Eutrophic ion anti-inflammatory spray containing kaoliang spirit and preparation method of eutrophic ion anti-inflammatory spray

Abstract

The invention discloses an eutrophic ion anti-inflammatory spray containing kaoliang spirit and a preparation method of the eutrophic ion anti-inflammatory spray, and relates to the technical field of anti-inflammatory sprays. The Kaoliang spirit comprises the following components: Kaoliang spirit, total ginsenoside, plant polyphenol, nanosheets, polyamino acid, inorganic salt, glycosaminoglycan, a latent solvent and a propellant. The anti-inflammatory spray disclosed by the invention is a plant fiber nano water spray, does not generate stimulation or anaphylactic reaction to organisms, and has good biocompatibility; the release speed is controllable, and accurate controlled release of the plant fiber nanoparticles can be realized; the anti-inflammatory and bactericidal wound dressing has special surface properties such as low surface tension and good hydrophilicity, can form a nano-scale coating invisible to naked eyes after being sprayed on the surface of a wound, realizes long-acting anti-inflammatory and bactericidal effects, and can realize accurate contact and protection on an organism.

Description

Technical Field

[0001] The invention relates to the technical field of anti-inflammatory sprays, in particular to a nutrient-rich ion anti-inflammatory spray containing kaoliang wine and a preparation method thereof. Background Art

[0002] Pressure sores are caused by long-term pressure on local tissues, which leads to continuous ischemia, hypoxia, and malnutrition, resulting in tissue ulceration and necrosis. Skin pressure sores are a common problem in rehabilitation treatment and nursing. Literature reports that about 60,000 people die from complications of pressure sores each year. With the acceleration of population aging, it is particularly important to develop a preparation that can prevent and heal pressure sores and is easy to use.

[0003] The main methods of treating bedsores in the prior art include drug therapy and surgical treatment. Drug therapy is generally divided into antibiotic therapy and topical bactericide therapy. Commonly used bactericides include iodine compounds, silver compounds, polyhexane hydrochloride, and the like. Such drugs generally take effect slowly, cause certain irritation to the patient's wound, and are very easy to evaporate after being sprayed on the affected area, and cannot continuously have a therapeutic effect on the affected area, and frequent spraying is not conducive to wound healing. Therefore, we propose a nutrient-rich ion anti-inflammatory spray containing sorghum wine and a preparation method thereof, in order to solve the above-mentioned problems. Summary of the invention

[0004] The object of the present invention is to provide a nutrient-rich ion anti-inflammatory spray containing kaoliang wine and a preparation method thereof, so as to solve the problems in the current market raised by the above background technology.

[0005] To achieve the above-mentioned purpose, the present invention provides the following technical scheme: a nutrient-rich ion anti-inflammatory spray containing sorghum wine, comprising the following ingredients: sorghum wine, total ginsenosides, plant polyphenols, nanosheets, polyamino acids, inorganic salts, glycosaminoglycans, latent solvents and propellants.

[0006] Preferably, the weight proportions of the ingredients are: 1 to 30 parts of kaoliang wine, 1 to 20 parts of plant polyphenols, 1 to 20 parts of nanosheets, 1 to 5 parts of total ginsenosides, 1 to 5 parts of polyamino acids, 1 to 5 parts of inorganic salts, 1 to 5 parts of glycosaminoglycans, 1 to 5 parts of latent solvents and 1 to 10 parts of propellants.

[0007] Preferably, the latent solvent is one of ethanol, propylene glycol and polyethylene glycol.

[0008] Preferably, the propellant is one of hydrofluoroalkane, hydrocarbon and dimethyl ether.

[0009] Preferably, the plant polyphenols are a mixture of one or more of tea polyphenols, grape polyphenols and apple polyphenols.

[0010] The present invention also provides a method for preparing a nutrient-rich ion anti-inflammatory spray containing kaoliang wine, comprising the following steps:

[0011] S1: according to the formula, 1-30 parts of sorghum wine, 1-20 parts of plant polyphenols, 1-20 parts of nanosheets, 1-5 parts of total ginsenosides and 1-5 parts of latent solvent are added to a dry reaction bottle, and ultrasonicated in an ice-water bath for 2 hours in a high-purity nitrogen atmosphere to obtain a mixed solution 1;

[0012] S2: according to the formula, 1-5 parts of polyamino acid, 1-5 parts of inorganic salt and 1-5 parts of glycosaminoglycan are taken, added into a reaction bottle under nitrogen protection, and mixed with mixed solution 1 at room temperature for 1 hour to obtain mixed solution 2;

[0013] S3: Add 1 to 10 parts of propellant into the mixed solution 2 to obtain the spray;

[0014] S4: After the quality inspection of the spray, it is packaged into pressure-resistant containers to obtain the finished product.

[0015] Compared with the prior art, the present invention has the following beneficial effects:

[0016] The anti-inflammatory spray of the present invention is a plant fiber nano water spray, which will not cause irritation or allergic reaction to organisms and has good biocompatibility; it has a controllable release rate and can achieve precise controlled release of plant fiber nanoparticles; it has special surface properties, such as low surface tension and good hydrophilicity. After spraying on the wound surface, it can form a layer of nano-scale coating that is invisible to the naked eye, achieve long-term anti-inflammatory and bactericidal effects, and can achieve precise contact and protection of organisms.

[0017] The above summary is for illustrative purposes only and is not intended to be limiting in any way. In addition to the illustrative aspects, embodiments and features described above, further aspects, embodiments and features of the present invention will be readily apparent by reference to the following detailed description. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the preparation method of the present invention. DETAILED DESCRIPTION

[0019] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0020] See also Figure 1, a nutrient-rich ion anti-inflammatory spray containing sorghum wine, including the following ingredients: sorghum wine, total ginsenosides, plant polyphenols, nanosheets, polyamino acids, inorganic salts, glycosaminoglycans, latent solvents and propellants.

[0021] Sorghum wine helps to precipitate the active ingredients of drugs. It is a good organic solvent with good permeability. It can easily enter the tissue cells of medicinal materials, play a dissolving role, promote replacement and diffusion, and help to improve the leaching speed and effect.

[0022] Total ginsenosides are hygroscopic and have no adverse effects on the skin. They can dilate skin capillaries, promote blood circulation in the skin, and promote wound healing.

[0023] Plant polyphenols have anti-inflammatory and antibacterial effects and are non-irritating to the skin.

[0024] Polyamino acids and glycosaminoglycans can promote normal cell proliferation and also promote cell migration to a certain extent; they can promote proliferation and repair behavior; they can significantly reduce inflammatory chemokines and the content of various pro-inflammatory factors; they can significantly affect the body's immune microenvironment by affecting tissue regeneration-related pathways, including cell processes, cell growth, cell death, etc., and by changing the expression of immune and signal transduction-related proteins.

[0025] Inorganic salts can attract the water accumulated in the affected tissue and evaporate it, so they can quickly eliminate local edema, improve the degree of swelling of local tissues, and achieve the effect of alleviating swelling symptoms.

[0026] The weight proportions of the ingredients are: 1-30 parts of kaoliang wine, 1-20 parts of plant polyphenols, 1-20 parts of nanosheets, 1-5 parts of total ginsenosides, 1-5 parts of polyamino acids, 1-5 parts of inorganic salts, 1-5 parts of glycosaminoglycans, 1-5 parts of latent solvents and 1-10 parts of propellants.

[0027] The latent solvent is one of ethanol, propylene glycol and polyethylene glycol.

[0028] The propellant is one of hydrofluoroalkane, hydrocarbon and dimethyl ether.

[0029] The plant polyphenols are a mixture of one or more of tea polyphenols, grape polyphenols and apple polyphenols.

[0030] A method for preparing a nutrient-rich ion anti-inflammatory spray containing kaoliang wine comprises the following steps:

[0031] S1: according to the formula, 1-30 parts of sorghum wine, 1-20 parts of plant polyphenols, 1-20 parts of nanosheets, 1-5 parts of total ginsenosides and 1-5 parts of latent solvent are added to a dry reaction bottle, and ultrasonicated in an ice-water bath for 2 hours in a high-purity nitrogen atmosphere to obtain a mixed solution 1;

[0032] S2: according to the formula, 1-5 parts of polyamino acid, 1-5 parts of inorganic salt and 1-5 parts of glycosaminoglycan are taken, added into a reaction bottle under nitrogen protection, and mixed with mixed solution 1 at room temperature for 1 hour to obtain mixed solution 2;

[0033] S3: Add 1 to 10 parts of propellant into the mixed solution 2 to obtain the spray;

[0034] S4: After the quality inspection of the spray, it is packaged into pressure-resistant containers to obtain the finished product.

[0035] Embodiment 1

[0036] S1: Take 15 parts of sorghum wine, 10 parts of tea polyphenols, 10 parts of nanosheets, 3 parts of total ginsenosides and 3 parts of polyethylene glycol, add them into a dry reaction bottle, perform ice-water bath ultrasound for 2 hours in a high-purity nitrogen atmosphere, and obtain a mixed solution 1;

[0037] S2: Take 3 parts of polyamino acid, 3 parts of inorganic salt and 3 parts of glycosaminoglycan, add them into a reaction bottle under nitrogen protection, and mix with mixed solution 1 at room temperature for 1 hour to obtain mixed solution 2;

[0038] S3: Filling 5 parts of hydrofluoroalkane into the mixed liquid 2 by a pressure injection method or a cold filling method to obtain the spray;

[0039] S4: After the quality inspection of the spray, it is packaged into pressure-resistant containers to obtain the finished product.

[0040] Embodiment 2

[0041] S1: Take 15 parts of sorghum wine, 15 parts of grape polyphenols, 15 parts of nanosheets, 4 parts of total ginsenosides and 4 parts of propylene glycol, add them into a dry reaction bottle, perform ice-water bath ultrasound for 2 hours in a high-purity nitrogen atmosphere, and obtain a mixed solution 1;

[0042] S2: Take 4 parts of polyamino acid, 4 parts of inorganic salt and 4 parts of glycosaminoglycan, add them into a reaction bottle under nitrogen protection, and mix with mixed solution 1 at room temperature for 1 hour to obtain mixed solution 2;

[0043] S3: Filling 8 parts of hydrocarbon into the mixed liquid 2 by a pressure injection method or a cold filling method to obtain the spray;

[0044] S4: After the quality inspection of the spray, it is packaged into pressure-resistant containers to obtain the finished product.

[0045] Embodiment 3

[0046] S1: Take 20 parts of sorghum wine, 10 parts of apple polyphenols, 5 parts of nanosheets, 3 parts of total ginsenosides and 3 parts of ethanol, add them into a dry reaction bottle, perform ice water bath ultrasound for 2 hours in a high-purity nitrogen atmosphere, and obtain a mixed solution 1;

[0047] S2: Take 3 parts of polyamino acid, 3 parts of inorganic salt and 3 parts of glycosaminoglycan, add them into a reaction bottle under nitrogen protection, and mix with mixed solution 1 at room temperature for 1 hour to obtain mixed solution 2;

[0048] S3: Fill 5 parts of dimethyl ether into the mixed solution 2 by pressure injection or cold filling to obtain the spray;

[0049] S4: After the quality inspection of the spray, it is packaged into pressure-resistant containers to obtain the finished product.

[0050] Embodiment 4

[0051] S1: Take 20 parts of sorghum wine, 10 parts of tea polyphenols, 2 parts of nanosheets, 2 parts of total ginsenosides and 2 parts of polyethylene glycol, add them into a dry reaction bottle, perform ice water bath ultrasound for 2 hours in a high-purity nitrogen atmosphere, and obtain a mixed solution 1;

[0052] S2: Take 2 parts of polyamino acid, 2 parts of inorganic salt and 2 parts of glycosaminoglycan, add them into a reaction bottle under nitrogen protection, and mix with mixed solution 1 at room temperature for 1 hour to obtain mixed solution 2;

[0053] S3: Filling 5 parts of hydrofluoroalkane into the mixed liquid 2 by a pressure injection method or a cold filling method to obtain the spray;

[0054] S4: After the quality inspection of the spray, it is packaged into pressure-resistant containers to obtain the finished product.

[0055] In order to further illustrate the effect of the present invention, the applicant used the nutrient-rich ion anti-inflammatory spray containing sorghum wine prepared in the above-mentioned Examples 1 to 4 and the existing iodine compounds, silver compounds, and polyhexylbiguanide bactericides for seven patients with the same conditions (the same conditions here refer to: the gender is male, the age is 55-60 years old, there is no significant difference in the basic physical conditions, the area of ​​the pressure sores and the degree of the pressure sores are not significantly different, all of which are the third stage, the shallow ulcer stage), to treat the pressure sores, and recorded the condition of the patient's wound every day for one week. The specific situation is as follows:

[0056]

[0057] It can be seen from the above table that the therapeutic effect and healing speed of the nutrient-rich ion anti-inflammatory spray containing sorghum wine prepared by the present invention are better than those of the prior art.

[0058] The contents not described in detail in this specification belong to the prior art known to professional and technical personnel in this field.

[0059] Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments, or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A nutrient-rich ion anti-inflammatory spray containing sorghum wine, characterized in that: The invention comprises the following ingredients: sorghum wine, total ginsenosides, plant polyphenols, nanosheets, polyamino acids, inorganic salts, glycosaminoglycans, latent solvents and propellants.

2. The nutrient-rich ion anti-inflammatory spray containing kaoliang wine according to claim 1, characterized in that: The weight proportions of the ingredients are: 1-30 parts of kaoliang wine, 1-20 parts of plant polyphenols, 1-20 parts of nanosheets, 1-5 parts of total ginsenosides, 1-5 parts of polyamino acids, 1-5 parts of inorganic salts, 1-5 parts of glycosaminoglycans, 1-5 parts of latent solvents and 1-10 parts of propellants.

3. The nutrient-rich ion anti-inflammatory spray containing kaoliang wine according to claim 1, characterized in that: The latent solvent is one of ethanol, propylene glycol and polyethylene glycol.

4. The nutrient-rich ion anti-inflammatory spray containing kaoliang wine according to claim 1, characterized in that: The propellant is one of hydrofluoroalkane, hydrocarbon and dimethyl ether.

5. The nutrient-rich ion anti-inflammatory spray containing kaoliang wine according to claim 1, characterized in that: The plant polyphenols are a mixture of one or more of tea polyphenols, grape polyphenols and apple polyphenols.

6. A method for preparing a nutrient-rich ion anti-inflammatory spray containing kaoliang wine as claimed in any one of claims 1 to 5, characterized in that: The steps include: S1: according to the formula, 1-30 parts of sorghum wine, 1-20 parts of plant polyphenols, 1-20 parts of nanosheets, 1-5 parts of total ginsenosides and 1-5 parts of latent solvent are added to a dry reaction bottle, and ultrasonicated in an ice-water bath for 2 hours in a high-purity nitrogen atmosphere to obtain a mixed solution 1; S2: according to the formula, 1-5 parts of polyamino acid, 1-5 parts of inorganic salt and 1-5 parts of glycosaminoglycan are taken, added into a reaction bottle under nitrogen protection, and mixed with mixed solution 1 at room temperature for 1 hour to obtain mixed solution 2; S3: Add 1 to 10 parts of propellant into the mixed solution 2 to obtain the spray; S4: After the quality inspection of the spray, it is packaged into pressure-resistant containers to obtain the finished product.

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