Reagent bottle for chemiluminescence immunoassay

Abstract

The utility model discloses a reagent bottle for chemiluminescence immunoassay, which is provided with an air bag and a linked organ tube, does not need to be held obliquely during use, avoids the situation that internal reagents are spilled out, and can be used for extracting liquid by pinching and holding rubber holding plates on two sides to deform the rubber holding plates so as to extrude the internal air bag. The top of the air bag pushes the sealing plate at the top of the organ pipe, so that the liquid surface of the reagent moves upwards, and the liquid taking device can take liquid continuously; meanwhile, the discharge spout is additionally arranged at the sealing cover, so that a user can selectively use the discharge spout to pour out the internal reagent, and the accuracy of pouring out the reagent is ensured; meanwhile, the liquid taking piece is additionally arranged, so that the liquid taking device can be conveniently positioned and inserted, a suction head of the liquid taking device cannot be in contact with the inner wall of the bottle body, and the cross contamination condition is prevented.

Description

Technical Field

[0001] The utility model belongs to the field of reagent bottles for chemical analysis, and specifically relates to a reagent bottle for chemiluminescent immunoassay. Background Art

[0002] Chemiluminescent immunoassay is a technique that combines highly sensitive chemiluminescent assay technology with highly specific immune response. It is used for the detection and analysis of various antigens, haptens, antibodies, hormones, enzymes, fatty acids, vitamins and drugs. It is the latest immunoassay technology developed after radioimmunoassay, enzyme immunoassay, fluorescence immunoassay and time-resolved fluorescence immunoassay.

[0003] In chemiluminescent immunoassay, the reagent bottles used usually include the following: substrate solution bottle, auxiliary reagent bottle, washing buffer bottle, diluent bottle and quality control bottle. When using chemiluminescent immunoassay reagent bottles, it is necessary to strictly follow the operating procedures to ensure the correct use and storage of reagents to avoid cross contamination and reagent deterioration.

[0004] When using current reagent bottles, in order to ensure that the pipette can fully contact the reagent and reach the preset liquid volume, the reagent bottle is often required to be tilted before being inserted for aspiration. However, in this way, when the internal reagent is sufficient, the reagent will overflow and spill as it is tilted. At the same time, for the pipette, its pipette tip will also contact the inner wall of the reagent bottle, which may cause contamination. Moreover, when the reagent needs to be poured out, the round bottle mouth design is not conducive to accurate pouring operation. Utility Model Content

[0005] In view of the above defects, the utility model provides a reagent bottle for chemiluminescent immunoassay, comprising a bottle body and a sealing member, wherein an inner cavity is provided at the bottom of the bottle body, a partition is fixed to the inner wall of the bottle body, a through hole for communicating with the inner cavity is provided in the middle of the partition, an organ pipe is fixed to the top of the partition, the top of the organ pipe is sealed by a sealing plate, an air bag is provided inside the inner cavity, the top of the air bag passes through the through hole and is separated by the partition to the inner cavity and the organ pipe, notches are provided on both sides of the bottom of the bottle body, and a rubber gripping plate for squeezing the air bag after deformation is fixed to each of the notches;

[0006] The sealing component includes a sealing cover and a sealing block. The interior of the sealing cover is provided with a sealing inner cavity and a connecting inner cavity that communicate with each other. The inner walls of the sealing inner cavity and the connecting inner cavity are respectively provided with a second thread layer and a first thread layer. The second thread layer and the first thread layer are respectively threadedly connected with the threads on the outside of the sealing block and the threads on the outside of the output end of the bottle body. A leakage nozzle is fixed on the side of the sealing cover, and the inner wall of the sealing cover is provided with a discharge hole for connecting the leakage nozzle and the sealing inner cavity.

[0007] Furthermore, the diameter of the sealed inner cavity is greater than the diameter of the communicating inner cavity.

[0008] Through the above technical solution, the connecting inner cavity at the bottom will form a height difference, which is convenient for contacting the sealing block and prevents the sealing block from being placed too deep and inconvenient to be taken out.

[0009] Furthermore, a groove for gripping is provided on the top of the sealing block.

[0010] The above technical solution makes it convenient for users to pinch and rotate.

[0011] Furthermore, the sealing member is fixed with a liquid taking member via a pull rope, and the liquid taking member comprises a T-shaped pipette fixing seat, and a connecting socket and a limit opening are provided inside the pipette fixing seat.

[0012] Through the above technical solution, the wider insertion opening facilitates the insertion of the pipette, while the narrower limiting opening facilitates the limiting of the pipette tip.

[0013] Furthermore, a third thread layer is provided on the bottom surface of the pipette fixing seat for threaded connection with the thread on the outside of the bottle output end.

[0014] Through the above technical solution, a good movable connection effect is achieved between the pipette fixing seat and the bottle body.

[0015] Furthermore, a sealing ring is fixed to the top of the organ pipe, and the outer ring of the sealing ring is attached to the inner wall of the bottle body.

[0016] The above technical solution is used to increase the sealing performance of the gap between the organ pipe and the inner wall of the bottle body, thereby preventing leakage.

[0017] Compared with the prior art, the utility model has the following beneficial effects:

[0018] 1. There is no need to tilt the grip when using it to avoid spilling the internal reagent. When taking liquid, pinch the rubber grips on both sides to deform them, thereby squeezing the internal airbag. The top of the airbag pushes the sealing plate at the top of the organ pipe, so that the liquid level of the reagent moves up, ensuring that the liquid dispenser can continuously take liquid;

[0019] 2. A nozzle is added at the sealing cover, which allows users to use the nozzle to pour out the reagents inside to ensure the accuracy of the reagent pouring; at the same time, a liquid pickup is added to facilitate the positioning and insertion of the liquid pickup device, so that the tip of the liquid pickup device will not contact the inner wall of the bottle body, preventing cross contamination. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a front view of the utility model.

[0021] Figure 2 It is a cross-sectional view of the sealing member in the utility model.

[0022] Figure 3 It is a cross-sectional view of the liquid taking part in the utility model.

[0023] Figure 4 It is a cross-sectional view of the bottle body in the utility model.

[0024] Figure 5 It is a schematic diagram of the sealing ring in the utility model.

[0025] In the figure: 1. bottle body; 2. sealing part; 21. sealing cover; 22. discharge nozzle; 23. discharge hole; 24. sealed inner cavity; 25. connecting inner cavity; 26. second thread layer; 27. first thread layer; 28. sealing block; 3. liquid taking part; 31. pipette fixing seat; 32. third thread layer; 33. socket; 34. limit port; 4. sealing ring; 5. organ pipe; 6. inner cavity; 7. rubber grip plate; 8. air bag. DETAILED DESCRIPTION

[0026] In order to facilitate the understanding of the present invention, the present invention will be described more fully below with reference to the relevant drawings. The drawings provide embodiments of the device. However, the device can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present invention more thorough and comprehensive.

[0027] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "set" should be understood in a broad sense, for example, they can be fixedly connected or set, or detachably connected or set, or integrally connected or set. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0028] Example

[0029] like Figure 1-5As shown, this embodiment provides a reagent bottle for chemiluminescent immunoassay, including a bottle body 1 and a sealing member 2, an inner cavity 6 is provided at the bottom of the bottle body 1, a partition is fixed to the inner wall of the bottle body 1, a through hole for communicating with the inner cavity 6 is provided in the middle of the partition, an organ pipe 5 is fixed to the top of the partition, the top of the organ pipe 5 is sealed by a sealing plate, a sealing ring 4 is fixed to the top of the organ pipe 5, and the outer ring of the sealing ring 4 is attached to the inner wall of the bottle body 1, that is, the reagent inside the bottle body 1 is separated by the sealing plate, and the gap between the organ pipe 5 and the inner wall of the bottle body 1 is filled by the sealing ring 4, and the sealing ring 4 and the organ pipe 5 should be corrosion-resistant rubber The bottle body 1 is made of rubber material, and the outer ring of the organ pipe 5 should also be in contact with the inner wall of the bottle body 1. An airbag 8 is provided inside the inner cavity 6. Preferably, the airbag 8 is filled with liquid. Compared with gas, after stopping pinching, the airbag 8 can be reset by falling down due to its own gravity. The top of the airbag 8 passes through the through hole and is separated by a partition to the inner cavity 6 and the organ pipe 5. Notches are provided on both sides of the bottom of the bottle body 1. Each notch is fixed with a rubber gripping plate 7 for squeezing the airbag 8 after deformation. By setting the notch, the stability of the bottle body 1 itself will not be affected, that is, when placed, due to the support of the bottle body 1 itself, no dumping will occur;

[0030] The seal 2 includes a seal cover 21 and a seal block 28. The seal cover 21 has a seal inner cavity 24 and a communication inner cavity 25 that communicate with each other. The diameter of the seal inner cavity 24 is greater than the diameter of the communication inner cavity 25. The communication inner cavity 25 at the bottom forms a height difference, which is convenient for contacting the seal block 28 and prevents the seal block 28 from being inserted too deep and inconvenient to remove. The inner walls of the seal inner cavity 24 and the communication inner cavity 25 are respectively provided with a second thread layer 26 and a first thread layer 27. The second thread layer 26 and the first thread layer 27 are respectively connected to the thread layer on the outside of the seal block 28. The groove is threadedly connected with the thread on the outside of the output end of the bottle body 1, and a groove for pinching is provided on the top of the sealing block 28, which is convenient for users to pinch and rotate. A leakage nozzle 22 is fixed on the side of the sealing cover 21, and a discharge hole 23 for connecting the leakage nozzle 22 and the sealed inner cavity 24 is provided on the inner wall of the sealing cover 21. When it is necessary to pour out the reagent, the sealing block 28 can be removed, and the reagent inside the bottle body 1 can flow from the discharge hole 23 to the leakage nozzle 22 for discharge. It should be noted that the leakage nozzle 22 is a pot spout structure, which is convenient for controlling the accuracy of pouring;

[0031] The sealing member 2 is fixed with a liquid collecting member 3 by a pull rope, and the liquid collecting member 3 includes a T-shaped pipette fixing seat 31. The interior of the pipette fixing seat 31 is provided with a connected socket 33 and a limit opening 34. The bottom surface of the pipette fixing seat 31 is provided with a third threaded layer 32 that is threadedly connected to the thread on the outside of the output end of the bottle body 1. The wider socket 33 facilitates the insertion of the pipette, and the narrower limit opening 34 facilitates the limiting of the pipette tip. It should be noted that after the tip is limited, its bottom end should pass through the limit opening 34 and extend to the interior of the bottle body 1 to facilitate the absorption of the reagent.

[0032] In the reagent bottle for chemiluminescent immunoassay described in the present embodiment, when using a liquid extractor to absorb reagent, the liquid extractor is inserted into the pipette fixing seat 31 threadedly fixed to the top of the bottle body 1. During the absorption process, the staff pinches and squeezes the two rubber gripping plates 7 with their hands to move the liquid in the internal air bag 8 upward, thereby pushing the sealing plate, so that the sealing plate drives the organ pipe 5 to move upward, raising the liquid level of the reagent to ensure the stability of absorption; after the absorption is completed, when the bottle body 1 is manually cleaned, the sealing plate is pushed down by a high-pressure water gun or a rod-shaped object to compress and reset the organ pipe 5 so that new reagent can be injected again.

[0033] It should be noted that the structure described in the utility model can be implemented in a variety of different forms and is not limited to the described embodiments. Any equivalent transformations made by ordinary technicians in this field using the contents of the utility model specification and drawings, or directly or indirectly applied to other related technical fields, such as the loading and unloading of other items, are included in the protection scope of the utility model.

Claims

1. A reagent bottle for chemiluminescent immunoassay, comprising a bottle body and a sealing member, characterized in that: The bottom of the bottle body is provided with an inner cavity, a partition is fixed to the inner wall of the bottle body, a through hole for communicating with the inner cavity is provided in the middle of the partition, an organ pipe is fixed to the top of the partition, the top of the organ pipe is sealed by a sealing plate, an air bag is provided inside the inner cavity, the top of the air bag passes through the through hole and is separated by the partition to the inner cavity and the organ pipe, notches are provided on both sides of the bottom of the bottle body, and each notch is fixed with a rubber gripping plate for squeezing the air bag after deformation; The sealing component includes a sealing cover and a sealing block. The interior of the sealing cover is provided with a sealing inner cavity and a connecting inner cavity that communicate with each other. The inner walls of the sealing inner cavity and the connecting inner cavity are respectively provided with a second thread layer and a first thread layer. The second thread layer and the first thread layer are respectively threadedly connected with the threads on the outside of the sealing block and the threads on the outside of the output end of the bottle body. A leakage nozzle is fixed on the side of the sealing cover, and the inner wall of the sealing cover is provided with a discharge hole for connecting the leakage nozzle and the sealing inner cavity.

2. A chemiluminescent immunoassay reagent bottle as claimed in claim 1, characterized in that: The diameter of the sealed inner cavity is greater than the diameter of the communicating inner cavity.

3. A chemiluminescent immunoassay reagent bottle as claimed in claim 1, characterized in that: A groove for pinching and gripping is formed on the top of the sealing block.

4. A chemiluminescent immunoassay reagent bottle as claimed in claim 1, characterized in that: The sealing member is fixed with a liquid taking member through a pull rope, and the liquid taking member comprises a T-shaped pipette fixing seat, and a connected plug port and a limit port are provided inside the pipette fixing seat.

5. A chemiluminescent immunoassay reagent bottle as claimed in claim 4, characterized in that: The bottom surface of the pipette fixing seat is provided with a third thread layer which is threadably connected with the thread outside the output end of the bottle body.

6. A chemiluminescent immunoassay reagent bottle as claimed in claim 1, characterized in that: A sealing ring is fixed on the top of the organ pipe, and the outer ring of the sealing ring is attached to the inner wall of the bottle body.

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