Temperature detection device for simulating temperature of reagent

Abstract

The utility model belongs to the technical field of temperature detection device manufacturing, and discloses a temperature detection device for simulating reagent temperature, which comprises a bottle body for simulating reagent packaging environment, liquid for simulating reagent is filled in a bottle cavity of the bottle body, a bottle opening of the bottle body is sealed through a sealing cover, and the sealing cover is connected with a temperature sensor. The temperature sensor is in liquid contact with the simulation reagent and is connected with the signal transmission line. By detecting the temperature of the reagent, the problem of false alarm caused by instant temperature rise during door opening of the refrigerator is effectively avoided, the accuracy of temperature monitoring is improved, the problem of delay possibly caused by adopting a fixed delay method is avoided, accurate feedback of reagent temperature change is ensured, and safe use of the medicine reagent is guaranteed; and the temperature sensor and the sealing cover are tightly combined in an integral injection molding manner, so that the structure of the device is simplified, possible connecting points and components are reduced, the sealing performance of the device is improved, and the temperature sensor is ensured to more accurately reflect the actual temperature of a reagent.

Description

Technical Field

[0001] The utility model belongs to the technical field of temperature detection device manufacturing, in particular to a temperature detection device for simulating reagent temperature. Background Art

[0002] During the drug development process, after the development is completed, and before the use of drug reagents, the installation, transportation, and storage of reagents and drugs will be involved. In order to ensure the safe use of drug reagents, there are very strict requirements for the temperature of reagent transportation and storage, and the collection of temperature signals is the source and key to achieve real-time monitoring of reagent storage temperature. For reagent transportation, storage, and use, the collected temperature signal must accurately and timely reflect the actual temperature of the reagent.

[0003] At present, the reagent temperature control system places the sensor directly in the storage environment of the refrigerator, but the temperature it collects is actually the ambient temperature of the refrigerator storage, not the actual temperature of the reagent. Because, during the storage process of the reagent, when the refrigerator or freezer is opened, the temperature inside the refrigerator or freezer will rise instantly. If the refrigerator or freezer is opened for a short time, this short temperature rise may not necessarily lead to an increase in the actual temperature of the reagent. However, the temperature control system detects the temperature rise data because it detects the entire internal ambient temperature of the refrigerator or freezer, which may cause a false alarm.

[0004] At present, a Chinese patent document with a patent authorization announcement number of CN 201666822 U discloses a cold chain temperature detection device that simulates the temperature of a vaccine, including a bottle body that simulates the vaccine packaging environment, the interior of the bottle body is divided into an environmental cavity and a liquid cavity by a partition wall, the liquid cavity contains a liquid that simulates the vaccine, and the environmental cavity and the liquid cavity are sealed by a sealing cover respectively; a temperature sensor is arranged in the environmental cavity of the bottle body, the temperature sensor is close to the partition wall, and the temperature sensor is connected to a signal transmission line. By simulating the vaccine and its packaging environment, the actual temperature of the vaccine can be accurately detected and reflected, thereby avoiding false alarms caused by the instantaneous temperature rise when the refrigerator or freezer door is opened. However, in this technical solution, there is still an error in the temperature of the environmental cavity and the liquid cavity detected by the temperature sensor, so it is necessary to optimize it.

[0005] Other existing technologies solve the aforementioned false alarm problem by using a fixed delay method. Since the time when the refrigerator or freezer door is opened cannot be determined, and the heat capacity of each refrigerator or freezer is different, the fixed alarm delay method may delay the time when the alarm is really needed. Therefore, the existing reagent temperature control system cannot accurately reflect whether the temperature rise caused by opening the refrigerator or freezer door has a real impact on the reagent, which may cause false alarms, and the existing fixed delay method will delay the alarm timing. The present utility model is proposed based on this current situation, in order to solve the problems existing in the prior art by detecting the temperature of the reagent itself rather than the ambient temperature in the refrigerator or freezer. Summary of the invention

[0006] In view of the above technical problems, the utility model provides a temperature detection device for simulating the temperature of a reagent by optimizing and improving on the basis of the Chinese patent document with announcement number CN 201666822 U. The temperature detection device improves the accuracy of detecting the temperature of the reagent by detecting the temperature of the reagent itself rather than the ambient temperature in the refrigerator or freezer.

[0007] The above technical objectives of the utility model are achieved through the following technical solutions:

[0008] A temperature detection device for simulating reagent temperature includes a bottle body simulating the reagent packaging environment, a bottle cavity of the bottle body filled with liquid simulating the reagent, a bottle mouth of the bottle body sealed by a sealing cover, the sealing cover is connected to a temperature sensor, the temperature sensor is in contact with the liquid simulating the reagent, and the temperature sensor is connected to a signal transmission line.

[0009] By adopting the above technical solution, by detecting the temperature of the reagent itself rather than the ambient temperature, the false alarm problem caused by the instantaneous temperature rise when the refrigerator door is opened is avoided, and the device structure is simplified, the sealing is improved, and the temperature sensor is ensured to more accurately reflect the actual temperature of the reagent. The delay problem that may be caused by the fixed delay method is avoided, and the reagent temperature change is fed back in a timely and accurate manner to ensure the safe use of pharmaceutical reagents.

[0010] It is further provided that the temperature sensor and the sealing cover are injection molded into one piece.

[0011] It is further arranged that the temperature sensor is located at the central axis of the bottle body.

[0012] It is further arranged that the temperature sensor is located at the center of the sealing cover, and the temperature sensor does not contact the bottom of the bottle body.

[0013] By adopting the above technical solution, the one-piece injection molding method improves the tight integration of the sealing cover and the temperature sensor, enhances the sealing and stability of the device, and can prevent external conditions from interfering with temperature monitoring. By setting the temperature sensor on the central axis of the bottle body and keeping a proper distance from the bottom, uniform contact and more accurate monitoring of the overall temperature of the reagent are achieved, thereby improving the reliability of the monitoring system.

[0014] It is further provided that the signal transmission line is integrally formed with the sealing cover by injection molding and extends outside the bottle body.

[0015] By adopting the above technical solution, the signal transmission line and the sealing cover are seamlessly combined by one-piece injection molding, reducing the risk of possible connection problems and improving the safety of the entire device. The signal transmission line extends outside the bottle body, providing more flexible external connection options, making the device easier to integrate into different monitoring systems or data acquisition equipment. The extended signal transmission line provides a convenient interface for the device, which can be easily connected to the external monitoring system to achieve real-time transmission and recording of temperature data.

[0016] It is further provided that a sealing gasket is provided between the sealing cover and the bottle body.

[0017] By adopting the above technical solution, the sealing gasket is arranged between the sealing cover and the bottle body, forming a more tightly closed structure, effectively preventing the entry of external air, moisture or dust and other substances, and improving the sealing of the entire device. The sealing gasket has a certain elasticity and adaptability, can adapt to different environmental conditions, increase the stability of the connection part, and reduce the possibility of poor sealing caused by factors such as temperature changes. The sealing gasket can also reduce the potential risk of corrosion or damage, extend the service life of the device, and improve the durability of the device.

[0018] It is further arranged that the bottle mouth forms an external thread, the sealing cover forms an internal thread, and the internal thread cooperates with the external thread.

[0019] By adopting the above technical solution, the sealing cap can be tightly screwed on the bottle mouth through the external thread and the internal thread to form an effective seal, thereby preventing external air, moisture or dust and other substances from entering the bottle body, ensuring that the reagent is in a good closed environment. The threaded structure enables the user to easily open or close the bottle mouth by rotating the sealing cap, making it easy to load and remove the reagent, and improving the convenience of use.

[0020] It is further arranged that the liquid of the simulation reagent is propylene glycol.

[0021] By adopting the above technical solution, propylene glycol is non-toxic, tasteless and resistant to low temperatures. It can reach -40°C without solidifying, and the temperature of propylene glycol is the same as the temperature of the actual reagent, so it can accurately reflect the actual temperature of the reagent. Propylene glycol is a stable compound that responds relatively slowly to temperature changes, thereby ensuring the stability of the reagent temperature and avoiding changes in the properties of the reagent due to temperature fluctuations, thereby maintaining the accuracy and reliability of the reagent. Propylene glycol has good thermal conductivity and can effectively conduct temperature. It is very critical to ensure that the temperature sensor accurately reflects the actual temperature of the reagent, thereby improving the accuracy of temperature detection. Propylene glycol is not easily lost in the environment, avoiding the problem of changes in reagent concentration or failure due to volatilization.

[0022] It is further provided that the bottle body is made of high borosilicate glass material.

[0023] By adopting the above technical solution, high borosilicate glass is a special glass material with excellent temperature resistance, which enables the device to maintain stability under different temperature conditions and adapt to various environments, especially in application scenarios with large temperature fluctuations. High borosilicate glass also has good chemical stability, can withstand the erosion of a variety of chemical substances, and can prevent adverse reactions between reagents and bottles. High borosilicate glass has good resistance to moisture, acid and alkali, etc., which reduces the possibility of corrosion of the bottle due to external environmental factors and prolongs the service life of the device.

[0024] It is further provided that the sealing gasket is made of food-grade silicone material.

[0025] By adopting the above technical solution, the sealing gasket is made of food-grade silicone material, which ensures the safety of contact with the reagent, does not cause contamination or harmful reactions to the reagent, and meets the hygiene standards of pharmaceutical reagents. Food-grade silicone material has good chemical stability, can maintain its performance under different temperature and humidity conditions, and will not dissolve or damage the material due to the nature of the reagent. Food-grade silicone material usually has high temperature resistance, can adapt to temperature fluctuations, maintain elasticity and sealing, and enhances the stability of the sealing gasket under different environmental conditions.

[0026] It is further configured that the temperature sensor is a high-precision NTC thermal resistor that is integrally formed and injection-molded with TPE material.

[0027] By adopting the above technical solution and using high-precision NTC thermal resistors as temperature sensors, the accuracy of temperature detection is improved, thereby improving the high sensitivity and precise response to changes in reagent temperature. The one-piece injection molding design of TPE material simplifies the structure of the sensor, reduces possible connection points and components, and improves the stability and reliability of the sensor. TPE material has good durability and wear resistance, can maintain the performance of the sensor under different working environments, and extend the service life of the sensor.

[0028] It is further provided that the sealing cover is made of reinforced nylon material by injection molding.

[0029] By adopting the above technical solution, the sealing cover made of injection-molded reinforced nylon material has a higher structural strength, which can better protect the internal components of the device and reduce the risk of structural damage caused by changes in the external environment. The use of reinforced nylon material can also improve the durability of the sealing cover, so that the sealing cover can better withstand long-term use and temperature changes without failure, thereby extending the life of the device. The reinforced nylon material can also improve the overall stability of the sealing cover, ensuring that the sealing cover can maintain good performance under various working conditions.

[0030] In summary, the utility model has the following beneficial effects:

[0031] 1. The utility model effectively avoids the problem of false alarm caused by the instantaneous temperature rise when the refrigerator door is opened by detecting the temperature of the reagent itself rather than the ambient temperature, improves the accuracy of temperature monitoring, avoids the delay problem that may be caused by the use of a fixed delay method, ensures timely and accurate feedback on the temperature change of the reagent, and ensures the safe use of pharmaceutical reagents.

[0032] 2. The utility model tightly combines the temperature sensor and the sealing cover by integral injection molding, thereby enhancing the sealing and stability of the device, effectively preventing external conditions from interfering with temperature monitoring, simplifying the structure of the device, reducing possible connection points and components, improving the sealing of the device, and ensuring that the temperature sensor more accurately reflects the actual temperature of the reagent.

[0033] 3. The present invention reduces the risk of possible connection problems and improves the safety of the entire device by injection molding the signal transmission line and the sealing cover into one piece and extending them outside the bottle body. At the same time, the extended signal transmission line provides the device with more flexible external connection options, making the device easier to integrate into different monitoring systems or data acquisition equipment. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Figure 1 It is a schematic structural diagram of a temperature detection device for simulating the temperature of a reagent in a preferred embodiment;

[0035] Figure 2 It is a structural schematic diagram of the sealing cover and the temperature sensor;

[0036] Figure 3 is a cross-sectional view of the sealing cover and the temperature sensor;

[0037] Figure 4 is a diagram of the erected state of a temperature detection device simulating the temperature of a reagent according to a preferred embodiment;

[0038] Figure 5 It is a horizontal state diagram of a temperature detection device for simulating reagent temperature in a preferred embodiment.

[0039] Figure numerals: 1, bottle body; 2, bottle mouth; 3, bottle cavity; 4, sealing cover; 5, temperature sensor; 6, sealing gasket; 7, signal transmission line. DETAILED DESCRIPTION

[0040] The preferred embodiments of the present utility model are described in detail below in conjunction with the accompanying drawings.

[0041] like Figure 1-3As shown, a preferred embodiment of a temperature detection device for simulating the temperature of a reagent comprises a bottle body 1 for simulating the packaging environment of the reagent, a bottle cavity 3 of the bottle body 1 is filled with a liquid of the simulating reagent, a bottle mouth 2 of the bottle body 1 is sealed by a sealing cover 4, the sealing cover 4 is connected to a temperature sensor 5, and the temperature sensor 5 is connected to a signal transmission line 7. The temperature of the simulated reagent is detected by the temperature sensor 5 to prevent the reagent from being affected by the ambient temperature in the refrigerator or freezer. The temperature sensor 5 is located on the central axis of the bottle body 1, in contact with the reagent, and transmits the temperature data to the monitoring system through the signal transmission line 7. By detecting the temperature of the reagent itself, the problem of false alarm caused by the instantaneous temperature rise when the refrigerator door is opened is avoided, ensuring that the temperature monitoring is more accurate and reliable. The liquid of the simulated reagent is propylene glycol, and the liquid of the simulated reagent accounts for 80% of the volume of the bottle cavity 3. Propylene glycol is non-toxic, tasteless, and resistant to low temperatures. It can reach a temperature of -40°C without solidification, and can more accurately reflect the temperature of the reagent.

[0042] The temperature sensor 5 is integrally molded with the sealing cover 4 and is located at the center of the sealing cover 4. The temperature sensor 5 does not contact the bottom of the bottle body 1, and the temperature sensor 5 is completely immersed in the liquid of the simulated reagent. The signal transmission line 7 is integrally molded with the sealing cover 4 and extends outside the bottle body 1. The temperature sensor 5 is integrally molded with the sealing cover 4, which improves the tightness of the two, enhances the sealing and stability of the device, and effectively prevents external conditions from interfering with temperature monitoring. The signal transmission line 7 is integrally molded with the sealing cover 4 and extends outside the bottle body 1, reducing the risk of connection problems, improving the safety of the entire device, and providing more flexible external connection options.

[0043] The bottle mouth 2 forms an external thread, and the sealing cover 4 forms an internal thread, and the internal thread cooperates with the external thread. A sealing gasket 6 is provided between the sealing cover 4 and the bottle body 1. The bottle body 1 is made of high borosilicate glass material. The sealing gasket 6 is made of food-grade silicone material. The temperature sensor 5 is a high-precision NTC thermal resistor that is integrally molded and injection-molded with TPE material. The sealing cover 4 is made of reinforced nylon material by injection molding. A sealing gasket 6 is provided between the sealing cover 4 and the bottle body 1, and the sealing gasket 6 is made of food-grade silicone material, so that a tighter closed structure is formed between the sealing cover 4 and the bottle body 1, effectively preventing the entry of external air, moisture or dust and other substances, and improving the sealing of the entire device. The temperature sensor 5 is a high-precision NTC thermal resistor that is integrally molded and injection-molded with TPE material, and the sealing cover 4 is made of reinforced nylon material by injection molding, which ensures the stability and durability of the device.

[0044] like Figure 4-5As shown, the temperature sensor 5 detects the temperature of the simulated reagent. The temperature sensor is completely immersed in the simulated reagent in the bottle body 1, that is, it can normally detect the actual temperature value of the simulated liquid. The temperature sensor 5 in the utility model is located at the central axis of the bottle body 1, and is at a certain distance from the bottom of the bottle body 1, so that it will not touch the bottle wall and the bottom of the bottle, ensuring that the temperature sensor 5 is completely immersed in the simulated reagent. After testing, the temperature sensor 5 can be completely immersed in the simulated reagent in an upright state or a horizontal state.

[0045] When the refrigerator or freezer door is opened, the order of temperature changes is as follows: first, the internal environment temperature of the refrigerator or freezer changes; then, the reagent packaging environment temperature changes; finally, the reagent temperature changes from the outside to the inside. In this preferred embodiment, the temperature sensor 5 is arranged in the liquid of the simulated reagent, and the reagent is simulated by the liquid of the simulated reagent, and the liquid temperature of the simulated reagent is directly detected, thereby actually reflecting the actual temperature of the detected reagent, avoiding the false alarm caused by the instantaneous temperature rise of the refrigerator or freezer door opening, and eliminating the possible missed alarm problem caused by the technical time delay adopted by the prior art to solve the false alarm. This preferred embodiment also has the advantages of high detection accuracy, easy use, low manufacturing cost, safety and environmental protection.

[0046] During the operation of this preferred embodiment, it is necessary to load the simulation reagent into the bottle cavity 3 of the bottle body 1, and seal the bottle mouth with the sealing cover 4 to ensure that the reagent is isolated from the external environment. This preferred embodiment is placed directly in a refrigerator or freezer. The temperature sensor 5 measures the temperature of the simulation reagent by contacting the simulation reagent, and transmits the temperature data to the monitoring system through the signal transmission line 7. Since the temperature of the simulation reagent itself is monitored, it is not affected by changes in the external environment, thus avoiding the occurrence of false alarm problems. The integrally-injected temperature sensor 5 and the sealing cover 4 design improve the sealing and stability of the device and reduce the connection problems between components. The signal transmission line 7 is integrally-injected and extends outside the bottle body, providing more flexible external connection options, making the device easy to integrate into different monitoring systems or data acquisition equipment.

[0047] The temperature sensor 5 is connected to the main control circuit of the acquisition instrument through the signal transmission line 7. When collecting temperature signals, power is supplied to the signal transmission line 7. After the temperature sensor 7 is powered on, it starts to collect the resistance value of the thermistor corresponding to the real-time temperature of the simulated reagent. After the temperature resistance signal is collected, it is returned to the MCU (microcontroller unit), and then the power is interrupted to repeatedly collect temperature signals.

[0048] The above-mentioned implementation mode is merely an explanation of the present invention, and it is not a limitation of the present invention. After reading this specification, those skilled in the art can make non-creative modifications to the present implementation mode as needed, but as long as it is within the scope of the claims of the present invention, it is protected by the patent law.

Claims

1. A temperature detection device for simulating the temperature of a reagent, characterized in that: The device comprises a bottle body (1) for simulating a reagent packaging environment, a bottle cavity (3) of the bottle body (1) containing a liquid of the simulating reagent, a bottle mouth (2) of the bottle body (1) being sealed by a sealing cover (4), the sealing cover (4) being connected to a temperature sensor (5), the temperature sensor (5) being in contact with the liquid of the simulating reagent, and the temperature sensor (5) being connected to a signal transmission line (7); The temperature sensor (5) and the sealing cover (4) are injection molded into one piece; The temperature sensor (5) is located at the central axis of the bottle body (1); The signal transmission line (7) is integrally molded with the sealing cover (4) by injection molding and extends outside the bottle body (1).

2. The temperature detection device for simulating the temperature of a reagent according to claim 1, characterized in that: The temperature sensor (5) is located at the center of the sealing cover (4), and the temperature sensor (5) does not contact the bottom of the bottle body (1).

3. The temperature detection device for simulating the temperature of a reagent according to any one of claims 1 to 2, characterized in that: A sealing gasket (6) is provided between the sealing cover (4) and the bottle body (1).

4. The temperature detection device for simulating the temperature of a reagent according to claim 3, characterized in that: The sealing cover (4) is formed with an internal thread, and the bottle mouth (2) is formed with an external thread, and the internal thread matches the external thread.

5. The temperature detection device for simulating the temperature of a reagent according to claim 3, characterized in that: The sealing gasket (6) is made of food-grade silicone material.

6. The temperature detection device for simulating the temperature of a reagent according to any one of claims 1 to 2, characterized in that: The temperature sensor (5) is a high-precision NTC thermal resistor that is integrally formed and injection-molded with TPE material.

7. The temperature detection device for simulating the temperature of a reagent according to claim 4, characterized in that: The sealing cover (4) is made of reinforced nylon material by injection molding.

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