Liquid chromatography mixing equipment

Abstract

The utility model belongs to the technical field of liquid chromatogram preparation, and particularly relates to liquid chromatogram mixing equipment which comprises liquid path pipelines for solution flowing and at least one accommodating cavity for mixing solution, the accommodating cavities are arranged between the liquid path pipelines, and a stirring rotor for stirring the mixed solution is arranged in each accommodating cavity. And the rotating speed of the stirring rotor is controlled by magnetic force. When a solution is mixed in the containing cavity, the stirring rotor in the containing cavity controls the rotating speed of the stirring rotor under the control of magnetic force, so that the mixed solution can be stirred at different rotating speeds, the mixed solution is fully stirred, and the mixed solution which is uniformly mixed and good in mixing effect is obtained.

Description

Technical Field

[0001] The utility model belongs to the technical field of preparative liquid chromatography, and in particular relates to a liquid chromatography mixing device. Background Art

[0002] Preparative liquid chromatography is a powerful technique for separating or purifying one or more target compounds in a mixture. It has become the main purification mode in drug discovery and R&D laboratories for reaction clean-up, natural product purification, and impurity separation, among other uses. The better the mixture is mixed in preparative liquid chromatography, the better the separation or purification will be.

[0003] To this end, the present application needs to design a liquid chromatography mixing device that can ensure the full mixing of two solutions (samples) to improve the analysis and purification effects of preparative liquid chromatography, which is beneficial to the production and development in the medical and pharmaceutical fields. Utility Model Content

[0004] In order to solve the technical problem of making the mixed solution mixed evenly, fully and effectively, a liquid chromatography mixing device is provided, the utility model provides the following technical solutions:

[0005] A liquid chromatography mixing device comprises a liquid pipeline for solution flow and at least one containing chamber for mixing the solution. The containing chambers are arranged between the liquid pipelines. A stirring rotor for stirring the mixed solution is arranged in each containing chamber. The rotation speed of the stirring rotor is controlled by magnetic force.

[0006] Furthermore, the stirring rotor is a rotating wheel structure, and the axis of the stirring rotor is fixed to the bottom of the corresponding accommodating cavity.

[0007] Furthermore, a shell is provided at the bottom of the accommodating cavity, and cylindrical magnets corresponding to the number of stirring rotors are fixed on the top of the shell. The top of each cylindrical magnet is located directly below the corresponding stirring rotor, and a coil is wound around the periphery of each cylindrical magnet.

[0008] Furthermore, switches corresponding to the number of stirring rotors are fixed on the outer surface of the shell, and each switch is used to control the power supply of the coil on each cylindrical magnet.

[0009] Furthermore, each switch has three gears, 45° right turning is the first gear, 90° right turning is the second gear, and 135° right turning is the third gear.

[0010] Furthermore, at least three machine corners are arranged at the bottom of the housing.

[0011] Furthermore, the accommodating cavity includes three cylindrical accommodating cavities arranged in sequence from large to small diameters.

[0012] Furthermore, the liquid pipeline includes an inlet pipeline, an intermediate pipeline, and an outlet pipeline. The inlet end of the inlet pipeline is used for the mixed solution to enter, and the outlet end of the inlet pipeline is inserted in the accommodating cavity with the largest diameter; the intermediate pipeline is used to connect adjacent accommodating cavities, the inlet end of the outlet pipeline is inserted in the accommodating cavity with the smallest diameter, and the outlet end of the outlet pipeline is used for access and use.

[0013] Furthermore, each accommodating cavity is a closed structure, and the liquid pipeline is provided with connecting screws on the outside of the connection with each accommodating cavity. The top of each connecting screw is located outside the top of the accommodating cavity, and the bottom of the connecting screw is located inside the accommodating cavity. A blade ring is provided on the liquid pipeline under each connecting screw, and the top of the blade ring is connected to the bottom of the corresponding connecting screw.

[0014] Furthermore, a heating wire is wound around the periphery of each accommodating cavity.

[0015] Compared with the prior art, the utility model has the following beneficial effects:

[0016] (1) When the containing chamber of the utility model is used to mix solutions, the stirring rotor in the containing chamber controls the rotation speed of the stirring rotor under the control of magnetic force, and then the mixed solution can be stirred at different rotation speeds, so that the mixed solution is fully stirred, thereby obtaining a mixed solution with uniform mixing and good mixing effect.

[0017] (2) The outer periphery of the containing cavity of the utility model is wrapped with a heating wire, which heats the containing cavity. The mixed solution is heated by heat conduction, so that some solutions can be mixed better and more evenly at higher temperatures, and the mixing effect is greatly improved.

[0018] (3) The stirring rotor of the utility model is a "rotating wheel" type structure, which can ensure good fluidity of the solution (sample) in the containing chamber. At the same time, after being filled with the solution, the stirring is more uniform and the mixing efficiency is higher. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the overall structure of the liquid chromatography mixing device of the utility model;

[0020] Figure 2 for Figure 1 sectional view of

[0021] Figure 3 It is a schematic diagram of the structure of the stirring rotor of the utility model in the accommodating chamber;

[0022] Figure 4 This is a schematic diagram of the internal structure of the liquid chromatography mixing device of the utility model;

[0023] Reference numerals:

[0024] 1-inlet pipeline; 2-middle pipeline; 21-middle pipeline one; 22-middle pipeline two; 3-outlet pipeline; 4-connecting screw; 5-accommodating chamber; 51-accommodating chamber one; 52-accommodating chamber two; 53-accommodating chamber three; 6-heating wire; 61-heating wire one; 62-heating wire two; 63-heating wire three; 7-switch; 8-housing; 9-machine corner; 10-blade ring; 11-stirring rotor; 111-stirring rotor one; 112-stirring rotor two; 113-stirring rotor three; 12-cylindrical magnet; 13-coil. DETAILED DESCRIPTION

[0025] The technical solution of the utility model will be clearly described below in conjunction with the accompanying drawings. Obviously, the described embodiments are not all embodiments of the utility model. All other embodiments obtained by ordinary technicians in this field without making creative work are within the protection scope of the utility model.

[0026] It should be noted that the terms "center", "up", "down", "horizontal", "left", "right", "front", "back", "lateral", "longitudinal", etc., indicating the orientation or position relationship are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing the utility model and simplifying the description. They do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the utility model.

[0027] Combination Figure 1 , Figure 2 As shown, the utility model provides a liquid chromatography mixing device, including a liquid pipeline for solution flow and a containing chamber 5 for mixing the solution. The solution enters the containing chamber 5 through the liquid pipeline inlet, is evenly mixed in the containing chamber 5, and then flows out from the liquid pipeline outlet for separation or purification.

[0028] The accommodating chamber 5 includes an accommodating chamber 1 51, an accommodating chamber 2 52, and an accommodating chamber 3 53. The three accommodating chambers 5 are all cylindrical structures. Of course, structures of other shapes can also be selected according to needs. In order from large to small diameters, they are accommodating chamber 1 51, accommodating chamber 2 52, and accommodating chamber 3 53. The accommodating chamber 1 51, accommodating chamber 2 52, and accommodating chamber 3 53 are connected by liquid pipelines.

[0029] The liquid pipeline is a stainless steel pipeline, including an inlet pipeline 1, an intermediate pipeline 1 21, an intermediate pipeline 2 22, and an outlet pipeline 3;

[0030] The inlet pipeline 1 is used to provide a pipeline for two solutions (samples) for mixing to enter. The inlet of the inlet pipeline 1 is connected to a tee, which includes two inlets and one outlet. The two inlets of the tee are respectively connected to the preparation pumps of two different solutions for mixing. The inlet of the inlet pipeline 1 is connected to the outlet of the tee, and the outlet of the inlet pipeline 1 is inserted into the accommodating chamber 1 51;

[0031] The intermediate pipeline 2 is used to connect the two accommodating chambers 5, wherein the intermediate pipeline 1 21 is used to connect the accommodating chamber 1 51 and the accommodating chamber 2 52, one end of the intermediate pipeline 1 21 is inserted in the accommodating chamber 1 51, and the other end is inserted in the accommodating chamber 2 52; the intermediate pipeline 2 22 is used to connect the accommodating chamber 2 52 and the accommodating chamber 3 53, one end of the intermediate pipeline 2 22 is inserted in the accommodating chamber 2 52, and the other end is inserted in the accommodating chamber 3 53;

[0032] The outlet pipeline 3 is used to provide a pipeline for the solution (sample) to finally flow out after being fully stirred and mixed. The inlet end of the outlet pipeline 3 is inserted into the receiving chamber 3 53, and the outlet end of the outlet pipeline 3 is used to connect to the instrument where the mixed solution is finally used. Therefore, the two solutions (samples) transported from the preparation pump connected to the three-way inlet are connected to the three-way outlet for simple mixing, and then flow through the inlet pipeline 1, the receiving chamber 1 51, the intermediate pipeline 1 21, the receiving chamber 2 52, the intermediate pipeline 2 22, the receiving chamber 3 53, and the outlet pipeline 3 in sequence.

[0033] The accommodating chamber 1 51 , the accommodating chamber 2 52 , and the accommodating chamber 3 53 are all closed chambers. The accommodating chamber 1 51 , the accommodating chamber 2 52 , and the accommodating chamber 3 are all provided with connecting screws 4 on the outside of the liquid pipelines at the connection points with the corresponding inlet pipeline 1 , the intermediate pipeline 1 21 , the intermediate pipeline 2 22 , and the outlet pipeline 3. The top of each connecting screw 4 is located outside the accommodating chamber 5 , and the bottom of the connecting screw 4 is located in the accommodating chamber 5 . The bottom of the connecting screw 4 is connected to a blade ring 10 sleeved in the corresponding liquid pipeline. Each connecting screw 4 cooperates with the corresponding blade ring 10 at the bottom to fix the inlet pipeline 1 , the intermediate pipeline 1 21 , the intermediate pipeline 2 22 , and the outlet pipeline 3 . At the same time, the connecting screws 4 increase the closedness of each accommodating chamber 5 .

[0034] like Figure 2 As shown, each accommodating chamber 5 also has a stirring rotor 11 adapted to the diameter of the accommodating chamber 5 for stirring the mixed solution, and the accommodating chamber 1 51 is provided with a stirring rotor 111, the accommodating chamber 2 52 is provided with a stirring rotor 2 112, and the accommodating chamber 3 53 is provided with a stirring rotor 3 113. The stirring rotor 1 111, the stirring rotor 2 112, and the stirring rotor 3 113 have the same structure but different sizes. Taking the stirring rotor 1 111 as an example for analysis, the stirring rotor 2 112 and the stirring rotor 3 113 will not be repeated, and the analysis of the stirring rotor 1 111 is applicable to the stirring rotor 2 112 and the stirring rotor 3 113.

[0035] The stirring rotor 111 is disposed at the bottom of the corresponding containing chamber 51. The stirring rotor 111 is a magnetic rotor. The stirring rotor 111 rotates in the containing chamber 51 under the action of magnetic force, stirring the solution in the containing chamber 51 to make it fully mixed.

[0036] like Figure 3 As shown, the stirring rotor 111 is a unique "wheel" type structure, which further ensures that the solution (sample) in the containing chamber 51 has good fluidity. At the same time, after being filled with the solution, the stirring is more uniform and the mixing efficiency is higher.

[0037] like Figure 1 , Figure 2 As shown, a housing 8 is provided below the three accommodating chambers 5. Figure 2 As shown, three cylindrical magnets 12 are fixed on the top of the inner part of the housing 8, and each cylindrical magnet 12 is correspondingly arranged directly below a stirring rotor 11. The housing 8 plays the role of dust prevention and fixing the cylindrical magnet 12. The cylindrical magnet 12 is made of iron (or any magnetic material).

[0038] like Figure 4 As shown, each cylindrical magnet 12 is uniformly wound with a coil 13 around its periphery. The coil 13 wires on each cylindrical magnet 12 are electrically connected to a switch 7, and each switch 7 has three gears (right twist 45° is the first gear, right twist 90° is the second gear, and right twist 135° is the third gear). As the gear is higher, the current value is greater. Therefore, by controlling the corresponding coil 13 to be energized by each switch 7, the magnetic force generated by the coil 13 can be controlled by controlling the current size, thereby providing different rotation rates for each stirring rotor 11. Therefore, the user selects different gears of the switch 7 according to the requirements of the adaptability, adaptation conditions, etc. of the two solutions (samples), and adjusts the solution mixing speed by the switch 7 to achieve different mixing effects.

[0039] like Figure 1 As shown, each accommodating chamber 5 is wrapped with a heating wire 6, the accommodating chamber 1 51 is wrapped with a heating wire 1 61, the accommodating chamber 2 52 is wrapped with a heating wire 2 62, and the accommodating chamber 3 53 is wrapped with a heating wire 3 63. The heating wire 6 heats the mixed solutions in the three accommodating chambers 5, so that the mixing effect is better, so that the liquid chromatography mixing device has a heating function, and this heating function can be used selectively, and the heating degree can be adjusted. For some solutions, the mixing performance will be better at a higher temperature, the mixing will be more uniform, and the mixing effect will be greatly improved, providing the necessary conditions for subsequent detection. In these specific cases, this heating function can be selected.

[0040] At least three machine corners 9 are arranged at the bottom of the housing 8, so that the liquid chromatography mixing device can be placed on any flat surface such as a desktop, which is convenient to use and has low operating difficulty; it is safe and reliable, and the liquid path flushing is convenient.

[0041] How it works

[0042] First, after the liquid pipeline is connected and ensured to be correct, the power supply of the heating wire 6 wrapped around the periphery of the receiving chamber 5 to be heated is turned on as needed to preheat the corresponding receiving chamber 5. The preheating can ensure that the mixed solution is fully heated when flowing through the receiving chamber 5. The preheating time is about five minutes;

[0043] Then, according to the needs, the three switches 7 are opened respectively, and the gear position is adjusted. Alternatively, one or two switches 7 can be selectively opened, and the current is turned on, and the stirring rotor 11 rotates under the action of the magnetic force;

[0044] At this time, the preparation pump is turned on to allow the two solutions (samples) to be transported to the two inlets of the three-way connection, and then enter the three containing chambers 5 in sequence for step-by-step heating and stirring.

[0045] In summary, it is “connecting the liquid pipeline—preheating the containing chamber 5—starting the stirring function—starting the pump for infusion—fully mixing the solution (sample)”.

[0046] The above technical features constitute the best implementation example of the present utility model, which has strong adaptability and best implementation effect. Non-essential technical features can be added or reduced according to actual needs to meet the needs of different situations.

[0047] Finally, it should be noted that the above content is only used to illustrate the technical solution of the utility model, rather than to limit the protection scope of the utility model. Simple modifications or equivalent substitutions of the technical solution of the utility model by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the utility model.

Claims

1. A liquid chromatography mixing device, comprising a liquid pipeline for solution flow and at least one containing chamber for mixing the solution, wherein the containing chambers are arranged between the liquid pipelines, characterized in that: A stirring rotor for stirring the mixed solution is arranged in each containing cavity, and the rotation speed of the stirring rotor is controlled by magnetic force.

2. The liquid chromatography mixing device according to claim 1, characterized in that: The stirring rotor is a rotating wheel structure, and the axis of the stirring rotor is fixed to the bottom of the corresponding accommodating cavity.

3. The liquid chromatography mixing device according to claim 2, characterized in that: A shell is provided at the bottom of the accommodating cavity, and cylindrical magnets corresponding to the number of stirring rotors are fixed on the top of the shell. The top of each cylindrical magnet is located directly below the corresponding stirring rotor, and a coil is wound around the periphery of each cylindrical magnet.

4. The liquid chromatography mixing device according to claim 3, characterized in that: Switches corresponding to the number of stirring rotors are fixed on the outer surface of the shell, and each switch is used to control the power supply of the coil on each cylindrical magnet.

5. The liquid chromatography mixing device according to claim 4, characterized in that: Each switch has three gears, turning right 45° is the first gear, turning right 90° is the second gear, and turning right 135° is the third gear.

6. The liquid chromatography mixing device according to claim 3, characterized in that: At least three machine corners are arranged at the bottom of the shell.

7. The liquid chromatography mixing device according to claim 2, characterized in that: The accommodating cavity comprises three cylindrical accommodating cavities which are arranged in sequence from large to small in diameter.

8. The liquid chromatography mixing device according to claim 7, characterized in that: The liquid pipeline includes an inlet pipeline, an intermediate pipeline, and an outlet pipeline. The inlet end of the inlet pipeline is used for the mixed solution to enter, and the outlet end of the inlet pipeline is inserted in the accommodating cavity with the largest diameter; the intermediate pipeline is used to connect adjacent accommodating cavities, the inlet end of the outlet pipeline is inserted in the accommodating cavity with the smallest diameter, and the outlet end of the outlet pipeline is used for access and use.

9. The liquid chromatography mixing device according to claim 8, characterized in that: Each accommodating cavity is a closed structure, and the liquid pipeline is provided with connecting screws on the outside of the connection with each accommodating cavity. The top of each connecting screw is located outside the top of the accommodating cavity, and the bottom of the connecting screw is located inside the accommodating cavity. A blade ring is provided on the liquid pipeline under each connecting screw, and the top of the blade ring is connected to the bottom of the corresponding connecting screw.

10. The liquid chromatography mixing device according to any one of claims 1 to 9, characterized in that: A heating wire is wound around the periphery of each accommodating cavity.

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