Efficient dissolution instrument

Abstract

The utility model discloses an efficient dissolution instrument, which belongs to the technical field of dissolution instruments and comprises a shell, an air cylinder and a telescopic rod are respectively arranged in two sides of the shell, and a lifting frame is connected to the free end of a piston rod of the air cylinder; a water bath box is arranged in the shell, a partition plate is arranged at the top of the water bath box, and a containing groove for containing a dissolution cup is formed in the partition plate; a top seat is arranged above the shell, the bottom of one side of the top seat is connected with a telescopic rod, the other side of the top seat penetrates through the lifting frame and is slidably connected with the lifting frame, a sleeve is arranged above the lifting frame, a threaded rod is in threaded connection with the interior of the sleeve, the bottom of the threaded rod extends into the lifting frame and is fixedly connected with the top of the top seat, and a first motor is erected at the top of the lifting frame. The sleeve is connected with an output shaft of the first motor; a driving part and a stirring paddle which is connected with the driving part and can extend into the dissolution cup for stirring are arranged in the top seat; the technical problem that a stirring paddle of an existing dissolution instrument can only stir at a fixed position relative to a dissolution cup, so that the stirring effect is poor is solved.

Description

Technical Field

[0001] The utility model relates to the technical field of dissolution instruments, in particular to a high-efficiency dissolution instrument. Background Art

[0002] Dissolution instrument is a commonly used drug quality control instrument, which is used to measure the dissolution rate of drugs under specific conditions. Dissolution rate refers to the speed and degree of drug dissolution, and is an important indicator to measure the solubility and release performance of drugs.

[0003] The dissolution instrument is mainly composed of a dissolution tank, a sample tank, a stirrer, a temperature control device, a sampler and a data processing system. The working principle of the dissolution instrument is based on the dissolution kinetics and mass transfer principle of the drug. During the dissolution process, the drug molecules are transferred from the solid phase to the solution phase through processes such as dissolution and diffusion. The dissolution instrument simulates the dissolution and release process of the drug in the body by controlling parameters such as temperature, stirring speed and solution volume, thereby evaluating the solubility and release properties of the drug.

[0004] However, in the existing dissolution apparatus, the stirring paddle can only stir at a fixed position relative to the dissolution cup during the stirring process of the dissolution cup, and the drug may not always remain in the same position during the dissolution process, so the stirring paddle at a fixed position has a poor effect on stirring and dissolving the drug, which is not conducive to dynamically simulating the dissolution and release process of the drug in the human body. Utility Model Content

[0005] The utility model provides a high-efficiency dissolution instrument, which is used to solve the technical problem that in the existing dissolution instrument, during the stirring process of the dissolution cup, the stirring paddle can only stir at a fixed position relative to the dissolution cup, resulting in poor stirring and dissolving effect, which is not conducive to dynamic simulation of the dissolution and release process of the drug in the human body.

[0006] In view of this, the utility model provides a high-efficiency dissolution instrument, comprising:

[0007] The housing has a cylinder and a telescopic rod disposed inside the two sides of the housing, and the free end of the piston rod of the cylinder is connected to a lifting frame;

[0008] A water bath is embedded in the shell, a partition is provided on the top of the water bath, and a receiving groove for placing the dissolution cup is provided on the partition;

[0009] A top seat is arranged above the shell, the bottom of one side of the top seat is connected to the telescopic rod, the other side of the top seat passes through the lifting frame and is slidably connected to the lifting frame, a sleeve is arranged above the lifting frame, a threaded rod is connected to the inner thread of the sleeve, the bottom of the threaded rod extends into the lifting frame and is fixedly connected to the top of the top seat, a first motor is mounted on the top of the lifting frame, and the sleeve is connected to the output shaft of the first motor; a driving member is arranged in the top seat, and the driving member is connected to a stirring paddle that can be extended into the dissolution cup for stirring.

[0010] Optionally, the driving member includes a driven wheel fixedly connected to the stirring paddle, a second motor is provided on the top of the top seat, the output shaft of the second motor passes through the interior of the top seat and is connected to a driving wheel, and the driving wheel and the driven wheel are connected by a conveyor belt.

[0011] Optionally, a plurality of receiving tanks are provided for placing the dissolution cups, and the number of stirring paddles and the number of driven wheels correspond to the number of receiving tanks.

[0012] Optionally, a heating tube is provided at the bottom of the water bath, and a temperature sensor is provided on the inner wall of the water bath.

[0013] Optionally, a groove is provided on the top of the partition, and limiting blocks slidably connected to the groove are provided on the tops of both ends of the dissolution cup.

[0014] Optionally, the stirring blades of the stirring paddle are in an inverted trapezoidal shape.

[0015] Optionally, a supporting leg is provided at the bottom of the shell, and a rubber pad is fixedly connected to the bottom of the supporting leg.

[0016] It can be seen from the above technical solutions that the high-efficiency dissolution apparatus of the utility model has the following advantages:

[0017] The high-efficiency dissolution instrument provided by the utility model can adjust the lifting and lowering of the stirring paddle fixedly connected to the top seat through the arrangement of the cylinder and the telescopic rod, so as to facilitate the adjustment of the initial positions of the stirring paddle and the dissolution cup; through the arrangement of the first motor, the sleeve and the threaded rod, after the first motor rotates, the threaded rod performs reciprocating lifting motion in the sleeve, thereby driving the top seat to continuously perform reciprocating lifting motion in the lifting frame, and then driving the stirring paddle connected to the top seat to perform reciprocating lifting motion in the dissolution cup, so as to better realize the stirring of the medicine in the dissolution cup, improve the stirring and dissolving effect of the medicine, and be more conducive to dynamically simulating the dissolution and release process of the drug in the human body. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the structure of the high-efficiency dissolution instrument provided in the embodiment of the utility model;

[0019] Figure 2 A cross-sectional view of a high-efficiency dissolution apparatus provided in an embodiment of the utility model;

[0020] Figure 3 A top view of the partition provided in the utility model;

[0021] Figure 4 It is a side view of the lifting frame provided in the utility model.

[0022] Wherein, the accompanying drawings are marked as follows:

[0023] 1. Shell; 11. Cylinder; 12. Telescopic rod; 13. Support leg; 14. Rubber pad;

[0024] 2. Water bath; 21. Partition; 22. Receiving groove; 23. Heating tube; 24. Groove; 25. Limit block;

[0025] 3. Top seat; 31. Conveyor belt; 32. Stirring paddle; 321. Stirring blade; 33. Driven wheel; 34. Second motor; 35. Driving wheel;

[0026] 41. lifting frame; 411. through hole; 412. slide rail; 42. first motor; 43. sleeve; 44. threaded rod. DETAILED DESCRIPTION

[0027] In order to make the technical personnel in the technical field better understand the scheme of the utility model, the technical scheme in the embodiment of the utility model will be clearly and completely described below in combination with the drawings in the embodiment of the utility model. Obviously, the described embodiment is only a part of the embodiment of the utility model, not all the embodiments. Based on the embodiment in the utility model, all other embodiments obtained by ordinary technicians in the field without creative work are within the scope of protection of the utility model. In the description of the embodiment of the utility model, it should be noted that the orientation or position relationship indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inside", "outside", etc. is based on the orientation or position relationship shown in the drawings, which is only for the convenience of describing the embodiment of the utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the embodiment of the utility model. In addition, the terms "first", "second", and "third" are only used for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0028] In the description of the embodiments of the present utility model, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the embodiments of the present utility model can be understood according to specific circumstances.

[0029] For easier understanding, see Figure 1 to Figure 2An embodiment of a high-efficiency dissolution instrument provided by the utility model comprises: a shell 1 and a top seat 3 arranged above the shell 1, a cylinder 11 and a telescopic rod 12 are respectively arranged inside the two sides of the shell 1, and the free end of the piston rod of the cylinder 11 is connected to a lifting frame 41; a water bath 2 is embedded in the shell 1, a partition 21 is arranged on the top of the water bath 2, and a plurality of receiving grooves 22 for placing dissolution cups are arranged on the partition 21. When actually used, the dissolution cup is slidably installed on the shell 1 through the receiving grooves 22 and penetrated into the water bath 2; a heating pipe 23 is arranged at the bottom of the water bath 2, which is convenient for heating the liquid in the water bath 2, and then heating the dissolution cup on the water bath 2, and a temperature sensor is arranged on the inner wall of the water bath 2, which can detect the internal temperature of the water bath 2.

[0030] See also Figure 2 and Figure 4 , the bottom of one side of the top seat 3 is connected with the telescopic rod 12, and the other side of the top seat 3 passes through the lifting frame 41 and is slidably connected with the lifting frame 41. Specifically, a horizontal through hole 411 is provided on the lifting frame 41, and the cross-section of the through hole 411 is rectangular. Two vertical walls of the through hole 411 are provided with vertical slide rails 412. The other side of the top seat 3 moves vertically along the slide rails 412. A sleeve 43 is provided above the lifting frame 41. A threaded rod 44 is connected to the inner thread of the sleeve 43. The bottom of the threaded rod 44 extends into the lifting frame 41 and is fixedly connected to the top of the top seat 3. A first motor 42 is mounted on the top of the lifting frame 41, and the sleeve 43 is connected to the output shaft of the first motor 42; the first motor 42 is driven to rotate to drive the sleeve 43 to rotate, thereby driving the threaded rod 44 to rise and fall, and the threaded rod 44 does not rotate. The bottom of the threaded rod 44 is fixedly connected to the top of the top seat 3, thereby driving the top seat 3 to rise and fall;

[0031] Specifically, the first motor 42 is a forward and reverse rotation driving motor. During use, the first motor 42 is driven to rotate 180° in the forward direction and then 180° in the reverse direction, thereby driving the sleeve 43 to rotate. The internal thread of the sleeve 43 is connected to the threaded rod 44, so that the threaded rod 44 moves downward and then upward. Since the bottom of the threaded rod 44 is fixedly connected to the top of the top seat 3, the side of the top seat 3 is slidably connected to the lifting frame 41, thereby driving the top seat 3 to move downward and then upward on the slide rail 412 of the lifting frame 41. The first motor 42 continuously repeats forward and reverse rotation, so that the top seat 3 performs reciprocating lifting motion.

[0032] A driving member is provided inside the top seat 3, and the driving member is connected to a plurality of stirring paddles 32 that can be inserted into the dissolution cup for stirring. The stirring blades 321 of the stirring paddles 32 are in an inverted trapezoidal shape with a larger top and a smaller bottom, which is more conducive to the dissolution of the medicine along with the rotation of the side section of the stirring blades 321 during the stirring process; the number of stirring paddles 32 corresponds to the number of containing tanks 22; the driving member includes a driven wheel 33 fixedly connected to the stirring paddles 32, and a second motor 34 is provided on the top of the top seat 3, the output shaft of the second motor 34 passes through the interior of the top seat 3 and is connected to a driving wheel 35, and the driving wheel 35 and the driven wheel 33 are connected through a conveyor belt 31;

[0033] By driving the second motor 34 to rotate, the second motor 34 drives the driving wheel 35 to rotate, thereby driving the conveyor belt 31 and the driven wheel 33 connected to the conveyor belt 31 to rotate, and then driving the stirring paddle 32 connected to the driven wheel 33 to rotate, so that the stirring paddle 32 can stir the medicine in the dissolution cup.

[0034] See also Figures 2 to 3 In order to better limit the dissolution cup, a groove 24 is provided on the top of the partition 21, and limiting blocks 25 are provided on the tops of both ends of the dissolution cup to be slidably connected to the groove 24. When the dissolution cup extends into the water bath 2 through the receiving groove 22, the limiting blocks 25 at both ends of the dissolution cup are just embedded in the groove 24, so that the dissolution cup is prevented from shaking during the stirring of the medicine in the dissolution cup.

[0035] A supporting leg 13 is provided at the bottom of the housing 1 for supporting the housing 1 , and a rubber pad 14 is fixedly connected to the bottom of the supporting leg 13 to increase the friction between the supporting leg 13 and the placement plane.

[0036] The high-efficiency dissolution instrument provided in the embodiment of the utility model has the following specific working process: adding a proper amount of water to the water bath 2, heating the water in the water bath 2 by controlling the heating tube 23, extending the dissolution cup into the water bath 2 through the receiving groove 22, and ensuring that the lower part of the dissolution cup is immersed in the liquid surface in the water bath 2, the limiting block 25 on the top of the dissolution cup is just embedded in the groove 24 to limit the dissolution cup, pouring the solvent medium into the dissolution cup, heating the solvent medium in the dissolution cup by water bath heating, and controlling the piston rod of the cylinder 11 to move downward, thereby driving the lifting frame 41 connected to the piston rod, the top seat 3 connected to the lifting frame 41, and the stirring paddle 32 fixedly connected to the top seat 3 to move downward together, when the stirring paddle 32 moves to the appropriate position inside the dissolution cup, the piston rod of the cylinder 11 is controlled to stop moving; when the heating temperature of the water bath 2 reaches the preset temperature, the medicine to be subjected to the dissolution test is placed in the dissolution cup, The first motor 42 and the second motor 34 are controlled to start. The start of the second motor 34 will drive the driving wheel 35 to rotate, thereby driving the conveyor belt 31 and the driven wheel 33 to rotate, and then driving the stirring paddle 32 to rotate. The stirring blade 321 on the stirring paddle 32 stirs the medicine in the dissolution cup. At the same time, the first motor 42 rotates forward and reverse alternately, driving the sleeve 43 connected to the first motor 42 to rotate, so that the threaded rod 44 threadedly connected to the sleeve 43 is continuously screwed out of the sleeve 43 and screwed into the sleeve 43, thereby driving the top seat 3 to continuously perform a reciprocating motion of descending and ascending in the lifting frame 41, and then driving the stirring paddle 32 connected to the top seat 3 to continuously perform a descending and ascending motion, that is, the stirring blade 321 of the stirring paddle 32 can perform a reciprocating lifting and lowering motion inside the dissolution cup, avoiding the stirring paddle 32 only being able to stir at a fixed position relative to the dissolution cup, and the stirring effect is better. At the same time, the dissolution and release process of the drug in the human body can be dynamically simulated.

[0037] As described above, the above embodiments are only used to illustrate the technical solutions of the utility model, rather than to limit it. Although the utility model has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that the technical solutions described in the aforementioned embodiments can still be modified, or some of the technical features can be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various embodiments of the utility model.

Claims

1. A high-efficiency dissolution apparatus, characterized in that: include: A shell (1), wherein a cylinder (11) and a telescopic rod (12) are respectively provided inside two sides of the shell (1), and a free end of the piston rod of the cylinder (11) is connected to a lifting frame (41); A water bath (2) is embedded in the housing (1), a partition (21) is provided on the top of the water bath (2), and a receiving groove (22) for placing a dissolution cup is provided on the partition (21); A top seat (3) is arranged above the shell (1); the bottom of one side of the top seat (3) is connected to the telescopic rod (12); the other side of the top seat (3) passes through the lifting frame (41) and is slidably connected to the lifting frame (41); a sleeve (43) is arranged above the lifting frame (41); a threaded rod (44) is connected to the sleeve (43) through an internal thread; the bottom of the threaded rod (44) extends into the lifting frame (41) and is fixedly connected to the top of the top seat (3); a first motor (42) is mounted on the top of the lifting frame (41); the sleeve (43) is connected to the output shaft of the first motor (42); a driving member is arranged inside the top seat (3); the driving member is connected to a stirring paddle (32) that can be extended into the dissolution cup for stirring.

2. A high-efficiency dissolution apparatus according to claim 1, characterized in that: The driving member comprises a driven wheel (33) fixedly connected to the stirring paddle (32); a second motor (34) is provided on the top of the top seat (3); an output shaft of the second motor (34) passes through the interior of the top seat (3) and is connected to a driving wheel (35); the driving wheel (35) and the driven wheel (33) are connected via a conveyor belt (31).

3. A high-efficiency dissolution apparatus according to claim 2, characterized in that: A plurality of the containing grooves (22) for placing the dissolution cups are provided, and the number of the stirring paddles (32) and the number of the driven wheels (33) correspond to the number of the containing grooves (22).

4. A high-efficiency dissolution apparatus according to claim 1, characterized in that: A heating pipe (23) is provided at the bottom of the water bath (2), and a temperature sensor is provided on the inner wall of the water bath (2).

5. A high-efficiency dissolution apparatus according to claim 1, characterized in that: A groove (24) is provided on the top of the partition (21), and limiting blocks (25) slidably connected to the groove (24) are provided on the tops of both ends of the dissolution cup.

6. A high-efficiency dissolution apparatus according to claim 1, characterized in that: The stirring blade (321) of the stirring paddle (32) is in an inverted trapezoidal shape.

7. A high-efficiency dissolution apparatus according to claim 1, characterized in that: A supporting leg (13) is provided at the bottom of the housing (1), and a rubber pad (14) is fixedly connected to the bottom of the supporting leg (13).

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