Liquid adhesive bandage and preparation method thereof

Abstract

The invention relates to the technical field of medical dressings, in particular to a liquid adhesive bandage and a preparation method thereof.The preparation method comprises the following steps that according to the formula amount, sodium chloride and sodium citrate are added into water, and a mixture A is obtained; adding copper gluconate into the mixture A to form a mixture B; mixing Tween 20 with glycerin, adding L-menthol, and stirring to form a mixture C; adding the mixture C into the mixture B to form a mixture D; the preparation method comprises the following steps: adding acetic acid into water, uniformly mixing, adding chitosan, and dissolving to obtain a chitosan-acetic acid solution; adding a chitosan-acetic acid solution into the mixture D, and dissolving to form a mixture E; adjusting the pH value of the mixture E to 4.5-6.5, filtering, filling and sterilizing to obtain the liquid adhesive bandage. The prepared liquid adhesive bandage can quickly form a layer of protective film on the surface of a wound, effectively inhibits growth of bacteria and promotes wound healing, and meanwhile, the liquid adhesive bandage has good flexibility and comfort and small irritation.

Description

Technical Field

[0001] The present invention relates to the technical field of medical dressings, and particularly relates to a liquid band-aid and a preparation method thereof. Background Art

[0002] Traditional band-aids are usually in sheet form and consist of a water-absorbing layer, an adhesive layer, and an isolation layer. Although widely used in daily life, they have some deficiencies. For example, the fit of traditional band-aids is limited and they are likely to fall off at movable parts such as joints, unable to effectively maintain the coverage and protection of the wound; moreover, their air permeability is poor, and long-term use may cause the skin around the wound to be stuffy, humid, breed bacteria, and affect wound healing.

[0003] Currently, there are also some liquid band-aid products on the market, but most of them need to use ethanol as a solvent, which has the problem of strong skin irritation.

[0004] In view of this, how to provide a liquid band-aid with less skin irritation is a technical problem that needs to be solved urgently at present. Summary of the Invention

[0005] In order to solve the problem of strong skin irritation of liquid band-aids in the prior art, the present invention provides a preparation method of a liquid band-aid. This preparation method provides a liquid band-aid with a non-ethanol solvent system, which improves the antibacterial performance and rapid film-forming performance while reducing skin irritation, and solves the problem of strong skin irritation of liquid band-aids in the prior art.

[0006] The technical solution adopted by the present invention to solve its technical problems is as follows: A preparation method of a liquid band-aid, comprising the following steps: S1: According to the formula amount, add sodium chloride and sodium citrate to water, dissolve to obtain mixture A; S2: Add copper gluconate to mixture A to form mixture B; S3: Mix Tween 20 and glycerol, add L-menthol, and stir to form mixture C; S4: Add the mixture C to the mixture B to form mixture D; S5: Add acetic acid to water, mix well and then add chitosan, dissolve to obtain a chitosan-acetic acid solution; S6: Add the chitosan-acetic acid solution to the mixture D, dissolve to form mixture E; S7: Adjust the pH value of the mixture E to 4.5 - 6.5, filter, fill, and sterilize to obtain the liquid band-aid.

[0007] Optionally, according to parts by weight, the addition amount of the sodium chloride in step S1 is 0.5 - 1.5 parts.

[0008] Optionally, based on parts by weight, the addition amount of sodium citrate described in step S1 is 0.2 - 1.5 parts.

[0009] Optionally, based on parts by weight, the addition amount of copper gluconate described in step S2 is 0.01 - 0.5 parts.

[0010] Optionally, based on parts by weight, the addition amount of L-menthol described in step S3 is 0.1 - 2 parts.

[0011] Optionally, based on parts by weight, the addition amount of glycerol described in step S3 is 3 - 15 parts.

[0012] Optionally, based on parts by weight, the addition amount of Tween 20 described in step S3 is 0.4 - 3 parts.

[0013] Optionally, based on parts by weight, the addition amount of acetic acid described in step S5 is 0.5 - 3 parts.

[0014] Optionally, based on parts by weight, the addition amount of chitosan described in step S5 is 1 - 3 parts.

[0015] Another object of the present invention is to provide a liquid band-aid, which is prepared by the preparation method of the liquid band-aid as described above.

[0016] The beneficial effects of the present invention are as follows: The preparation method of the liquid band-aid provided by the present invention can rapidly form a protective film on the wound surface, effectively inhibit the growth of bacteria, promote wound healing, and at the same time has good flexibility and comfort, with little irritation, solving the problems of weak antibacterial performance, strong irritation, slow film formation, etc. existing in the existing band-aids. Detailed Description of the Invention

[0017] The present invention will now be further described in detail. The embodiments described below are exemplary and are intended to explain the present invention, and should not be construed as limiting the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts fall within the scope of protection of the present invention.

[0018] To solve the problem of strong skin irritation of the liquid band-aid in the prior art, the present invention provides a preparation method of a liquid band-aid, which comprises the following steps: S1: According to the formulation amount, add sodium chloride and sodium citrate to water, and through operations such as stirring / ultrasonic treatment until completely dissolved to obtain mixture A; S2: Slowly add copper gluconate to mixture A, and through operations such as stirring / ultrasonic treatment to fully dissolve copper gluconate in the solution to form mixture B; S3: Mix Tween 20 and glycerol evenly, add L-menthol, and stir well to form mixture C; S4: Slowly add mixture C into mixture B, and through operations such as stirring / ultrasonic treatment, etc., fully mix each component to form mixture D; S5: Add acetic acid into water, mix evenly and then add chitosan, and dissolve it through operations such as stirring / ultrasonic treatment, etc., to obtain a chitosan-acetic acid solution; S6: Slowly add the chitosan-acetic acid solution into mixture D, and through operations such as stirring / ultrasonic treatment, etc., ensure that chitosan is completely dissolved and evenly dispersed to form mixture E; S7: Use acetic acid solution or sodium citrate to adjust the pH value of mixture E to 4.5 - 6.5, preferably adjust it to 5.0 - 5.8, filter, fill, and sterilize to obtain a liquid wound dressing.

[0019] The preparation method of the liquid wound dressing has the following mechanism of action: 1. Chitosan dissolution and system stability: (1) Amino protonation for solubilization: The amino group (-NH2) in the chitosan molecule is protonated to form a positively charged ammonium group (-NH3 ⁺ ) in acetic acid solution, and the hydrogen bond network between molecular chains is destroyed through charge repulsion to achieve the dissolution of chitosan.

[0020] (2) Formation of ionic crosslinking network: Gluconate (C 12 H 21 O 14 - ) and protonated chitosan (-NH3 ⁺ ) form a dynamic ionic crosslinking network through electrostatic interaction, improving the solution homogeneity and film-forming stability, and preventing chitosan from precipitating due to pH fluctuations.

[0021] (3) Chelation: Chitosan is positively charged (-NH3 ⁺ ) in acidic solution. If it directly contacts Cu 2+ , electrostatic adsorption will occur, leading to agglomeration. After citrate ions (C6H5O7 3- ) chelate Cu²⁺, the positive charge is neutralized to ensure the homogeneity and stability of the system.

[0022] (4) pH regulation: Sodium citrate and acetic acid form a buffer system to maintain the pH at 4.5 - 6.5 (preferably the pH value is 5.0 - 5.8), which not only ensures the dissolution of chitosan but also avoids excessive acidification from irritating the skin. At the same time, it can prevent Cu 2+ from being inactivated under overly acidic or alkaline conditions.

[0023] 2. Antibacterial synergistic effect (charge-coordinated antibacterial): (1) Antibacterial mechanism of chitosan: A. Charge adsorption: Chitosan is positively charged (-NH3 ⁺ ) and binds to the bacterial cell membrane (negatively charged) through electrostatic interaction, disrupting membrane permeability.

[0024] B. Membrane damage: After chitosan penetrates into the cell, it interferes with DNA / RNA transcription and protein synthesis.

[0025] (2) Antibacterial mechanism of Cu²⁺: A. Generation of reactive oxygen species (ROS): Cu²⁺ generates hydroxyl radicals (·OH) through the Fenton reaction, oxidatively damaging cell membranes, proteins, and nucleic acids.

[0026] B. Enzyme activity inhibition: It binds to the sulfhydryl groups (-SH) in microbial enzymes, blocking metabolic pathways.

[0027] (3) Synergistic enhancement effect: The positive charge (-NH3 ⁺ ) of chitosan adsorbs on the bacterial surface. After disrupting the cell membrane barrier, Cu²⁺ can more easily enter the cell, amplifying the generation of ROS and the enzyme inhibition effect.

[0028] 3. Optimization of film-forming properties: (1) Glycerol-Tween 20 synergistic plasticization: A. Glycerol binds to the chitosan molecular chain through hydrogen bonds, reducing the glass transition temperature and enhancing the film flexibility; B. Tween 20 reduces the surface tension of the solution, promotes the uniform spreading of the liquid on the wound surface, and shortens the film-forming time to 2 - 4 minutes.

[0029] (2) Osmotic pressure adaptation: Sodium chloride adjusts the solution osmotic pressure to 280 - 320 mOsm / kg (similar to human tissue fluid), reducing the osmotic stress on wound surface cells and improving the use comfort.

[0030] (3) Enhancement of mechanical properties: Chitosan protonates to form positively charged ammonium ions (-NH3⁺) in an acetic acid dissolution system, while gluconate ions are produced after the dissociation of copper gluconate. The ammonium-gluconate binding can form an ionic crosslinking network, enhancing the mechanical properties of the film.

[0031] 4. Improvement of biocompatibility: After the reaction of sodium citrate and copper gluconate, the concentration of free Cu²⁺ can be reduced, lowering the cytotoxicity of the dressing.

[0032] The preparation method of the liquid wound dressing provided by the present invention has the following beneficial effects compared with the prior art: 1. Good antibacterial performance: Chitosan (natural antibacterial) is combined with copper gluconate (broad-spectrum bacteriostasis) to enhance the antibacterial effect. Meanwhile, multi-target actions (membrane damage, ROS oxidation, enzyme inhibition) reduce the risk of drug resistance caused by a single antibacterial mechanism.

[0033] 2. Fast film formation: The film-forming time of the liquid band-aid prepared by this formula can be shortened to 2 - 4 minutes, which can provide timely protection for the wound and adapt to irregular wound surfaces.

[0034] 3. Guarantee of biological safety: (1) Low irritation: Without an ethanol solvent system, it has little irritation to the skin. (2) Good biocompatibility: After the action of sodium citrate and copper gluconate, the concentration of free Cu²⁺ can be reduced, reducing the cytotoxicity of the dressing.

[0035] 4. High comfort: The cooling sensation brought by L-menthol can relieve wound pain, glycerol keeps the wound moist, and at the same time, the formed film has good flexibility and will not affect the activities of joints and other parts, improving the comfort of users.

[0036] 5. Good stability: After the citrate ion (C6H5O7 3- ) chelates Cu²⁺, it neutralizes its positive charge to ensure the homogeneity and stability of the system. By forming a buffer system with sodium citrate and acetic acid, the pH is precisely regulated, which not only meets the requirements of chitosan dissolution and film formation but also takes into account antibacterial activity and skin safety. The stability of the product is ensured, enabling the components to be evenly mixed, and it is not easy to appear phenomena such as stratification and precipitation during storage and use.

[0037] Specifically, preferably by weight, in step S1, the addition amount of sodium chloride is 0.5 - 1.5 parts, more preferably 0.8 - 1.2 parts; preferably the addition amount of sodium citrate is 0.2 - 1.5 parts, more preferably 0.3 - 1.0 parts; in step S2, the addition amount of copper gluconate is 0.01 - 0.5 parts, more preferably 0.01 - 0.05 parts; in step S3, the addition amount of L-menthol is 0.1 - 2 parts, more preferably 0.5 - 1.5 parts; the addition amount of glycerol is 3 - 15 parts, more preferably 5 - 10 parts; the addition amount of Tween 20 is 0.4 - 3 parts, more preferably 0.5 - 2 parts; in step S5, the addition amount of acetic acid is 0.5 - 3 parts, more preferably 0.5 - 1.5 parts; the addition amount of chitosan is 1 - 3 parts, more preferably 1 - 2 parts.

[0038] Another object of the present invention is to provide a liquid wound dressing prepared by the preparation method of the liquid wound dressing as described above.

[0039] The liquid band-aid provided by the present invention can quickly form a protective film on the wound surface, effectively inhibit the growth of bacteria, promote wound healing, and at the same time has good flexibility and comfort, with little irritation, solving the problems of weak antibacterial performance, strong irritation, slow film formation, etc. existing in the existing band-aids.

[0040] In order to make the above objects, features and advantages of the present invention more obvious and understandable, the following detailed description of the specific embodiments of the present invention is given.

[0041] Example 1 This example provides a preparation method of a liquid band-aid, including the following steps: S1: By weight, add 1 part of sodium chloride and 0.5 part of sodium citrate to 35 parts of pure water, and perform ultrasonic operation until completely dissolved to obtain mixture A; S2: Slowly add 0.03 part of copper gluconate to mixture A, and perform ultrasonic operation to fully disperse copper gluconate in the solution to form mixture B; S3: Mix 1.5 parts of Tween 20 and 8 parts of glycerol evenly, add 1 part of L-menthol, and stir well to form mixture C; S4: Slowly add mixture C to mixture B, and perform ultrasonic operation to fully mix each component to form mixture D; S5: Add 1 part of acetic acid to 50 parts of pure water, mix well and then add 1.5 parts of chitosan, and dissolve it by ultrasonic operation to obtain a chitosan-acetic acid solution; S6: Slowly add the chitosan-acetic acid solution to mixture D, and perform ultrasonic operation to ensure that chitosan is completely dissolved and evenly dispersed to form mixture E; S7: Adjust the pH value of mixture E to 5.5 by adding sodium citrate (appropriate amount of pure water can also be added as needed), filter through a filter to remove possible impurities; fill the filtered solution into a suitable package, label it, and perform irradiation sterilization to obtain the liquid band-aid.

[0042] Example 2 This example provides a preparation method of a liquid band-aid, including the following steps: S1: By weight, add 0.8 part of sodium chloride and 0.3 part of sodium citrate to 41 parts of pure water, and perform ultrasonic operation until completely dissolved to obtain mixture A; S2: Slowly add 0.01 part of copper gluconate to mixture A, and perform ultrasonic operation to fully disperse copper gluconate in the solution to form mixture B; S3: Mix 0.5 part of Tween 20 and 5 parts of glycerol evenly, add 0.5 part of L-menthol, and stir well to form mixture C; S4: Slowly add mixture C to mixture B, and through ultrasonic operation, fully mix each component to form mixture D; S5: Add 0.5 part of acetic acid to 50 parts of pure water, mix well and then add 1 part of chitosan, and dissolve it through ultrasonic operation to obtain a chitosan - acetic acid solution; S6: Slowly add the chitosan - acetic acid solution to mixture D, and through ultrasonic operation, ensure that the chitosan is completely dissolved and evenly dispersed to form mixture E; S7: Adjust the pH value of mixture E to 5.0 by adding an acetic acid solution, filter it through a filter to remove possible impurities; fill the filtered solution into a suitable package, label it, and perform irradiation sterilization to obtain a liquid band - aid.

[0043] Example 3 This example provides a method for preparing a liquid band - aid, which includes the following steps: S1: By weight, add 1.2 parts of sodium chloride and 1 part of sodium citrate to 30 parts of pure water, and through ultrasonic operation until completely dissolved to obtain mixture A; S2: Slowly add 0.05 part of copper gluconate to mixture A, and through ultrasonic operation, fully disperse the copper gluconate in the solution to form mixture B; S3: Mix 2 parts of Tween 20 and 10 parts of glycerol evenly, add 1.5 parts of L - menthol, and stir well to form mixture C; S4: Slowly add mixture C to mixture B, and through ultrasonic operation, fully mix each component to form mixture D; S5: Add 1.5 parts of acetic acid to 50 parts of pure water, mix well and then add 2 parts of chitosan, and dissolve it through ultrasonic operation to obtain a chitosan - acetic acid solution; S6: Slowly add the chitosan - acetic acid solution to mixture D, and through ultrasonic operation, ensure that the chitosan is completely dissolved and evenly dispersed to form mixture E; S7: Adjust the pH value of mixture E to 5.8 by adding sodium citrate (appropriately adding pure water as needed), filter it through a filter to remove possible impurities; fill the filtered solution into a suitable package, label it, and perform irradiation sterilization to obtain a liquid band - aid.

[0044] Comparative Example 1 This comparative example provides a method for preparing a liquid band - aid, which includes the following steps: S1: By weight, add 1 part of sodium chloride and 0.5 part of sodium citrate to 35 parts of pure water, and through ultrasonic operation until completely dissolved to obtain mixture A; S2: Slowly add 0.03 parts of copper gluconate to mixture A. Through ultrasonic operation, make the copper gluconate fully dispersed in the solution to form mixture B; S3: Mix 1.5 parts of Tween 20 and 8 parts of glycerol evenly, add 1 part of L-menthol, and stir well to form mixture C; S4: Slowly add mixture C to mixture B. Through ultrasonic operation, make each component fully mixed to form mixture D; S5: Slowly add 1.5 parts of chitosan to mixture D. Through ultrasonic operation, ensure that the chitosan is evenly dispersed to form mixture E; S6: It was found during the operation that because acetic acid was not added first to pre-dissolve the chitosan, most of the chitosan could not be dissolved. And the pH value of the solution at this time was 6.3, higher than the target pH value of 5.5. Adjust the pH to 5.5 by adding acetic acid solution, and there was still some undissolved chitosan. Filter through a filter to remove possible impurities and undissolved chitosan; Fill the filtered solution into a suitable package, label it, and perform irradiation sterilization to obtain a liquid wound dressing.

[0045] Comparative Example 2 This comparative example provides a method for preparing a liquid wound dressing, including the following steps: S1: According to weight parts, add 1 part of sodium chloride and 0.5 part of sodium citrate to 35 parts of pure water. Through ultrasonic operation until completely dissolved, obtain mixture A; S2: Mix 1.5 parts of Tween 20 and 8 parts of glycerol evenly, add 1 part of L-menthol, and stir well to form mixture B; S3: Slowly add mixture B to mixture A. Through ultrasonic operation, make each component fully mixed to form mixture C; S4: Add 1 part of acetic acid to 50 parts of pure water, mix well and then add 1.5 parts of chitosan. Dissolve it through ultrasonic operation to obtain a chitosan-acetic acid solution; S5: Slowly add the chitosan-acetic acid solution to mixture C. Through ultrasonic operation, ensure that the chitosan is completely dissolved and evenly dispersed to form mixture D; S6: Adjust the pH value of mixture D to 5.5 by adding sodium citrate (pure water can also be added as needed). Filter through a filter to remove possible impurities; Fill the filtered solution into a suitable package, label it, and perform irradiation sterilization to obtain a liquid wound dressing.

[0046] Comparative Example 3 This comparative example provides a method for preparing a liquid wound dressing, including the following steps: S1: By weight, add 1.5 parts of sodium chloride to 35 parts of pure water and perform ultrasonic operation until completely dissolved to obtain mixture A; S2: Slowly add 0.03 part of copper gluconate to mixture A and perform ultrasonic operation to fully disperse copper gluconate in the solution to form mixture B; S3: Mix 1.5 parts of Tween 20 and 8 parts of glycerol evenly, add 1 part of L-menthol, and stir well to form mixture C; S4: Slowly add mixture C to mixture B and perform ultrasonic operation to fully mix all components to form mixture D; S5: Add 1 part of acetic acid to 50 parts of pure water, mix well and then add 1.5 parts of chitosan, and dissolve it by ultrasonic operation to obtain chitosan-acetic acid solution; S6: Slowly add the chitosan-acetic acid solution to mixture D and perform ultrasonic operation to ensure that chitosan is completely dissolved and evenly dispersed to form mixture E; S7: It was found during the operation that due to the failure to add sodium citrate first, partial agglomeration occurred in mixture E. Adjust the pH value of mixture E to 5.5 by adding sodium citrate (appropriate amount of pure water can also be added as needed), and the agglomeration was not completely dissolved. Filter through a filter to remove possible impurities and undissolved substances; fill the filtered solution into a suitable package, label it, and perform irradiation sterilization to obtain a liquid band-aid.

[0047] Comparative Example 4: This example provides a method for preparing a liquid band-aid, including the following steps: S1: By weight, add 1 part of sodium chloride and 0.5 part of sodium citrate to 35 parts of pure water and perform ultrasonic operation until completely dissolved to obtain mixture A; S2: Slowly add 0.03 part of copper gluconate to mixture A and perform ultrasonic operation to fully disperse copper gluconate in the solution to form mixture B; S3: Mix 1 part of L-menthol and 8 parts of glycerol, and stir well to form mixture C; S4: Slowly add mixture C to mixture B and perform ultrasonic operation to fully mix all components to form mixture D; S5: Add 1 part of acetic acid to 50 parts of pure water, mix well and then add 1.5 parts of chitosan, and dissolve it by ultrasonic operation to obtain chitosan-acetic acid solution; S6: Slowly add the chitosan-acetic acid solution to mixture D and perform ultrasonic operation to ensure that chitosan is completely dissolved and evenly dispersed to form mixture E; S7: Adjust the pH value of mixture E to 5.5 by adding sodium citrate, and make up the remaining amount of water. Filter through a filter to remove any possible impurities; fill the filtered solution into a suitable package, label it, and perform irradiation sterilization to obtain a liquid wound dressing.

[0048] Test the performance of the liquid wound dressings prepared in the above examples and comparative examples. The test methods are as follows: 1. Antibacterial performance test: Test the antibacterial performance of the liquid band-aids in the above examples and comparative examples. The test standard is carried out in accordance with GB / T 2591-2003, and the antibacterial rate is calculated; 2. Product stability: Accelerated aging verification tests are carried out on the liquid wound dressings in the above examples and comparative examples in accordance with YY / T 0681.1-2018. That is, the sterilized products are placed in an aging oven at a temperature of 40°C ± 2°C and a humidity of 70% ± 5%. According to the accelerated aging factor (AAF) = Q10

（TAA-TRT） / 10

[0049] 3. Film-forming speed: Take out 5 ml of the liquid wound dressings in the above examples and comparative examples, drop them onto a mold, and record the time from dropping to complete film formation. Each sample is tested independently 5 times.

[0050] The test results are shown in Table 1: Table 1 Antibacterial performance (bacterial reduction rate) Stability Average film-forming time Example 1 99.98% The sample did not change during the entire aging verification cycle. 146s Example 2 99.15% The sample did not change during the entire aging verification cycle. 201s Example 3 ＞99.99% At the last accelerated aging verification observation point (290 days), the color of the sample became darker. 123s Comparative Example 1 90.94% At the third accelerated aging verification observation point (64 days), the sample showed delamination and deterioration, and precipitates appeared Unable to form a complete and uniform thin film Comparative Example 2 75.14% The sample did not change during the entire aging verification cycle. 150s Comparative Example 3 89.25% At the second accelerated aging verification observation point (32 days), the sample showed delamination and deterioration, and precipitates appeared 157s Comparative Example 4 99.96% At the sixth accelerated aging verification observation point (258 days), the sample showed delamination and deterioration, and precipitates appeared. 294s It can be seen from the above table data that the liquid wound dressings prepared in each example of the present invention all have excellent antibacterial properties, rapid film-forming properties, and stability.

[0051] The difference between Comparative Example 1 and Example 1 is that chitosan was directly added without adding pre-dissolved chitosan with acetic acid. Due to the reduced solubility of chitosan, the undissolved chitosan was filtered out during the filtration process, resulting in the inability to form a film for the liquid wound dressing and the instability of the system, and the solution deteriorated in the short term.

[0052] The difference between Comparative Example 2 and Example 1 is that copper gluconate was not added. Due to the lack of the synergistic antibacterial effect of copper gluconate, the antibacterial performance of the liquid wound dressing was reduced.

[0053] The difference between Comparative Example 3 and Example 1 is that sodium citrate was not added. Since chitosan is positively charged (-NH 3⁺ ) in an acidic solution and directly contacts Cu 2+It is easy to generate static adsorption and agglomeration. During the filtration process, the agglomerates are filtered out, resulting in a reduction in the antibacterial performance of the liquid band-aid and an unstable system, with precipitates appearing in the short term.

[0054] The difference between Comparative Example 4 and Example 1 is that Tween 20 was not added. Since it was unable to reduce the surface tension of water and the stability of the dissolution system of L-menthol decreased, the film formation of the liquid band-aid was slow and the system was unstable.

[0055] Enlightened by the above ideal embodiments based on the present invention, through the above description, relevant staff can completely make various changes and modifications without departing from the technical idea of this invention. The technical scope of this invention is not limited to the content in the specification, and its technical scope must be determined according to the scope of the claims.

Claims

1. A method for preparing a liquid wound dressing, characterized in that: The steps include: S1: adding sodium chloride and sodium citrate into water according to the formula amount, dissolving them to obtain a mixture A; S2: adding copper gluconate to mixture A to form mixture B; S3: Mix Tween 20 and glycerol, add L-menthol, and stir to form a mixture C; S4: adding the mixture C to the mixture B to form a mixture D; S5: adding acetic acid to water, mixing well, adding chitosan, and dissolving to obtain a chitosan-acetic acid solution; S6: adding the chitosan-acetic acid solution to the mixture D to dissolve and form a mixture E; S7: adjusting the pH value of the mixture E to 4.5-6.5, filtering, filling, and sterilizing to obtain a liquid wound dressing.

2. The method for preparing the liquid wound dressing according to claim 1, characterized in that: In terms of parts by weight, the amount of sodium chloride added in step S1 is 0.5-1.5 parts.

3. The method for preparing the liquid wound dressing according to claim 1, characterized in that: In terms of parts by weight, the amount of sodium citrate added in step S1 is 0.2-1.5 parts.

4. The method for preparing the liquid wound dressing according to claim 1, characterized in that: In terms of parts by weight, the amount of copper gluconate added in step S2 is 0.01-0.5 parts.

5. The method for preparing the liquid wound dressing according to claim 1, characterized in that: In terms of parts by weight, the amount of L-menthol added in step S3 is 0.1-2 parts.

6. The method for preparing the liquid wound dressing according to claim 1, characterized in that: In terms of parts by weight, the amount of glycerol added in step S3 is 3-15 parts.

7. The method for preparing the liquid wound dressing according to claim 1, characterized in that: In terms of weight parts, the amount of Tween 20 added in step S3 is 0.4-3 parts.

8. The method for preparing the liquid wound dressing according to claim 1, characterized in that: In terms of parts by weight, the amount of acetic acid added in step S5 is 0.5-3 parts.

9. The method for preparing the liquid wound dressing according to claim 1, characterized in that: In terms of weight, the amount of chitosan added in step S5 is 1-3 parts.

10. A liquid wound dressing, characterized in that: The liquid wound dressing is prepared by the preparation method of any one of claims 1 to 8.