Cognitive impairment auxiliary evaluation method, system, equipment and medium

Abstract

The invention relates to the technical field of medical data processing, and discloses a cognitive impairment auxiliary evaluation method, system, device and medium, evaluation is carried out on subjects in the aspects of instantaneous memory, dementia screening and delayed memory, the instantaneous memory comprises instant retelling and the like, the dementia screening comprises time calculation, reading, mathematical calculation, action simulation and the like, and the dementia screening and delayed memory evaluation can be carried out on the subjects. The delayed memory comprises delayed memory repeating of unprompted clues, delayed memory repeating of prompted clues and the like, the overall evaluation process covers memory, execution, visual space, language, calculation, concept reasoning cognitive domain and the like, Chinese language features are integrated, doctors are effectively assisted in comprehensive and accurate cognitive impairment evaluation on subjects, and the evaluation efficiency is improved. And the working efficiency of medical staff is greatly improved.

Description

Technical Field

[0001] The present invention relates to the field of medical data processing technology, and in particular to a method, system, device and medium for assisting in evaluating cognitive dysfunction. Background Art

[0002] In clinical work, doctors sometimes need to evaluate the cognitive function of some subjects. The most commonly used cognitive function evaluation methods are the Mini-mental state examination (MMSE) and the Montreal Cognitive Assessment (MoCA). However, MMSE has some shortcomings, such as more items involving language functions and fewer items involving executive functions. In addition, MMSE was developed by Folstein et al. in the United States in 1975 and cannot well reflect the characteristics of Chinese language and culture. In fact, in addition to memory loss, patients with cognitive dysfunction can also show executive function, visual space, language, calculation or conceptual reasoning disorders, etc., and MMSE does not cover these cognitive dysfunction evaluation methods. The content of MoCA is greatly affected by cultural and linguistic background. At the same time, MoCA is highly sensitive to the educational level of the subjects. People with low education or illiteracy often score lower. Although there are educational compensation points, it is still difficult to completely eliminate the bias. In addition, the test content of MoCA is relatively complex and takes a long time to complete. It is difficult to operate for the elderly or patients with severe cognitive impairment, which limits its scope of application in clinical work. Therefore, both MMSE and MoCA are difficult to assist doctors in evaluating the cognitive functions of subjects efficiently and accurately.

[0003] Therefore, there is an urgent need for a simple auxiliary evaluation method for cognitive dysfunction that is in line with the characteristics of the Chinese language and less affected by cultural education. Summary of the invention

[0004] The present invention provides a method, system, device and medium for assisting evaluation of cognitive dysfunction, so as to solve the defect that MMSE is difficult to assist doctors to accurately evaluate the cognitive function of subjects.

[0005] The present invention provides a method for assisting in evaluating cognitive dysfunction, comprising: Receive the subjects' immediate memory data, dementia screening data, and delayed memory data; According to the subjects' immediate memory data, dementia screening data, and delayed memory data, the preset evaluation rules are used to obtain the auxiliary evaluation results of the subjects' cognitive dysfunction.

[0006] According to a cognitive dysfunction auxiliary evaluation method provided by the present invention, the dementia screening data includes any one of the following or any combination thereof: time estimation data, reading data, mathematical calculation data, and action imitation data.

[0007] According to a cognitive dysfunction auxiliary evaluation method provided by the present invention, the time calculation data includes date calculation data and / or clock calculation data based on Chinese.

[0008] According to a cognitive dysfunction auxiliary evaluation method provided by the present invention, the mathematical calculation data includes any one of the following items or any combination thereof: digital comparison data and / or mathematical operation data.

[0009] According to a cognitive dysfunction auxiliary evaluation method provided by the present invention, the action imitation data includes single action imitation data and / or series action imitation data.

[0010] According to a cognitive dysfunction auxiliary evaluation method provided by the present invention, the delayed memory data includes delayed memory data without prompting cues and / or delayed memory data with prompting cues.

[0011] According to a method for assisting evaluation of cognitive dysfunction provided by the present invention, the method obtains the assisting evaluation result of cognitive dysfunction of the subject by using preset evaluation rules based on the subject's instantaneous memory data, dementia screening data, and delayed memory data, including: According to the subject's immediate memory data, dementia screening data, and delayed memory data, the subject's immediate memory score, dementia screening score, and delayed memory score are obtained; According to the subjects' immediate memory scores, dementia screening scores, and delayed memory scores, the preset evaluation rules are used to obtain the auxiliary evaluation results of the subjects' cognitive dysfunction.

[0012] A method for assisting evaluation of cognitive dysfunction provided by the present invention further comprises: Obtain the subjects' MMSE evaluation data and MoCA evaluation data; The auxiliary evaluation results of cognitive dysfunction of the subjects were correlated with their MMSE evaluation data and MoCA evaluation data to verify the validity of the auxiliary evaluation results of cognitive dysfunction of the subjects.

[0013] It should be noted that all steps in the cognitive dysfunction auxiliary evaluation method provided by the present invention can be implemented by computer.

[0014] The present invention also provides a cognitive dysfunction auxiliary evaluation system, comprising: A data receiving module, used to: receive the subject's instantaneous memory data, dementia screening data, and delayed memory data from at least one terminal; A cognitive dysfunction auxiliary evaluation module is used to obtain the cognitive dysfunction auxiliary evaluation results of the subject according to the subject's instantaneous memory data, dementia screening data, and delayed memory data using preset evaluation rules; The data output module is used to output the auxiliary evaluation results of the subject's cognitive dysfunction to at least one terminal.

[0015] It should be noted that a terminal refers to an input and output device connected to a computer system. Depending on the function, terminals can be divided into several types: smart terminals or intelligent terminals, dumb terminals, interactive terminals or online terminals. Terminals can specifically be various mobile communication devices, such as mobile phones, tablet computers, etc. This article aims to provide users with the function of inputting data and obtaining data output.

[0016] The present invention also provides an electronic device, comprising a processor and a memory storing a computer program, wherein the processor implements any one of the above-mentioned cognitive dysfunction auxiliary evaluation methods when executing the computer program.

[0017] The present invention also provides a non-transitory computer-readable storage medium having a computer program stored thereon, and when the computer program is executed by a processor, the computer program implements any of the above-mentioned cognitive dysfunction auxiliary evaluation methods.

[0018] The present invention also provides a computer program product, which includes a computer program. The computer program can be stored on a non-transitory computer-readable storage medium. When the computer program is executed by a processor, the computer can execute any of the above-mentioned cognitive dysfunction auxiliary evaluation methods.

[0019] The present invention provides a method, system, device and medium for auxiliary evaluation of cognitive dysfunction, which evaluates the subjects' instantaneous memory, dementia screening and delayed memory, wherein instantaneous memory includes instant repetition, dementia screening includes time calculation, reading, mathematical calculation, action imitation, etc., delayed memory includes delayed memory repetition without cues and delayed memory repetition with cues, etc. The overall evaluation process covers memory, execution, visual space, language, calculation and conceptual reasoning cognitive domains, etc., incorporates the characteristics of the Chinese language, and effectively assists doctors in conducting comprehensive and accurate cognitive dysfunction evaluations on subjects, greatly improving the work efficiency of medical staff. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the technical solutions in the present invention or the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0021] Figure 1 A schematic diagram of a flow chart of a method for assisting in evaluating cognitive dysfunction provided by the present invention.

[0022] Figure 2 This is a schematic diagram of the structure of a cognitive dysfunction auxiliary evaluation system provided by the present invention.

[0023] Figure 3 This is a schematic structural diagram of an electronic device provided by the present invention. DETAILED DESCRIPTION

[0024] In order to make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be clearly and completely described below in conjunction with the drawings in the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments, and they should not be understood as limitations on the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention. In the description of the present invention, it should be understood that the terms used are only for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0025] Figure 1 The flowchart of the cognitive dysfunction auxiliary evaluation method provided by the present invention is shown in FIG. The execution subject of the cognitive dysfunction auxiliary evaluation method provided by the present invention can be any applicable terminal side device or network side device, such as a cognitive dysfunction auxiliary evaluation device.

[0026] See also Figure 1 The present invention provides a method for assisting the evaluation of cognitive dysfunction, which may include: S110, receiving the subject's immediate memory data, dementia screening data, and delayed memory data.

[0027] In one embodiment, the dementia screening data includes any one of the following or any combination thereof: time calculation data, reading data, mathematical calculation data, and action imitation data, wherein the time calculation data includes date calculation data based on Chinese and / or clock calculation data, the mathematical calculation data includes any one of the following or any combination thereof: digital comparison data and / or mathematical operation data, and the action imitation data includes single action imitation data and / or series action imitation data. And, the delayed memory data includes delayed memory data without prompting cues and / or delayed memory data with prompting cues.

[0028] Specifically, the short-term memory data can be, for example, showing some objects to the subject or telling the subject the name of the object, and asking the subject to repeat the name of the object immediately. When the subject repeats correctly, he / she will be scored, and when the subject fails to repeat correctly, he / she will not be scored. The short-term memory data of the subject can be measured in this way.

[0029] Specifically, the delayed memory data can be obtained by asking the subject to recall the name of the object that needs to be repeated in the instantaneous memory test stage again after a period of time after the subject completes the instantaneous memory test. If the subject repeats correctly, he / she is scored, and if the subject fails to repeat correctly, he / she is not scored, and the delayed memory data of the subject is measured in this way. Wherein, when the subject fails to repeat correctly, the subject can be prompted with clues, and if the subject repeats correctly, he / she is scored, and if the subject fails to repeat correctly, he / she is not scored, and the delayed memory data of the subject with the prompted clues is measured in this way.

[0030] Specifically, the date calculation data based on Chinese can be obtained by asking the subject, for example, "Assuming today is the 19th, what are the days before yesterday, the day after tomorrow, and tomorrow?" If the subject calculates the date correctly, he / she will be given a score, and if the subject fails to calculate the date correctly, he / she will not be given a score. The date calculation data based on Chinese can be measured in this way.

[0031] Specifically, the clock calculation data can be obtained by showing a clock to the subject and asking the subject to express the time shown on the clock and the time that is about to arrive, such as asking the subject "What time is shown on the clock now, and how many minutes are left until the next hour", etc. When the subject correctly calculates the clock, he / she will be given a point, and when the subject fails to calculate correctly, he / she will not be given a point, and the clock calculation data of the subject is measured in this way.

[0032] Specifically, the reading data can be obtained by showing some numbers to the subject and asking the subject to read the numbers. When the subject reads correctly, he / she is given a score, and when the subject fails to read correctly, he / she is not given a score, and the reading data of the subject is measured in this way.

[0033] Specifically, the number comparison data can be obtained by showing two numbers to the subject at the same time and asking the subject to compare the sizes of the two numbers. If the subject makes a correct comparison, he / she will be given a score, and if the subject fails to make a correct comparison, he / she will not be given a score. The number comparison data of the subject can be measured in this way.

[0034] Specifically, the mathematical operation data may be a formula shown to the subject and asked to perform the calculation, the formula may be, for example, "50-2x7=?", "11-3=?", when the subject calculates correctly, he / she is given a score, when the subject fails to calculate correctly, he / she is given no score, and the mathematical operation data of the subject is measured in this way.

[0035] Specifically, the action imitation data can be a single gesture shown to the subject and asked to imitate the gesture, when the subject imitates correctly, the subject is scored, when the subject fails to imitate correctly, the subject is not scored, and so on, the single action imitation data of the subject is measured. Also, a series of gestures can be shown to the subject and asked to imitate a series of gestures, when the subject imitates correctly, the subject is scored, when the subject fails to imitate correctly, the subject is not scored, and so on, the series of action imitation data of the subject is measured.

[0036] S120. According to the subject's instantaneous memory data, dementia screening data, and delayed memory data, using preset evaluation rules, obtain the subject's cognitive dysfunction auxiliary evaluation results.

[0037] It should be noted that the subject's instantaneous memory data, dementia screening data, and delayed memory data can be the subject's instantaneous memory score data, dementia screening score data, and delayed memory score data, and can also be the result data of the subject when performing an instantaneous memory test, a dementia screening test, or a delayed memory test, such as whether the test is successfully scored, etc. When the subject's instantaneous memory data, dementia screening data, and delayed memory data are the result data of the subject when performing an instantaneous memory test, a dementia screening test, or a delayed memory test, the subject's instantaneous memory score, dementia screening score, and delayed memory score can be first obtained based on the subject's result data when performing the instantaneous memory test, the dementia screening test, and the delayed memory test, and then the preset evaluation rules can be used to obtain the subject's cognitive dysfunction auxiliary evaluation results.

[0038] The preset evaluation rules can be set according to the emphasis of the cognitive dysfunction to be evaluated. In one embodiment, the preset evaluation rules can be set to determine that the subject has cognitive dysfunction when the total score of one or more of the subject's instantaneous memory score, dementia screening score, and delayed memory score is lower than a preset threshold.

[0039] In this embodiment, 423 subjects were tested according to a cognitive dysfunction auxiliary evaluation method provided by the present invention. The clinical diagnostic criteria for dementia and mild cognitive impairment refer to PMID 25147113. According to the ROC curve, the following cut-off values ​​were calculated: total score>25.25, normal; 23.75<total score≤25.25, mild cognitive impairment; total score≤23.75, dementia. Among the 423 subjects, 275 were dementia subjects, 99 were mild cognitive impairment subjects, and 49 were cognitively normal subjects.

[0040] In one embodiment, the MMSE evaluation data and MoCA evaluation data (Montreal Cognitive Assessment) of the subject may also be obtained, and the auxiliary evaluation results of the cognitive dysfunction of the subject are respectively subjected to correlation analysis with the MMSE evaluation data and the MoCA evaluation data to verify the validity of the auxiliary evaluation results of the cognitive dysfunction of the subject.

[0041] Referring to Tables 1 and 2, this example performs Pearson correlation analysis on the cognitive dysfunction auxiliary evaluation results of the subjects with their MMSE evaluation data and MoCA evaluation data, respectively, and finds that the cognitive dysfunction auxiliary evaluation results of the cognitive dysfunction auxiliary evaluation method provided by the present invention are strongly correlated with both MMSE and MoCA (Pearson correlation coefficient with MMSE 0.862, P<0.001), (Pearson correlation coefficient with Moca 0.844, P<0.001), proving the effectiveness of the cognitive dysfunction auxiliary evaluation method provided by the present invention.

[0042]

[0043]

[0044] The present invention provides a method, system, device and medium for assisting evaluation of cognitive dysfunction. In addition to the classic instantaneous memory and delayed memory, clue prompts and recognition prompts are added to the delayed memory part, which is helpful to distinguish hippocampal memory impairment from memory impairment related to executive function. In addition, single action imitation and series action imitation are added, which are effective tools for evaluating executive function. In terms of calculation, the MMSE scale selects the classic "100-7" formula, which is easily affected by the level of education. The present invention has two calculation questions, "11-3" and "50-2*7". These two questions have small numbers, involve deduction and four arithmetic rules, and are suitable for subjects with different educational levels. In addition to simple digital calculations, the present invention also adds reading questions, comparison of size, and calculation judgment, which helps to evaluate the subject's understanding of digits and evaluate the subject's calculation, logical reasoning and language expression ability from different dimensions. The three words "the day before yesterday", "tomorrow" and "the day after tomorrow" are unique to the Chinese language. The Concord card evaluates the subject's understanding of date logical reasoning and Chinese language through these three words. Finally, adding table reading questions helps to evaluate the subject's visual space and executive function. In summary, the present invention covers the cognitive domains of memory, execution, visual-spatial, language, calculation and conceptual reasoning, incorporates the characteristics of the Chinese language, and is helpful for the comprehensive evaluation of patients with different types of cognitive impairment in China.

[0045] The cognitive dysfunction auxiliary evaluation system provided by the present invention is described below. The cognitive dysfunction auxiliary evaluation system described below and the cognitive dysfunction auxiliary evaluation method described above can be referenced to each other.

[0046] The present invention provides a cognitive dysfunction auxiliary evaluation system, comprising: A data receiving module, used to: receive the subject's instantaneous memory data, dementia screening data, and delayed memory data from at least one terminal; A cognitive dysfunction auxiliary evaluation module is used to obtain the cognitive dysfunction auxiliary evaluation results of the subject according to the subject's instantaneous memory data, dementia screening data, and delayed memory data using preset evaluation rules; The data output module is used to output the auxiliary evaluation results of the subject's cognitive dysfunction to at least one terminal.

[0047] Figure 3 An example of a physical structure diagram of an electronic device is shown in FIG. Figure 3 As shown, the electronic device may include: a processor 810, a communication interface 820, a memory 830 and a communication bus 840, wherein the processor 810, the communication interface 820 and the memory 830 communicate with each other through the communication bus 840. The processor 810 may call the logic instructions in the memory 830 to perform the following steps: receiving the subject's immediate memory data, dementia screening data, and delayed memory data from at least one terminal; According to the subject's instantaneous memory data, dementia screening data, and delayed memory data, using preset evaluation rules, the auxiliary evaluation results of the subject's cognitive dysfunction are obtained; The data output module is used to output the auxiliary evaluation results of the subject's cognitive dysfunction to at least one terminal.

[0048] In addition, the logic instructions in the above-mentioned memory 830 can be implemented in the form of a software functional unit and can be stored in a computer-readable storage medium when it is sold or used as an independent product. Based on this understanding, the technical solution of the present invention is essentially or the part that contributes to the prior art or the part of the technical solution can be embodied in the form of a software product, and the computer software product is stored in a storage medium, including a number of instructions to enable a computer device (which can be a personal computer, a server, or a network device, etc.) to perform all or part of the steps of the method described in each embodiment of the present invention. The aforementioned storage medium includes: U disk, mobile hard disk, read-only memory (ROM, Read-Only Memory), random access memory (RAM, Random Access Memory), disk or optical disk and other media that can store program codes.

[0049] On the other hand, the present invention further provides a computer program product, the computer program product comprising a computer program, the computer program can be stored on a non-transitory computer readable storage medium, and when the computer program is executed by a processor, the computer can perform the following steps: receiving the subject's immediate memory data, dementia screening data, and delayed memory data from at least one terminal; According to the subject's instantaneous memory data, dementia screening data, and delayed memory data, using preset evaluation rules, the auxiliary evaluation results of the subject's cognitive dysfunction are obtained; The data output module is used to output the auxiliary evaluation results of the subject's cognitive dysfunction to at least one terminal.

[0050] In another aspect, the present invention further provides a non-transitory computer-readable storage medium having a computer program stored thereon, which is implemented to perform the following steps when executed by a processor: receiving the subject's immediate memory data, dementia screening data, and delayed memory data from at least one terminal; According to the subject's instantaneous memory data, dementia screening data, and delayed memory data, using preset evaluation rules, the auxiliary evaluation results of the subject's cognitive dysfunction are obtained; The data output module is used to output the auxiliary evaluation results of the subject's cognitive dysfunction to at least one terminal.

[0051] The device embodiments described above are merely illustrative, wherein the units described as separate components may or may not be physically separated, and the components displayed as units may or may not be physical units, that is, they may be located in one place, or they may be distributed on multiple network units. Some or all of the modules may be selected according to actual needs to achieve the purpose of the scheme of this embodiment. Ordinary technicians in this field can understand and implement it without paying creative labor.

[0052] Through the description of the above implementation methods, those skilled in the art can clearly understand that each implementation method can be implemented by means of software plus a necessary general hardware platform, and of course, can also be implemented by hardware. Based on this understanding, the above technical solution is essentially or the part that contributes to the prior art can be embodied in the form of a software product, and the computer software product can be stored in a computer-readable storage medium, such as ROM / RAM, a disk, an optical disk, etc., including a number of instructions for a computer device (which can be a personal computer, a server, or a network device, etc.) to execute the methods described in each embodiment or some parts of the embodiments.

[0053] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A method for assisting the evaluation of cognitive impairment, characterized in that: include: Receive the subjects' immediate memory data, dementia screening data, and delayed memory data; According to the subjects' immediate memory data, dementia screening data, and delayed memory data, the preset evaluation rules are used to obtain the auxiliary evaluation results of the subjects' cognitive dysfunction.

2. The method for assisting the evaluation of cognitive impairment according to claim 1, characterized in that: Dementia screening data includes any one of the following or any combination thereof: time estimation data, reading data, mathematical calculation data, and action imitation data.

3. The method for assisting the evaluation of cognitive impairment according to claim 2, characterized in that: The time calculation data includes date calculation data and / or clock calculation data based on Chinese.

4. The method for assisting the evaluation of cognitive impairment according to claim 2, characterized in that: Mathematical calculation data includes any one of the following or any combination thereof: digital comparison data and / or mathematical operation data.

5. The method for assisting the evaluation of cognitive impairment according to claim 2, characterized in that: The motion imitation data includes single motion imitation data and / or series motion imitation data.

6. The method for assisting the evaluation of cognitive impairment according to claim 1, characterized in that: The delayed memory data includes delayed memory data without cues and / or delayed memory data with cues.

7. The method for assisting the evaluation of cognitive dysfunction according to any one of claims 1 to 6, characterized in that: The method of obtaining the auxiliary evaluation result of cognitive dysfunction of the subject based on the subject's instantaneous memory data, dementia screening data, and delayed memory data by using preset evaluation rules includes: According to the subject's immediate memory data, dementia screening data, and delayed memory data, the subject's immediate memory score, dementia screening score, and delayed memory score are obtained; According to the subjects' immediate memory scores, dementia screening scores, and delayed memory scores, the preset evaluation rules are used to obtain the auxiliary evaluation results of the subjects' cognitive dysfunction.

8. A cognitive dysfunction auxiliary evaluation system, characterized in that: include: A data receiving module, used to: receive the subject's instantaneous memory data, dementia screening data, and delayed memory data from at least one terminal; A cognitive dysfunction auxiliary evaluation module is used to obtain the cognitive dysfunction auxiliary evaluation results of the subject according to the subject's instantaneous memory data, dementia screening data, and delayed memory data using preset evaluation rules; The data output module is used to output the auxiliary evaluation results of the subject's cognitive dysfunction to at least one terminal.

9. An electronic device comprising a memory, a processor, and a computer program stored in the memory and executable on the processor, wherein: When the processor executes the program, the cognitive dysfunction auxiliary evaluation method according to any one of claims 1 to 7 is implemented.

10. A non-transitory computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, the method for assisting in assessing cognitive dysfunction as claimed in any one of claims 1 to 7 is implemented.

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