Online mixing system

Abstract

The utility model relates to the technical field of biopharmacy, in particular to an online mixing system. The online mixing system comprises a first driving pipeline provided with a first feeding pipe and a first discharging pipe, a second driving pipeline provided with a second feeding pipe and a second discharging pipe and a third driving pipeline provided with a third feeding pipe and a third discharging pipe, and the first discharging pipe and the second discharging pipe are converged. The third discharging pipe is converged with a converging pipeline formed by converging the first discharging pipe and the second discharging pipe, so that a preset solution in the second discharging pipe and a preset solution in the first discharging pipe are subjected to primary mixing, and the solution subjected to primary mixing and a preset solution in the third discharging pipe are subjected to secondary mixing; the device can be used for completing on-line preparation of a buffer solution or on-line lysis of cells, so that the number of production equipment required in actual production is reduced, the installation space is saved, and the production cost and the operation cost are reduced.

Description

Technical Field

[0001] The utility model relates to the technical field of biopharmaceuticals, in particular to an online mixing system. Background Art

[0002] In the production process of modern personalized therapeutic drugs, gene sequences or fragments are often used as carriers. In the downstream processing of biopharmaceuticals, a large number of various buffers are used.

[0003] In the prior art, there are many ways to produce plasmids. The commonly used cell lysis method is to manually control the production equipment of cells for lysis production, but it will bring about the problem of unstable product lysis effect between batches, uneven production quality, and low repeatability. For the production of buffer, it is also necessary to manually control the production equipment of buffer for buffer production. Moreover, the production equipment of cells and the production equipment of buffer are incompatible with each other, which will result in the need to occupy more space to place equipment when carrying out biopharmaceuticals, and it will be collaboratively managed by multiple personnel, which will generate more operating costs.

[0004] Therefore, it is urgent to invent an online mixing system to solve the above problems. Utility Model Content

[0005] The utility model aims to provide an online mixing system to achieve compatibility of online cell lysis and online buffer solution preparation, reduce floor space and lower operating costs.

[0006] To achieve this purpose, the utility model adopts the following technical solutions:

[0007] In-line mixing system, including:

[0008] A first driving pipeline, comprising a first feed pipe and a first discharge pipe;

[0009] A second driving pipeline, including a second feed pipe and a second discharge pipe; and

[0010] A third driving pipeline, including a third feed pipe and a third discharge pipe;

[0011] The first discharge pipe merges with the second discharge pipe, and the third discharge pipe merges with a merged pipeline formed by merging the first discharge pipe and the second discharge pipe.

[0012] As a preferred solution, the first driving pipeline further includes a first driving member, and the first driving member is used to drive the preset solution in the first feeding pipe to be transported to the first discharging pipe;

[0013] The second driving pipeline further includes a second driving member, and the second driving member is used to drive the preset solution in the second feeding pipe to be transported to the second discharging pipe;

[0014] The third driving pipeline also includes a third driving member, and the third driving member is used to drive the preset solution in the third feeding pipe to be transported to the third discharging pipe.

[0015] As a preferred solution, the online mixing system further comprises:

[0016] An integrated control cabinet, wherein the integrated control cabinet is signal-connected to the first drive member, the second drive member, and the third drive member, and the integrated control cabinet can independently control the start and stop of the first drive member, the second drive member, and the third drive member.

[0017] As a preferred solution, a plurality of pipeline fixings are provided on the outer wall of the integrated control cabinet, and the first drive pipeline, the second drive pipeline and the third drive pipeline are all clamped on the pipeline fixings.

[0018] As a preferred solution, the online mixing system further comprises:

[0019] A touch screen is connected to the integrated control cabinet by signal, and the touch screen is used to control the start and stop of components in the integrated control cabinet.

[0020] As a preferred embodiment, a finished liquid discharge pipe and a waste liquid discharge pipe are provided on the pipeline after the first discharge pipe, the second discharge pipe and the third discharge pipe are merged. The finished liquid discharge pipe is used to discharge the solution that meets the processing requirements, and the waste liquid discharge pipe is used to discharge the solution that does not meet the processing requirements.

[0021] As a preferred embodiment, two branch feed pipes are provided on the second feed pipe, and the two branch feed pipes are respectively used to transport a preset solution;

[0022] The two branch feed pipes can simultaneously transport the corresponding preset solutions to complete the online preparation of the buffer solution;

[0023] Among the two branch feeding tubes, only the branch feeding tube corresponding to the solution required for online cell lysis delivers the preset solution to complete the online cell lysis.

[0024] As a preferred solution, the online mixing system further comprises:

[0025] A detection component is arranged on the first discharge pipe, the second discharge pipe and the third discharge pipe that are merged together, and the detection component is used to detect the processing quality of the product.

[0026] As a preferred embodiment, the first discharge pipe, the second discharge pipe and the third discharge pipe are all provided with flow monitoring components, and the flow monitoring components are used to detect the flow sizes of the corresponding preset solution in the first drive pipeline, the corresponding preset solution in the second drive pipeline and the corresponding preset solution in the third drive pipeline, respectively.

[0027] As a preferred solution, each of the branch feed pipes is provided with a flow control valve, and the flow control valve is used to adjust the delivery flow rate and delivery pressure of the corresponding preset solution in each corresponding branch feed pipe.

[0028] Beneficial effects of the utility model:

[0029] The online mixing system provided by the utility model can ensure that the preset solution in the first discharge pipe can be first mixed with the preset solution in the second discharge pipe by ensuring that the first discharge pipe is firstly merged with the second discharge pipe, and the solution after the first-level mixing can be secondarily mixed with the preset solution in the third discharge pipe, by ensuring that the first discharge pipe is firstly merged with the second discharge pipe, and the solution after the first-level mixing is completed can be secondarily mixed with the preset solution in the third discharge pipe, thereby meeting the online preparation requirements of the buffer solution and the online lysis requirements of the cells, and realizing that the online mixing system can be compatible with the production functions of the buffer solution and the production functions of the cell lysis product at the same time, reducing the number of production equipment required in actual production, saving installation space, and reducing production costs and operating costs. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 This is one of the structural schematic diagrams of the online mixing system provided by the embodiment of the utility model;

[0031] Figure 2 This is the second structural schematic diagram of the online mixing system provided by the embodiment of the utility model;

[0032] Figure 3 is a side view of an online mixing system provided by an embodiment of the utility model;

[0033] Figure 4 is a front view of an online mixing system provided by an embodiment of the utility model;

[0034] Figure 5 It is a schematic diagram of pipeline connection of the online mixing system provided by the utility model.

[0035] In the figure:

[0036] 1000, Online mixing system;

[0037] 1. Finished product liquid discharge pipe; 2. Waste liquid discharge pipe;

[0038] 100, first driving pipeline; 110, first feeding pipe; 120, first discharging pipe; 130, first driving member;

[0039] 200, second drive pipeline; 210, second feed pipe; 211, branch feed pipe; 2111, flow control valve; 220, second discharge pipe; 230, second drive member;

[0040] 300, third driving pipeline; 310, third feeding pipe; 320, third discharging pipe; 330, third driving member;

[0041] 400, flow monitoring parts;

[0042] 500, finished liquid conduction valve;

[0043] 600, waste liquid conduction valve;

[0044] 700, detection component; 710, conductivity detection component; 720, pH detection component;

[0045] 800, integrated control cabinet; 810, pipeline fixing member; 811, first clamping groove; 820, supporting member; 821, first clamping hole; 822, second clamping hole;

[0046] 900. Touch screen. DETAILED DESCRIPTION

[0047] In order to make the technical problems solved by the present invention, the technical solutions adopted and the technical effects achieved more clearly, the technical solutions of the present invention are further explained below with reference to the accompanying drawings and through specific implementation methods.

[0048] In the description of the present invention, unless otherwise clearly specified and limited, the terms "connected", "connected", and "fixed" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0049] In the present utility model, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may include that the first and second features are in direct contact, or may include that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, a first feature being "above", "above" and "above" a second feature includes that the first feature is directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being "below", "below" and "below" a second feature includes that the first feature is directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature.

[0050] In the description of this embodiment, the terms "upper", "lower", "left", "right" and other directions or positional relationships are based on the directions or positional relationships shown in the drawings, and are only for the convenience of description and simplified operation, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as a limitation of the present invention. In addition, the terms "first" and "second" are only used to distinguish in the description and have no special meaning.

[0051] In the production process of biopharmaceuticals, gene sequences or fragments are often used as carriers. In the downstream processing of biopharmaceuticals, a large amount of various buffers are used. In the prior art, there are many ways to produce plasmids. The current commonly used cell lysis method is to manually control the production equipment of cells for lysis production, but it will bring about the problem of unstable cell lysis effect between batches, uneven production quality, and low repeatability. For the production of buffers, it is also necessary to manually control the production equipment of buffers for buffer production. Moreover, the production equipment of plasmids is incompatible with the production equipment of buffers, which will result in the need to occupy more space to place equipment when making biopharmaceuticals, and it will be collaboratively managed by multiple personnel, which will generate more operating costs.

[0052] In order to solve the above problems, Figure 1 to Figure 5 As shown, this embodiment provides an online mixing system 1000. The online mixing system 1000 includes a first drive pipeline 100, a second drive pipeline 200 and a third drive pipeline 300, wherein the first drive pipeline 100 includes a first feed pipe 110 and a first discharge pipe 120, the second drive pipeline 200 includes a second feed pipe 210 and a second discharge pipe 220, the third drive pipeline 300 includes a third feed pipe 310 and a third discharge pipe 320, the first discharge pipe 120 merges with the second discharge pipe 220, and the third discharge pipe 320 merges with the merged pipeline after the first discharge pipe 120 and the second discharge pipe 220 merge.

[0053] The online mixing system 1000 ensures that the first discharge pipe 120 and the second discharge pipe 220 merge first, and the third discharge pipe 320 merges with the pipeline after the first discharge pipe 120 and the second discharge pipe 220 merge. This can ensure that the preset solution in the first discharge pipe 120 can first be mixed with the preset solution in the second discharge pipe 220, and the solution after the first mixing can be mixed with the preset solution in the third discharge pipe 320. The requirements for online preparation of the buffer solution and the online lysis of the cells are met, and the online mixing system 1000 can be compatible with the production functions of the buffer solution and the production functions of the cell lysis product, thereby reducing the number of production equipment required in actual production, saving installation space, and reducing production costs and operating costs.

[0054] Further, the first feed pipe 110, the second feed pipe 210 and the third feed pipe 310 are respectively used to transport a preset solution, and two branch feed pipes 211 are provided on the second feed pipe 210, and the two branch feed pipes 211 can transport different types or the same type of preset solutions. The two branch feed pipes 211 can simultaneously transport the corresponding preset solutions to complete the online preparation of the buffer solution, and only the branch feed pipe 211 corresponding to the solution required for online cell lysis in the two branch feed pipes 211 transports the preset solution to complete the online lysis of the cells, so as to achieve compatibility with the online preparation function of the buffer solution and the online cell lysis function.

[0055] Specifically, four material bags are correspondingly arranged in the online mixing system 1000, and the four material bags are respectively arranged corresponding to the first feed pipe 110, the two branch feed pipes 211 and the third feed pipe 310. When it is necessary to complete the online preparation of the buffer solution, the preset solution in the first feed pipe 110 is a pharmaceutical aqueous solution, the preset solution in any one of the two branch feed pipes 211 is an acidic solution, the preset solution in the other is an alkaline solution, and the preset solution in the third feed pipe 310 is a saline solution. First, the acidic solution and the alkaline solution are pre-mixed, and after the pre-mixing of the acidic solution and the alkaline solution is completed, the first-level mixing is carried out with the pharmaceutical water in the first feed pipe 110, and after the first-level mixing is completed, the second-level mixing is carried out with the saline solution in the third feed pipe 310, so that the online preparation of the buffer solution is realized.

[0056] When online cell lysis is required, the preset solution in the first feed tube 110 is an alkaline solution, the preset solution in at least one of the two branch feed tubes 211 is a cell solution, and the preset solution in the third feed tube 310 is an acidic solution.

[0057] When performing online lysis of the cell solution, the cell solution in the branch feed pipe 211 is first mixed with the alkaline solution in the first feed pipe 110, and the solution after the primary mixing is secondarily mixed with the acidic solution in the third feed pipe 310, thereby achieving online lysis of the cells.

[0058] In addition, in this embodiment, the online mixing system 1000 also includes four liquid storage bag hanging brackets, each of which is arranged corresponding to a material bag, and the hanging brackets are used to place material bags of pre-configured solutions to meet the requirements of fully automatic operation.

[0059] In this embodiment, in order to further improve the preparation efficiency of the buffer solution and the preparation efficiency of the cell lysis product, each pipeline of the online mixing system 1000 is a detachable disposable silicone hose. After the preparation of the buffer solution or the preparation of the cell lysis product is completed, each pipeline in the online mixing system 1000 can be directly removed and a new pipeline can be installed without cleaning, so as to improve the preparation efficiency of the buffer solution or the cell lysis product, and the use-and-disposable method will not cause cross-contamination of products of different batches, further ensuring the preparation quality of the buffer solution or the cell lysis solution.

[0060] In other embodiments, each pipeline in the online mixing system 1000 may also be a stainless steel pipe or other plastic pipe, and the assembly of the online mixing system 1000 can be completed by disassembling and assembling the stainless steel pipe or other plastic pipe. It only needs to ensure that each pipeline in the online mixing system 1000 can realize the conveying function and is compatible with the conveying solution. This embodiment does not make specific limitations.

[0061] As an optional solution, the first driving pipeline 100 further includes a first driving member 130, which is used to drive the preset solution in the first feeding pipe 110 to be transported to the first discharging pipe 120, the second driving pipeline 200 further includes a second driving member 230, which is used to drive the preset solution in the second feeding pipe 210 to be transported to the second discharging pipe 220, and the third driving pipeline 300 further includes a third driving member 330, which is used to drive the preset solution in the third feeding pipe 310 to be transported to the third discharging pipe 320. By respectively arranging the first driving member 130 in the first driving pipeline 100, the second driving member 230 in the second driving pipeline 200, and the third driving member 330 in the third driving pipeline 300, it is possible to facilitate the transportation and mixing of the preset solutions in the material bag, thereby improving the preparation efficiency of the buffer solution or the cell lysis solution. It should be noted that, in this embodiment, the first driving member 130, the second driving member 230 and the third driving member 330 are all electric pumps, the electric pumps have a stable output flow rate, low pulse, and the pump head structure is suitable for biopharmaceutical processes. In other embodiments, the first driving member 130, the second driving member 230 and the third driving member 330 may also be pneumatic pumps, which are not specifically limited in this embodiment.

[0062] Further, the online mixing system 1000 also includes an integrated control cabinet 800, wherein the integrated control cabinet 800 is connected to the first drive member 130, the second drive member 230 and the third drive member 330 by signal, and the integrated control cabinet 800 can individually control the start and stop of the first drive member 130, the second drive member 230 and the third drive member 330. By controlling the start and stop of the first drive member 130, the second drive member 230 and the third drive member 330 through the integrated control cabinet 800, it is convenient for the staff to control the start and stop of the preparation process at any time. It should be noted that in this embodiment, the first drive member 130, the second drive member 230 and the third drive member 330 are all started synchronously, and the first discharge pipe 120 is used to merge with the second discharge pipe 220, and the third discharge pipe 320 is used to merge with the first discharge pipe 120 and the second discharge pipe 220. The structure setting mode of merging the converging pipeline after merging is realized to achieve the primary mixing and secondary mixing of the solution. In other embodiments, if online lysis of the plasmid is performed, the second driving member 230 and the first driving member 130 may be started first to achieve primary mixing of the preset solution in the first discharge pipe 120 and the preset solution in the second discharge pipe 220. After the primary mixing is completed, the third driving member 330 may be started to achieve secondary mixing of the solution after the primary mixing and the preset solution in the third discharge pipe 320. This embodiment does not make specific limitations.

[0063] In addition, if the buffer solution is prepared online, the second driving member 230 can be started first to pre-mix the two preset solutions in the two branch feed pipes 211, and then the second driving member 230 and the first driving member 130 can be started to achieve primary mixing of the preset solution in the first discharge pipe 120 and the pre-mixed preset solution in the second discharge pipe 220. After the primary mixing is completed, the third driving member 330 is started to achieve secondary mixing of the solution after the primary mixing and the preset solution in the third discharge pipe 320. This embodiment does not make specific limitations.

[0064] Furthermore, a finished liquid discharge pipe 1 and a waste liquid discharge pipe 2 are provided on the pipeline after the first discharge pipe 120, the second discharge pipe 220 and the third discharge pipe 320 are all merged. The finished liquid discharge pipe 1 is used to discharge the solution that meets the processing requirements, and the waste liquid discharge pipe 2 is used to discharge the solution that does not meet the processing requirements. By providing the finished liquid discharge pipe 1 and the waste liquid discharge pipe 2, it is convenient to discharge the finished solution that meets the processing requirements and the waste solution that does not meet the processing requirements, thereby facilitating the collection of the solution.

[0065] In this embodiment, the online mixing system 1000 further includes a finished liquid conduction valve 500 and a waste liquid conduction valve 600, wherein the finished liquid conduction valve 500 is arranged on the finished liquid discharge pipe 1, and the finished liquid conduction valve 500 is used to control the conduction and isolation of the finished liquid discharge pipe 1, and the waste liquid conduction valve 600 is arranged on the waste liquid discharge pipe 2, and the waste liquid conduction valve 600 is used to control the conduction and isolation of the waste liquid discharge pipe 2. It should be noted that in this embodiment, the finished liquid conduction valve 500 and the waste liquid conduction valve 600 are both switch valves, and the finished liquid conduction valve 500 and the waste liquid conduction valve 600 are both provided with a first accommodating groove, and the finished liquid discharge pipe 1 and the waste liquid discharge pipe 2 are both overlapped on the corresponding first accommodating groove, so as to fix the finished liquid discharge pipe 1 and the waste liquid discharge pipe 2 on the basis of controlling the conduction and blocking of the finished liquid discharge pipe 1 and the waste liquid discharge pipe 2. The switch valve has a simple structure and is easy to assemble and disassemble. In other embodiments, the finished liquid conduction valve 500 and the waste liquid conduction valve 600 may also be proportional valves to adjust the discharge rate of the finished solution along the finished liquid discharge pipe 1 and the discharge rate of the waste solution along the waste liquid discharge pipe 2, which is not specifically limited in this embodiment.

[0066] Specifically, the online mixing system 1000 also includes a detection component 700, which is arranged on the first discharge pipe 120, the second discharge pipe 220 and the third discharge pipe 320 that converge together. The detection component 700 is used to detect the processing quality of the product. The detection component 700 is connected to the integrated control cabinet 800 by signal. The detection component 700 can transmit the detection information to the integrated control cabinet 800, and the integrated control cabinet 800 can control the conduction and isolation of the finished liquid conduction valve 500 and the conduction and isolation of the waste liquid conduction valve 600 according to the detection information of the detection component 700.

[0067] When the detection component 700 detects that the product meets the actual processing requirements, the integrated control cabinet 800 starts the finished liquid conduction valve 500 and closes the waste liquid conduction valve 600, so that the product is discharged along the finished liquid discharge pipe 1. When the detection component 700 detects that the product does not meet the actual processing requirements, the integrated control cabinet 800 starts the waste liquid conduction valve 600 and closes the finished liquid conduction valve 500, so that the product is discharged along the waste liquid discharge pipe 2, realizing the automatic distinction and discharge of finished products and defective products.

[0068] Further, the detection assembly 700 includes a conductivity detection member 710 and a pH detection member 720, wherein the conductivity detection member 710 is used to detect the conductivity of the product, and the pH detection member 720 is used to detect the pH value of the product. When the detection results of the conductivity detection member 710 and the pH detection member 720 meet the processing requirements, the integrated control cabinet 800 will open the finished liquid conduction valve 500 and close the waste liquid conduction valve 600. When any one or all of the detection results of the conductivity detection member 710 and the pH detection member 720 do not meet the processing requirements, the integrated control cabinet 800 will open the waste liquid conduction valve 600 and close the finished liquid conduction valve 500. The specific structure and detection principle of the conductivity detection member 710 and the pH detection member 720 belong to the prior art and will not be repeated here. In other embodiments, the detection assembly 700 may also include but is not limited to the conductivity detection member 710 and the pH detection member 720, which are not specifically limited in this embodiment.

[0069] In addition, in order to facilitate the fixing of the first drive pipeline 100, the second drive pipeline 200 and the third drive pipeline 300, a plurality of pipeline fixing members 810 are fixed on the outer wall of the integrated control cabinet 800, and the first drive pipeline 100, the second drive pipeline 200 and the third drive pipeline 300 are all clamped on the pipeline fixing member 810. Specifically, the pipeline fixing member 810 is provided with a first clamping groove 811, and the pipelines on the first drive pipeline 100, the second drive pipeline 200 and the third drive pipeline 300 are all clamped and fixed in the first clamping groove 811. In other embodiments, the number of pipeline fixing members 810, the installation position and the number of first clamping grooves 811 can also be adjusted according to actual needs, and this embodiment does not specifically limit them.

[0070] In addition, in this embodiment, a pipe fixing part 810 for fixing the finished liquid discharge pipe 1 and the waste liquid discharge pipe 2 is also provided on the integrated control cabinet 800. The finished liquid discharge pipe 1 and the waste liquid discharge pipe 2 are respectively clamped and fixed in the first clamping groove 811 in the corresponding pipe fixing part 810, so that the integration effect is good and it is convenient to store and organize the various pipelines in the online mixing system 1000.

[0071] Furthermore, if Figure 2 As shown, the integrated control cabinet 800 is further provided with a supporting member 820, wherein the supporting member 820 is provided with a first clamping hole 821 and a second clamping hole 822, the conductivity detection member 710 passes through the first clamping hole 821 and is clamped and fixed with the first clamping hole 821, and the pH detection member 720 passes through the second clamping hole 822 and is clamped and fixed with the second clamping hole 822. In other embodiments, the number and installation position of the supporting member 820 can also be adjusted according to actual needs, and this embodiment does not specifically limit it.

[0072] As an optional solution, the first discharge pipe 120, the second discharge pipe 220 and the third discharge pipe 320 are all provided with flow monitoring components 400, which are used to detect the flow of the corresponding preset solution in the first drive pipeline 100, the corresponding preset solution in the second drive pipeline 200 and the corresponding preset solution in the third drive pipeline 300. By monitoring the flow of the respective preset solutions in the first drive pipeline 100, the second drive pipeline 200 and the third drive pipeline 300, the control system in the integrated control cabinet 800 can adjust the driving power of the first drive component 130, the second drive component 230 and the third drive component 330 according to the information of the preset value and the actual detection value, so as to achieve accurate proportion mixing of the buffer solution or accurate proportion lysis of the cells. It should be noted that, in this embodiment, the flow monitoring component 400 is a photoelectric sensor or an ultrasonic sensor, and a clamp assembly is provided in the flow monitoring component 400. The pipes in the first discharge pipe 120, the second discharge pipe 220 and the third discharge pipe 320 pass through the clamp assembly in the flow monitoring component 400, so that the flow monitoring component 400 can monitor the flow of the solution.

[0073] In addition, each branch feed pipe 211 is provided with a flow control valve 2111, and the flow control valve 2111 is used to adjust the delivery flow and delivery pressure of the corresponding preset solution in each corresponding pipeline, so as to further improve the preparation accuracy of the buffer solution or cell lysis solution. It should be noted that the flow control valves 2111 are all proportional valves, and each proportional valve is provided with a second accommodating groove, and each branch feed pipe 211 is overlapped in the second accommodating groove, so as to realize the fixation of the branch feed pipe 211 on the basis of controlling the conduction and blocking of the branch feed pipe 211, and the two proportional valves are connected to the integrated control cabinet 800 by signal, and the integrated control cabinet 800 can individually control the conduction degree of each flow control valve 2111, and then control the delivery flow and delivery pressure of the corresponding preset solution in each branch feed pipe 211.

[0074] In addition, in other embodiments, on the basis of each branch feed pipe 211 being provided with a flow control valve 2111, flow control valves 2111 can be provided in the first feed pipe 110 and the third feed pipe 310 to adjust the delivery flow rate and delivery pressure of the preset solution in the first feed pipe 110 and the delivery flow rate and delivery pressure of the preset solution in the third feed pipe 310, thereby further improving the preparation accuracy of the buffer solution or the cell lysis solution, which is not specifically limited in this embodiment. In addition, in other embodiments, the flow control valve 2111 in the branch feed pipe 211 can also be adjusted to a switch valve in combination with actual use requirements, which is not specifically limited in this embodiment.

[0075] To further facilitate the staff to control the preparation process of the buffer solution or the cell lysis solution, the online mixing system 1000 also includes a touch screen 900, which is connected to the integrated control cabinet 800 by signal, and the touch screen 900 can control the start and stop of the components in the integrated control cabinet 800. The specific structure of the touch screen 900 and the integrated control cabinet 800 and the control principle between them belong to the prior art and will not be described in detail here.

[0076] Obviously, the above embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the implementation methods of the present invention. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all implementation methods here. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention shall be included in the protection scope of the claims of the present invention.

Claims

1. Online mixing system, characterized in that, include: A first driving pipeline (100) comprising a first feed pipe (110) and a first discharge pipe (120); A second driving pipeline (200), comprising a second feed pipe (210) and a second discharge pipe (220); and A third driving pipeline (300), comprising a third feed pipe (310) and a third discharge pipe (320); The first discharge pipe (120) merges with the second discharge pipe (220), and the third discharge pipe (320) merges with a merged pipeline formed by merging the first discharge pipe (120) and the second discharge pipe (220); The first driving pipeline (100) further comprises a first driving member (130), wherein the first driving member (130) is used to drive the preset solution in the first feeding pipe (110) to be transported to the first discharging pipe (120); The second driving pipeline (200) further comprises a second driving member (230), wherein the second driving member (230) is used to drive the preset solution in the second feeding pipe (210) to be transported to the second discharging pipe (220); The third driving pipeline (300) further comprises a third driving member (330), wherein the third driving member (330) is used to drive the preset solution in the third feeding pipe (310) to be transported to the third discharging pipe (320); The online mixing system further comprises an integrated control cabinet (800) connected to the first drive member (130), the second drive member (230) and the third drive member (330) by signals, the integrated control cabinet (800) being capable of independently controlling the start and stop of the first drive member (130), the second drive member (230) and the third drive member (330), and a plurality of pipeline fixing members (810) are arranged on an outer wall of the integrated control cabinet (800), and the first drive pipeline (100), the second drive pipeline (200) and the third drive pipeline (300) are all clamped on the pipeline fixing members (810).

2. The online mixing system according to claim 1, characterized in that: The online mixing system also includes: A touch screen (900), the touch screen (900) being connected to the integrated control cabinet (800) by signal, the touch screen (900) being used to control the start and stop of components in the integrated control cabinet (800).

3. The online mixing system according to claim 1 or claim 2, characterized in that: A finished liquid discharge pipe (1) and a waste liquid discharge pipe (2) are provided on the pipeline after the first discharge pipe (120), the second discharge pipe (220) and the third discharge pipe (320) are all merged. The finished liquid discharge pipe (1) is used to discharge the solution that meets the processing requirements, and the waste liquid discharge pipe (2) is used to discharge the solution that does not meet the processing requirements.

4. The online mixing system according to claim 1 or claim 2, characterized in that: The second feed pipe (210) is provided with two branch feed pipes (211), and the two branch feed pipes (211) are respectively used to transport a preset solution; The two branch feed pipes (211) are capable of simultaneously conveying the corresponding preset solutions to complete the online preparation of the buffer solution; Of the two branch feed pipes (211), only the branch feed pipe (211) corresponding to the solution required for online cell lysis delivers the preset solution to complete online cell lysis.

5. The online mixing system according to claim 1 or claim 2, characterized in that: The online mixing system also includes: A detection component (700), wherein the detection component (700) is arranged on the first discharge pipe (120), the second discharge pipe (220), and the third discharge pipe (320) that are merged together, and the detection component (700) is used to detect the processing quality of the product.

6. The online mixing system according to claim 1 or claim 2, characterized in that: The first discharge pipe (120), the second discharge pipe (220) and the third discharge pipe (320) are each provided with a flow monitoring component (400), and the flow monitoring component (400) is used to detect the flow rates of the corresponding preset solution in the first drive pipeline (100), the corresponding preset solution in the second drive pipeline (200) and the corresponding preset solution in the third drive pipeline (300), respectively.

7. The online mixing system according to claim 4, characterized in that: Each of the branch feed pipes (211) is provided with a flow control valve (2111), and the flow control valve (2111) is used to adjust the delivery flow rate and delivery pressure of the corresponding preset solution in each corresponding branch feed pipe (211).

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