Mouse intragastric administration device convenient to operate

Abstract

The utility model provides a mouse lavage liquid feeding device convenient to operate, which comprises a lavage tube and a liquid tube, one end of the liquid tube is connected with the lateral portion of the lavage tube, the lavage tube is made of flexible materials, a plurality of rigid embedded tubes are sequentially arranged in the lavage tube, two adjacent embedded tubes are in contact with each other, and one end of the lavage tube is connected with a pressurizing structure. The other end of the lavage tube is provided with a buffer structure used for slowing down the speed of liquid medicine, and the buffer structure is fixedly connected with one of the embedded tubes. The mouse lavage liquid feeding device convenient to operate can be used for lavage a mouse conveniently, quickly and efficiently, the death rate of the mouse is reduced, and the success rate of mouse lavage is increased.

Description

Technical Field

[0001] The utility model belongs to the technical field of biological experiments, in particular to a mouse intragastric liquid feeding device which is easy to operate. Background Art

[0002] Animal experiments on mice are a common method in modern medical biological research. Direct drug administration through a gavage tube during the experiment is a very common way of drug administration. Currently, the gavage devices commonly used for gavage on mice mostly use metal needles and metal medicine tubes, which are hard and have sharp needle tips. The esophagus of mice is relatively thin. If you are not careful during the gavage process, it will cause damage to the throat, esophagus, stomach and other parts of the mouse, and even cause the death of the mouse, resulting in the failure of the experiment. The existing gavage devices also require extremely high technical proficiency of the operator, otherwise it will also damage the health of the mouse and cause gavage failure. In the experiment process that requires multiple gavages, due to the low success rate of gavage, the number of injuries caused to the mouse during the experiment due to gavage is large, affecting the experimental results. Utility Model Content

[0003] The utility model aims to provide a mouse intragastric liquid feeding device which is easy to operate, solves the technical problem of how to conveniently, quickly and efficiently intragastrically feed mice, reduces the mortality rate of mice, and improves the success rate of intragastric feeding of mice.

[0004] A mouse intragastric liquid feeding device that is easy to operate comprises an intragastric liquid feeding tube and a liquid tube whose one end is connected to the side of the intragastric liquid feeding tube. The intragastric liquid feeding tube is made of flexible material and has a plurality of rigid embedded tubes arranged in sequence inside. Two adjacent embedded tubes are in contact with each other. One end of the intragastric liquid feeding tube is connected to a pressurizing structure.

[0005] The other end of the gavage tube is provided with a buffer structure for slowing down the speed of the drug solution, and the buffer structure is fixedly connected to one of the embedded tubes.

[0006] The buffer structure includes a conical shell and a baffle plate sealed on the large end surface of the conical shell, the baffle plate is provided with a plurality of through holes, the small end of the conical shell is provided with an outflow hole, and the baffle plate is coaxially connected to the outer end of the embedded tube.

[0007] The buffer structure includes a hemispherical shell and a baffle plate sealing the opening of the hemispherical shell, the baffle plate is provided with a plurality of through holes, an outflow hole is provided on the side of the hemispherical shell opposite to the baffle plate, and the baffle plate is coaxially connected to the outer end of the embedded tube.

[0008] More preferably, a vertical cross section of the through hole does not pass through the outflow hole.

[0009] The pressurizing structure comprises a butt joint tube, one end of which is connected to one end of the gastric gavage tube, and an air bag connected to the other end of the butt joint tube.

[0010] The gastric gavage tube is a transparent rubber tube, and the embedded tube is made of a transparent glass material.

[0011] The utility model achieves the following significant effects:

[0012] (1) The present application provides a flexible gavage tube and a rigid embedded tube, and two adjacent embedded tubes are in contact. Thus, when in use, the gavage tube not only has the flexibility of a rubber tube, but also has the rigidity of an embedded tube. During gavage of mice, the gavage tube can be appropriately deformed according to the characteristics of the mouse's esophagus, and will not cause damage to the mouse's esophagus and stomach.

[0013] (2) A conical shell or a spherical shell is provided and connected to a baffle, and a through hole is provided on the baffle. After the drug solution passes through the through hole, it is blocked by the inner side of the conical shell and the spherical shell, which plays a buffering role and avoids impact and damage to the stomach of the mouse. The drug solution then slowly flows out through the outflow hole and enters the stomach of the mouse, thereby improving the safety of gavage;

[0014] (3) The gavage tube disclosed in the present application has a suitable texture. It not only has a certain hardness but also a soft surface texture. It can smoothly complete gavage without damaging the mouse esophagus. It has a suitable thickness and is particularly suitable for gavage of young mice. It is easy to clean and can be reused. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a schematic diagram of the structure of the mouse intragastric administration device in Example 1 of the utility model.

[0016] Figure 2 This is a schematic diagram of the structure of the gastric gavage tube in Example 1 of the utility model.

[0017] Figure 3 This is a schematic diagram of the explosion structure of several embedded tubes in Example 1 of the utility model.

[0018] Figure 4 This is a schematic diagram of the connection structure between the conical shell and the baffle in Example 1 of the utility model.

[0019] Figure 5 This is a schematic diagram of the connection structure between the hemispherical shell and the baffle in Example 2 of the utility model.

[0020] Among them, the figures are marked as: 4, liquid tube; 41, valve; 5, air bag; 51, docking tube; 7, gavage tube; 71, covering part; 72, embedded tube; 73, conical shell; 74, baffle; 741, through hole; 75, hemispherical shell. DETAILED DESCRIPTION

[0021] In order to more clearly illustrate the technical features of this solution, this solution is described below through specific implementation methods.

[0022] Example 1

[0023] See also Figure 1-Figure 4 A mouse intragastric liquid feeding device that is easy to operate includes an intragastric tube 7 and a liquid tube 4 whose one end is connected to the side of the intragastric tube 7. The intragastric tube 7 is made of flexible material and has a plurality of rigid embedded tubes 72 arranged in sequence inside. Two adjacent embedded tubes 72 are in contact with each other. One end of the intragastric tube 7 is connected to a pressurizing structure.

[0024] The other end of the gavage tube 7 is provided with a buffer structure for slowing down the speed of the liquid medicine, and the buffer structure is fixedly connected to one of the embedded tubes 72 .

[0025] The buffer structure includes a conical shell 73 and a baffle 74 enclosed on the large end surface of the conical shell 73 . The baffle 74 is provided with a plurality of through holes 741 . The small end of the conical shell 73 is provided with an outflow hole. The baffle 74 is coaxially connected to the outer end of the embedded tube 72 .

[0026] The vertical section of the through hole 741 does not pass through the outflow hole, so that the liquid medicine flowing out of the through hole 741 will impact the inner side of the conical shell 73, playing a buffering effect, and then flow through the outflow hole to the mouse stomach, reducing the impact on the mouse stomach.

[0027] The pressurizing structure includes a butt joint tube 51 , one end of which is connected to one end of the gastric gavage tube 7 , and an air bag 5 connected to the other end of the butt joint tube 51 .

[0028] The gavage tube 7 is a transparent rubber tube, and the plurality of embedded tubes 72 are all made of transparent glass material.

[0029] More preferably, a covering portion 71 is provided at one end of the gavage tube 7 , and the covering portion 71 covers the outer side surface of the conical shell 73 .

[0030] Preferably, scale lines are provided on the outside of the gavage tube 7, so that people can judge the amount of liquid medicine injected into the mouse through the scale lines.

[0031] The specific working process of the utility model is as follows:

[0032] When in use, the gas in the air bag 5 is exhausted so that the outer end of the liquid tube 4 is inserted into the medicine, and the air bag 5 is released. Under the action of atmospheric pressure, the medicine enters the gavage tube 7 through the liquid tube 4, and the buffer structure is slowly inserted into the stomach of the mouse. A valve 41 is provided on the liquid tube 4, and the valve 41 is closed. The air bag 5 is pressurized again to exhaust the air in the air bag 5, and the medicine flows out from the buffer structure along the gavage tube 7, and enters the stomach of the mouse under compression.

[0033] Example 2

[0034] Based on the first embodiment, another embodiment is introduced.

[0035] See also Figure 5 The buffer structure includes a hemispherical shell 75, a baffle 74 enclosing the opening of the hemispherical shell 75, a plurality of through holes 741 being provided on the baffle 74, an outflow hole being provided on the side of the hemispherical shell 75 opposite to the baffle 74, and the baffle 74 being coaxially connected to the outer end of the embedded tube 72.

[0036] More preferably, a covering portion 71 is provided at one end of the gavage tube 7 , and the covering portion 71 covers the outer side surface of the hemispherical shell 75 .

[0037] Technical features not described in the present invention can be achieved through or by adopting existing technologies, and will not be elaborated here. Of course, the above description is not a limitation of the present invention, and the present invention is not limited to the above examples. Changes, modifications, additions or substitutions made by ordinary technicians in this technical field within the essential scope of the present invention should also fall within the scope of protection of the present invention.

Claims

1. A convenient mouse intragastric administration device, characterized in that: The invention comprises a gastric gavage tube (7) and a liquid tube (4) having one end connected to the side of the gastric gavage tube (7). The gastric gavage tube (7) is made of a flexible material and has a plurality of rigid embedded tubes (72) arranged in sequence inside. Two adjacent embedded tubes (72) are in contact with each other. One end of the gastric gavage tube (7) is connected to a pressurizing structure.

2. The easy-to-operate mouse intragastric liquid feeding device according to claim 1, characterized in that: The other end of the gavage tube (7) is provided with a buffer structure for slowing down the speed of the drug solution, and the buffer structure is fixedly connected to one of the embedded tubes (72).

3. The easy-to-operate mouse intragastric liquid feeding device according to claim 2, characterized in that: The buffer structure comprises a conical shell (73), a baffle (74) enclosed on the large end surface of the conical shell (73), a plurality of through holes (741) being provided on the baffle (74), an outflow hole being provided at the small end of the conical shell (73), and the baffle (74) being coaxially connected to the outer end of the embedded tube (72).

4. The easy-to-operate mouse intragastric liquid feeding device according to claim 2, characterized in that: The buffer structure comprises a hemispherical shell (75), a baffle (74) sealing an opening of the hemispherical shell (75), a plurality of through holes (741) being provided on the baffle (74), an outflow hole being provided on a side of the hemispherical shell (75) opposite to the baffle (74), and the baffle (74) being coaxially connected to the outer end of the embedded tube (72).

5. The easy-to-operate mouse intragastric administration device according to claim 1, characterized in that: The pressurizing structure comprises a butt joint tube (51) having one end connected to one end of the gastric gavage tube (7), and an air bag (5) connected to the other end of the butt joint tube (51).

6. The easy-to-operate mouse intragastric administration device according to claim 2, characterized in that: The gastric gavage tube (7) is a transparent rubber tube, and the embedding tube (72) is made of a transparent glass material.

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