Cell imaging equipment

Abstract

The utility model provides cell imaging equipment. The cell imaging equipment comprises a clamping assembly, an imaging acquisition assembly, a focusing assembly and a shell provided with an accommodating space, the clamping assembly, the imaging acquisition assembly and the focusing assembly are all mounted on the shell; the clamping assembly is used for installing a to-be-tested sample in the accommodating space; the image acquisition assembly is arranged opposite to the to-be-detected sample and is used for shooting a cell image in the to-be-detected sample; the focusing assembly and the imaging collection assembly are both located in the containing space, and the focusing assembly is connected with the imaging collection assembly and used for driving the imaging collection assembly to move so as to adjust the distance between the imaging collection assembly and a to-be-detected sample. The cell imaging device is simple in structure, small in size and easy and convenient to operate, and the clamping assembly stably installs a sample to be detected in the containing space, so that the stability and the accuracy of shot cell imaging are guaranteed.

Description

Technical Field

[0001] The utility model belongs to the field of biomedicine, and particularly relates to a cell imaging device. Background Art

[0002] At present, cell imaging counting is an important technology in the biomedical field, cytological research and clinical diagnosis. In the related technologies, cell counting methods rely on manual operation, manual counting under a microscope or flow cytometry to achieve cell imaging counting, but manual operation and manual counting under a microscope are time-consuming and labor-intensive, and the counting results are subjective and erroneous; and flow cytometers are often miniaturized and integrated with a large mechanical structure and a complex optical system, which requires high professional knowledge of the operator, is large in size, is not conducive to use in places far away from the laboratory, and is expensive. Utility Model Content

[0003] The utility model provides a cell imaging device to solve the technical problems of complex operation and large volume in the prior art.

[0004] In view of the above technical problems, an embodiment of the utility model provides a cell imaging device, comprising a clamping component, an imaging acquisition component, a focusing component and a shell provided with a accommodating space; the clamping component, the imaging acquisition component and the focusing component are all installed on the shell; the clamping component is used to install the sample to be tested in the accommodating space; the imaging acquisition component is arranged opposite to the sample to be tested and is used to capture cell imaging in the sample to be tested; the focusing component and the imaging acquisition component are both located in the accommodating space, the focusing component is connected to the imaging acquisition component and is used to drive the imaging acquisition component to move so as to adjust the distance between the imaging acquisition component and the sample to be tested.

[0005] Optionally, the cell imaging device further comprises a light source assembly, and the light source assembly and the imaging acquisition assembly are respectively arranged on opposite sides of the clamping assembly, so that an installation space for installing a sample to be tested is formed between the light source assembly and the imaging acquisition assembly.

[0006] Optionally, a carrying platform for placing the sample to be tested is provided on the housing, and the clamping assembly includes at least one clamping member arranged on the carrying platform and used to press the sample to be tested onto the carrying platform.

[0007] Optionally, the supporting platform includes a supporting body provided with a threaded hole, the clamping member includes a clamping jaw, a clamping screw and a clamping spring, the clamping jaw is provided with a through hole, and the clamping spring is sleeved on the clamping screw; one end of the clamping screw is provided with a screw head, and the other end of the clamping screw passes through the through hole and the threaded hole and is threadedly connected to the threaded hole; one end of the compression spring abuts against the screw head, and the other end of the compression spring abuts against the edge of the through hole on the clamping jaw.

[0008] Optionally, a positioning hole connected to the through hole is further provided on the clamping jaw, the positioning hole is coaxially arranged with the through hole, and the radius of the positioning hole is larger than the radius of the through hole; one end of the clamping spring away from the screw head abuts against the bottom surface of the positioning hole.

[0009] Optionally, the light source assembly includes a light source circuit board, a light source arranged on the light source circuit board, and a light shielding plate arranged relative to the light source circuit board; the light source is located between the light source circuit board and the light shielding plate; the installation space is formed between the light shielding plate and the imaging acquisition assembly, and a light-transmitting hole is provided on the light shielding plate at a position opposite to the light source, and the light-transmitting hole is used to transmit the light of the light source to illuminate the sample to be tested located in the installation space.

[0010] Optionally, the carrying platform is provided with a mounting cavity and a mounting groove communicating with the mounting cavity; the light source circuit board, the light source and the light shielding plate are all installed in the mounting cavity; the carrying platform further comprises a side panel installed in the mounting groove and having a wire passing hole;

[0011] The clamping assembly comprises two clamping members which are installed at intervals on the side panels and are used to press the sample to be tested onto the light shielding plate. The two clamping members are respectively arranged on opposite sides of the light source.

[0012] Optionally, the shell is further provided with a top opening and a rear opening; the cell imaging device further comprises a top cover detachably connected to the top opening, and a rear cover detachably connected to the rear opening, and the top cover, the rear cover and the shell enclose the accommodation space;

[0013] At least one wire outlet hole is provided on the rear cover.

[0014] Optionally, the housing is further provided with a limiting hole; the focusing assembly comprises a mounting plate provided with a threaded focusing hole, a focusing screw passing through the limiting hole and threadedly connected to the threaded focusing hole, and a compression spring sleeved on the focusing screw; the imaging acquisition assembly is fixedly mounted on the mounting plate; one end of the compression spring abuts against an end of the mounting plate away from the imaging acquisition assembly, and the other end of the compression spring abuts against an edge of the limiting hole;

[0015] When the focusing screw rotates in the limiting hole, the mounting plate and the imaging acquisition assembly mounted on the mounting plate are driven to move up and down.

[0016] Optionally, the shell is further provided with a guide space connected to the accommodating space, the focusing assembly and the imaging acquisition assembly are both located in the accommodating space, the mounting plate is provided with a guide hole, the focusing assembly also includes a guide column passing through the guide hole and installed in the guide space; the guide column is arranged parallel to the focusing screw.

[0017] In the utility model, the cell imaging device comprises a clamping component, an imaging acquisition component, a focusing component and a shell provided with a accommodating space; the clamping component, the imaging acquisition component and the focusing component are all mounted on the shell; the clamping component is used to mount the sample to be tested in the accommodating space; the imaging acquisition component is arranged opposite to the sample to be tested and is used to capture cell imaging in the sample to be tested; the focusing component and the imaging acquisition component are both located in the accommodating space, the focusing component is connected to the imaging acquisition component and is used to drive the imaging acquisition component to move so as to adjust the distance between the imaging acquisition component and the sample to be tested.

[0018] In the above-mentioned embodiment of the utility model, the imaging acquisition component is connected to the focusing component as an integral body and installed in the housing space of the shell, the clamping component firmly installs the sample to be tested in the housing space for the imaging acquisition component to shoot cell imaging, and the focusing component can drive the imaging acquisition component to move relative to the clamping component to adjust the distance between the imaging acquisition component and the sample to be tested, thereby realizing the focusing function of the imaging acquisition component. In the utility model, the imaging acquisition component can be used to shoot cell imaging and complete cell counting according to cell imaging, and the compact arrangement of the focusing component, the imaging acquisition component and the light source component greatly reduces the volume of the cell imaging adjustment device. Since the cell imaging adjustment device has a small volume and a simple structure, the manufacturing cost is low; and the imaging acquisition component is fixedly connected to the focusing component, and the clamping component firmly installs the sample to be tested in the housing space to ensure the stability and accuracy of the captured cell imaging. Only the focusing component needs to be operated to synchronously drive the imaging acquisition component away from or close to the sample to be tested, and the focusing operation during cell imaging counting is completed as needed, which is simple and convenient to operate. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] The utility model is further described below in conjunction with the accompanying drawings and embodiments.

[0020] Figure 1 It is a schematic diagram of the structure of a cell imaging device provided in one embodiment of the utility model.

[0021] Figure 2 It is a structural schematic diagram of a clamping member and a supporting platform of a cell imaging device provided in one embodiment of the utility model.

[0022] Figure 3 It is a structural schematic diagram of a light source assembly of a cell imaging device provided in one embodiment of the utility model.

[0023] Figure 4 It is a schematic diagram of the installation structure of the side panel of the cell imaging device provided by another embodiment of the utility model.

[0024] Figure 5 It is a structural schematic diagram of a shell of a cell imaging device provided by another embodiment of the utility model.

[0025] Figure 6 This is a schematic diagram of the three-dimensional structure of a cell imaging device provided by an embodiment of the utility model.

[0026] The reference numerals in the specification are as follows:

[0027] 1-focusing assembly, 110-mounting plate, 1110-guide hole, 120-threaded focusing hole, 130-focusing screw, 140-compression spring, 150-guide column, 2-imaging acquisition assembly, 210-camera body, 220-lens, 230-camera circuit board, 240-camera wiring terminal, 3-light source assembly, 310-light source circuit board, 320-light source, 330-shading plate, 3310-light transmission hole, 340-light source wiring terminal, 350 -connecting screw, 4-installation space, 5-housing, 510-limiting hole, 520-accommodating space, 530-guide space, 540-top cover, 550-back cover, 5510-wire outlet hole, 6-clamping assembly, 610-clamping claw, 6110-through hole, 620-pressing screw, 630-pressing spring, 7-carrying platform, 710-carrying body, 720-installation cavity, 730-installation groove, 740-side panel, 7410-wire hole, 8-sample to be tested. DETAILED DESCRIPTION

[0028] In order to make the technical problems, technical solutions and beneficial effects solved by the utility model more clear, the utility model is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the utility model and are not used to limit the utility model.

[0029] It should be understood that the directions or positional relationships indicated by terms such as "upper", "lower", "left", "right", "front", "back", and "middle" are based on the directions or positional relationships shown in the accompanying drawings and are only used to facilitate the description of the present invention and simplify the description. They do not indicate or imply that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore should not be understood as a limitation of the present invention.

[0030] In the present invention, in order to better illustrate the structure of the cell imaging device and its connection relationship, the "upper" referred to in the present invention is Figure 1 The cell imaging device shown in FIG. 1 is above the cell imaging device shown in FIG. 1 ; the “below” referred to in the present invention is Figure 1 ) shown below the cell imaging device.

[0031] like Figures 1 to 6 As shown, an embodiment of the utility model provides a cell imaging device, including a clamping component 6, an imaging acquisition component 2, a focusing component 1 and a shell 5 with a storage space 520; the clamping component 6, the imaging acquisition component 2 and the focusing component 1 are all installed on the shell 5; the clamping component 6 is used to install the sample 8 to be tested in the storage space 520; the imaging acquisition component 2 is arranged opposite to the sample 8 to be tested and is used to take cell images in the sample 8 to be tested; the focusing component 1 and the imaging acquisition component 2 are both located in the storage space 520, and the focusing component 1 is connected to the imaging acquisition component 2 and is used to drive the imaging acquisition component 2 to move so as to adjust the distance between the imaging acquisition component 2 and the sample 8 to be tested. Figure 1 As shown, the focusing component 1, the imaging acquisition component 2 and the clamping component 6 are sequentially installed in the accommodating space 520 of the housing 5, the clamping component 6 clamps the sample 8 to be tested and installs it in the accommodating space 520, and the imaging acquisition component 2 is suspended directly above the sample 8 to be tested, and the imaging acquisition component 2 can be used to shoot cell imaging and complete cell counting based on the cell imaging. By combining advanced imaging technology and image processing algorithms, a high-precision, high-speed, simple and easy-to-use cell counting function is achieved, which can complete the imaging and counting tasks of large-scale cells in a short time, meet high-throughput requirements, help improve the accuracy and efficiency of cytological research, and provide a scientific basis for clinical diagnosis. And the imaging acquisition component 2 can be a camera component, for example, the imaging acquisition component 2 can be a miniature camera, etc., and the distance between the imaging acquisition component 2 and the sample 8 to be tested is adjusted by the focusing component 1. The above-mentioned cell imaging adjustment device of the utility model has a simple and compact structure, which reduces the volume of the cell imaging adjustment device and reduces the manufacturing cost.

[0032] In the above-mentioned embodiment of the utility model, the focusing component 1, the imaging acquisition component 2 and the clamping component 6 are compactly arranged in sequence from top to bottom in the cell imaging device. The imaging acquisition component 2 is connected to the focusing component 1 as a whole and installed in the accommodating space 520 of the shell 5. The clamping component 6 firmly installs the sample 8 to be tested in the accommodating space 520 and is located below the imaging acquisition component 2, so that the imaging acquisition component 2 can take cell images of the sample 8 to be tested. The focusing component 1 can drive the imaging acquisition component 2 to move relative to the clamping component 6 to adjust the distance between the imaging acquisition component 2 and the sample 8 to be tested, thereby realizing the focusing function of the imaging acquisition component 2, so as to complete the imaging acquisition component 2 to take cell images in the sample 8 to be tested according to real-time needs. In the present invention, the imaging acquisition component 2 can be used to capture cell images and complete cell counting based on the cell images. By combining advanced imaging technology and image processing algorithms, a high-precision, high-speed, easy-to-use cell counting function is achieved, and large-scale cell imaging and counting tasks can be completed in a short time, meeting high-throughput requirements, helping to improve the accuracy and efficiency of cytological research, and providing a scientific basis for clinical diagnosis; and the compact arrangement of the focusing component 1, the imaging acquisition component 2, and the light source component 6 greatly reduces the volume of the cell imaging adjustment device. Due to the small volume and simple structure of the cell imaging adjustment device, the manufacturing cost is low; and the imaging acquisition component 2 is fixedly connected to the focusing component 1, and the clamping component 6 firmly installs the sample 8 to be tested in the accommodating space 520 to ensure the stability and accuracy of the cell imaging captured by the imaging acquisition component 2. Only the focusing component 1 needs to be operated to synchronously drive the imaging acquisition component 2 away from or close to the sample 8 to be tested, and the focusing operation during cell imaging counting is completed as needed, which is simple and convenient to operate.

[0033] In one embodiment, if Figure 1 and Figure 3 As shown, the cell imaging device further includes a light source assembly 3, and the light source assembly 3 and the imaging acquisition assembly 2 are respectively arranged on opposite sides of the clamping assembly 6, so that an installation space 4 for installing the sample 8 to be tested is formed between the light source assembly 3 and the imaging acquisition assembly 2. It can be understood that the light source assembly 3 is arranged below the clamping assembly 6 (i.e. Figure 1 The imaging collection component 2 is arranged above the clamping component 6 (i.e. Figure 1), the installation space 4 formed between the light source assembly 3 and the imaging acquisition assembly 2 is used to install the sample 8 to be tested, and the sample 8 to be tested is fixedly installed in the installation space 4 by the clamping assembly 6. The sample 8 to be tested can always remain stable during the cell imaging process to ensure the accuracy of the shooting. In this embodiment, the light source assembly 3 can be a micro light source, and the above-mentioned micro camera (imaging acquisition assembly 2) is integrated with the micro light source structure, which further reduces the volume of the cell imaging adjustment device and reduces the manufacturing cost.

[0034] In one embodiment, if Figures 2 to 3 As shown, the housing 5 is provided with a carrier 7 for placing a sample 8 to be tested, and the clamping assembly 6 includes at least one clamping member arranged on the carrier 7 and used to press the sample 8 to be tested onto the carrier 7. It can be understood that in order to maintain the stability of the installation of the sample 8 to be tested, the clamping member of the clamping assembly 6 presses the sample 8 to be tested onto the carrier 7. In the present utility model, the number of clamping members can also be set to one or more according to requirements.

[0035] In one embodiment, if Figures 2 to 3As shown, the supporting platform 7 includes a supporting body 710 provided with a threaded hole, and the clamping member includes a clamping jaw 610, a clamping screw 620 and a clamping spring 630. The clamping jaw 610 is provided with a through hole 6110, and the clamping spring 630 is sleeved on the clamping screw 620; one end of the clamping screw 620 is provided with a screw head, and the other end of the clamping screw 620 passes through the through hole 6110 and the threaded hole and is threadedly connected to the threaded hole; one end of the clamping spring 630 abuts against the screw head, and the other end of the clamping spring 630 abuts against the edge of the through hole 6110 on the clamping jaw 610. It can be understood that the clamping member is mounted on the carrier body 710. Specifically, a threaded hole is provided on the carrier body 710, a through hole 6110 is provided on the clamping jaw 610 of the clamping member, a screw head is provided at one end of the clamping screw 620 of the clamping member, and the other end of the clamping screw 620 passes through the through hole 6110 and the clamping spring 630 and is threadedly connected to the threaded hole. It can be understood that when the clamping screw 620 is screwed so that the clamping jaw 610 moves along the clamping screw 620 and approaches the sample 8 to be tested on the carrier 7, the clamping jaw 610 is pressed against the sample to be tested by the pressure of the clamping spring 630 sleeved on the clamping screw 620. When the clamping screw 620 is screwed in the opposite direction, so that the clamping jaw 610 moves along the clamping screw 620 and moves away from the sample 8 to be tested on the carrier 7, the pressure of the clamping spring 630 sleeved on the clamping screw 620 will gradually decrease. At this time, the pressure of the clamping jaw 610 on the sample 8 to be tested decreases. At this time, the clamping screw 620 is continuously screwed. When the clamping spring 630 is no longer compressed, the pressure of the clamping jaw 610 on the sample 8 to be tested decreases to close to 0, that is, the sample 8 to be tested is released by the clamping jaw 610. At this time, the sample 8 to be tested can be taken out. The above-mentioned setting of the clamping member in this embodiment makes the installation of the sample 8 to be tested on the carrier 7 simpler and more convenient.

[0036] In one embodiment, if Figure 2 As shown, the clamp 610 is also provided with a positioning hole connected to the through hole 6110, the positioning hole is coaxially arranged with the through hole 6110, and the radius of the positioning hole is larger than the radius of the through hole 6110; the end of the spring away from the screw head abuts against the bottom surface of the positioning hole. It can be understood that the radius of the positioning hole is larger than the radius of the through hole 6110, and the positioning hole and the through hole 6110 are coaxially arranged to form a stepped hole, the positioning hole is located above the through hole 6110, and the end of the clamping spring 630 away from the clamping screw head is in contact with the bottom surface of the positioning hole (that is, the stepped connecting surface of the stepped hole formed by the positioning hole and the through hole 6110), and the positioning hole is used to position the clamping spring 630; the through hole 6110 is adapted to the clamping screw 620, and the clamping jaw 610 is slidably connected to the clamping screw 620 through the through hole 6110, thereby realizing the up and down movement of the clamping jaw 610 along the clamping screw 620, and finally realizing the clamping or relaxation of the clamping jaw 610 on the sample to be tested.

[0037] In one embodiment, if Figure 3 As shown, the light source assembly 3 includes a light source circuit board 310, a light source 320 arranged on the light source circuit board 310, and a light shielding plate 330 arranged relative to the light source circuit board 310; the light source 320 is located between the light source circuit board 310 and the light shielding plate 330; the installation space 4 is formed between the light shielding plate 330 and the imaging acquisition assembly 2, and a light-transmitting hole 3310 is provided on the light shielding plate 330 at a position opposite to the light source 320, and the light-transmitting hole 3310 is used to transmit the light of the light source 320 to illuminate the sample 8 to be tested located in the installation space 4. It can be understood that the light source 320 of the light source assembly 3 is installed on the light source circuit board 310 and is located between the light source circuit board 310 and the shading plate 330. The shading plate 330 is provided with a light-transmitting hole 3310 corresponding to the light source 320. The lens 220 of the imaging acquisition assembly 2 is vertically suspended above the shading plate 330. An installation space 4 for installing the sample 8 to be tested is formed between the shading plate 330 and the lens 220. The light of the light source 320 is transmitted through the light-transmitting hole 3310 to illuminate the sample 8 to be tested located in the installation space 4, so as to provide the lens 220 with the light required for capturing the cell imaging in the sample to be tested, so that the cell imaging is clearer and more visible, thereby improving the cell imaging and counting effects.

[0038] In one embodiment, if Figures 2 to 4 As shown, the carrier 7 is provided with a mounting cavity 720 and a mounting groove 730 connected to the mounting cavity 720; the light source circuit board 310, the light source 320 and the light shielding plate 330 are all mounted in the mounting cavity 720; the carrier 7 also includes a side panel 740 mounted in the mounting groove 730 and having a wire hole 7410; the clamping assembly 6 includes two clamping members installed at intervals on the side panel 740 and used to press the sample 8 to be tested on the light shielding plate 330, and the two clamping members are respectively arranged on opposite sides of the light source 320. It can be understood that the light source circuit board 310, the light source 320 and the light shielding plate 330 are all mounted in the mounting cavity 720, which makes full use of the space of the carrier 7 and reduces the volume of the cell imaging device. A side panel 740 with a wire hole 7410 is provided in the mounting groove 730 of the carrier 7. The side panel 740 can protect the components of the mounting cavity 720 from external impact. The wire hole 7410 is used to lead the wire in the mounting cavity 720 to the outside of the cell imaging device. The clamping assembly 6 includes two clamping members, which are arranged in parallel on the carrier 7 and symmetrically pressed at both ends of the central axis of the sample 8 to be tested, so as to further improve the stability of the sample 8 to be tested during the imaging process.

[0039] Furthermore, if Figure 3As shown, the light source assembly 3 further includes a light source connection terminal 340 mounted on the light source circuit board 310, and the light source connection terminal 340 is located between the light shielding plate 330 and the light source circuit board 310. It can be understood that since a space layer for installing the light source 320 has been set between the light shielding plate 330 and the light source circuit board 310, at this time, the light source connection terminal 340 and the light source 320 are installed in the same space layer. At this time, it is not necessary to set an additional space layer for the light source connection terminal 340 to avoid it from being squeezed, making the structure more compact and reducing the overall volume. The light source connection terminal 340 of the light source assembly 3 can be used to connect a power supply, and the light source connection terminal 340 is installed on the light source circuit board 310 and is located below the light shielding plate 330.

[0040] Furthermore, if Figure 3 As shown, the light source assembly 3 also includes a connecting screw 350, the bottom end of the connecting screw 350 is installed on the bottom surface of the installation cavity 720, and the top end of the connecting screw 350 is connected to the end surface of the light source circuit board 310 away from the shading plate 330; the connecting screw 350, the light source circuit board 310, the light source 320 and the shading plate 330 are all installed in the installation cavity 720. It can be understood that the light source circuit board 310 of the light source assembly 3 is installed in the mounting cavity 720 of the mounting platform through the connecting screw 350, the first end of the connecting screw 350 is connected to the bottom surface of the mounting cavity 720, and the second end of the connecting screw 350 is connected to the end surface of the light source circuit board 310 facing away from the shading plate 330, so that the light source circuit board 310 is suspended in the mounting cavity 720, and a space is formed between the bottom surface of the mounting cavity 720 and the light source circuit board 310 to facilitate the heat dissipation of the light source circuit board 310 (instead of fitting the light source circuit board 310 on the bottom surface of the mounting cavity), so that the light source circuit board 310 can utilize the space to fully dissipate heat and extend its service life.

[0041] In one embodiment, if Figure 5As shown, the housing 5 is also provided with a top opening and a rear opening; the cell imaging device further comprises a top cover 540 detachably connected to the top opening, and a rear cover 550 detachably connected to the rear opening, the top cover 540, the rear cover 550 and the housing 5 enclose the accommodation space 520; at least one outlet hole 5510 is provided on the rear cover 550. It can be understood that the accommodation space 520 for installing the focusing assembly 1, the imaging acquisition assembly 2, the clamping assembly 6 and the light source assembly 3 is enclosed by the top cover 540, the rear cover 550 and the housing 5; the top cover 540 is detachably connected to the top opening, and the rear cover 550 is detachably connected to the rear opening, which facilitates the installation, disassembly and maintenance of the focusing assembly 1, the imaging acquisition assembly 2, the clamping assembly 6 and the light source assembly 3 in the accommodation space 520. The outlet hole 5510 is used to lead the lines in the accommodation space 520 to the outside of the cell imaging device.

[0042] In one embodiment, if Figure 2 and Figure 6 As shown, a limiting hole 510 is also provided on the shell 5; the focusing assembly 1 includes a mounting plate 110 provided with a threaded focusing hole 120, a focusing screw 130 passing through the limiting hole 510 and threadedly connected to the threaded focusing hole 120, and a compression spring 140 sleeved on the focusing screw 130; the imaging acquisition assembly 2 is fixedly mounted on the mounting plate 110; one end of the compression spring 140 abuts against an end of the mounting plate 110 away from the imaging acquisition assembly 2, and the other end of the compression spring 140 abuts against the edge of the limiting hole 510; when the focusing screw 130 rotates in the limiting hole 510, it drives the mounting plate 110 and the imaging acquisition assembly 2 mounted on the mounting plate 110 to move up and down.

[0043] It can be understood that the focusing assembly 1 is composed of a mounting plate 110 provided with a threaded focusing hole 120, a focusing screw 130 and a compression spring 140 sleeved on the focusing screw 130. The focusing screw 130 passes through the limiting hole 510 and the threaded focusing hole 120 on the shell 5 and is connected to the mounting plate 110 to form the focusing assembly 1. The compression spring 140 is sleeved on the focusing screw 130 and is located between one end of the mounting plate 110 facing away from the imaging acquisition assembly 2 and the edge of the limiting hole 510. When it is necessary to perform focusing operation on the imaging acquisition component 2, if the focusing screw 130 is tightened, the mounting plate 110 moves along the focusing screw 130 toward the limiting hole 510, and the imaging acquisition component 2 fixedly connected to the mounting plate 110 is driven away from the light source component 3 (that is, away from the sample to be tested 8 arranged above the light source component 3), so that the distance between the imaging acquisition component 2 and the sample to be tested 8 gradually increases; if the focusing screw 130 is loosened, the mounting plate 110 moves along the focusing screw 130 in the direction away from the limiting hole 510, and the imaging acquisition component 2 fixedly connected to the mounting plate 110 is driven close to the light source component 3 (that is, close to the sample to be tested 8 arranged above the light source component 3), so that the distance between the imaging acquisition component 2 and the sample to be tested 8 gradually decreases, thereby achieving the focusing effect of the imaging acquisition component 2; when performing the focusing operation in the above embodiment, during the up and down movement of the mounting plate 110, the compression spring 140 is always pressed The compression connection is between the end of the mounting plate 110 away from the imaging acquisition component 2 and the edge of the limiting hole 510. When the distance between the mounting plate 110 and the limiting hole 510 is reduced, the compression spring 140 can adjust the moving speed of the imaging acquisition component 2 fixedly connected to the mounting plate 110 to remain stable, avoid excessive jitter of the imaging acquisition component 2 during movement and affect the cell imaging quality, and can also play a certain protective role for the electronic components in the imaging acquisition component 2; and when the distance between the mounting plate 110 and the limiting hole 510 increases, the compression spring 140 can assist in stably pushing the mounting plate 110 downward through its own elastic force (if the compression spring 140 is not present, it is difficult to maintain a precise and stable downward pushing speed of the focusing screw 130 for the mounting plate 110), thereby causing the imaging acquisition component 2 fixedly connected to the mounting plate 110 to move downward at a stable speed. The provision of the compression spring 140 improves the efficiency and accuracy of the focusing operation.

[0044] In one embodiment, if Figure 2 and Figure 6As shown, the housing 5 is further provided with a guide space 530 connected to the accommodation space 520, the focusing assembly 1 and the imaging acquisition assembly 2 are both located in the accommodation space 520, the mounting plate 110 is provided with a guide hole 1110, and the focusing assembly 1 further includes a guide post 150 passing through the guide hole 1110 and installed in the guide space 530; the guide post 150 is arranged in parallel with the focusing screw 130. It can be understood that, as Figure 2 As shown in the embodiment, the shell 5 is provided with two guide spaces 530 located on opposite sides of the accommodating space 520, and the focusing assembly 1 and the imaging acquisition assembly 2 are installed in the accommodating space 520, and the focusing assembly 1 also includes a plurality of guide columns 150, and the plurality of guide columns 150 are respectively installed in the two guide spaces 530; the mounting plate 110 is horizontally arranged in the accommodating space 520, and the opposite ends of the mounting plate 110 extend into the two guide spaces 530 respectively, so that guide holes 1110 are respectively provided at the two end positions of the guide space 530 on the mounting plate 110 and at the positions opposite to the guide columns 150, corresponding to each other. Furthermore, a top opening is provided on the shell 5, and the top opening is detachably connected to the top cover, and the top opening is arranged opposite to the guide space 530 and the accommodating space 520. At this time, the bottom end of the guide column 150 can be directly fixedly installed on the bottom of the guide space 530, and the top end is arranged opposite to the top opening. In this way, the guide column 150 is fixedly installed in the guide space 530, and the mounting plate 110 can be inserted from the top opening, and after the guide hole 1110 is aligned with the guide column 150 and inserted, the mounting plate is installed in the guide space 530 and the accommodating space 520. At this time, the guide hole 1110 is aligned with the guide column 150 for clearance fit, and the mounting plate 110 can move up and down along the guide column 150. Further, the number of guide posts 150 can be set to multiple according to the requirements, for example, it can be 2 or 4 guide posts 150 arranged in parallel, and the multiple guide posts 150 are all arranged in parallel with the focusing screw 130, and the multiple guide posts 150 can also be arranged symmetrically with the focusing screw 130 as the symmetry axis, and the focusing screw 130 can be set at the center of the mounting plate 110. When the focusing component 1 performs a focusing operation on the imaging acquisition component 2, when the focusing screw 130 is turned, the guide post 150 can guide the mounting plate 110 when it moves up or down along the focusing screw 130, and can also make the up and down movement speed of the mounting plate 110 stable, thereby synchronously adjusting the stable adjustment of the distance between the imaging acquisition component 2 and the sample to be measured.

[0045] Furthermore, if Figure 2 and Figure 6As shown, the imaging acquisition component 2 includes a camera body 210, a lens 220 mounted on the camera body 210, and a camera circuit board 230 connected between the camera body 210 and the focusing component 1. The end of the camera body 210 away from the lens 220 is mounted on the camera circuit board 230, and a camera connection terminal 240 is mounted on the end face of the circuit board away from the camera body 210. It can be understood that the camera body 210 is connected to the focusing component 1 through the camera circuit board 230, and the end face of the camera circuit board 230 away from the camera body 210 is fixedly connected to the focusing component 1, so that the distance between the lens 220 and the sample 8 to be tested can be adjusted along with the focusing component 1. The camera connection terminal 240 is mounted on the end face of the camera circuit board 230 away from the camera body 210, and the camera connection terminal 240 is used to connect the camera data line to save and transmit the cell imaging data captured by the imaging acquisition component 2, or to connect the driving power supply.

[0046] In one embodiment, if Figure 1 to Figure 2 As shown, the focusing assembly 1 also includes a connecting rod vertically arranged on the end face of the mounting plate 110 facing the camera body 210, one end of the connecting rod is fixedly connected to the end face of the mounting plate 110 facing the camera body 210, and the other end of the connecting rod is fixedly connected to the end face of the camera circuit board 230 of the connecting member 230 away from the camera body 210. In this way, the connecting rod is connected between the bottom wall of the mounting plate 110 and the camera circuit board 230, and a heat dissipation space is formed between the mounting plate 110 and the camera circuit board 230 to facilitate the heat dissipation of the camera circuit board 230 during operation, and the camera circuit board 240 is just located in the heat dissipation space. The supporting effect of the connecting rod can prevent the mounting plate 110 and the camera circuit board 230 from squeezing the camera circuit board 240. Therefore, the setting of the connecting rod can not only realize the fixed connection between the imaging acquisition assembly 2 and the focusing assembly 1, but also ensure that there is a certain distance between the camera circuit board 230 and the focusing assembly 1 to prevent the camera circuit board 230 and the camera circuit board 240 from being damaged by collision, squeezing, etc. during the focusing process, and it is also convenient for heat dissipation.

[0047] Furthermore, the number of the connecting rods can be set according to demand, for example, four connecting rods are set, and the four connecting rods are arranged in parallel and symmetrically at the four corners of the camera circuit board 230 to ensure the stability of the connection between the camera circuit board 230 and the mounting plate 110.

[0048] The above are merely embodiments of the cell imaging device of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention shall be included in the protection scope of the present invention.

Claims

1. A cell imaging device, characterized in that: It comprises a clamping component, an imaging acquisition component, a focusing component and a shell with a accommodating space; the clamping component, the imaging acquisition component and the focusing component are all mounted on the shell; the clamping component is used to mount the sample to be tested in the accommodating space; the imaging acquisition component is arranged opposite to the sample to be tested and is used to take cell images in the sample to be tested; the focusing component and the imaging acquisition component are both located in the accommodating space, the focusing component is connected to the imaging acquisition component and is used to drive the imaging acquisition component to move so as to adjust the distance between the imaging acquisition component and the sample to be tested.

2. The cell imaging device according to claim 1, characterized in that The cell imaging device further comprises a light source assembly, wherein the light source assembly and the imaging acquisition assembly are respectively arranged on opposite sides of the clamping assembly, so that an installation space for installing a sample to be tested is formed between the light source assembly and the imaging acquisition assembly.

3. The cell imaging device according to claim 2, characterized in that: The housing is provided with a carrying platform for placing the sample to be tested, and the clamping assembly includes at least one clamping member arranged on the carrying platform and used for pressing the sample to be tested onto the carrying platform.

4. The cell imaging device according to claim 3, characterized in that: The supporting platform includes a supporting body provided with a threaded hole, and the clamping member includes a clamping jaw, a clamping screw and a clamping spring. The clamping jaw is provided with a through hole, and the clamping spring is sleeved on the clamping screw; one end of the clamping screw is provided with a screw head, and the other end of the clamping screw passes through the through hole and the threaded hole and is threadedly connected to the threaded hole; one end of the clamping spring abuts against the screw head, and the other end of the clamping spring abuts against the edge of the through hole on the clamping jaw.

5. The cell imaging device according to claim 4, characterized in that: The clamping jaw is also provided with a positioning hole connected to the through hole, the positioning hole is coaxially arranged with the through hole, and the radius of the positioning hole is larger than the radius of the through hole; the end of the clamping spring away from the screw head abuts against the bottom surface of the positioning hole.

6. The cell imaging device according to claim 3, characterized in that: The light source assembly includes a light source circuit board, a light source arranged on the light source circuit board, and a light shielding plate arranged relative to the light source circuit board; the light source is located between the light source circuit board and the light shielding plate; the installation space is formed between the light shielding plate and the imaging acquisition assembly, and a light-transmitting hole is provided on the light shielding plate at a position opposite to the light source, and the light-transmitting hole is used to transmit the light of the light source to illuminate the sample to be tested located in the installation space.

7. The cell imaging device according to claim 6, characterized in that: The carrying platform is provided with a mounting cavity and a mounting groove communicating with the mounting cavity; the light source circuit board, the light source and the light shielding plate are all installed in the mounting cavity; the carrying platform also includes a side panel installed in the mounting groove and having a wire hole; The clamping assembly comprises two clamping members which are installed at intervals on the side panels and are used to press the sample to be tested onto the light shielding plate. The two clamping members are respectively arranged on opposite sides of the light source.

8. The cell imaging device according to claim 1, characterized in that: The shell is also provided with a top opening and a rear opening; the cell imaging device further comprises a top cover detachably connected to the top opening, and a rear cover detachably connected to the rear opening, wherein the top cover, the rear cover and the shell enclose the accommodation space; At least one wire outlet hole is provided on the rear cover.

9. The cell imaging device according to claim 1, characterized in that: The housing is also provided with a limiting hole; the focusing assembly comprises a mounting plate provided with a threaded focusing hole, a focusing screw passing through the limiting hole and threadedly connected to the threaded focusing hole, and a compression spring sleeved on the focusing screw; the imaging acquisition assembly is fixedly mounted on the mounting plate; one end of the compression spring abuts against an end of the mounting plate away from the imaging acquisition assembly, and the other end of the compression spring abuts against an edge of the limiting hole; When the focusing screw rotates in the limiting hole, the mounting plate and the imaging acquisition assembly mounted on the mounting plate are driven to move up and down.

10. The cell imaging device according to claim 9, characterized in that: The shell is also provided with a guide space connected to the accommodating space, the focusing assembly and the imaging acquisition assembly are both located in the accommodating space, the mounting plate is provided with a guide hole, the focusing assembly also includes a guide column passing through the guide hole and installed in the guide space; the guide column is arranged parallel to the focusing screw.

Images