Method for improving yield of red ginseng, extract and application of extract

Abstract

The invention provides a method for improving the yield of red ginseng, an extract and application of the extract, and belongs to the technical field of traditional Chinese medicine, the method for improving the yield of red ginseng, the extract and the application of the extract comprise the steps of raw material preparation, smashing treatment, extraction solvent selection, extraction, filtration and separation, concentration and drying, and the powdery red ginseng extract can be obtained. The extract has the effects of resisting aging, balancing water and oil, relieving, repairing and supplementing nutrients, can be applied to the fields of medicines, health care products, cosmetics and the like, improves the quality and the medicine effect of red ginseng, remarkably improves the yield and the purity of the extract, and expands the application range of the extract.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a method for improving the yield of red ginseng, an extract and application of the extract. Background Art

[0002] As an important Chinese medicinal material, red ginseng has rich medicinal value. However, there are some problems in the traditional processing and extraction of red ginseng. The traditional processing method is difficult to ensure the full conversion and retention of the effective ingredients in red ginseng, resulting in uneven quality and efficacy of red ginseng. In the steaming and drying process, the control of parameters such as temperature and time is not precise enough, which easily causes the loss and destruction of effective ingredients. On the other hand, the conventional extraction method is inefficient, the yield of the extract is not high, the selection and use of the solvent is not reasonable, and the effective ingredients in red ginseng cannot be fully dissolved and extracted. At the same time, the process conditions in the extraction process are not optimized, which also affects the purity and quality of the extract.

[0003] This solution aims to solve the problems existing in the prior art. By accurately controlling various parameters in the processing of red ginseng, such as optimizing the temperature, time and humidity of steaming and drying, the effective ingredients can be retained and converted to the greatest extent, thereby improving the quality and efficacy of red ginseng. In terms of extraction, a more scientific and reasonable solvent system and advanced extraction technology are adopted, and the types, concentrations and ratios of solvents are deeply studied and screened to improve the solubility of effective ingredients. At the same time, new extraction equipment and processes are introduced, such as supercritical fluid extraction and microwave-assisted extraction, which significantly improve the yield and purity of the extract. In addition, the present invention also expands the application of red ginseng extract, giving full play to its anti-aging, water-oil balance, soothing and repairing, and nutrient supplementation effects, so that it can be used in the fields of medicine, health products, cosmetics, etc. Summary of the invention

[0004] The purpose of the present invention is to provide a method for improving the yield of red ginseng, an extract and an application of the extract, aiming to solve the problem that the traditional processing method in the prior art is difficult to ensure the full conversion and retention of the active ingredients in the red ginseng, resulting in uneven quality and efficacy of the red ginseng. In the steaming and drying links, the control of parameters such as temperature and time is not precise enough, which easily causes the loss and destruction of the active ingredients. On the other hand, the conventional extraction method is inefficient, the yield of the extract is not high, the selection and use of the solvent is not reasonable, and the active ingredients in the red ginseng cannot be fully dissolved and extracted. At the same time, the process conditions in the extraction process are not optimized enough, which also affects the purity and quality of the extract.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] The method for improving the yield of red ginseng, the extract and the application of the extract are characterized by comprising the following steps:

[0007] S1. Raw material preparation: Carefully select high-quality, pest-free and intact red ginseng as raw materials, and clean the red ginseng carefully to completely remove impurities and dust on its surface;

[0008] S2. Crushing: After cutting the red ginseng into small pieces, use professional crushing equipment to crush it into uniform and fine particles. Pay attention to controlling the degree of crushing. Generally, it is best to be able to pass through a 60-mesh screen, which is conducive to the full dissolution of the active ingredients in the subsequent extraction process;

[0009] S3. Selection of extraction solvent: A mixed solution of ethanol and water is preferably used as the extraction solvent. Usually, the concentration of ethanol can be set at about 60%. The ratio of water to ethanol can be optimized according to specific experimental conditions and target components, such as using a 1:1 ratio;

[0010] S4, extraction process: according to the ratio of red ginseng to extraction solvent of 1:8, the crushed red ginseng is placed in an extraction container, the temperature is controlled at 70°C in a constant temperature heating device, and the extraction is carried out while stirring at a constant speed. The extraction time is about 3 hours. In order to fully extract the effective ingredients, the extraction can be repeated 2-3 times;

[0011] S5, filtration and separation: After the extraction is completed, the extract is first filtered using multiple layers of gauze to remove larger solid residues, and then centrifuged at 3000 rpm for 15 minutes to further separate the pure extract;

[0012] S6. Concentration and drying: The extract is concentrated to about 1 / 5 of its original volume by a reduced pressure concentration device at a temperature of 60°C and a vacuum degree of -0.08MPa. Finally, the concentrate is freeze-dried at -40°C for 24 hours using a vacuum freeze-drying method to obtain a powdered red ginseng extract.

[0013] As a preferred solution of the present invention, the red ginseng extract has the effects of anti-aging, water-oil balance, soothing and repairing, and supplementing nutrients.

[0014] Compared with the prior art, the present invention has the following beneficial effects:

[0015] 1. In this scheme, by precisely controlling various parameters in the processing of red ginseng, such as optimizing the temperature, time and humidity of steaming and drying, the effective ingredients are retained and converted to the greatest extent, thereby improving the quality and efficacy of red ginseng. In terms of extraction, a more scientific and reasonable solvent system and advanced extraction technology are adopted, and the types, concentrations and ratios of solvents are deeply studied and screened to improve the solubility of effective ingredients. At the same time, new extraction equipment and processes are introduced, such as supercritical fluid extraction and microwave-assisted extraction, which significantly improve the yield and purity of the extract. This scheme gives full play to the anti-aging, water-oil balance, soothing and repairing, and nutrient supplement effects of red ginseng extract, so that it can be used in the fields of medicine, health products, cosmetics, etc., expanding its application range. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. They are used to explain the present invention together with the embodiments of the present invention and do not constitute a limitation of the present invention.

[0017] In the attached picture:

[0018] Figure 1 The figure is a flow chart of the preparation method of the red ginseng extract of the present invention. DETAILED DESCRIPTION

[0019] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0020] Example 1

[0021] See also Figure 1 , the present invention provides the following technical solutions:

[0022] The method for improving the yield of red ginseng, the extract and the application of the extract are characterized by comprising the following steps:

[0023] S1. Raw material preparation: Carefully select high-quality, pest-free and intact red ginseng as raw materials, and clean the red ginseng carefully to completely remove impurities and dust on its surface;

[0024] S2. Crushing: After cutting the red ginseng into small pieces, use professional crushing equipment to crush it into uniform and fine particles. Pay attention to controlling the degree of crushing. Generally, it is best to be able to pass through a 60-mesh screen, which is conducive to the full dissolution of the active ingredients in the subsequent extraction process;

[0025] S3. Selection of extraction solvent: A mixed solution of ethanol and water is preferably used as the extraction solvent. Usually, the concentration of ethanol can be set at about 60%. The ratio of water to ethanol can be optimized according to specific experimental conditions and target components, such as using a 1:1 ratio;

[0026] S3, extraction process: according to the ratio of red ginseng to extraction solvent of 1:8, the crushed red ginseng is placed in an extraction container, the temperature is controlled at 70°C in a constant temperature heating device, and the extraction is carried out while stirring at a constant speed. The extraction time is about 3 hours. In order to fully extract the effective ingredients, the extraction can be repeated 2-3 times;

[0027] S4, filtration and separation: After the extraction is completed, the extract is first filtered using multiple layers of gauze to remove larger solid residues, and then centrifuged at 3000 rpm for 15 minutes to further separate the pure extract;

[0028] S5. Concentration and drying: The extract is concentrated to about 1 / 5 of its original volume by a reduced pressure concentration device at a temperature of 60°C and a vacuum degree of -0.08MPa. Finally, the concentrate is freeze-dried at -40°C for 24 hours using a vacuum freeze-drying method to obtain a powdered red ginseng extract.

[0029] In a specific embodiment of the present invention,

[0030] S1. Raw material preparation: When selecting red ginseng as raw material, strict control is required from multiple aspects. First, observe the appearance of red ginseng, and choose red ginseng with dark red color, solid texture, clear texture and natural fragrance, which indicates that its growth environment is good and the nutrition accumulation is sufficient. For the morphological integrity of red ginseng, it is necessary to ensure that there are no obvious fractures, damages or insect bites. Red ginseng without pests and diseases is the key. Carefully check whether there are worm holes, spots or abnormal discoloration on the surface to exclude the possibility of being attacked by pests and diseases. When cleaning red ginseng, use a gentle method to avoid damaging it. You can first use a soft brush to gently brush off the dust on the surface, and then wipe it gently with a clean damp cloth to remove the remaining impurities. During the cleaning process, pay attention to maintaining the integrity and original characteristics of the red ginseng;

[0031] S2. Crushing: When cutting red ginseng into small pieces, use sharp and clean knives to ensure that the cutting surface is neat and reduce excessive damage to the red ginseng tissue. The size of the small pieces after cutting should be as uniform as possible to facilitate the consistency of subsequent crushing. When using professional crushing equipment, adjust the parameters of the equipment according to the characteristics of red ginseng and the required degree of crushing, such as rotation speed, crushing time, etc. The particle size that can pass through the 60-mesh screen is moderate, which can not only increase the contact area with the extraction solvent, but also help to improve the extraction efficiency. During the crushing process, pay close attention to the operation of the equipment to avoid excessive crushing that leads to the loss of active ingredients or the introduction of too many impurities. At the same time, in order to ensure the stability of the extraction effect, the amount of red ginseng crushed each time should be kept relatively consistent;

[0032] S3. Selection of extraction solvent: The mixed solution of ethanol and water has many advantages as an extraction solvent. Ethanol has good solubility and can effectively extract a variety of active ingredients in red ginseng. The addition of water can adjust the polarity of the solvent, making it more suitable for the extraction of different types of active ingredients. When determining the ethanol concentration to be about 60%, the solubility and extraction effect of various components in red ginseng at this concentration are comprehensively considered. In addition to the common choice of 1:1, the ratio of water to ethanol can also be adjusted according to the specific experimental purpose and the properties of the components to be extracted. For example, if the focus is on extracting hydrophilic components, the proportion of water can be appropriately increased; if the focus is on extracting lipophilic components, the proportion of water can be reduced. In addition, experimental conditions such as temperature, pressure and other factors will also affect the choice of solvent ratio, and the optimal ratio needs to be determined through preliminary experiments and analysis;

[0033] S4. Extraction process: During the extraction operation, it is very important to mix the red ginseng and the extraction solvent in a ratio of 1:8. This ratio has been tested and optimized many times, and can save the solvent usage to the greatest extent while ensuring the extraction efficiency. When the crushed red ginseng is placed in the extraction container, it is necessary to ensure uniform distribution so that it can fully contact the solvent. The constant temperature heating device is precisely controlled to 70°C. This temperature can promote the rapid and stable dissolution of the effective ingredients, while avoiding the destruction or deterioration of the ingredients caused by excessive temperature. Uniform stirring plays a key role in the extraction process. It can break the concentration gradient, fully mix the red ginseng particles with the solvent, and speed up the extraction speed. The extraction time of about 3 hours is determined based on comprehensive consideration of the extraction efficiency and cost. By repeating the extraction 2-3 times, the effective ingredients in the red ginseng can be fully extracted, and the yield and quality of the extract can be improved. Each time the extraction is repeated, the extraction time and conditions can be appropriately adjusted to achieve the best effect. In addition, during the extraction process, parameters such as temperature and stirring speed should be closely monitored to ensure the stability and consistency of the extraction.

[0034] S5, filtration and separation: The filtration and separation steps after the extraction are completed are to obtain a pure extract. First, use multiple layers of gauze for preliminary filtration. This traditional method is simple and effective, and can quickly remove larger solid residues. The number of layers and material selection of gauze will affect the filtration effect. Generally, fine and corrosion-resistant gauze is selected. After preliminary filtration, centrifugal separation is used for further purification. Centrifugation at a speed of 3000rpm for 15 minutes can use centrifugal force to precipitate tiny solid particles and impurities, thereby obtaining a purer supernatant, i.e., the extract. During the centrifugation process, the balance of the centrifuge must be ensured to avoid machine failure and experimental errors caused by imbalance. At the same time, according to the properties of the extract and the impurity content, the speed and time of centrifugation can also be appropriately adjusted to achieve the ideal separation effect;

[0035] S6. Concentration and drying: When concentrating the extract, the vacuum concentration device can quickly evaporate the solvent at a lower temperature by controlling the temperature at 60°C and the vacuum degree at -0.08MPa, thereby reducing the loss and thermal denaturation of the active ingredients and concentrating the extract to about 1 / 5 of the original volume, which is convenient for subsequent drying treatment and can ensure the concentration of the active ingredients. Vacuum freeze drying is an advanced drying method. At a low temperature of -40°C, the water in the extract is directly sublimated from the solid state to the gas state, avoiding the destruction of the active ingredients by high temperature and retaining the activity and quality of the extract to the greatest extent. Freeze drying for 24 hours can ensure that the water is fully removed to obtain a dry, uniform, loose and porous powdered red ginseng extract. This form of extract is easy to store, transport and process in the future. During the entire concentration and drying process, the environmental conditions and operating parameters must be strictly controlled to ensure the quality and stability of the product. At the same time, the equipment must be regularly maintained and calibrated to ensure its normal operation and accuracy.

[0036] The preliminary preparation is the same as the traditional solvent extraction method, which involves the selection, cleaning and crushing of raw materials. The ultrasonic equipment is set up with an ultrasonic generator with a power of 600W and a frequency of 40kHz. During the extraction process, the crushed red ginseng and the extraction solvent (the ratio of red ginseng to the extraction solvent is 1:10, and the solvent is 70% ethanol aqueous solution) are placed in a special ultrasonic extraction container, and the ultrasonic equipment is started. Under the action of ultrasound, the temperature is controlled at 60°C and the extraction is performed for 1.5 hours.

[0037] Subsequent processing: The subsequent filtration, separation, concentration and drying steps are the same as those of the traditional solvent extraction method. The above two extraction processes can be selected and optimized according to actual needs and experimental conditions to obtain red ginseng extract with higher yield and quality.

[0038] For details, please refer to Figure 1 Red ginseng extract has the effects of anti-aging, water-oil balance, soothing and repairing, and replenishing nutrients.

[0039] In this embodiment: red ginseng extract has a significant effect on regulating the water-oil balance of the skin. It can enhance the skin's moisturizing ability and promote the production of natural moisturizing factors in the skin, such as hyaluronic acid and ceramide. These moisturizing factors can help the skin lock in moisture, prevent moisture loss, and keep the skin hydrated. At the same time, red ginseng extract can also regulate sebum secretion. Excessive sebum secretion can cause oily skin and prone to acne and pimples; insufficient sebum secretion can make the skin dry and rough. Red ginseng extract can balance the secretion of sebum, so that the skin reaches an ideal water-oil balance state, presenting a healthy and smooth appearance.

[0040] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A method for improving the yield of red ginseng, an extract and an application of the extract, characterized in that: Including the following steps: S1. Raw material preparation: Carefully select high-quality, pest-free and intact red ginseng as raw materials, and clean the red ginseng carefully to completely remove impurities and dust on its surface; S2. Crushing: After cutting the red ginseng into small pieces, use professional crushing equipment to crush it into uniform and fine particles. Pay attention to controlling the degree of crushing. Generally, it is best to be able to pass through a 60-mesh screen, which is conducive to the full dissolution of the active ingredients in the subsequent extraction process; S3. Selection of extraction solvent: A mixed solution of ethanol and water is preferably used as the extraction solvent. Usually, the concentration of ethanol can be set at about 60%. The ratio of water to ethanol can be optimized according to specific experimental conditions and target components, such as using a 1:1 ratio; S4, extraction process: according to the ratio of red ginseng to extraction solvent of 1:8, the crushed red ginseng is placed in an extraction container, the temperature is controlled at 70°C in a constant temperature heating device, and the extraction is carried out while stirring at a constant speed. The extraction time is about 3 hours. In order to fully extract the effective ingredients, the extraction can be repeated 2-3 times; S5, filtration and separation: After the extraction is completed, the extract is first filtered using multiple layers of gauze to remove larger solid residues, and then centrifuged at 3000 rpm for 15 minutes to further separate the pure extract; S6. Concentration and drying: The extract is concentrated to about 1 / 5 of its original volume by a reduced pressure concentration device at a temperature of 60°C and a vacuum degree of -0.08MPa. Finally, the concentrate is freeze-dried at -40°C for 24 hours using a vacuum freeze-drying method to obtain a powdered red ginseng extract.

2. The use of the red ginseng extract in the preparation of medicines according to claim 1, characterized in that: Red ginseng extract has the effects of anti-aging, water-oil balance, soothing and repairing, and replenishing nutrients.

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