1 is that: No dietary fiber was added to S2.

[0041] Comparative Example 3: The difference between this comparative example and Example 1 is that: No mixed solution was added to S2.

[0042] Performance testing 1. Absorption efficiency and utilization rate detection The methods of Examples 1-5 and Comparative Examples 1-3 were used to prepare Weishen Zinc Capsules respectively; 90 rats with a weight difference of less than 0.5 kg and an average weight of 220 g, all of which were male, were selected and divided into 8 groups, with 10 rats in each group; the 8 groups of rats respectively ingested Weishen Zinc Capsules prepared in Examples 1-5 and Comparative Examples 1-3; 2 mL of blood was drawn from rats every 5 minutes starting from 30 minutes after the intake of the Weishen Zinc Capsule. The blood was tested for any active ingredient in the core material, including vitamins, ginseng composition, zinc sulfate, and pollen. The intake time was recorded. A short intake time indicated that the capsule shell decomposed quickly and the active ingredients in the core material could be released quickly, thereby improving the absorption efficiency of the Weishen Zinc Capsule by the human body. The time when ginsenosides were detected was also recorded. One hour after taking the vitamin ginseng zinc capsule, blood was drawn from the rats again, and the blood was tested for any active ingredient in the core material, including vitamins, ginseng composition, zinc sulfate, and pollen, which was recorded as the 1-hour active ingredient content. Four hours after taking the capsule, blood was drawn from the rats again, and the blood was tested for any active ingredient in the core material, including vitamins, ginseng composition, zinc sulfate, and pollen, which was recorded as the 4-hour active ingredient content. The difference in active ingredient content was calculated as 1-hour active ingredient content - 4-hour active ingredient content. The smaller the difference in active ingredient content, the longer the duration of the drug effect, the less likely it is to produce an irritation reaction, and the higher the drug utilization rate.

[0043] 2. Irritation detection The methods of Examples 1-5 and Comparative Examples 1-3 were respectively used to prepare Weishen Zinc Capsules, and 80 male volunteers with an average age of 50-52 years old were recruited and divided into 8 groups. After taking Weishen Zinc Capsules continuously for 1 week, 2 capsules per day, once in the morning and once in the evening, the adverse reactions such as nausea, vomiting, stomach discomfort, constipation, etc. were recorded and rated and scored, with no symptoms such as nausea, vomiting, stomach discomfort, constipation, etc. 10 points → severe nausea, vomiting, stomach discomfort, and constipation 1 point.

[0044] Table 1 Performance test table (“ / ” in the table means that the corresponding embodiment or comparative example did not test the item, so there is no data) From Examples 1-3 and Table 1, it can be seen that after ingestion of the vitamin C and zinc capsules prepared in the present application, the effective ingredients enter the blood in a short time, and the content of the effective ingredients does not change significantly for a long time. At the same time, symptoms such as nausea, vomiting, and constipation are not easy to occur. This shows that the effective ingredients of the prepared vitamin C and zinc capsules can quickly enter the blood circulation, improve the body's absorption efficiency and utilization rate of the effective ingredients, are suitable for middle-aged and elderly people, and are not easy to cause discomfort.

[0045] From Example 1 and Examples 4-5 and Table 1, it can be seen that no polyethylene glycol 2000 is added to the ginseng composition in the core material of Example 4. Compared with Example 1, the detection intake time of the effective ingredients in the blood of the vitamin ginseng zinc capsule prepared in Example 4 is longer than that in Example 1, and the ginsenoside detection time is longer than that in Example 1. This indicates that the pore-forming effect of polyethylene glycol 2000 improves the rapid decomposition and absorption of ginseng powder in the intestine, and improves the extraction rate of nutrients in ginseng, thereby ensuring the absorption efficiency and utilization rate of nutrients in the finished vitamin ginseng zinc capsule, which is suitable for middle-aged and elderly people.

[0046] The dietary fiber of Example 5 is citrus dietary fiber. Compared with Example 1, the content difference of the effective ingredient prepared in Example 5 is greater than that in Example 1, and the score is lower than that in Example 1; this indicates that citrus dietary fiber and white kidney bean dietary fiber can regulate sugar content. An appropriate amount of sugar can not only promote the decomposition of the capsule shell, but also prolong the residence time of the drug effect in the blood. At the same time, it has the advantages of protecting the intestines and improving constipation, so that middle-aged and elderly people with poor intestinal function can take Weishen Zinc Capsules without easily causing discomfort.

[0047] Combining Example 1 and Comparative Examples 1-3 and Table 1, it can be seen that bromelain is not added to the core material of Comparative Example 1. Compared with Example 1, the intake time of the vitamin ginseng zinc capsule prepared in Comparative Example 1 is longer than that in Example 1, the difference in the content of effective ingredients is greater than that in Example 1, and the score is lower than that in Example 1; this indicates that bromelain can increase the content of intestinal protease, further promote the decomposition of proteins in colloids, ginseng compositions and other substances, improve the intestinal absorption rate and utilization rate of nutrients in the vitamin ginseng zinc capsule, and prolong the duration of drug effect.

[0048] Comparative Example 2 did not add dietary fiber. Compared with Example 1, the intake time of the vitamin C and zinc capsules prepared in Comparative Example 2 was longer than that in Example 1, the difference in the content of effective ingredients was greater than that in Example 1, and the score was lower than that in Example 1. This shows that the addition of dietary fiber can not only promote the decomposition of the capsule shell, but also regulate the intestinal digestion and absorption rate of the vitamin C and zinc capsules, promote the circulation of effective ingredients in the blood, and prolong the efficacy time.

[0049] No mixed liquid was added to the film-forming liquid of Comparative Example 3. Compared with Example 1, the intake time of the vitamin C zinc capsules prepared in Comparative Example 3 was longer than that of Example 1, the difference in the content of effective ingredients was greater than that of Example 1, and the score was lower than that of Example 1; this indicated that dietary fiber and oat polypeptides could promote intestinal peristalsis and regulate intestinal function in the elderly, and that oat polypeptides could promote the growth and reproduction of beneficial bacteria in the intestine, increase intestinal flora, and further improve the efficiency of the intestine in decomposing the nutrients in the core material; combined with glutamine, it protected the intestinal mucosal structure, enhanced intestinal cell vitality, promoted the intestinal absorption of water, and increased the intestinal absorption of chlorine and sodium, further promoting the nutrients in the core material of the vitamin C zinc capsules to quickly enter the blood circulation, thereby improving the absorption efficiency and utilization rate of the effective ingredients in the vitamin C zinc capsules in the elderly.

[0050] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. A processing technology of Weishen Zinc Capsules, characterized in that: The steps include: S1, mixing vitamins, ginseng composition, zinc sulfate, pollen, bromelain, and adhesive liquid uniformly to obtain a core material; S2, mixing cellulose acetate solution and dietary fiber at a mass ratio of 100:2-5 to obtain a composite solution; weighing glutamine, oat polypeptide, polysaccharide, and water at a mass ratio of 1:1-3:2-8:90-120 and mixing them evenly to obtain a mixed solution; adding water to the colloid, heating and stirring until it is completely dissolved to obtain a glue solution with a concentration of 0.5-1%; mixing the composite solution, the mixed solution, and the glue solution at a mass ratio of 100:30-50:20-50 and stirring them evenly to obtain a film-forming solution; S3, pouring the film-forming liquid into a mold, drying and molding to obtain a capsule shell; S4, pouring the core material into the capsule shell to obtain the finished product.

2. The processing technology of a vitamin C zinc capsule according to claim 1 is characterized in that: The core material comprises the following raw materials in parts by weight: 10-15 parts of vitamins, 40-60 parts of ginseng composition, 0.5-1 part of zinc sulfate, 10-15 parts of pollen, 0.5-1 part of bromelain, and 20-40 parts of adhesive; the adhesive is composed of starch liquid and fucoidan liquid in a mass ratio of 1:0.5-1.

3. The processing technology of a vitamin C zinc capsule according to claim 1 is characterized in that: The vitamins are composed of vitamin E and vitamin C in a mass ratio of 1:0.2-0.

5.

4. The processing technology of a vitamin ginseng zinc capsule according to claim 1 is characterized in that: The ginseng composition is prepared from ginseng powder and polyethylene glycol 2000 in a mass ratio of 1:0.1-0.

2.

5. The processing technology of a vitamin C zinc capsule according to claim 1 is characterized in that: The pollen is pine pollen.

6. The processing technology of a vitamin ginseng zinc capsule according to claim 1 is characterized in that: The dietary fiber consists of citrus dietary fiber and white kidney bean dietary fiber in a mass ratio of 1:0.2-0.

5.

7. The processing technology of a vitamin ginseng zinc capsule according to claim 1 is characterized in that: The average particle size of the dietary fiber is 20-80 μm.

8. The processing technology of a vitamin C zinc capsule according to claim 1 is characterized in that: The glutamine is L-glutamine.

9. The processing technology of a vitamin ginseng zinc capsule according to claim 1, characterized in that: The polysaccharide consists of maltose and fucoidan in a mass ratio of 1:0.2-0.

5.

10. The processing technology of the vitamin C and zinc capsule according to claim 1 is characterized in that: The colloid is composed of gum arabic and linseed gum in a mass ratio of 1:0.5-1.

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