Traditional Chinese medicine composition for treating cough of pets and preparation method of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for treating pet cough and a preparation method thereof, and the traditional Chinese medicine composition comprises the following components in parts by weight: 8-16 parts of ephedra, 5-12 parts of almond, 5-8 parts of houttuynia cordata, 2-5 parts of licorice extract, 2-5 parts of platycodon grandiflorum extract, 3-5 parts of perilla leaf, 2-4 parts of herba siegesbeckiae, 0.5-1.5 parts of almond oil, 0.5-1.5 parts of borneol, 1-2 parts of loratadine and 3-6 parts of mannitol. According to the traditional Chinese medicine composition, through the synergistic effect of various traditional Chinese medicine components and western medicine components, the comprehensive curative effect can be achieved. Traditional Chinese medicine components such as ephedra, almond and houttuynia cordata can effectively relieve cough, clear lung and reduce phlegm; western medicine components such as loratadine and a licorice extract have anti-allergic and anti-inflammatory effects and help to relieve cough caused by allergy or infection.

Description

Technical Field

[0001] The invention relates to the technical field of pet medicines, and in particular to a traditional Chinese medicine composition for treating pet cough and a preparation method thereof. Background Art

[0002] With the rapid development of the pet breeding industry, pet health issues have gradually attracted the attention of more and more pet owners. Pet cough is a common clinical symptom, usually caused by respiratory infections, allergic reactions, environmental factors, etc. The current pet cough treatment drugs on the market are mainly Western medicines, but many Western medicines have certain side effects and are prone to drug resistance after use. At the same time, traditional Chinese medicine has significant therapeutic effects on pet coughs with fewer side effects. However, most of the existing Chinese medicine preparations are immediate-release drugs, and the drugs are released too quickly in the body, making it difficult to sustain the therapeutic effect. Therefore, a more efficient, continuous and safe treatment method is urgently needed. Summary of the invention

[0003] Purpose of the invention: The purpose of the present invention is to provide a Chinese medicine composition for treating pet cough and a preparation method thereof. The Chinese medicine composition of the present invention can exert a comprehensive therapeutic effect through the synergistic effect of multiple Chinese medicine ingredients and Western medicine ingredients. Traditional Chinese medicine ingredients such as ephedra, almond, houttuynia cordata, etc. can effectively relieve cough, clear the lungs and reduce phlegm; Western medicine ingredients such as loratadine and licorice extract have anti-allergic and anti-inflammatory effects, helping to relieve cough caused by allergies or infections.

[0004] Technical solution:

[0005] A traditional Chinese medicine composition for treating pet cough comprises, by weight, 8-16 parts of ephedra, 5-12 parts of almond, 5-8 parts of houttuynia cordata, 2-5 parts of licorice extract, 2-5 parts of platycodon extract, 3-5 parts of perilla leaves, 2-4 parts of siegetable herb, 0.5-1.5 parts of almond oil, 0.5-1.5 parts of borneol, 1-2 parts of loratadine, 3-6 parts of mannitol, 2-5 parts of honey, 1-3 parts of emulsifier and 1-3 parts of ethanol.

[0006] Furthermore, the invention comprises, by weight, 10-15 parts of ephedra, 8-12 parts of almond, 5-8 parts of houttuynia cordata, 3-5 parts of licorice extract, 2-5 parts of platycodon extract, 3-5 parts of perilla leaves, 2-4 parts of siegetable herb, 0.5-1.5 parts of almond oil, 0.5-1 part of borneol, 1-2 parts of loratadine, 4-6 parts of mannitol, 2-4 parts of honey, 1-2 parts of emulsifier and 1-2 parts of ethanol.

[0007] Furthermore, the emulsifier is triglyceride or laurin.

[0008] The above ingredients are described below, wherein:

[0009] The main function of ephedra is to relieve cough, dyspnea and bronchitis symptoms caused by cold and dampness, especially it has a significant effect on relieving the wheezing symptoms of pet cough.

[0010] Almonds in this remedy help relieve dry coughs, clear mucus from the airways, and relieve lung discomfort caused by cold pathogens.

[0011] Houttuynia cordata can relieve coughs caused by infection or inflammation, and help clear airway congestion and secretions caused by viral infections.

[0012] Licorice extract helps relieve coughs, reduce respiratory inflammation, enhance immunity, and plays an important role in regulating the efficacy of drugs.

[0013] Platycodon grandiflorum works by relieving cough symptoms, clearing mucus from the airways, and helping to relieve the discomfort caused by coughing up phlegm.

[0014] Perilla leaves play a role in relieving coughs caused by pathogenic cold, reducing airway discomfort and promoting smooth airflow.

[0015] Siegesbeckia helps clear phlegm from the respiratory tract and relieves coughs caused by allergies or infections.

[0016] Almond oil provides lubrication for the medication, reduces dryness and irritation in the respiratory tract, and helps relieve coughs.

[0017] Borneol helps soothe the respiratory tract and relieve cough symptoms, especially for coughs caused by inflammation or allergies.

[0018] Loratadine can relieve allergic cough and inflammation of the respiratory tract, reducing throat discomfort and itching caused by allergies.

[0019] Mannitol can help moisten the respiratory tract and relieve coughs caused by dryness or phlegm.

[0020] Honey: Honey helps lubricate the airways, relieve coughs and throat discomfort, and is especially effective in treating dry coughs and allergic coughs.

[0021] Emulsifiers help to evenly mix fat-soluble ingredients (such as almond oil and borneol) with water-soluble ingredients, improving the stability and absorption of drugs.

[0022] Ethanol helps dissolve and extract the active ingredients in Chinese herbal medicines, and also serves as a solvent in preparations to promote drug absorption.

[0023] The present invention also discloses a method for preparing a Chinese medicine composition for treating pet cough, comprising the following steps:

[0024] S1. Extraction of medicinal materials: Mix and grind ephedra, almond, houttuynia cordata, platycodon grandiflorum extract, perilla leaf, and siegetable herb, sieve, perform reflux extraction with ethanol solution, and collect the extract; filter and concentrate the extract, and dry it to obtain the Chinese medicine extract powder;

[0025] S2. Drug mixing: add licorice extract, loratadine, honey, emulsifier and mannitol to the Chinese medicine extract powder in proportion, stir evenly to form a drug premix; add an appropriate amount of ethanol, stir evenly to ensure that all ingredients are dissolved;

[0026] S3, granulation: add the drug premix into a wet granulator, add mannitol and PVP-K30 ethanol solution, stir evenly to form a soft material, and then granulate it through a swing granulator to obtain Chinese medicine granules;

[0027] S4, coating preparation: using microcrystalline cellulose, cellulose acetate, and polyethylene glycol 400 to prepare a sustained-release coating slurry, spraying it on the surface of the traditional Chinese medicine particles to form a sustained-release coating layer; using an ethanol solution of ambroxol hydrochloride, loratadine, borneol, and mannitol to prepare a quick-release coating slurry, spraying it on the surface of the sustained-release particles to form a quick-release coating layer;

[0028] S5. Final product: Dry the coated particles to obtain composite sustained-release drug particles.

[0029] Further, in step S1, reflux extraction is performed with 60%-70% ethanol solution, and the extraction is performed twice, each time for 2 hours.

[0030] Further, in step S1, the extract is filtered and concentrated to a relative density of 1.18-1.20.

[0031] Furthermore, in step S5, the moisture content of the particles is controlled at 2-3%.

[0032] Beneficial effects:

[0033] 1. The Chinese medicine composition of the present invention can exert a comprehensive therapeutic effect through the synergistic effect of multiple Chinese medicine ingredients and Western medicine ingredients. Traditional Chinese medicine ingredients such as ephedra, almond, houttuynia cordata, etc. can effectively relieve cough, clear the lungs and reduce phlegm; Western medicine ingredients such as loratadine and licorice extract have anti-allergic and anti-inflammatory effects, helping to relieve cough caused by allergies or infections.

[0034] 2. The present invention adopts sustained-release and quick-release coating technology to enable the drug to be continuously released in the body, ensuring the high efficiency and stability of the drug and effectively improving the therapeutic effect. The sustained-release coating layer can prolong the drug's action time in the body, while the quick-release coating layer can ensure that the drug takes effect quickly in the early stage, thereby achieving an ideal therapeutic effect.

[0035] 3. The present invention adopts a composite formula of natural Chinese herbal medicine and Western medicine ingredients, the source of the drug ingredients is reliable, the side effects are small, and it is suitable for long-term use by pets. In particular, the Chinese herbal medicine ingredients have good biocompatibility and low toxic side effects, which can effectively avoid the side effects and drug resistance problems that may be caused by long-term use of Western medicine. DETAILED DESCRIPTION

[0036] In order to make the technical solution of the present invention clearer, the present invention is further described in detail below in conjunction with specific embodiments.

[0037] Example 1

[0038] A traditional Chinese medicine composition for treating pet cough comprises, by weight, 12 parts of ephedra, 10 parts of almond, 6 parts of houttuynia cordata, 4 parts of licorice extract, 3 parts of platycodon extract, 4 parts of perilla leaves, 3 parts of siegetable herb, 1 part of almond oil, 0.8 parts of borneol, 1.5 parts of loratadine, 5 parts of mannitol, 3 parts of honey, 2 parts of emulsifier and 2 parts of ethanol.

[0039] Example 2

[0040] A traditional Chinese medicine composition for treating pet cough comprises, by weight, 12 parts of ephedra, 10 parts of almond, 6 parts of houttuynia cordata, 4 parts of licorice extract, 3 parts of platycodon extract, 4 parts of perilla leaves, 3 parts of siegetable herb, 1 part of almond oil, 0.8 parts of borneol, 1.5 parts of loratadine, 5 parts of mannitol, 3 parts of honey, 2 parts of emulsifier and 2 parts of ethanol.

[0041] Example 3

[0042] A traditional Chinese medicine composition for treating pet cough comprises, by weight, 12 parts of ephedra, 10 parts of almond, 6 parts of houttuynia cordata, 4 parts of licorice extract, 3 parts of platycodon extract, 4 parts of perilla leaves, 3 parts of siegetable herb, 1 part of almond oil, 0.8 parts of borneol, 1.5 parts of loratadine, 5 parts of mannitol, 3 parts of honey, 2 parts of emulsifier and 2 parts of ethanol.

[0043] Comparative Example 1

[0044] A Chinese medicine composition for treating pet cough, the main ingredients of which include ephedra, almond, licorice and loratadine. The specific formula is: ephedra, almond, licorice, loratadine. The preparation method of this technology is relatively simple, does not contain other Chinese medicine ingredients, and does not use emulsifiers or sustained-release or quick-release coating technology.

[0045] Comparative Example 2

[0046] A compound Chinese medicine composition for treating pet cough, the main ingredients of which include ephedra, almond, houttuynia cordata, platycodon, honey, loratadine and licorice, etc., and emulsifier and mannitol are added to improve the stability and bioavailability of the drug.

[0047] The above embodiments and comparative examples were tested, and the pet store cough pet treatment effect comparison test was performed:

[0048] Purpose of the experiment: This experiment aims to evaluate the efficacy of five different formulations of Example 1, Example 2, Example 3 and Comparative Example 1 and Comparative Example 2, especially in terms of antitussive, anti-inflammatory, expectorant, lung moistening, anti-allergic effects and duration of efficacy.

[0049] Test subjects: Pets with coughing symptoms in pet stores, including dogs and cats, were selected. Coughing symptoms were dry cough, wet cough, continuous cough or intermittent cough, and lasted for more than one week.

[0050] Experimental design: Experimental grouping: The pets participating in the experiment were randomly divided into 5 groups, with 20 pets in each group. Each group contained a different drug formulation to ensure that the basic conditions such as gender, age, and weight of each group of pets were similar.

[0051] Dosage method: Each pet is given the drug once a day according to body weight for 7 consecutive days. The drug is administered in the form of oral solution, granules or ointment, depending on the pet's acceptance.

[0052] Trial period: The total trial period is 14 days, the first 7 days are the treatment period, and the last 7 days are the observation period.

[0053] 4. Test steps:

[0054] Step 1: Preliminary assessment Observe the coughing symptoms of the pet, record the coughing type, frequency, duration and other indicators of the pet, and score the symptoms (1-5 points, 1 is the lightest and 5 is the heaviest). In addition, record the basic information of the pet such as age, weight, gender, etc. to ensure the reliability of the experimental data.

[0055] Step 2: Drug treatment According to the grouping, give each group of pets oral medication of the corresponding formula every day to ensure that each pet receives treatment according to the standard dose. During the treatment, observe whether the pet has side effects such as vomiting, loss of appetite, etc. If there is any adverse reaction, stop using it immediately and deal with it.

[0056] Step 3: Efficacy observation At the end of the 7th day of treatment, record the improvement of cough symptoms in each group of pets and compare the symptom changes before and after treatment. The evaluation includes:

[0057] Antitussive effect: changes in cough frequency and intensity;

[0058] Anti-inflammatory effect: whether it reduces inflammation of the throat and trachea caused by coughing;

[0059] Expectorant effect: changes in sputum, such as viscosity and secretion volume;

[0060] Lung moistening effect: pet's breathing condition, whether symptoms of wheezing or breathing difficulties are relieved;

[0061] Anti-allergic effect: whether allergic reactions are alleviated;

[0062] Duration of drug efficacy: How long the drug lasts to work, to observe whether there are recurring attacks after treatment.

[0063] Step 4: Experimental summary and analysis On the 14th day, a comprehensive evaluation was conducted, the treatment effects were recorded, and the efficacy comparison data of each formula were collated and analyzed to obtain the advantages and disadvantages of each formula.

[0064]

[0065] According to the experimental results, the formulas of Examples 1, 2, and 3 performed well in treating pet cough, especially in antitussive, anti-inflammatory, lung moistening, anti-allergic and drug effect persistence. In contrast, the performance of Comparative Examples 1 and 2 in various therapeutic effects was relatively weak, especially in expectoration and anti-allergic effects, and failed to achieve the desired effect. Overall, Examples 1, 2, and 3 are preferred formulas for treating pet cough.

[0066] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the patent of the present invention. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A Chinese medicine composition for treating pet cough, characterized in that: The invention comprises, by weight, 8-16 parts of ephedra, 5-12 parts of almond, 5-8 parts of houttuynia cordata, 2-5 parts of licorice extract, 2-5 parts of platycodon extract, 3-5 parts of perilla leaves, 2-4 parts of siegetable herb, 0.5-1.5 parts of almond oil, 0.5-1.5 parts of borneol, 1-2 parts of loratadine, 3-6 parts of mannitol, 2-5 parts of honey, 1-3 parts of emulsifier and 1-3 parts of ethanol.

2. A Chinese medicine composition for treating pet cough according to claim 1, characterized in that: The invention comprises, by weight, 10-15 parts of ephedra, 8-12 parts of almond, 5-8 parts of houttuynia cordata, 3-5 parts of licorice extract, 2-5 parts of platycodon grandiflorum extract, 3-5 parts of perilla leaves, 2-4 parts of siegetable herb, 0.5-1.5 parts of almond oil, 0.5-1 parts of borneol, 1-2 parts of loratadine, 4-6 parts of mannitol, 2-4 parts of honey, 1-2 parts of emulsifier and 1-2 parts of ethanol.

3. A Chinese medicine composition for treating pet cough according to claim 1, characterized in that: The emulsifier is triglyceride or laurin.

4. A method for preparing a Chinese medicine composition for treating pet cough according to any one of claims 1 to 3, characterized in that: The following steps are involved: S1. Extraction of medicinal materials: Mix and grind ephedra, almond, houttuynia cordata, platycodon grandiflorum extract, perilla leaf, and siegetable herb, sieve, perform reflux extraction with ethanol solution, and collect the extract; filter and concentrate the extract, and dry it to obtain the Chinese medicine extract powder; S2. Drug mixing: add licorice extract, loratadine, honey, emulsifier and mannitol to the Chinese medicine extract powder in proportion, stir evenly to form a drug premix; add an appropriate amount of ethanol, stir evenly to ensure that all ingredients are dissolved; S3, granulation: add the drug premix into a wet granulator, add mannitol and PVP-K30 ethanol solution, stir evenly to form a soft material, and then granulate it through a swing granulator to obtain Chinese medicine granules; S4, coating preparation: using microcrystalline cellulose, cellulose acetate, and polyethylene glycol 400 to prepare a sustained-release coating slurry, spraying it on the surface of the traditional Chinese medicine particles to form a sustained-release coating layer; using an ethanol solution of ambroxol hydrochloride, loratadine, borneol, and mannitol to prepare a quick-release coating slurry, spraying it on the surface of the sustained-release particles to form a quick-release coating layer; S5. Final product: Dry the coated particles to obtain composite sustained-release drug particles.

5. The method for preparing a Chinese medicine composition for treating pet cough according to claim 4, characterized in that: In step S1, reflux extraction is performed with 60%-70% ethanol solution, and the extraction is performed twice, each time for 2 hours.

6. The method for preparing a Chinese medicine composition for treating pet cough according to claim 4, characterized in that: In step S1, the extract is filtered and concentrated to a relative density of 1.18-1.

20.

7. The method for preparing a Chinese medicine composition for treating pet cough according to claim 4, characterized in that: In step S5, the moisture content of the particles is controlled at 2-3%.

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