Magnetic bead adsorption separation equipment with scanning function

Abstract

The utility model discloses magnetic bead adsorption and separation equipment with a scanning function, which comprises a main body, a rotating rod, a sliding seat and a plurality of isolation sleeves, a reciprocating mechanism is arranged on the main body, a sliding plate is connected onto the reciprocating mechanism in a sliding manner, a contact part extends on the sliding plate, an advancing path of the sliding plate on the reciprocating mechanism is parallel to the rotating rod, and a connecting support is mounted on the main body. The two ends of the rotating rod are fixedly connected with cams, the cams are rotationally connected with the connecting support, a sliding groove is formed in the outer side of the rotating rod and spirally surrounds the outer side of the rotating rod, the contact part is clamped into the sliding groove to make sliding contact, a plurality of magnetic bars arranged at intervals are arranged at the bottom of the sliding base, the sliding base is slidably connected with the connecting support, and the cams abut against the top of the sliding base. A plurality of annular bosses extend from the connecting support, and a blind hole is formed in the top of the isolation sleeve. According to the magnetic bead adsorption separation equipment with the scanning function, the contact between the magnetic bar and the magnetic beads is isolated, and cross contamination among multiple batches of magnetic beads is avoided.

Description

Technical Field

[0001] The utility model relates to the field of auxiliary scientific research equipment, in particular to a magnetic bead adsorption and separation device with a scanning function. Background Art

[0002] In the field of immunoassay, antigens or antibodies usually need to use magnetic beads to purify or separate samples. Magnetic bead separation technology uses the unique magnetic responsiveness of magnetic beads. Under the action of an external magnetic field, the magnetic beads drive the coupled targets to aggregate in the direction of the magnetic field, thereby achieving efficient enrichment of the targets to be separated or detected. It is an efficient, rapid, highly specific and high recovery separation and enrichment method. In recent years, it has been widely used in many fields such as medical care, biological testing, food safety, and environmental testing, and has become a popular separation and enrichment method.

[0003] When transporting magnetic beads, the existing equipment transports the magnetic beads by adsorbing the magnetic beads with a magnetic rod. The magnetic rod will come into contact with the magnetic beads during the transportation, which may easily cause cross-contamination between multiple batches of magnetic beads transported by the magnetic rod. Utility Model Content

[0004] The utility model aims to provide a magnetic bead adsorption and separation device with a scanning function, which isolates the contact between the magnetic rod and the magnetic beads and avoids cross contamination between multiple batches of magnetic beads.

[0005] The technical solution adopted by the magnetic bead adsorption separation device with scanning function disclosed in the utility model is:

[0006] The invention comprises a main body, a rotating rod, a sliding seat and a plurality of isolating sleeves, the main body is provided with a reciprocating mechanism, the reciprocating mechanism is slidably connected with a sliding plate, the sliding plate is extended with a contact portion, the travel path of the sliding plate on the reciprocating mechanism is parallel to the rotating rod, a connecting bracket is installed on the main body, cams are fixedly connected with cams at both ends of the rotating rod, the cam is rotatably connected with the connecting bracket, a sliding groove is provided on the outer side of the rotating rod, the sliding groove spirally surrounds the outer side of the rotating rod, the contact portion is stuck in the sliding groove and slides in contact, a plurality of magnetic bars arranged at intervals are provided at the bottom of the sliding seat, the sliding seat is slidably connected with the connecting bracket, the cam touches the top of the sliding seat, the magnetic bar penetrates the connecting bracket, a plurality of annular bosses are extended on the connecting bracket, the magnetic bar is located in the annular boss, and a blind hole is provided on the top of the isolating sleeve.

[0007] As a preferred solution, the main body and the connecting bracket form a U-shaped structure, and the reciprocating mechanism is placed between the main body and the connecting bracket.

[0008] As a preferred embodiment, the reciprocating mechanism includes a motor, a pulley and a slide rail, the motor is fixedly connected to the main body, a driving wheel is fixedly connected to the output shaft of the motor, the pulley is rotatably connected to the main body, a belt is sleeved on the pulley and the driving wheel, the slide plate is fixedly connected to the belt, the slide rail is fixedly connected to the main body, the slide plate is slidably connected to the slide rail, the slide rail and the belt are parallel to each other, and the slide rail and the rotating rod are parallel to each other.

[0009] As a preferred solution, an adjustment plate is slidably connected to the main body, a fixing piece is rotatably connected to the adjustment plate, one end of the fixing piece passes through the adjustment plate and touches the main body, and the pulley is rotatably connected to the adjustment plate.

[0010] As a preferred solution, the connecting bracket is a rectangular hollow structure, the two cams are respectively rotatably connected to the two sides of the connecting bracket, and the annular boss is located at the bottom of the connecting bracket.

[0011] As a preferred solution, two polished rods are fixedly connected to the inner wall of the connecting bracket, the sliding seat is placed in the connecting bracket, the sliding seat is slidably connected to the polished rods, and the two polished rods are respectively close to two ends of the sliding seat.

[0012] As a preferred solution, the slide plate is provided with an expansion bracket, the expansion bracket extends out of the outside of the main body, and a scanner is provided on the expansion bracket.

[0013] As a preferred solution, an optical coupler is provided on the main body, a contact piece extends from the extension bracket, and the contact piece is slidably inserted into the optical coupler.

[0014] The beneficial effects of the magnetic bead adsorption and separation device with scanning function disclosed in the utility model are:

[0015] When transporting magnetic beads, the blind hole of the isolation sleeve is installed on the outer side of the annular boss, and the slide plate is driven to slide left and right by the reciprocating mechanism, and the contact part on the slide plate slides in the slide groove. Since the slide groove is spirally arranged on the outer side of the rotating rod; when the slide plate slides from one end of the reciprocating mechanism to the middle, the contact part slides in the slide groove and pushes the rotating rod to rotate, so that the rotating rod drives the cam to rotate. While the cam rotates, it touches the sliding seat and slides down on the connecting bracket, allowing the magnetic rod to extend into the isolation sleeve, so that the magnetic rod absorbs the magnetic beads. Since the magnetic rod sleeve is provided with an isolation sleeve, the magnetic beads Under the isolation of the isolation sleeve, there is no contact with the magnetic rod; when the slide slides from the middle of the reciprocating mechanism to the other end, the magnetic rod extends a longer length from the connecting bracket. Since the depth of the blind hole of the isolation sleeve is less than the length of the magnetic rod, the magnetic rod pushes the bottom of the blind hole of the isolation sleeve, allowing the isolation sleeve to detach from the annular protrusion, completing the transportation of this batch of magnetic beads, and installing the blind hole of the new isolation sleeve on the outside of the annular boss to transport the next batch of magnetic beads; a new isolation sleeve is used to separate the contact between the magnetic beads and the magnetic rod for each batch of magnetic beads, avoiding cross contamination between multiple batches of magnetic beads. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a structural schematic diagram of a magnetic bead adsorption and separation device with a scanning function of the utility model.

[0017] Figure 2 The utility model is a schematic diagram of the structure of a scanner of a magnetic bead adsorption and separation device with a scanning function.

[0018] Figure 3 The utility model is a schematic diagram of the reciprocating mechanism structure of a magnetic bead adsorption and separation device with a scanning function.

[0019] Figure 4 The utility model is a schematic diagram of the structure of a rotating rod and a sliding seat of a magnetic bead adsorption and separation device with a scanning function.

[0020] Figure 5 The utility model is a schematic diagram of the operation process of a rotating rod and a sliding seat of a magnetic bead adsorption and separation device with a scanning function.

[0021] Figure 6 It is a cross-sectional view of a connecting bracket of a magnetic bead adsorption and separation device with a scanning function according to the utility model. DETAILED DESCRIPTION

[0022] The present invention is further described and illustrated below in conjunction with specific embodiments and accompanying drawings:

[0023] Please refer to Figure 1 .

[0024] The utility model discloses a magnetic bead adsorption and separation device with scanning function, comprising a main body 1, a rotating rod 2, a sliding seat 3 and a plurality of isolation sleeves 4;

[0025] A connecting bracket 11 is installed on the main body 1, and the main body 1 and the connecting bracket 11 form a U-shaped structure, and the interior of the U-shaped structure formed by the main body 1 and the connecting bracket 11 forms a receiving cavity; a blind hole is opened on the top of the isolation sleeve 4, and multiple isolation sleeves 4 are arranged at intervals and placed on an external workbench, the isolation sleeve 4 is located below the main body 1, and an external reagent strip is placed on the outside of the isolation sleeve 4, and an identification code is provided on the external reagent strip.

[0026] Please refer to Figure 1-Figure 3 .

[0027] An open slot is provided on the main body 1, an optical coupler 12 is provided on the outer side of the main body 1, the optical coupler 12 is close to one end of the main body 1, a reciprocating mechanism 13 is provided on the main body 1, the reciprocating mechanism 13 is placed in the receiving cavity between the main body 1 and the connecting bracket 11, a slide plate 134 is slidably connected to the reciprocating mechanism 13, the reciprocating mechanism 13 includes a motor 131, a pulley 132 and a slide rail 133, and the motor 131 is fixedly connected to the main body 1;

[0028] Further, the slide rail 133 is fixedly connected to the main body 1, the slide plate 134 is slidably connected to the slide rail 133, and the open groove is close to the slide rail 133;

[0029] Furthermore, the output shaft of the motor 131 penetrates into the main body 1, and a driving wheel is fixedly connected to the output shaft of the motor 131, and the driving wheel is located in the receiving cavity;

[0030] Further, the main body 1 is slidably connected with an adjustment plate 14, the adjustment plate 14 is rotatably connected with a fixing piece, one end of the fixing piece penetrates the adjustment plate 14 and contacts the main body 1, the pulley 132 is rotatably connected with the adjustment plate 14, the pulley 132 is located in the receiving cavity, a belt 136 is sleeved on the pulley 132 and the driving wheel, the slide plate 134 is fixedly connected with the belt 136, and the slide rail 133 and the belt 136 are parallel to each other;

[0031] Furthermore, the slide plate 134 is provided with an extension bracket 15, one end of the extension bracket 15 extends from the opening groove to the outside of the main body 1, and a scanner 151 is provided on one end of the extension bracket 15, and the scanner 151 faces the bottom of the main body 1; a contact piece 152 extends from the middle of the extension bracket 15, and one end of the contact piece 152 is slidably inserted into the optical coupler 12.

[0032] The output shaft of the motor 131 drives the driving wheel to rotate forward, and the driving wheel drives the slide plate 134 to slide on the slide rail 133 through the belt 136, so that the slide plate 134 slides from one end of the slide rail 133 to the middle of the slide rail 133. The slide plate 134 drives the extension bracket 15 to slide, and the extension bracket 15 pulls the contact member 152 to disengage from the optical coupler 12. After the optical coupler 12 receives the information that the contact member 152 has fallen off, the scanner 151 starts to run. The scanner 151 is driven by the slide plate 134 to scan the identification code on the external reagent strip placed under the main body 1. The slide plate 134 completes the scanning after sliding to the middle of the slide rail 133.

[0033] The output shaft of the motor 131 drives the driving wheel to reverse, and the driving wheel drives the slide plate 134 to slide on the slide rail 133 through the belt 136, so that the slide plate 134 slides from the middle of the slide rail 133 to one end of the slide rail 133. After the slide plate 134 slides to one end of the slide rail 133, one end of the contact member 152 slides into the optical coupler 12. After the optical coupler 12 receives the connection information of the contact member 152, the scanner 151 stops running.

[0034] Please refer to Figure 3-Figure 6 .

[0035] A contact portion 135 extends from the slide plate 134, and the contact portion 135 is close to the connecting bracket 11; the connecting bracket 11 is a rectangular hollow structure, and cams 21 are fixedly connected to both ends of the rotating rod 2, and the two cams 21 are respectively rotatably connected to the two sides of the connecting bracket 11, and the rotating rod 2 is close to the slide plate 134, and the rotating rod 2 and the slide plate 134 are parallel in the travel path on the reciprocating mechanism 13, and the rotating rod 2 and the slide rail 133 are parallel to each other;

[0036] Furthermore, a slide groove 22 is provided on the outer side of the rotating rod 2, and the slide groove 22 spirally surrounds the outer side of the rotating rod 2, and the contact portion 135 is inserted into the slide groove 22 for sliding contact;

[0037] The slide 3 is placed in the connecting bracket 11. Two polished rods 112 are fixedly connected to the inner wall of the connecting bracket 11. The slide 3 is slidably connected with the polished rods 112. The two polished rods 112 are respectively close to the two ends of the slide 3. Two bevels are opened on the top of the slide 3. The two bevels are respectively close to the two ends of the slide 3. The cam 21 touches the bevels on the top of the slide 3.

[0038] A plurality of through holes arranged at intervals are provided at the bottom of the connecting bracket 11, and a plurality of annular bosses 111 extend from the connecting bracket 11, and the center of the annular boss 111 is located at the center of the through hole; a plurality of magnetic rods 31 arranged at intervals are provided at the bottom of the sliding seat 3, and the magnetic rods 31 pass through the through holes, the magnetic rods 31 penetrate the connecting bracket 11, and the magnetic rods 31 are located in the annular bosses 111.

[0039] After the scanner 151 completes scanning of the external reagent strip below the main body 1, the external workbench rises to a certain height to install the blind hole of the isolation sleeve 4 on the outside of the annular boss 111, and the external workbench descends and returns to its original position; the output shaft of the motor 131 drives the driving wheel to rotate forward, and the driving wheel drives the slide plate 134 to slide on the slide rail 133 through the belt 136, so that the slide plate 134 slides from one end of the slide rail 133 to the middle of the slide rail 133, and the contact portion 135 of the slide plate 134 slides in the slide groove 22 during the sliding process, and the contact portion 135 pushes the rotating rod 2 to drive the cam 21 to rotate, and the protrusion of the cam 21 rotates to touch the oblique angle of the slide seat 3, pushing the slide seat 3 to slide down a certain distance on the light rod 112, allowing the magnetic rod 31 to pass through the through hole and extend into the blind hole of the isolation sleeve 4, so that the magnetic beads can fit on the isolation sleeve 4 under the suction of the magnetic rod 31, and the loading of the magnetic beads is completed. At this time, the isolation sleeve 4 separates the contact between the magnetic beads and the magnetic rod 31;

[0040] When the magnetic beads are to be removed, the output shaft of the motor 131 drives the driving wheel to rotate forward, and the driving wheel drives the slide plate 134 to slide on the slide rail 133 through the belt 136, so that the slide plate 134 slides from the middle of the slide rail 133 to the other end of the slide rail 133. During the sliding process of the slide plate 134, the contact part 135 slides in the slide groove 22, and the contact part 135 pushes the rotating rod 2 to drive the cam 21 to rotate. The protrusion of the cam 21 rotates to touch the oblique angle of the slide seat 3, pushing the slide seat 3 to continue to slide down on the light rod 112. Since the depth of the blind hole of the isolation sleeve 4 is less than the length of the magnetic rod 31, the magnetic rod 31 pushes the blind hole of the isolation sleeve 4 The bottom of the hole allows the isolation sleeve 4 to carry the magnetic beads away from the annular protrusion, completing the unloading of the magnetic beads; the output shaft of the motor 131 drives the driving wheel to reverse, and the driving wheel drives the slide plate 134 to slide on the slide rail 133 through the belt 136, so that the slide plate 134 slides from the other end of the slide rail 133 to one end of the slide rail 133. During the sliding process of the slide plate 134, the contact portion 135 slides in the slide groove 22, and the contact portion 135 pushes the rotating rod 2 to drive the cam 21 to rotate and reset. The bevel of the slide seat 3 loses the contact with the cam 21, completing the reset of the slide plate 134, the rotating rod 2 and the cam 21, waiting for the transportation of the next batch of magnetic beads.

[0041] The utility model provides a magnetic bead adsorption and separation device with a scanning function. When the magnetic beads are transported, the blind hole of the isolation sleeve is installed on the outer side of the annular boss, and the slide plate is driven to slide left and right by the reciprocating mechanism, and the contact part on the slide plate slides in the slide groove, because the slide groove is spirally arranged on the outer side of the rotating rod; when the slide plate slides from one end of the reciprocating mechanism to the middle, the contact part slides in the slide groove and pushes the rotating rod to rotate, so that the rotating rod drives the cam to rotate, and the cam touches the sliding seat on the connecting bracket while rotating, so that the magnetic rod extends into the isolation sleeve, so that the magnetic rod adsorbs the magnetic beads. The rod sleeve is provided with an isolation sleeve, so that the magnetic beads do not contact the magnetic rod under the isolation of the isolation sleeve; when the slide slides from the middle of the reciprocating mechanism to the other end, the magnetic rod extends a longer length from the connecting bracket. Since the depth of the blind hole of the isolation sleeve is less than the length of the magnetic rod, the magnetic rod pushes the bottom of the blind hole of the isolation sleeve, so that the isolation sleeve is detached from the annular protrusion, completing the transportation of this batch of magnetic beads, and the blind hole of the new isolation sleeve is installed on the outer side of the annular boss to transport the next batch of magnetic beads; a new isolation sleeve is used to separate the contact between the magnetic beads and the magnetic rod for each batch of magnetic beads, so as to avoid cross contamination between multiple batches of magnetic beads.

[0042] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the utility model, rather than to limit the protection scope of the utility model. Although the utility model has been described in detail with reference to the preferred embodiments, ordinary technicians in this field should understand that the technical solution of the utility model can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the utility model.

Claims

1. A magnetic bead adsorption separation device with scanning function, characterized in that: It comprises a main body, a rotating rod, a sliding seat and a plurality of isolating sleeves, wherein the main body is provided with a reciprocating mechanism, the reciprocating mechanism is slidably connected with a sliding plate, and a contact portion is extended from the sliding plate; The travel path of the slide on the reciprocating mechanism is parallel to the rotating rod, a connecting bracket is installed on the main body, cams are fixedly connected to both ends of the rotating rod, the cams are rotatably connected to the connecting bracket, a sliding groove is opened on the outer side of the rotating rod, the sliding groove spirally surrounds the outer side of the rotating rod, and the contact part is inserted into the sliding groove for sliding contact; A plurality of magnetic bars arranged at intervals are provided at the bottom of the slide, the slide is slidably connected to the connecting bracket, the cam touches the top of the slide, the magnetic bars penetrate the connecting bracket, a plurality of annular bosses extend from the connecting bracket, and the magnetic bars are located in the annular bosses; A blind hole is provided on the top of the isolation sleeve.

2. The magnetic bead adsorption separation device with scanning function as claimed in claim 1, characterized in that: The main body and the connecting bracket form a U-shaped structure, and the reciprocating mechanism is arranged between the main body and the connecting bracket.

3. The magnetic bead adsorption separation device with scanning function as claimed in claim 2, characterized in that: The reciprocating mechanism includes a motor, a pulley and a slide rail, the motor is fixedly connected to the main body, a driving wheel is fixedly connected to the output shaft of the motor, the pulley is rotatably connected to the main body, a belt is sleeved on the pulley and the driving wheel, the slide plate is fixedly connected to the belt, the slide rail is fixedly connected to the main body, the slide plate is slidably connected to the slide rail, the slide rail and the belt are parallel to each other, and the slide rail and the rotating rod are parallel to each other.

4. The magnetic bead adsorption separation device with scanning function as claimed in claim 3, characterized in that: An adjusting plate is slidably connected to the main body, a fixing piece is rotatably connected to the adjusting plate, one end of the fixing piece penetrates the adjusting plate and touches the main body, and the pulley is rotatably connected to the adjusting plate.

5. The magnetic bead adsorption separation device with scanning function as claimed in claim 4, characterized in that: The connecting bracket is a rectangular hollow structure, the two cams are rotatably connected to the two sides of the connecting bracket respectively, and the annular boss is located at the bottom of the connecting bracket.

6. The magnetic bead adsorption separation device with scanning function as claimed in claim 5, characterized in that: Two polished rods are fixedly connected to the inner wall of the connecting bracket, the sliding seat is placed in the connecting bracket, the sliding seat is slidably connected to the polished rods, and the two polished rods are respectively close to two ends of the sliding seat.

7. A magnetic bead adsorption separation device with scanning function according to any one of claims 1 to 6, characterized in that: The slide plate is provided with an expansion bracket, the expansion bracket extends out of the outside of the main body, and a scanner is provided on the expansion bracket.

8. The magnetic bead adsorption separation device with scanning function as claimed in claim 7, characterized in that: An optical coupler is arranged on the main body, a contact piece is extended on the extension bracket, and the contact piece is slidably inserted into the optical coupler.

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