Anti-aging composition containing lactoferrin and use thereof

Abstract

The present application belongs to the technical field of cosmetics, and particularly relates to an anti-aging composition containing lactoferrin and application thereof. The anti-aging composition provided by the present application can realize synergistic effects among four components of the medicinal Fomes fomentarius extract, the Clitoria extract, the Artemisia annua extract and the lactoferrin in terms of anti-aging, achieve excellent elastase inhibition effects, prevent the degradation of elastin in the dermis, effectively reinforce the elastin scaffold, and thus improve the anti-aging effect of the composition. The anti-aging composition applied to the prepared emulsion can improve the skin firmness (R0 change rate), the skin plastic elasticity (R2 change rate) and the facial wrinkles (wrinkle change rate), has the anti-aging effect of improving wrinkle removal and skin tightening and promoting skin elasticity, and does not cause skin irritation, that is, has the characteristics of safety and mildness, has a wide application range, and has high consumer acceptance.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to an anti-aging composition containing lactoferrin and its application. Background Technology

[0002] As the largest organ in the human body, skin aging is a complex and continuous natural physiological phenomenon in the life process, mainly divided into two categories: endogenous aging and exogenous aging. Endogenous aging is controlled by individual genetics and gradually manifests with age. Its core characteristics include a gradual weakening of skin cell regeneration capacity, a decline in the proliferation capacity of keratinocytes, a reduction in the formation of the stratum corneum, a decrease in the regeneration capacity of the protective barrier, and a reduction in lipid synthesis. Ultimately, this manifests as changes in skin texture and a decrease in elasticity, and is an unavoidable natural process. Exogenous aging is mainly caused by environmental factors. External stimuli such as ultraviolet radiation, smoking, exposure to harmful chemicals, pollution, and extreme temperatures can all accelerate the aging process.

[0003] Among commonly used anti-aging active ingredients, retinol and its derivatives are the most widely used. These ingredients have strong anti-aging effects, but they are highly irritating to the skin, limiting their applicability to a limited range of people. While peptides and collagen-based anti-aging substances offer the advantages of being gentle and effective, their raw materials are expensive, and the active ingredients are not very stable, easily becoming inactive during formulation storage and use, leading to high product costs and difficulty in consistently guaranteeing efficacy. Therefore, developing anti-aging ingredients and products that combine efficacy, gentleness, stability, and cost control has become a key research focus in the industry.

[0004] With technological advancements and improved living standards, consumer demand for functional skincare products continues to grow, with a particularly strong market demand for products with anti-aging functions. This application aims to develop an anti-aging composition containing lactoferrin, which achieves both gentle and highly effective anti-aging effects through the synergistic effect of specific formulations of its components. Summary of the Invention

[0005] In view of the above-mentioned defects or improvement needs of the prior art, the present invention provides an anti-aging composition containing lactoferrin and its application, which solves the problems of strong irritation and poor anti-aging effect of existing anti-aging skin care products.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: In a first aspect, the present invention provides an anti-aging composition containing lactoferrin, comprising, by weight, the following components: Medicinal extract of *Polyporus flocculationii*: 3-7 parts; Butterfly pea flower extract: 2.5-6 parts; Artemisia annua extract: 11-15 parts; Lactoferrin: 4-9 servings.

[0007] The medicinal Fomitopsis extract in this application is a natural product extracted from medicinal Fomitopsis. It is rich in active ingredients such as polysaccharides, polyphenols, and proteins, and can reduce skin oxidative stress, inhibit inflammatory factors IL-6 and 5α-reductase, and has antioxidant, anti-inflammatory, and antibacterial biological activities.

[0008] The main active ingredients in butterfly pea flower extract include anthocyanins and flavonoids, which have good skin protection effects such as anti-oxidation, anti-inflammation, and anti-allergy. It can not only significantly reduce the level of reactive oxygen species in endothelial cells, thereby reducing oxidative stress damage to vascular endothelial cells, but also delay aging, tighten the skin, promote collagen production, and increase skin elasticity.

[0009] Artemisia annua extract is rich in artemisinin and various flavonoids, and has broad-spectrum antibacterial, anti-inflammatory and antioxidant properties.

[0010] Lactoferrin is a non-heme iron-binding glycoprotein in the transferrin family. It significantly enhances the anti-aging efficacy of anti-aging compositions by working synergistically with other components in the composition.

[0011] Preferably, the anti-aging composition comprises, by weight, the following components: Medicinal Fomitopsis extract: 5 parts; Butterfly pea flower extract: 4.5 parts; Artemisia annua extract: 13 parts; Lactoferrin: 7 servings.

[0012] Secondly, the present invention provides the use of the anti-aging composition described in the first aspect in the preparation of cosmetics with anti-aging effects.

[0013] Preferably, the cosmetic is one of the following: toner, lotion, cream, mask, or spray.

[0014] Preferably, the amount of the anti-aging composition added to the cosmetic is 0.5wt%-10wt%.

[0015] Thirdly, the present invention provides an emulsion with anti-aging effects, the emulsion comprising the anti-aging composition described in the first aspect.

[0016] Preferably, the amount of the anti-aging composition added to the emulsion is 1wt%-5wt%.

[0017] Preferably, the emulsion further comprises the following raw materials by weight percentage: 1%-10% humectant, 0.05%-0.5% thickener, 1%-5% emulsifier, 0.01%-0.3% pH adjuster, 4%-15% oil and fat and 0.5%-5% preservative, with the balance being deionized water.

[0018] More preferably, the moisturizer includes at least one of allantoin, betaine, β-glucan, trehalose, sodium hyaluronate, glycerin, D-panthenol, and ceramide.

[0019] More preferably, the thickener includes at least one of xanthan gum, carbomer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer, sclerotium gum, and cetyl alcohol.

[0020] More preferably, the emulsifier includes at least one selected from cetearyl alcohol, cetearyl glucoside, glyceryl stearate, PEG-100 stearate, behenyl alcohol, and cetearyl ester.

[0021] More preferably, the pH adjuster includes at least one of arginine, citric acid, and sodium hydroxide.

[0022] More preferably, the oil includes at least one of jojoba oil, grapeseed oil, meadowfoam seed oil, squalane, macadamia nut oil, and camellia oil.

[0023] More preferably, the preservative includes at least one selected from 1,2-propanediol, 1,2-hexanediol, phenoxyethanol, sodium benzoate, and p-hydroxyacetophenone.

[0024] The beneficial effects of this invention are: This invention provides an anti-aging composition containing lactoferrin. Through scientific compounding, the four components—medicinal Fomitopsis thunbergii extract, butterfly pea flower extract, Artemisia annua extract, and lactoferrin—can synergistically enhance anti-aging effects, achieving excellent elastase inhibition, preventing the degradation of elastin in the dermis, effectively strengthening the elastin scaffold, and thus improving the anti-aging effect of the composition.

[0025] The anti-aging composition provided by this invention can be applied to the preparation of emulsions to improve skin firmness (R0 change rate), skin plasticity and elasticity (R2 change rate) and facial wrinkles (wrinkle change rate). It has the anti-aging effects of improving wrinkle removal and firming, and promoting skin elasticity. It does not cause skin irritation, that is, it has safe and gentle properties, a wide range of applications, and high consumer acceptance. Detailed Implementation

[0026] To further illustrate the technical means and effects of the present invention in achieving the intended purpose, the following detailed description of the specific embodiments, structure, features and effects of the present invention, in conjunction with the composition, is provided below.

[0027] For the following compositions, unless otherwise specified, experimental methods are generally performed under standard conditions or as recommended by the manufacturer. Unless otherwise specified, all materials and reagents used are commercially available.

[0028] Some of the raw materials and their sources are as follows: The medicinal Fomitopsis was purchased from Anguo Xindongfang Pharmaceutical Co., Ltd. The butterfly pea flowers were purchased from Anguo City Xindongfang Pharmaceutical Co., Ltd. Artemisia annua was purchased from Anguo City New Oriental Pharmaceutical Co., Ltd.; Lactoferrin was purchased from Anguo Xindongfang Pharmaceutical Co., Ltd., and is water-soluble.

[0029] The preparation method of the medicinal fusarium extract is as follows: the fruiting body of the medicinal fusarium is dried, pulverized, and passed through a 60-mesh sieve; 50% v / v butanediol aqueous solution is added at a material-to-liquid ratio of 1g:15mL, and the mixture is refluxed at 80℃ for 2h; the mixture is filtered while hot, the filtrate is collected, and the filtrate is sterilized through a 0.22μm filter membrane to obtain the medicinal fusarium extract.

[0030] The preparation method of the butterfly pea flower extract is as follows: take dried butterfly pea flowers, pulverize them, and pass them through a 40-mesh sieve; add pure water at a material-to-liquid ratio of 1g:10mL, and extract at 60℃ for 1.5h; centrifuge (3000rpm, 15min) to collect the supernatant, and sterilize it through a 0.22μm filter membrane to obtain the butterfly pea flower extract.

[0031] The preparation method of the Artemisia annua extract is as follows: dried and pulverized Artemisia annua and passed through a 20-mesh sieve; 50% v / v butanediol aqueous solution was added at a material-to-liquid ratio of 1g:10mL, and the mixture was refluxed at 70℃ for 3h; the mixture was filtered while hot, the filtrate was collected, and the filtrate was sterilized through a 0.45μm filter membrane to obtain the Artemisia annua extract.

[0032] The component composition (parts by weight) of the compositions in Examples 1-3 of this invention is shown in Table 1 below. Each component was weighed according to the formula amount, mixed and homogenized to obtain each composition.

[0033] Table 1. Components and their weight parts of the compositions in Examples 1-3 1 5 4.5 13 7 2 7 6 15 9 3 3 2.5 11 4 Comparative Example 1 Compared with Example 1, the difference is that Comparative Example 1 does not add medicinal Fomitopsis pilosula extract, and the missing amount is made up by butterfly pea flower extract, Artemisia annua extract and lactoferrin in a weight ratio of 4.5:13:7. All other conditions and preparation methods are the same as in Example 1.

[0034] Comparative Example 2 Compared with Example 1, the difference is that butterfly pea flower extract was not added in Comparative Example 2, and the missing amount was made up with medicinal blastocystis extract, Artemisia annua extract and lactoferrin in a weight ratio of 5:13:7. All other conditions and preparation methods are the same as in Example 1.

[0035] Comparative Example 3 Compared with Example 1, the difference is that Artemisia annua extract was not added in Comparative Example 3, and the missing amount was made up by extracts of medicinal Fomitopsis pilosula, butterfly pea flower extract and lactoferrin in a weight ratio of 5:4.5:7. All other conditions and preparation methods are the same as in Example 1.

[0036] Comparative Example 4 Compared with Example 1, the difference is that lactoferrin was not added in Comparative Example 4, and the missing amount was made up by extracts of medicinal Fomitopsis pilosula, butterfly pea flower, and Artemisia annua in a weight ratio of 5:4.5:13. All other conditions and preparation methods were the same as in Example 1.

[0037] Comparative Example 5 Compared with Example 1, the difference is that the medicinal Fomitopsis pilosula extract in Comparative Example 5 was replaced with an equal amount of Fomitopsis pilosula extract, while the other conditions and preparation methods were the same as in Example 1.

[0038] Comparative Example 6 Compared with Example 1, the difference is that the Artemisia annua extract in Comparative Example 6 was replaced with an equal amount of Artemisia capillaris extract, while the other conditions and preparation methods were the same as in Example 1.

[0039] Comparative Example 7 Compared with Example 1, the difference is that the weight ratio of medicinal Fomitopsis thunbergii extract, butterfly pea flower extract, Artemisia annua extract and lactoferrin in Comparative Example 7 is 13:4.5:5:7, while other conditions and preparation methods are the same as in Example 1.

[0040] Comparative Example 8 Compared with Example 1, the difference is that the weight ratio of medicinal Fomitopsis thunbergii extract, butterfly pea flower extract, Artemisia annua extract and lactoferrin in Comparative Example 8 is 5:9:13:1, while other conditions and preparation methods are the same as in Example 1.

[0041] Example 1 of efficacy test: Composition test One of the main causes of skin aging is the alteration of the structure of the dermis. External factors such as ultraviolet radiation, stress, and pollution can activate elastase in the body, leading to excessive degradation of collagen and elastin, which support the skin structure in the dermis. Therefore, the anti-aging effect of a sample can be evaluated by testing its elastase inhibition rate.

[0042] Test samples: The compositions prepared in Examples 1-3 and Comparative Examples 1-8 were diluted with deionized water to prepare test solutions with a mass concentration of 5%; The specific experimental procedure is as follows: 1) Experimental preparation: Prepare a 0.2 mol / L Tris-HCl buffer solution with pH 8.0: Solution A: Accurately weigh 4.8456 g of Tris particles, add 100 mL of deionized water, stir and mix to dissolve to obtain a 0.4 mol / L Tris solution; Solution B: Take 3.34 mL of concentrated hydrochloric acid and dilute it with 96.66 mL of deionized water to obtain a 0.4 mol / L HCl solution; Mix 100 mL of Solution A and 44.76 mL of Solution B, adjust the pH to 8.0, and add deionized water to make up to 200 mL; Preparation of elastase solution: Prepare a 100 U / mL elastase solution using pH 8.0 Tris-HCl buffer, and prepare immediately before use; Preparation of substrate solution: Weigh 1.8057 mg N-succinyl-alanine-alanine-alanine-p-nitroaniline and dissolve it in 10 mL of pH 8.0 Tris-HCl buffer. 2) Sample loading: Blank group: 50 μL elastase solution, 100 μL substrate solution, 50 μL Tris-HCl buffer; Blank control group: 50 μL elastase solution, 150 μL Tris-HCl buffer; Sample group: 50 μL sample solution, 50 μL elastase solution, 100 μL substrate solution; Sample control group: 50 μL sample solution, 50 μL elastase solution, 100 μL Tris-HCl buffer; 3) Incubate at room temperature for 60 min, measure the absorbance at 410 nm using a microplate reader, record the data, and calculate the elastase inhibition rate using the following formula: ; Where: OD A The absorbance value of the sample group; OD B The absorbance value of the sample control group; OD C The absorbance value of the blank group; OD D The absorbance values ​​are for the blank control group; each group was measured in triplicate, and the data are presented as the average value. The specific results are shown in Table 2; Table 2. Composition Test Data Example 1 80.09 Example 2 77.35 Example 3 78.14 Comparative Example 1 59.67 Comparative Example 2 55.71 Comparative Example 3 58.40 Comparative Example 4 61.92 Comparative Example 5 69.23 Comparative Example 6 67.18 Comparative Example 7 72.95 Comparative Example 8 74.56 The results are shown in Table 2. Compared with Example 1, Comparative Examples 1-4 were missing one of the following components: medicinal Fomitopsis extract, butterfly pea flower extract, Artemisia annua extract, and lactoferrin. Comparative Example 5 used Fomitopsis pilosula extract instead of medicinal Fomitopsis extract. Comparative Example 6 used Artemisia capillaris extract instead of Artemisia annua extract. Comparative Examples 7-8 had dosage ratios of medicinal Fomitopsis extract, butterfly pea flower extract, Artemisia annua extract, and lactoferrin that were not within the scope of this application.

[0043] As can be seen from the data in Table 2, the composition provided by the technical solution of the present invention can improve the elastase inhibition rate and has excellent anti-aging effects.

[0044] As can be seen from Examples 1 and Comparisons 1-6, the effects obtained when any one of the following is missing—the extract of *Polyporus medica*, the extract of butterfly pea flower, the extract of Artemisia annua, or lactoferrin—or when one of the components is replaced by other functionally similar components, are far inferior to the effects obtained by using the technical solution of this invention. This indicates that the extract of *Polyporus medica*, the extract of butterfly pea flower, the extract of Artemisia annua, and lactoferrin promote each other in enhancing the elastase inhibition rate and have a synergistic effect.

[0045] As can be seen from Examples 1-3 and Comparative Examples 7-8, the dosage ratio of the four components in the medicinal fusiforme extract, butterfly pea flower extract, Artemisia annua extract, and lactoferrin also affects the elastase inhibition rate of the composition, thereby affecting the anti-aging effect of the composition. Among them, when the weight ratio of the medicinal fusiforme extract, butterfly pea flower extract, Artemisia annua extract, and lactoferrin is (3-7):(2.5-6):(11-15):(4-9), the composition provided by the present invention has a better anti-aging effect. Furthermore, when the dosage ratio of the medicinal fusiforme extract, butterfly pea flower extract, Artemisia annua extract, and lactoferrin is 5:4.5:13:7, the four components promote each other and work together in terms of skin anti-aging efficacy, thereby achieving the optimal effect of the composition.

[0046] Emulsions from Application Examples 1-3 and Comparative Application Examples 1-8 The compositions prepared in Examples 1-3 and Comparative Examples 1-8 were added to the emulsion at a concentration of 5 wt% to obtain the emulsions of Application Examples 1-3 and Comparative Application Examples 1-8. The formulations are shown in Table 3.

[0047] The method for preparing the emulsion specifically includes the following steps: Thickener and humectant are mixed evenly, deionized water is added, and the mixture is heated at 80°C for 12 minutes and homogenized at 4500 rpm for 5 minutes. After homogenization, the mixture is kept warm for later use to obtain mixture A. Oil and emulsifier are mixed, heated to 75°C, dissolved evenly, and kept warm for later use to obtain mixture B. Mixture A and mixture B are mixed and homogenized at 4500 rpm for 5 minutes to obtain mixture C. Mixture C is cooled to 50°C, and the components of the composition are added. The mixture is stirred evenly, and then preservative and pH adjuster are added. The stirring is stopped, and the mixture is discharged to obtain the emulsion.

[0048] Table 3. Emulsion formulations of Application Examples 1-3 and Comparative Application Examples 1-8

[0049] Blank application example: Compared with application examples 1-3, the difference is that the emulsion in the blank application example does not contain an anti-aging composition, and an equal amount of deionized water is used instead of the anti-aging composition. The preparation method is the same as that in application examples 1-3.

[0050] Example 2 of efficacy test: Human efficacy trial The anti-aging effects of emulsions prepared in Application Examples 1-3, Comparative Application Examples 1-8, and Blank Application Examples were tested.

[0051] The testing method is as follows: 120 participants aged 20-45 were randomly selected and divided into 12 groups of 10 each. The 12 groups of participants used the lotions prepared in Application Examples 1-3, Control Application Examples 1-8, and Blank Application Examples, respectively, twice a day, morning and evening, with each application being 1g, for 30 days. During the trial, the participants were not allowed to use other products that maintain skin elasticity or cosmetics that could affect the determination of the results, and their original dietary habits were not changed during the trial. The skin condition was tested on day 0 and day 30 using a Cutometer MPA 580 skin elastometer. The test area was the cheekbone region. The test parameters were skin firmness R0 (reflecting the skin's passive response to external force; the smaller the R0 value, the firmer the skin) and skin elasticity R2 (the ratio of the skin's rebound amount Ua under no negative pressure to the maximum stretch amount Uf under negative pressure; the closer R2 is to 1, the better the skin's elasticity). The rate of change of R0 and R2 was calculated using the following formula: ; In the formula: A 第0天 For each group, the data for R0 before use (day 0); A 第30天 Data for R0 after use (day 30) for each group; ; In the formula: B 第0天 For each group, the R² data is the data before use (day 0); B 第30天 The data for R2 after use (day 30) for each group; The VISIA facial image analyzer was used to measure the user's facial wrinkle score on day 0 and day 30, reflecting the size, area, and density of wrinkles. The lower the score, the fewer the wrinkles. The wrinkle change rate was calculated using the following formula: ; In the formula: C 第0天 Data on facial wrinkles (including front, left, and right sides) before use in each group (day 0); C 第30天 Data on facial wrinkles after use (day 30) for each group; The specific test results are shown in Table 4. As can be seen from the data in Table 4, the product provided by the technical solution of this invention can improve skin firmness (R0 change rate), skin plasticity and elasticity (R2 change rate) and facial wrinkles (wrinkle change rate), and has anti-aging effects of improving wrinkle removal and firming, and promoting skin elasticity.

[0052] As can be seen from Application Example 1 and Comparative Application Examples 1-6, the effects obtained are far inferior to those obtained by using the technical solution of this invention, whether any one of the following is missing: medicinal Fomitopsis pilosula extract, butterfly pea flower extract, Artemisia annua extract, or lactoferrin, or when one of the components is replaced by other functionally similar components. This indicates that medicinal Fomitopsis pilosula extract, butterfly pea flower extract, Artemisia annua extract, and lactoferrin promote each other in their anti-wrinkle, firming, and skin elasticity-enhancing effects, and have a synergistic effect.

[0053] As can be seen from Application Examples 1-3 and Comparative Application Examples 7-8, the ratio of the four components in the medicinal fusiforme extract, butterfly pea flower extract, Artemisia annua extract, and lactoferrin also affects the anti-aging effect of the emulsion. Among them, when the weight ratio of the medicinal fusiforme extract, butterfly pea flower extract, Artemisia annua extract, and lactoferrin is (3-7):(2.5-6):(11-15):(4-9), the emulsion provided by the present invention has a better anti-aging effect. Furthermore, when the ratio of the medicinal fusiforme extract, butterfly pea flower extract, Artemisia annua extract, and lactoferrin is 5:4.5:13:7, the four components promote each other and work together in terms of skin anti-aging efficacy, thereby achieving the optimal effect when applied to the prepared emulsion.

[0054] Table 4 Human Efficacy Test Data Blank application example 1.04 1.52 2.46 Application Example 1 17.56 14.27 26.08 Application Example 2 15.19 13.41 23.62 Application Example 3 16.35 12.70 24.84 Comparative Application Example 1 5.22 6.23 12.59 Comparative Application Example 2 6.47 5.19 9.30 Comparative Application Example 3 8.21 7.86 14.57 Comparative Application Example 4 7.60 7.02 11.21 Comparative Application Example 5 10.38 9.17 17.36 Comparative Application Example 6 11.92 9.95 18.24 Comparative Application Example 7 13.27 10.81 20.03 Comparative Application Example 8 12.43 11.56 21.85 Example 3: Patch Test The emulsions prepared in Application Examples 1-3 and the blank application example were used as samples to verify their safety on human skin. In accordance with the "Cosmetic Safety Technical Specifications" (2015 edition) for human skin patch testing, 40 volunteers aged 18-50 years were recruited for the experiment. The test environment was a temperature of (21±1)℃ and a humidity of (50±10)%, with 10 people in each group. The volunteers washed their forearms with clean water. After 5-10 minutes, when the moisture on the forearms had evaporated, the testers applied 0.025mg of each sample to each chamber of a 10-well patch tester. The inner sides of the volunteers' two forearms were selected, avoiding the skin at the joints of the front and back of the hands. Each arm was covered with a patch tester and marked accordingly. The patch application time lasted for 24 hours. The patch testers were removed and the residual sample was wiped off. The skin reaction was observed at 0.5h, 24h, and 48h. The test results were recorded according to the adverse skin reaction grading standards in Table 5.

[0055] Table 5. Adverse skin reaction levels 0 negative reaction 1 Suspicious reaction, only slight erythema 2 Weak positive reaction (erythema reaction): erythema, infiltration, edema, and papules may be present. 3 Strong positive reaction (herpes reaction): erythema, infiltration, edema, papules; the reaction may extend beyond the test area. 4 Extremely strong positive reaction (confluent herpes simplex reaction): obvious erythema, severe infiltration, edema, confluent herpes simplex; reaction extends beyond the test area. The results showed that the adverse reaction scores of the skin at three observation time points (0.5h, 24h, and 48h) after patch removal were all 0 in the four groups of volunteers. According to the provisions of the "Cosmetic Safety Technical Specifications" (2015 edition), the lotions prepared by the present invention in Application Examples 1-3 and the blank application example did not cause adverse skin reactions in this batch of volunteers, indicating that they are safe and non-irritating to human skin.

[0056] The above description is merely a preferred composition of the present invention and is not intended to limit the present invention in any way. Although the present invention has been disclosed above with preferred compositions, it is not intended to limit the present invention. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent compositions without departing from the scope of the present invention. Any simple modifications, equivalent changes and alterations made to the above compositions based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.

Claims

1. An anti-aging composition containing lactoferrin, characterized in that, By weight, it includes the following components: Medicinal Fomitopsis pinnatifida extract: 3-7 parts; Butterfly pea flower extract: 2.5-6 parts; Artemisia annua extract: 11-15 parts; Lactoferrin: 4-9 parts; The preparation method of the medicinal fumonis extract is as follows: the fruiting body of medicinal fumonis is dried, pulverized, and passed through a 60-mesh sieve; 50% v / v butanediol aqueous solution is added at a material-to-liquid ratio of 1g:15mL, and the mixture is refluxed at 80℃ for 2h; the mixture is filtered while hot, the filtrate is collected, and the filtrate is sterilized through a 0.22μm filter membrane to obtain the medicinal fumonis extract; The preparation method of the butterfly pea flower extract is as follows: take dried butterfly pea flowers, pulverize them, and pass them through a 40-mesh sieve; add pure water at a material-to-liquid ratio of 1g:10mL, and extract at 60℃ for 1.5h; after centrifugation at 3000rpm for 15min, take the supernatant, and sterilize it through a 0.22μm filter membrane to obtain the butterfly pea flower extract. The preparation method of the Artemisia annua extract is as follows: dried and pulverized Artemisia annua and passed through a 20-mesh sieve; 50% v / v butanediol aqueous solution was added at a material-to-liquid ratio of 1g:10mL, and the mixture was refluxed at 70℃ for 3h; the mixture was filtered while hot, the filtrate was collected, and the filtrate was sterilized through a 0.45μm filter membrane to obtain the Artemisia annua extract.

2. The anti-aging composition according to claim 1, characterized in that, By weight, it includes the following components: Medicinal Fomitopsis extract: 5 parts; Butterfly pea flower extract: 4.5 parts; Artemisia annua extract: 13 parts; Lactoferrin: 7 servings.

3. The use of the anti-aging composition according to claim 1 or 2 in the preparation of cosmetics with anti-aging effects, characterized in that, The cosmetic product is one of the following: toner, lotion, cream, mask, or spray.

4. The application as described in claim 3, characterized in that, The anti-aging composition is added to the cosmetic at a rate of 0.5wt%-10wt%.

5. An emulsion with anti-aging effects, characterized in that, The emulsion comprises the anti-aging composition as described in claim 1 or 2.

6. The emulsion as described in claim 5, characterized in that, The anti-aging composition is added to the emulsion at an amount of 5wt%-10wt%.

7. The emulsion as described in claim 6, characterized in that, The emulsion also includes the following ingredients by weight percentage: 1%-10% humectant, 0.05%-0.5% thickener, 1%-5% emulsifier, 0.01%-0.3% pH adjuster, 4%-15% oil and fat, and 0.5%-5% preservative, with the balance being deionized water.

8. The emulsion as described in claim 7, characterized in that, The moisturizer includes at least one of allantoin, betaine, beta-glucan, trehalose, sodium hyaluronate, glycerin, D-panthenol, and ceramide; The thickener includes at least one of xanthan gum, carbomer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer, sclerotium gum, and cetyl alcohol; The emulsifier includes at least one of cetearyl alcohol, cetearyl glucoside, glyceryl stearate, PEG-100 stearate, and behenyl alcohol; The pH adjuster includes at least one of arginine, citric acid, and sodium hydroxide; The oils include at least one of jojoba oil, grapeseed oil, meadowfoam seed oil, squalane, macadamia nut oil, and camellia oil; The preservative includes at least one of 1,2-propanediol, 1,2-hexanediol, phenoxyethanol, sodium benzoate, and p-hydroxyacetophenone.

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