Medicament emulsifying device

Abstract

The invention relates to the technical field of medicament emulsification, in particular to a medicament emulsification device. According to the device, the porous baffle, the stirring assembly and the ultrasonic vibration assembly are combined, so that efficient emulsification of a medicament is realized. The emulsifying tank is divided into an upper chamber and a lower chamber by the porous baffle, so that the layering treatment of liquid is promoted, and the mixing effect is enhanced. The stirring assembly of the upper chamber effectively promotes liquid mixing, and the ultrasonic vibration assembly of the lower chamber further refines particles, so that the emulsification efficiency is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of pharmaceutical emulsification, and specifically to a pharmaceutical emulsification device. Background Art

[0002] Pharmaceutical emulsification is an indispensable part of many industrial processes, and its effectiveness directly determines the effectiveness of raw material treatment, product preparation and subsequent applications. In this process, if the pharmaceutical emulsification is not sufficient, a series of chain reactions will be triggered, not only causing serious waste of pharmaceutical resources, but also having a profound negative impact on subsequent process links. Therefore, it is particularly important to improve the degree of pharmaceutical emulsification.

[0003] Currently, the commonly used methods to improve the emulsification degree include mechanical stirring method, ultrasonic emulsification method and static mixer emulsification method. The mechanical stirring method is widely used because of its simple operation, but its emulsification speed is slow, usually requiring a long time to complete emulsification, which leads to a time-consuming and inefficient process and cannot meet the current demand for rapid emulsification in production. The ultrasonic emulsification technology has attracted attention due to its environmental protection, cost-effectiveness and energy-saving advantages. It can generate high shear force, shock waves and microjets, effectively decompose and form smaller emulsified particles; however, when facing larger emulsified particles, it takes a long time to decompose the larger emulsified particles into smaller particles at the beginning, and then further decompose the smaller particles.

[0004] It can be seen that the above emulsification devices all have certain limitations in the process of use and cannot quickly and effectively complete the pharmaceutical emulsification process. Therefore, it is urgent to develop a new type of emulsification device to meet the requirements of modern industrial production. Summary of the Invention

[0005] In order to avoid and overcome the technical problems existing in the prior art, the present invention provides a pharmaceutical emulsification device. The present invention can quickly and effectively emulsify the pharmaceutical, thereby improving the degree of pharmaceutical emulsification.

[0006] To achieve the above object, the present invention provides the following technical solutions:

[0007] As a further scheme of the present invention: it includes an emulsification tank with liquid inlet at the top and liquid outlet at the bottom. A porous baffle is installed in the emulsification tank, and the porous baffle divides the tank cavity of the emulsification tank into an upper chamber and a lower chamber; a stirring component for stirring the pharmaceutical is installed in the upper chamber, and a spiral guide vane coaxially installed on the chamber wall and cooperating with the porous baffle to form a turbulence element; an ultrasonic vibration component for ultrasonic decomposition of the pharmaceutical is installed in the lower chamber; the emulsification efficiency of the emulsification device is E, and the specific calculation formula is as follows:

[0008] E = k × F s α × I cβ ×T γ ×(t 1 +t 2 ) δ ;

[0009] In the formula, k represents the basic proportional coefficient of emulsification efficiency; F S represents the shear force generated by the stirring component; α is the stirring shear force influence index; I c represents the cavitation effect intensity generated by the ultrasonic vibration component; β is the ultrasonic cavitation effect influence index; T represents the turbulence intensity generated by the flow disturbing element; γ is the flow disturbing turbulence intensity influence index; t 1 represents the residence time of the medicament in the upper chamber; t 2 represents the residence time of the medicament in the upper chamber; δ is the chamber residence time influence index.

[0010] As a further solution of the present invention: The stirring component includes a stirring shaft rotatably installed coaxially in the emulsifying tank, and a plurality of groups of stirring blades are fixedly installed on the shaft body of the stirring shaft extending into the upper chamber.

[0011] As a further solution of the present invention: Each stirring blade in the same group is evenly arranged circumferentially around the stirring shaft in sequence, and each group of stirring blades is arranged at equal intervals axially along the stirring shaft.

[0012] As a further solution of the present invention: Each strip-shaped spiral guide vane is evenly distributed circumferentially around the emulsifying tank at equal intervals on the inner wall surface of the upper chamber, so that the inner wall surface is spiral.

[0013] As a further solution of the present invention: The diversion holes on the porous baffle are evenly distributed.

[0014] As a further solution of the present invention: The ultrasonic vibration component includes an ultrasonic transducer installed at the center of the lower chamber and an ultrasonic generator installed on the inner wall surface of the lower chamber.

[0015] As a further solution of the present invention: There are two groups of ultrasonic generators, and their ultrasonic emission directions are opposite to each other.

[0016] As a further solution of the present invention: A concentration sensor for detecting the concentration of the medicament is also arranged in the lower chamber.

[0017] As a further solution of the present invention: A motor is fixedly installed on the top of the emulsifying tank, and the motor is in transmission connection with the stirring shaft.

[0018] As a further solution of the present invention: A plurality of elastic support feet are installed on the bottom of the emulsifying tank, and the elastic support feet are evenly arranged in sequence around the circumferential direction of the emulsifying tank; the elastic support feet include support blocks installed on the bottom of the emulsifying tank, a guiding counterbore vertically arranged axially is opened on the bottom surface of the support block, a support rod is axially slidably inserted in the guiding counterbore, and a shock-absorbing spring is compressively installed between the support rod and the bottom of the guiding counterbore.

[0019] Compared with the prior art, the beneficial effects of the present invention are:

[0020] 1. By combining the porous baffle, the stirring assembly and the ultrasonic vibration assembly, the present device realizes the efficient emulsification of the medicament. The porous baffle divides the emulsifying tank into upper and lower chambers, which not only promotes the liquid stratification treatment, but also enhances the mixing effect. The stirring assembly in the upper chamber effectively promotes the liquid mixing, while the ultrasonic vibration assembly in the lower chamber further refines the particles and improves the emulsification efficiency.

[0021] 2. The stirring assembly includes a stirring shaft coaxially and rotatably installed in the emulsifying tank and multiple groups of stirring blades. The stirring shaft drives the multiple groups of stirring blades to rotate, which can fully stir the medicament and promote the fusion of the medicament, laying a good foundation for the subsequent emulsification process. Through the uniform arrangement in the circumferential and axial directions, the stirring blades can cover the entire upper chamber to ensure dead-free stirring, further improving the mixing efficiency and uniformity, which is a key link to improve the emulsification quality.

[0022] 3. The spiral guide vanes not only increase the flow path of the medicament, but also form a strong turbulence effect, effectively improving the emulsification efficiency.

[0023] 4. The ultrasonic transducers and ultrasonic generators installed in the lower chamber decompose and emulsify the medicament at the microscopic level through the vibration of ultrasonic waves, significantly improving the emulsification effect and the utilization rate of the medicament.

[0024] 5. The two groups of oppositely arranged ultrasonic generators can form an opposing ultrasonic field, further enhancing the emulsification effect of ultrasonic waves and improving the processing efficiency and effect.

[0025] 6. Through the cooperation of the shock-absorbing spring and the support rod, the vibration and impact generated during the emulsification process are effectively absorbed, protecting the equipment from damage, extending the service life, reducing the noise pollution at the same time, and improving the safety and comfort of the working environment. Description of the Drawings

[0026] Figure 1 It is a schematic diagram of the overall structure of the present invention.

[0027] Figure 2 It is a schematic diagram of the structure of the porous baffle in the present invention.

[0028] In the figure: 1. Emulsifying tank; 101. Upper chamber; 102. Lower chamber; 2. Motor; 3. Feed inlet; 4. Stirring shaft; 5. Stirring blades; 6. Porous baffle; 61. Flow guiding holes; 7. Ultrasonic generator; 8. Ultrasonic transducer; 9. Elastic support feet; 91. Support blocks; 911. Guide counterbores; 92. Support rods; 93. Shock-absorbing springs; 10. Concentration sensor; 11. Discharge outlet; 12. Intelligent controller; 15. Spiral flow guiding vanes. Specific embodiments

[0029] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0030] Please refer to Figure 1 and Figure 2 In the embodiments of the present invention, the emulsifying device is divided into a multi-stage emulsifying chamber module, a flow disturbing element, a power system module, and a sensor and control module. The corresponding modules are completed step by step, and finally the various modules are integrated together to complete the design. The following will introduce each module in detail.

[0031] The multi-stage emulsifying chamber module is composed of two vertically connected cylindrical upper chamber 101 and lower chamber 102 in series. The chamber walls are made of corrosion-resistant alloy materials, and the two chambers are separated by a porous baffle 6.

[0032] The flow disturbing element includes spiral flow guiding vanes 15 and a porous baffle 6. The spiral flow guiding vanes 15 are spiral-shaped, and their pitch and height are designed according to the size of the chamber and the required emulsifying effect. The porous baffle 6 is circular, and a plurality of flow guiding holes 61 are evenly distributed on it. The spiral flow guiding vanes 15 are tightly connected to the inner wall of the upper chamber 101, and the porous baffle 6 is fixed on the inner wall between the upper chamber 101 and the lower chamber 102. When the medicament flows through the upper chamber 101, the spiral flow guiding vanes 15 guide the fluid to form a spiral flow, increasing the turbulence degree of the fluid and making the medicament mix better. The porous baffle 6 further disrupts the flow direction of the fluid, so that the medicament particles are subjected to a shearing force when passing through the small holes, promoting emulsification.

[0033] The power system module consists of a motor 2, a stirring assembly, and an ultrasonic vibration assembly. The stirring assembly includes a stirring shaft 4 and stirring blades 5. The stirring shaft 4 is cylindrical and runs through the exact center of the upper chamber 101. The stirring blades 5 are arc-shaped and evenly distributed on the stirring shaft 4, with a quantity of 3. The ultrasonic vibration assembly consists of an ultrasonic generator 7 and an ultrasonic transducer 8. The ultrasonic generator 7 is cuboid-shaped and installed on both sides of the lower chamber 102. The ultrasonic transducer 8 is cylindrical and installed at the exact center of the bottom of the lower chamber 102. The stirring shaft 4 is connected to the outer shell of the emulsifying tank 1 through a bearing. The inner diameter of the bearing matches the outer diameter of the stirring shaft 4, enabling free rotation. The ultrasonic transducer 8 is connected to the chamber wall through a sealing connector, which ensures that ultrasonic energy can be effectively transmitted into the lower chamber 102. When the motor 2 starts, it drives the mechanical stirring assembly, and then the rotation of the stirring shaft 4 drives the stirring blades 5 to stir the medicament, generating a shear force to break the medicament particles. The ultrasonic vibration assembly generates ultrasonic signals by the ultrasonic generator 7, converts electrical energy into mechanical energy through the ultrasonic transducer 8 to generate ultrasonic vibrations, and utilizes the cavitation effect to refine the medicament particles. The two power modes work together to accelerate the emulsification process.

[0034] The sensor and control system module includes a high-precision concentration sensor 10 and an intelligent controller 12. The concentration sensor 10 is cylindrical and installed on the left side of the ultrasonic transducer 8; the intelligent controller 12 is rectangular and installed on the outer wall of the emulsifying tank 1 in the upper chamber 101. The concentration sensor 10 continuously monitors the medicament concentration during the emulsification process and transmits the data to the intelligent controller 12. The intelligent controller 12 adjusts the operating parameters of the power system module according to the preset algorithms and parameter ranges to ensure the stability of the emulsification quality.

[0035] A plurality of elastic support feet 9 are installed on the bottom of the emulsifying tank 1, and the elastic support feet 9 are evenly arranged circumferentially around the emulsifying tank 1 in sequence; the elastic support feet 9 include a support block 91 installed on the bottom of the emulsifying tank 1. A guiding counterbore 911 arranged vertically axially is formed on the bottom surface of the support block 91. A support rod 92 is axially and slidably inserted into the guiding counterbore 911, and a shock-absorbing spring 93 is compressively installed between the support rod 92 and the bottom of the guiding counterbore 911. Through the cooperation of the shock-absorbing spring 93 and the support rod 92, the vibrations and impacts generated during the emulsification process are effectively absorbed, protecting the equipment from damage, extending its service life, reducing noise pollution, and improving the safety and comfort of the working environment.

[0036] The usage method of the present invention is as follows: First, inject the medicament into the upper chamber 101 of the multi-stage emulsification chamber module through the feed port 3 according to a certain ratio. Then, start the power system module, the stirring assembly, and the ultrasonic vibration assembly to start working. During the emulsification process, the sensor and the control system module monitor various parameters in real time and adjust the operating parameters of the power system module as needed. The operator can understand the situation of the emulsification process at any time through the intelligent controller 12 and make necessary interventions. When the emulsification reaches the preset requirements, collect the emulsified medicament from the discharge port 11, and then turn off the power system module to complete the emulsification process.

[0037] The present invention realizes the efficient emulsification of the medicament through the synergistic effect of the above-mentioned various modules. On this basis, we further conduct an in-depth analysis of its emulsification principle and derive a formula related to the emulsification efficiency to better understand the influence of various factors on the emulsification process. First, analyze the various factors that affect the emulsification efficiency in the device. The shear force F generated by the stirring assembly s is an important factor in breaking the medicament particles, and the cavitation effect intensity I generated by the ultrasonic vibration assembly c plays a key role in refining the medicament particles. The turbulence intensity T generated by the flow disturbance element can promote the mixing of the medicament. The residence time t of the medicament in each stage of the emulsification chamber 1 and t 2 will also affect the emulsification effect. The following is the new formula and theoretical analysis part:

[0038] Let the emulsification efficiency of the medicament in this device be E, which is related to the shear force F generated by the stirring assembly S , the cavitation effect intensity I generated by the ultrasonic vibration assembly c , the turbulence intensity T generated by the flow disturbance element, the residence time t of the medicament in each stage of the emulsification chamber 1 , t 2 (corresponding to the first chamber and the second chamber respectively). Finally, the following equation is obtained:

[0039] E = k × F s α × I c β × T γ × (t 1 + t 2 ) δ

[0040] where k is the basic proportionality coefficient of the emulsification efficiency;

[0041] α is the influence index of the stirring shear force;

[0042] β is the influence index of the ultrasonic cavitation effect;

[0043] γ is the influence index of the flow disturbance turbulence intensity;

[0044] δ is the chamber residence time influence index.

[0045] The shear force F generated by the stirring assembly S : The rotation of the stirring shaft 4 drives the stirring blades 5 to stir the medicament, generating a shear force to break the medicament particles. The magnitude of the stirring force is related to factors such as the rotation speed of the stirring shaft 4, the shape and number of the stirring blades 5. When the stirring force increases, that is, when F S increases, more medicament particles are broken, which is beneficial to the emulsification process. Therefore, E is positively correlated with F S , that is, α>0 (α reflects the sensitivity of the shear force generated by the stirring assembly to the emulsification efficiency).

[0046] The cavitation effect intensity I generated by the ultrasonic vibration assembly c : The ultrasonic generator 7 generates ultrasonic signals, which are converted into mechanical energy by the ultrasonic transducer 8 to generate ultrasonic vibrations. The cavitation effect is used to refine the medicament particles. The stronger the cavitation effect, the better the refinement effect of the medicament particles and the higher the emulsification efficiency. Therefore, when I c increases, E also increases, that is, β>0 (β reflects the degree of influence of the cavitation effect intensity generated by the ultrasonic vibration assembly on the emulsification efficiency).

[0047] The turbulence intensity T generated by the flow disturbing element: The spiral guide vane 15 guides the fluid to form a spiral flow, increasing the turbulence degree of the fluid. The porous baffle 6 further disrupts the flow direction of the fluid, so that the medicament particles are subjected to shear force when passing through the small holes, promoting emulsification. The greater the turbulence intensity, the more intense the mixing and collision between the medicament particles, and the better the emulsification effect. Therefore, when T increases, E increases, that is, γ>0 (γ represents the weight of the turbulence intensity generated by the flow disturbing element on the emulsification efficiency).

[0048] The residence time t of the medicament in each stage of the emulsification chamber 1 , t 2 : The longer the residence time of the medicament in the chamber, the longer the time it is subjected to various emulsification effects, and the better the emulsification effect. Therefore, when (t 1 + t 2 ) increases, E increases, that is, δ>0 (δ measures the importance of the residence time of the medicament in each stage of the emulsification chamber on the emulsification efficiency).

[0049] Example 1:

[0050] In a food processing factory, when producing a certain sauce, it is necessary to emulsify the raw materials to obtain a delicate and uniform texture and a stable texture. The traditional emulsification method has problems such as slow emulsification speed and unstable effect, so the device of this application is used for emulsification.

[0051] 1. Basic data:

[0052] It is known that during the emulsification process of the sauce, the basic proportionality coefficient of emulsification efficiency k = 0.2, the influence index of stirring shear force α = 0.7, the influence index of ultrasonic cavitation effect β = 0.5, the influence index of turbulent flow intensity γ = 0.4, and the influence index of chamber residence time δ = 0.6.

[0053] 2. Emulsification efficiency:

[0054] The shear force F generated by the stirring component S = 7, the cavitation effect intensity I generated by the ultrasonic vibration component c = 5, and the turbulent flow intensity T generated by the turbulence element = 4.

[0055] The residence time t of the medicament (sauce) in the first chamber 1 = 3 minutes, and the residence time t in the second chamber 2 = 1.5 minutes.

[0056]

[0057] Thus, it can be seen that the emulsification efficiency of the sauce is 6.9317.

[0058] Example 2:

[0059] A certain cosmetics enterprise faced problems such as low emulsification efficiency and uneven emulsion particle size during the production of emulsion, which affected the appearance and usage effect of the product. Therefore, the device of the present invention was used for emulsion emulsification.

[0060] 1. Basic data:

[0061] It is known that during the emulsification process of the emulsion, the basic proportionality coefficient of emulsification efficiency k = 0.3, the influence index of stirring shear force α = 0.6, the influence index of ultrasonic cavitation effect β = 0.3, the influence index of turbulent flow intensity γ = 0.3, and the influence index of chamber residence time δ = 0.5.

[0062] 2. Emulsification efficiency:

[0063] The shear force F generated by the stirring component S = 8, the cavitation effect intensity I generated by the ultrasonic vibration component c = 6, and the turbulent flow intensity T generated by the turbulence element = 4.

[0064] The residence time t of the medicament (sauce raw material) in the first chamber 1 = 3 minutes, and the residence time t in the second chamber 2 = 2 minutes.

[0065]

[0066] Thus, it can be seen that the emulsification efficiency of the emulsion is 6.6622.

[0067] As described above, it is only a preferred specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present invention, according to the technical solution and inventive concept of the present invention, making equivalent substitutions or changes, shall be covered by the protection scope of the present invention.

Claims

1. A pharmaceutical emulsification device, characterized in that: The invention comprises an emulsification tank (1) with a liquid inlet at the top and a liquid outlet at the bottom. A porous baffle (6) is installed in the emulsification tank (1), and the porous baffle (6) divides the tank cavity of the emulsification tank (1) into an upper chamber (101) and a lower chamber (102). The upper chamber (101) is provided with a stirring component for stirring the medicine, and a spiral guide plate (15) coaxially installed on the chamber wall and cooperating with the porous baffle (6) to form a spoiler element. The lower chamber (102) is provided with an ultrasonic vibration component for ultrasonically decomposing the medicine. The emulsification efficiency of the emulsification device is E, and the specific calculation formula is as follows: E=k×F s α ×I c β ×T γ ×(t1+t2) δ ; In the formula, k represents the basic proportional coefficient of emulsification efficiency; F S It represents the shear force generated by the stirring component; α is the stirring shear force influence index; I c represents the intensity of the cavitation effect generated by the ultrasonic vibration component; β is the influence index of the ultrasonic cavitation effect; T represents the turbulence intensity generated by the spoiler element; γ is the influence index of the spoiler turbulence intensity; t1 represents the time that the agent stays in the upper chamber (101); t2 represents the time that the agent stays in the upper chamber (101); δ is the influence index of the chamber residence time.

2. A pharmaceutical emulsification device according to claim 1, characterized in that: The stirring assembly comprises a stirring shaft (4) coaxially rotatably mounted in the upper chamber (101), and a plurality of groups of stirring blades (5) are fixedly mounted on the shaft body of the stirring shaft (4).

3. A pharmaceutical emulsification device according to claim 2, characterized in that: Each group of stirring blades (5) is arranged in sequence at equal intervals along the axial direction of the stirring shaft (4), and each stirring blade (5) in the same group is evenly arranged in sequence around the circumference of the stirring shaft (4).

4. A pharmaceutical emulsification device according to any one of claims 1 to 3, characterized in that: The strip-shaped spiral guide plates (15) are evenly distributed on the inner wall surface of the upper chamber (101) at equal intervals in the circumferential direction of the emulsification tank (1), so that the inner wall surface is spiral.

5. A pharmaceutical emulsification device according to claim 4, characterized in that: The flow guide holes (61) on the porous baffle (6) are evenly distributed.

6. A pharmaceutical emulsification device according to claim 5, characterized in that: The ultrasonic vibration component comprises an ultrasonic transducer (8) installed at the center of the lower chamber (102), and an ultrasonic generator (7) installed on the inner wall surface of the lower chamber (102).

7. A pharmaceutical emulsification device according to claim 6, characterized in that: The ultrasonic generators (7) are in two groups, and their ultrasonic emission directions are opposite to each other.

8. A pharmaceutical emulsification device according to claim 7, characterized in that: A concentration sensor (10) for detecting the concentration of the drug is also arranged in the lower chamber (102).

9. The pharmaceutical emulsification device according to claim 8, characterized in that: A motor (2) is fixedly mounted on the top of the emulsification tank (1), and the motor (2) is drivingly connected to a stirring shaft (4).

10. The pharmaceutical emulsification device according to claim 9, characterized in that: A plurality of elastic support feet (9) are installed on the bottom of the emulsification tank (1), and each elastic support foot (9) is evenly arranged in sequence around the circumference of the emulsification tank (1); the elastic support foot (9) comprises a support block (91) installed at the bottom of the emulsification tank (1), an axially vertically arranged guide countersunk hole (911) is provided on the bottom surface of the support block (91), a support rod (92) is axially slidably inserted in the guide countersunk hole (911), and a shock-absorbing spring (93) is compressed and installed between the support rod (92) and the bottom of the guide countersunk hole (911).

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