Analyzer
By designing the position of the outer ring and inner ring reagent working positions on the reaction plate of the analyzer, the complex problems of component motion trajectory interference and maintenance in traditional analyzers are solved, and higher operational convenience and equipment stability are achieved.
Patent Information
- Application Number
- CN202510124386.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-26
- Publication Date
- 2025-03-07
AI Technical Summary
Because the working timing of the inner and outer ring reaction disks of traditional analyzers is completely consistent, the working positions of reagents and samples are too concentrated, causing interference in the motion trajectory between components, reducing operational independence, and complex maintenance, which increases costs.
An analyzer is designed, and the reagent working positions of the outer ring and inner ring of the reaction disk are relatively far away, almost on both sides of the reaction disk, which avoids overcrowding of the component layout and improves the convenience of operation and the stability of the equipment.
Through the distributed working position layout, mutual interference between operations is avoided, the overall stability and maintenance convenience of the equipment are improved, and maintenance costs and operating error risks are reduced.
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Figure CN119574898A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the field of biomedical technology, in particular to an analyzer. Background Art
[0002] Analyzers can efficiently detect the concentration of various components in samples by utilizing the changes in the optical properties of substances during chemical reactions. As medical needs continue to grow, the performance requirements for analyzers are also increasing, especially in terms of test speed, accuracy, and automation. Therefore, many manufacturers are committed to developing high-speed fully automatic analyzers to meet the needs of clinical laboratories and research institutions.
[0003] Most of the high-speed analyzers currently available on the market use a dual measurement system solution, that is, two measurement systems share a reaction disk. In order to complete a series of operations such as sample filling, reagent addition, solution stirring, data collection, and automatic cleaning of the reaction container, these devices need to continuously rotate the reaction disk and configure multiple components around it, such as sample dispensing module, reagent dispensing module, stirring and mixing module, photoelectric detection module, and automatic cleaning module. Although this design improves the automation of the test to a certain extent, it also has some significant defects.
[0004] However, the traditional analyzer has the same working sequence of the inner and outer reaction disks, which leads to the over-centralization of the reagent and sample adding positions, causing interference in the motion trajectories between components, reducing the independence of operation, and when a reagent dispensing subsystem fails or requires maintenance, the entire device may not work properly, affecting the test efficiency. In addition, the traditional analyzer has an overly crowded component layout, making cleaning and maintenance operations more complicated and difficult, increasing the use and maintenance costs of the equipment.
[0005] BACKGROUND OF THE INVENTION The above information disclosed is only for understanding the background of the inventive concept and may contain information that does not constitute the prior art. Summary of the invention
[0006] Based on this, it is necessary to provide an analyzer to address the above problems.
[0007] The present application provides an analyzer, comprising:
[0008] frame;
[0009] A reaction disk, arranged on the frame and comprising an inner ring of the reaction disk loaded with reaction cups and an outer ring of the reaction disk;
[0010] The outer ring of the reaction disk has an outer ring photoelectric collection workstation, an outer ring reagent adding workstation No. 1, an outer ring sample adding workstation, an outer ring sample stirring and mixing workstation, an outer ring reagent adding workstation No. 2, an outer ring reagent stirring and mixing workstation and an outer ring reaction cup multi-stage cleaning workstation on the rotation track of the outer ring;
[0011] The rotation track of the inner circle of the reaction disk is provided with an inner circle photoelectric collection work station, an inner circle reagent adding work station No. 1, an inner circle sample adding work station, an inner circle sample stirring and mixing work station, an inner circle reagent adding work station No. 2, an inner circle reagent stirring and mixing work station and an inner circle reaction cup multi-stage cleaning work station;
[0012] A first reagent needle assembly, which is disposed on the frame and can move relative to the frame, and is used to transfer the reagent to the reaction cups at the outer ring reagent adding work position No. 1 and the outer ring reagent adding work position No. 2;
[0013] A second reagent needle assembly, which is disposed on the frame and can move relative to the frame, and is used to transfer the reagent to the reaction cups at the inner circle reagent adding work position No. 1 and the inner circle reagent adding work position No. 2;
[0014] Among them, the angle between the line connecting the outer ring plus reagent No. 1 working position and the center of the reaction disk and the line connecting the inner ring plus reagent No. 1 working position and the center of the reaction disk is greater than 90°; the angle between the line connecting the outer ring plus reagent No. 2 working position and the center of the reaction disk and the line connecting the inner ring plus reagent No. 2 working position and the center of the reaction disk is greater than 90°; the first reagent needle assembly and the second reagent needle assembly are located on both sides of the reaction disk.
[0015] The above analyzer can at least achieve the following beneficial effects: the angle between the line connecting the outer ring reagent No. 1 workstation and the center of the reaction disk and the line connecting the inner ring reagent No. 1 workstation and the center of the reaction disk is greater than 90°, that is, the positions of the outer ring reagent No. 1 workstation and the inner ring reagent No. 1 workstation are far away and almost located on both sides of the reaction disk; the angle between the line connecting the outer ring reagent No. 2 workstation and the center of the reaction disk and the line connecting the inner ring reagent No. 2 workstation and the center of the reaction disk is greater than 90°, that is, the positions of the outer ring reagent No. 2 workstation and the inner ring reagent No. 2 workstation are far away and almost located on both sides of the reaction disk, so the corresponding first reagent needle assembly and the second reagent needle assembly can also be arranged on both sides of the reaction disk, which can avoid the component layout from being too crowded, not only improving the convenience of operation, but also reducing the risk of operational errors caused by narrow space. The dispersed workstation layout effectively avoids mutual interference between different operations, ensuring that operations such as sample filling, reagent addition and photoelectric detection can be performed independently, improving the overall stability of the equipment. Reasonable layout makes cleaning and maintenance of equipment easier, and operators can more easily access each workstation, which reduces maintenance costs and increases the service life of equipment.
[0016] In some embodiments, one circle of the reaction disk is provided with A times B plus / minus 1 reaction cup, wherein A and B are both natural numbers, and A is greater than B; the position numbers of the photoelectric collection workstation, sample addition workstation, sample stirring and mixing workstation, reagent stirring and mixing workstation, and reaction cup multi-stage cleaning workstation corresponding to the inner and outer circles of the reaction disk differ by C, and C is a natural number; the difference between the reagent addition No. 1 workstation of the inner and outer circles of the reaction disk is D, and the difference between the reagent addition No. 2 workstation of the inner and outer circles of the reaction disk is D, and D is equal to A times E minus / plus C, and E is a natural number less than B.
[0017] In some embodiments, the outer ring of the reaction disk and the inner ring of the reaction disk are evenly provided with 246 reaction cups along the circumference, and the reaction disk is provided with 246 cup positions numbered in sequence along the circumference; the outer ring reagent adding work position No. 1 is located at cup position No. 63, so the inner ring reagent adding work position No. 1 is located at cup position No. 207; the outer ring reagent adding work position No. 2 is located at cup position No. 82, so the inner ring reagent adding work position No. 2 is located at cup position No. 226. The outer ring reagent adding work position No. 1 is located at cup position No. 63, and the inner ring reagent adding work position No. 1 is located at cup position No. 207, ensuring that the angle between it and the outer ring reagent adding work position No. 1 is greater than 90°. The outer ring reagent adding work position No. 2 is located at cup position No. 82, and the inner ring reagent adding work position No. 2 is located at cup position No. 226, and the angle between it and the outer ring reagent adding work position No. 2 is also greater than 90°, realizing a far-away layout. The reasonable distribution of the outer and inner working positions avoids mutual interference between operations. Parallel operations can be performed at different working positions, which improves the overall efficiency of the test. Clear numbering and distribution make it more convenient for operators to maintain and clean.
[0018] In some of the embodiments, the outer circle photoelectric collection working position is located between cup position No. 5 and cup position No. 6, and the inner circle photoelectric collection working position is located between cup position No. 2 and cup position No. 3.
[0019] In some embodiments, the outer ring sample adding working position is located at cup position No. 166, and the inner ring sample adding working position is located at cup position No. 163.
[0020] In some embodiments, the outer circle sample stirring and mixing work station is located at cup position No. 167, and the inner circle sample stirring and mixing work station is located at cup position No. 114.
[0021] In some embodiments, the outer ring sample adding working position is located at cup position No. 166, and the inner ring sample adding working position is located at cup position No. 163.
[0022] In some embodiments, the outer circle reagent stirring and mixing work position is located at cup position No. 33, and the inner circle reagent stirring and mixing work position is located at cup position No. 30.
[0023] In some embodiments, the outer circle reaction cup multi-stage cleaning workstations are located at cup positions 4 to 13, and the inner circle reaction cup multi-stage cleaning workstations are located at cup positions 1 to 10.
[0024] In some of the embodiments, the outer circle photoelectric collection working position is located between cup position No. 5 and cup position No. 6, and the inner circle photoelectric collection working position is located between cup position No. 2 and cup position No. 3.
[0025] In some embodiments, the analyzer also includes a first reagent tray assembly disposed on the frame, the first reagent tray assembly including a first reagent tray inner ring loaded with reagent bottles and a first reagent tray outer ring, the first reagent tray outer ring is sleeved on the first reagent tray inner ring, and the first reagent tray inner ring and the first reagent tray outer ring can rotate independently of each other, the reagent bottle of the first reagent tray outer ring is filled with a first reagent, and the reagent bottle of the first reagent tray inner ring is filled with a second reagent; the first reagent needle assembly includes a first inner reagent needle and a first outer reagent needle; the first outer reagent needle is disposed on the frame and can move relative to the frame, and is used to absorb the first reagent in the reagent bottle of the outer ring of the first reagent tray and transfer it to the reaction cup of the outer ring reagent adding work position No. 1, the first inner reagent needle is disposed on the frame and can move relative to the frame, and is used to absorb the second reagent in the reagent bottle of the inner ring of the first reagent tray and transfer it to the reaction cup of the outer ring reagent adding work position No. 2. In other embodiments, the analyzer also includes a first reagent tray assembly disposed on the frame, the first reagent tray assembly including a first reagent tray inner ring loaded with reagent bottles and a first reagent tray outer ring, the first reagent tray outer ring is sleeved on the first reagent tray inner ring, and the first reagent tray inner ring and the first reagent tray outer ring can rotate independently of each other, the reagent bottles in the outer ring of the first reagent tray contain a second reagent, and the reagent bottles in the inner ring of the first reagent tray contain a first reagent; the first reagent needle assembly includes a first inner reagent needle and a first outer reagent needle; the first outer reagent needle is disposed on the frame and can move relative to the frame, and is used to absorb the second reagent in the reagent bottle in the outer ring of the first reagent tray and transfer it to the reaction cup at the outer ring reagent adding working position No. 2; the first inner reagent needle is disposed on the frame and can move relative to the frame, and is used to absorb the first reagent in the reagent bottle in the inner ring of the first reagent tray and transfer it to the reaction cup at the outer ring reagent adding working position No. 1.
[0026] In some embodiments, the motion trajectory of the first inner reagent needle does not intersect with the motion trajectory of the first outer reagent needle. The inner ring of the first reagent disk and the outer ring of the first reagent disk can rotate independently of each other. This design makes the acquisition and transfer of reagents more efficient. The rotation of the reagent disk can be flexibly adjusted as needed, so as to quickly locate the required reagent bottle, reduce waiting time, and improve overall work efficiency. Due to the independent rotation design of the inner ring and the outer ring, the equipment can better control the rotation speed and direction during operation, reduce vibration and instability caused by improper rotation, thereby improving the overall stability and reliability of the equipment. The first reagent needle assembly includes a first inner reagent needle and a first outer reagent needle, which are used to absorb reagents from the inner ring and the outer ring of the first reagent disk, respectively. This double-needle design not only improves the transfer speed of the reagent, but also allows the extraction of reagents at different positions at the same time, further improving the processing capacity of the equipment. The movement trajectories of the first internal reagent needle and the first external reagent needle do not intersect, which can avoid interference and collision between the first internal reagent needle and the first external reagent needle during movement, resulting in damage or jamming, and also ensure that no cross contamination occurs during the reagent transfer process. This design is particularly important for the analyzer, because cross contamination may cause errors in the analysis results and affect the accuracy of the experiment. The design also allows the use of multiple reagents in the same experiment at the same time to meet different experimental needs. This flexibility enables the analyzer to be widely used in a variety of biochemical detection scenarios to meet diverse experimental requirements. In summary, this implementation method further improves the efficiency, accuracy and ease of operation of the analyzer by optimizing the structural design of the first reagent disk assembly, providing users with a better analysis experience.
[0027] In some embodiments, the analyzer also includes a second reagent tray assembly disposed on the frame, the second reagent tray assembly including a second reagent tray inner ring loaded with reagent bottles and a second reagent tray outer ring, the second reagent tray outer ring is sleeved on the second reagent tray inner ring, and the second reagent tray inner ring and the second reagent tray outer ring can rotate independently of each other, the reagent bottles in the outer ring of the second reagent tray contain a first reagent, and the reagent bottles in the inner ring of the second reagent tray contain a second reagent; the second reagent needle assembly includes a second inner reagent needle and a second outer reagent needle; the second outer reagent needle is disposed on the frame and can move relative to the frame, and is used to absorb the first reagent in the reagent bottle in the outer ring of the second reagent tray and transfer it to the reaction cup of the inner ring reagent adding work position No. 1, the second inner reagent needle is disposed on the frame and can move relative to the frame, and is used to absorb the second reagent in the reagent bottle in the inner ring of the second reagent tray and transfer it to the reaction cup of the inner ring reagent adding work position No. 2. In other embodiments, the analyzer also includes a second reagent tray assembly disposed on the frame, the second reagent tray assembly includes a second reagent tray inner ring loaded with reagent bottles and a second reagent tray outer ring, the second reagent tray outer ring is sleeved on the second reagent tray inner ring, and the second reagent tray inner ring and the second reagent tray outer ring can rotate independently of each other, the reagent bottle of the second reagent tray outer ring is filled with a second reagent, and the reagent bottle of the second reagent tray inner ring is filled with a first reagent; the second reagent needle assembly includes a second inner reagent needle and a second outer reagent needle; the second outer reagent needle is disposed on the frame and can move relative to the frame, and is used to absorb the second reagent in the reagent bottle of the outer ring of the second reagent tray and transfer it to the reaction cup of the reagent No. 2 working position of the inner ring of the reaction tray, the second inner reagent needle is disposed on the frame and can move relative to the frame, and is used to absorb the first reagent in the reagent bottle of the inner ring of the second reagent tray and transfer it to the reaction cup of the reagent No. 1 working position of the inner ring of the reaction tray.
[0028] In some embodiments, the motion trajectory of the second inner reagent needle does not intersect with the motion trajectory of the second outer reagent needle. The inner ring of the second reagent disk and the outer ring of the second reagent disk can rotate independently of each other. This design makes the acquisition and transfer of reagents more efficient. The rotation of the reagent disk can be flexibly adjusted as needed, so as to quickly locate the required reagent bottle, reduce waiting time, and improve overall work efficiency. Due to the independent rotation design of the inner ring and the outer ring, the device can better control the rotation speed and direction during operation, reduce vibration and instability caused by improper rotation, thereby improving the overall stability and reliability of the device. The second reagent needle assembly includes a second inner reagent needle and a second outer reagent needle, which are respectively used to absorb the reagents of the inner ring and the outer ring of the second reagent disk. This double needle design not only improves the transfer speed of the reagent, but also allows the extraction of reagents at different positions at the same time, further improving the processing capacity of the device. The motion trajectories of the second inner reagent needle and the second outer reagent needle do not intersect, which can avoid interference and collision between the second inner reagent needle and the second outer reagent needle during movement, resulting in damage or jamming, and also ensure that cross contamination does not occur during the reagent transfer process. This design is particularly important for the analyzer because cross contamination may cause errors in the analysis results and affect the accuracy of the experiment. This design also allows the use of multiple reagents in the same experiment to meet different experimental needs. This flexibility enables the analyzer to be widely used in a variety of biochemical detection scenarios to meet diverse experimental requirements. In summary, this implementation method further improves the efficiency, accuracy and ease of operation of the analyzer by optimizing the structural design of the second reagent disc assembly, providing users with a better analysis experience.
[0029] In some embodiments, the first reagent tray assembly and the second reagent tray assembly are spaced apart from each other and are respectively located on both sides of the reaction tray. By distributing the first reagent tray assembly and the second reagent tray assembly on both sides of the reaction tray, the spatial layout of the equipment is fully utilized, crowding between the components is avoided, and the rationality of the overall design is improved. The design of the separated arrangement effectively avoids interference between different reagent tray assemblies, reduces the risk of cross contamination during operation, and ensures the accuracy and reliability of the experimental results. This layout allows the operator to more conveniently access each reagent tray when taking and transferring reagents, reduces the moving distance during operation, and improves work efficiency. The component spacing arrangement makes the equipment more convenient during maintenance and cleaning, reduces the difficulty of cleaning caused by narrow space, and improves the service life and hygiene level of the equipment.
[0030] In some embodiments, the first reagent needle assembly and the second reagent needle assembly can be mounted to the frame by linear guides and / or rotating rocker arms to achieve the movement of the first reagent needle assembly and the second reagent needle assembly relative to the frame. The use of linear guides and rotating rocker arms enables the reagent needle assembly to achieve high-precision movement, and this precise control is essential for the extraction and transfer process of the reagent, ensuring the accurate positioning and effective extraction of the reagent, thereby improving the reliability of the experiment. This design can not only support the linear movement of the reagent needle, but also achieve multi-dimensional movement, expanding the function of the device. For example, through linear guides, the reagent needle assembly can move smoothly on a set track, while the rotating rocker arm allows the reagent needle assembly to operate at different angles. This flexibility enables the device to adapt to different types of reagent bottles and reaction cup layouts to meet diverse experimental needs. For example, by rotating the rocker arm, the reagent needle can be operated at different angles to adapt to more complex experimental needs.
[0031] In some embodiments, the rotating rocker arm includes a first rocker arm assembly and a second rocker arm assembly which are arranged on the frame and whose motion trajectories do not interfere with each other, the first rocker arm assembly is arranged between the reaction disk and the first reagent disk assembly, the second rocker arm assembly is arranged between the reaction disk and the second reagent disk assembly, the first rocker arm assembly includes a first inner rocker arm and a first outer rocker arm which are arranged on the frame and whose motion trajectories do not interfere with each other, the first inner rocker arm is connected to the first inner reagent needle and is used to drive the first inner reagent needle to move, the first outer rocker arm is connected to the first outer reagent needle and is used to drive the first outer reagent needle to move, the second rocker arm assembly includes a second inner rocker arm and a second outer rocker arm which are arranged on the frame and whose motion trajectories do not interfere with each other, the second inner rocker arm is connected to the second inner reagent needle and is used to drive the second inner reagent needle to move, the second outer rocker arm is connected to the second outer reagent needle and is used to drive the second outer reagent needle to move. The independent design of the first rocker arm assembly and the second rocker arm assembly ensures that the movements of the two reagent needles will not interfere with each other during operation. This independence enables the device to process different reagents at the same time, improving the efficiency and flexibility of the experiment. The first inner rocker arm and the first outer rocker arm are respectively connected to the corresponding reagent needle, which can accurately control the movement trajectory of the reagent needle. This precise control is essential to ensure accurate extraction and transfer of reagents and reduce operational errors. By configuring the first inner rocker arm, the first outer rocker arm, the second inner rocker arm, and the second outer rocker arm separately, the design can more effectively utilize the rack space, making the device more compact in structure and adapting to the needs of different laboratory environments. At the same time, this design can also reduce the overall size of the device and facilitate operation and maintenance.
[0032] In some embodiments, the inner ring of the reaction disk and the outer ring of the reaction disk can rotate independently of each other. The inner ring and outer ring of the reaction disk are independently driven by rotation, and different test speeds and cycle timings can be set according to actual needs. This flexibility enables the device to adapt to a variety of experimental requirements and improves the efficiency and accuracy of the test. The inner ring and outer ring of the reaction disk can be set to rotate in opposite directions, and this design allows operation under the same cycle timing. In this way, the work of the inner ring and the outer ring can be effectively coordinated to ensure that the reaction conditions of different reagents and samples remain consistent during the experiment, thereby improving the reliability of the experiment. Due to the independent rotation drive of the inner ring and the outer ring, the reagent stirring cup position of the inner ring can be adjacent to the sample stirring cup position of the outer ring, and vice versa. This design makes the stirring and mixing between reagents and samples more efficient, can better promote the reaction, and improve the uniformity and speed of the reaction.
[0033] In some embodiments, the analyzer also includes a photometer, a cleaning mechanism, a sample stirring assembly and a reagent stirring assembly which are arranged on the frame and distributed around the reaction disk; the photometer can respectively perform photoelectric data collection on the reaction cups on the outer circle photoelectric collection workstation and the inner circle photoelectric collection workstation to obtain the test reaction data in the reaction cups; the cleaning mechanism can perform multi-stage cleaning on the reaction cups on the outer circle reaction cup multi-stage cleaning workstation and the inner circle reaction cup multi-stage cleaning workstation; the sample stirring assembly can perform sample stirring and mixing actions on the reaction cups on the outer circle sample stirring and mixing workstation and the inner circle sample stirring and mixing workstation to mix the first reagent and the sample in the reaction cup to form a reaction liquid; the reagent stirring assembly can perform reagent stirring and mixing actions on the reaction cups on the outer circle reagent stirring and mixing workstation and the inner circle reagent stirring and mixing workstation to mix the second reagent in the reaction cup and the reaction liquid.
[0034] In some embodiments, the analyzer further includes a track and a sample needle assembly, the track is arranged on the frame, and the sample needle assembly can be mounted to the frame through a linear guide and / or a rotating rocker arm to achieve the movement of the sample needle assembly relative to the frame; the sample needle assembly is arranged between the track and the reaction disk, and the sample needle assembly includes a first sample needle and a second sample needle arranged on the frame and whose movement trajectories do not interfere with each other, the first sample needle is used to absorb the sample on the track and transfer it to the reaction cup of the inner ring plus sample working position of the reaction disk, and the second sample needle is used to absorb the sample on the track and transfer it to the reaction cup of the outer ring plus sample working position. The sample needle assembly can be mounted to the frame through a linear guide and / or a rotating rocker arm to achieve the flexible movement of the sample needle assembly relative to the frame. This design improves the efficiency of sample transfer, so that the sample can be quickly transferred from the track to the designated working position of the reaction disk. The movement trajectories of the first sample needle and the second sample needle do not interfere with each other, ensuring that no collision or interference occurs during the sample transfer process. This design improves the safety and stability of the device and avoids potential errors in the sample transfer process. The first sample needle is responsible for transferring the sample from the track to the cuvette with the inner ring plus sample working position, while the second sample needle transfers the sample to the cuvette with the outer ring plus sample working position. This division of labor design enables the analyzer to process multiple samples at the same time, improving the parallel processing capability and overall efficiency of the experiment. The design of the sample needle assembly between the track and the reaction disk effectively utilizes the equipment space and reduces the footprint of the equipment. This compact layout makes the equipment more flexible and easy to operate in a laboratory environment. Through the integration of the track and sample needle assembly, the analyzer achieves a higher level of automation and reduces the need for manual intervention. This automation function not only improves work efficiency, but also reduces the risk of human error and ensures the reliability of experimental results. BRIEF DESCRIPTION OF THE DRAWINGS
[0035] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the conventional technology, the drawings required for use in the embodiments or the conventional technology descriptions are briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.
[0036] Figure 1 A schematic structural diagram of a reaction disk of an analyzer provided in one embodiment of the present invention.
[0037] Figure 2 A schematic diagram of the structure of an analyzer provided in one embodiment of the present invention.
[0038] Reference numerals:
[0039] 1. Outer circle photoelectric collection workstation; 2. Outer circle reagent adding workstation No. 1; 3. Outer circle sample adding workstation; 4. Outer circle sample stirring and mixing workstation; 5. Outer circle reagent adding workstation No. 2; 6. Outer circle reagent stirring and mixing workstation; 7. Outer circle reaction cup multi-stage cleaning workstation; 11. Inner circle photoelectric collection workstation; 12. Inner circle reagent adding workstation No. 1; 13. Inner circle sample adding workstation; 14. Inner circle sample stirring and mixing workstation; 15. Inner circle reagent adding workstation No. 2; 16. Inner circle Reagent stirring and mixing workstation; 17, inner circle reaction cup multi-stage cleaning workstation; 10, analyzer; 100, rack; 210, photometer; 220, cleaning mechanism; 230, sample stirring assembly; 240, reagent stirring assembly; 300, reaction disk; 310, inner circle of reaction disk; outer circle photoelectric collection workstation, outer circle reagent adding workstation No. 1, outer circle sample adding workstation, outer circle sample stirring and mixing workstation, outer circle reagent adding workstation No. 2, outer circle reagent stirring and mixing workstation and outer circle reaction The multi-stage cleaning workstation of the reaction cup; 320, the outer ring of the reaction disk; the photoelectric collection workstation of the inner ring, the No. 1 reagent adding workstation of the inner ring, the sample adding workstation of the inner ring, the sample stirring and mixing workstation of the inner ring, the No. 2 reagent adding workstation of the inner ring, the reagent stirring and mixing workstation of the inner ring and the multi-stage cleaning workstation of the inner ring reaction cup; 400, the sample needle assembly; 410, the first sample needle; 420, the second sample needle; 510, the first reagent disk assembly; 511, the inner ring of the first reagent disk; 512, the outer ring of the first reagent disk; 5 20. Second reagent disk assembly; 521. Second reagent disk inner ring; 522. Second reagent disk outer ring; 610. First reagent needle assembly; 611. First inner reagent needle; 612. First outer reagent needle; 620. Second reagent needle assembly; 621. Second inner reagent needle; 622. Second outer reagent needle; 710. First rocker arm assembly; 711. First inner rocker arm; 712. First outer rocker arm; 720. Second rocker arm assembly; 721. Second inner rocker arm; 722. Second outer rocker arm. DETAILED DESCRIPTION
[0040] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific embodiments of the present invention are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present invention, so the present invention is not limited by the specific embodiments disclosed below.
[0041] See also Figure 1 and Figure 2In some embodiments, the present invention provides an analyzer 10 , which includes a frame 100 , a reaction disk 300 , a first reagent needle assembly 610 , and a second reagent needle assembly 620 . The reaction disk 300 is arranged on the frame 100 and includes a reaction disk inner ring 310 loaded with reaction cups and a reaction disk outer ring 320; the rotation track of the reaction disk outer ring 320 is provided with an outer ring photoelectric collection workstation 1, an outer ring reagent adding workstation No. 1 2, an outer ring sample adding workstation 3, an outer ring sample stirring and mixing workstation 4, an outer ring reagent adding workstation No. 2 5, an outer ring reagent stirring and mixing workstation 6 and an outer ring reaction cup multi-stage cleaning workstation 7; the rotation track of the reaction disk inner ring 310 is provided with an inner ring photoelectric collection workstation 11, an inner ring reagent adding workstation No. 1 12, an inner ring sample adding workstation 13, an inner ring sample stirring and mixing workstation 14, an inner ring reagent adding workstation No. 2 15, an inner ring reagent stirring and mixing workstation 16 and an inner ring reaction cup multi-stage cleaning workstation 17; the first reagent needle assembly 610 is arranged on the frame 100 and can move relative to the frame 100, and is used to add the first reagent needle assembly 610 to the reaction disk inner ring 310; The first reagent is transferred to the reaction cup of the outer ring reagent adding workstation No. 1 2 and the outer ring reagent adding workstation No. 2 5; the second reagent needle assembly 620 is arranged on the frame 100 and can move relative to the frame 100, and is used to transfer the second reagent to the reaction cup of the inner ring reagent adding workstation No. 1 12 and the inner ring reagent adding workstation No. 2 15; wherein, the angle between the line connecting the outer ring reagent adding workstation No. 1 2 and the center of the reaction disk 300 and the line connecting the inner ring reagent adding workstation No. 1 12 and the center of the reaction disk 300 is greater than 90°; the angle between the line connecting the outer ring reagent adding workstation No. 2 5 and the center of the reaction disk 300 and the line connecting the inner ring reagent adding workstation No. 2 15 and the center of the reaction disk 300 is greater than 90°; the first reagent needle assembly 610 and the second reagent needle assembly 620 are located on both sides of the reaction disk 300.
[0042] The above-mentioned analyzer 10 can at least achieve the following beneficial effects: the angle between the line connecting the outer ring reagent workstation No. 1 2 and the center of the reaction disk 300 and the line connecting the inner ring reagent workstation No. 1 12 and the center of the reaction disk 300 is greater than 90°, that is, the positions of the outer ring reagent workstation No. 1 2 and the inner ring reagent workstation No. 1 12 are relatively far away, almost located on both sides of the reaction disk 300; the angle between the line connecting the outer ring reagent workstation No. 2 5 and the center of the reaction disk 300 and the line connecting the inner ring reagent workstation No. 2 15 and the center of the reaction disk 300 is greater than 90°, that is, the positions of the outer ring reagent workstation No. 2 5 and the inner ring reagent workstation No. 2 15 are relatively far away, almost located on both sides of the reaction disk 300, so the corresponding first reagent needle assembly 610 and the second reagent needle assembly 620 can also be arranged on both sides of the reaction disk 300, which can avoid the component layout being too crowded, which not only improves the convenience of operation, but also reduces the risk of operational errors caused by narrow space. The dispersed workstation layout effectively avoids mutual interference between different operations, ensuring that operations such as sample filling, reagent addition, and photoelectric detection can be performed independently, improving the overall stability of the equipment. Reasonable layout makes it easier to clean and maintain the equipment, and operators can more easily access each workstation, reducing maintenance costs and increasing the service life of the equipment.
[0043] In some embodiments, one circle of the reaction disk is provided with A times B plus / minus 1 reaction cup, wherein A and B are both natural numbers, and A is greater than B; the position numbers of the photoelectric collection workstation, sample addition workstation, sample stirring and mixing workstation, reagent stirring and mixing workstation, and reaction cup multi-stage cleaning workstation corresponding to the inner and outer circles of the reaction disk differ by C, and C is a natural number; the difference between the reagent addition No. 1 workstation of the inner and outer circles of the reaction disk is D, and the difference between the reagent addition No. 2 workstation of the inner and outer circles of the reaction disk is D, and D is equal to A times E minus / plus C, and E is a natural number less than B.
[0044] like Figure 1 and Figure 2As shown, in some embodiments, the outer ring 320 of the reaction disk and the inner ring 310 of the reaction disk are evenly provided with 246 reaction cups along the circumferential direction, and the reaction disk 300 is provided with 246 cup positions numbered in sequence along the circumferential direction; the outer ring reagent adding work position 2 is located at the 63rd cup position, so the inner ring reagent adding work position 12 is located at the 207th cup position; the outer ring reagent adding work position 5 is located at the 82nd cup position, so the inner ring reagent adding work position 15 is located at the 226th cup position. The outer ring reagent adding work position 2 is located at the 63rd cup position, and the inner ring reagent adding work position 12 is located at the 207th cup position, ensuring that the angle between it and the outer ring reagent adding work position 2 is greater than 90°. The outer ring reagent adding workstation 5 is located at cup position 82, and the inner ring reagent adding workstation 15 is located at cup position 226. It is also ensured that the angle between it and the outer ring reagent adding workstation 5 is greater than 90° to achieve a far-away layout. The reasonable distribution of the outer and inner ring workstations avoids mutual interference between operations. Parallel operations can be performed at different workstations, which improves the overall efficiency of the test. Clear numbering and distribution make it more convenient for operators to maintain and clean.
[0045] like Figure 1 and Figure 2 As shown, in some embodiments, the outer ring sample adding work position 3 is located at cup position No. 166, and the inner ring sample adding work position 13 is located at cup position No. 163. The outer ring sample stirring and mixing work position 4 is located at cup position No. 167, and the inner ring sample stirring and mixing work position 14 is located at cup position No. 114. The outer ring sample adding work position 3 is located at cup position No. 166, and the inner ring sample adding work position 13 is located at cup position No. 163. The outer ring reagent stirring and mixing work position 6 is located at cup position No. 33, and the inner ring reagent stirring and mixing work position 16 is located at cup position No. 30. The outer ring reaction cup multi-stage cleaning work position 7 is located at cup positions No. 4-13, and the inner ring reaction cup multi-stage cleaning work position 17 is located at cup positions No. 1-10. Specifically, the following work positions are arranged circumferentially along the reaction disk 300:
[0046] Position 1: Outer ring photoelectric collection working position 1; located between cup positions 5 and 6 on the outer ring of the reaction disk;
[0047] Position 2: outer ring reagent adding No. 1 working position 2; located at cup position 63 on the outer ring of the reaction disk;
[0048] Position 3: Outer ring plus sample working position 3; located at cup position 166 on the outer ring of the reaction disk;
[0049] Position 4: Outer ring sample stirring and mixing work position 4; located at cup position 167 on the outer ring of the reaction disk;
[0050] Position 5: Outer ring reagent adding No. 2 working position 5; located at cup position 82 on the outer ring of the reaction disk;
[0051] Position 6: Outer ring reagent stirring and mixing work position 6; located at cup position 33 on the outer ring of the reaction disk;
[0052] Position 7: Multi-stage cleaning position 7 for outer reaction cups; located at cup positions 4 to 13 on the outer ring of the reaction disk;
[0053] Position 11: Inner circle photoelectric collection working position 11; located between cup positions 2 and 3 on the inner circle of the reaction disk;
[0054] Position 12: Inner circle reagent adding No. 1 working position 12; located at cup position 207 in the inner circle of the reaction disk;
[0055] Position 13: Inner circle sample adding working position 13; located at cup position 163 in the inner circle of the reaction plate;
[0056] Position 14: Inner circle sample stirring and mixing work position 14; located at cup position 114 in the inner circle of the reaction plate;
[0057] Position 15: Inner circle reagent adding No. 2 working position 15; located at cup position 226 in the inner circle of the reaction disk;
[0058] Position 16: Inner circle reagent stirring and mixing work position 16; located at cup position 30 in the inner circle of the reaction disk;
[0059] Position 17: Inner circle reaction cup multi-stage cleaning work position 17; located at cup positions 1 to 10 in the reaction tray.
[0060] When working, the reaction disk 300 performs periodic rotation and stop actions, and the single cycle time is 3 seconds. In each cycle, the reaction disk 300 rotates 49 cup positions counterclockwise, then stops and waits for a fixed time to complete a cycle action. After 5 consecutive cycles, 245 reaction cups are rotated, and the entire reaction disk 300 advances one cup position clockwise. During the stop time of the reaction disk 300, each component performs corresponding operations at the corresponding working position. The reaction cup at the cleaning work position performs cleaning; the reaction cup at the reagent adding work position No. 1 performs the addition of the first reagent; the reaction cup at the sample adding work position performs the addition of the sample; the reaction cup at the sample stirring and mixing work position performs the sample stirring and mixing; the reaction cup at the reagent adding work position No. 2 performs the addition of the second reagent; the reaction cup at the reagent stirring and mixing work position performs the reagent stirring and mixing. When the reaction disk 300 rotates, the reaction cup passing through the photoelectric collection work position performs the photoelectric collection operation. A single cycle is 3s, supporting a test speed of 2400 tests / hour.
[0061] Workflow: In the 1st, 6th, 11th, 16th, 21st, 26th, 31st, 36th, 41st and 46th cycles, the reaction cups of the inner circle 310 of the reaction disk stop at the 10th-order cleaning cup position corresponding to position 17 in turn, and cleaning is performed; the reaction cups of the outer circle 320 of the reaction disk stop at the 10th-order cleaning cup position corresponding to position 7 in turn, and cleaning is performed; in the 47th cycle, the reaction cups of the inner circle 310 of the reaction disk stop at position 12, and the first reagent component is added; in the 50th cycle, the reaction cups of the outer circle 320 of the reaction disk stop at position 2, and the first reagent component is added; in the 73rd cycle, the reaction cups of the inner circle 310 of the reaction disk stop at position 13, and the sample addition operation is performed, and the reaction cups of the outer circle 320 of the reaction disk stop at position 3, and the sample addition operation is performed; in the 74th cycle, the reaction cups of the inner circle 310 and the outer circle 320 of the reaction disk stop The reaction cups of the inner ring 310 of the reaction disk stop at position 14 and position 4, and perform the stirring and mixing operation of the first reagent component and the sample; in the 142nd cycle, the reaction cup of the inner ring 310 of the reaction disk stops at position 15, and the second reagent component is added; in the 145th cycle, the reaction cup of the outer ring 320 of the reaction disk stops at position 5, and the second reagent component is added; in the 146th cycle, the reaction cup of the outer ring 320 of the reaction disk stops at position 16 and position 6, and performs the stirring and mixing operation of the second reagent component and the reaction liquid; in the 247th cycle, the reaction cups of the inner ring 310 of the reaction disk and the outer ring 320 of the reaction disk complete the test, stop at position 17 and position 7 again, start cleaning, and enter the next test work cycle; in the above work cycles, when the reaction cups of the inner ring 310 of the reaction disk and the outer ring 320 of the reaction disk pass through position 11 and position 1, the photoelectric collection operation is completed.
[0062] like Figure 1 and Figure 2As shown, in some embodiments, the analyzer 10 further includes a first reagent disk assembly 510 disposed on the frame 100, the first reagent disk assembly 510 includes a first reagent disk inner ring 511 loaded with reagent bottles and a first reagent disk outer ring 512, the first reagent disk outer ring 512 is sleeved on the first reagent disk inner ring 511, and the first reagent disk inner ring 511 and the first reagent disk outer ring 512 can rotate independently of each other, the reagent bottle of the first reagent disk outer ring 512 is filled with a first reagent, and the reagent bottle of the first reagent disk inner ring 511 is filled with a second reagent; The first reagent needle assembly 610 includes a first inner reagent needle 611 and a first outer reagent needle 612; the first outer reagent needle 612 is arranged on the frame 100 and can move relative to the frame 100, and is used to absorb the first reagent in the reagent bottle of the outer ring 512 of the first reagent disk and transfer it to the reaction cup of the outer ring reagent adding work position No. 1 2, and the first inner reagent needle 611 is arranged on the frame 100 and can move relative to the frame 100, and is used to absorb the second reagent in the reagent bottle of the inner ring 511 of the first reagent disk and transfer it to the reaction cup of the outer ring reagent adding work position No. 2 5. In other embodiments, the analyzer 10 further includes a first reagent disk assembly 510 disposed on the frame 100, the first reagent disk assembly 510 including a first reagent disk inner ring 511 loaded with reagent bottles and a first reagent disk outer ring 512, the first reagent disk outer ring 512 is sleeved on the first reagent disk inner ring 511, and the first reagent disk inner ring 511 and the first reagent disk outer ring 512 can rotate independently of each other, the reagent bottle of the first reagent disk outer ring 512 is filled with a second reagent, and the reagent bottle of the first reagent disk inner ring 511 is filled with a first reagent; the first The reagent needle assembly 610 includes a first inner reagent needle 611 and a first outer reagent needle 612; the first outer reagent needle 612 is arranged on the frame 100 and can move relative to the frame 100, and is used to absorb the second reagent in the reagent bottle of the outer ring 512 of the first reagent disk and transfer it to the reaction cup of the outer ring reagent adding work position No. 2 5; the first inner reagent needle 611 is arranged on the frame 100 and can move relative to the frame 100, and is used to absorb the first reagent in the reagent bottle of the inner ring 511 of the first reagent disk and transfer it to the reaction cup of the outer ring reagent adding work position No. 1 2.
[0063] Further, the motion trajectory of the first inner reagent needle 611 does not intersect with the motion trajectory of the first outer reagent needle 612. The first reagent disk inner ring 511 and the first reagent disk outer ring 512 can rotate independently of each other. This design makes the acquisition and transfer of reagents more efficient. The rotation of the reagent disk can be flexibly adjusted as needed, so as to quickly locate the required reagent bottle, reduce waiting time, and improve overall work efficiency. Due to the independent rotation design of the inner ring and the outer ring, the device can better control the rotation speed and direction during operation, reduce vibration and instability caused by improper rotation, thereby improving the overall stability and reliability of the device. The first reagent needle assembly 610 includes a first inner reagent needle 611 and a first outer reagent needle 612, which are respectively used to absorb the reagents in the inner ring 511 and the outer ring of the first reagent disk. This double needle design not only improves the transfer speed of the reagent, but also allows the extraction of reagents in different positions at the same time, further improving the processing capacity of the device. The movement trajectories of the first internal reagent needle 611 and the first external reagent needle 612 do not intersect, which can avoid interference and collision between the first internal reagent needle 611 and the first external reagent needle 612 during movement, resulting in damage or jamming, and also ensure that cross contamination does not occur during the reagent transfer process. This design is particularly important for the analyzer 10, because cross contamination may cause errors in the analysis results and affect the accuracy of the experiment. The design also allows the use of multiple reagents in the same experiment at the same time to meet different experimental requirements. This flexibility enables the analyzer 10 to be widely used in a variety of biochemical detection scenarios to meet diverse experimental requirements. In summary, this embodiment further improves the efficiency, accuracy and ease of operation of the analyzer 10 by optimizing the structural design of the first reagent disk assembly 510, providing users with a better analysis experience.
[0064] like Figure 1 and Figure 2As shown, in some embodiments, the analyzer 10 further includes a second reagent disk assembly 520 disposed on the frame 100, the second reagent disk assembly 520 includes a second reagent disk inner ring 521 loaded with reagent bottles and a second reagent disk outer ring 522, the second reagent disk outer ring 522 is sleeved on the second reagent disk inner ring 521, and the second reagent disk inner ring 521 and the second reagent disk outer ring 522 can rotate independently of each other, the reagent bottle of the second reagent disk outer ring 522 is filled with a first reagent, and the reagent bottle of the second reagent disk inner ring 521 is filled with a second reagent; The second reagent needle assembly 620 includes a second inner reagent needle 621 and a second outer reagent needle 622; the second outer reagent needle 622 is arranged on the frame 100 and can move relative to the frame 100, and is used to absorb the first reagent in the reagent bottle of the outer ring 522 of the second reagent disk and transfer it to the reaction cup of the inner ring reagent adding work position No. 1 12, and the second inner reagent needle 621 is arranged on the frame 100 and can move relative to the frame 100, and is used to absorb the second reagent in the reagent bottle of the inner ring 521 of the second reagent disk and transfer it to the reaction cup of the inner ring reagent adding work position No. 2 15. In other embodiments, the analyzer 10 further includes a second reagent disk assembly 520 disposed on the frame 100, the second reagent disk assembly 520 including a second reagent disk inner ring 521 loaded with reagent bottles and a second reagent disk outer ring 522, the second reagent disk outer ring 522 is sleeved on the second reagent disk inner ring 521, and the second reagent disk inner ring 521 and the second reagent disk outer ring 522 can rotate independently of each other, the reagent bottle of the second reagent disk outer ring 522 is filled with a second reagent, and the reagent bottle of the second reagent disk inner ring 521 is filled with a first reagent; the second reagent needle assembly 62 0 includes a second inner reagent needle 621 and a second outer reagent needle 622; the second outer reagent needle 622 is arranged on the frame 100 and can move relative to the frame 100, and is used to absorb the second reagent in the reagent bottle of the second reagent disk outer ring 522 and transfer it to the reaction cup of the reagent No. 2 working position 15 of the inner ring 310 of the reaction disk, and the second inner reagent needle 621 is arranged on the frame 100 and can move relative to the frame 100, and is used to absorb the first reagent in the reagent bottle of the second reagent disk inner ring 521 and transfer it to the reaction cup of the reagent No. 1 working position 12 of the inner ring 310 of the reaction disk.
[0065] Further, the motion trajectory of the second inner reagent needle 621 does not intersect with the motion trajectory of the second outer reagent needle 622. The second reagent disk inner ring 521 and the second reagent disk outer ring 522 can rotate independently of each other. This design makes the acquisition and transfer of reagents more efficient. The rotation of the reagent disk can be flexibly adjusted as needed, so as to quickly locate the required reagent bottle, reduce waiting time, and improve overall work efficiency. Due to the independent rotation design of the inner ring and the outer ring, the device can better control the rotation speed and direction during operation, reduce vibration and instability caused by improper rotation, thereby improving the overall stability and reliability of the device. The second reagent needle assembly 620 includes a second inner reagent needle 621 and a second outer reagent needle 622, which are used to absorb the reagents of the inner ring 521 and the outer ring of the second reagent disk, respectively. This double-needle design not only improves the transfer speed of the reagent, but also allows the extraction of reagents at different positions at the same time, further improving the processing capacity of the device. The movement trajectories of the second inner reagent needle 621 and the second outer reagent needle 622 do not intersect, which can avoid interference and collision between the second inner reagent needle 621 and the second outer reagent needle 622 during movement, resulting in damage or jamming, and also ensure that cross contamination does not occur during the reagent transfer process. This design is particularly important for the analyzer 10, because cross contamination may cause errors in the analysis results and affect the accuracy of the experiment. The design also allows the use of multiple reagents in the same experiment at the same time to meet different experimental requirements. This flexibility enables the analyzer 10 to be widely used in a variety of biochemical detection scenarios to meet diverse experimental requirements. In summary, this embodiment further improves the efficiency, accuracy and ease of operation of the analyzer 10 by optimizing the structural design of the second reagent disk assembly 520, providing users with a better analysis experience.
[0066] like Figure 1 and Figure 2 As shown, in some embodiments, the first reagent disc assembly 510 and the second reagent disc assembly 520 are arranged at intervals from each other and are respectively located on both sides of the reaction disc 300. By distributing the first reagent disc assembly 510 and the second reagent disc assembly 520 on both sides of the reaction disc 300, the spatial layout of the equipment is fully utilized, the crowding between the components is avoided, and the rationality of the overall design is improved. The design of the separated arrangement effectively avoids the interference between different reagent disc assemblies, reduces the risk of cross contamination during operation, and ensures the accuracy and reliability of the experimental results. This layout allows the operator to more conveniently contact each reagent disc when taking and transferring the reagent, reduces the moving distance during operation, and improves work efficiency. The component interval arrangement makes the equipment more convenient when maintaining and cleaning, reduces the cleaning difficulty caused by narrow space, and improves the service life and sanitation level of the equipment.
[0067] like Figure 1 and Figure 2 As shown, in some embodiments, the first reagent needle assembly 610 and the second reagent needle assembly 620 can be mounted to the frame 100 by linear guides and / or rotating rocker arms to achieve the movement of the first reagent needle assembly 610 and the second reagent needle assembly 620 relative to the frame 100. The use of linear guides and rotating rocker arms enables the reagent needle assembly to achieve high-precision movement, and this precise control is essential for the extraction and transfer process of the reagent, ensuring the accurate positioning and effective extraction of the reagent, thereby improving the reliability of the experiment. This design can not only support the linear movement of the reagent needle, but also achieve multi-dimensional movement, expanding the function of the device. For example, through linear guides, the reagent needle assembly can move smoothly on a set track, while the rotating rocker arm allows the reagent needle assembly to operate at different angles. This flexibility enables the device to adapt to different types of reagent bottles and reaction cup layouts to meet diverse experimental needs. For example, by rotating the rocker arm, the reagent needle can be operated at different angles to adapt to more complex experimental needs.
[0068] like Figure 1 and Figure 2As shown, in some embodiments, the rotating rocker arm includes a first rocker arm assembly 710 and a second rocker arm assembly 720 which are arranged on the frame 100 and whose motion trajectories do not interfere with each other, the first rocker arm assembly 710 is arranged between the reaction disk 300 and the first reagent disk assembly 510, the second rocker arm assembly 720 is arranged between the reaction disk 300 and the second reagent disk assembly 520, the first rocker arm assembly 710 includes a first inner rocker arm 711 and a first outer rocker arm 712 which are arranged on the frame 100 and whose motion trajectories do not interfere with each other, the first inner rocker arm 711 and the first inner reagent disk assembly 510 are arranged between the first rocker arm assembly 710 and the first outer rocker arm 712, the first inner rocker arm 711 and the first inner reagent disk assembly 510 are arranged between the first rocker arm assembly 710 and the first outer rocker arm 712. The first inner reagent needle 611 is connected and used to drive the first inner reagent needle 611 to move, the first outer rocker arm 712 is connected to the first outer reagent needle 612 and used to drive the first outer reagent needle 612 to move, the second rocker arm assembly 720 includes a second inner rocker arm 721 and a second outer rocker arm 722 which are arranged on the frame 100 and whose motion trajectories do not interfere with each other, the second inner rocker arm 721 is connected to the second inner reagent needle 621 and used to drive the second inner reagent needle 621 to move, and the second outer rocker arm 722 is connected to the second outer reagent needle 622 and used to drive the second outer reagent needle 622 to move. The independent design of the first rocker arm assembly 710 and the second rocker arm assembly 720 ensures that the movement of the two reagent needles will not interfere with each other during operation. This independence enables the device to process different reagents at the same time, improving the efficiency and flexibility of the experiment. The first inner rocker arm 711 and the first outer rocker arm 712 are respectively connected to the corresponding reagent needles, and can accurately control the motion trajectory of the reagent needle. This precise control is crucial to ensure the accurate extraction and transfer of reagents, reducing operational errors. By configuring the first inner rocker arm 711, the first outer rocker arm 712, the second inner rocker arm 721 and the second outer rocker arm 722 separately, the design can more effectively utilize the rack 100 space, making the device more compact in structure and adapting to the needs of different laboratory environments. At the same time, this design can also reduce the overall volume of the device and facilitate operation and maintenance.
[0069] like Figure 1 and Figure 2As shown, in some embodiments, the inner ring 310 of the reaction disk and the outer ring 320 of the reaction disk can rotate independently of each other. The inner ring 310 and the outer ring of the reaction disk are independently driven by rotation, and different test speeds and cycle timings can be set according to actual needs. This flexibility enables the device to adapt to a variety of experimental requirements and improves the efficiency and accuracy of the test. The inner ring 310 and the outer ring of the reaction disk can be set to rotate in opposite directions, and this design allows operation under the same cycle timing. In this way, the work of the inner ring and the outer ring can be effectively coordinated to ensure that the reaction conditions of different reagents and samples remain consistent during the experiment, thereby improving the reliability of the experiment. Due to the independent rotation drive of the inner ring and the outer ring, the reagent stirring cup position of the inner ring can be adjacent to the sample stirring cup position of the outer ring, and vice versa. This design makes the stirring and mixing between reagents and samples more efficient, can better promote the reaction, and improve the uniformity and speed of the reaction.
[0070] like Figure 1 and Figure 2 As shown, in some embodiments, the analyzer 10 further includes a photometer 210, a cleaning mechanism 220, a sample stirring assembly 230, and a reagent stirring assembly 240, which are arranged on the rack 100 and distributed around the reaction disk 300; the photometer 210 can respectively perform photoelectric data collection on the reaction cups on the outer ring photoelectric collection workstation 1 and the inner ring photoelectric collection workstation 11 to obtain the test reaction data in the reaction cups; the cleaning mechanism 220 can perform photoelectric data collection on the outer ring reaction cup multi-stage cleaning workstation 7 and the inner ring reaction cup multi-stage cleaning workstation 11. The reaction cup on the cup multi-stage cleaning workstation 17 performs multi-stage cleaning; the sample stirring component 230 can perform sample stirring and mixing actions on the reaction cups on the outer circle sample stirring and mixing workstation 4 and the inner circle sample stirring and mixing workstation 144, and mix the first reagent and the sample in the reaction cup to form a reaction liquid; the reagent stirring component 240 can perform reagent stirring and mixing actions on the reaction cups on the outer circle reagent stirring and mixing workstation 6 and the inner circle reagent stirring and mixing workstation 16, and mix the second reagent in the reaction cup and the reaction liquid.
[0071] like Figure 1 and Figure 2As shown, in some embodiments, the analyzer 10 further includes a track and a sample needle assembly 400, the track is provided on the frame 100, the sample needle assembly 400 can be mounted to the frame 100 through a linear guide and / or a rotating rocker arm to achieve the movement of the sample needle assembly 400 relative to the frame 100; the sample needle assembly 400 is provided between the track and the reaction disk 300, the sample needle assembly 400 includes a first sample needle 410 and a second sample needle 420 provided in the frame 100 and having movement trajectories that do not interfere with each other, the first sample needle 410 is used to absorb the sample on the track and transfer it to the reaction cup of the inner circle 310 of the reaction disk plus the sample working position, and the second sample needle 420 is used to absorb the sample on the track and transfer it to the reaction cup of the outer circle plus the sample working position 3. The sample needle assembly 400 can be mounted to the frame 100 through a linear guide and / or a rotating rocker arm, so as to achieve the flexible movement of the sample needle assembly 400 relative to the frame 100. This design improves the efficiency of sample transfer, allowing samples to be quickly transferred from the track to the designated working position of the reaction disk 300. The movement trajectories of the first sample needle 410 and the second sample needle 420 do not interfere with each other, ensuring that no collision or interference occurs during the sample transfer process. This design improves the safety and stability of the device and avoids potential errors in the sample transfer process. The first sample needle 410 is responsible for transferring the sample from the track to the reaction cup of the inner circle plus sample working position 13, while the second sample needle 420 transfers the sample to the reaction cup of the outer circle plus sample working position 3. This division of labor design enables the analyzer 10 to process multiple samples at the same time, improving the parallel processing capability and overall efficiency of the experiment. The design of the sample needle assembly 400 between the track and the reaction disk 300 effectively utilizes the equipment space and reduces the footprint of the equipment. This compact layout makes the device more flexible and easy to operate in a laboratory environment. Through the integration of the track and the sample needle assembly 400, the analyzer 10 achieves a higher level of automation and reduces the need for manual intervention. This automation function not only improves work efficiency, but also reduces the risk of human error and ensures the reliability of experimental results.
[0072] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.
[0073] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the patent application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.
[0074] In the description of the present invention, it should be understood that if the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like appear, the orientation or position relationship indicated by these terms is based on the orientation or position relationship shown in the accompanying drawings, which is only for the convenience of describing the present invention and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention.
[0075] In addition, if the terms "first" or "second" appear, these terms are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, the features defined as "first" or "second" may explicitly or implicitly include at least one of the features. In the description of the present invention, if the term "plurality" appears, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.
[0076] In the present invention, unless otherwise clearly defined and limited, if the terms "installed", "connected", "connected", "fixed" and the like appear, these terms should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral one; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.
[0077] In the present invention, unless otherwise clearly specified and limited, if there is a description that a first feature is "above" or "below" a second feature, etc., or the like, it may mean that the first and second features are in direct contact, or that the first and second features are in indirect contact through an intermediate medium. Moreover, the first feature being "above", "above" and "above" the second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. The first feature being "below", "below" and "below" the second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.
[0078] It should be noted that if an element is referred to as being "fixed to" or "disposed on" another element, it may be directly on the other element or there may be a central element. If an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. If present, the terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used in the present invention are for illustrative purposes only and do not represent the only implementation method.
[0079] In the description of this specification, the description of reference terms "one embodiment", "other implementation methods", etc. means that the specific features, structures, materials or features described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic descriptions of the above terms do not necessarily refer to the same embodiment or example. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by technicians in the technical field of the present invention. The terms used in the specification of the present invention herein are only for the purpose of describing specific embodiments and are not intended to limit the present invention.
Claims
1. An analyzer, characterized in that: include: frame; A reaction disk, arranged on the frame and comprising an inner ring of the reaction disk loaded with reaction cups and an outer ring of the reaction disk; The outer ring of the reaction disk has an outer ring photoelectric collection workstation, an outer ring reagent adding workstation No. 1, an outer ring sample adding workstation, an outer ring sample stirring and mixing workstation, an outer ring reagent adding workstation No. 2, an outer ring reagent stirring and mixing workstation and an outer ring reaction cup multi-stage cleaning workstation on the rotation track of the outer ring; The rotation track of the inner circle of the reaction disk is provided with an inner circle photoelectric collection work station, an inner circle reagent adding work station No. 1, an inner circle sample adding work station, an inner circle sample stirring and mixing work station, an inner circle reagent adding work station No. 2, an inner circle reagent stirring and mixing work station and an inner circle reaction cup multi-stage cleaning work station; A first reagent needle assembly, which is disposed on the frame and can move relative to the frame, and is used to transfer the reagent to the reaction cups at the outer ring reagent adding work position No. 1 and the outer ring reagent adding work position No. 2; A second reagent needle assembly, which is disposed on the frame and can move relative to the frame, and is used to transfer the reagent to the reaction cups at the inner circle reagent adding work position No. 1 and the inner circle reagent adding work position No. 2; Among them, the angle between the line connecting the outer ring plus reagent No. 1 working position and the center of the reaction disk and the line connecting the inner ring plus reagent No. 1 working position and the center of the reaction disk is greater than 90°; the angle between the line connecting the outer ring plus reagent No. 2 working position and the center of the reaction disk and the line connecting the inner ring plus reagent No. 2 working position and the center of the reaction disk is greater than 90°; the first reagent needle assembly and the second reagent needle assembly are located on both sides of the reaction disk.
2. The analyzer according to claim 1, characterized in that One circle of the reaction disk is provided with A times B plus / minus 1 reaction cup, wherein A and B are both natural numbers, and A is greater than B; the position numbers of the photoelectric collection workstation, sample adding workstation, sample stirring and mixing workstation, reagent stirring and mixing workstation and reaction cup multi-stage cleaning workstation corresponding to the inner and outer circles of the reaction disk differ by C, and C is a natural number; the difference between the reagent adding workstation No. 1 of the inner and outer circles of the reaction disk is D, and the difference between the reagent adding workstation No. 2 of the inner and outer circles of the reaction disk is D, and D is equal to A times E minus / plus C, and E is a natural number less than B.
3. The analysis method according to claim 2, characterized in that: There are 246 reaction cups evenly arranged on the outer ring of the reaction disk and the inner ring of the reaction disk along the circumferential direction, and 246 cup positions numbered sequentially are arranged along the circumferential direction on the reaction disk; the work position No. 1 for adding reagent to the outer ring is located at the cup position No. 63, so the work position No. 1 for adding reagent to the inner ring is located at the cup position No. 207; the work position No. 2 for adding reagent to the outer ring is located at the cup position No. 82, so the work position No. 2 for adding reagent to the inner ring is located at the cup position No.
226.
4. The analyzer according to claim 3, characterized in that The outer ring photoelectric collection workstation is located between the No. 5 cup position and the No. 6 cup position, and the inner ring photoelectric collection workstation is located between the No. 2 cup position and the No. 3 cup position; And / or, the outer ring sample adding working position is located at cup position No. 166, and the inner ring sample adding working position is located at cup position No. 163; And / or, the outer circle sample stirring and mixing work position is located at cup position No. 167, and the inner circle sample stirring and mixing work position is located at cup position No. 114; And / or, the outer ring sample adding working position is located at cup position No. 166, and the inner ring sample adding working position is located at cup position No. 163; And / or, the outer circle reagent stirring and mixing work position is located at cup position No. 33, and the inner circle reagent stirring and mixing work position is located at cup position No. 30; And / or, the outer circle reaction cup multi-stage cleaning workstations are located at cup positions 4 to 13, and the inner circle reaction cup multi-stage cleaning workstations are located at cup positions 1 to 10.
5. The analyzer according to any one of claims 1 to 4, characterized in that The analyzer further comprises a first reagent disk assembly arranged on the frame, the first reagent disk assembly comprises a first reagent disk inner ring loaded with reagent bottles and a first reagent disk outer ring, the first reagent disk outer ring is sleeved on the first reagent disk inner ring, and the first reagent disk inner ring and the first reagent disk outer ring can rotate independently of each other, the reagent bottle of the first reagent disk outer ring is filled with a first reagent, and the reagent bottle of the first reagent disk inner ring is filled with a second reagent; the first reagent needle assembly comprises a first inner reagent needle and a first outer reagent needle; the first outer reagent needle is arranged on the frame and can move relative to the frame, and is used to absorb the first reagent in the reagent bottle of the first reagent disk outer ring and transfer it to the reaction cup of the reagent adding work position No. 1 of the outer ring; the first inner reagent needle is arranged on the frame and can move relative to the frame, and is used to absorb the second reagent in the reagent bottle of the first reagent disk inner ring and transfer it to the reaction cup of the reagent adding work position No. 2 of the outer ring; Alternatively, the analyzer further comprises a first reagent tray assembly disposed on the frame, the first reagent tray assembly comprising a first reagent tray inner ring loaded with reagent bottles and a first reagent tray outer ring, the first reagent tray outer ring being sleeved on the first reagent tray inner ring, and the first reagent tray inner ring and the first reagent tray outer ring being able to rotate independently of each other, the reagent bottles of the first reagent tray outer ring being filled with a second reagent, and the reagent bottles of the first reagent tray inner ring being filled with a first reagent; the first reagent needle assembly comprising a first inner reagent needle and a first outer reagent needle; the first outer reagent needle being disposed on the frame and being able to move relative to the frame, and being used to absorb the second reagent in the reagent bottle of the outer ring of the first reagent tray and transfer it to a reaction cup at the reagent adding work position No. 2 of the outer ring; the first inner reagent needle being disposed on the frame and being able to move relative to the frame, and being used to absorb the first reagent in the reagent bottle of the inner ring of the first reagent tray and transfer it to a reaction cup at the reagent adding work position No. 1 of the outer ring.
6. The analyzer according to claim 5, characterized in that The analyzer further comprises a second reagent disk assembly arranged on the frame, the second reagent disk assembly comprises a second reagent disk inner ring loaded with reagent bottles and a second reagent disk outer ring, the second reagent disk outer ring is sleeved on the second reagent disk inner ring, and the second reagent disk inner ring and the second reagent disk outer ring can rotate independently of each other, the reagent bottle of the second reagent disk outer ring is filled with a first reagent, and the reagent bottle of the second reagent disk inner ring is filled with a second reagent; the second reagent needle assembly comprises a second inner reagent needle and a second outer reagent needle; the second outer reagent needle is arranged on the frame and can move relative to the frame, and is used to absorb the first reagent in the reagent bottle of the second reagent disk outer ring and transfer it to the reaction cup of the reagent No. 1 working position of the reaction disk inner ring, the second inner reagent needle is arranged on the frame and can move relative to the frame, and is used to absorb the second reagent in the reagent bottle of the second reagent disk inner ring and transfer it to the reaction cup of the reagent No. 2 working position of the reaction disk inner ring; Alternatively, the analyzer further comprises a second reagent tray assembly disposed on the frame, the second reagent tray assembly comprising a second reagent tray inner ring loaded with reagent bottles and a second reagent tray outer ring, the second reagent tray outer ring being sleeved on the second reagent tray inner ring, and the second reagent tray inner ring and the second reagent tray outer ring being able to rotate independently of each other, the reagent bottles of the second reagent tray outer ring being filled with a second reagent, and the reagent bottles of the second reagent tray inner ring being filled with a first reagent; the second reagent needle assembly comprising a second inner reagent needle and a second outer reagent needle; the second outer reagent needle being disposed on the frame and being able to move relative to the frame, and being used to absorb the second reagent in the reagent bottle of the outer ring of the second reagent tray and transfer it to a reaction cup at a reagent No. 2 working position of the inner ring of the reaction tray, the second inner reagent needle being disposed on the frame and being able to move relative to the frame, and being used to absorb the first reagent in the reagent bottle of the inner ring of the second reagent tray and transfer it to a reaction cup at a reagent No. 1 working position of the inner ring of the reaction tray.
7. The analyzer according to claim 6, characterized in that The first reagent disc assembly and the second reagent disc assembly are spaced apart from each other and are respectively located on two sides of the reaction disc; and / or, the motion trajectory of the first internal reagent needle does not intersect with the motion trajectory of the first external reagent needle; And / or, the motion trajectory of the second internal reagent needle does not intersect with the motion trajectory of the second external reagent needle.
8. The analyzer according to claim 6, characterized in that The first reagent needle assembly and the second reagent needle assembly can be mounted to the frame via linear guides and / or rotary rocker arms to achieve movement of the first reagent needle assembly and the second reagent needle assembly relative to the frame.
9. The analyzer according to claim 8, characterized in that The rotating rocker arm includes a first rocker arm assembly and a second rocker arm assembly which are arranged on the frame and whose motion trajectories do not interfere with each other. The first rocker arm assembly is arranged between the reaction disk and the first reagent disk assembly, and the second rocker arm assembly is arranged between the reaction disk and the second reagent disk assembly. The first rocker arm assembly includes a first inner rocker arm and a first outer rocker arm which are arranged on the frame and whose motion trajectories do not interfere with each other. The first inner rocker arm is connected to the first inner reagent needle and is used to drive the first inner reagent needle to move, and the first outer rocker arm is connected to the first outer reagent needle and is used to drive the first outer reagent needle to move. The second rocker arm assembly includes a second inner rocker arm and a second outer rocker arm which are arranged on the frame and whose motion trajectories do not interfere with each other. The second inner rocker arm is connected to the second inner reagent needle and is used to drive the second inner reagent needle to move, and the second outer rocker arm is connected to the second outer reagent needle and is used to drive the second outer reagent needle to move.
10. The analyzer according to any one of claims 1 to 4, characterized in that The inner ring of the reaction disk and the outer ring of the reaction disk can rotate independently of each other; And / or, the analyzer further comprises a photometer, a cleaning mechanism, a sample stirring assembly and a reagent stirring assembly which are arranged on the frame and distributed around the reaction disk; the photometer can respectively perform photoelectric data acquisition on the reaction cups on the outer ring photoelectric acquisition workstation and the inner ring photoelectric acquisition workstation to obtain the test reaction data in the reaction cup; the cleaning mechanism can perform multi-stage cleaning on the reaction cups on the outer ring reaction cup multi-stage cleaning workstation and the inner ring reaction cup multi-stage cleaning workstation; the sample stirring assembly can perform sample stirring and mixing actions on the reaction cups on the outer ring sample stirring and mixing workstation and the inner ring sample stirring and mixing workstation to mix the first reagent and the sample in the reaction cup to form a reaction liquid; the reagent stirring assembly can perform reagent stirring and mixing actions on the reaction cups on the outer ring reagent stirring and mixing workstation and the inner ring reagent stirring and mixing workstation to mix the second reagent in the reaction cup and the reaction liquid; And / or, the analyzer also includes a track and a sample needle assembly, the track is arranged on the frame, and the sample needle assembly can be installed on the frame by a linear guide and / or a rotating rocker arm to realize the movement of the sample needle assembly relative to the frame; the sample needle assembly is arranged between the track and the reaction disk, and the sample needle assembly includes a first sample needle and a second sample needle which are arranged on the frame and whose movement trajectories do not interfere with each other, the first sample needle is used to absorb the sample on the track and transfer it to the reaction cup of the inner circle sample working position of the reaction disk, and the second sample needle is used to absorb the sample on the track and transfer it to the reaction cup of the outer circle sample working position.