Formula and application of medicine for treating intestinal cancer

Abstract

The invention discloses a formula and application of a medicine for treating intestinal cancer. The formula is prepared from the following raw materials: roasted rhizoma atractylodis macrocephalae, rhizoma dioscoreae, fructus aurantii, fructus alpiniae oxyphyllae, herba scutellariae barbatae and herba lobeliae chinensis. According to the formula of the medicine for treating the intestinal cancer, through scientific material selection and reasonable matching, all the components can coordinate and promote one another to achieve the synergistic interaction effect, and in the formula, one is the effects of tonifying the spleen, strengthening the body resistance and nourishing the acquired body; the traditional Chinese medicine has the effects of soothing liver and regulating qi, dispersing blood stasis and eliminating diseases, has the curative effect of reducing colorectal cancer liver metastasis, can improve the living quality of patients, and can be used by the patients for a long time.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a formula and application of a drug for treating colorectal cancer. Background Art

[0002] The metastasis of colorectal cancer occurs under the interaction of "deficiency of body fluid" and "poisonous evil". "Imbalance of yin and yang" is the key link of colorectal cancer metastasis. In the early stage of cancer, the main manifestation is the invasion and spread around the primary lesion. In the middle and late stages, the cancer spreads along the collaterals and meridians, forming a local metastasis microenvironment with metabolic disorders, hypoxia, and accumulation of inflammatory factors. Once the steady-state imbalance of the microenvironment will lead to imbalance of yin and yang, the cancer cells will take root in the distant places along the blood flow to form distant metastatic lesions. Based on his many years of clinical experience, Chief Researcher Professor Park Byung-gyu emphasizes the dominant position of the treatment principle of "strengthening the body's resistance, removing toxins, and harmonizing yin and yang" in the prevention and treatment of malignant tumors. He focuses on strengthening the body's resistance and nurturing the foundation, protecting the spleen and stomach, taking into account clearing away heat and detoxifying, removing dampness and resolving phlegm, and removing stagnation and dispersing blood stasis, treating the disease based on syndrome differentiation, tonifying the middle and replenishing qi, regulating qi, stabilizing the intestinal microenvironment and the yin and yang balance of the human body, thereby preventing the formation of a metastatic microenvironment. He believes that whether the metastasis can be effectively controlled is the key to the success of colorectal cancer treatment, and thus formed a clinically proven prescription for strengthening the body's resistance and removing toxins, and this prescription is modified by adding and subtracting on its basis. Summary of the invention

[0003] In view of the defects of the prior art, the purpose of the present invention is to provide a formulation and application of a drug for treating colorectal cancer, so as to solve the problems raised in the above background technology.

[0004] The present invention solves the technical problem by adopting the following technical solution:

[0005] The invention provides a formula of a medicine for treating intestinal cancer. The formula is composed of the following raw materials: stir-fried atractylodes macrocephala, yam, fructus aurantii, alpinia oxyphylla, scutellaria barbata and scutellaria baicalensis.

[0006] Preferably, the formula is composed of the following raw materials by weight: 10-20g of stir-fried Atractylodes macrocephala, 12-18g of yam, 5-15g of Citrus aurantium, 13-27g of Alpinia oxyphylla, 16-24g of Scutellaria barbata and 15-25g of Scutellaria baicalensis.

[0007] Preferably, the formula is composed of the following raw materials by weight: 10g of stir-fried Atractylodes macrocephala, 12g of yam, 5g of Citrus aurantium, 13g of Alpinia oxyphylla, 16g of Scutellaria barbata and 15g of Scutellaria baicalensis.

[0008] Preferably, the formula is composed of the following raw materials by weight: 20g stir-fried Atractylodes macrocephala, 18g yam, 15g fructus aurantii, 27g Alpinia oxyphylla, 24g Scutellaria barbata and 25g Scutellaria baicalensis.

[0009] Preferably, the formula is composed of the following raw materials by weight: 15g stir-fried Atractylodes macrocephala, 15g yam, 10g Citrus aurantium, 20g Alpinia oxyphylla, 20g Scutellaria barbata and 20g Scutellaria baicalensis.

[0010] Stir-fried Atractylodes macrocephala replenishes Qi, strengthens the spleen and dries dampness; Chinese yam replenishes Qi, strengthens the spleen and nourishes Yin; Citrus aurantium breaks up Qi, removes phlegm and eliminates accumulation; Alpinia oxyphylla warms the spleen, stops diarrhea, controls salivation, warms the kidneys, reduces urine and consolidates semen; Scutellaria barbata cools blood and detoxifies, disperses blood stasis and relieves pain, reduces swelling, and clears heat and removes dampness; Scutellaria barbata is sweet and mild in nature, and clears heat and detoxifies.

[0011] The present invention also provides a method for preparing a drug for treating colorectal cancer, comprising the following steps:

[0012] Step 1, weigh the above raw materials, add 8-20 times the total weight of the raw materials to soak them, then extract them 2-4 times, each time for 1-3 hours, and concentrate under reduced pressure to obtain an extract;

[0013] Step 2: Take the extract of step 1 and add pharmaceutically acceptable excipients to prepare Chinese medicine granules.

[0014] Preferably, the extract is water, and the auxiliary material is any one of corn starch, dextrin, stearic acid, magnesium stearate and stevioside.

[0015] Preferably, in step 1, the raw material soaking time is 0.5-1h, and the soaking temperature is 30-40°C.

[0016] The present invention also provides an application of a formula for treating intestinal cancer in preparing a drug for treating intestinal cancer.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] The present invention provides a formula for treating colorectal cancer. Through scientific material selection and reasonable proportioning, the components can coordinate and promote each other to achieve a synergistic effect. The formula can strengthen the spleen and nourish the body, and soothe the liver and regulate qi, resolve blood stasis and relieve symptoms. It has the efficacy of reducing liver metastasis of colorectal cancer, can improve the quality of life of patients, and can be used by patients for a long time. DETAILED DESCRIPTION

[0019] The following is a clear and complete description of the technical solutions in the embodiments of the present invention in conjunction with specific embodiments. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0020] Example 1.

[0021] The present embodiment provides a formulation for treating colorectal cancer, the formulation consisting of the following ingredients: stir-fried Atractylodes macrocephala, Chinese yam, Fructus Aurantii Immaturus, Alpinia oxyphylla, Scutellaria barbata and Scutellaria baicalensis.

[0022] The formula of this embodiment is composed of the following raw materials by weight: 10g of stir-fried Atractylodes macrocephala, 12g of yam, 5g of Fructus Aurantii Immaturus, 13g of Alpinia oxyphylla, 16g of Scutellaria barbata and 15g of Scutellaria baicalensis.

[0023] A method for preparing a drug for treating colorectal cancer in this embodiment comprises the following steps:

[0024] Step 1, weigh the above raw materials, add 8 times the total weight of the extracting solution to soak them first, then extract them twice, each time for 1 hour, combine the two extracts, and concentrate to obtain an extract;

[0025] Step 2: Take the extract of step 1, add pharmaceutically acceptable excipients, mix evenly, granulate, dry, and prepare into Chinese medicine granules.

[0026] The extracting liquid in this embodiment is water, and the auxiliary material is corn starch.

[0027] In step 1 of this embodiment, the raw material soaking time is 0.5h and the soaking temperature is 30°C.

[0028] Example 2.

[0029] The present embodiment provides a formulation for treating colorectal cancer, the formulation consisting of the following ingredients: stir-fried Atractylodes macrocephala, Chinese yam, Fructus Aurantii Immaturus, Alpinia oxyphylla, Scutellaria barbata and Scutellaria baicalensis.

[0030] The formula of this embodiment is composed of the following raw materials by weight: 20g of stir-fried Atractylodes macrocephala, 18g of yam, 15g of Citrus aurantium, 27g of Alpinia oxyphylla, 24g of Scutellaria barbata and 25g of Scutellaria baicalensis.

[0031] A method for preparing a drug for treating colorectal cancer in this embodiment comprises the following steps:

[0032] Step 1, weigh the above raw materials, add 20 times the total weight of the extracting solution to soak them first, then extract them 4 times, each time for 3 hours, combine the 4 extracts, and concentrate under reduced pressure to obtain an extract;

[0033] Step 2: Take the extract of step 1, add pharmaceutically acceptable excipients, mix evenly, granulate, dry, and prepare into Chinese medicine granules.

[0034] The extracting liquid in this embodiment is water, and the auxiliary material is dextrin.

[0035] In step 1 of this embodiment, the raw material soaking time is 1 hour and the soaking temperature is 40°C.

[0036] Example 3.

[0037] The present embodiment provides a formulation for treating colorectal cancer, the formulation consisting of the following ingredients: stir-fried Atractylodes macrocephala, Chinese yam, Fructus Aurantii Immaturus, Alpinia oxyphylla, Scutellaria barbata and Scutellaria baicalensis.

[0038] The formula of this embodiment is composed of the following raw materials by weight: 15g of stir-fried Atractylodes macrocephala, 15g of yam, 10g of Fructus Aurantii Immaturus, 20g of Alpinia oxyphylla, 20g of Scutellaria barbata and 20g of Scutellaria baicalensis.

[0039] A method for preparing a drug for treating colorectal cancer in this embodiment comprises the following steps:

[0040] Step 1, weigh the above raw materials, add 14 times the total weight of the extracting solution to soak them first, then extract them 3 times, each time for 2 hours, combine the 3 extracts, and concentrate under reduced pressure to obtain an extract;

[0041] Step 2: Take the extract of step 1, add pharmaceutically acceptable excipients, mix evenly, granulate, dry, and prepare into Chinese medicine granules.

[0042] The extract in this embodiment is water, and the auxiliary material is stevioside.

[0043] In step 1 of this embodiment, the raw material soaking time is 0.7h and the soaking temperature is 35°C.

[0044] The implementation standards in the above embodiment 3 are as follows:

[0045] Alpinia oxyphylla formula granules, each 1g granules is equivalent to 3.5g of decoction pieces, implementation standard: "Chinese Pharmacopoeia" 2020 edition

[0046] Citrus aurantium formula granules, each 1g granules is equivalent to 3.5g of decoction pieces, implementation standard: "Chinese Pharmacopoeia" 2020 edition

[0047] Stir-fried Atractylodes macrocephala granules, each 1g granule is equivalent to 1.2g of decoction pieces, implementation standard: "Chinese Pharmacopoeia" 2020 edition

[0048] Yam formula granules, each 1g granules is equivalent to 4g of decoction pieces, implementation standard: "Chinese Pharmacopoeia" 2020 edition

[0049] Scutellaria barbata formula granules, each 1g granules is equivalent to 4g of decoction pieces, implementation standard: "Chinese Pharmacopoeia" 2020 edition

[0050] Each 1g of Lobelia formula granules is equivalent to 4g of decoction pieces. Implementation standard: "Chinese Pharmacopoeia" 2020 edition

[0051] The above granules are mixed after conversion according to the prescription.

[0052] Experimental study: The drugs for treating colorectal cancer prepared in any of the above Examples 1-3 were prepared into decoctions and subjected to animal experiments.

[0053] Example 4

[0054] The typical embodiment 3 is used as an example for description, and the effects of other embodiments are equivalent, as follows:

[0055] HCT116 nude mouse models were constructed and divided into the following groups: ① blank control group (KB) ② HCT116-Control model group ③ HCT116+FZJD group. The LA levels of patients were monitored weekly, and the liver and subcutaneous tumor tissues of mice were collected after 14 days. The results showed that FZJD could reduce the LA level of mice (P < 0.05) and inhibit the progression of transplanted tumors and liver metastasis in mice.

[0056] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the present invention can be implemented in other specific forms without departing from the spirit or essential features of the present invention. Therefore, the embodiments should be considered exemplary and non-restrictive in all respects, and the scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims be included in the present invention.

[0057] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A formulation for treating colorectal cancer, characterized in that: The formula is composed of the following raw materials: stir-fried Atractylodes macrocephala, Chinese yam, Citrus aurantium, Alpinia oxyphylla, Scutellaria barbata and Scutellaria baicalensis.

2. A formulation for treating colorectal cancer according to claim 1, characterized in that: The formula is composed of the following raw materials by weight: 10-20g of stir-fried Atractylodes macrocephala, 12-18g of Chinese yam, 5-15g of Citrus aurantium, 13-27g of Alpinia oxyphylla, 16-24g of Scutellaria barbata and 15-25g of Scutellaria baicalensis.

3. A formulation for treating colorectal cancer according to claim 2, characterized in that: The formula is composed of the following raw materials by weight: 10g of stir-fried Atractylodes macrocephala, 12g of Chinese yam, 5g of Citrus aurantium, 13g of Alpinia oxyphylla, 16g of Scutellaria barbata and 15g of Scutellaria baicalensis.

4. A formulation for treating colorectal cancer according to claim 1, characterized in that: The formula is composed of the following raw materials by weight: 20g of stir-fried Atractylodes macrocephala, 18g of Chinese yam, 15g of Citrus aurantium, 27g of Alpinia oxyphylla, 24g of Scutellaria barbata and 25g of Scutellaria baicalensis.

5. A formulation for treating colorectal cancer according to claim 2, characterized in that: The formula is composed of the following raw materials by weight: 15g of stir-fried Atractylodes macrocephala, 15g of Chinese yam, 10g of Citrus aurantium, 20g of Alpinia oxyphylla, 20g of Scutellaria barbata and 20g of Scutellaria baicalensis.

6. The method for preparing a drug for treating colorectal cancer according to any one of claims 1 to 5, characterized in that: The following steps are involved: Step 1, weigh the above raw materials, add 8-20 times the total weight of the raw materials to soak them, then extract them 2-4 times, each time for 1-3 hours, and concentrate under reduced pressure to obtain an extract; Step 2: Take the extract of step 1 and add pharmaceutically acceptable excipients to prepare Chinese medicine granules.

7. A method for preparing a drug for treating colorectal cancer according to claim 6, characterized in that: The extract is water, and the auxiliary material is any one of corn starch, dextrin, stearic acid, magnesium stearate and stevioside.

8. A method for preparing a drug for treating colorectal cancer according to claim 6, characterized in that: In the step 1, the raw material soaking time is 0.5-1h, and the soaking temperature is 30-40°C.

9. Use of the formula for treating colorectal cancer according to any one of claims 1 to 8 in the preparation of a drug for treating colorectal cancer.