Traditional Chinese medicine composition for treating delayed absorption of qi-yin deficiency and lung collateral obstruction type pneumonia, preparation and application

Abstract

The invention discloses a traditional Chinese medicine composition for treating delayed absorption of qi-yin deficiency and lung collateral obstruction type pneumonia, a preparation and application. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 10 to 15g of radix pseudostellariae, 10 to 15g of radix asparagi, 6 to 10g of cortex mori radicis, 6 to 10g of radix scutellariae, 6 to 10g of radix platycodonis, 6 to 10g of exocarpium citri grandis, 6 to 10g of bulbus fritillariae thunbergii, 10 to 15g of pericarpium trichosanthis, 10 to 15g of spica prunellae, 15 to 30g of raw oyster shell, 6 to 10g of earthworm, 10 to 15g of radix salviae miltiorrhizae, 6 to 10g of rhizoma curcumae and 6 to 10g of raw liquorice root. The traditional Chinese medicine composition is suitable for delayed absorption of pneumonia caused by deficiency of both qi and yin and obstruction of lung collaterals, and also can be used for treating deficiency-heat syndrome and deficiency-cold syndrome on the basis of the formula, so that the aim of treating due to symptoms is fulfilled. The prescription is used for treating both symptoms and root causes of patients with deficiency of both qi and yin, internal stagnation of phlegm and blood stasis and lung collateral obstruction in delayed absorption of pneumonia on the basis of the basic treatment principles of tonifying lung and yin, reducing phlegm and softening hard mass, and promoting blood circulation to remove meridian obstruction. Clinical research finds that the pharmaceutical composition can improve clinical symptoms of patients with delayed absorption of pneumonia and promote inflammatory absorption, and is relatively safe.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and specifically relates to a traditional Chinese medicine composition, preparation and application for treating delayed absorption of qi and yin deficiency and lung collateral obstruction type pneumonia. Background Art

[0002] Clinically, some patients with pneumonia or severe pneumonia have improved their clinical symptoms after treatment, but the pulmonary infiltration shadows have not been completely absorbed. Chest CT scans after 2 weeks of treatment show that the lesion absorption is <50%, or it has not been completely absorbed or the lesions have increased after 4 weeks. This type of pneumonia is called delayed absorption of pulmonary inflammation. Delayed absorption of pneumonia is a new difficulty that needs to be solved in the diagnosis and treatment of community-acquired pneumonia. It is affected by many factors such as the host, etiology, and diagnosis and treatment methods. At present, modern medicine has no targeted and effective treatment for delayed absorption of pneumonia, and emphasizes that a review every 4-6 weeks is sufficient. With the deepening of traditional Chinese medicine's understanding of delayed absorption of pneumonia and related clinical research, it has gradually provided more basis for the clinical diagnosis and treatment of the disease.

[0003] Delayed absorption of pneumonia is a concept in modern medicine and does not have a specific TCM disease name. Through clinical observation, we believe that delayed absorption of pneumonia is consistent with the characteristics of lung system network disease in terms of etiology, course of disease, location of disease, and disease characteristics, and can be classified as a syndrome of lung system network disease: ① First, in terms of etiology, the causes of community-acquired pneumonia mainly include exogenous evil invading the lung and weak vital energy. Pathological products such as phlegm, dampness, and blood stasis are easily produced during the course of the disease. Long-term illness will damage the qi and yin of the lung, and cause deficiency due to excess, or a mixture of deficiency and excess. The causes of delayed absorption of pneumonia are nothing more than exogenous infection and internal injury; ② Secondly, in terms of the course of disease, the course of delayed absorption of pneumonia patients ranges from more than two weeks to four weeks or even longer, and the course is generally longer; ③ Furthermore, in terms of the location of the disease, delayed absorption of pneumonia occurs in the lung parenchyma and interstitium, while the lung The collaterals are scattered in the lungs and the lung system, and are composed of qi collaterals and blood collaterals. After they are separated from the lung meridian, they branch out layer by layer, forming a network system composed of branch collaterals at all levels, such as collaterals from branch collaterals to sun collaterals, which are similar to the bronchial tree and pulmonary microcirculation. The location of delayed absorption of pneumonia is undoubtedly in the collateral system of the lungs; ④Finally, in terms of disease characteristics, the biggest feature of delayed absorption of pneumonia is that after treatment, the parenchyma and interstitium of some lungs still show patchy high-density shadows on imaging, characterized by "stagnation". By analogy, it indicates that the disease has obstruction of the lung collaterals and internal blood stasis; and clinical studies have found that compared with standard inflammatory markers, D-dimers have a better correlation with the severity of pneumonia, which also suggests that patients with delayed absorption of pneumonia have local blood microcirculation disorders, which is consistent with the disease characteristics of pulmonary system collateral diseases. In summary, the theory of lung network disease is the theoretical core of understanding and studying delayed absorption of pneumonia; the onset of this disease is in the lung network, and deficiency, phlegm and blood stasis are the key to the pathogenesis; deficiency of lung, spleen and kidney qi, yin deficiency or deficiency of qi and yin, yin and yang deficiency are the fundamental deficiency, phlegm turbidity and blood stasis are the superficial excess, and deficiency of the body and excess of evil influence each other, and phlegm and blood stasis eventually lead to obstruction of lung network. In summary, delayed absorption of pneumonia is always a mixture of deficiency and excess, and the disease is located in the lung network. The basic pathogenesis is: deficiency of qi and yin, internal phlegm and blood stasis, and obstruction of lung network. The treatment principle and method are mainly to replenish qi and nourish yin, resolve phlegm and soften hard masses, and activate blood circulation and dredge the network.

[0004] The present invention aims to provide a traditional Chinese medicine composition for treating delayed absorption of qi and yin deficiency and lung network obstruction type pneumonia based on the theory of lung network disease. Summary of the invention

[0005] The first purpose of the present invention is to provide a Chinese medicine composition for treating Qi and Yin deficiency and delayed absorption of lung collateral obstruction type pneumonia, and the second purpose is to provide a preparation dosage form and application of the Chinese medicine composition.

[0006] The first object of the present invention is achieved in this way. A Chinese medicine composition for treating delayed absorption of qi and yin deficiency and lung collateral obstruction type pneumonia is composed of 10-15g of Pseudostellariae Radix, 10-15g of Asparagus cochinchinensis, 6-10g of Morus alba bark, 6-10g of Scutellaria baicalensis, 6-10g of Platycodon grandiflorum, 6-10g of Citrus aurantium, 6-10g of Fritillaria thunbergii, 10-15g of Trichosanthes peel, 10-15g of Prunella vulgaris, 15-30g of raw oyster, 6-10g of Pheretima, 10-15g of Salvia miltiorrhiza, 6-10g of Curcuma zedoaria, and 6-10g of raw liquorice.

[0007] The second purpose is achieved in that the pharmaceutical preparation of the traditional Chinese medicine composition for treating delayed absorption of pneumonia caused by deficiency of both qi and yin and obstruction of lung collaterals is prepared by adding medically acceptable excipients to the formula of the traditional Chinese medicine composition to form any one of decoctions, granules, pills, tablets, capsules, ointments, syrups, powders and granules.

[0008] The Chinese medicine composition is used in the preparation of medicines for treating delayed absorption of qi and yin deficiency and lung collateral obstruction type pneumonia.

[0009] The inventors have found that although there is no specific TCM name for delayed absorption of pneumonia, it can be understood from the theory of lung network disease. The theory of network disease originated from the Yellow Emperor's Classic of Internal Medicine, and was founded and developed in Treatise on Febrile and Miscellaneous Diseases. Ye Tianshi inherited and developed it on the basis of his predecessors, making the network disease theory system initially formed. After continuous supplementation and improvement by later generations of doctors, the network disease theory has become increasingly rich. In summary, the network disease theory mainly studies the network disease theory and uses the network disease theory to guide clinical practice, explore the occurrence and development of diseases, clinical diagnosis and treatment, and prescriptions. Lung network disease is a type of disease with poor lung network operation, qi stagnation and blood stasis blocking the lung network, phlegm and blood stasis coagulating the lung network, and lung network malnutrition and damage as the main pathological changes; the pathogenesis is characterized by easy stagnation and blood stasis, easy entry and difficult exit. Specifically, lung system collateral diseases have the following main characteristics: ① In terms of its causes, they mainly include invasion of exogenous evil, internal injuries caused by diet and emotions, long-term illness and fatigue, etc.; ② In terms of its course of disease, the course of disease is generally long, that is, "long-term illness enters the collaterals"; ③ In terms of its location, it should be in the collateral system of the lung, including pulmonary blood circulation, gas exchange system, lymphatic circulation and interstitial immune system; ④ In terms of its characteristics, it is characterized by collateral stasis.

[0010] Through clinical observation, we believe that delayed absorption of pneumonia is consistent with the characteristics of lung network disease in terms of etiology, course of disease, location of disease, and disease characteristics, and can be classified as a disease syndrome of lung network disease. The theory of lung network disease is the theoretical core of understanding and studying delayed absorption of pneumonia; when this disease occurs, the disease is located in the lung network, and deficiency, phlegm, and blood stasis are the key to the pathogenesis; deficiency of qi, yin, or deficiency of qi and yin, yin and yang are the fundamental deficiency, and phlegm turbidity and blood stasis are the superficial excess. The deficiency of the body and the excess of evil influence each other, and the phlegm and blood stasis eventually lead to the obstruction of the lung network. In summary, the delayed absorption of pneumonia is always a mixture of deficiency and excess, and the disease is located in the lung network. The basic pathogenesis is: deficiency of qi and yin, internal phlegm and blood stasis, and obstruction of the lung network. The treatment principles and methods are mainly to replenish qi and nourish yin, resolve phlegm and soften hard masses, and activate blood circulation and dredge the network.

[0011] Aiming at the etiology and pathogenesis of delayed absorption of pneumonia, the present invention provides a Chinese medicine prescription with the effects of invigorating qi and nourishing yin, resolving phlegm and unblocking collaterals, i.e., "Yifei Tongluo Fang" for treating delayed absorption of pneumonia in clinical practice. In this prescription, Radix Pseudostellariae Radix and Asparagus cochinchinensis invigorate qi and nourish yin, raw oyster, earthworm, salvia miltiorrhiza, and Curcuma zedoariae soften and disperse nodules, break blood stasis and dredge collaterals, and the six flavors are the main medicines; Morus alba and Scutellaria baicalensis clear and discharge deficiency heat, and Citrus aurantium, Fritillaria thunbergii, and Herba Prunellae resolve phlegm and disperse nodules, and nourish yang and yin, which are all ministerial medicines; Platycodon grandiflorum and Fructus Trichosanthis peel focus on dispersing and relieving chest tightness and regulating qi, which can enhance the functions of resolving phlegm, dispersing nodules, and unblocking collaterals, and are adjuvants; raw licorice harmonizes all medicines, and has both functions and adjuvants. The whole prescription combination aims at the etiology and pathogenesis of delayed absorption of pneumonia, invigorates the lungs and nourishes yin, resolves phlegm and softens nodules, activates blood circulation and dredges collaterals, uses several methods together, treats both the symptoms and the root causes, and the medicine and symptoms are consistent. During treatment, the Yifei Tongluo prescription is used as the main prescription, and the dosage can be adjusted according to the symptoms. If the symptoms include hot flashes and night sweats, add Zhimu, Phellodendron, Rehmannia glutinosa, Schisandra chinensis, etc. to clear away heat and nourish yin fluid; if the patient has fatigue, tiredness, and poor appetite, Shenling Baizhu powder can be used to invigorate qi and strengthen the spleen; if the patient has palpitations and insomnia, add Suanzaoren, Torreya grandis, Polygala tenuifolia, Raw Dragon Bone, etc. to nourish the heart and calm the mind; if the patient has obvious signs of blood stasis such as purple tongue or ecchymosis or petechiae, and thin or wiry pulse, add Trillium, Prunus persica, Safflower, Hedyotis diffusa, etc. to promote blood circulation, remove blood stasis, and dissipate symptoms.

[0012] The Chinese medicine composition of the present invention has both the treatment of the symptoms and the root cause for the treatment of delayed absorption of pneumonia caused by deficiency of both qi and yin, and the double supplementation of qi and yin. The prescription of the present invention is added or subtracted on the basis of the prescription to achieve the purpose of treating the symptoms according to the symptoms. The prescription of the present invention is aimed at delayed absorption of pneumonia caused by deficiency of both qi and yin, internal stagnation of phlegm and blood stasis, and obstruction of lung collaterals, with the basic treatment principles of nourishing the lungs and nourishing yin, resolving phlegm and softening hard masses, and promoting blood circulation and unblocking collaterals. It has both elimination and supplementation, invigorating qi and nourishing yin without stagnation, unblocking collaterals and expelling evil without hurting the body, treating the symptoms and the root cause, and giving full play to the synergistic effect between the tastes of the medicine. The present invention is well matched, the medication is plain and clear, the medicine and the evidence are consistent, the clinical applicability is strong, and the acceptance is high. Clinical studies have shown that the Chinese medicine composition of the present invention can improve patient symptoms, promote inflammation absorption, shorten the course of disease, and the chest CT score is reduced compared with the control group after 28 days of treatment with the Chinese medicine composition of the present invention, and there is a statistical difference. DETAILED DESCRIPTION

[0013] The present invention is further described below in conjunction with the embodiments, but the present invention is not limited in any way. Any changes or substitutions made based on the technical teachings of the present invention belong to the protection scope of the present invention.

[0014] The invention discloses a traditional Chinese medicine composition for treating delayed absorption of qi-yin deficiency and lung-column obstruction type pneumonia. The traditional Chinese medicine composition comprises, by weight, 10-15g of Pseudostellariae Radix, 10-15g of Asparagus cochinchinensis, 6-10g of Morus alba bark, 6-10g of Scutellaria baicalensis, 6-10g of Platycodon grandiflorum, 6-10g of Citrus aurantium, 6-10g of Fritillaria thunbergii, 10-15g of Trichosanthes peel, 10-15g of Prunella vulgaris, 15-30g of raw oyster, 6-10g of Pheretima, 10-15g of Salvia miltiorrhiza, 6-10g of Curcuma zedoariae and 6-10g of raw liquorice.

[0015] The Chinese medicine composition is added with 6-10g of Radix Rehmanniae, 5-10g of Rhizoma Anemarrhenae, 6-10g of Phellodendron chinense and 6-10g of Radix Rehmanniae, which is suitable for both qi and yin deficiency and deficiency-heat syndrome to achieve the effects of nourishing yin and clearing heat. The combination of the two can enhance the effects of invigorating qi and nourishing yin, nourishing yin and clearing heat, moistening the lungs and relieving cough.

[0016] The Chinese medicine composition is added with 6-10g of Psoralea corylifolia, 6-9g of dried ginger, 3-6g of cinnamon bark, and 5-10g of gecko powder, which is suitable for deficiency of both qi and yin, and deficiency-cold syndrome, so as to achieve the effect of warming and tonifying the lungs and kidneys. The two are used together to strengthen the power of invigorating qi and nourishing yin, warming and transforming phlegm and fluid, and tonifying the kidney and absorbing qi.

[0017] The present invention also provides a pharmaceutical preparation based on the traditional Chinese medicine composition for treating delayed absorption of qi and yin deficiency and lung collateral obstruction type pneumonia. Medically acceptable excipients are added to the traditional Chinese medicine composition formula to be prepared into any one of decoctions, granules, pills, tablets, capsules, ointments, syrups, powders and granules.

[0018] The granules are prepared by the following steps: (1) Decoction: Add water to each ingredient of the formula at a weight ratio of 1:6-10 and decoct for 1-3 times, each time for 30-60 minutes, and combine the decoctions; (2) Concentration: The decoction is concentrated into a thick paste at 50-75°C and a vacuum degree of -0.02-0.06 MPa. The density of the thick paste at 50°C is 1.20 g / ml. (3) Drying: Dry the thick paste at 60~70℃ and -0.02~-0.06MPa vacuum to form a dry paste for later use; (4) The dry paste is crushed and passed through a 100-mesh sieve to obtain a mixed dry paste powder. 10 to 30 g of granulation excipients are added and mixed evenly. An appropriate amount of 70% to 90% ethanol is added and wet granulated. After drying, granules are obtained.

[0019] The granulation auxiliary material is one or a combination of dextrin, maltodextrin or sucrose.

[0020] The pills are prepared by the following steps: (1) Decoction: weigh each medicinal ingredient according to the formula, add water at a weight ratio of 1:6-10, and decoct for 1-3 times, each time for 35-45 minutes, and combine the decoctions; (2) Concentration: The decoction is concentrated into a thick paste at 50-75°C and a vacuum degree of -0.02-0.06 MPa. The density of the thick paste is 1.20-1.35 g / ml at 50-60°C. (3) Drying: Dry the thick paste at 50~75℃ and -0.02~0.06MPa vacuum to form a dry paste for later use; (4) Crush the dry paste and pass it through a 100-mesh sieve to obtain a mixed dry paste powder. Then, mix it with water or an ethanol aqueous solution with a concentration of 30% or less to make pills.

[0021] The present invention further provides the use of the traditional Chinese medicine composition in the preparation of a medicine for treating delayed absorption of qi and yin deficiency and lung collateral obstruction type pneumonia.

[0022] Example 1 Prescription: Pseudostellariae Radix 10g, Asparagus cochinchinensis 10g, Morus alba bark 15g, Scutellariae 10g, Platycodon grandiflorum 6g, Citrus aurantium 10g, Fritillaria thunbergii 10g, Trichosanthes peel 15g, Prunella vulgaris 10g, raw oyster 30g, Pheretima lumbarum 10g, Salvia miltiorrhiza 15g, Curcuma 10g, and raw liquorice 5g.

[0023] Add water to each ingredient in the prescription at a weight ratio of 1:8, and boil for 3 times, each time for 45 minutes. Combine the decoctions to obtain a decoction.

[0024] Example 2 Prescription: Pseudostellariae Radix 10g, Asparagus cochinchinensis 10g, Morus alba bark 6g, Scutellariae 10g, Platycodon grandiflorum 6g, Citrus aurantium 10g, Fritillaria thunbergii 10g, Trichosanthes peel 15g, Prunella vulgaris 10g, raw oyster 30g, Pheretima lumbarum 10g, Salvia miltiorrhiza 10g, Curcuma 10g, and raw liquorice 6g.

[0025] Add water to each ingredient in the formula at a weight ratio of 1:10, and boil for three times, each time for 60 minutes. Combine the decoctions to obtain a decoction.

[0026] Example 3 Prescription: Pseudostellariae Radix 10g, Asparagus cochinchinensis 10g, Morus alba bark 10g, Scutellariae 10g, Platycodon grandiflorum 6g, Citrus aurantium 10g, Fritillaria thunbergii 10g, Trichosanthes peel 15g, Prunella vulgaris 10g, raw oyster 30g, Pheretima lumbarum 10g, Salvia miltiorrhiza 15g, Curcuma 10g, and raw liquorice 6g.

[0027] Add water to each medicinal ingredient of the formula at a weight ratio of 1:6, and boil for 3 times, each time for 30 to 60 minutes, and combine the decoctions; concentrate the resulting decoction at 75°C and a vacuum degree of -0.02~0.06MPa to form a thick paste, the density of which is 1.35g / ml at 60°C; dry the thick paste at 60°C and a vacuum degree of -0.02~-0.06MPa to form a dry paste, crush the dry paste and pass it through a 100-mesh sieve to obtain a mixed dry paste powder, add 10g of dextrin and mix well, add an appropriate amount of 70% ethanol, wet granulate, and obtain granules after drying.

[0028] Example 4 Prescription: Pseudostellariae Radix 15g, Asparagus cochinchinensis 10g, Morus alba bark 10g, Scutellariae 10g, Platycodon grandiflorum 6g, Citrus aurantium 10g, Fritillaria thunbergii 10g, Trichosanthes peel 15g, Prunella vulgaris 10g, Raw oyster 30g, Pheretima lumbar disc 6g, Salvia miltiorrhiza 10g, Curcuma 10g, Raw Licorice 6g.

[0029] Weigh each medicinal ingredient in the prescription according to the prescription amount, add water at a weight ratio of 1:8 for decocting twice, each time for 60 minutes, and combine the decoctions; concentrate the obtained decoction at 75°C and a vacuum degree of -0.02~0.06MPa to form a thick paste, the density of which is 1.20g / ml at 50°C; dry the thick paste at 75°C and a vacuum degree of -0.02~0.06MPa to form a dry paste, crush the dry paste and pass it through a 100-mesh sieve to obtain a mixed dry paste powder, and make pills with water.

[0030] Example 5 Prescription: Pseudostellariae Radix 10g, Asparagus cochinchinensis 10g, Morus alba bark 6g, Scutellariae 10g, Platycodon grandiflorum 6g, Citrus aurantium 10g, Fritillaria thunbergii 10g, Trichosanthes peel 15g, Prunella vulgaris 10g, raw oyster 30g, Pheretima lumbarum 10g, Salvia miltiorrhiza 10g, Curcuma 10g, raw liquorice 6g, Rehmannia root bark 10g, Rhizoma Anemarrhenae 10g, Phellodendron chinense 10g, and Rehmannia root 10g.

[0031] Add water to each ingredient of the formula according to the weight ratio of 1:10, and decoct for 3 times, each time for 45 minutes, and combine the decoctions; concentrate the decoctions at 65℃, at -0.02~0.06MPa vacuum to a thick paste, the density of which is 1.35g / ml at 60℃; dry the thick paste at 65℃, at -0.02~-0.06MPa vacuum to a dry paste, crush the dry paste and pass through a 100-mesh sieve to obtain a mixed dry paste powder, add 30g maltodextrin and mix well, add an appropriate amount of 90% ethanol, wet granulate, and dry to obtain granules. This prescription is suitable for deficiency of both qi and yin, and deficiency-heat syndrome, to achieve the effect of nourishing yin and clearing heat. The combination of the two can enhance the power of nourishing qi and yin, nourishing yin and clearing heat, moistening the lungs and relieving cough.

[0032] Example 6 Prescription: Pseudostellariae Radix 10g, Asparagus cochinchinensis 10g, Morus alba bark 10g, Scutellariae 10g, Platycodon grandiflorum 6g, Citrus aurantium 10g, Fritillaria thunbergii 10g, Trichosanthes peel 15g, Prunella vulgaris 10g, raw oyster 30g, Pheretima lumbarum 10g, Salvia miltiorrhiza 10g, Curcuma 10g, raw liquorice 6g, Rehmannia root bark 10g, Rhizoma Anemarrhenae 5g, Phellodendron chinense 10g, and raw Rehmannia root 6g.

[0033] Weigh each medicinal ingredient in the formula according to the formula amount, add water and decoct three times at a weight ratio of 1:9, each time for 45 minutes, and combine the decoctions; concentrate the decoctions at 70°C and -0.02~0.06MPa vacuum to form a thick paste, the density of which is 1.35g / ml at 60°C; dry the thick paste at 65°C and -0.02~0.06MPa vacuum to form a dry paste, crush the dry paste and pass through a 100-mesh sieve to obtain a mixed dry paste powder, and use 30% ethanol to make pills. This prescription is suitable for both qi and yin deficiency, and deficiency-heat syndrome, in order to achieve the effect of nourishing yin and clearing heat. The combination of the two can enhance the power of nourishing qi and yin, nourishing yin and clearing heat, moistening the lungs and relieving cough.

[0034] Example 7 Prescription: Pseudostellariae Radix 10g, Asparagus cochinchinensis 10g, Morus alba bark 6g, Scutellariae 10g, Platycodon grandiflorum 6g, Citrus aurantium 10g, Fritillaria thunbergii 10g, Trichosanthes peel 15g, Prunella vulgaris 10g, raw oyster 30g, Pheretima lumbarum 10g, Salvia miltiorrhiza 10g, Curcuma 10g, raw licorice 6g, Psoralea corylifolia 10g, dried ginger 6g, cinnamon bark 6g, and Gecko powder 10g.

[0035] Add water to each ingredient of the formula according to the weight ratio of 1:10, and decoct for 3 times, each time for 60 minutes, and combine the decoctions; concentrate the decoctions at 75℃, at -0.02~0.06MPa vacuum to a thick paste, the density of which is 1.35g / ml at 60℃; dry the thick paste at 72℃, at -0.02~-0.06MPa vacuum to a dry paste, crush the dry paste and pass through a 100-mesh sieve to obtain a mixed dry paste powder, add 20g of sucrose and mix well, add an appropriate amount of 80% ethanol, wet granulate, and dry to obtain granules. This prescription is suitable for deficiency of both qi and yin, and deficiency-cold syndrome, to achieve the effect of warming and tonifying the lungs and kidneys. The two are used together to strengthen the power of replenishing qi and nourishing yin, warming and transforming phlegm and fluid, and tonifying the kidney and absorbing qi.

[0036] Example 8 Prescription: Pseudostellariae Radix 15g, Asparagus cochinchinensis 10g, Morus alba bark 6g, Scutellariae 10g, Platycodon grandiflorum 6g, Citrus aurantium 6g, Fritillaria thunbergii 10g, Trichosanthes peel 15g, Prunella vulgaris 10g, raw oyster 30g, Pheretima lumbarum 10g, Salvia miltiorrhiza 15g, Curcuma 10g, raw Licorice root 6g, Psoralea corylifolia 6g, dried ginger 6g, cinnamon bark 6g, Gecko powder 5g.

[0037] Weigh each medicinal ingredient in the formula according to the formula amount, add water and decoct twice at a weight ratio of 1:10, each time for 60 minutes, and combine the decoctions; concentrate the decoctions at 70℃, -0.02~0.06MPa vacuum to form a thick paste, the density of which is 1.35g / ml at 60℃; dry the thick paste at 70℃, -0.02~0.06MPa vacuum to form a dry paste, crush the dry paste and pass through a 100-mesh sieve to obtain a mixed dry paste powder, and use 30% ethanol to make pills. This prescription is suitable for deficiency of both qi and yin, and deficiency-cold syndrome, to achieve the effect of warming and tonifying the lungs and kidneys. The two are used together to strengthen the power of replenishing qi and nourishing yin, warming and transforming phlegm and dampness, and tonifying the kidney and absorbing qi.

[0038] Clinical Cases Li, female, 56 years old, farmer, date of consultation: November 17, 2017.

[0039] Chief complaint: fever for more than half a month. The patient developed fever and chills after catching a cold more than half a month ago. The specific body temperature was not measured. The patient had nasal congestion and runny nose, no obvious chest tightness and pain, no sore throat, no abdominal pain and diarrhea. He took Tylenol and cephalosporin drugs on his own, but the symptoms did not improve significantly. On November 15, the blood routine test at the local health center showed: WBC: 11.14×10 9 / L, N%: 83.1%, L%: 10.5%; after receiving cephalosporin infusion treatment, the symptoms still did not show significant improvement. Today, he was admitted to the outpatient clinic and is now admitted to the ward for further systematic diagnosis and treatment. The symptoms at admission were: fever, chills, cough, little sputum, fatigue, no obvious chest tightness and pain, no sore throat, no abdominal pain and diarrhea, no rash, no obvious joint pain, poor bowel movements, normal urination, and poor sleep. Physical examination at admission: symmetrical chest without deformity, symmetrical bilateral respiratory movements, clear percussion of bilateral lungs, low breath sounds in both lungs, and no obvious dry or wet rales. Red tongue with yellow fur and stringy pulse. Related examinations completed at admission: Chest CT (2017-11-17): infection of both lower lungs; multiple nodules in both lungs. CRP: 332.13mg / L, DD: 1.67mg / L. Western medicine diagnosis: community-acquired pneumonia; Chinese medicine diagnosis: wind-heat lung heat disease. In terms of treatment, according to the diagnosis and treatment standards, symptomatic treatment such as moxifloxacin combined with ceftriaxone for infection prevention, ambroxol for expectoration and fluid support was given. Five days later, the patient's body temperature returned to normal, and the symptoms of cough and sputum gradually eased. Chest CT was re-examined 2 weeks after anti-infection treatment (2017-11-30): The infection in both lower lungs was partially absorbed compared with the previous film (lesion absorption <50%); multiple nodules in both lungs. The patient's condition improved and was discharged to the outpatient clinic for oral Chinese medicine for continued treatment. Symptoms at discharge: The patient had no obvious cough and sputum, no fever, no nasal congestion and runny nose, no chest tightness or chest pain, less spirit, fatigue, poor appetite, occasional night sweats, dry mouth, basically normal bowel movements, and poor sleep. The tongue was pale and dark, with a slightly greasy yellow coating, and a thin and stringy pulse. Western medicine diagnosis: delayed absorption of pneumonia, Chinese medicine syndrome: Qi and Yin deficiency, lung collateral obstruction. The Chinese medicine is used to nourish the lungs and yin, resolve phlegm and soften hard masses, and activate blood circulation and dredge collaterals. The Chinese medicine composition of the present invention is added or subtracted. The specific prescription is as follows: 10g of Pseudostellariae Radix, 10g of Asparagus cochinchinensis, 10g of Schisandrae Chinensis, 15g of Poria, 15g of Morus alba, 10g of Fritillaria thunbergii, 10g of stir-fried Scutellariae baicalensis, 30g of raw oyster, 10g of Citrus aurantium, 6g of Platycodon grandiflorum, 15g of Trichosanthes peel, 10g of Prunella vulgaris, 30g of Coix seeds, 15g of Salvia miltiorrhiza, 10g of Curcuma zedoariae, and 5g of raw liquorice. 14 doses, decocted in water, 1 dose per day.

[0040] Follow-up on December 13, 2017: The patient looked natural, reported no obvious fatigue, dry mouth symptoms improved, and no night sweats. The tongue was pale red with thin yellow fur, and the pulse was stringy. The above prescription was reduced by Schisandra, Poria, and Coix Seed, and the Yifei Tongluo prescription was continued. The specific prescriptions and medicines are as follows: Pseudostellaria 10g, Asparagus 10g, Morus alba 15g, Fritillaria thunbergii 10g, Stir-fried Scutellaria 10g, Raw Oyster 30g, Citrus aurantium 10g, Platycodon 6g, Trichosanthes peel 15g, Prunella vulgaris 10g, Salvia miltiorrhiza 15g, Curcuma 10g, Raw Licorice 5g. 14 doses, decocted in water, 1 dose per day. Chest CT was re-examined in the outpatient clinic 2 weeks later (2017-12-28): The infection in both lower lungs was basically absorbed compared with the previous film (2017-11-30); multiple nodules were found in both lungs, and follow-up reexamination was recommended.

[0041] According to this case, the patient was admitted to the hospital for community-acquired pneumonia. According to the Western medical diagnosis and treatment standards, the imaging examination after 2 weeks of anti-infection treatment showed that the absorption of lung inflammation lesions was less than 50%, so the Western medical diagnosis was delayed absorption of pneumonia. The patient had obvious symptoms of spleen deficiency such as fatigue and weakness when he was admitted to the hospital. When he was discharged from the hospital, the main symptoms were fatigue, poor appetite, occasional night sweats, and dry mouth. In addition, he was old and had insufficient qi and yin. Combined with the pale and dark tongue, slightly greasy yellow fur, and thin and stringy pulse, it indicated that there was blood stasis in the collaterals. According to the four examinations, the TCM syndrome differentiation was qi and yin deficiency and lung collateral obstruction. Because the patient had obvious symptoms of spleen deficiency, the Yifei Tongluo Recipe was used as the basic recipe when formulating the prescription, and Shenling Baizhu San was used for addition and subtraction to achieve the function of strengthening the spleen and replenishing qi and cultivating the soil to produce gold. During the follow-up visit, the patient's symptoms of fatigue and weakness had been basically improved, so the prescription was removed from Poria cocos, Coix seed, Schisandra chinensis, etc., and the original prescription of Yifei Tongluo was taken orally. After taking Chinese medicine for another 2 weeks, the imaging examination showed that the pulmonary inflammatory lesions were basically absorbed, which preliminarily indicated the effectiveness of Yifei Tongluo prescription in treating delayed absorption of pneumonia.

[0042] The clinical efficacy test of the present invention is described in detail below: 1. Materials and methods 1.1 General Information The research subjects were patients with delayed absorption of community-acquired pneumonia who visited the outpatient clinic and ward of the Department of Respiratory Medicine of Suzhou Hospital of Traditional Chinese Medicine from 2016 to 2019 and cooperated with and completed the collection of case-related data. The patients with delayed absorption of pneumonia were randomly divided into a Chinese medicine group and a blank group: 33 cases in the Chinese medicine group and 30 cases in the blank group. There were 17 males and 16 females in the Chinese medicine group, aged 23-74 years old, with an average age of (42.09±13.76) years old; there were 16 males and 14 females in the blank group, aged 18-70 years old, with an average age of (41.27±14.06) years old; 16 cases in the Chinese medicine group had underlying diseases, and 12 cases in the blank group had underlying diseases, distributed in the respiratory, immune, circulatory, digestive, urinary, and nervous systems. The general data of the two groups did not show statistical differences (P>0.05) after comparison, and they were comparable.

[0043] 1.2 Inclusion criteria ① Meet the Western medical diagnostic criteria for community-acquired pneumonia; ② Meet the radiological criteria for delayed absorption of pneumonia: For patients diagnosed with pneumonia, chest CT scan after 2 weeks of treatment showed that the lesion absorption was less than 50%, or it was not completely absorbed or the lesions increased after 4 weeks; ③Age 18-75 years old; ④Have good compliance with treatment.

[0044] 1.2.1 Diagnostic criteria for community-acquired pneumonia Refer to the diagnostic criteria of the "Guidelines for the Diagnosis and Treatment of Community-Acquired Pneumonia" formulated by the Chinese Medical Association: ① New onset of cough and sputum, or worsening of existing respiratory disease symptoms, with the appearance of purulent sputum; with or without chest pain. ② Fever. ③ Signs of pulmonary consolidation and (or) moist rales. ④ WBC>10×109 / L or <4×109 / L, with or without nuclear left shift. ⑤ Chest X-ray examination shows flake-like, patchy infiltrative shadows or interstitial changes, with or without pleural effusion. Any one of the above 1-4 items plus item 5, and excludes tuberculosis, lung tumors, non-infectious interstitial lung diseases, pulmonary edema, atelectasis, pulmonary embolism, pulmonary eosinophil infiltration, pulmonary vascular inflammation, etc.

[0045] 1.2.2 TCM diagnostic criteria The diagnostic criteria for community-acquired pneumonia in traditional Chinese medicine were formulated with reference to the "Routine Diagnosis and Treatment of Diseases in Traditional Chinese Medicine" and the "Release of Clinical Pathways and Treatment Plans for 95 TCM Advantageous Diseases".

[0046] Diagnostic criteria for Qi and Yin deficiency syndrome in community-acquired pneumonia: Qi and Yin deficiency syndrome was formulated with reference to the "Routine Diagnosis and Treatment of Diseases in Traditional Chinese Medicine" and "Traditional Chinese Medicine Internal Medicine".

[0047] Main symptoms: (1) dry cough with little sputum; (2) shortness of breath, which worsens after activity and is progressive.

[0048] Secondary symptoms: (1) weak cough; (2) fatigue, shortness of breath; (3) spontaneous sweating, fear of wind; (4) dry mouth and thirst; (5) night sweats.

[0049] Tongue and pulse: The tongue is tender and red, with little or peeled coating, and the pulse is weak and thready.

[0050] The diagnosis can be made based on the above 2 main symptoms + 1 secondary symptom or 1 main symptom + 2 secondary symptoms.

[0051] 1.3 Exclusion criteria ① Pregnant or lactating women, or women who are preparing to become pregnant; ② Those who are allergic to the drug ingredients in this prescription, or have serious adverse events and complications; ③Combined with serious primary diseases such as cardiovascular, liver, kidney and hematopoietic system; ④Psychiatric patients; ⑤ Unable to cooperate with treatment and clinical observation, and poor compliance.

[0052] 1.4 Elimination criteria (1) After the trial, there are no recorded cases; (2) Those who use medication improperly during the trial.

[0053] 1.5 Termination test criteria (1) If intolerable adverse events occur, the study should be stopped; (2) According to the doctor's judgment, the patient's condition worsens or other conditions that affect the trial observation should be stopped (treat as an invalid case); (3) According to the doctor's judgment, it is difficult to evaluate the drug effect due to serious deviations in the implementation of the clinical trial protocol, such as poor compliance; (4) Subjects are unwilling to continue treatment and request to withdraw.

[0054] 1.6 Dropout criteria and treatment of dropout cases (1) Dropout criteria: Subjects who have been screened into the trial but whose treatment and observation periods have not met the study objectives due to some reasons The cases were judged as dropouts according to the standards of the program.

[0055] (2) Handling of dropout cases: a. When a subject drops out, the researcher should contact the subject as soon as possible to inquire about the reason and take appropriate measures, and continue to record the last medication time and observable indicators. b. Previous trial data of dropout cases should be kept on file.

[0056] 1.7 Research Methods 1.7.1 Treatment options Basic treatment: Provide good patient education, avoid contact with irritating odors, particulate dust and chemical reagents, and adjust work, rest and diet.

[0057] Patients with delayed pneumonia absorption were randomly divided into a Chinese medicine treatment group and a blank group. The Chinese medicine group took the Chinese medicine composition of the embodiment 1 of the present invention orally, and the ingredients were: 10g of Pseudostellariae Radix, 10g of Asparagus cochinchinensis, 15g of Morus alba, 10g of Scutellaria baicalensis, 6g of Platycodon grandiflorum, 10g of Citrus aurantium, 10g of Fritillaria thunbergii, 15g of Trichosanthes root, 10g of Prunella vulgaris, 30g of raw oyster, 10g of Pheretima chinensis, 15g of Salvia miltiorrhiza, 10g of Curcuma zedoaria, and 5g of raw Licorice. Decoction, one dose per day, 2 times a day, about 200mL each time. Re-examine once every two weeks, and adjust the medicine according to the patient's condition if necessary, and make detailed records; the blank group does not take medicine and re-examines once every two weeks. Both groups closely observe the condition. If the condition worsens, relevant symptomatic treatment is given immediately, and the experiment is withdrawn. The course of treatment and observation time are both 28 days. At the end of the course of treatment, the chest CT is reviewed, and the pneumonia chest CT absorption score is performed again according to the chest CT scoring method.

[0058] Concomitant treatment: For medications that must be continued for concurrent diseases, the name of the medication (or other treatment), dosage, number of uses, etc. must be recorded in the medical record for analysis and reporting in the summary.

[0059] 1.7.2 Observation indicators 1.7.2.1 TCM symptom score Refer to the "Guidelines for Clinical Research of New Chinese Medicines" issued by the State Administration of Traditional Chinese Medicine. Complete the TCM symptom score table before treatment, 2 weeks after treatment, and 28 days after treatment. (See Table 1) Table 1 TCM clinical symptom score table Note: Refer to the scoring method of the "Guidelines for Clinical Research of New Chinese Medicines" issued by the State Administration of Traditional Chinese Medicine. Scoring principle: The main symptoms are scored as "mild, moderate, and severe", and are scored as "3 points, 6 points, and 9 points" respectively; the secondary symptoms are scored as "mild, moderate, and severe", and are scored as "2 points, 4 points, and 6 points" respectively.

[0060] 1.7.2.2 Cough life quality score (LCQ) The Leicester Cough Questionnaire (LCQ) was evaluated before treatment, 2 weeks after treatment, and 28 days after treatment. LCQ is mainly used to evaluate the impact of cough on quality of life, reflect the efficacy of experimental cough treatment and the impact of cough on health. The "Guidelines for the Diagnosis and Treatment of Cough (2021)" recommends the use of the Chinese version of LCQ to evaluate cough-related quality of life.

[0061] 1.7.2.3 Blood routine white blood cell and C-reactive protein determination Blood routine test and C-reactive protein were measured before treatment, 2 weeks and 28 days after treatment.

[0062] 1.7.2.4 Pneumonia chest CT scoring The chest CT absorption score of pneumonia was performed according to the chest CT scoring method before treatment and 28 days after treatment. The morphology, distribution, and range of pulmonary lesions were evaluated semi-quantitatively by HRCT quantitative analysis method, and the chest CT absorption score of pneumonia was evaluated and recorded at the time of enrollment and on days 0 and 28 after treatment.

[0063] The chest CT score is determined by two radiologists with the rank of associate chief physician or above who analyze the imaging data and discuss together. The chest CT score is performed by the HRCT quantitative analysis method, and the morphology, distribution, and range of the lesions in the lungs are evaluated semi-quantitatively, which more objectively reflects the damage to the lung tissue. The signs described include: ground-glass density shadows, consolidation shadows, nodular shadows, and interstitial damage. The two lungs are divided into three parts: upper, middle, and lower. The upper part is the area above the tracheal carina, the middle part is the area between the tracheal carina and the lower pulmonary vein, and the lower part is the area below the lower pulmonary vein. The range of different CT signs in each area (the above 4 signs are 4 variables) is scored on a 5-level basis: Grade 0, normal lung tissue, scored as 0 points; Grade 1: lesion area < 25% of the layer, scored as 1 point; Grade 2: the lesion area occupies 25%-50% of the layer, which is scored as 2 points; Grade 3: the lesion area occupies 50%-75% of the layer, which is scored as 3 points; Grade 4: lesion area > 75% of the level, scored as 4 points; The HRCT score is scored by visually evaluating the area involved in each region of each variable. If the lesion involves multiple levels, the scores of each level are added up and averaged to obtain the score of the region (0-24 points). For example, if ground-glass density shadows are diffusely distributed on each level in each area of ​​both lungs, it is scored as 24 points.

[0064] 1.7.2.5 Number of acute respiratory infections Observe the number of acute respiratory tract infections that occur during treatment.

[0065] 1.7.2.6 Safety Observation The liver and kidney functions were observed before treatment and at 2 weeks and 28 days after treatment, and the occurrence of adverse events was recorded truthfully.

[0066] 1.7.3 Evaluation time point Table 2 Trial follow-up table 2. Statistical analysis SPSS 27 statistical software was used for statistical analysis of the data in this study, and all statistical tests were two-sided. p <0.05 was considered statistically significant. Mean ± SD was used for statistical description of measurement data. The measurement data that met the normal distribution were analyzed by t test, the inter-group comparison was analyzed by independent sample t test, the intra-group comparison was analyzed by paired t test, and the data that did not meet the normal distribution were analyzed by non-parametric test (rank sum test); the enumeration data were analyzed by chi-square test; and the rank sum test was analyzed by rank sum test.

[0067] 3. Results 3.1 TCM symptom score A total of 63 patients were included in this study, and the TCM symptom score data conformed to the normal distribution. The results showed that the TCM symptom scores of patients in the blank group and the TCM group showed a downward trend. After 28 days of treatment, the symptom score of the TCM group was significantly lower than that of the blank group ( P <0.05), while no significant difference was found in the scores between the two groups before treatment and after 14 days of treatment. The results showed that the Chinese medicine group had a significant advantage in improving the clinical symptoms of patients. The specific results are shown in Table 3.

[0068] Table 3 Comparison of TCM symptom scores between the two groups 3.2 Cough life quality score (LCQ) A total of 63 patients were included in this study, and the TCM symptom score data were in accordance with normal distribution. The results showed that the LCQ scores of patients in the blank group and the TCM group showed a downward trend. After 28 days of treatment, the LCQ score of the TCM group was significantly lower than that of the blank group ( P <0.05), while there was no significant difference in the scores between the two groups before treatment and after 14 days of treatment. The results showed that the quality of life of patients in the Chinese medicine group was significantly improved. The specific results are shown in Table 4.

[0069] Table 4 Comparison of cough life quality scores (LCQ) between the two groups 3.3 Blood routine white blood cell count and C-reactive protein (CRP) A total of 63 patients were included in this study. The white blood cell count and C-reactive protein in routine blood tests before treatment and 14 and 28 days after treatment were in accordance with normal distribution. The results showed that there was no significant statistical difference in white blood cell count and CRP between the two groups before treatment and 14 and 28 days after treatment. The specific results are shown in Table 5.

[0070] Table 5 Comparison of white blood cells and C-reactive protein between the two groups 3.4 Pneumonia chest CT score A total of 63 patients were included in this study. The chest CT score data of pneumonia conformed to the normal distribution. The results showed that there was no significant difference in the chest CT score of pneumonia between the two groups of patients before treatment. After 28 days of treatment, the chest CT score of pneumonia in the Chinese medicine group was significantly lower than that in the blank group ( P <0.05), showing that the absorption degree of pneumonia in the Chinese medicine group was significantly better than that in the blank group. The specific results are shown in Table 6.

[0071] Table 6 Comparison of chest CT scores of pneumonia between the two groups 3.5 Number of acute respiratory infections During the 28-day treatment period, no patient developed acute respiratory tract infection.

[0072] 3.6 Adverse reaction observation During the follow-up period of this study, no patient developed liver and kidney damage or palpitations. Adverse events included: 1 patient in the blank group had mild diarrhea, 1 patient in the Chinese medicine group had nausea and vomiting, and 2 patients had diarrhea, and the symptoms were relieved after symptomatic treatment such as antiemetic or antidiarrheal treatment.

Claims

1. A Chinese medicine composition for treating Qi and Yin deficiency and delayed absorption of lung collateral obstruction type pneumonia, characterized in that: The Chinese medicine composition consists of 10-15g of Pseudostellariae Radix, 10-15g of Asparagus cochinchinensis, 6-10g of Morus alba bark, 6-10g of Scutellaria baicalensis, 6-10g of Platycodon grandiflorum, 6-10g of Citrus aurantium, 6-10g of Fritillaria thunbergii, 10-15g of Trichosanthes root bark, 10-15g of Prunella vulgaris, 15-30g of raw oyster, 6-10g of Pheretima lumbarum, 10-15g of Salvia miltiorrhiza, 6-10g of Curcuma zedoariae and 6-10g of raw liquorice.

2. The Chinese medicine composition for treating Qi and Yin deficiency and delayed absorption of lung collateral obstruction type pneumonia according to claim 1, characterized in that: The Chinese medicine composition is added with 6-10g of Radix Rehmanniae, 5-10g of Rhizoma Anemarrhenae, 6-10g of Phellodendron chinense and 6-10g of Radix Rehmanniae, which is suitable for both qi and yin deficiency and deficiency-heat syndrome to achieve the effects of nourishing yin and clearing heat. The combination of the two can enhance the effects of invigorating qi and nourishing yin, nourishing yin and clearing heat, moistening the lungs and relieving cough.

3. The Chinese medicine composition for treating Qi and Yin deficiency and delayed absorption of lung collateral obstruction type pneumonia according to claim 1, characterized in that: The Chinese medicine composition is added with 6-10g of Psoralea corylifolia, 6-9g of dried ginger, 3-6g of cinnamon bark, and 5-10g of gecko powder, which is suitable for deficiency of both qi and yin, and deficiency-cold syndrome, so as to achieve the effect of warming and tonifying the lungs and kidneys. The two are used together to strengthen the power of invigorating qi and nourishing yin, warming and transforming phlegm and fluid, and tonifying the kidney and absorbing qi.

4. A pharmaceutical preparation based on the Chinese medicine composition for treating delayed absorption of qi and yin deficiency and lung collateral obstruction type pneumonia according to any one of claims 1 to 3, characterized in that: Medically acceptable auxiliary materials are added to the formula of the traditional Chinese medicine composition to prepare any one of decoctions, granules, pills, tablets, capsules, ointments, syrups, powders and granules.

5. The pharmaceutical preparation of the Chinese medicine composition for treating delayed absorption of qi and yin deficiency and lung collateral obstruction type pneumonia according to claim 4, characterized in that: The granules are prepared by the following steps: (1) Decoction: Add water to each ingredient of the formula at a weight ratio of 1:6-10 and decoct for 1-3 times, each time for 30-60 minutes, and combine the decoctions; (2) Concentration: The decoction is concentrated into a thick paste at 50-75°C and a vacuum degree of -0.02-0.06 MPa. The density of the thick paste at 50°C is 1.20 g / ml. (3) Drying: Dry the thick paste at 60~70℃ and -0.02~-0.06MPa vacuum to form a dry paste for later use; (4) The dry paste is crushed and passed through a 100-mesh sieve to obtain a mixed dry paste powder. 10 to 30 g of granulation excipients are added and mixed evenly. An appropriate amount of 70% to 90% ethanol is added and wet granulated. After drying, granules are obtained.

6. The pharmaceutical preparation of the Chinese medicine composition for treating delayed absorption of Qi and Yin deficiency and lung collateral obstruction type pneumonia according to claim 5, characterized in that The granulation auxiliary material is one or a combination of dextrin, maltodextrin or sucrose.

7. The pharmaceutical preparation of the Chinese medicine composition for treating delayed absorption of Qi and Yin deficiency and lung collateral obstruction type pneumonia according to claim 4, characterized in that: The pills are prepared by the following steps: (1) Decoction: weigh each medicinal ingredient according to the formula, add water at a weight ratio of 1:6-10, and decoct for 1-3 times, each time for 35-45 minutes, and combine the decoctions; (2) Concentration: The decoction is concentrated into a thick paste at 50-75°C and a vacuum degree of -0.02-0.06 MPa. The density of the thick paste is 1.20-1.35 g / ml at 50-60°C. (3) Drying: Dry the thick paste at 50~75℃ and -0.02~0.06MPa vacuum to form a dry paste for later use; (4) Crush the dry paste and pass it through a 100-mesh sieve to obtain a mixed dry paste powder. Then, mix it with water or an ethanol aqueous solution with a concentration of 30% or less to make pills.

8. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of drugs for the treatment of delayed absorption of qi and yin deficiency and lung meridian obstruction type pneumonia.

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