Full-automatic intelligent sampling system for in-situ mass spectrometer

Abstract

The invention discloses a full-automatic intelligent sampling system for an in-situ mass spectrometer, and belongs to the technical field of detection devices. The system is matched with a screw pair feeding type sampling pipe, the sampling mode is hidden and portable, samples can be well protected, and the system is very suitable for various out-going sampling tasks, drug sampling for parcels, luggage, pedestrians, environments and the like or harmful substance sampling for food safety inspection. The sampling tubes are automatically and intelligently fed into an in-situ mass spectrum analyzer in batches, and a mass spectrometer is matched to obtain an analysis result according to rhythm. Aiming at the problems of tedious manual operation and low efficiency in sample injection of a screw pair feeding type sampling pipe, after automatic sample injection is adopted, the interval beat of sample injection of each sample is about 10 seconds except the detection time, and the speed can be improved by more than 100% compared with that of manual detection. Moreover, human errors are avoided, and it is ensured that each datum is associated with original sampling information through an electronic system.

Description

TECHNICAL FIELD

[0001] The application relates to a full-automatic intelligent sample feeding system for an in-situ mass spectrometer, and belongs to the technical field of detection devices. BACKGROUND

[0002] In the past work, there are relatively traditional detection of urine, blood and saliva, and now gradually mature hair biological sample detection from theory to technology. People have made great progress in the ability to detect drug traces based on the theory of analytical chemistry and laboratory complete detection equipment. The main methods include immune analysis, mass spectrometry and spectroscopy technology. However, compared with the fast detection of high-density and high-flow distribution centers, there are still some defects, such as the tendency of the subjects to refuse to provide accurate samples, the sample pretreatment is still relatively complex and even needs a special space and professional process, the drug element content of hair and other detection materials is very low, high-efficiency drug extraction technology needs to be used, many links need personnel training and professional threshold is high, and the protection of personal privacy and the traceability requirement of modern legal procedure. Many inconveniences make the existing detection scheme still unable to meet the real detection needs of accurately identifying drug suspect molecules in high-speed operation of city centers.

[0003] The situation of food safety is also not optimistic. Drug identification and food safety detection have three core needs: rapidity, high throughput and trace sampling. Rapidity means giving reliable identification results quickly; high throughput means identifying multiple substances at a time; trace sampling means giving results with less sample amount and convenient sampling.

[0004] Currently, there is no technology and product that can simultaneously meet the above three needs of drug identification or food safety detection. SUMMARY

[0005] In order to solve the problems of low efficiency of human operation process, inability to maximize the speed of the instrument, and possibility of human error in the existing technology of drug identification or food safety detection, the application provides a full-automatic intelligent sample feeding system for an in-situ mass spectrometer. The special sampling device for efficiently adsorbing and collecting trace elements, and the detection method and instrument meeting rapidity and high throughput form a matched automatic sample feeding system between the sampling device and the detection instrument. The system replaces the complicated human sample feeding operation, matches the test instrument to realize second-level detection, and can accurately match the test results to avoid human errors.

[0006] The application adopts the following technical scheme:

[0007] According to the first aspect of the application, the full-automatic intelligent sample feeding system for the in-situ mass spectrometer comprises a material sorting mechanism, a feeding and transplanting mechanism, a code scanning and rotating mechanism, a conveying robot, a probe telescoping mechanism and a material recycling mechanism.

[0008] The code scanning rotating mechanism comprises a first electric rotating clamp jaw and a two-dimensional code scanning module, the electric clamp jaw I is in different working positions according to different vertical rotation angles, and the working positions comprise a material placing position, a material receiving position, a code scanning position and a material feeding position;

[0009] The conveying manipulator comprises a first electric parallel clamp jaw and a second electric parallel clamp jaw which are symmetrically arranged in parallel;

[0010] The probe telescopic mechanism comprises a second electric rotating clamp jaw;

[0011] The ion source inlet of the in-situ mass spectrometer is located between the probe telescopic mechanism and the detection position;

[0012] The material recycling mechanism comprises a first material recycling mechanism, a second material recycling mechanism and a third material recycling mechanism;

[0013] The inlet of the first material recycling mechanism is located below the moving path of the electric parallel clamp jaw, and the second material recycling mechanism and the third material recycling mechanism are arranged side by side below the material placing position;

[0014] The sampling tube comprises a sampling tube body and a cap located at one end of the sampling tube body;

[0015] The working process of the full-automatic intelligent sampling system for the in-situ mass spectrometer comprises the following steps:

[0016] S1, the sampling tube is sorted by the sorting mechanism, the sampling tube sorted by the sorting mechanism is transported to the code scanning rotating mechanism by the feeding and transplanting mechanism, the cap at the lower end of the sampling tube is clamped by the first electric rotating clamp jaw in the material receiving position, then the first electric rotating clamp jaw drives the sampling tube to rotate to the code scanning position, and the two-dimensional code on the outer surface of the sampling tube is collected by the two-dimensional code scanning module;

[0017] S2, when the code scanning result is abnormal, the first electric rotating clamp jaw drives the sampling tube to rotate to the material placing position, the sampling tube is fed into the inlet of the third material recycling mechanism, then the first electric rotating clamp jaw rotates to the material receiving position, and the step S1 is repeated;

[0018] When the code scanning result is abnormal, the first electric rotating clamp jaw drives the sampling tube to rotate to the material feeding position, the sampling tube body is clamped by the first electric parallel clamp jaw of the conveying manipulator and is transported to the detection position, meanwhile, the cap is fed into the inlet of the second material recycling mechanism after the cap is rotated to the material placing position by the first electric rotating clamp jaw, and the step S1 is repeated;

[0019] S3, after the sampling tube reaches the detection position, the probe telescopic mechanism is lowered, and the second electric rotary clamp jaw is used to clamp and rotate the end of the sampling tube to drive the probe to extend to the ion source inlet of the in-situ mass spectrometer for detection, then the second electric rotary clamp jaw is used to clamp and rotate the end of the sampling tube to drive the probe to retract, then the first electric parallel clamp jaw clamps and releases the sampling tube body while the probe telescopic mechanism moves up, and then the first electric parallel clamp jaw clamped by the conveying manipulator clamps the sampling tube body after detection and sends it into the first material recycling mechanism inlet.

[0020] Optionally, the material sorting mechanism comprises a lifting door, a material bin and a material sorting shaft.

[0021] The lifting door is opened and closed by a hand wheel for placing the sampling tube into the material bin.

[0022] The material sorting shaft rotates the nylon rotating wheel to sort the materials.

[0023] Optionally, the capacity of the sampling tube in the material sorting mechanism is greater than or equal to 200.

[0024] Optionally, the sampling tube is selected from a spiral secondary feeding sampling tube.

[0025] Optionally, the spiral secondary feeding sampling tube is disclosed in the patent with the publication number CN118883128A.

[0026] Optionally, the feeding and transplanting mechanism comprises a synchronous belt and an angle-adjustable hopper.

[0027] The feeding and transplanting mechanism is provided with a photoelectric sensor on one end close to the hopper.

[0028] Optionally, the two-dimensional code scanning module comprises at least one embedded two-dimensional code scanning module.

[0029] Optionally, the probe telescopic mechanism is driven to move up and down by a lead screw.

[0030] Optionally, the full-automatic intelligent sampling system of the in-situ mass spectrometer is controlled by a PLC controller, drives a stepping motor and a servo motor, and controls and cooperates each structure.

[0031] Optionally, the time interval of the sampling tube into the ion source inlet of the in-situ mass spectrometer is less than 10s.

[0032] The beneficial effects of the present application include:

[0033] The application provides a full-automatic intelligent sample feeding system for an in-situ mass spectrometer, which is matched with a screw auxiliary feeding type sampling tube, the sampling method is concealed and portable, and the sampling sample can be well protected, and is very suitable for various sampling tasks, and is suitable for sampling of drugs on packages, luggage, pedestrians and environment, or sampling of harmful substances for food safety inspection, and the sampling tube is automatically and intelligently sent into the in-situ mass spectrometer in batches, and the mass spectrometer is matched to obtain analysis results according to the rhythm. In view of the problem that the sampling of the screw auxiliary feeding type sampling tube is complicated and low in efficiency, after automatic sampling, the interval of each sample is about 10 seconds, and the speed can be increased by more than 100% compared with manual detection. Moreover, human errors are avoided, and each data is associated with original sampling information through an electronic system. BRIEF DESCRIPTION OF DRAWINGS

[0034] Figure 1 It is a structure assembly diagram of the full-automatic intelligent sample feeding system.

[0035] Figure 2 It is a schematic diagram of the screw auxiliary feeding type sampling tube.

[0036] Figure 3 It is a schematic diagram of the connection between the sample feeding system and the mass spectrometer.

[0037] Figure 4 It is a schematic diagram of the material sorting mechanism.

[0038] Figure 5 It is a schematic diagram of the feeding and transplanting mechanism.

[0039] Figure 6 It is a schematic diagram of different stations (from left to right, feeding, receiving, scanning code, feeding) of the code scanning and rotating mechanism.

[0040] Figure 7 It is a schematic diagram of the conveying manipulator and the probe telescopic mechanism.

[0041] Figure 8 It is a schematic diagram of the appearance of the full-automatic intelligent sample feeding system.

[0042] IDENTIFICATION OF DRAWINGS

[0043] 1, material sorting mechanism; 11, lifting door; 12, stock bin; 13, material sorting shaft; 14, nylon rotating wheel; 15, hand wheel; 16, stepping motor and synchronous wheel; 17, inductor;

[0044] 2, feeding and transplanting machine; 21, feeding and transplanting machine servo motor; 22, speed reducer; 23, synchronous belt; 24, hopper; 25, photoelectric sensor;

[0045] 3, code scanning rotating mechanism; 31, code scanning rotating mechanism servo motor; 32, rotating platform; 33, first electric rotating clamp; 34, embedded two-dimensional scanning module;

[0046] 4, conveying manipulator; 41, first parallel electric clamp jaw; 42, second parallel electric clamp jaw;

[0047] 5, probe telescopic mechanism; 51, second electric rotating clamp jaw; 52, screw rod; 53, probe telescopic mechanism servo motor;

[0048] 61, first material recycling mechanism; 62, second material recycling mechanism; 63, third material recycling mechanism;

[0049] 7, mass spectrometer ion source inlet;

[0050] 8, touch screen;

[0051] 9, built-in PLC control. DETAILED DESCRIPTION

[0052] The present application will be described in detail below in conjunction with examples, but the present application is not limited to these examples.

[0053] Unless otherwise specified, the raw materials in the examples of the present application are purchased through commercial channels.

[0054] Unless otherwise specified, the test methods all use conventional methods, and the instrument settings all use the recommended settings of the manufacturer.

[0055] According to an embodiment of the present application, a full-automatic intelligent sampling system for an in-situ mass spectrometer includes a material sorting mechanism 1, a feeding and transplanting mechanism 2, a code scanning rotating mechanism 3, a conveying manipulator 4, a probe telescopic mechanism 5, and a material recycling mechanism. Figure 1 As shown in the figure, the sampling system includes a material sorting mechanism 1, a feeding and transplanting mechanism 2, a code scanning rotating mechanism 3, a conveying manipulator 4, a probe telescopic mechanism 5, and a material recycling mechanism.

[0056] The material sorting mechanism 1 matches the spiral pair feeding type sampling tube disclosed in the patent with publication number CN118883128A (product drawing as shown in the figure). Figure 2As shown, the sampling tube includes a cap and a sampling tube body, and a batch of sampling tubes (up to 200) after sampling are placed into the sorting mechanism at one time, and the full-automatic intelligent sampling system transports the sampling tubes one by one, and the sampling tubes are sent to the code scanning and rotating mechanism 3 through the feeding and transplanting mechanism 2 and clamped by the first electric rotating clamping jaw 33 on the code scanning and rotating mechanism 3, the code scanning and rotating mechanism 3 adjusts its posture and rotates the sampling tube along the tube axis to the code scanning position to realize the code scanning function, and then further adjusts the posture of the sampling tube to the vertical direction, the cap is pulled off by the code scanning and rotating mechanism 3, and at the same time, the transfer robot 4 clamps the cap from the code scanning and rotating mechanism 3 to the in-situ ion source inlet 7 of the mass spectrometer (when the code scanning result is abnormal, the complete sampling tube is transported to the third material recycling mechanism 63 by the code scanning and rotating mechanism 3 for recycling). After the sampling tube reaches the detection position, the probe telescoping mechanism 5 is lowered and the second electric rotating clamping jaw 51 on the probe telescoping mechanism clamps and rotates the end of the sampling tube to drive the probe in the sampling tube to extend to the in-situ ion source inlet 7 of the mass spectrometer for detection, and then the second electric rotating clamping jaw 51 clamps and rotates the end of the sampling tube to drive the probe in the sampling tube to retract, and then the probe telescoping mechanism 5 is moved upward, and the detection of the sampling tube is completed. Finally, the transfer robot 4 clamps the sampling tube after testing and transports it to the first material recycling mechanism inlet 61, and at the same time, the first electric clamping jaw 33 of the code scanning and rotating mechanism clamps the sampling tube cap left during the transfer process, rotates to the discharging position, and puts the cap into the second material recycling mechanism 62. The above process realizes the automatic sampling of the sampling tube. At the same time, the full-automatic intelligent sampling system communicates with the mass spectrometer in real time to identify the data. The connection state of the in-situ mass spectrometer and the full-automatic intelligent sampling system is as shown in Figure 3 .

[0057] As shown in Figure 4 , the sorting mechanism is composed of a lifting door 11, a material bin 12 and a sorting shaft 13. The lifting door is opened and closed by operating a hand wheel 15 to facilitate the placement of the sampling tube; the material bin 12 has a capacity greater than 200 sampling tubes, and an inductor 17 can be provided to detect the height of the sampling tube and provide information in the material bin to the user; the sorting shaft is driven by a stepper motor + synchronous wheel 16 to rotate the nylon rotating wheel 14 to sort and distribute the sampling tubes one by one into the next process.

[0058] As shown in Figure 5 , the feeding and transplanting mechanism 2 adopts a feeding and transplanting mechanism servo motor 21 + speed reducer 22 + synchronous belt 23 to drive a hopper 24. The transplanting stroke is set according to requirements, for example, 200 mm. The angle of the hopper 24 is adjustable, and the hopper has a material detection function which is detected by a photoelectric sensor 25.

[0059] As shown in Figure 6 , the rotating shaft of the code scanning and rotating mechanism 3 adopts a code scanning and rotating mechanism servo motor 31 and a rotating platform drive 32, and the rotating mechanism 3 is as shown in Figure 6 (a) to Figure 6(d) in turn is a feeding position, a receiving position, a code scanning position, a feeding position and other multiple working positions, realizing different functions. The sample tube is clamped by the first electric rotary clamp 33, which can rotate 360° infinitely. While the sample tube is rotating, a two-dimensional scanning module 34 is used to collect information by scanning the two-dimensional code of the sample tube.

[0060] As shown in Figure 7 , the conveying robot 4 is provided with two first electric parallel clamps 41 and second electric parallel clamps 42 arranged in parallel and symmetrically. The conveying shaft is driven by a servo motor and a speed reducer, and the sample tube is switched among three stations, including a code scanning station, a detection station and a recycling station, by the cooperation of the clamps.

[0061] The probe telescopic mechanism 5 is suspended above the detection station when it is not working. When needed, it is driven to descend by the servo motor 53 and the screw rod 52, and reaches the specified position. Then the second electric rotary clamp 51 clamps the end of the sample tube, and the rotary action drives the probe of the sample tube to extend and retract. The clamp can rotate 360° infinitely.

[0062] As shown in Figure 8 , the appearance of the full-automatic intelligent sample feeding system is a shell, which is provided with a touch screen 8 for control. The touch screen 8 is used to control the PLC controller built-in the full-automatic intelligent sample feeding system, to drive the stepper motor and the servo motor, and the mechanisms act in coordination according to the beat, to send the sample tube from the material sorting mechanism to the feeding and transplanting mechanism 2, then to the code scanning and rotating mechanism 3, and then to the detection station by the conveying robot 4, i.e. the ion source inlet 7 of the mass spectrometer, and finally to extend the probe of the sample tube by the probe telescopic mechanism 7 to complete the detection. After completion, the logistics recycling is performed. The corresponding information of all the process conditions is displayed on the touch screen, and the running instructions are given on the touch screen to be transmitted to the PLC.

[0063] Through the above process, the system removes the tedious manual operation through automatic sampling. The interval beat of each sample feeding is about 10 seconds, which is more than 100% faster than manual detection. Moreover, human errors are avoided, and each data is associated with its original sampling information through the electronic system.

[0064] The above is only a few embodiments of the present application, and does not limit the present application in any form. Although the preferred embodiments are disclosed above, the present application is not limited thereto. Any skilled person in the art can make some changes or modifications to the above disclosed technical contents without departing from the scope of the technical solution of the present application, which are equivalent to equivalent embodiments, and belong to the scope of the technical solution.

Claims

1. A fully automated intelligent sample introduction system for in-situ mass spectrometers, characterized in that, The fully automated intelligent sample introduction system for in-situ mass spectrometer includes: a material handling mechanism, a feeding and transfer mechanism, a barcode scanning and rotating mechanism, a conveying robot, a probe telescopic mechanism, and a material recovery mechanism; The scanning and rotating mechanism includes a first electric rotating gripper and a QR code scanning module. The electric gripper I is in different working positions according to the different vertical rotation angles. The working positions include the material feeding position, the material receiving position, the scanning position, and the material feeding position. The conveying robot includes a first electric parallel gripper and a second electric parallel gripper arranged in parallel and symmetrically. The probe telescopic mechanism includes a second electrically driven rotating gripper; The detection position is located between the ion source inlet of the in-situ mass spectrometer and the probe telescopic mechanism. The material recycling mechanism includes a first material recycling mechanism, a second material recycling mechanism, and a third material recycling mechanism; The inlet of the first material recovery mechanism is located below the moving path of the electric parallel gripper, and the second and third material recovery mechanisms are located side by side below the discharge position; The sampling tube includes a sampling tube body and a cap located at one end thereof; The working process of the fully automated intelligent sample introduction system for in-situ mass spectrometer includes: S1. The sampling tube is fed from the feeding mechanism. The feeding and transfer mechanism transports the sampling tube from the feeding mechanism to the scanning and rotating mechanism. The first electric rotating gripper at the receiving position clamps the cap at the lower end of the sampling tube. Then, the first electric rotating gripper drives the sampling tube to rotate to the scanning position and the QR code scanning module collects information from the QR code on the outer surface of the sampling tube. S2. When the scan is determined to be abnormal, the first electric rotary gripper drives the sampling tube to rotate to the discharge position and sends the sampling tube into the inlet of the third material recycling mechanism. Then, the first electric rotary gripper rotates to the receiving position and repeats step S1. When an abnormality is detected after scanning, the first electric rotary gripper drives the sampling tube to rotate to the feeding position and the first electric parallel gripper of the conveying robot grips the sampling tube body and transports it to the detection position. At the same time, the first electric rotary gripper drives the cap to rotate to the discharge position and sends the cap into the inlet of the second material recycling structure, and then repeats step S1. S3. After the sampling tube reaches the detection position, the probe telescopic mechanism descends and uses the second electric rotary gripper to clamp the end of the sampling tube and rotate it to drive the probe in the sampling tube to extend to the ion source inlet of the in-situ mass spectrometer for detection. Then, the second electric rotary gripper clamps the end of the sampling tube and rotates it to drive the probe in the sampling tube to retract. Then, the first electric parallel gripper releases the main body of the sampling tube while the probe telescopic mechanism moves upward. Then, the first electric parallel gripper of the conveying robot repeats step S2, while the second electric parallel gripper clamps the detected sampling tube body and sends it to the inlet of the first material recovery mechanism.

2. The fully automated intelligent sample introduction system for in-situ mass spectrometer according to claim 1, characterized in that, The material handling mechanism includes a lifting door, a hopper, and a material handling shaft; The lifting door is opened and closed by a handwheel to place the sampling tube into the hopper; The feeding shaft drives the nylon wheel to rotate for indexing and feeding.

3. The fully automated intelligent sample introduction system for in-situ mass spectrometer according to claim 1, characterized in that, The sampling tubes in the material handling mechanism have a capacity of 200 or more.

4. The fully automated intelligent sample introduction system for in-situ mass spectrometer according to claim 1, characterized in that, The sampling tube is selected from a spiral feed type sampling tube.

5. The fully automated intelligent sample introduction system for in-situ mass spectrometer according to claim 1, characterized in that, The feeding and transplanting mechanism includes a synchronous belt and an angle-adjustable hopper; A photoelectric sensor is installed on one end of the feeding and transplanting mechanism near the hopper.

6. The fully automated intelligent sample introduction system for in-situ mass spectrometer according to claim 1, characterized in that, The QR code scanning module includes at least one embedded QR code scanning module.

7. The fully automated intelligent sample introduction system for in-situ mass spectrometer according to claim 1, characterized in that, The probe telescopic mechanism is driven to move up and down by a lead screw.

8. The fully automated intelligent sample introduction system for in-situ mass spectrometer according to claim 1, characterized in that, The fully automated intelligent sample introduction system of the in-situ mass spectrometer uses a PLC controller to drive stepper motors and servo motors to control and coordinate the operation of each structure.

9. The fully automated intelligent sample introduction system for in-situ mass spectrometer according to claim 1, characterized in that, The time interval between introducing the sample into the ion source inlet of the in-situ mass spectrometer using a tube is less than 10 seconds.

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