Reduced pressure distillation device for synthesis of medical intermediates

Abstract

The utility model discloses a reduced pressure distillation device for synthesis of medical intermediates, and relates to the technical field of reduced pressure distillation. The device comprises a distillation barrel and a supporting bottom plate, a stirring mechanism and a distillation mechanism are arranged on the distillation barrel, and the stirring mechanism comprises a driving assembly, a stirring assembly and a cleaning assembly; the driving assembly comprises a motor fixedly mounted on the top surface of the distillation barrel, a rotating rod is fixedly mounted at the output end of the motor, a rotating disc is fixedly mounted on the rotating rod, two sliding rods are fixedly mounted on the rotating disc, an external thread sleeve is fixedly mounted on the inner top wall of the distillation barrel, an internal thread block is in threaded connection with the external thread sleeve, and the internal thread block is in threaded connection with the distillation barrel. The two sliding rods penetrate through the internal thread block, and the internal thread block is slidably connected with the sliding rods. The stirring mechanism is arranged, the stirring rod can move up and down during rotation, medicine raw materials are fully stirred and mixed, it is guaranteed that effective components in the raw materials can be evenly released, and therefore the extraction efficiency is improved.

Description

Technical Field

[0001] The utility model belongs to the technical field of vacuum distillation, in particular to a vacuum distillation device for synthesizing pharmaceutical intermediates. Background Art

[0002] In the prior art, after searching, it was found that a Chinese patent disclosed "A vacuum distillation device for the synthesis of pharmaceutical intermediates", and its application number is "CN202021603010.1". This patent mainly solves the problem that the distillation tank of the current vacuum distillation device needs to be completely sealed through the designed sealing ball, maintaining the high temperature and high pressure environment inside the distillation tank, and ensuring the distillation efficiency of the distillation tank.

[0003] However, before distilling the pharmaceutical intermediates, different types of raw materials need to be fully mixed and stirred to achieve a uniform mixing effect. Only when the raw materials are evenly mixed can the proportions of each component remain consistent, which has a very important impact on the subsequent distillation process and product quality of the pharmaceutical intermediates. However, in the existing mechanism, the stirring rod cannot move up and down during the stirring process, and the materials inside the entire distillation tank cannot be fully mixed, which greatly affects the quality of subsequent distillation. Utility Model Content

[0004] The utility model aims to provide a vacuum distillation device for synthesizing pharmaceutical intermediates. By providing a stirring mechanism, a stirring rod can move up and down when rotating, so as to fully stir and mix the pharmaceutical raw materials, thereby ensuring that in the subsequent heating and distillation process, the effective ingredients in the raw materials can be evenly released, thereby improving the extraction efficiency, and solving the problem that the existing mechanism cannot fully mix the materials inside the entire distillation tank during the stirring process, which greatly affects the quality of the subsequent distillation.

[0005] In order to solve the above technical problems, the utility model is realized by the following technical solutions:

[0006] The utility model discloses a vacuum distillation device for synthesizing pharmaceutical intermediates, comprising a distillation barrel and a supporting bottom plate, wherein a stirring mechanism and a distillation mechanism are arranged on the distillation barrel, and the stirring mechanism comprises a driving component, a stirring component and a cleaning component;

[0007] The driving assembly includes a motor fixedly mounted on the top surface of the distillation barrel, a rotating rod fixedly mounted on the output end of the motor, a turntable fixedly mounted on the rotating rod, two sliding rods fixedly mounted on the turntable, an externally threaded sleeve fixedly mounted on the inner top wall of the distillation barrel, the rotating rod is slidably connected to the inner wall of the externally threaded sleeve, an internally threaded block is threadedly connected to the externally threaded sleeve, both sliding rods penetrate the internally threaded block, and the internally threaded block is slidably connected to the sliding rod.

[0008] Furthermore, the stirring assembly includes a plurality of stirring rods rotatably mounted on the internal thread block, each of the stirring rods is fixedly mounted with a rotating blade, and an arc-shaped scraper is fixedly mounted at the bottom end of the rotating rod, and the arc-shaped scraper is in contact with the inner wall of the distillation barrel.

[0009] Furthermore, the cleaning assembly comprises a cleaning brush fixedly mounted on an end of the stirring rod away from the internal thread block, and the cleaning brush is in contact with the inner wall of the distillation barrel.

[0010] Furthermore, the distillation mechanism includes a support assembly, a condensation assembly and a discharge assembly, the support assembly includes a heater fixedly mounted on the top surface of the support bottom plate, a heating jacket is provided inside the heater, and the inner wall of the heating jacket is fixedly connected to the outer wall of the distillation barrel.

[0011] Furthermore, the condensation component includes a feed port fixedly mounted on the distillation barrel, a vacuum pump fixedly mounted on the top surface of the distillation barrel, a condenser fixedly mounted on the top surface of the distillation barrel, a fixing rod fixedly mounted on the top surface of the supporting bottom plate, a lower hopper fixedly mounted on one end of the fixing rod away from the supporting bottom plate, and the end of the fixing rod away from the supporting bottom plate is fixedly connected to the top surface of the lower hopper.

[0012] Furthermore, the discharge assembly comprises a discharge pipe fixedly mounted on the bottom surface of the lower hopper, and an electromagnetic valve is provided on the discharge pipe.

[0013] The utility model has the following beneficial effects:

[0014] 1. By providing a stirring mechanism, the turntable, the sliding rod and the external threaded sleeve cooperate with each other, so that when the motor drives the rotating rod to rotate slowly, it can drive the external threaded sleeve to rotate. At the same time, the external threaded sleeve and the internal threaded block cooperate with each other. When the internal threaded block rotates, the internal threaded block can move up and down on the external threaded sleeve. Before the distillation barrel is heated and distilled, the pharmaceutical raw materials can be fully stirred and mixed, thereby ensuring that in the subsequent heating and distillation process, the effective ingredients in the raw materials can be evenly released, thereby improving the extraction efficiency.

[0015] 2. By providing a stirring assembly, the stirring rod and the rotating blade cooperate with each other. When the internal thread block rotates to stir the raw materials, the stirring rod and the rotating blade are fully in contact with the raw materials, so that the rotating blade can rotate within a certain range, further improving the mixing efficiency.

[0016] Of course, any product implementing the present invention does not necessarily need to achieve all of the advantages described above at the same time. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the technical solutions of the embodiments of the utility model, the drawings required for describing the embodiments are briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0018] Figure 1 This is a schematic diagram of the overall structure of a vacuum distillation device for synthesizing pharmaceutical intermediates according to the utility model;

[0019] Figure 2 This is a front cross-sectional structural schematic diagram of a vacuum distillation device for synthesizing pharmaceutical intermediates of the utility model;

[0020] Figure 3 This is a schematic structural diagram of a stirring mechanism of a vacuum distillation device for synthesizing pharmaceutical intermediates according to the utility model;

[0021] Figure 4 for Figure 2 A schematic diagram of the enlarged structure at A in the middle;

[0022] Figure 5 for Figure 3 Schematic diagram of the enlarged structure at point B in the middle.

[0023] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0024] 1. Distillation barrel; 2. Stirring mechanism; 3. Distillation mechanism; 11. Feed inlet; 21. Motor; 22. Rotating rod; 23. Turntable; 24. Sliding rod; 25. External threaded sleeve; 26. Internal threaded block; 27. Stirring rod; 271. Rotating blade; 272. Cleaning brush; 273. Arc scraper; 31. Support bottom plate; 32. Heater; 33. Heating jacket; 34. Vacuum pump; 35. Condenser; 36. Fixed rod; 37. Lower hopper; 38. Discharge pipe; 39. Solenoid valve. DETAILED DESCRIPTION

[0025] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0026] See also Figure 1-5As shown, the utility model is a vacuum distillation device for synthesizing pharmaceutical intermediates, comprising a distillation barrel 1 and a supporting bottom plate 31, the distillation barrel 1 is provided with a stirring mechanism 2 and a distillation mechanism 3, the stirring mechanism 2 comprises a driving component, a stirring component and a cleaning component;

[0027] The driving assembly includes a motor 21 fixedly mounted on the top surface of the distillation barrel 1, a rotating rod 22 fixedly mounted on the output end of the motor 21, a turntable 23 fixedly mounted on the rotating rod 22, two sliding rods 24 fixedly mounted on the turntable 23, an externally threaded sleeve 25 fixedly mounted on the inner top wall of the distillation barrel 1, the rotating rod 22 is slidably connected to the inner wall of the externally threaded sleeve 25, an internally threaded block 26 is threadedly connected to the externally threaded sleeve 25, two sliding rods 24 both penetrate the internally threaded block 26, and the internally threaded block 26 is slidably connected to the sliding rod 24.

[0028] Among them Figure 3 As shown, the stirring assembly includes a plurality of stirring rods 27 rotatably mounted on the internal thread block 26, and a rotating blade 271 is fixedly mounted on each of the stirring rods 27. An arc scraper 273 is fixedly mounted on the bottom end of the rotating rod 22, and the arc scraper 273 contacts the inner wall of the distillation barrel 1.

[0029] By providing a stirring assembly, the stirring rod 27 and the rotating blade 271 cooperate with each other. When the internal thread block 26 rotates to stir the raw materials, the stirring rod 27 and the rotating blade 271 are in full contact with the raw materials, so that the rotating blade 271 can rotate within a certain range, further improving the mixing efficiency.

[0030] Among them Figure 3 As shown, the cleaning assembly includes a cleaning brush 272 fixedly mounted on one end of the stirring rod 27 away from the internal thread block 26 , and the cleaning brush 272 is in contact with the inner wall of the distillation barrel 1 .

[0031] By providing a cleaning component, the cleaning brush 272 cooperates with the stirring rod 27. When the stirring rod 27 rotates, it can drive the cleaning brush 272 to scrub the inner wall of the distillation barrel 1. At the same time, the arc-shaped scraper 273 can scrape off the adhesions on the inner bottom wall of the distillation barrel 1. Various adhesions on the inner wall surface of the distillation barrel 1, such as residual pharmaceutical raw material residues, dirt, etc., can be removed in time and effectively. This ensures that before each distillation process starts, the distillation barrel 1 is kept clean.

[0032] Among them Figure 2 As shown, the distillation mechanism 3 includes a supporting assembly, a condensing assembly and a discharging assembly. The supporting assembly includes a heater 32 fixedly mounted on the top surface of a supporting base plate 31. A heating sleeve 33 is provided inside the heater 32. The inner wall of the heating sleeve 33 is fixedly connected to the outer wall of the distillation barrel 1.

[0033] By providing the distillation mechanism 3 , the heater 32 can heat and distill the raw material inside the distillation barrel 1 .

[0034] Among them Figure 2 As shown, the condensation assembly includes a feed port 11 fixedly installed on the distillation barrel 1, a vacuum pump 34 fixedly installed on the top surface of the distillation barrel 1, a condenser 35 fixedly installed on the top surface of the distillation barrel 1, a fixing rod 36 fixedly installed on the top surface of the supporting bottom plate 31, a lower hopper 37 fixedly installed on the end of the fixing rod 36 away from the supporting bottom plate 31, and the end of the fixing rod 36 away from the supporting bottom plate 31 is fixedly connected to the top surface of the lower hopper 37.

[0035] By providing a condensation component, the vacuum pump 34 can put the interior of the distillation barrel 1 in a negative pressure state, reduce the melting point of the material, and the drug mist generated when the material is distilled will condense into drug liquid when passing through the condenser 35 and flow into the lower hopper 37 for collection.

[0036] Among them Figure 2 As shown, the discharge assembly includes a discharge pipe 38 fixedly mounted on the bottom surface of the lower hopper 37 , and an electromagnetic valve 39 is provided on the discharge pipe 38 .

[0037] By providing a discharge assembly, the electromagnetic valve 39 cooperates with the discharge pipe 38 so that the electromagnetic valve 39 can control the discharge speed of the lower hopper 37 and can be adjusted according to actual needs to meet the discharge requirements of different products.

[0038] A specific application of this embodiment is: by providing a stirring mechanism 2, the turntable 23, the slide bar 24 and the external threaded sleeve 25 cooperate with each other, so that when the motor 21 drives the turn bar 22 to rotate slowly, it can drive the external threaded sleeve 25 to rotate, and at the same time, the external threaded sleeve 25 and the internal threaded block 26 cooperate with each other. When the internal threaded block 26 rotates, the internal threaded block 26 can move up and down on the external threaded sleeve 25. Before the distillation barrel 1 is heated and distilled, the pharmaceutical raw materials can be fully stirred and mixed, so as to ensure that in the subsequent heating and distillation process, the effective ingredients in the raw materials can be evenly released, thereby improving the extraction efficiency;

[0039] By providing a stirring assembly, the stirring rod 27 and the rotating blade 271 cooperate with each other, and when the internal thread block 26 rotates to stir the raw materials, the stirring rod 27 and the rotating blade 271 are fully in contact with the raw materials, so that the rotating blade 271 can rotate within a certain range, further improving the mixing efficiency;

[0040] By providing a cleaning component, the cleaning brush 272 cooperates with the stirring rod 27. When the stirring rod 27 rotates, the cleaning brush 272 can be driven to scrub the inner wall of the distillation barrel 1, so that various adhesions on the inner wall surface of the distillation barrel (1), such as residual pharmaceutical raw material residues, dirt, etc., can be removed in a timely and effective manner. In this way, it can be ensured that before each distillation process starts, the distillation barrel (1) is kept clean.

[0041] By providing the distillation mechanism 3, the heater 32 can heat and distill the raw materials inside the distillation barrel 1;

[0042] By providing a condensation assembly, the vacuum pump 34 can make the interior of the distillation barrel 1 in a negative pressure state, reduce the melting point of the material, and the drug mist generated during the distillation of the material will condense into drug liquid when passing through the condensation pipe 35, and flow into the lower hopper 37 for collection;

[0043] By providing a discharge assembly, the electromagnetic valve 39 cooperates with the discharge pipe 38 so that the electromagnetic valve 39 can control the discharge speed of the lower hopper 37 and can be adjusted according to actual needs to meet the discharge requirements of different products.

[0044] In the description of this specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the utility model. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0045] The preferred embodiments of the utility model disclosed above are only used to help explain the utility model. The preferred embodiments do not describe all the details in detail, nor do they limit the utility model to the specific implementation methods described. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the utility model, so that technicians in the relevant technical field can well understand and use the utility model. The utility model is limited only by the claims and their full scope and equivalents.

Claims

1. A vacuum distillation apparatus for synthesizing pharmaceutical intermediates, comprising a distillation barrel (1) and a supporting bottom plate (31), characterized in that: The distillation barrel (1) is provided with a stirring mechanism (2) and a distillation mechanism (3), wherein the stirring mechanism (2) comprises a driving component, a stirring component and a cleaning component; The driving assembly includes a motor (21) fixedly mounted on the top surface of the distillation barrel (1), a rotating rod (22) fixedly mounted on the output end of the motor (21), a turntable (23) fixedly mounted on the rotating rod (22), two sliding rods (24) fixedly mounted on the turntable (23), an externally threaded sleeve (25) fixedly mounted on the inner top wall of the distillation barrel (1), the rotating rod (22) is slidably connected to the inner wall of the externally threaded sleeve (25), an internally threaded block (26) is threadedly connected to the externally threaded sleeve (25), the two sliding rods (24) both penetrate the internally threaded block (26), and the internally threaded block (26) is slidably connected to the sliding rod (24).

2. A vacuum distillation apparatus for synthesizing a pharmaceutical intermediate according to claim 1, characterized in that: The stirring assembly includes a plurality of stirring rods (27) rotatably mounted on an internal thread block (26), each of the stirring rods (27) being fixedly mounted with a rotating blade (271), and an arc-shaped scraper (273) being fixedly mounted at the bottom end of the rotating rod (22), and the arc-shaped scraper (273) is in contact with the inner wall of the distillation barrel (1).

3. A vacuum distillation apparatus for synthesizing a pharmaceutical intermediate according to claim 2, characterized in that: The cleaning assembly comprises a cleaning brush (272) fixedly mounted on one end of the stirring rod (27) away from the internal thread block (26), and the cleaning brush (272) is in contact with the inner wall of the distillation barrel (1).

4. A vacuum distillation apparatus for synthesizing a pharmaceutical intermediate according to claim 1, characterized in that: The distillation mechanism (3) includes a support assembly, a condensation assembly and a discharge assembly. The support assembly includes a heater (32) fixedly mounted on the top surface of a support base plate (31). A heating jacket (33) is provided inside the heater (32). The inner wall of the heating jacket (33) is fixedly connected to the outer wall of the distillation barrel (1).

5. A vacuum distillation apparatus for synthesizing a pharmaceutical intermediate according to claim 4, characterized in that: The condensation component comprises a feed port (11) fixedly mounted on the distillation barrel (1), a vacuum pump (34) fixedly mounted on the top surface of the distillation barrel (1), and a condenser (35) fixedly mounted on the top surface of the distillation barrel (1).

6. A vacuum distillation apparatus for synthesizing pharmaceutical intermediates according to claim 5, characterized in that: A fixing rod (36) is fixedly mounted on the top surface of the supporting bottom plate (31), a lower hopper (37) is fixedly mounted on one end of the fixing rod (36) away from the supporting bottom plate (31), and the end of the fixing rod (36) away from the supporting bottom plate (31) is fixedly connected to the top surface of the lower hopper (37).

7. A vacuum distillation apparatus for synthesizing a pharmaceutical intermediate according to claim 6, characterized in that: The discharge assembly comprises a discharge pipe (38) fixedly mounted on the bottom surface of the lower hopper (37), and an electromagnetic valve (39) is arranged on the discharge pipe (38).

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