Medical amorphous hydrogel and preparation method thereof
By preparing a medical amorphous hydrogel with specific components, the shortcomings of burn care materials in terms of fit, exudate management and pain relief have been solved, achieving effective wound protection and promoting healing.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-12
- Publication Date
- 2026-03-31
AI Technical Summary
Existing burn care materials are limited or inadequate in terms of fit, dynamic exudate management, active analgesia, and barrier protection, making it difficult to meet the comprehensive care needs of burn wounds.
Medical amorphous hydrogels are designed and prepared by specific components and proportions, including a gel matrix, thickener, moisturizer, preservative and neutralizer. The hydrogels with good viscoelasticity and biocompatibility are prepared by magnetic or mechanical stirring methods. They can closely adhere to the wound surface, absorb or drain exudate, and relieve pain through gel phase transition heat absorption.
It provides a continuously moist environment, significantly promotes wound healing, isolates air pollution, promotes cell migration and growth, has good moisturizing and film-forming properties, can absorb wound energy, relieve pain and reduce the risk of infection.
Smart Images
Figure CN121754715A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of medical amorphous hydrogel technology, specifically to a medical amorphous hydrogel and its preparation method. Background Technology
[0002] Burns are a common type of trauma in clinical practice. The wound healing process is affected by a variety of factors such as humidity, temperature, and infection risk. Traditional burn care materials (such as gauze and ointment dressings) have many limitations: gauze dressings have poor moisture retention and are prone to sticking to the wound, causing secondary damage when changing dressings; ointment dressings have weak liquid absorption capacity, cannot effectively handle wound exudate, are difficult to form a closed protective environment, and are susceptible to infection caused by air pollution.
[0003] Existing hydrogel protective products have a certain degree of moisturizing properties, but some products have a fixed structure and poor fit, making it difficult to adapt to burn wounds of different shapes. Moreover, most products only focus on moisturizing functions and lack targeted designs for issues such as heat absorption and pain relief in burn wounds, thus failing to meet the comprehensive needs of burn care.
[0004] Therefore, the invention of a burn wound care hydrogel that combines good moisturizing properties, fluid absorption and drainage capacity, heat absorption function, and pollution protection effect has become an important demand in the field of medical materials. Summary of the Invention
[0005] The purpose of this invention is to provide a medical amorphous hydrogel and its preparation method, so as to solve the problems of single or insufficient functions of burn and wound care materials in the above-mentioned technologies in terms of fit, dynamic exudate management, active analgesia and barrier protection.
[0006] To achieve the above objectives, the present invention provides the following technical solution: a medical amorphous hydrogel, wherein the medical amorphous hydrogel is made of the following components in the indicated mass fractions: Gel matrix: 0.2%~3%; Thickener: 0.1%~0.8%; Moisturizer: 0.8%~5%; Preservatives: 0.01%~0.4%; Neutralizing agent: 0.2%~0.5%; The remainder is purified water.
[0007] Preferably, it includes the following steps: S1: Pretreatment: Weigh the gel matrix, thickener, humectant, neutralizer, and preservative according to the preset mass fraction, and fully swell or dissolve them with different amounts of purified water; S2: Add the swollen thickener to the gel matrix solution and stir until homogeneous to obtain solution A; S3: Add the dissolved humectant to solution A and continue stirring until homogeneous to obtain solution B; S4: Add the mixed preservative to solution B and continue stirring until homogeneous to obtain solution C; S5: Add the mixed neutralizing agent to solution C and continue stirring until homogeneous to obtain the medical amorphous hydrogel.
[0008] Preferably, the stirring method in steps (2) to (5) is magnetic stirring or mechanical stirring.
[0009] Preferably, the gel matrix is one or more of sodium alginate, sodium carboxymethyl cellulose, sodium hyaluronate, chitosan, polyethylene glycol 400, polyethylene glycol 600, carbomer 934, and carbomer 940.
[0010] Preferably, the thickener is one or more of glycerol, sorbitol, carrageenan, hydroxyethyl cellulose, hydroxypropyl methylcellulose, xanthan gum, and pectin.
[0011] Preferably, the humectant is one or more of propylene glycol, 1,3-butanediol, xylitol, and urea.
[0012] Preferably, the preservative is one or more of benzoic acid, sodium benzoate, phenoxyethanol, benzalkonium chloride, potassium sorbate, and p-hydroxybenzoate.
[0013] Preferably, the neutralizing agent is one or more of sodium hydroxide, potassium hydroxide, sodium bicarbonate, hydrochloric acid, acetic acid, diethanolamine, triethanolamine, and glycine.
[0014] Preferably, the hydrogel is used as a wound care or drug delivery carrier.
[0015] The technical effects and advantages provided by the present invention in the above technical solution are as follows: 1. This invention, through the design of specific components and proportions, prepares an amorphous hydrogel with suitable viscoelasticity and stability. This system can closely conform to the contour of the wound, provide a continuous moist environment for wound healing, and efficiently absorb or drain exudate. At the same time, by utilizing the endothermic property of gel phase transition, it can absorb energy from the wound, effectively relieving pain and cooling the skin. 2. This invention selects hydrophilic polymers such as carbomer as the gel matrix and combines them with a specific preparation process to make the hydrogel have good biocompatibility, moisturizing properties and film-forming properties. This not only provides a physical protective barrier for burn wounds and isolates them from air pollution, but also creates an excellent microenvironment for cell migration and growth through hydration, thereby significantly promoting wound healing. Attached Figure Description
[0016] Figure 1 This is a schematic diagram of the process flow for the medical amorphous hydrogel of the present invention. Detailed Implementation
[0017] To enable those skilled in the art to better understand the technical solution of the present invention, the present invention will be further described in detail below with reference to the accompanying drawings.
[0018] This invention provides, for example Figure 1 The invention relates to a medical amorphous hydrogel and its preparation method, wherein the medical amorphous hydrogel is made from the following components in the indicated mass fractions: Gel matrix: 0.2%~3%; Thickener: 0.1%~0.8%; Moisturizer: 0.8%~5%; Preservatives: 0.01%~0.4%; Neutralizing agent: 0.2%~0.5%; The remainder is purified water.
[0019] Includes the following steps: Step 1: Pretreatment: Weigh the gel matrix, thickener, humectant, neutralizer, and preservative according to the preset mass fractions, and fully swell or dissolve them with different amounts of purified water; Step 2: Add the swollen thickener to the gel matrix solution and stir until homogeneous to obtain solution A; Step 3: Add the dissolved humectant to solution A and continue stirring until well mixed to obtain solution B; Step 4: Add the mixed preservative to solution B and continue stirring until homogeneous to obtain solution C; Step 5: Add the mixed neutralizing agent to solution C and continue stirring until homogeneous to obtain medical amorphous hydrogel.
[0020] The stirring methods in steps two through five are magnetic stirring or mechanical stirring.
[0021] The gel matrix is one or more of the following: sodium alginate, sodium carboxymethyl cellulose, sodium hyaluronate, chitosan, polyethylene glycol 400, polyethylene glycol 600, carbomer 934, and carbomer 940.
[0022] The thickener is one or more of the following: glycerin, sorbitol, carrageenan, hydroxyethyl cellulose, hydroxypropyl methylcellulose, xanthan gum, and pectin.
[0023] The humectant is one or more of propylene glycol, 1,3-butanediol, xylitol, and urea.
[0024] The preservative is one or more of the following: benzoic acid, sodium benzoate, phenoxyethanol, benzalkonium chloride, potassium sorbate, and p-hydroxybenzoate.
[0025] The neutralizing agent is one or more of the following: sodium hydroxide, potassium hydroxide, sodium bicarbonate, hydrochloric acid, acetic acid, diethanolamine, triethanolamine, and glycine.
[0026] Hydrogels are used as wound care or drug delivery carriers.
[0027] Example 1 This embodiment aims to provide a gel with good basic moisturizing and adhesion properties, suitable for general superficial wound care. The formula is as follows: gel matrix: sodium carboxymethyl cellulose 0.2%; thickener: carrageenan 0.3%; humectant: 1,3-butanediol 0.8%; preservative: sodium benzoate 0.02%; neutralizer: diethanolamine 0.4%; purified water: to 100%.
[0028] Preparation: Sodium carboxymethyl cellulose and carrageenan were swollen in partially purified water at room temperature for 4 hours. 1,3-Butanediol, sodium benzoate, and diethanolamine were dissolved in a small amount of water. The swollen carrageenan solution was slowly added to the sodium carboxymethyl cellulose solution under mechanical stirring at 300 rpm and stirred for 15 minutes to obtain a homogeneous viscous solution (solution A). The 1,3-Butanediol solution was added to solution A and stirred for another 10 minutes (solution B). The sodium benzoate solution was added and stirred for 5 minutes (solution C). Finally, the diethanolamine solution was slowly added dropwise, and the system gradually thickened. Stirring was continued for about 20 minutes until a smooth, transparent gel was formed.
[0029] Example 2 This embodiment focuses on using a specific matrix and humectant combination to enhance the heat absorption and cooling effect of the gel upon contact with the wound, quickly relieving pain from burns or inflammatory wounds. The formulation is as follows: Gel matrix: Carbomer 940 1.5%; Thickener: Hydroxypropyl methylcellulose 0.2%; Humectant: Propylene glycol 3.0%, Xylitol 1.0%; Preservative: Phenoxyethanol 0.3%; Neutralizing agent: Triethanolamine 0.5% (for neutralizing carbomer); Purified water: to 100%.
[0030] Preparation: Carbomer 940 was uniformly dispersed in most of purified water and allowed to swell overnight. Hydroxypropyl methylcellulose was dispersed in cold water and swelled. The remaining components were dissolved separately. The swollen hydroxypropyl methylcellulose solution was added to the carbomer 940 dispersion and stirred at 500 rpm for 20 minutes to form a homogeneous matrix (solution A). A mixed solution of propylene glycol and xylitol was added and stirred for 15 minutes (solution B). Phenoxyethanol solution was added and stirred for 5 minutes (solution C). Triethanolamine solution was added dropwise while continuously stirring at a slow speed (200 rpm). A sharp increase in viscosity and transparency of the system was observed. After continuous stirring for 30 minutes, a gel with excellent cooling sensation and high viscoelasticity was obtained.
[0031] Example 3 This embodiment introduces chitosan, which has natural antibacterial properties, as a composite matrix, combined with humectants such as urea, aiming to provide an antibacterial and epithelialization-promoting environment for wounds with high infection risk. The formula is as follows: Gel matrix: chitosan (deacetylation degree ≥90%) 1.0%, sodium hyaluronate 0.2%; Thickener: xanthan gum 0.4%; Humectant: urea 1.5%, glycerin 1.0%; Preservative: potassium sorbate 0.1%; Neutralizing agent: acetic acid 0.3% (used to dissolve chitosan), then adjust the final pH to 5.8 with an appropriate amount of sodium hydroxide; Purified water: added to 100%. Preparation: Chitosan is dissolved in a 0.3% acetic acid solution. Sodium hyaluronate and xanthan gum are swollen separately with purified water. The remaining components were dissolved; the swollen xanthan gum solution was mixed with the sodium hyaluronate solution, and chitosan acetate solution was added, and the mixture was stirred at 400 rpm for 30 minutes (solution A); a mixed solution of urea and glycerin was added, and the mixture was stirred for 15 minutes (solution B); potassium sorbate solution was added, and the mixture was stirred for 5 minutes (solution C); the pH of solution C was slowly adjusted to 5.8 with dilute sodium hydroxide solution, during which time a gel gradually formed. Finally, the mixture was stirred until homogeneous to obtain a slightly viscous antibacterial gel.
[0032] Example 4 This embodiment demonstrates the potential of the hydrogel of the present invention as a drug delivery carrier. Through a combination of high carbomer content and a specific thickener, strong cohesion and adhesion are achieved, making it suitable for scenarios requiring long-term adhesion and sustained drug release. The formulation is as follows: Gel matrix: Carbomer 934 2.5%; Thickener: Polyethylene glycol 600 0.5% (providing both thickening and softening effects); Humectant: Propylene glycol 2.0%; Preservative: Ethylparaben 0.08%; Neutralizing agent: Aminomethylpropanol (AMP-95) 0.45%; Purified water: to 100%. Preparation: Carbomer 934 is slowly sprinkled into purified water under stirring, dispersed, and allowed to swell overnight. Polyethylene glycol 600 is melted by heating and mixed with a portion of the water. Ethyl paraben was dissolved in a small amount of ethanol. A polyethylene glycol 600 solution was added to a fully swollen carbomer dispersion, and homogenized at 1000 rpm for 5 minutes, followed by mechanical stirring (600 rpm) for 15 minutes (Solution A). Propylene glycol was added and stirred for 10 minutes (Solution B). An ethanol solution of ethyl paraben was added, ensuring uniform dispersion (Solution C). AMP-95 solution was slowly added dropwise, and the system rapidly thickened. Vigorous stirring or appropriate homogenization was used to eliminate lumps, ultimately forming a clear, highly adhesive gel matrix.
[0033] All products in the examples are amorphous, non-flowing gel-like substances with a pH value between 5.5 and 7.0 (skin-compatible). They have good extensibility and can adhere closely to irregular surfaces. In constant temperature and humidity chamber tests, the gel significantly slows down moisture evaporation. When the product in Example 2 was applied to a simulated heated surface, the temperature drop was most noticeable, demonstrating excellent active cooling and analgesic effects. The gel can absorb several times its own weight in simulated exudate (physiological saline), and Example 3, containing chitosan and urea, can maintain its structure after absorbing exudate and is not easily disintegrated. Therefore, this product integrates wound adhesion, active cooling, exudate management, and barrier protection, and its formulation is flexible and can be adjusted according to different clinical needs (such as basic care, analgesia, antibacterial, and drug loading).
[0034] It should be noted that, in this document, the terms “comprising,” “including,” or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.
[0035] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.
Claims
1. A medical amorphous hydrogel, characterized by: The medical amorphous hydrogel is made of the following components with the following mass fractions: Gel matrix: 0.2%-3%; Thickening agent: 0.1%-0.8%; Moisturizing agent: 0.8%-5%; Preservative: 0.01%-0.4%; Neutralizing agent: 0.2%-0.5%; The balance is purified water.
2. A method of preparing a medical amorphous hydrogel as claimed in claim 1, characterized in that, The method comprises the following steps: S1: Pretreatment: weigh the gel matrix, thickening agent, moisturizing agent, neutralizing agent, and preservative according to the preset mass fraction, and respectively swell or dissolve with different portions of purified water; S2: add the swelled thickening agent to the gel matrix solution and stir, and obtain solution A after uniform stirring; S3: add the dissolved moisturizing agent to solution A and continue stirring, and obtain solution B after uniform stirring; S4: add the mixed preservative to solution B and continue stirring, and obtain solution C after uniform stirring; S5: add the mixed neutralizing agent to solution C and continue stirring, and obtain the medical amorphous hydrogel after uniform stirring.
3. The method for preparing a medical amorphous hydrogel according to claim 2, characterized in that: The stirring mode in steps (2)-(5) is magnetic stirring or mechanical stirring.
4. The medical amorphous hydrogel according to claim 1, characterized in that: The gel matrix is one or more of sodium alginate, sodium carboxymethyl cellulose, sodium hyaluronate, chitosan, polyethylene glycol 400, polyethylene glycol 600, carbomer 934, and carbomer 940.
5. The medical amorphous hydrogel according to claim 1, characterized in that: The thickening agent is one or more of glycerol, sorbitol, carrageenan, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, xanthan gum, and pectin.
6. The medical amorphous hydrogel according to claim 1, characterized in that: The moisturizing agent is one or more of propylene glycol, 1,3-butanediol, xylitol, and urea.
7. The medical amorphous hydrogel according to claim 1, characterized in that: The preservative is one or more of benzoic acid, sodium benzoate, phenoxyethanol, benzalkonium chloride, potassium sorbate, and p-hydroxybenzoic acid ester.
8. The medical amorphous hydrogel according to claim 1, characterized in that: The neutralizing agent is one or more of sodium hydroxide, potassium hydroxide, sodium bicarbonate, hydrochloric acid, acetic acid, diethanolamine, triethanolamine, and aminoacetic acid.
9. The medical amorphous hydrogel according to claim 1, characterized in that: The hydrogel is used for wound care or drug delivery carrier.