Electric field treatment device for relieving inflammation

Abstract

The invention provides an electric field treatment device for relieving inflammation, and relates to the technical field of medical treatment equipment. The device comprises a Bluetooth programmable power supply and a patch electrode, the patch electrode comprises a flexible circuit board, one surface of the flexible circuit board is provided with a plurality of concentric conductive rings at equal intervals, and the other surface of the flexible circuit board is provided with conductive circuits connected with the conductive rings; and the Bluetooth programmable power supply is used for receiving output voltage information sent by a user side, supplying power to the conductive ring according to the received output voltage information, and feeding back current and voltage during power supply to the user side. The device has a good anti-inflammatory effect on skin inflammation through electrical stimulation.

Description

Technical Field

[0001] The present invention relates to the technical field of medical treatment equipment, and in particular to an electric field treatment device for alleviating inflammation. Background Art

[0002] The skin is the largest organ in the human body, which protects the internal tissues and organs of the human body from invasion by harmful external factors. The skin will undergo pathological changes under the influence of multiple factors such as genetic susceptibility, immune disorders, environmental changes, and invasion of pathogenic microorganisms, thus developing into different inflammatory skin diseases such as urticaria, atopic dermatitis, and psoriasis. At present, the drugs for the treatment of inflammatory skin diseases include: topical drugs, ultraviolet therapy, conventional drugs, biological agents, and small molecule drugs. However, in clinical practice, the response durability of many biological agents is limited, and it takes 1 to 2 years to achieve a therapeutic effect. Therefore, it is of great significance to further explore the pathogenesis of inflammatory skin diseases and efficient treatment methods.

[0003] The application of electrical stimulation in physiology and medicine can be traced back to 4000 BC. However, it was not until the end of the 18th century that the Italian scientist Galvani proposed the "bioelectricity" in frog muscles, which aroused great interest in this field. Since then, electrotherapy has been successfully applied to a variety of diseases such as clinical fracture treatment, nerve fiber repair, soft tissue regeneration and cancer treatment. Although electrical stimulation is widely used in physiology and medical science, its application in the treatment of inflammatory skin diseases remains a challenge because they have a natural pathological stratum corneum barrier and lack an effective combination with chemotherapy to achieve specific immunomodulation. At present, it is of great significance to study the role of electrical stimulation in alleviating skin inflammation. Summary of the invention

[0004] In order to solve the deficiencies in the background technology, the present invention provides an electric field treatment device for relieving inflammation, which has a good anti-inflammatory effect on skin inflammation through electrical stimulation.

[0005] The object of the present invention is to provide an electric field therapy device for relieving inflammation, comprising a Bluetooth programmable power supply and a patch electrode; The patch electrode comprises a flexible circuit board, one side of the flexible circuit board is provided with a plurality of equally spaced concentric conductive rings, and the other side of the flexible circuit board is provided with a conductive line connected to each conductive ring; Wherein, adjacent conductive rings are connected to different conductive lines, and a directional electric field is formed between adjacent conductive rings; The Bluetooth programmable power supply is used to receive the output voltage information sent by the user end, supply power to the patch electrode according to the received output voltage information, and feed back the real-time current and voltage of the output end to the user end.

[0006] Preferably, the Bluetooth programmable power supply comprises a Bluetooth module and a programmable power supply module; The Bluetooth module is used to receive the output voltage information sent by the user end, and control the programmable power supply module to adjust the output voltage according to the output voltage information to supply power to the conductive ring; The Bluetooth module collects the current and voltage at the output end of the programmable power supply module in real time and feeds them back to the user end.

[0007] Preferably, the Bluetooth programmable power supply further includes a data storage module for storing current and voltage information during power supply.

[0008] Preferably, the Bluetooth programmable power supply is powered by a lithium battery.

[0009] Preferably, among the multiple equally spaced concentric conductive rings, each of the conductive rings is arranged on the same side of the flexible circuit board and is arranged in concentric rings at equidistant positions.

[0010] Preferably, each of the conductive rings has a solder resist layer removed and is gold plated.

[0011] Preferably, the flexible circuit board uses polyimide or polyester film as a substrate.

[0012] Preferably, the patch electrode has a side with a conductive ring that fits the skin.

[0013] Compared with the prior art, the present invention has the following beneficial effects: The present invention provides an electric field treatment device for relieving inflammation. The present invention designs an electric field chamber to detect the anti-inflammatory activity of electric stimulation on a mouse skin inflammation model. Experiments have shown that electric stimulation has a good anti-inflammatory effect on mouse skin inflammation. In a mouse skin inflammation model, electric stimulation inhibits inflammation by 42.7% (5s) at 5V. The present invention provides useful assistance for treating related diseases and is of great significance in the field of medicine. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 A schematic diagram of an electric field treatment device for relieving inflammation provided by the present invention.

[0015] Figure 2 The anti-inflammatory effect of electrical stimulation was evaluated in the mouse skin inflammation model. *, P<0.05, ****, P<0.0001, compared with the model, t-test between the two groups. Electrical stimulation has significant anti-inflammatory activity. DETAILED DESCRIPTION

[0016] Several specific embodiments of the present invention are described in detail below, but it should be understood that the protection scope of the present invention is not limited by the specific embodiments.

[0017] The purpose of the present invention is to solve the shortcomings of the prior art that the switch durability test device is generally only suitable for tests without counting monitoring function, the test cycle cannot be adjusted, and the test variety is single, and an electric field therapy device for relieving inflammation is proposed, which has a counting function, adjustable test speed and can be used for various gear switches.

[0018] To achieve the above purpose, see Figure 1 As shown, the present invention provides an electric field treatment device for relieving inflammation, comprising a Bluetooth programmable power supply 1 and a patch electrode; The patch electrode comprises a flexible circuit board 2, one side of the flexible circuit board 2 is provided with a plurality of equally spaced concentric conductive rings 2-1, and the other side of the flexible circuit board 2 is provided with a conductive line 2-2 connected to each conductive ring; Wherein, adjacent conductive rings are connected to different conductive lines, and a directional electric field is formed between adjacent conductive rings; The Bluetooth programmable power supply is used to receive the output voltage information sent by the user end, supply power to the patch electrode according to the received output voltage information, and feed back the real-time current and voltage of the output end to the user end.

[0019] Wherein, the Bluetooth programmable power supply includes a Bluetooth module and a programmable power supply module; The Bluetooth module is used to receive the output voltage information sent by the user end, and control the programmable power supply module to adjust the output voltage according to the output voltage information to supply power to the conductive ring; The Bluetooth module collects the current and voltage at the output end of the programmable power supply module in real time and feeds them back to the user end.

[0020] The Bluetooth programmable power supply also includes a data storage module for storing information such as current and voltage during power supply. The Bluetooth programmable power supply is powered by a lithium battery.

[0021] Each of the conductive rings is arranged on the same side of the flexible circuit board, arranged at equidistant positions in the form of concentric rings and plated with gold.

[0022] The flexible circuit board uses polyimide or polyester film as a base material.

[0023] The surface of the circular film of the patch electrode with the gold-plated conductive ring is in contact with the skin.

[0024] In one embodiment, an electric field therapy device for relieving skin inflammation includes a Bluetooth programmable power supply and a patch electrode. The Bluetooth programmable power supply sets the output voltage of the programmable power supply through a mobile phone APP, and uses the ADC module inside the Bluetooth chip to collect the current and voltage at the output end in real time and feedback the display to the mobile phone APP end; the patch electrode is designed based on a double-layer flexible circuit board, and equidistant concentric conductive rings are designed on one side of the flexible circuit board. A directional electric field is formed between adjacent conductive rings, and power is taken by inserting the FFC connection socket at the output end of the Bluetooth programmable power supply. The Bluetooth programmable power supply is powered by a lithium battery and has a data storage function; the concentric conductive rings are powered by two conductive lines on the other side of the flexible circuit board; the adjacent concentric conductive rings are connected to different conductive lines; the solder mask is removed from the position of the concentric conductive rings and gold-plated; the flexible circuit board facilitates the deformation of the patch electrode to fit closely with the skin.

[0025] In order to illustrate the electric field treatment device for relieving skin inflammation provided by the present invention, a mouse skin inflammation model was used to evaluate the animal anti-inflammatory activity.

[0026] The technical solution adopted by the present invention is: for the treatment device designed by the present invention, electrical stimulation has a significant anti-inflammatory effect on a mouse skin inflammation model.

[0027] The mouse skin inflammation model was used to evaluate the anti-inflammatory activity of animals. The principle is: 2,4-dinitrochlorobenzene (DNCB) was used as a hapten to sensitize and stimulate mice to successfully establish a mouse skin inflammation model. Using DNCB-induced mouse dermatitis as an experimental model, the scratching behavior and skin lesions of mice were measured to detect the degree of inflammation.

[0028] Scratching behavior: After the mouse modeling was completed, the mouse was placed alone and the number of times the mouse scratched its back was observed within 60 min. Continuous scratching was counted as one time.

[0029] Skin lesion manifestations: The severity of inflammation in the skin lesions of mice was scored. It was judged based on four symptoms: dryness / scaling, bleeding / rash, ulceration / exfoliation, and edema. Each symptom was scored as 0 (none), 1 (mild), 2 (moderate), and 3 (severe). The final score was the sum of the four symptoms. The skin tissue inflammation score ranged from 0 to 12 points.

[0030] Clinical trials Mouse skin inflammation model was used to evaluate the anti-inflammatory effect of electrical stimulation.

[0031] 1) Experimental animals: The experimental mice were kept in an SPF environment with an ambient temperature of 20-26°C, a humidity of 40% - 60%, and a 12-hour alternating cycle of day and night. Mice were kept in 5-6 cages and were free to eat and drink.

[0032] 2) Experimental grouping: The experiment was divided into 4 groups: Ctrl group (control group), Model group (inflammation model group), DC group (electrical stimulation only group), and Model+DC group (inflammation model group and electrical stimulation group). The number of mice in each group was the same (10 mice / group).

[0033] 3) Mouse skin inflammation model: ① Healthy C57BL / 6 mice aged 6-8 weeks were randomly divided into 4 groups.

[0034] ② After one week of routine laboratory feeding, the back skin tissues of all mice were depilated. On the 1st, 4th and 7th days of the experiment, 1.0% DNCB (200 μL) solution was applied to the back skin tissues of mice in the dermatitis model group for sensitization, and applied 3 times in total. On the 14th, 17th, 19th, 22nd, 24th, 27th and 29th days of the experiment, 0.5% DNCB (20 μL) solution was repeatedly applied to the back skin tissues of mice for inflammation, and applied 7 times in total. The mice in the control group were smeared with an equal volume of PBS solution at the same time point. Every day, the back skin of the mice in the electrical stimulation group was given 5V electrical stimulation for 5s by the treatment device provided by the present invention. On the last day, the mice were counted for scratching and scored for inflammation.

[0035] Inhibition rate = (inflammation score of the Model group - inflammation score of the Model + DC group) / (inflammation score of the Model group) × 100% Reference Figure 2 In the mouse skin inflammation model, the Model+DC group reduced the number of scratching by 22.9% at 5V, 5s (a), and inhibited skin inflammation by 42.7% (b).

[0036] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An electric field treatment device for relieving inflammation, characterized in that: Includes Bluetooth programmable power supply and patch electrodes; The patch electrode comprises a flexible circuit board, one side of the flexible circuit board is provided with a plurality of equally spaced concentric conductive rings, and the other side of the flexible circuit board is provided with a conductive line connected to each conductive ring; Wherein, adjacent conductive rings are connected to different conductive lines, and a directional electric field is formed between adjacent conductive rings; The Bluetooth programmable power supply is used to receive the output voltage information sent by the user end, supply power to the patch electrode according to the received output voltage information, and feed back the real-time current and voltage of the output end to the user end.

2. The electric field treatment device for relieving inflammation according to claim 1, characterized in that: The Bluetooth programmable power supply includes a Bluetooth module and a programmable power supply module; The Bluetooth module is used to receive the output voltage information sent by the user end, and control the programmable power supply module to adjust the output voltage according to the output voltage information to supply power to the conductive ring; The Bluetooth module collects the current and voltage at the output end of the programmable power supply module in real time and feeds them back to the user end.

3. The electric field treatment device for relieving inflammation according to claim 2, characterized in that: The Bluetooth programmable power supply also includes a data storage module for storing current and voltage information during power supply.

4. The electric field treatment device for relieving inflammation according to claim 1, characterized in that: The Bluetooth programmable power supply is powered by a lithium battery.

5. The electric field treatment device for relieving inflammation according to claim 1, characterized in that: Among the multiple equally spaced concentric conductive rings, each of the conductive rings is arranged on the same side of the flexible circuit board and is arranged in concentric rings at equidistant positions.

6. The electric field treatment device for relieving inflammation according to claim 1, characterized in that: The solder resist layer of each conductive ring is removed and gold-plated.

7. The electric field treatment device for relieving inflammation according to claim 1, characterized in that: The flexible circuit board uses polyimide or polyester film as a base material.

8. The electric field treatment device for relieving inflammation according to claim 1, characterized in that: The patch electrode has a side with a conductive ring that fits the skin.

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