Exposure contamination cabin
By designing an exposure poisoning chamber including a cabin, a roof, a fixed structure and a respiratory mask, the existing inhalation exposure poisoning system has solved the problems of high equipment costs, large space requirements and animal poisoning interference, and achieved a closed exposure poisoning test, reducing costs and space requirements, and improving experimental safety and accuracy.
Patent Information
- Application Number
- CN202420687239.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-04-03
- Publication Date
- 2025-02-28
- Estimated Expiration
- 2034-04-03
AI Technical Summary
The existing inhalation exposure and poisoning system has problems in the experiment that high equipment operation costs, large experimental space requirements, and exposure to the whole body of animals may lead to poisoning of the skin and hair and interfere with the experimental results.
An exposure and poison pollution cabin was designed, including the cabin, the top cover, the fixed structure, the respiratory mask and the duct system. The test body is fixed through the fixed structure, the respiratory mask and the duct system can achieve the sealed exposure and pollution of the animal's respiratory system to avoid aerosol leakage.
Exposure and poisoning tests are implemented in confined spaces, reducing equipment operating costs and experimental space requirements, avoiding aerosol leakage and animal skin hair dyeing, and improving the safety and accuracy of the experiment.
Smart Images

Figure CN222533433U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of poisoning experiments, in particular to an exposure poisoning cabin. Background Art
[0002] Equipment that exposes the respiratory system to toxicity by inhaling the test substance through the respiratory tract is collectively referred to as an inhalation exposure system. According to the degree of exposure of the animal to the test substance, it is divided into an oral and nasal inhalation exposure system and a whole-body inhalation exposure system. During the animal exposure room experiment, the former only exposes the mouth and nose to the test substance environment, thereby only toxicating the respiratory system; the latter will expose the whole body of the small animal to the test substance environment to complete the respiratory system toxicity.
[0003] The animals in the whole body inhalation exposure system are exposed to the test substance environment, so generally in a larger poisoning chamber, the animals can move freely, the real poisoning environment can be simulated, and the behavioral effects of animal toxicology can be recorded. However, due to the large poisoning chamber, the system occupies a lot of space and the amount of test substance required is also large, and the operating cost of the equipment and the experimental reagents are high. In addition, if the test substance has the characteristics of being toxic by inhalation through the animal skin or hair, it will interfere with the experimental results.
[0004] The oral and nasal inhalation exposure system restricts the animal's activities through an animal holder, directly connects the animal's mouth and nose to the aerosol pipe of the test substance, and exposes the animal's respiratory system only through the mouth and nose. In this way, the consumption of the test substance is greatly reduced and the possibility of animal skin and hair contamination is avoided, while the requirements for experimental space are also reduced. According to the different experimental animals, it can be divided into small animal oral and nasal exposure system and large animal oral and nasal exposure system, among which beagles are the representatives of large animals. However, when animals are given drugs through the mouth and nose, drug aerosols are easy to leak into the laboratory, which may cause damage to the health of the experimenters and do not meet the requirements of occupational health. Utility Model Content
[0005] In view of the defects in the prior art, the purpose of the utility model is to provide an exposure and contamination cabin.
[0006] According to the utility model, an exposure and contamination cabin is provided, comprising: a cabin body and a top cover, wherein the top cover is arranged on the cabin body;
[0007] A fixing structure is provided in the cabin, and the fixing structure includes a fixing belt and an adjustment structure; the fixing belt is connected to the cabin through the adjustment structure, and the size of the fixing belt can be adjusted through the adjustment structure; the fixing belt is used to fix the test object in the cabin;
[0008] A breathing mask is arranged in the cabin, and the breathing mask is used to cover the mouth and nose of the test subject; an air inlet and an air outlet are arranged on the cabin, and the air inlet is used for an air intake pipe to pass through and connect to the mouth and nose mask, and the air outlet is used to connect to the outlet pipe.
[0009] Preferably, the adjustment structure comprises a first adjustment rod and a second adjustment rod;
[0010] The first adjusting rod and the second adjusting rod are slidably arranged on the cabin body, and the first adjusting rod and the second adjusting rod can move closer to or farther from each other by sliding;
[0011] Two ends of the fixing belt are respectively connected to the first adjusting rod and the second adjusting rod.
[0012] Preferably, the cabin is provided with a first adjustment slide groove and a second adjustment slide groove;
[0013] The first adjusting rod is slidably disposed on the cabin body through the first adjusting sliding groove, and the second adjusting rod is slidably disposed on the cabin body through the second adjusting sliding groove.
[0014] Preferably, a side door is provided on the cabin body in an area corresponding to the legs of the test subject;
[0015] The side door can be opened / closed on the cabin body, and when the side door is closed, the side door is sealed and connected to the cabin body.
[0016] Preferably, a front door is provided on the cabin in an area corresponding to the head of the test subject;
[0017] The front door can be opened / closed on the cabin body, and when the front door is closed, the front door is sealed and connected to the cabin body;
[0018] The air inlet and the air outlet are arranged on the front door.
[0019] Preferably, a handle is rotatably provided on the top cover, and an elastic buckle block is provided on the cabin body;
[0020] When the top cover is closed, the handle can be buckled on the elastic buckle block.
[0021] Preferably, a gas spring is connected between the top cover and the cabin body.
[0022] Preferably, a micro pressure gauge is provided on the cabin, and the micro pressure gauge is used to detect the pressure in the cabin.
[0023] Preferably, a three-way valve is provided at the bottom of the cabin.
[0024] Preferably, movable wheels are provided at the bottom of the cabin.
[0025] Compared with the prior art, the utility model has the following beneficial effects:
[0026] 1. The utility model forms a closed space through the cabin and the top cover, places the test animal in the cabin, fixes the test animal through a fixing structure, and connects the breathing mask on the head of the test animal through a pipeline, thereby realizing the exposure and poisoning test in the closed space and avoiding the problem of aerosol leakage.
[0027] 2. The fixing belt of the utility model can be adjusted in size by adjusting the structure, and can be suitable for test animals of different sizes, which greatly improves the practicality.
[0028] 3. The utility model is provided with side doors and front doors on the cabin body, so as to facilitate fixing the legs and head of the test animals, facilitate wearing of the breathing mask, and improve the convenience of use.
[0029] 4. The utility model provides a three-way valve at the bottom of the cabin, which can be used for vacuuming during the experiment to prevent the medicine in the cabin from escaping to the outside and affecting the health of the experimenters. After the experiment is completed, the drain port can be switched to clean and disinfect the cabin. A floor drain is installed on the top of the three-way valve to prevent blockage caused by animal excrement, hair, etc. BRIEF DESCRIPTION OF THE DRAWINGS
[0030] Other features, objects and advantages of the present invention will become more apparent by reading the detailed description of non-limiting embodiments with reference to the following drawings:
[0031] Figure 1 This is a schematic diagram of the overall structure of the exposed contaminated cabin;
[0032] Figure 2 It is a schematic diagram of the three-dimensional structure of the top cover, side door and front door of the exposed contaminated cabin when they are opened;
[0033] Figure 3 The main view of the top cover, side door and front door of the exposed contaminated cabin when opened;
[0034] Figure 4 A top view of the exposed contaminated cabin with its top cover, side door and front door opened;
[0035] Figure 5 To highlight the schematic diagram of the buckle structure;
[0036] Figure 6 A structural diagram to highlight the installation position of the arm sleeve;
[0037] Figure 7 To highlight the schematic diagram of the structure of the three-way valve;
[0038] Figure 8 A schematic diagram showing the structure of the floor drain is shown.
[0039] The figure shows:
[0040] Cabin 1 Side door 5
[0041] Air Inlet 101 Front Door 6
[0042] Air outlet 102 Handle 7
[0043] First adjustment slide groove 103 Elastic buckle block 8
[0044] Second adjustment slide 104 gas spring 9
[0045] Top cover 2 Micro pressure gauge 10
[0046] First operating arm set 201 three-way valve 11
[0047] Second operating arm sleeve 202 Air extraction port 1101
[0048] Observation window 203 Drain port 1102
[0049] Fixed structure 3 Moving wheels 12
[0050] Fixing belt 301 Sealing strip 13
[0051] Adjustment structure 302 Test body 14
[0052] First adjustment rod 3021 Rotary door lock 15
[0053] Second adjustment rod 3022 buckle 16
[0054] Respiratory mask 4 Floor drain 17 DETAILED DESCRIPTION
[0055] The utility model is described in detail below in conjunction with specific embodiments. The following embodiments will help those skilled in the art to further understand the utility model, but do not limit the utility model in any form. It should be pointed out that for those of ordinary skill in the art, several changes and improvements can be made without departing from the concept of the utility model. These all belong to the protection scope of the utility model.
[0056] Example:
[0057] like Figures 1 to 8As shown, this embodiment provides an exposure and contamination cabin, including: a cabin body 1 and a top cover 2, the top cover 2 is arranged on the cabin body 1; a fixing structure 3 is arranged in the cabin body 1, and the fixing structure 3 includes a fixing belt 301 and an adjustment structure 302; the fixing belt 301 is connected and arranged on the cabin body 1 through the adjustment structure 302, and the fixing belt 301 can be adjusted in size through the adjustment structure 302; the fixing belt 301 is used to fix the test body 14 in the cabin body 1; a breathing mask 4 is arranged in the cabin body 1, and the breathing mask 4 is used to cover the mouth and nose of the test body 14; an air inlet 101 and an air outlet 102 are arranged on the cabin body 1, the air inlet 103 is used for the air inlet pipe to pass through and connect the mouth and nose mask, and the air outlet 104 is used to connect the air outlet pipe. The top cover 2 can be opened / closed on the cabin body 1, and when the top cover 2 is closed, the top cover 2 and the cabin body 1 are sealed and connected.
[0058] A side door 5 is provided on the cabin 1 in an area corresponding to the legs of the test object; the side door 5 can be opened / closed on the cabin 1, and when the side door 5 is closed, the side door 5 is sealed and connected to the cabin 1. A front door 6 is provided on the cabin 1 in an area corresponding to the head of the test object; the front door 6 can be opened / closed on the cabin 1, and when the front door 6 is closed, the front door 6 is sealed and connected to the cabin 1; an air inlet 101 and an air outlet 102 are provided on the front door 6. A micro pressure gauge 10 is provided on the cabin 1, and the micro pressure gauge 10 is used to detect the pressure in the cabin 1.
[0059] The adjustment structure 302 includes a first adjustment rod 3021 and a second adjustment rod 3022; the first adjustment rod 3021 and the second adjustment rod 3022 are slidably arranged on the cabin 1, and the first adjustment rod 3021 and the second adjustment rod 3022 can move closer to each other or farther away from each other by sliding; the two ends of the fixing belt 301 are respectively connected to the first adjustment rod 3021 and the second adjustment rod 3022. The cabin 1 is provided with a first adjustment slot 103 and a second adjustment slot 104; the first adjustment rod 3021 is slidably arranged on the cabin 1 through the first adjustment slot 103, and the second adjustment rod 3022 is slidably arranged on the cabin 1 through the second adjustment slot 104.
[0060] A handle 7 is rotatably provided on the top cover 2, and an elastic buckle block 8 is provided on the cabin body 1; when the top cover 2 is closed, the handle 7 can be buckled on the elastic buckle block 8. A gas spring 9 is connected between the top cover 2 and the cabin body 1. A three-way valve 11 is provided at the bottom of the cabin body 1. A moving wheel 12 is provided at the bottom of the cabin body 1.
[0061] The top cover 2 is provided with a first operating arm cover 201, a second operating arm cover 202 and an observation window 203; the first operating arm cover 201 and the second operating arm cover 202 can contact the test body in the cabin 1. The opening ends of the first operating arm cover 201 and the second operating arm cover 202 are sealed and connected to the top cover 2. The first operating arm cover 201 and the second operating arm cover 202 are detachably arranged on the top cover 2. The observation window 203 is a transparent glass observation window, and the first operating arm cover 201 and the second operating arm cover 202 are arranged on the observation window 203. A mounting hole is opened on the observation window 203, and the first operating arm cover 201 and the second operating arm cover 202 are sealed and threadedly connected to the mounting hole.
[0062] In this embodiment, the entire exposure and contamination cabin is made of 304 stainless steel, and the top cover 2, the side door 5 and the front door 6 are all fixed by hinges and are all equipped with sealing strips 13 to ensure that the cabin is sealed.
[0063] The top cover 2 is directly locked by a handle 7 and an elastic buckle block 8, which is convenient for opening the top cover 2 and simplifies the door opening procedure. Gas springs 9 are installed on both sides of the top cover 2 to make door opening easier, and a micro pressure gauge 10 in front of the top cover 2 can detect the pressure in the cabin in real time to avoid danger to animals.
[0064] The side door 5 adopts a rotary door lock 15, and the side door 5 can be opened by simply rotating the door lock. The side door 5 is located at the animal's legs, which is convenient for fixing the animal's limbs.
[0065] The adjusting structure 302 is used in the cabin 1 to provide adjustably support for the fixing belt 301 , and the distance between the first adjusting rod 3021 and the second adjusting rod 3022 can be adjusted according to the size of the experimental animal.
[0066] The front door 6 is locked with a buckle 16 for easy opening. If the animal suffocates during the experiment, it can be quickly opened. Interfaces for installing the first operating arm cover 201 and the second operating arm cover 202 are reserved on both sides of the top observation window 203, which can be used to comfort the experimental animal when it is irritable.
[0067] A three-way ball valve is installed at the bottom of the cabin 1. During the experiment, air can be pumped out through the air pumping port 1101 to prevent the medicine in the cabin 1 from being released outside the cabin 1 and affecting the health of the experimenters. After the experiment is completed, the drain port 1102 can be switched to clean and disinfect the cabin 1. A floor drain 17 is installed on the top of the three-way valve 11 to prevent blockage caused by animal excrement, hair, etc.
[0068] On the basis of providing a closed cabin, this embodiment sets an operating arm sleeve and an observation window on the top cover, observes the test animals in the cabin through the observation window, and fixes the test animals through the operating arm sleeve. At the same time, when the test animals are agitated, they can also be soothed by the operating arm sleeve. In addition, a breathing mask is also provided to avoid the problem of leakage or direct disconnection of the connection between the aerosol pipe and the mouth and nose of the test animals to varying degrees. The operating arm sleeve of this embodiment is detachably set on the top cover. When the operating arm sleeve is damaged and needs to be replaced, it can be directly replaced, or replaced with an operating arm sleeve of different materials according to different contamination reagents, so as to achieve a better isolation effect of the operating arm sleeve, thereby greatly improving practicality.
[0069] The exposure and poisoning chamber of the utility model can be suitable for large animal test bodies, can avoid the leakage of drug aerosols, and improve safety.
[0070] In the description of the present application, it should be understood that the terms "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.
[0071] The above describes the specific embodiments of the present invention. It should be understood that the present invention is not limited to the above specific embodiments, and those skilled in the art can make various changes or modifications within the scope of the claims, which does not affect the essence of the present invention. In the absence of conflict, the embodiments of the present application and the features in the embodiments can be combined with each other at will.
Claims
1. An exposure and contamination cabin, characterized in that: include: A cabin body (1) and a top cover (2), wherein the top cover (2) is arranged on the cabin body (1); The cabin (1) is provided with a fixing structure (3), the fixing structure (3) comprising a fixing belt (301) and an adjustment structure (302); the fixing belt (301) is connected to the cabin (1) via the adjustment structure (302), and the size of the fixing belt (301) can be adjusted via the adjustment structure (302); the fixing belt (301) is used to fix the test object in the cabin (1); A breathing mask (4) is arranged in the cabin (1), and the breathing mask (4) is used to cover the mouth and nose of the test subject; an air inlet (101) and an air outlet (102) are arranged on the cabin (1), and the air inlet (101) is used for an air inlet pipe to pass through and connect to the mouth and nose mask, and the air outlet (102) is used to connect to an air outlet pipe.
2. The exposure and contamination chamber according to claim 1, characterized in that: The adjustment structure (302) comprises a first adjustment rod (3021) and a second adjustment rod (3022); The first adjustment rod (3021) and the second adjustment rod (3022) are slidably arranged on the cabin (1), and the first adjustment rod (3021) and the second adjustment rod (3022) can move closer to or farther from each other by sliding; The two ends of the fixing belt (301) are respectively connected to the first adjustment rod (3021) and the second adjustment rod (3022).
3. The exposure and contamination chamber according to claim 2, characterized in that: The cabin (1) is provided with a first adjustment slide groove (103) and a second adjustment slide groove (104); The first adjustment rod (3021) is slidably arranged on the cabin body (1) through the first adjustment sliding groove (103), and the second adjustment rod (3022) is slidably arranged on the cabin body (1) through the second adjustment sliding groove (104).
4. The exposure and contamination chamber according to claim 1, characterized in that: A side door (5) is provided on the cabin (1) in an area corresponding to the legs of the test subject; The side door (5) can be opened / closed on the cabin body (1); when the side door (5) is closed, the side door (5) and the cabin body (1) are sealed and connected.
5. The exposure and contamination chamber according to claim 1, characterized in that: A front door (6) is provided on the cabin (1) in an area corresponding to the head of the test subject; The front door (6) can be opened / closed on the cabin (1); when the front door (6) is closed, the front door (6) and the cabin (1) are sealed; The air inlet (101) and the air outlet (102) are arranged on the front door (6).
6. The exposure chamber according to claim 1, characterized in that: The top cover (2) is rotatably provided with a handle (7), and the cabin body (1) is provided with an elastic buckle block (8); When the top cover (2) is closed, the handle (7) can be buckled onto the elastic buckle block (8).
7. The exposure chamber according to claim 1, characterized in that: A gas spring (9) is connected between the top cover (2) and the cabin body (1).
8. The exposure chamber according to claim 1, characterized in that: The cabin (1) is provided with a micro pressure gauge (10), and the micro pressure gauge (10) is used to detect the pressure inside the cabin (1).
9. The exposure chamber according to claim 1, characterized in that: A three-way valve (11) is provided at the bottom of the cabin (1).
10. The exposure chamber according to claim 1, characterized in that: The bottom of the cabin (1) is provided with moving wheels (12).