Process for transferring and sterilizing inner bags of multilayer sterilization-free plastic bottles in and out of sterilization box

Abstract

The invention relates to a multilayer sterilization-free plastic bottle inner bag entering and exiting sterilization box transferring and sterilizing process which comprises the following steps: S1, box entering preparation: receiving a plastic bottle bag through a box entering lifting moving platform A, and pushing the plastic bottle bag into a multi-layer target position of a box entering temporary storage rack B after servo positioning; s2, box feeding: opening a forward door of the sterilization box D, turning over a box feeding turning plate B2 to form a transition channel, and pushing the plastic bottle bags into a multi-layer fixing frame D4 by a synchronous box feeding push rod C; s3, sterilization and residue removal: sequentially performing preheating dehumidification, hydrogen peroxide aerosol sterilization and residue removal until the residue concentration is less than or equal to 1ppm; s4, box discharging, specifically, a rear sliding door is opened, a box discharging turning plate E2 is turned over to form a transition channel, and the plastic bottle bags are subjected to vacuum adsorption to a box discharging temporary storage frame E; and S5, box discharging and transferring are conducted, specifically, a box discharging suction rod F adsorbs the plastic bottle bags to a box discharging lifting moving platform G and transfers the plastic bottle bags to a follow-up station. Full-process automation is achieved, the risk of artificial pollution is eradicated, production continuity and cleanliness stability are improved, and the device is particularly suitable for front-end production of a veterinary drug vaccine plastic bottle filling and sealing production line.

Description

Technical Field

[0001] This invention relates to the field of sterilization equipment technology, and in particular to a process for transferring and sterilizing inner bags of multi-layer sterile plastic bottles into and out of sterilization boxes. It utilizes a device suitable for transferring and sterilizing inner bags of large sterile plastic bottle packaging in pharmaceutical production, especially suitable for multi-layer stacking, entering and exiting sterilization boxes, and transferring inner bags of large vaccine plastic bottle packaging after removing the outer packaging in veterinary drug production to subsequent workstations. Background Technology

[0002] Previously, when large packaging bottles of sterile plastic bottles entered the cleanroom during pharmaceutical production, the outer surface of the plastic bag required an external cleaning process. The outer bag was then manually removed, and the sterile plastic bottle with the inner bag was manually transported to the sterilization cabinet or room. After the inner bag surface was sterilized, it was taken out from another area. The sterile plastic bottle with the inner bag was then manually transported to the RABS (Remote Absorption System) of the filling machine in a Class B area for self-cleaning. After that, the inner bag was removed again by the manual person wearing gloves and transferred to the buffer turntable of the filling machine.

[0003] The disadvantages of this traditional process are: (1) multiple manual handling and transfer, which increases the labor intensity of operators and the production cost; (2) the number of operators in the two clean areas is large and the range of operations is large, which will inevitably affect the dynamic cleanliness index of the clean area (especially Grade B), making it difficult to meet the requirements of drug production validation; (3) due to the manual handling and transfer to the RABS process of the filling machine, the Grade A unidirectional flow cannot effectively protect the exposed surfaces of the inner bag of the plastic bottle packaging, and surface contaminants will be brought in, posing a risk of cross-contamination. Summary of the Invention

[0004] To address the shortcomings of existing technologies, the purpose of this invention is to provide a process for transferring and sterilizing the inner bag of a multi-layer sterile plastic bottle into and out of the sterilization chamber. This process achieves full automation, eliminates the risk of human contamination, and improves production continuity and cleanliness stability. It is particularly suitable for the front-end production of veterinary drug and vaccine plastic bottle filling and sealing production lines.

[0005] The above-mentioned objective of this invention is achieved through the following technical solutions:

[0006] A process for transferring and sterilizing inner bags of multi-layer sterile plastic bottles into and out of a sterilization chamber includes the following steps:

[0007] S1. Box entry preparation: The plastic bottle package is received by the box entry lifting and moving platform A, and after being positioned by the servo, it is pushed into the multi-layer target position of the box entry temporary storage rack B.

[0008] S2. Entering the chamber: Open the front door of the sterilization chamber D, flip the inlet flap B2 to form a transition channel, and simultaneously push the inlet push rod C to push the plastic bottle pack into the multi-layer fixing rack D4;

[0009] S3. Sterilization and residue removal: Perform preheating and dehumidification, hydrogen peroxide aerosol sterilization, and residue removal sequentially until the residual concentration is ≤1ppm;

[0010] S4. Unpacking: Open the rear sliding door, flip the unpacking flap E2 to form a transition channel, and vacuum suction the plastic bottle package to the unpacking temporary storage rack E.

[0011] S5. Unpacking and Transfer: The unpacking suction rod F adsorbs the plastic bottle bag and transfers it to the unpacking lifting and moving platform G, and then to the subsequent workstation.

[0012] As a further technical solution of the present invention: S1 includes the following steps: the box-in lifting and moving platform A drives the box-in moving screw A2 and the box-in lifting screw A3 through a servo motor, with a positioning accuracy of ±0.5mm, and the push rod cylinder A8 pushes the plastic bottle packs into different layers of the box-in temporary storage rack B in stages.

[0013] As a further technical solution of the present invention: In S2, the multiple sets of box-in push rod cylinders C4 of the box-in push rod C are synchronously driven by the box-in drive cylinder C3, and the synchronization error is ≤1ms.

[0014] As a further technical solution of the present invention: S3 includes the following steps: preheating and dehumidification: the inner cavity D2 is heated to 40-45℃ and the humidity is reduced to below 10%RH; sterilization: the concentration of hydrogen peroxide is atomized at 6-10mg / L for 25-35min; residue removal: the airflow is decomposed into H2O and O2 by the catalyst.

[0015] As a further technical solution of the present invention: after sterilization, let stand for 10 minutes, and then start the residue removal program.

[0016] As a further technical solution of the present invention: in S4, the suction force of the first vacuum suction head F5 is 0.06-0.08MPa, and the synchronous movement speed of the suction rod cylinder F4 is 0.2-0.5m / s.

[0017] As a further technical solution of the present invention: S5 includes the following steps: the box-out lifting and moving platform G adsorbs the plastic bottle package through the second suction head G6; the box-out push rod cylinder G9 pushes the moving frame G8 in three stages with adjustable speed.

[0018] As a further technical solution of the present invention: after the inlet flap B2 and the outlet flap E2 are rotated 90°, the height difference between them and the multi-layer fixing frame D4 is ≤2mm. The rotation of the inlet flap B2 is achieved by the inlet cylinder B4 driving the inlet connecting rod B3, and the rotation of the outlet flap E2 is achieved by the outlet cylinder E4 driving the outlet connecting rod E3. The response time of both is ≤0.5s.

[0019] As a further technical solution of the present invention: the entire process is controlled by PLC, and the time interval between switching steps is ≤3s.

[0020] In summary, the present invention has at least one of the following beneficial technical effects:

[0021] 1. This invention discloses a process for transferring and sterilizing inner bags of multi-layer sterile plastic bottles into and out of a sterilization chamber, comprising: servo-positioned pushing of the plastic bottle bag during the pre-induction stage; synchronous pushing into the sterilization chamber during the induction stage; sequential execution of preheating and dehumidification, hydrogen peroxide sterilization, and catalytic residue removal to ≤1ppm during the sterilization and residue removal stage; vacuum adsorption transfer during the out-of-chamber stage; and corresponding pushing to the subsequent workstation during the out-of-chamber transfer stage. This process achieves fully automated control, with precise and adjustable sterilization parameters, eliminating the risk of human contamination, and is suitable for the front-end production of veterinary drug and vaccine plastic bottle filling and sealing production lines.

[0022] 2. This invention employs a multi-layer sterile plastic bottle inner bag transfer and sterilization device. The device includes, in sequence, an inlet lifting and moving platform, an inlet temporary storage rack, an inlet push rod, a sterilization box, an outlet temporary storage rack, an outlet suction rod, and an outlet lifting and moving platform. The inlet lifting and moving platform stacks the plastic bottle packages onto the inlet temporary storage rack. After the flip plate is over, the inlet push rod pushes the entire package into the sterilization box. After the hydrogen peroxide sterilization system completes sterilization and residue removal, the outlet suction rod transfers the plastic bottle package to the outlet temporary storage rack via a vacuum suction head. Finally, the outlet lifting and moving platform transfers the package to the next process. This device achieves full-process automation, eliminates the risk of human contamination, and improves production continuity and cleanliness stability. It is particularly suitable for the front-end production of veterinary drug and vaccine plastic bottle filling and sealing production lines.

[0023] 3. This invention uses an infeed lifting and moving platform to automatically stack and push multiple layers of packaged plastic bottles (with outer plastic bags removed) into the infeed temporary storage rack. When the infeed temporary storage rack is full of inner bag plastic bottle packages, the front door of the sterilization chamber opens, and the infeed push rod pushes the inner bag plastic bottle packages from the infeed temporary storage rack into the multi-layer fixed rack of the sterilization chamber, and the front door closes. The sterilization chamber then starts the sterilization and residue removal process, and the rear door opens after the sterilization and residue removal process. At this time, the outfeed suction rack sucks out the corresponding inner bag plastic bottle packages and stores them on the outfeed temporary storage rack, and the rear door closes. Subsequently, the outfeed lifting and moving platform automatically sucks out the bottles from the outfeed temporary storage rack and transfers them to the next workstation.

[0024] 4. This device is a replacement for manual multiple transfers of sterile plastic bottle bulk packaging into and out of the sterilization box and sterilization box. It is especially suitable for multi-layer stacking of inner bags after removing the outer packaging in the large packaging of vaccine plastic bottles in veterinary drug production, entering the sterilization box, exiting the box in multiple layers, and transferring to the subsequent work station. Its features are: (1) Automatic operation, no need for multiple manual handling, reducing the labor intensity of operators; (2) Reduce the number of people in the B-level area, making the dynamic cleanliness index of B-level stable, while the sterilization parameters are controllable and uniform, meeting the requirements of drug production validation; (3) Through the temporary storage rack, the original non-continuous production mode is transformed into relatively continuous production. Attached Figure Description

[0025] Figure 1 This is a top view of the device of the present invention.

[0026] Figure 2 This is a side view of the device of the present invention.

[0027] Figure 3 This is a front view of the box-loading lifting and moving platform of the device of the present invention.

[0028] Figure 4 This is a top view of the box-loading lifting and moving platform of the device of the present invention.

[0029] Figure 5 This is a side view of the box-loading lifting and moving platform of the device of the present invention.

[0030] Figure 6 This is a front view of the temporary storage rack for the device of the present invention.

[0031] Figure 7 This is a top view of the temporary storage rack for the device of the present invention.

[0032] Figure 8 This is a side view and a partially enlarged schematic diagram of the temporary storage rack for the container of the present invention.

[0033] Figure 9 This is a front view of the push rod for feeding the box in the device of the present invention.

[0034] Figure 10 This is a top view of the box-feeding push rod of the device of the present invention.

[0035] Figure 11 This is a front view of the sterilization chamber of the device of the present invention.

[0036] Figure 12 This is a top view of the sterilization chamber of the device of the present invention.

[0037] Figure 13 This is a side view of the sterilization chamber of the device of the present invention.

[0038] Figure 14 This is a front view of the unpacking temporary storage rack of the device of the present invention.

[0039] Figure 15 This is a top view of the unpacking temporary storage rack of the device of the present invention.

[0040] Figure 16 This is a side view of the unpacking temporary storage rack of the device of the present invention.

[0041] Figure 17 This is a front view of the suction rod for discharging from the box in the device of the present invention.

[0042] Figure 18 This is a side view of the suction rod for discharging from the box in the device of the present invention.

[0043] Figure 19 This is a front view of the box-ejection lifting and moving platform of the device of the present invention.

[0044] Figure 20 This is a side view of the unloading lifting and moving platform of the device of the present invention.

[0045] Figure 21 This is a top view of the box-ejection lifting and moving platform of the device of the present invention.

[0046] Reference numerals: A, Box-infeed lifting and moving platform; A1, Box-infeed frame; A2, Box-infeed moving screw; A3, Box-infeed lifting screw; A4, Box-infeed platform; A5, Box-infeed docking plate; A6, Push rod; A7, Ejection cylinder; A8, Push rod cylinder; A9, Box-infeed base;

[0047] B. Inlet storage rack; B1. First storage rack; B2. Inlet flap; B3. Inlet connecting rod; B4. Inlet cylinder;

[0048] C. Box inlet push rod; C1. First support; C2. Box inlet push plate; C3. Box inlet drive cylinder; C4. Box inlet push rod cylinder;

[0049] D. Sterilization chamber; D1. Chamber body; D2. Inner cavity; D3. Hydrogen peroxide sterilization system; D3.1. Hydrogen peroxide sterilizer; D3.2. Inlet / outlet piping; D4. Mounting frame; D5. Panel; D6. Front and rear sliding doors; D6.1. Front and rear sliding door cylinder; D6.2. Front and rear sliding door body; D6.3. Front and rear sliding door sealing ring; D6.4. Front and rear sliding door track;

[0050] E, Outbound Temporary Storage Rack; E1, Second Temporary Storage Rack; E2, Outbound Flip Plate; E3, Outbound Linkage Rod; E4, Outbound Cylinder;

[0051] F, ejector suction rod; F1, second support; F2, ejector push plate; F3, ejector drive cylinder; F4, suction rod cylinder; F5, first suction head;

[0052] G. Box ejection lifting and moving platform; G1. Frame; G2. Box ejection moving screw; G3. Box ejection lifting screw; G4. Box ejection platform; G5. Lifting cylinder; G6. Second suction head; G7. Slide rail; G8. Moving frame; G9. Box ejection push rod cylinder; G10. Box ejection docking plate; G11. Box ejection base. Detailed Implementation

[0053] The technical solutions in the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of this application without creative effort are within the scope of protection of this application.

[0054] In the description of this application, it should be noted that the terms "upper," "lower," "inner," "outer," "top / bottom," etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this application. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0055] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installed," "equipped with," "sleeved / connected," "connected," etc., should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be a connection within two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0056] Example 1:

[0057] This invention discloses a process for transferring and sterilizing the inner bag of a multi-layer sterile plastic bottle into and out of a sterilization chamber, comprising the following steps:

[0058] S1. Box entry preparation: The plastic bottle package is received by the box entry lifting and moving platform A, and after being positioned by the servo, it is pushed into the multi-layer target position of the box entry temporary storage rack B.

[0059] S2. Entering the chamber: Open the front door of the sterilization chamber D, flip the inlet flap B2 to form a transition channel, and simultaneously push the inlet push rod C to push the plastic bottle pack into the multi-layer fixing rack D4;

[0060] S3. Sterilization and residue removal: Perform preheating and dehumidification, hydrogen peroxide aerosol sterilization, and residue removal sequentially until the residual concentration is ≤1ppm;

[0061] S4. Unpacking: Open the rear sliding door, flip the unpacking flap E2 to form a transition channel, and vacuum suction the plastic bottle package to the unpacking temporary storage rack E.

[0062] S5. Unpacking and Transfer: The unpacking suction rod F adsorbs the plastic bottle bag and transfers it to the unpacking lifting and moving platform G, and then to the subsequent workstation.

[0063] Furthermore, S1 includes the following steps: the inlet lifting and moving platform A drives the inlet moving screw A2 and the inlet lifting screw A3 through a servo motor, with a positioning accuracy of ±0.5mm; the push rod cylinder A8 pushes the plastic bottle packs into different layers of the inlet temporary storage rack B in stages.

[0064] In S2, the multiple sets of box-in push rod cylinders C4 of the box-in push rod C are synchronously driven by the box-in drive cylinder C3, with a synchronization error of ≤1ms.

[0065] S3 includes the following steps: Preheating and dehumidification: The inner cavity D2 is heated to 40-45℃, and the humidity is reduced to below 10%RH; Sterilization: Hydrogen peroxide is atomized at a concentration of 6-10mg / L for 25-35 minutes; Residue removal: The airflow is decomposed into H2O and O2 by the catalyst. After sterilization, the mixture is allowed to stand for 10 minutes before starting the residue removal program.

[0066] In S4, the suction force of the first vacuum suction head F5 is 0.06-0.08MPa, and the synchronous movement speed of the suction rod cylinder F4 is 0.2-0.5m / s.

[0067] S5 includes the following steps: the box-out lifting and moving platform G uses the second suction head G6 to absorb the plastic bottle package; the box-out push rod cylinder G9 pushes the moving frame G8 in three stages of speed adjustment.

[0068] Furthermore, after the inlet flap B2 and outlet flap E2 rotate 90°, the height difference between them and the multi-layer fixing frame D4 is ≤2mm. The rotation of the inlet flap B2 is achieved by the inlet cylinder B4 driving the inlet connecting rod B3, and the rotation of the outlet flap E2 is achieved by the outlet cylinder E4 driving the outlet connecting rod E3, with a response time of ≤0.5s for both. The entire process is controlled by PLC, and the time interval between each step is ≤3s.

[0069] Reference Figures 1-21 This invention relates to a multi-layer sterile plastic bottle inner bag transfer and sterilization device, comprising, in sequence, an inlet lifting and moving platform A, an inlet temporary storage rack B, an inlet push rod C, a sterilization box D, an outlet temporary storage rack E, an outlet suction rod F, and an outlet lifting and moving platform G; the sterilization box D has multiple layers of fixed racks D4 and a hydrogen peroxide sterilization system D3 inside; both the inlet temporary storage rack B and the outlet temporary storage rack E are multi-layer frame structures, and each layer has an inlet flap B2 and an outlet flap E2 that can be rotated 90° at the front end; the sterilization box D has inflatable and sealed front and rear sliding doors D6 at the front and rear ends respectively.

[0070] The inlet lifting and moving platform A includes an inlet frame A1, an inlet moving screw A2, an inlet lifting screw A3, an inlet platform A4, an inlet docking plate A5, a push rod A6, an ejection cylinder A7, a push rod cylinder A8, and an inlet base A9.

[0071] The infeed frame A1 is located above the infeed base A9. The infeed moving screw A2 is used to drive the infeed frame A1 to move left and right. The infeed lifting screw A3 is used to drive the infeed platform A4 to lift. The infeed docking plate A5 is installed at the front end of the infeed platform A4. The ejection cylinder A7 is used to drive the push rod A6 to enter the infeed platform A4. The push rod A6 is fixed on the output shaft of the push rod cylinder A8. The push rod cylinder A8 drives the push rod A6 to push the plastic-wrapped bottles.

[0072] Furthermore, the infeed frame A1 can be raised and lowered and moved left and right. Specifically: the infeed frame A1 is an L-shaped frame with two longitudinal slots, which allow the infeed platform A4 to be raised and lowered; the infeed lifting screw A3 is a servo-electric screw, which allows the infeed platform A4 to be raised and lowered; the infeed moving screw A2 is a servo-electric screw, which allows the infeed frame A1 to move left and right; the infeed platform A4 is flat with connecting rods underneath; the infeed docking plate A5 is plate-shaped, allowing the packaged plastic bottles to be pushed into the subsequent processing section for transition; the push rod A6 is strip-shaped, pushing the packaged plastic bottles; the ejector cylinder A7 allows the push rod A6 to enter the infeed platform A4; and the push rod cylinder A8 drives the push rod A6 to push the packaged plastic bottles. In the above: the infeed frame A1 is located above the infeed base A9; the infeed lifting screw A3 is fixed longitudinally (on the side with the long slot) of the infeed frame A1, and the threaded sleeve of the infeed lifting screw A3 is connected to the infeed platform A4 to raise and lower it; the infeed moving screw A2 is fixed on the base A9, and its threaded sleeve is fixed to the bottom of the infeed frame A1 to move the infeed frame A1; the infeed platform A4 is assembled on the infeed lifting screw A3 in the long slot of the infeed frame A1 using its lower connecting rod; the infeed docking plate A5 is plate-shaped and fixed to the front end of the inlet platform A4; push rod A6 is fixed on the shaft of push rod cylinder A8 and is moved to above the inlet platform A4 by the action of ejector cylinder A7, and returns to below the inlet platform A4 when not pushing; ejector cylinder A7 is located below push rod cylinder A8 and at the lower left of the inlet platform A4; ejector cylinder A7 is fixed at the lower left of the inlet platform A4, and its other end is connected to push rod cylinder A8; push rod A6 is fixed above ejector cylinder A7, and its shaft is connected to push rod A6.

[0073] The inlet storage rack B includes a first storage rack B1, an inlet flap B2, an inlet connecting rod B3, and an inlet cylinder B4. The inlet flap B2 is connected to the inlet cylinder B4 through the multi-hole inlet connecting rod B3, so as to realize the switching between the vertical baffle and the horizontal transition plate of the inlet flap B2.

[0074] Furthermore, the first temporary storage rack B1 is a multi-layer frame welded from stainless steel round bars; the inlet flap B2 is a flat plate with support pins at both ends, which can rotate 90° and has a dual function: when rotated, it acts as a baffle for the plastic-coated bottles, and when flattened, it acts as a transition plate for pushing the plastic-coated bottles into the subsequent processing section; the inlet connecting rod B3 is a rod with multiple holes in the middle. In the above, the first temporary storage rack B1 is fixed to a load-bearing foundation; the inlet flap B2 is located in the front end holes of each layer of the first temporary storage rack B1; the inlet connecting rod B3 is fitted onto each layer of the inlet flap B2, and the bottom of the inlet connecting rod B3 is connected to the inlet cylinder B4. When the inlet cylinder B4 is activated, it drives the inlet flap B2 to rotate 90°.

[0075] The inlet push rod C includes a first support C1, an inlet push plate C2, an inlet driving cylinder C3, and an inlet push rod cylinder C4. The inlet driving cylinder C3 is fixed on the first support C1 and located between the inlet push plate C2 and the inlet push rod cylinder C4. The output shaft of the inlet driving cylinder C3 is fixedly connected to the inlet push plate C2. The inlet push rod cylinder C4 is connected to the inlet push plate C2. When the inlet driving cylinder C3 moves, it will drive the inlet push plate C2 to move back and forth, and at the same time drive multiple sets of inlet push rod cylinders C4 to move back and forth.

[0076] Furthermore, the first support C1 is an L-shaped support base with a bearing on it; the inlet push plate C2 is flat, and its movement can drive the inlet push rod cylinder C4 to move back and forth; the inlet driving cylinder C3 drives the inlet push plate C2 to move; multiple sets of inlet push rod cylinders C4 are composed of pairs of cylinders corresponding to the number of layers / columns in the inlet temporary storage rack B, and they can move back and forth. In the above, the inlet push rod cylinder C4 is fitted inside the bearing on the vertical surface of the first support C1, with its tail end fixed to the surface of the inlet push plate C2, and its head positioned at the front end of the first support C1; the inlet driving cylinder C3 is located between the first support C1 and the inlet push plate C2, and when the inlet driving cylinder C3 moves, it drives the inlet push plate C2 to move back and forth, simultaneously driving the multiple sets of inlet push rod cylinders C4 to move back and forth.

[0077] The sterilization chamber D includes a chamber body D1, an inner cavity D2, a hydrogen peroxide sterilization system D3, a fixing frame D4, a panel D5, and front and rear sliding doors D6. The inner cavity D2 is located inside the chamber body D1. The multi-layer fixing frame D4 is located in the inner cavity D2. Two hydrogen peroxide sterilization systems D3 are configured and symmetrically located on the left and right sides of the inner cavity D2. The panel D5 is fixed to the open part of the chamber body D1. The front and rear sliding doors D6 are located on the left and right sides of the chamber body D1, respectively.

[0078] Furthermore, the housing D1 is welded from a frame, supporting and connecting various components; the inner cavity D2 is box-shaped with front and rear openings, and sliding door tracks are installed on the front and rear end faces; the hydrogen peroxide sterilization system D3 consists of a hydrogen peroxide sterilizer D3.1 and inlet / outlet pipes D3.2; the multi-layered fixing frame D4 is a multi-layered frame welded from stainless steel round steel; the front and rear sliding doors D6 consists of front and rear sliding door cylinders D6.1, front and rear sliding door bodies D6.2, front and rear sliding door sealing rings D6.3, and front and rear sliding door tracks D6.4. The front and rear sliding door bodies D6.2 are left and right opening types, and the inner end faces of the front and rear sliding door bodies D6.2 have sealing grooves. The front and rear sliding door sealing rings D6.3 are made of inflatable silicone rubber tubing rings.

[0079] In the above configuration, the inner cavity D2 is fixedly fitted within the frame of the chamber D1; two hydrogen peroxide sterilizers D3.1 are placed approximately inside the chamber D1, with one end of the inlet / outlet pipe D3.2 connected to the inlet / outlet of the hydrogen peroxide sterilizer D3.1 and the other end connected to the top or bottom interface of the inner cavity D2; a multi-layered mounting bracket D4 is fixed within the inner cavity D2; a panel D5 is fixed to the open portion of the chamber D1; and front and rear sliding door tracks D6.4 are fixed at the front and rear ends of the chamber D1, located at the front and rear openings of the inner cavity D2. The front and rear sliding door bodies D6.2 are inserted into the front and rear sliding door tracks D6.4. Front and rear sliding door sealing rings D6.3 are embedded in the sealing grooves around the inner sides of the front and rear sliding door bodies D6.2. When the door is closed, the sealing rings D6.3 are filled with air to form a seal. The front and rear sliding door cylinders D6.1 are fixed to the chamber D1 above the door, and their movement controls the opening and closing of the door.

[0080] The unloading temporary storage rack E includes a second temporary storage rack E1, an unloading flap E2, an unloading connecting rod E3, and an unloading cylinder E4. The unloading flap E2 is connected to the unloading cylinder E4 through the multi-hole unloading connecting rod E3, so as to realize the switching between the vertical baffle and the horizontal transition plate of the unloading flap E2.

[0081] Furthermore, the second temporary storage rack E1 is a multi-layered frame welded from stainless steel round bars; the unloading flap E2 is a flat plate with support pins at both ends, capable of rotating 90°, serving a dual function: when rotated, it acts as a baffle for the plastic-coated bottles, and when flattened, it serves as a transition plate for pushing the plastic-coated bottles into subsequent processing sections; the unloading connecting rod E3 is a rod with multiple holes in the middle. The second temporary storage rack E1 is fixed to a load-bearing foundation; the unloading flap E2 is located within the front end holes of each layer of the second temporary storage rack E1; the unloading connecting rod E3 is fitted onto each layer of the unloading flap E2, and the bottom of the unloading connecting rod E3 is connected to the unloading cylinder E4, which, when activated, causes the unloading flap E2 to rotate 90°.

[0082] The box-ejection suction rod F includes a second support F1, a box-ejection push plate F2, a box-ejection driving cylinder F3, and a suction rod cylinder F4. The box-ejection driving cylinder F3 is fixed on the second support F1 and located between the box-ejection push plate F2 and the suction rod cylinder F4. The output shaft of the box-ejection driving cylinder F3 is fixedly connected to the box-ejection push plate F2. The suction rod cylinder F4 is connected to the box-ejection push plate F2. When the box-ejection driving cylinder F3 moves, it will drive the box-ejection push plate F2 to move back and forth, and at the same time drive multiple suction rod cylinders F4 to move back and forth. A first suction head F5 is provided on the end face of the output shaft of the suction rod cylinder F4.

[0083] Furthermore, the second support F1 is an L-shaped support base with a bearing on it; the ejector plate F2 is flat, and its movement can drive the suction cylinder F4 to move back and forth; the ejector-driven cylinder F3 drives the ejector plate F2 to move; multiple suction cylinders F4 are composed of the number of air pairs corresponding to the middle layer / row of the temporary storage rack E, and they can move back and forth; the first suction head F5 is a silicone rubber vacuum tube. The aforementioned suction cylinder F4 is fitted inside the bearing on the vertical surface of the second support F1, with its tail end fixed to the surface of the ejector plate F2, and its head positioned at the front end of the second support F1; the ejector-driven cylinder F3 is located between the second support F1 and the ejector plate F2, and when the ejector-driven cylinder F3 moves, it drives the ejector plate F2 to move back and forth, simultaneously driving the multiple suction cylinders F4 to move back and forth; the first suction head F5 is fixed to the front end of the suction cylinder F4.

[0084] The box-out lifting and moving platform G includes a box-out frame G1, a box-out moving screw G2, a box-out lifting screw G3, a box-out platform G4, a lifting cylinder G5, a second suction head G6, a slide rail G7, a moving frame G8, a box-out push rod cylinder G9, a box-out docking plate G10, and a box-out base G11.

[0085] The carton ejector frame G1 is located above the carton ejector base G11. The carton ejector moving screw G2 is used to drive the carton ejector frame G1 to move left and right. The carton ejector lifting screw G3 is used to drive the carton ejector platform G4 to lift. The carton ejector docking plate G10 is installed at the front end of the carton ejector platform G4. The slide rail G7 is set on both sides of the carton ejector platform G4. The moving frame G8 is slidably set on the carton ejector platform G4 through the slide rail G7. The lifting cylinder G5 is installed on the moving frame G8. The second suction head G6 is installed on the output shaft of the lifting cylinder G5. The carton ejector push rod cylinder G9 is used to drive the moving frame G8 to move, so as to realize the transfer of the packaged plastic bottles to the carton ejector frame G1.

[0086] Furthermore, the box ejector frame G1 can be raised and lowered and moved left and right. The box ejector frame G1 is an L-shaped frame with two longitudinal slots, which allow the box ejector platform G4 to be raised and lowered. The box ejector lifting screw G3 is a servo-electric screw, which allows the box ejector platform G4 to be raised and lowered. The box ejector moving screw G2 is a servo-electric screw, which allows the box ejector frame G1 to move left and right. The box ejector platform G4 is flat, with two slide rail slots on the upper surface and connecting rods at the bottom. The lifting cylinder G5 drives the second suction head G6 to be raised and lowered. The second suction head G6 is a silicone rubber vacuum tube. The slide rail G7 is a linear guide rail with an optical axis. The moving frame G8 is a bridge-shaped frame, which drives the second suction head G6 to move back and forth. The box ejector pusher cylinder G9 drives the moving frame G8 to move back and forth, and simultaneously pulls out the packaged plastic bottles under the action of the second suction head G6. The box ejector docking plate G10 is plate-shaped, allowing the packaged plastic bottles to be pushed into the subsequent processing section for transition.

[0087] The aforementioned box-ejecting frame G1 is located above the box-ejecting base G11; the box-ejecting lifting screw G3 is fixed longitudinally (on the side with the long slot) of the box-ejecting frame G1, and the sleeve of the box-ejecting lifting screw G3 is connected to the box-ejecting platform G4, allowing it to rise and fall; the box-ejecting moving screw G2 is fixed on the box-ejecting base G11, and its sleeve is fixed to the bottom of the box-ejecting frame G1, allowing the box-ejecting frame G1 to move; the box-ejecting platform G4 is assembled onto the box-ejecting lifting screw G3 in the long slot of the box-ejecting frame G1 using its lower connecting rod; the box-ejecting lifting cylinder G3 is fixed on the moving frame G8, and one end is connected to the second suction head G6, which sucks up the plastic-coated bottles. The first suction head extends when suctioning and retracts when not suctioning; the second suction head G6 is fixed on the lifting cylinder G5 and is located on one side; the slide rail G7 is embedded in the groove of the box-out platform G4 and is connected to the moving frame G8 through its slider; the moving frame G8 is located on the box-out platform G4 and is connected to the slide rail G7; the box-out push rod cylinder G9 is fixed to the lower left of the box-out platform G4, and the other end is connected to the moving frame G8. It extends when suctioning the plastic-wrapped bottle and retracts when not suctioning; it is moved above the box-out platform G4 by the lifting cylinder G5 and returns below the box-out platform G4 when not pushing; the box-out docking plate G10 is plate-shaped and fixed to the front end of the box-out platform G4.

[0088] In this embodiment, the in-box flap B2 and the out-box flap E2 are flat plates with support pins at both ends. After flipping, they are flush with the multi-layered fixed frame D4 of the sterilization box D, forming a transition channel. The in-box lifting platform A and the out-box lifting platform G are both controlled by servo motors and PLCs to achieve layer / column positioning.

[0089] In this embodiment, a sterilization process for transferring inner bags of multi-layer sterile plastic bottles into and out of a sterilization chamber and for the sterilization chamber device specifically includes the following steps:

[0090] Step 1, Preparation for Boxing:

[0091] (1) The entire package of plastic bottles with the outer bag removed from the previous process is loaded onto the box-in platform A4 in the box-in lifting and moving platform A.

[0092] (2) In the box-in lifting and moving platform A, the box-in platform A4 is adjusted up and down to the corresponding high position of the box-in temporary storage rack B by the box-in lifting screw A3. Then, the box-in platform A4 moves left and right by the box-in moving screw A2. When the box-in platform A4 reaches the corresponding column, the box-in docking plate A5 docks with the corresponding layer / column of the box-in temporary storage rack B. The ejector cylinder A7 ejects the push rod cylinder A8 onto the box-in platform A4. The push rod cylinder A8 moves and pushes the packaged plastic bottle into the corresponding layer and column of the box-in temporary storage rack B. After one package is pushed in, the box-in lifting and moving platform A returns to its original position by the box-in moving screw A2, the box-in lifting screw A3, the box-in moving screw A2, and the box-in lifting screw A3. The package is pushed multiple times until the box-in temporary storage rack B is full.

[0093] (3) During this period, the infeed moving screw A2 and the infeed lifting screw A3 are controlled by servo motor and PLC. Each time a bag is pushed into the infeed temporary storage rack B, the servo motor and PLC control will change the layer or column position parameters of the next bag. After the bag is pushed, each motion unit returns to its original state.

[0094] Step two, placing it in the box:

[0095] (1) After the storage rack B is filled with multiple layers of plastic bottles, the sealing ring of the front door of the sterilizer D is depressurized and opened under the action of the door cylinder (the rear door is closed). The rear door flap B2 of the storage rack B is rotated 90° to a horizontal position under the combined action of the door cylinder B4 and the door connecting rod B3, and is flush with each layer of the panel D5 of the multi-layer fixed rack D4 in the sterilizer D, which serves as a bridge for pushing the bottles across.

[0096] (2) When the inlet push rod C3 drives the inlet push plate C2 forward, it also pushes multiple inlet push rod cylinders C4 forward. The multiple inlet push rod cylinders C4 push in succession, which pushes the whole package of plastic bottles in the inlet temporary storage rack B into the corresponding layer of the multi-layer fixed rack D4 of the sterilization box D. Then, the inlet flip plate B2 at the rear end of the inlet temporary storage rack B flips 90° to restore its original state under the combined action of the inlet cylinder B4 and the inlet connecting rod B3. At the same time, all moving units are restored.

[0097] (3) The front sliding door of sterilizer D closes under the action of the sliding door cylinder, and the sealing ring is inflated to seal it;

[0098] The third step is sterilization and residue removal:

[0099] (1) Pretreatment: The hydrogen peroxide sterilizer D3.1 in the sterilization chamber D starts heating and preheats and dehumidifies the inner cavity D2 of the sterilization chamber D.

[0100] (2) Sterilization: The hydrogen peroxide sterilizer D3.1 starts the sterilization program, and the atomized hydrogen peroxide aerosol is introduced into the inner cavity D2 through the fan to continuously sterilize the entire package of plastic bottles in the inner cavity D2 until the expected sterilization requirements are met. After that, the sterilization program in the hydrogen peroxide sterilizer D3.1 is turned off and left to stand for 10 minutes.

[0101] (3) Residue removal: Start the hydrogen peroxide sterilizer D3.1 residue removal program, switch the airflow to the hydrogen peroxide residue remover, and convert it into water and oxygen in the residue remover. When the hydrogen peroxide in the inner cavity D2 drops to 1ppm, the work is completed.

[0102] Step 4, unpacking:

[0103] (1) The sealing ring of the rear sliding door of the sterilizer D is leaked, and the rear sliding door is opened (closed at the front sliding door) under the action of the sliding door cylinder. The front end of the out-of-box storage rack E2 is flipped 90° to a horizontal position under the combined action of the out-of-box cylinder E4 and the out-of-box connecting rod E3, and is flush with the corresponding layer of the panel D5 of the multi-layer fixed rack D4 of the sterilizer D, which plays the role of bridging the bag.

[0104] (2) The first suction head F5 in the suction rod F is in a vacuum state, which sucks up the plastic bottles with packaging in each layer. The multiple suction rod cylinder F4 moves to move the plastic bottles with packaging backward. Then, the suction rod cylinder F3 moves to move the suction rod push plate F2 backward, and at the same time, the multiple suction rod cylinder F4 moves further backward, which sucks up all the plastic bottles with packaging in the corresponding layer of the multi-layer fixed rack D4 of the sterilization box D into the temporary storage rack E. Then, the front end of the temporary storage rack E, the discharge flip plate E2, is rotated 90° to restore its original state under the combined action of the discharge cylinder E4 and the discharge connecting rod E3. At the same time, each moving unit is restored.

[0105] Step 5, unpacking and transferring:

[0106] (1) The outgoing platform G4 in the outgoing lifting and moving platform G is adjusted up and down to the corresponding high position of the outgoing temporary storage rack E by the outgoing lifting screw G3. Then, the outgoing platform G4 moves left and right by the outgoing moving screw G2. When the outgoing platform G4 reaches the corresponding column, the outgoing docking plate G10 docks with the corresponding layer / column of the outgoing temporary storage rack E. The lifting cylinder G5 on the moving frame G8 drives the second suction head G6 to descend, so that the second suction head G6 is in the middle and front end of the packaged plastic bottle. The second suction head G6 is in a vacuum state, which sucks up the packaged plastic bottle in the corresponding position. Then, the outgoing push rod cylinder G9 drives the moving frame G8 to push forward, and at the same time, it also drives the second suction head G6 of the moving frame G8 to suck up the packaged plastic bottle in the corresponding layer and column and push it to the next process section. The bag is sucked and pushed multiple times until the packaged plastic bottle in the outgoing temporary storage rack is completely transferred.

[0107] (2) The ejection screw G2 and ejection lifting screw G3 are controlled by servo motor and PLC. Each time a package is sucked out of the ejection temporary storage rack E, the servo motor and PLC control will change the layer or column position parameters of the next package. After the package is sucked out, each motion unit returns to its original state.

[0108] The implementation principle of this invention is as follows: This invention discloses a process for transferring and sterilizing the inner bag of a multi-layer sterile plastic bottle into and out of a sterilization chamber, including: servo positioning and pushing the plastic bottle bag into the chamber during the pre-induction stage; synchronously pushing it into the sterilization chamber during the induction stage; sequentially performing preheating and dehumidification, hydrogen peroxide sterilization, and catalytic residue removal to ≤1ppm during the sterilization and residue removal stage; vacuum adsorption transfer during the out-of-chamber stage; and speed-controlled pushing to the subsequent workstation during the out-of-chamber transfer stage. This process achieves fully automated control, with precise and adjustable sterilization parameters, eliminating the risk of human contamination, and is suitable for the front-end production of veterinary drug and vaccine plastic bottle filling and sealing production lines.

[0109] The embodiments described herein are preferred embodiments of the present invention and are not intended to limit the scope of protection of the present invention. Therefore, all equivalent changes made in accordance with the structure, shape, and principle of the present invention should be covered within the scope of protection of the present invention.

Claims

1. A process for transferring and sterilizing the inner bag of a multi-layer sterile plastic bottle in and out of a sterilization chamber, characterized in that, Includes the following steps: S1. Box entry preparation: The plastic bottle package is received by the box entry lifting and moving platform (A), and after servo positioning, it is pushed into the box entry temporary storage rack (B) multi-level target position; S2, Entering the chamber: Open the front door of the sterilization chamber (D), flip the inlet flap (B2) to form a transition channel, and simultaneously push the inlet push rod (C) to push the plastic bottle pack into the multi-layer fixing rack (D4); S3. Sterilization and residue removal: Perform preheating and dehumidification, hydrogen peroxide aerosol sterilization, and residue removal sequentially until the residual concentration is ≤1ppm; S4. Unpacking: Open the rear sliding door, flip the unpacking flap (E2) to form a transition channel, and vacuum-adsorb the plastic bottle package to the unpacking temporary storage rack (E). S5. Unpacking and Transfer: The unpacking suction rod (F) picks up the plastic bottle package and transfers it to the unpacking lifting and moving platform (G) and then to the subsequent workstation.

2. The process for transferring and sterilizing the inner bag of a multi-layer sterile plastic bottle in and out of a sterilization chamber according to claim 1, characterized in that, The S1 includes the following steps: the inlet lifting and moving platform (A) drives the inlet moving screw (A2) and the inlet lifting screw (A3) through a servo motor, with a positioning accuracy of ±0.5mm, and the push rod cylinder (A8) pushes the plastic bottle packs into different layers of the inlet temporary storage rack (B) in stages.

3. The process for transferring and sterilizing the inner bag of a multi-layer sterile plastic bottle in and out of a sterilization chamber according to claim 1, characterized in that, In S2, the multiple sets of box-in push rod cylinders (C4) of the box-in push rod (C) are synchronously driven by the box-in driving cylinder (C3), with a synchronization error of ≤1ms.

4. The process for transferring and sterilizing the inner bag of a multi-layer sterile plastic bottle in and out of a sterilization chamber according to claim 1, characterized in that, S3 includes the following steps: Preheating and dehumidification: The inner cavity (D2) is heated to 40-45℃ and the humidity is reduced to below 10%RH; Sterilization: Atomize hydrogen peroxide at a concentration of 6-10 mg / L for 25-35 minutes; Residue removal: The gas stream is decomposed into H2O and O2 by the catalyst.

5. The process for transferring and sterilizing the inner bag of a multi-layer sterile plastic bottle in and out of a sterilization chamber according to claim 4, characterized in that, After sterilization, let stand for 10 minutes before starting the residue removal program.

6. The process for transferring and sterilizing the inner bag of a multi-layer sterile plastic bottle in and out of a sterilization chamber according to claim 1, characterized in that, In S4, the suction force of the first vacuum suction head (F5) is 0.06-0.08 MPa, and the synchronous movement speed of the suction rod cylinder (F4) is 0.2-0.5 m / s.

7. The process for transferring and sterilizing the inner bag of a multi-layer sterile plastic bottle in and out of a sterilization chamber according to claim 1, characterized in that, S5 includes the following steps: The box-ejection lifting platform (G) uses the second suction head (G6) to pick up the plastic bottle package; The ejector cylinder (G9) pushes the moving frame (G8) with three-stage speed adjustment.

8. The process for transferring and sterilizing the inner bag of a multi-layer sterile plastic bottle in a sterilization chamber according to any one of claims 1-7, characterized in that, After the inlet flap (B2) and outlet flap (E2) are rotated 90°, the height difference between them and the multi-layer fixing frame (D4) is ≤2mm.

9. The process for transferring and sterilizing the inner bag of a multi-layer sterile plastic bottle in and out of a sterilization chamber according to claim 8, characterized in that, The inlet flap (B2) is flipped by the inlet cylinder (B4) driving the inlet connecting rod (B3), and the outlet flap (E2) is flipped by the outlet cylinder (E4) driving the outlet connecting rod (E3), with a response time of ≤0.5s.

10. The process for transferring and sterilizing the inner bag of a multi-layer sterile plastic bottle in and out of a sterilization chamber according to claim 1, characterized in that, The entire process is controlled by a PLC, and the time interval between each step is ≤3 seconds.

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