Disposable chromatography pipeline device

Abstract

The utility model discloses a disposable chromatography pipeline device which comprises a test box body and a flow cell, the test box body is provided with a mounting groove for placing the flow cell, the flow cell comprises a first guide pipe, a liquid storage pipe and a second guide pipe which are sequentially connected, a first limiting block is arranged at the top of the test box body, and a second limiting block is arranged at the bottom of the test box body. The first limiting block extends into the mounting groove to be connected with the first guide pipe in a matched mode, a second limiting block is arranged at the bottom of the test box body, and the second limiting block extends into the mounting groove to be connected with the second guide pipe in a matched mode. When the disposable chromatography pipeline device is used, the first guide pipe is mounted in the first limiting block, and the second guide pipe is mounted in the second limiting block, so that the flow cell is accurately positioned in the mounting groove, the position of the UV light source in the test box body does not need to be repeatedly adjusted, and the debugging time of the disposable chromatography pipeline device is greatly shortened; and product scrapping and direct economic loss caused by displacement of the UV light source emitter are also prevented.

Description

Technical Field

[0001] The utility model relates to the technical field of analysis and purification, in particular to a disposable chromatography pipeline device. Background Art

[0002] Chromatography system is a separation and purification technology widely used in the field of biomedicine. Its purpose is to separate target proteins, DNA or RNA and other biological molecules from complex biological samples. This technology plays a vital role in the field of biomedicine and provides strong support for the production and research and development of biological drugs. In practical applications, in the face of the need for rapid switching of multiple projects and multiple products, in order to reduce the disassembly, cleaning, disinfection, verification and other links of chromatography system components, and to eliminate the risk of introducing contamination, technicians will use a chromatography system based on disposable pipelines. However, when installing disposable pipelines, the upper and lower limits of the circulation pool must be consistent with the positions of the two UV light source emitters. This step currently relies entirely on the subjective judgment of the operator. If the circulation pool cannot be placed in accordance with the position of the UV light source emitter, the UV light source emitter needs to be adjusted repeatedly, which not only takes a long time to debug, but also easily causes damage to the UV light source emitter. Utility Model Content

[0003] In order to overcome the above problems, the utility model provides a disposable chromatography pipeline device, which can accurately install the circulation pool in the installation groove through the first limit block and the second limit block, without repeatedly moving the UV light source emitter.

[0004] The technical solution adopted by the utility model is as follows: a disposable chromatography pipeline device, including a test box and a circulation pool, the test box has a mounting groove for placing the circulation pool, the circulation pool includes a first guide tube, a liquid storage tube and a second guide tube connected in sequence, a first limit block is provided on the top of the test box, the first limit block extends into the mounting groove and is connected to the first guide tube, and a second limit block is provided on the bottom of the test box, the second limit block extends into the mounting groove and is connected to the second guide tube.

[0005] Optionally, the first limit block includes a first support plate and a first limit plate connected to the first support plate at an angle, the first support plate overlaps the top surface of the test box, and the first limit plate is provided with a first receiving groove that cooperates with the first lead tube; the second limit block includes a second support plate and a second limit plate connected to the second support plate at an angle, the second support plate overlaps the bottom surface of the test box, and the second limit plate is provided with a second receiving groove that cooperates with the second lead tube.

[0006] Optionally, the diameter of the first guide tube and the diameter of the second guide tube are both smaller than the diameter of the liquid storage tube, the upper end surface of the liquid storage tube abuts against the lower end surface of the first limiting plate, and the lower end surface of the liquid storage tube abuts against the upper end surface of the second limiting plate.

[0007] Optionally, the first support plate and the second support plate are both mounted on the test box by screws.

[0008] Optionally, it also includes a displacement sensor, a time relay and an alarm that are electrically connected in sequence, and the displacement sensor is arranged at any position on the top surface of the test box body close to the first support plate.

[0009] Optionally, the first containing groove and the second containing groove are arc-shaped grooves, and the first guide tube and the second guide tube are round tubes.

[0010] Optionally, it further includes a base and a cover plate, wherein the base is arranged at the bottom of the test box, one end of the cover plate is hinged to the base, and the other end of the cover plate is movably matched with the installation groove.

[0011] Optionally, a rotating shaft is provided on both sides of the base, and a slot hole for rotationally fitting the rotating shaft is provided on both sides of the cover plate.

[0012] The beneficial effect of the utility model is that the first guide tube is installed in the first limit block and the second guide tube is installed in the second limit block, so that the circulation pool can be accurately positioned in the installation groove, and there is no need to repeatedly adjust the position of the UV light source in the test box, which greatly shortens the debugging time of the disposable chromatography pipeline device and prevents the UV light source emitter from being scrapped and causing direct economic losses due to displacement. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 An exploded view of a disposable chromatography piping device according to an embodiment of the utility model;

[0014] Figure 2 This is an assembly diagram of a disposable chromatography pipeline device proposed in an embodiment of the utility model.

[0015] The marks in the accompanying drawings are: 1. test box; 2. installation groove; 3. first guide tube; 4. liquid storage tube; 5. second guide tube; 6. first support plate; 7. first limit plate; 8. first containing groove; 9. second support plate; 10. second limit plate; 11. second containing groove; 12. displacement sensor; 13. base; 14. cover plate; 15. rotating shaft; 16. slot; 17. UV light source; 18. UV light source emitter. DETAILED DESCRIPTION

[0016] The utility model is described in detail below in conjunction with the accompanying drawings.

[0017] like Figure 1 and2 As shown, this embodiment discloses a disposable chromatography piping device, including a test box 1 and a circulation pool, the test box 1 has a mounting groove 2 for placing the circulation pool, the circulation pool includes a first lead pipe 3, a liquid storage pipe 4 and a second lead pipe 5 connected in sequence, a first limit block is provided on the top of the test box 1, the first limit block extends into the mounting groove 2 and is connected to the first lead pipe 3, and a second limit block is provided at the bottom of the test box 1, the second limit block extends into the mounting groove 2 and is connected to the second lead pipe 5. The first guide tube 3, the liquid storage tube 4 and the second guide tube 5 are an integrally formed structure. When in use, the circulation pool is placed in the installation groove 2, and the two side walls of the installation groove 2 clamp the circulation pool to prevent the circulation pool from sliding. The circulation pool is fixed in the lateral direction (in the direction of the width of the circulation pool) and preliminarily fixed in the radial direction. The first guide tube 3 is installed in the first limit block, and the second guide tube 5 is installed in the second limit block, so that the circulation pool is accurately positioned in the installation groove 2. There is no need to repeatedly adjust the position of the UV light source emitter in the test box 1, which greatly shortens the debugging time of the disposable chromatography piping device and prevents the UV light source emitter 18 from being scrapped and causing direct economic losses due to displacement.

[0018] like Figure 1 As shown, the first limit block includes a first support plate 6 and a first limit plate 7 connected to the first support plate 6 at an angle, the first support plate 6 overlaps the top surface of the test box 1, and the first limit plate 7 is provided with a first receiving groove 8 matched with the first lead pipe 3; the second limit block includes a second support plate 9 and a second limit plate 10 connected to the second support plate 9 at an angle, the second support plate 9 overlaps the bottom surface of the test box 1, and the second limit plate 10 is provided with a second receiving groove 11 matched with the second lead pipe 5. The first support plate 6 and the first limit plate 7 are an integrally formed structure, the second support plate 9 and the second limit part are an integrally formed structure, the first receiving groove 8 limits the first lead pipe 3, and the second receiving groove 11 limits the second lead pipe 5. The angle range of the angle connection here is 0 to 180°.

[0019] like Figure 1 As shown, the diameter of the first guide tube 3 and the diameter of the second guide tube 5 are both smaller than the diameter of the liquid storage tube 4, the upper end surface of the liquid storage tube 4 abuts against the lower end surface of the first limiting plate 7, and the lower end surface of the liquid storage tube 4 abuts against the upper end surface of the second limiting plate 10. The first limiting plate 7 and the second limiting plate 10 fix the liquid storage tube 4, and the second limiting plate 10 also plays a role in supporting the liquid storage tube 4.

[0020] In this embodiment, the first support plate 6 and the second support plate 9 are both mounted on the test box 1 by screws. In other embodiments, the first support plate 6 and the second support rod can also be mounted on the box by a clamping method.

[0021] like Figure 1As shown, this embodiment also includes a displacement sensor 12, a time relay and an alarm which are electrically connected in sequence. The displacement sensor 12 is arranged at any position on the top surface of the test box 1 near the first support plate 6. The displacement sensor 12 is a laser displacement sensor 12, model HG-C1100, the time relay model JSS48A, and the alarm is a small strobe sound and light alarm, model LTE-5061. The displacement sensor 12 is connected to the time relay, and the output end of the time relay is connected to the sound and light alarm. The displacement sensor 12 monitors the position of the circulation pool in real time, and alarms to remind the operator when the displacement of the circulation pool exceeds the acceptable range.

[0022] like Figure 1 As shown, the first receiving groove 8 and the second receiving groove 11 are both arc grooves, and the first guide tube 3 and the second guide tube 5 are both round tubes. In other embodiments, the first guide tube 3 and the second guide tube 5 can be rectangular or other shapes, and the first receiving groove 8 and the second receiving groove 11 are shapes matching the first guide tube 3 and the second guide tube 5.

[0023] like Figure 1 As shown, this embodiment further includes a base 13 and a cover plate 14, the base 13 is arranged at the bottom of the test box 1, one end of the cover plate 14 is hinged with the base 13, and the other end of the cover plate 14 is movably matched with the mounting groove 2. After the flow cell is placed in the mounting groove 2, the cover plate 14 is covered, and the UV light source emitter 18 is started to emit the UV light source 17. The base 13 can be installed at the bottom of the test box 1 by screws, or the base 13 and the test box 1 are integrally formed.

[0024] like Figure 1 As shown, both sides of the base 13 are provided with a rotating shaft 15, and both sides of the cover plate 14 are provided with slots 16 for rotationally matching with the rotating shaft 15. The slots 16 can be a semi-enclosed slot-shaped structure or a hole-shaped structure.

[0025] The above description is only a preferred embodiment of the utility model, and does not limit the patent protection scope of the utility model. Any equivalent structural transformation made using the contents of the utility model specification and drawings, directly or indirectly used in other related technical fields, is also included in the protection scope of the utility model.

Claims

1. A disposable chromatography pipeline device, characterized in that: The invention comprises a test box and a circulation pool, wherein the test box has a mounting groove for placing the circulation pool, and the circulation pool comprises a first guide tube, a liquid storage tube and a second guide tube connected in sequence, a first limit block is arranged on the top of the test box, the first limit block extends into the mounting groove and is connected with the first guide tube, and a second limit block is arranged on the bottom of the test box, the second limit block extends into the mounting groove and is connected with the second guide tube.

2. The disposable chromatography piping device according to claim 1, characterized in that: The first limit block includes a first support plate and a first limit plate connected to the first support plate at an angle, the first support plate overlaps the top surface of the test box, and the first limit plate is provided with a first receiving groove that cooperates with the first guide tube; the second limit block includes a second support plate and a second limit plate connected to the second support plate at an angle, the second support plate overlaps the bottom surface of the test box, and the second limit plate is provided with a second receiving groove that cooperates with the second guide tube.

3. The disposable chromatography piping device according to claim 2, characterized in that: The diameter of the first guide tube and the diameter of the second guide tube are both smaller than the diameter of the liquid storage tube. The upper end surface of the liquid storage tube abuts against the lower end surface of the first limiting plate, and the lower end surface of the liquid storage tube abuts against the upper end surface of the second limiting plate.

4. The disposable chromatography piping device according to claim 2, characterized in that: The first support plate and the second support plate are both mounted on the test box by screws.

5. The disposable chromatography piping device according to claim 2, characterized in that: It also includes a displacement sensor, a time relay and an alarm which are electrically connected in sequence. The displacement sensor is arranged at any position on the top surface of the test box body close to the first support plate.

6. The disposable chromatography piping device according to claim 2, characterized in that: The first containing groove and the second containing groove are arc-shaped grooves, and the first guide tube and the second guide tube are round tubes.

7. The disposable chromatography piping device according to claim 1, characterized in that: It also includes a base and a cover plate, wherein the base is arranged at the bottom of the test box body, one end of the cover plate is hinged with the base, and the other end of the cover plate is movably matched with the installation groove.

8. The disposable chromatography piping device according to claim 7, characterized in that: Rotating shafts are arranged on both sides of the base, and slots for rotating shafts are arranged on both sides of the cover plate.

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