Automatic sample liquid absorbing, injecting and filtering mechanism

Abstract

The invention discloses an automatic sample liquid suction and injection filtering mechanism which comprises a supporting bottom plate, a supporting clamping frame is arranged on the front portion of the upper end face of the supporting bottom plate, and a reagent bottle containing tool is arranged on the side portion of the upper end face of the supporting clamping frame. When the device is used, the precision reliability is high, meanwhile, the consistency of experimental data is improved by at least 90%, the batch processing efficiency can be effectively improved, batch manufacturing can be achieved in batches, the experimental time is greatly saved, meanwhile, automatic operation can be achieved, cross contamination control can be greatly avoided, full-automatic operation can be achieved, 80% of repeated operation can be reduced, and the working efficiency is improved. The mechanical physical isolation of dangerous liquid enables safety accidents to be close to zero, can promote the overall automation rate of a laboratory to be improved by 30%-50%, and supports efficient and compliant operation of biological medicine, environmental monitoring and new material research and development.

Description

Technical Field

[0001] This invention relates to the field of laboratory equipment technology, specifically to an automatic sample aspiration, injection, and filtration mechanism. Background Technology

[0002] Liquid handling, as a fundamental and frequently performed operation in the laboratory, encompasses key steps such as sample dilution, reagent addition, and sample transfer. The quality and efficiency of its operation directly affect the reliability of experimental results and the speed of the overall experimental process. Currently, most medium and large-sized laboratories handle hundreds to thousands of liquids per day, and the traditional manual operation mode can hardly meet the needs of large-scale and high-precision experiments.

[0003] Although some semi-automatic liquid handling equipment on the market can achieve basic liquid suction and injection functions, they have the following obvious limitations:

[0004] First, it has poor compatibility. Most devices are only compatible with specific sizes of pipette tips and containers, which makes it difficult to meet the diverse experimental needs of laboratories.

[0005] Secondly, the level of intelligence is low, and it lacks the ability to link with the laboratory information management system, making it impossible to realize functions such as automatic uploading of operation data and traceability of experimental processes.

[0006] Third, the maintenance cost is high. Some core components of the equipment are expensive, and the repair costs are high. Therefore, special automated equipment is needed to fill the gap. So there is an urgent need for an automatic sample aspiration, injection and filtration mechanism to solve the above problems. Summary of the Invention

[0007] The purpose of this invention is to provide an automatic sample aspiration, injection, and filtration mechanism to solve the problems mentioned in the background art.

[0008] To achieve the above objectives, the present invention provides the following technical solution: an automatic sample aspiration, injection, and filtration mechanism, comprising a supporting base plate, a supporting bracket provided at the front of the upper end face of the supporting base plate, a reagent bottle placement fixture provided at the side of the upper end face of the supporting bracket, and reagent bottles inserted at equal intervals at the inner end face of the reagent bottle placement fixture, a stock solution bottle placement fixture provided at the side of the upper end face of the supporting bracket near the reagent bottle placement fixture, and stock solution bottles inserted at equal intervals at the inner end face of the stock solution bottle placement fixture, and two sets of consumable placement fixtures provided at the side of the supporting bracket near the stock solution bottle placement fixture, syringes provided at equal intervals at the front of the inner end face of the consumable placement fixture, and filters provided at equal intervals at the rear of the inner end face of the consumable placement fixture.

[0009] A multi-axis robot arm is fixedly mounted at the middle of the upper end face of the support base plate, and a feeding clamp for feeding and holding is provided at the output end of the multi-axis robot arm.

[0010] A liquid suction and injection filtration device is fixedly installed on one side of the upper end face of the support base plate, and a waste recycling bin is installed on the other side of the upper end face of the support base plate.

[0011] Preferably, the waste recycling bin, support bracket, and liquid suction and injection filtration device are arranged in a ring around the outside of the multi-axis robot. The waste recycling bin, support bracket, liquid suction and injection filtration device, and multi-axis robot are all modularly distributed on the upper part of the support base plate, which can effectively improve the overall adaptability of the equipment and facilitate subsequent quick basic maintenance and repair, thereby improving the practical performance of the equipment.

[0012] Preferably, the liquid suction and injection filtration device includes a support base, a support column is provided at the rear of the upper end face of the support base, and a screw module one is provided at the upper front face of the support column. A guide slide is threadedly connected to the front of the screw module one, and a Z-axis lifting module two is provided at the lower front face of the guide slide. The Z-axis lifting module one is provided at the upper front face of the guide slide, and a lifting clamp is provided at the output end of the Z-axis lifting module two, with the lifting clamp directly opposite the front face of the guide slide. A limit clamp is fixedly installed at the lowering clamp plate. An electric gripper is installed at the output end of the Z-axis lifting module one, and two sets of reagent bottle cap clamps are installed at the clamping end of the electric gripper two. A lead screw module two is installed at the front of the upper end face of the support base, and a linear slide is threaded to the upper end face of the lead screw module two. A position detection photoelectric switch is installed at both ends of the linear slide, and an electric gripper one is installed near the side of the upper end face of the linear slide. Two sets of reagent bottle clamps are installed at the clamping part of the electric gripper one.

[0013] Preferably, the upper end face of the linear slide has a raw liquid bottle placement slot facing the position detection photoelectric switch, and a reagent bottle placement slot is located on the upper end face of the linear slide facing another set of position detection photoelectric switches. The raw liquid bottle is slidably engaged inside the linear slide through the raw liquid bottle placement slot, and the reagent bottle is slidably engaged inside the linear slide through the reagent bottle placement slot. This allows the multi-axis robot to quickly and accurately position the raw liquid bottle and reagent bottle inside the linear slide using a feeding fixture, facilitating subsequent liquid extraction and injection operations.

[0014] Preferably, the two sets of reagent bottle clamps clamp and limit the sides of the reagent bottle, the limiting clamps slide and engage with the middle of the syringe, and the lifting clamp plate slides and engages with the top of the syringe. The Z-axis lifting module two drives the syringe to draw and inject liquid through the lifting clamp plate, which can effectively improve the subsequent syringe's ability to draw and inject liquid from the original liquid bottle or reagent bottle, and improve the stability of liquid drawing and injection.

[0015] Preferably, the electric gripper 2 clamps the cap on the upper part of the reagent bottle through two sets of reagent bottle cap clamps. The electric gripper 2 can clamp and limit the cap on the upper part of the reagent bottle through the reagent bottle cap clamps, which facilitates the subsequent quick and convenient cap opening operation and improves the stability and automation of cap opening.

[0016] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0017] 1. When used, this invention offers high precision and reliability, improves experimental data consistency by at least 90%, and effectively enhances batch processing efficiency, enabling batch production and significantly saving experimental time. Automated operation greatly reduces cross-contamination, and fully automated operation reduces repetitive operations by 80%. Mechanical physical isolation of hazardous liquids minimizes safety incidents and can increase the overall automation rate of laboratories by 30%-50%, supporting efficient and compliant operation in biomedicine, environmental monitoring, and new materials research and development.

[0018] 2. In this invention, the waste recycling bin, support bracket, liquid suction and injection filtration device, multi-axis manipulator, and loading fixture are all modularly designed, which can effectively improve the efficiency of subsequent inspection and maintenance, while also reducing maintenance costs. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the main body of the present invention;

[0020] Figure 2 This is a side view of the main body of the invention;

[0021] Figure 3 This is a schematic diagram of the liquid suction and injection filtration device of the present invention;

[0022] Figure 4 For the present invention Figure 3 A magnified view of a section at point III;

[0023] Figure 5 This is a side view of the liquid suction and injection filtration device of the present invention;

[0024] Figure 6 For the present invention Figure 5 A magnified view of a section at point I;

[0025] Figure 7 For the present invention Figure 5 A magnified view of section II in the middle.

[0026] In the diagram: 1-Support base plate, 2-Liquid suction, injection and filtration device, 3-Multi-axis robot arm, 4-Reagent bottle, 5-Reagent bottle placement fixture, 6-Initial solution bottle, 7-Initial solution bottle placement fixture, 8-Feeding clamp, 9-Consumables placement fixture, 10-Support bracket, 11-Injector, 12-Filter, 13-Waste recycling bin, 21-Support column, 22-Screw module one, 23-Guide slide, 24-Z-axis lifting module one, 25-Z-axis lifting module two, 26-Lifting clamp, 27-Electric gripper one, 28-Linear slide, 29-Position detection photoelectric switch, 210-Reagent bottle clamp, 211-Limit clamp, 212-Reagent bottle cap clamp, 213-Electric gripper two, 214-Screw module two, 215-Support base. Detailed Implementation

[0027] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0028] Please see Figures 1-7 This invention provides an embodiment of an automatic sample aspiration, injection, and filtration mechanism, comprising a supporting base plate 1, a supporting bracket 10 disposed at the front of the upper end face of the supporting base plate 1, a reagent bottle placement fixture 5 disposed at the side of the upper end face of the supporting bracket 10, and reagent bottles 4 equidistantly inserted into the inner end face of the reagent bottle placement fixture 5, a stock solution bottle placement fixture 7 disposed at the side of the upper end face of the supporting bracket 10 near the reagent bottle placement fixture 5, a stock solution bottle 6 equidistantly inserted into the inner end face of the stock solution bottle placement fixture 7, and two sets of consumable placement fixtures 9 disposed at the side of the supporting bracket 10 near the stock solution bottle placement fixture 7, syringes 11 equidistantly disposed at the front of the inner end face of the consumable placement fixture 9, and filters 12 equidistantly disposed at the rear of the inner end face of the consumable placement fixture 9.

[0029] The multi-axis robot 3 is fixedly installed at the middle of the upper end face of the support base plate 1, and a feeding clamp 8 for feeding is provided at the output end of the multi-axis robot 3.

[0030] Liquid suction and injection filtration device 2 is fixedly installed on one side of the upper end face of the support base plate 1, and a waste recycling box 13 is provided on the other side of the upper end face of the support base plate 1.

[0031] The waste recycling bin 13, support bracket 10, and liquid suction and injection filtration device 2 are arranged in a ring around the outside of the multi-axis robot 3. The waste recycling bin 13, support bracket 10, liquid suction and injection filtration device 2, and multi-axis robot 3 are all modularly distributed on the upper part of the support base plate 1, which can effectively improve the overall adaptability of the equipment and facilitate subsequent quick basic maintenance and repair.

[0032] The liquid suction and injection filtration device 2 includes a support base 215. A support column 21 is provided at the rear of the upper end face of the support base 215. A screw module 22 is provided at the upper front face of the support column 21. A guide slide 23 is threadedly connected to the front of the screw module 22. A Z-axis lifting module 25 is provided at the lower front face of the guide slide 23. A Z-axis lifting module 24 is provided at the upper front face of the guide slide 23. A lifting clamp 26 is provided at the output end of the Z-axis lifting module 25. A lifting clamp 26 is fixed at the position where the front face of the guide slide 23 is directly opposite the lifting clamp 26. A limit clamp 211 is provided. An electric gripper 213 is provided at the output end of the Z-axis lifting module 24. Two sets of reagent bottle cap clamps 212 are provided at the clamping end of the electric gripper 213. A lead screw module 214 is provided at the front of the upper end face of the support base 215. A linear slide 28 is threadedly connected to the upper end face of the lead screw module 214. A position detection photoelectric switch 29 is provided at both ends of the linear slide 28. An electric gripper 27 is provided near the side of the upper end face of the linear slide 28. Two sets of reagent bottle clamps 210 are provided at the clamping part of the electric gripper 27.

[0033] A raw liquid bottle placement slot is provided on the upper end face of the linear slide 28, directly opposite the position detection photoelectric switch 29. A reagent bottle placement slot is provided on the upper end face of the linear slide 28, directly opposite another set of position detection photoelectric switches 29. The raw liquid bottle 6 is slidably engaged with the inside of the linear slide 28 through the raw liquid bottle placement slot, and the reagent bottle 4 is slidably engaged with the inside of the linear slide 28 through the reagent bottle placement slot. The raw liquid bottle placement slot and the reagent bottle placement slot can facilitate the subsequent multi-axis robot 3 to quickly and accurately position the raw liquid bottle 6 and the reagent bottle 4 into the inside of the linear slide 28 through the loading clamp 8, which is convenient for subsequent liquid extraction and liquid injection operations.

[0034] Two sets of reagent bottle clamps 210 clamp and limit the sides of the reagent bottle 4, which can effectively improve the stability of the limit after the reagent bottle 4 is placed. At the same time, it can also facilitate the locking of the reagent bottle 4 when it is opened later. The limiting clamp 211 slides and engages with the middle of the syringe 11, and the lifting clamp 26 slides and engages with the top of the syringe 11. The Z-axis lifting module 25 drives the syringe 11 to draw and inject liquid through the lifting clamp 26. The limiting clamp 211 can limit the middle of the syringe 11, and the lifting clamp 26 can drive the piston rod of the syringe 11 to move up and down, which improves the stability of the subsequent liquid extraction and injection of the syringe 11 into the original liquid bottle 6 or the reagent bottle 4.

[0035] The electric gripper 213 clamps the cap on the upper part of the reagent bottle 4 through two sets of reagent bottle cap clamps 212. The electric gripper 213 can clamp and limit the cap on the upper part of the reagent bottle 4 through the reagent bottle cap clamps 212, which facilitates the subsequent quick and convenient cap opening operation and improves the stability and automation of cap opening.

[0036] Working principle: such as Figure 1 As shown, before processing, reagent bottles 4, stock solution bottles 6, syringes 11, and filters 12 can be manually or by AGV placed in the positions of reagent bottle placement fixture 5, stock solution bottle placement fixture 7, and consumables placement fixture 9.

[0037] When the photoelectric sensors at the positions of reagent bottle placement fixture 5, concentrate bottle placement fixture 7, and consumable placement fixture 9 give a positioning signal, the multi-axis robot arm 3 drives the loading fixture 8 to start. The multi-axis robot arm 3 can control the loading fixture 8 to sequentially place reagent bottle 4 and concentrate bottle 6 into the reagent bottle placement slot and concentrate bottle placement slot on the linear slide 28. Then, the multi-axis robot arm 3 drives the loading fixture 8 to place consumables, including syringe 11 and filter 12, into the lifting clamp 26 and the limiting clamp 21. After the photoelectric sensor detects the position, it issues a command. The lead screw module 214 drives the linear slide 28 to move laterally, thereby moving the fixture containing the original liquid bottle 6 and the reagent bottle 4 to the positive direction of the reagent bottle cap clamp 212 and the limiting clamp 211. At this time, the lead screw module 22 can drive the guide slide 23 to move downward. The guide slide 23 can drive the Z-axis lifting module 25, the lifting clamp 26, the electric gripper 213, and the reagent bottle cap clamp 212 to move downward synchronously. When the above equipment... After moving down to its position, the electric gripper 213 can be positioned on the side of the cap on the upper part of the reagent bottle 4 via the reagent bottle cap clamp 212, thereby enabling the reagent bottle cap clamp 212 to open the cap on the upper part of the reagent bottle 4. At the same time, the syringe 11 is inserted into the original liquid bottle 6, and the Z-axis lifting module 25 can move up via the lifting clamp 26, so that the syringe 11, which is limited inside the limiting clamp 211, can draw liquid. After the liquid drawing and cap opening / closing are completed, the linear slide 28 moves laterally. The device can move the reagent bottle 4 after opening to the injection lifting mechanism for liquid injection. At this time, the Z-axis lifting module 25 can move the lifting clamp 26 down, so that the lifting clamp 26 can cooperate with the syringe 11 inside the limiting clamp 211 to inject the liquid into the reagent bottle 4. After the liquid injection is completed, the multi-axis robot 3 drives the loading clamp 8 to put the original liquid bottle 6 and the reagent bottle 4 back into the reagent bottle and original liquid bottle placement position. At the same time, the consumables are put into the waste recycling bin 13. This process is repeated to complete the requirements.

[0038] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. An automatic sample aspiration, injection, and filtration mechanism, comprising a support base plate (1), a support bracket (10) is provided at the front of the upper end face of the support base plate (1), a reagent bottle placement fixture (5) is provided at the side of the upper end face of the support bracket (10), and reagent bottles (4) are equidistantly inserted into the inner end face of the reagent bottle placement fixture (5), a stock solution bottle placement fixture (7) is provided at the side of the upper end face of the support bracket (10) near the reagent bottle placement fixture (5), a stock solution bottle (6) is equidistantly inserted into the inner end face of the stock solution bottle placement fixture (7), and two sets of consumable placement fixtures (9) are provided at the side of the support bracket (10) near the stock solution bottle placement fixture (7), syringes (11) are equidistantly arranged at the front of the inner end face of the consumable placement fixture (9), and filters (12) are equidistantly arranged at the rear of the inner end face of the consumable placement fixture (9), characterized in that: A multi-axis manipulator (3) is fixedly installed at the middle of the upper end face of the support base plate (1), and a feeding clamp (8) for feeding is provided at the output end of the multi-axis manipulator (3). Liquid suction and injection filtration device (2) is fixedly installed on one side of the upper end face of the support base plate (1), and a waste recycling box (13) is provided on the other side of the upper end face of the support base plate (1).

2. The automatic sample aspiration, injection, and filtration mechanism according to claim 1, characterized in that: The waste recycling bin (13), support bracket (10) and liquid suction and injection filtration device (2) are arranged in a ring around the outside of the multi-axis manipulator (3).

3. The automatic sample aspiration, injection, and filtration mechanism according to claim 2, characterized in that: The liquid suction and injection filtration device (2) includes a support base (215). A support column (21) is provided at the rear of the upper end face of the support base (215). A screw module (22) is provided at the upper front face of the support column (21). A guide slide (23) is threaded to the front of the screw module (22). A Z-axis lifting module (25) is provided at the lower front face of the guide slide (23). A Z-axis lifting module (24) is provided at the upper front face of the guide slide (23). A lifting clamp (26) is provided at the output end of the Z-axis lifting module (25). The lifting clamp (26) is located at the front face of the guide slide (23) directly opposite the lifting clamp (26). A fixed limit fixture (211) is provided. An electric gripper (213) is provided at the output end of the Z-axis lifting module (24). Two sets of reagent bottle cap clamps (212) are provided at the clamping end of the electric gripper (213). A screw module (214) is provided at the front of the upper end of the support base (215). A linear slide (28) is threaded on the upper end of the screw module (214). A position detection photoelectric switch (29) is provided at both ends of the linear slide (28). An electric gripper (27) is provided near the side of the upper end of the linear slide (28). Two sets of reagent bottle clamps (210) are provided at the clamping part of the electric gripper (27).

4. The automatic sample aspiration, injection, and filtration mechanism according to claim 3, characterized in that: The upper end face of the linear slide (28) is provided with a raw liquid bottle placement slot facing the position detection photoelectric switch (29), and a reagent bottle placement slot is provided on the upper end face of the linear slide (28) facing another set of position detection photoelectric switches (29). The raw liquid bottle (6) is slidably locked inside the linear slide (28) through the raw liquid bottle placement slot, and the reagent bottle (4) is slidably locked inside the linear slide (28) through the reagent bottle placement slot.

5. The automatic sample aspiration, injection, and filtration mechanism according to claim 3, characterized in that: The two sets of reagent bottle clamps (210) clamp and limit the side of the reagent bottle (4), the limiting clamp (211) slides and engages with the middle of the syringe (11), and the lifting clamp (26) slides and engages with the top of the syringe (11). The Z-axis lifting module two (25) drives the syringe (11) to draw and inject liquid through the lifting clamp (26).

6. The automatic sample aspiration, injection, and filtration mechanism according to claim 5, characterized in that: The electric gripper 2 (213) clamps the cap on the top of the reagent bottle (4) through two sets of reagent bottle cap clamps (212).

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