Anti-CD70 nano antibody and application thereof
By developing anti-CD70 nanobodies and fusing them with the Fc fragment, the problem of poor blocking effect of existing antibodies when targeting CD70 was solved, achieving high affinity and specific tumor treatment effects and reducing immune response.
CN122080210APending Publication Date: 2026-05-26GUANGZHOU FINELMMUNE BIOTECHNOLOGY CO LTD
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Patent Information
- Application Number
- CN202610072175.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-26
- Publication Date
- 2026-05-26
AI Technical Summary
Technical Problem
Existing antibodies cannot effectively block the binding of CD70-CD27 ligand when targeting CD70, resulting in poor efficacy of tumor immunotherapy. Furthermore, the ADCC/CDC activity caused by the Fc fragment of traditional antibodies may trigger an immune response.
Method used
A novel anti-CD70 nanobody was developed that binds to CD70 and blocks its binding to CD27. Furthermore, by fusing with the Fc fragment, the half-life and binding to effector cells are increased, forming a fusion antibody that enhances the therapeutic effect.
Benefits of technology
It improves the affinity and specificity of antibodies, effectively blocks the CD70-CD27 signaling pathway, enhances the therapeutic effect of tumors, and reduces the immune response.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention belongs to the technical field of biological medicines, discloses an anti-CD70 nano antibody and application thereof, and particularly discloses an anti-CD70 nano antibody which is mainly characterized by having a CD70 binding function and being capable of blocking binding of CD70-CD27 by ligands, and a specific amino acid sequence of the anti-CD70 nano antibody is defined. The anti-CD70 nano antibody obtained by immunizing alpaca is high in affinity and strong in specificity, can be used for immunoblotting, enzyme-linked immunosorbent assay kits and flow cytometry detection and counting, and can also be used for treating diseases such as tumors and autoimmune diseases.
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