Mouse living body imaging detection device

Abstract

The utility model provides a mouse living body imaging detection device, belongs to the technical field of tumor experiment detection, and aims to solve the problems that a mouse narcotized by an existing mouse living body imaging detection device possibly shakes or convulses unconsciously, and the convulsion of the mouse can change a detection position to influence detection. Comprising an imaging detection body; the imaging camera is arranged in the imaging detection main body; the lifting detection table is fixedly mounted in the imaging detection main body; the anesthesia main body is fixedly mounted at the upper part of the lifting detection table; the anesthesia tube is in threaded connection with the interior of the anesthesia main body; the mouse fixing table is placed above the lifting detection table; the limb fixing assembly is arranged above the mouse fixing table; the head fixing assembly is arranged above the mouse fixing table. The fixing device has the advantages of stability in fixation, falling prevention, simplicity in operation and the like.

Description

Technical Field

[0001] The utility model belongs to the technical field of tumor experimental detection, and more specifically, particularly relates to a mouse living body imaging detection device. Background Art

[0002] During tumor experimental detection, researchers usually implant fluorescently labeled tumor cells or tumor-related genes into mice to establish a tumor model, and then monitor these fluorescent markers in real time. By recording and analyzing image data, important information about tumor growth rate, metastasis path, etc. can be obtained. When monitoring fluorescent markers in real time, a mouse live imaging detection device is required. The existing mouse live imaging detection device is mainly composed of an imaging system, an anesthesia system and a data analysis system. After the imaging system captures the fluorescence and bioluminescence signals, the data analysis system is used to analyze and detect the collected signals. The anesthesia system is used to keep the mice quiet and stable during the detection process.

[0003] Existing application number CN202120026594.9 The utility model discloses a small animal living bottom excitation detection device in the field of living body detection equipment, including an outer box, the inner wall of the outer box is fixedly connected with a radiation shielding box, the inner wall of the shielding box is fixedly connected with a heating stage, the upper surface of the heating stage is fixedly connected with a fixing mechanism, and the inner bottom wall of the shielding box is fixedly connected with an LED light source. In the utility model, a small animal can be placed on the heating stage, and the legs of the small animal can be tied by the binding part to prevent its legs from blocking the luminous imaging part without causing harm to the small animal, and the operation is convenient. The locking part can fix the length of the binding part after the small animal is tied up to avoid the winding part pulling the legs of the small animal, and the winding part can automatically wind up the binding part after the imaging is completed, so that the small animal living bottom excitation detection device solves the problem that the use of tape is time-consuming and may cause harm to the small animal.

[0004] Based on the above, the existing mouse living imaging detection device needs to place the anesthetized mouse with its abdomen facing up on the detection table, but the anesthetized mouse may experience unconscious shaking or convulsions under the influence of the type, dosage and administration method of the anesthetic drug. The shaking or convulsion of the mouse will cause the mouse detection position to change, affecting the experimental detection. Moreover, the imaging system mainly collects images from the abdomen and head of the mouse. The movement of the mouse's limbs to the abdomen will affect the experimental detection. In addition, the mouse's head needs to be placed inside the anesthesia tube of the anesthesia system. The shaking or convulsion of the mouse may cause the mouse's head to detach from the anesthesia tube, resulting in weak anesthesia effect of the mouse, causing the mouse to wake up and affect the experiment. Utility Model Content

[0005] In order to solve the above technical problems, the utility model provides a mouse live imaging detection device to solve the problem that the existing mouse live imaging detection device needs to place the anesthetized mouse with its abdomen facing upward on the detection table, but the anesthetized mouse may have unconscious shaking or convulsions under the influence of the type, dosage and administration method of the anesthetic drug. The shaking or convulsion of the mouse will cause the mouse detection position to change and affect the experimental detection. Moreover, the imaging system mainly collects images from the abdomen and head of the mouse. The movement of the mouse's limbs to the abdomen will affect the experimental detection. Moreover, the mouse's head needs to be placed inside the anesthesia tube of the anesthesia system. The shaking or convulsion of the mouse may cause the mouse's head to be separated from the anesthesia tube, resulting in weak anesthesia effect of the mouse, causing the mouse to wake up and affect the experiment.

[0006] The purpose and effect of the mouse in vivo imaging detection device of the utility model are achieved by the following specific technical means:

[0007] A mouse in vivo imaging detection device comprises an imaging detection body;

[0008] A sealed dark box door, which is hinged inside the imaging detection body;

[0009] An imaging camera, wherein the imaging camera is arranged inside the imaging detection body;

[0010] A lifting detection platform, which is fixedly installed inside the imaging detection body;

[0011] An anesthesia main body, the anesthesia main body is fixedly installed on the upper part of the lifting detection platform;

[0012] An anesthesia tube, the anesthesia tube being threadedly connected inside the anesthesia body;

[0013] A mouse fixing platform, the mouse fixing platform is placed above the lifting detection platform;

[0014] A limb fixing component, wherein the limb fixing component is arranged above the mouse fixing platform;

[0015] A head fixing component is arranged above the mouse fixing platform.

[0016] Furthermore, the limb fixing assembly includes:

[0017] A first convex chute, wherein the first convex chute is provided with two groups, and the two groups of first convex chute are opened inside the mouse fixing platform;

[0018] First sliding rods, wherein the first sliding rods are provided in four groups, and each two groups of first sliding rods are slidably connected inside a group of first convex sliding grooves;

[0019] Support plates, wherein two groups of support plates are provided, and the two groups of support plates are fixedly installed on the upper part of each two groups of first sliding rods.

[0020] Furthermore, the limb fixing assembly also includes:

[0021] A first threaded rod, the first threaded rod is rotatably connected to the inside of the first convex sliding groove, and the first threaded rod is connected to the inside of the two sets of first sliding rods through threads;

[0022] The first knob is fixedly mounted on one end of the first threaded rod and is threadably connected to the inside of the first sliding rod.

[0023] Furthermore, the limb fixing assembly also includes:

[0024] A driving rod, the driving rod being slidably connected inside the supporting plate;

[0025] A limit clamp is fixedly mounted on the end of the driving rod.

[0026] Furthermore, the limb fixing assembly also includes:

[0027] A guide rod, wherein the guide rod is slidably connected to the inside of the support plate and is fixedly mounted on the upper portion of the limit clamping plate;

[0028] A spring is fixedly mounted on the outside of the guide rod.

[0029] Furthermore, the head fixing assembly includes:

[0030] a second convex chute, wherein the second convex chute is disposed inside the mouse fixing platform;

[0031] a second threaded rod, the second threaded rod being rotatably connected inside the second convex sliding groove;

[0032] A second knob is fixedly mounted on one end of the second threaded rod.

[0033] Furthermore, the head fixing assembly includes:

[0034] A second sliding rod, wherein the second sliding rod is provided with two groups, the two groups of second sliding rods are slidably connected inside the second convex sliding groove, and the two groups of second sliding rods are connected inside the second threaded rod by threads;

[0035] The limiting clips are provided in two groups, and the two groups of limiting clips are respectively fixedly mounted on the upper parts of the two groups of second sliding rods.

[0036] Compared with the prior art, the utility model has the following beneficial effects:

[0037] First of all, the utility model has a limb fixing component, which drives the first threaded rod to rotate by turning the first knob, so that the support plate and the limiting splint move, so that the limiting splint can clamp mice of different sizes, which greatly improves the applicability of the device. In addition, the limbs of the mouse are fixed by the limiting splint, which effectively prevents the mouse from convulsing and causing the limbs to move to the abdomen position, affecting experimental detection.

[0038] Secondly, the utility model has a head fixing component, which drives the second threaded rod to rotate by turning the second knob, so that the two sets of limiting clips can fix the mouse's head, effectively preventing the mouse's head from detaching from the anesthesia tube, resulting in weak anesthesia effect of the mouse and causing the mouse to wake up and affect the experiment, thereby greatly improving the stability of the mouse's head.

[0039] The utility model has the advantages of being fixed and stable, preventing falling off, and being easy to operate. It can prevent mice from convulsing and causing their limbs to move to the abdomen to affect experimental detection, and can effectively prevent the head of the mouse from being separated from the anesthesia tube, resulting in weak anesthesia effect of the mouse and causing the mouse to wake up and affect the experiment. It greatly improves the stability of the mouse during the experiment, thereby making the experimental detection data more accurate. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] Figure 1 It is a schematic diagram of the main structure of the utility model.

[0041] Figure 2 It is a structural schematic diagram of the lifting and lowering testing platform of the utility model.

[0042] Figure 3 It is a structural schematic diagram of a mouse fixing platform of the utility model.

[0043] Figure 4 It is a schematic diagram of the first threaded rod structure of the utility model.

[0044] Figure 5 It is a schematic diagram of the second threaded rod structure of the utility model.

[0045] In the figure, the corresponding relationship between the component names and the figure numbers is as follows:

[0046] 1. Imaging detection body; 2. Sealed darkroom door; 3. Imaging camera; 4. Lifting detection platform; 5. Anesthesia body; 6. Anesthesia tube; 7. Mouse fixing platform; 701. First convex slide groove; 702. Second convex slide groove; 703. First sliding rod; 704. Support plate; 705. Limiting clamp; 706. Driving rod; 707. Guide rod; 708. Spring; 709. First knob; 710. First threaded rod; 711. Second knob; 712. Second threaded rod; 713. Second sliding rod; 714. Limiting clamp. DETAILED DESCRIPTION

[0047] The following is a further detailed description of the implementation of the present invention in conjunction with the accompanying drawings and examples. The following examples are used to illustrate the present invention, but cannot be used to limit the scope of the present invention.

[0048] Embodiment 1:

[0049] As attached Figure 1 To Attachment Figure 5 As shown:

[0050] The utility model provides a mouse living body imaging detection device, comprising an imaging detection body 1;

[0051] A sealed dark box door 2, which is hinged inside the imaging detection body 1;

[0052] An imaging camera 3, the imaging camera 3 is arranged inside the imaging detection body 1;

[0053] A lifting detection platform 4, which is fixedly installed inside the imaging detection body 1;

[0054] Anesthesia main body 5, anesthesia main body 5 is fixedly installed on the upper part of the lifting detection platform 4;

[0055] An anesthesia tube 6, which is threadedly connected to the inside of the anesthesia body 5;

[0056] A mouse fixing platform 7, which is placed above the lifting detection platform 4;

[0057] The limb fixing assembly is arranged above the mouse fixing platform 7.

[0058] Among them, the limb fixation components include:

[0059] A first convex chute 701, wherein two groups of the first convex chute 701 are provided, and the two groups of the first convex chute 701 are opened inside the mouse fixing platform 7;

[0060] First sliding rods 703, the first sliding rods 703 are provided in four groups, and every two groups of first sliding rods 703 are slidably connected inside a group of first convex sliding grooves 701;

[0061] The support plates 704 are provided with two groups, and the two groups of support plates 704 are fixedly mounted on the upper part of each two groups of first sliding rods 703; the function is to move the first sliding rod 703, and the first sliding rod 703 slides inside the first convex sliding groove 701, and the first convex sliding groove 701 plays a guiding and limiting role when the first sliding rod 703 slides, and the sliding of the first sliding rod 703 drives the support plates 704 to move.

[0062] Among them, the limb fixation components also include:

[0063] A first threaded rod 710, the first threaded rod 710 is rotatably connected to the inside of the first convex sliding groove 701, and the first threaded rod 710 is connected to the inside of the two sets of first sliding rods 703 through threads;

[0064] The first knob 709 is fixedly mounted on one end of the first threaded rod 710, and the first knob 709 is connected to the inside of the first sliding rod 703 through a thread; the function is that when the first knob 709 is turned, the first knob 709 drives the first threaded rod 710 to rotate inside the first convex groove 701, and the rotation of the first threaded rod 710 drives the two groups of first sliding rods 703 to slide relative to each other inside the first convex groove 701 through the thread.

[0065] Among them, the limb fixation components also include:

[0066] A driving rod 706, the driving rod 706 is slidably connected inside the supporting plate 704;

[0067] The limiting splint 705 is fixedly installed at the end of the driving rod 706; the role played is that the outer side of the limiting splint 705 is wrapped with cotton cloth, the cotton cloth reduces the pressure on the mouse, and the driving rod 706 is pulled, and the driving rod 706 drives the limiting splint 705 to move.

[0068] Among them, the limb fixation components also include:

[0069] A guide rod 707, the guide rod 707 is slidably connected to the inside of the support plate 704, and the guide rod 707 is fixedly mounted on the upper part of the limiting clamping plate 705;

[0070] Spring 708 , spring 708 is fixedly installed on the outside of guide rod 707 ; its function is that the limiting clamping plate 705 moves to compress spring 708 and drives guide rod 707 to slide inside support plate 704 .

[0071] The specific usage and function of this embodiment are as follows:

[0072] When it is necessary to fix the limbs of the mouse, the mouse is placed with its abdomen facing upward on the upper part of the mouse fixing platform 7, and the first knob 709 is turned. The first knob 709 drives the first threaded rod 710 to rotate inside the first convex slide groove 701. The first threaded rod 710 rotates and drives the first sliding rod 703 to slide inside the first convex slide groove 701 through the thread. The first convex slide groove 701 plays a guiding and limiting role when the first sliding rod 703 slides. The sliding of the first sliding rod 703 drives the support plate 704 to move, and the support plate 70 4 moves to the position of the mouse's limbs, pulls the driving rod 706, the driving rod 706 drives the limiting splint 705 to move, the limiting splint 705 moves to compress the spring 708 and drives the guide rod 707 to slide inside the support plate 704, the guide rod 707 plays a role of limiting guide when the limiting splint 705 moves, the mouse's limbs are placed at the bottom of the two groups of limiting splints 705 respectively, the driving rod 706 is released, the spring 708 drives the limiting splint 705 to move under the elastic force, and the limiting splint 705 fixes the mouse's limbs.

[0073] Embodiment 2:

[0074] Based on the first embodiment, Figures 1 to 5 As shown, it also includes:

[0075] A head fixing assembly is arranged above the mouse fixing platform 7 .

[0076] Wherein, the head fixing component includes:

[0077] A second convex chute 702, which is provided inside the mouse fixing platform 7;

[0078] A second threaded rod 712, the second threaded rod 712 is rotatably connected to the inside of the second convex sliding groove 702;

[0079] The second knob 711 is fixedly mounted on one end of the second threaded rod 712 . The second knob 711 drives the second threaded rod 712 to rotate inside the second convex sliding groove 702 by turning the second knob 711 .

[0080] Wherein, the head fixing component includes:

[0081] The second sliding rod 713 is provided with two groups, the two groups of second sliding rods 713 are slidably connected inside the second convex sliding groove 702, and the two groups of second sliding rods 713 are connected inside the second threaded rod 712 by threads;

[0082] The limiting clips 714 are provided with two groups, and the two groups of limiting clips 714 are respectively fixedly installed on the upper parts of the two groups of second sliding rods 713; the function is that the rotation of the second threaded rod 712 drives the two groups of second sliding rods 713 to move relative to each other, and the two groups of second sliding rods 713 drive the two groups of limiting clips 714 to move.

[0083] The specific usage and function of this embodiment are as follows:

[0084] When the mouse head needs to be clamped, the mouse head is placed in the middle position of the two groups of limiting clips 714, and the second knob 711 is turned. The second knob 711 drives the second threaded rod 712 to rotate inside the second convex slide groove 702. The rotation of the second threaded rod 712 drives the two groups of second sliding rods 713 to move relative to each other. The two groups of second sliding rods 713 drive the two groups of limiting clips 714 to move. The two groups of limiting clips 714 move to clamp the mouse head.

Claims

1. A mouse in vivo imaging detection device, characterized in that: The invention relates to a mouse live imaging detection device, comprising an imaging detection body (1); a sealed dark box door (2), the sealed dark box door (2) being hinged inside the imaging detection body (1); an imaging camera (3), the imaging camera (3) being arranged inside the imaging detection body (1); a lifting detection platform (4), the lifting detection platform (4) being fixedly mounted inside the imaging detection body (1); an anesthesia body (5), the anesthesia body (5) being fixedly mounted on the upper part of the lifting detection platform (4); an anesthesia tube (6), the anesthesia tube (6) being threadedly connected inside the anesthesia body (5); a mouse fixing platform (7), the mouse fixing platform (7) being placed above the lifting detection platform (4); a limb fixing component, the limb fixing component being arranged above the mouse fixing platform (7); and a head fixing component, the head fixing component being arranged above the mouse fixing platform (7).

2. A mouse in vivo imaging detection device as claimed in claim 1, characterized in that: The limb fixing assembly comprises: a first convex chute (701), a first sliding rod (703) and a support plate (704); the first convex chute (701) is provided with two groups, and the two groups of first convex chute (701) are opened inside the mouse fixing platform (7); the first sliding rod (703) is provided with four groups, and every two groups of first sliding rods (703) are slidably connected inside a group of first convex chute (701); Two groups of support plates (704) are provided, and the two groups of support plates (704) are fixedly mounted on the upper parts of each two groups of first sliding rods (703).

3. A mouse in vivo imaging detection device as claimed in claim 2, characterized in that: The limb fixing assembly further comprises: a first threaded rod (710) and a first knob (709); the first threaded rod (710) is rotatably connected to the inside of the first convex sliding groove (701); the first threaded rod (710) is threadably connected to the inside of the two sets of first sliding rods (703); and the first knob (709) is fixedly mounted on one end of the first threaded rod (710); the first knob (709) is threadably connected to the inside of the first sliding rod (703).

4. A mouse in vivo imaging detection device as claimed in claim 2, characterized in that: The limb fixing assembly further comprises: a driving rod (706) and a limiting clamp plate (705); the driving rod (706) is slidably connected inside the support plate (704); and the limiting clamp plate (705) is fixedly mounted on the end of the driving rod (706).

5. A mouse in vivo imaging detection device as claimed in claim 2, characterized in that: The limb fixing assembly further comprises: a guide rod (707) and a spring (708); the guide rod (707) is slidably connected to the inside of the support plate (704); the guide rod (707) is fixedly mounted on the upper part of the limiting clamp (705); and the spring (708) is fixedly mounted on the outside of the guide rod (707).

6. A mouse in vivo imaging detection device as claimed in claim 1, characterized in that: The head fixing assembly comprises: a second convex chute (702), a second threaded rod (712) and a second knob (711); the second convex chute (702) is arranged inside the mouse fixing platform (7); the second threaded rod (712) is rotatably connected inside the second convex chute (702); and the second knob (711) is fixedly mounted on one end of the second threaded rod (712).

7. A mouse in vivo imaging detection device as claimed in claim 6, characterized in that: The head fixing assembly comprises: a second sliding rod (713) and a limiting clip (714); the second sliding rod (713) is provided in two groups, and the two groups of second sliding rods (713) are slidably connected inside the second convex sliding groove (702); and the limiting clip (714) is provided in two groups, and the two groups of limiting clips (714) are respectively fixedly installed on the upper parts of the two groups of second sliding rods (713).

Images