Application of pharmaceutical composition in the process for preparing medicine to counteract aspirin resisting medicine

Abstract

The invention relates to the application of pharmaceutical composition in the process for preparing medicine to treat aspirin resistance, wherein the pharmaceutical composition comprises (by weight ratio) ginseng stems and leaves saponin 8-20 wt. units, root of herbaceous peony 1000-2500 weight parts.

Description

technical field

[0001] The invention belongs to the field of medicine, and in particular relates to the application of a pharmaceutical composition in the preparation of anti-aspirin resistance drugs. Background technique

[0002] Aspirin (Aspirin), also aspirin or acetylsalicylic acid, has been used clinically for more than 80 years and is an ancient antipyretic and analgesic. In recent years, with the in-depth research on prostaglandins, new understandings have been gained on aspirin: in addition to being traditionally used for antipyretic, analgesic and anti-inflammatory, it is also used for anti-platelet aggregation in clinical practice. Clinical trials have shown that aspirin is an effective antiplatelet drug for the primary prevention of high-risk patients with cardiovascular and cerebrovascular diseases, and is also effective for the secondary prevention of myocardial infarction and ischemic vascular events.

[0003] However, at presen...

Examples

Embodiment 1

[0103] Take the Radix Paeoniae Alba in the amount of raw materials, add water and decoct 2-4 times, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.20-1.50 (50°C), dry, powder into fine powder, and then add the Ginseng stem and leaf saponins and 20-80 weight units of stevioside fine powder (sweetener) and 1-10 weight units of starch are granulated with 60%-80% ethanol, dried, and packed into capsules (each About 0.25g of medicine is filled in the capsule), and the product is obtained.

Embodiment 2

[0105] Take the Radix Paeoniae Alba in the amount of raw materials, add water and decoct 2-4 times, combine the decoction, filter, concentrate the filtrate under reduced pressure to a relative density of 1.20-1.50 (50°C), dry, powder into fine powder, and then add it to the amount of raw materials in turn Ginseng stem and leaf saponins and 20-60 weight units of stevioside fine powder (sweetener) and 1-10 weight units of starch are granulated with 60%-80% ethanol, dried, and magnesium stearate is added 1-5 weight units, mixed evenly, pressed into tablets (core weight 0.39 / tablet), and then coating the core with sugar (15-20kg of white granulated sugar for each kg of tablet core, 14-20kg of talcum powder, polished) , the product is obtained.

technical field

[0001] The invention belongs to the field of medicine, and in particular relates to the application of a pharmaceutical composition in the preparation of anti-aspirin resistance drugs. Background technique

[0002] Aspirin (Aspirin), also aspirin or acetylsalicylic acid, has been used clinically for more than 80 years and is an ancient antipyretic and analgesic. In recent years, with the in-depth research on prostaglandins, new understandings have been gained on aspirin: in addition to being traditionally used for antipyretic, analgesic and anti-inflammatory, it is also used for anti-platelet aggregation in clinical practice. Clinical trials have shown that aspirin is an effective antiplatelet drug for the primary prevention of high-risk patients with cardiovascular and cerebrovascular diseases, and is also effective for the secondary prevention of myocardial infarction and ischemic vascular events.

[0003] However, at presen...

Examples

Embodiment 1

[0103] Take the Radix Paeoniae Alba in the amount of raw materials, add water and decoct 2-4 times, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.20-1.50 (50°C), dry, powder into fine powder, and then add the Ginseng stem and leaf saponins and 20-80 weight units of stevioside fine powder (sweetener) and 1-10 weight units of starch are granulated with 60%-80% ethanol, dried, and packed into capsules (each About 0.25g of medicine is filled in the capsule), and the product is obtained.

Embodiment 2

[0105] Take the Radix Paeoniae Alba in the amount of raw materials, add water and decoct 2-4 times, combine the decoction, filter, concentrate the filtrate under reduced pressure to a relative density of 1.20-1.50 (50°C), dry, powder into fine powder, and then add it to the amount of raw materials in turn Ginseng stem and leaf saponins and 20-60 weight units of stevioside fine powder (sweetener) and 1-10 weight units of starch are granulated with 60%-80% ethanol, dried, and magnesium stearate is added 1-5 weight units, mixed evenly, pressed into tablets (core weight 0.39 / tablet), and then coating the core with sugar (15-20kg of white granulated sugar for each kg of tablet core, 14-20kg of talcum powder, polished) , the product is obtained.