Embedding structure for protecting activity of probiotics
The dual-capsule embedding structure with protective layers and probiotic isolation liquid addresses probiotic survival issues in the digestive tract and storage, enhancing stability and intestinal colonization.
Patent Information
- Application Number
- CN202421092691.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-05-20
- Publication Date
- 2024-12-27
- Estimated Expiration
- 2034-05-20
AI Technical Summary
Probiotics face challenges in surviving the high acid concentration and destructive effects of bile in the digestive tract, leading to reduced activity, and their antioxidant properties are compromised during long-term storage, affecting their effectiveness.
An embedding structure comprising dual capsules with protective layers and a probiotic isolation liquid, utilizing a bipolar antioxidant emulsified protein layer and a metal polyphenol network structure layer to enhance gastric acid tolerance, oxidation resistance, and enzyme decomposition tolerance, along with a polysaccharide layer to improve storage stability and intestinal survival.
The structure effectively enhances probiotic survival and colonization in the intestine by maintaining biological integrity, providing stability and gradual release of the probiotics to adapt to the intestinal environment, improving their activity and intestinal environment.
Smart Images

Figure CN222236623U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of probiotics, in particular to an embedding structure for protecting the vitality of probiotics. Background Art
[0002] Probiotics help improve constipation and diarrhea, and can also regulate the balance of intestinal microecology. Probiotics enter the human intestine in the form of live bacteria, and through growth and metabolism, they promote the formation and maintenance of intestinal flora, inhibit the production of intestinal putrefactive substances, and promote the recovery of intestinal function. They are widely used in clinical practice. The probiotic encapsulation structure can encapsulate the probiotics, which is convenient for the storage of probiotics and for patients to take them.
[0003] However, due to the high acid concentration in the human digestive tract, it is not conducive to the survival of probiotics. At the same time, the bile in the digestive tract will also destroy the antibacterial properties of the probiotic cell membrane and DNA. Especially in the small intestine, the large amount of bile will cause the activity of the probiotics to be seriously reduced, affecting the effectiveness of the probiotics. In addition, when probiotics are stored for a long time, their antioxidant properties are low, which will affect the activity of the probiotics and thus the effectiveness of the probiotics. Therefore, we proposed an embedding structure that protects the vitality of probiotics to solve the above-mentioned problems. Utility Model Content
[0004] The purpose of the utility model is to provide an embedding structure for protecting the vitality of probiotics, so as to solve the problems raised by the above-mentioned background technology that the high acid concentration in the human digestive tract is not conducive to the survival of probiotics in the current market, and the bile in the digestive tract will also destroy the antibacterial properties of the probiotic cell membrane and DNA, especially in the small intestine. The large amount of bile will cause the activity of the probiotics to be seriously reduced, affecting the use effect of the probiotics, and the low antioxidant performance of the probiotics in the case of long-term storage will affect the activity of the probiotics, thereby also affecting the use effect of the probiotics.
[0005] To achieve the above-mentioned object, the utility model provides the following technical solutions: an embedding structure for protecting the vitality of probiotics, comprising a first embedding capsule, a second embedding capsule is arranged on the inner side of the first embedding capsule, the inner sides of the first embedding capsule and the second embedding capsule are both filled with probiotic powder, a card slot is provided on the inner wall of the first embedding capsule, and a card rod is provided on the outer wall of the second embedding capsule;
[0006] The first embedding capsule and the second embedding capsule both include an outer protective layer and an inner protective layer, the inner protective layer is arranged on the inner side of the outer protective layer, and a probiotic isolation liquid is filled between the inner protective layer and the outer protective layer.
[0007] Preferably, the outer protective layer includes a bipolar antioxidant emulsified protein layer and a carbohydrate molecule layer, and the bipolar antioxidant emulsified protein layer is wrapped around the outside of the carbohydrate molecule layer to enhance the probiotics' resistance to hygroscopicity, storage stability, oxidation resistance, gastric acid tolerance and enzyme decomposition tolerance.
[0008] Preferably, the inner protective layer includes a polysaccharide layer and a metal polyphenol network structure layer, and the polysaccharide layer is wrapped around the outside of the metal polyphenol network structure layer, which effectively improves the storage stability of the probiotics, while safely and effectively enhancing the survival rate of the probiotics in the intestine and enhancing its colonization in the intestine.
[0009] Preferably, the position of the clamping rod and the position of the clamping slot are arranged in one-to-one correspondence, and the clamping rod and the clamping slot are engaged with each other. The clamping rod and the clamping slot can be used to limit the sleeve position of the first embedding capsule and the second embedding capsule to prevent them from detaching due to force and prevent the probiotic powder from falling.
[0010] Preferably, the probiotic isolation liquid and the probiotic powder are separated by an inner protective layer to avoid contact between the two. The probiotic isolation liquid and the probiotic powder can be released intermittently to improve the intestinal environment and facilitate the survival of probiotics.
[0011] Preferably, the outer diameter of the second embedding capsule is the same as the inner diameter of the first embedding capsule, and the first embedding capsule is sleeved on the outer side of the second embedding capsule.
[0012] Compared with the prior art, the beneficial effects of the utility model are:
[0013] (1) The encapsulation structure for protecting the vitality of probiotics can effectively improve the storage stability of probiotics without damaging the inherent biological characteristics of probiotics through the metal polyphenol network structure layer and the polysaccharide layer, and at the same time safely and effectively enhance the survival rate of probiotics in the intestine and enhance their colonization in the intestine. The bipolar antioxidant emulsified protein layer and the sugar molecule layer can effectively enhance the anti-hygroscopic deliquescence, storage stability, oxidation resistance, gastric acid tolerance and enzyme decomposition tolerance of probiotics, which is convenient for the storage of probiotic capsules. When the probiotic capsules are swallowed, they can adapt to the intestinal environment to improve the activity of probiotics, and can gradually improve the intestinal environment by successively releasing probiotic isolation liquid and probiotic powder, which is conducive to the survival of probiotics.
[0014] (2) The embedding structure for protecting the vitality of probiotics is that the first embedding capsule is sleeved on the outside of the second embedding capsule. This design is convenient for making probiotic capsules, and the first embedding capsule and the second embedding capsule are limited by the clamping rod and the clamping groove to prevent the first embedding capsule and the second embedding capsule from being separated by force when taking the probiotic capsule, thereby preventing the probiotic powder from falling off. It is also relatively simple to directly take the probiotic powder later. BRIEF DESCRIPTION OF THE DRAWINGS
[0015] Figure 1 It is a schematic diagram of the overall structure of the utility model;
[0016] Figure 2 This is a schematic diagram of the structure of the clamping rod of the utility model;
[0017] Figure 3 This is a schematic diagram of the cross-sectional structure of the utility model;
[0018] Figure 4 This is a schematic cross-sectional view of the first embedding capsule of the utility model;
[0019] Figure 5 It is a schematic diagram of the cross-sectional structure of the second embedding capsule of the utility model.
[0020] In the figure: 1. first embedding capsule; 2. second embedding capsule; 3. probiotic powder; 4. card slot; 5. card rod; 6. outer protective layer; 601. bipolar antioxidant emulsified protein layer; 602. carbohydrate molecule layer; 7. inner protective layer; 701. polysaccharide layer; 702. metal polyphenol network structure layer; 8. probiotic isolation liquid. DETAILED DESCRIPTION
[0021] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.
[0022] See also Figure 1-Figure 5 The utility model provides the following technical solutions: an embedding structure for protecting the vitality of probiotics, comprising a first embedding capsule 1, a second embedding capsule 2 is arranged on the inner side of the first embedding capsule 1, the inner sides of the first embedding capsule 1 and the second embedding capsule 2 are both filled with probiotic powder 3, a card slot 4 is provided on the inner wall of the first embedding capsule 1, and a card rod 5 is provided on the outer wall of the second embedding capsule 2; the position of the card rod 5 and the position of the card slot 4 are arranged in a one-to-one correspondence, the card rod 5 and the card slot 4 are engaged with each other, and the card rod 5 and the card slot 4 can be used to limit the sleeve position of the first embedding capsule 1 and the second embedding capsule 2 to prevent them from detaching by themselves due to force, and to prevent the probiotic powder 3 from falling; the outer diameter of the second embedding capsule 2 is the same as the inner diameter of the first embedding capsule 1, and the first embedding capsule 1 is sleeved on the outer side of the second embedding capsule 2;
[0023] The first embedding capsule 1 is filled with probiotic powder 3, and the second embedding capsule 2 is pressed to deform the soft second embedding capsule 2, and then the second embedding capsule 2 is inserted into the first embedding capsule 1. Then, the pressure on the second embedding capsule 2 is released, and the second embedding capsule 2 is elastically reset, so that the second embedding capsule 2 is closely attached to the inner wall of the first embedding capsule 1, and the clamping rod 5 is clamped into the clamping groove 4 to limit the relative position of the first embedding capsule 1 and the second embedding capsule 2, so as to avoid the first embedding capsule 1 and the second embedding capsule 2 being separated by force when taking the probiotic capsule, thereby preventing the probiotic powder 3 from falling off;
[0024] Furthermore, the first embedding capsule 1 and the second embedding capsule 2 both include an outer protective layer 6 and an inner protective layer 7, the inner protective layer 7 is arranged on the inner side of the outer protective layer 6, and a probiotic isolation liquid 8 is filled between the inner protective layer 7 and the outer protective layer 6; the outer protective layer 6 includes a bipolar antioxidant emulsified protein layer 601 and a carbohydrate molecule layer 602, and the bipolar antioxidant emulsified protein layer 601 is wrapped on the outer side of the carbohydrate molecule layer 602, so as to improve the probiotics' anti-hygroscopicity, storage stability, oxidation resistance, gastric acid tolerance and enzyme decomposition tolerance. The inner protective layer 7 includes a polysaccharide layer 701 and a metal polyphenol network structure layer 702. The polysaccharide layer 701 is wrapped around the outer side of the metal polyphenol network structure layer 702, which effectively improves the storage stability of the probiotics and safely and effectively enhances the survival rate of the probiotics in the intestine and enhances their colonization in the intestine. The probiotic isolation liquid 8 and the probiotic powder 3 are separated by the inner protective layer 7 to avoid contact between the two. The probiotic isolation liquid 8 and the probiotic powder 3 can be released at intervals to improve the intestinal environment and facilitate the survival of the probiotics.
[0025] The first embedding capsule 1 and the second embedding capsule 2 both include an outer protective layer 6 and an inner protective layer 7. The metal polyphenol network structure layer 702 and the polysaccharide layer 701 provided in the inner protective layer 7 can effectively improve the storage stability of the probiotics without damaging the inherent biological characteristics of the probiotics, and at the same time safely and effectively enhance the survival rate of the probiotics in the intestine and enhance their colonization in the intestine. The bipolar antioxidant emulsified protein layer 601 and the carbohydrate molecule layer 602 provided in the outer protective layer 6 can effectively improve the anti-hygroscopicity, storage stability, and oxidation resistance of the probiotics. , gastric acid tolerance and enzyme decomposition tolerance, which is convenient for the storage of probiotic capsules, and when the probiotic capsules are swallowed, they can adapt to the intestinal environment to improve the activity of probiotics. When the outer protective layer 6 is dissolved, the probiotic isolation liquid 8 is first released into the intestine for absorption, and when the inner protective layer 7 is dissolved, the probiotic powder 3 is released into the intestine, which can release the drug to different positions and slowly improve the intestinal environment, which is beneficial to the survival of probiotics. The contents not described in detail in this specification belong to the prior art known to professional and technical personnel in this field.
[0026] Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art may still modify the technical solutions described in the aforementioned embodiments, or make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention shall be included in the protection scope of the present invention.
Claims
1. An embedding structure for protecting the activity of probiotics, comprising a first embedding capsule (1), characterized in that: The second embedding capsule (2) is fitted on the inner side of the first embedding capsule (1), the inner sides of the first embedding capsule (1) and the second embedding capsule (2) are both filled with probiotic powder (3), a clamping groove (4) is provided on the inner wall of the first embedding capsule (1), and a clamping rod (5) is provided on the outer wall of the second embedding capsule (2); The first embedding capsule (1) and the second embedding capsule (2) both comprise an outer protective layer (6) and an inner protective layer (7), wherein the inner protective layer (7) is arranged on the inner side of the outer protective layer (6), and a probiotic isolation liquid (8) is filled between the inner protective layer (7) and the outer protective layer (6).
2. The embedding structure for protecting the activity of probiotics according to claim 1, characterized in that: The outer protective layer (6) comprises a bipolar antioxidant emulsified protein layer (601) and a carbohydrate molecule layer (602), wherein the bipolar antioxidant emulsified protein layer (601) is wrapped around the outer side of the carbohydrate molecule layer (602).
3. The embedding structure for protecting the activity of probiotics according to claim 1, characterized in that: The inner protective layer (7) comprises a polysaccharide layer (701) and a metal polyphenol network structure layer (702), and the polysaccharide layer (701) is wrapped around the outer side of the metal polyphenol network structure layer (702).
4. The embedding structure for protecting the activity of probiotics according to claim 1, characterized in that: The position of the clamping rod (5) and the position of the clamping slot (4) are arranged in one-to-one correspondence, and the clamping rod (5) and the clamping slot (4) are engaged with each other.
5. The embedding structure for protecting the activity of probiotics according to claim 1, characterized in that: The probiotic isolation liquid (8) and the probiotic powder (3) are separated by an inner protective layer (7) to avoid contact between the two.
6. The embedding structure for protecting the activity of probiotics according to claim 1, characterized in that: The outer diameter of the second embedding capsule (2) is the same as the inner diameter of the first embedding capsule (1), and the first embedding capsule (1) is sleeved on the outer side of the second embedding capsule (2).